FB2020_02, released Apr 14, 2020

Gene: Dmel\garz

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General Information
Symbol
Dmel\garz
Species
D. melanogaster
Name
gartenzwerg
Annotation Symbol
CG8487
Feature Type
protein_coding_gene
FlyBase ID
FBgn0264560
Gene Model Status
Current
Stock Availability
9 publicly available
Gene Snapshot
gartenzwerg (garz) encodes a guanine nucleotide exchange factor localized to the cis-Golgi apparatus. The roles of the product of garz include membrane and protein trafficking between the Golgi apparatus and the endoplasmic reticulum. It is required for epithelial morphogenesis in the embryo. [Date last reviewed: 2019-03-07]
Other Summaries
Also Known As

ang, CG 8487, sec7-family GEF

Key Links
Genomic Location
Cytogenetic map
48F8-48F10
Sequence location
2R:12,326,360..12,333,860 [+]
Recombination map

2-66

RefSeq locus
NT_033778 REGION:12326360..12333860
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Molecular Function (GO)
[Detailed GO annotations]
Experimental Evidence
ARF guanyl-nucleotide exchange factor activity; Rab GTPase binding
Predictions / Assertions
-
Summaries
Gene Group (FlyBase)
ARF GUANINE NUCLEOTIDE EXCHANGE FACTORS -
ArfGEFs are Guanine Nucleotide Exchange Factors (GEFs) for ARF family GTPases. They are characterized by a central Sec7 catalytic domain domain with homology to yeast SEC7. (Adapted from PMID:15731001, FBrf0158741 and FBrf0220529).
Phenotypic Description (Red Book; Lindsley and Zimm 1992)
ang: angle wing
Wings held up from dorsal surfaces and extended outward 15-90 from the mid-dorsal line. Longitudinal dorsal median muscles 5 and 6 fused (Goldberg, 1954, Ph.D. Thesis, Ill. Inst. Technol.). No increase in expressivity with temperature. Does not overlap wild type. RK2.
Gene Model and Products
Number of Transcripts
3
Number of Unique Polypeptides
3

Please see the GBrowse view of Dmel\garz or the JBrowse view of Dmel\garz for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Gene model reviewed during 5.49

