CG 8487, sec7-family GEF, ang
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Gene model reviewed during 5.49
None of the polypeptides share 100% sequence identity.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\garz using the Feature Mapper tool.
Comment: maternally deposited
Isoform-specific expression patterns are observed. Sex-specific expression of alternative transcripts observed.
GBrowse - Visual display of RNA-Seq signals
View Dmel\garz in GBrowse 22-66
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Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for identity of: garz CG8487
Source for merge of: garz ang
garz is not involved in invagination or in the elongation of salivary gland cells, but is involved in apical membrane expansion.
garz depletion inhibits AP-1 recruitment to membranes.
S2 cells treated with dsRNA generated against this gene show reduced phagocytosis of Candida albicans compared to untreated cells.
dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
Identification: in a screen for genes which when overexpressed cause motorneuron pathfinding and or synaptogenesis errors.
Involved in endocytosis/membrane trafficking.
Mittler and Goldberg, 16th Sep. 1948.
The gene is named "angina" based on the narrow tracheal lumen phenotype seen in mutant embryos.