Sequence Ontology: Class of Gene
gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
garz-RA
FBtr0087898
NM_165881
5631
1740
garz-RB
FBtr0087897
NM_136917
6630
1983
garz-RC
FBtr0305075
NM_001259349
5634
1741
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
garz-PA
FBpp0087011
194.9
1740
5.66
NP_725133
AAM68666
garz-PB
FBpp0087010
220.6
1983
5.08
NP_610761
AAF58532
garz-PC
FBpp0293612
194.9
1741
5.66
NP_001246278
AFH08032
Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\garz using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Gene Ontology (14 terms)
Molecular Function (2 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
ARF guanyl-nucleotide exchange factor activity
inferred from genetic interaction with FLYBASE:Arf79F; FB:FBgn0010348, FLYBASE:ArfGAP1; FB:FBgn0020655
(Armbruster and Luschnig, 2012)
Rab GTPase binding
inferred from physical interaction with UniProtKB:O18332
(Sechi et al., 2017)
Terms Based on Predictions or Assertions (0 terms)
Biological Process (10 terms)
Terms Based on Experimental Evidence (9 terms)
CV Term
Evidence
References
cell morphogenesis
inferred from mutant phenotype
(D'Ambrosio and Vale, 2010)
epithelial cell development
inferred from direct assay
(Szul et al., 2011)
Golgi organization
inferred from mutant phenotype
(Armbruster and Luschnig, 2012)
lumen formation, open tracheal system
inferred from direct assay
(Wang et al., 2012)
protein secretion
inferred from mutant phenotype
(Armbruster and Luschnig, 2012)
regulation of GTPase activity
inferred from genetic interaction with FLYBASE:Arf79F; FB:FBgn0010348
(Armbruster and Luschnig, 2012)
regulation of tube diameter, open tracheal system
inferred from mutant phenotype
(Armbruster and Luschnig, 2012)
salivary gland development
inferred from direct assay
(Szul et al., 2011)
secretion by cell
inferred from direct assay
(Wang et al., 2012)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
regulation of ARF protein signal transduction
inferred from electronic annotation with InterPro:IPR000904
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
inferred by curator from GO:0005086
(FlyBase Curators, 2008--)
Cellular Component (2 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
cis-Golgi network
inferred from direct assay
(Wang et al., 2012)
Golgi cis cisterna
inferred from direct assay
(Armbruster and Luschnig, 2012)
Terms Based on Predictions or Assertions (0 terms)
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
cis-Golgi network
inferred from direct assay
(Wang et al., 2012)
Golgi cis cisterna
inferred from direct assay
(Armbruster and Luschnig, 2012)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\garz in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 15 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 10 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of garz
Transgenic constructs containing regulatory region of garz
Deletions and Duplications ( 7 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal, with Scer\GAL4Mef2.PR
lethal, with Scer\GAL4pnr-MD237
lethal (with garzEMS667)
lethal (with garzEP2028)
lethal (with garzS4-50)
lethal | pupal stage, with Scer\GAL4pnr-MD237
lethal - all die before end of first instar larval stage
lethal - all die before end of first instar larval stage (with Df(2R)Exel6061)
partially lethal, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4tin.CΔ4
Other Phenotypes
Allele
developmental rate defective
developmental rate defective (with Df(2R)Exel6061)
developmental rate defective | embryonic stage (with Df(2R)Exel6061)
endocytosis defective | third instar larval stage, with Scer\GAL4Hml.Δ
endocytosis defective | third instar larval stage, with Scer\GAL4srp.PU
exocytosis defective | third instar larval stage, with Scer\GAL4SPARC-MI00329-GAL4
neuroanatomy defective | larval stage, with Scer\GAL4elav-C155
neuroanatomy defective | third instar larval stage, with Scer\GAL4elav-C155
neuroanatomy defective | third instar larval stage, with Scer\GAL4RapGAP1-OK6
pain response defective | adult stage, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
some die during first instar larval stage
some die during first instar larval stage (with Df(2R)Exel6061)
visible, with Scer\GAL4GMR.PF
visible | recessive
Phenotype manifest in
Allele
anterior fascicle & synapse, with Scer\GAL4elav-C155
anterior fascicle & synapse | supernumerary, with Scer\GAL4elav-C155
cis-Golgi network | embryonic stage
cortical zone of lymph gland primary lobe | third instar larval stage, with Scer\GAL4Hml.Δ
crystal cell | third instar larval stage, with Scer\GAL4Hml.Δ
dorsal medial indirect flight muscle
embryonic/first instar larval cuticle
embryonic/larval cuticle (with Df(2R)Exel6061)
embryonic/larval fat body | third instar larval stage, with Scer\GAL4SPARC-MI00329-GAL4
embryonic/larval neuromuscular junction | third instar larval stage, with Scer\GAL4elav-C155
embryonic/larval neuromuscular junction | third instar larval stage, with Scer\GAL4RapGAP1-OK6
embryonic/larval salivary gland, with Scer\GAL4fkh.PH
embryonic/larval salivary gland (with Df(2R)Exel6061)
embryonic/larval trachea
extracellular matrix | third instar larval stage, with Scer\GAL4SPARC-MI00329-GAL4
eye, with Scer\GAL4GMR.PF
eye photoreceptor cell, with Scer\GAL4GMR.PF
hemocyte | third instar larval stage, with Scer\GAL4srp.PU
intersegmental nerve, with Scer\GAL4elav-C155
NMJ bouton | third instar larval stage, with Scer\GAL4elav-C155
NMJ bouton | third instar larval stage, with Scer\GAL4RapGAP1-OK6
ommatidium | adult stage, with Scer\GAL4ninaE.PU
ommatidium | adult stage | progressive | conditional, with Scer\GAL4ninaE.PU
plasmatocyte | third instar larval stage, with Scer\GAL4Hml.Δ
posterior signalling center of lymph gland primary lobe | third instar larval stage, with Scer\GAL4Hml.Δ
retina | adult stage | progressive | conditional, with Scer\GAL4ninaE.PU
rhabdomere, with Scer\GAL4GMR.PF
rough endoplasmic reticulum | embryonic stage
salivary gland | embryonic stage
secondary lobe of embryonic/larval lymph gland | third instar larval stage, with Scer\GAL4Hml.Δ
tracheal lumen
tracheal lumen, with Scer\GAL4btl.PS
tracheal lumen (with Df(2R)Exel6061)
tracheal lumen | embryonic stage
vesicle | embryonic stage
wing
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v7.1)
Homo sapiens (Human) (16)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\GBF1
15 of 15
Yes
Yes
 
 
Hsap\ARFGEF1
3 of 15
No
No
Hsap\ARFGEF2
3 of 15
No
No
Hsap\CYTH2
2 of 15
No
No
Hsap\CYTH3
2 of 15
No
No
Hsap\FBXO8
2 of 15
No
Yes
Hsap\IQSEC1
2 of 15
No
No
 
Hsap\IQSEC2
2 of 15
No
No
Hsap\IQSEC3
2 of 15
No
No
Hsap\PSD2
2 of 15
No
No
Hsap\PSD3
2 of 15
No
No
Hsap\PSD4
2 of 15
No
No
 
Hsap\CYTH1
1 of 15
No
No
 
Hsap\CYTH4
1 of 15
No
No
Hsap\MON2
1 of 15
No
No
Hsap\PSD
1 of 15
No
No
Model Organism Orthologs (via DIOPT v7.1)
Mus musculus (laboratory mouse) (16)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Gbf1
15 of 15
Yes
Yes
Mmus\Arfgef2
3 of 15
No
No
Mmus\Arfgef1
2 of 15
No
No
Mmus\Cyth2
2 of 15
No
No
Mmus\Cyth3
2 of 15
No
No
Mmus\Fbxo8
2 of 15
No
Yes
Mmus\Iqsec2
2 of 15
No
No
Mmus\Iqsec3
2 of 15
No
No
Mmus\Psd2
2 of 15
No
No
Mmus\Psd3
2 of 15
No
No
Mmus\Psd4
2 of 15
No
No
Mmus\Cyth1
1 of 15
No
No
Mmus\Cyth4
1 of 15
No
No
Mmus\Iqsec1
1 of 15
No
No
Mmus\Mon2
1 of 15
No
No
Mmus\Psd
1 of 15
No
No
Rattus norvegicus (Norway rat) (15)
Rnor\Gbf1
13 of 13
Yes
Yes
Rnor\Arfgef1
3 of 13
No
No
Rnor\Arfgef2
3 of 13
No
No
Rnor\Cyth2
2 of 13
No
No
Rnor\Cyth3
2 of 13
No
No
Rnor\Fbxo8
2 of 13
No
Yes
Rnor\Iqsec3
2 of 13
No
No
Rnor\Psd2
2 of 13
No
No
Rnor\Psd4
2 of 13
No
No
Rnor\Cyth1
1 of 13
No
No
Rnor\Cyth4
1 of 13
No
No
Rnor\Iqsec1
1 of 13
No
No
Rnor\Iqsec2
1 of 13
No
No
Rnor\Psd3
1 of 13
No
No
Rnor\Psd
1 of 13
No
No
Xenopus tropicalis (Western clawed frog) (14)
Xtro\gbf1
9 of 12
Yes
Yes
Xtro\arfgef2
3 of 12
No
No
Xtro\cyth1
2 of 12
No
No
Xtro\cyth3
2 of 12
No
No
Xtro\fbxo8
2 of 12
No
Yes
Xtro\iqsec1
2 of 12
No
No
Xtro\iqsec2
2 of 12
No
No
Xtro\iqsec3
2 of 12
No
No
Xtro\psd3
2 of 12
No
No
Xtro\arfgef1
1 of 12
No
No
Xtro\cyth2
1 of 12
No
No
Xtro\cyth4
1 of 12
No
No
Xtro\mon2
1 of 12
No
No
Xtro\psd4
1 of 12
No
No
Danio rerio (Zebrafish) (21)
Drer\gbf1
12 of 15
Yes
Yes
Drer\arfgef1
3 of 15
No
No
Drer\arfgef2
3 of 15
No
No
Drer\cyth3a
2 of 15
No
No
Drer\cyth3b
2 of 15
No
No
Drer\cyth4a
2 of 15
No
No
Drer\cyth4b
2 of 15
No
No
Drer\iqsec1a
2 of 15
No
No
Drer\iqsec1b
2 of 15
No
No
Drer\iqsec2b
2 of 15
No
No
Drer\iqsec3a
2 of 15
No
No
Drer\iqsec3b
2 of 15
No
No
Drer\psd2
2 of 15
No
No
Drer\psd3l
2 of 15
No
No
Drer\si:dkey-283b15.4
2 of 15
No
No
Drer\cyth1b
1 of 15
No
No
Drer\fbxo8
1 of 15
No
Yes
Drer\LOC560461
1 of 15
No
No
Drer\LOC101886286
1 of 15
No
No
Drer\mon2
1 of 15
No
No
Drer\psda
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (5)
Cele\gbf-1
12 of 15
Yes
Yes
Cele\agef-1
2 of 15
No
No
Cele\bris-1
1 of 15
No
No
Cele\efa-6
1 of 15
No
No
Cele\grp-1
1 of 15
No
No
Arabidopsis thaliana (thale-cress) (8)
Atha\GN
9 of 9
Yes
Yes
Atha\GNL1
8 of 9
No
Yes
Atha\GNL2
7 of 9
No
Yes
Atha\AT3G60860
1 of 9
No
No
Atha\AT4G35380
1 of 9
No
No
Atha\AT4G38200
1 of 9
No
No
Atha\ATMIN7
1 of 9
No
No
Atha\EDA10
1 of 9
No
No
Saccharomyces cerevisiae (Brewer's yeast) (5)
Scer\GEA1
11 of 15
Yes
Yes
Scer\GEA2
10 of 15
No
Yes
Scer\SEC7
2 of 15
No
No
Scer\SYT1
1 of 15
No
No
Scer\YEL1
1 of 15
No
No
Schizosaccharomyces pombe (Fission yeast) (1)
Spom\SPBC211.03c
8 of 12
Yes
Yes
Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG091900H9 )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00002603
Drosophila simulans
Dsim\GD10856
Drosophila sechellia
Dsec\GM21360
Drosophila erecta
Dere\GG20274
Drosophila yakuba
Dyak\GE12432
Drosophila ananassae
Dana\GF12843
Drosophila pseudoobscura pseudoobscura
Dpse\GA21111
Drosophila persimilis
Dper\GL10823
Drosophila willistoni
Dwil\GK22165
Drosophila virilis
Dvir\GJ19764
Drosophila mojavensis
Dmoj\GI18338
Drosophila grimshawi
Dgri\GH23159
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091500BU )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17021238
Glossina morsitans
Tsetse fly
Gmor\GMOY010070
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_07365
Mayetiola destructor
Hessian fly
Mdes\Mdes007591
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL009678
Anopheles darlingi
American malaria mosquito
Adar\ADAC006031
Anopheles gambiae
Malaria mosquito
Agam\AGAP001527
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ001197
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W014W )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA007381
Bombyx mori
Silkmoth
Bmor\BGIBMGA007380
Danaus plexippus
Monarch butterfly
Dple\DPOGS205316-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS205315-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL016008
Apis florea
Little honeybee
Aflo\2370960068
Apis mellifera
Western honey bee
Amel\GB41681
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP12754
Bombus terrestris
Buff-tailed bumblebee
Bter\15206724
Linepithema humile
Argentine ant
Lhum\LH22858
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:000d0c
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG002432
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_09456
Tribolium castaneum
Red flour beetle
Tcas\TC005830
Pediculus humanus
Human body louse
Phum\PHUM494780
Rhodnius prolixus
Kissing bug
Rpro\RPRC010045
Cimex lectularius
Bed bug
Clec\CLEC001973
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI000942
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_04923
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0137 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR004637
Ixodes scapularis
Black-legged tick
Isca\ISCW012910
Stegodyphus mimosarum
African social velvet spider
Smim\KFM58103.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM58105.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM58104.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur03g05550
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_197351
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G01OY )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-GBF1
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Gbf1L
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000004296
Gallus gallus
Domestic chicken
Ggal\GBF1
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v7.1)
Drosophila melanogaster (Fruit fly) (6)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
Sec71
4 of 10
step
4 of 10
Efa6
3 of 10
siz
3 of 10
CG5937
2 of 10
mon2
2 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 1 )
    Allele
    Disease
    Interaction
    References
    garzEP2028
    exacerbates  tauopathy
    modeled by Hsap\MAPTV337M.UAS
    (Shulman and Feany, 2003)
    Disease Associations of Human Orthologs (via DIOPT v7.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    GBF1; golgi brefeldin A resistant guanine nucleotide exchange factor 1
    15 of 15
    603698
         
        ARFGEF1; ADP ribosylation factor guanine nucleotide exchange factor 1
        3 of 15
        604141
            ARFGEF2; ADP ribosylation factor guanine nucleotide exchange factor 2
            3 of 15
            605371
            Functional Complementation Data
            Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
            Dmel gene
            Ortholog showing functional complementation
            Supporting References
            garz
            Hsap\GBF1
            (Armbruster and Luschnig, 2012)
            Interactions
            Summary of Physical Interactions
            esyN Network Diagram
            Show neighbor-neighbor interactions:
            Select Layout:
            Legend:
            Protein
            RNA
            Selected Interactor(s)
            Interactions Browser
            View in Interactions Browser
            Please see the Physical Interaction reports below for full details
            protein-protein
            Physical Interaction
            Assay
            References
            garz - Arf79F
            pull down, peptide massfingerprinting
            (Christis and Munro, 2012)
            garz - Rab1
            anti tag coimmunoprecipitation, western blot, pull down, peptide massfingerprinting
            (Sechi et al., 2017, Gillingham et al., 2014)
            garz - Rab6
            pull down, peptide massfingerprinting
            (Gillingham et al., 2014)
            Summary of Genetic Interactions
            esyN Network Diagram
            esyN Network Key:
            Suppression
            Enhancement
            View in Interactions Browser
            Please look at the allele data for full details of the genetic interactions
            Starting gene(s)
            Interaction type
            Interacting gene(s)
            Reference
            garz
            enhanceable
            Arf79F
            (Armbruster and Luschnig, 2012)
            garz
            enhanceable
            Cds
            (Raghu et al., 2009)
            garz
            suppressible
            Vps35
            (Thakur et al., 2016)
            Starting gene(s)
            Interaction type
            Interacting gene(s)
            Reference
            Cds
            enhanceable
            garz
            (Raghu et al., 2009)
            Pld
            suppressible
            garz
            (Thakur et al., 2016)
            Pld
            enhanceable
            garz
            (Raghu et al., 2009)
            External Data
            Linkouts
            DroID - A comprehensive database of gene and protein interactions.
            MIST (genetic) - An integrated Molecular Interaction Database
            MIST (protein-protein) - An integrated Molecular Interaction Database
            Pathways
            Signaling Pathways (FlyBase)
            Metabolic Pathways
            External Data
            Linkouts
            KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
            Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
            Genomic Location and Detailed Mapping Data
            Chromosome (arm)
            2R
            Recombination map

            2-66

            Cytogenetic map
            48F8-48F10
            Sequence location
            2R:12,326,360..12,333,860 [+]
            FlyBase Computed Cytological Location
            Cytogenetic map
            Evidence for location
            48F8-48F10
            Limits computationally determined from genome sequence between P{EP}garzEP2028 and P{lacW}l(2)k11404k11404
            Experimentally Determined Cytological Location
            Cytogenetic map
            Notes
            References
            Experimentally Determined Recombination Data
            Location

            2-66

            (FlyBase, 2016)

            2-68.3

            (Comeron et al., 2012)

            2-10.5

            (Reuter and Szidonya, 1983)
            Left of (cM)
            Right of (cM)
            Notes
            Stocks and Reagents
            Stocks (9)
            Genomic Clones (19)
            cDNA Clones (25)
             

            Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

            cDNA clones, fully sequences
            BDGP DGC clones
            Other clones
              Drosophila Genomics Resource Center cDNA clones

              For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

              cDNA Clones, End Sequenced (ESTs)
              BDGP DGC clones
              Other clones
              RNAi and Array Information
              Linkouts
              GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
              Antibody Information
              Laboratory Generated Antibodies
               

              polyclonal

              (Wang et al., 2012)
              Commercially Available Antibodies
               
              Other Information
              Relationship to Other Genes
              Source for database identify of

              Source for identity of: garz CG8487

              (Kraut, 2002.3.6)
              Source for database merge of

              Source for merge of: garz ang

              (Armbruster and Luschnig, 2012)
              Additional comments
              Other Comments

              garz is not involved in invagination or in the elongation of salivary gland cells, but is involved in apical membrane expansion.

              (Wang et al., 2012)

              garz depletion inhibits AP-1 recruitment to membranes.

              (Szul et al., 2011)

              S2 cells treated with dsRNA generated against this gene show reduced phagocytosis of Candida albicans compared to untreated cells.

              (Stroschein-Stevenson et al., 2006)

              dsRNA made from templates generated with primers directed against garz that is transfected into S2 treated with Listeria monocytogenes reveals garz to be involved in Listeria monocytogenes entry.

              (Cheng et al., 2005)

              dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.

              (Kiger et al., 2003)

              Identification: in a screen for genes which when overexpressed cause motorneuron pathfinding and or synaptogenesis errors.

              (Kraut and Zinn, 2001)

              Involved in endocytosis/membrane trafficking.

              (Kraut and Zinn, 2001)
              Origin and Etymology
              Discoverer

              Mittler and Goldberg, 16th Sep. 1948.

              Etymology

              The gene is named "angina" based on the narrow tracheal lumen phenotype seen in mutant embryos.

              (Armbruster and Luschnig, 2012)
              Identification
              External Crossreferences and Linkouts ( 35 )
              Sequence Crossreferences
              NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
              GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
              GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
              RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
              UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
              Other crossreferences
              BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
              Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
              Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
              Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
              GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
              iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
              InterPro - A database of protein families, domains and functional sites
              KEGG Genes - Molecular building blocks of life in the genomic space.
              Linkouts
              DroID - A comprehensive database of gene and protein interactions.
              KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
              MIST (genetic) - An integrated Molecular Interaction Database
              MIST (protein-protein) - An integrated Molecular Interaction Database
              Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
              Synonyms and Secondary IDs (14)
              Reported As
              Symbol Synonym
              ARF1GEF
              (Khadilkar et al., 2014)
              ArfGEF
              (Wang et al., 2012)
              CG 8487
              (Kraut et al., 2001, Kraut et al., 2001)
              CG8487
              (Hosono et al., 2015, Sing et al., 2014, Armbruster and Luschnig, 2012, Christis and Munro, 2012, Wang et al., 2012, Ni et al., 2011.7.19, Gupta et al., 2009, Ni et al., 2008, Cox et al., 2004, Shulman and Feany, 2003)
              GBF1
              (Cox et al., 2004)
              GEF
              (Khadilkar et al., 2014)
              Garz
              (Sechi et al., 2017, Sopko et al., 2015, Khadilkar et al., 2014, D'Ambrosio and Vale, 2010)
              ang
              (Armbruster and Luschnig, 2012)
              garz
              (Singh et al., 2019, Sinha et al., 2019, Zeledon et al., 2019, Wilmes et al., 2018, Kim et al., 2017, Öztürk-Çolak et al., 2016, Chang et al., 2015, Zirin et al., 2015, Khadilkar et al., 2014, Lee et al., 2013, Armbruster and Luschnig, 2012, Christis and Munro, 2012, Japanese National Institute of Genetics, 2012.5.21, Reid et al., 2012, Wang et al., 2012, Szul et al., 2011, Gan et al., 2010, Kühnlein, 2010, Wendler et al., 2010, Gupta et al., 2009, Maybeck and Röper, 2009, Raghu et al., 2009, Telonis-Scott et al., 2009, Guo et al., 2008, Bakal et al., 2007, Gabut et al., 2007, McIntyre et al., 2006, Stroschein-Stevenson et al., 2006)
              Name Synonyms
              Gartenzwerg
              (Khadilkar et al., 2014, Szul et al., 2011, Kraut and Zinn, 2001)
              angina
              (Armbruster and Luschnig, 2012)
              angle wing
              gartenzwerg
              (Khadilkar et al., 2014, Armbruster and Luschnig, 2012, Reid et al., 2012, Wang et al., 2012, Kühnlein, 2010, Gupta et al., 2009, Gabut et al., 2007, Kraut, 2002.3.6)
              sec7-family GEF
              (Kraut et al., 2001, Kraut et al., 2001)
              Secondary FlyBase IDs
              • FBgn0033714
              • FBgn0063599
              • FBgn0000081
              Datasets (0)
              Study focus (0)
              Experimental Role
              Project
              Project Type
              Title
              References (79)