FlyBase Gene Report: Dmel\CaMKII

General Information

Symbol

Dmel\CaMKII

Species

D. melanogaster

Name

Calcium/calmodulin-dependent protein kinase II

Annotation Symbol

CG18069

Feature Type

protein_coding_gene

FlyBase ID

FBgn0264607

Gene Model Status

Stock Availability

16 publicly available

Enzyme Name (EC)

Calcium/calmodulin-dependent protein kinase (2.7.11.17)

Gene Summary

Calcium/calmodulin-dependent protein kinase II (CaMKII) encodes an abundant Ca[2+]-calmodulin-regulated serine/threonine protein kinase. In neurons it has a wide range of substrates in multiple subcellular compartments, regulating synaptic plasticity, excitability and cytoskeletal interactions. [Date last reviewed: 2019-03-07] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
UniProtKB
Interactive Fly

Also Known As

dCaMKII, Ca2+/calmodulin-dependent protein kinase II, CaM kinase II, l(4)16, CaM kinase

Key Links

Genomic Location

Cytogenetic map

Sequence location

4:1,035,288..1,053,703 [-]

Recombination map

4-0

RefSeq locus

NC_004353 REGION:1035288..1053703

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse GBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

Gene Ontology (GO) Annotations (25 terms)

Molecular Function (4 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

enables calmodulin-dependent protein kinase activity

inferred from direct assay

(Cho et al., 1991)

enables protein serine/threonine kinase activity

inferred from direct assay

(Rajan et al., 2017, Koh et al., 1999)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

enables ATP binding

inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR002290, InterPro:IPR017441

(assigned by InterPro )

(FlyBase Curators et al., 2004-)

enables calmodulin binding

inferred from biological aspect of ancestor with PANTHER:PTN002389359

(assigned by GO_Central )

(Gaudet et al., 2011)

traceable author statement

(Montell, 1999)

enables calmodulin-dependent protein kinase activity

inferred from biological aspect of ancestor with PANTHER:PTN002389359

(assigned by GO_Central )

(Gaudet et al., 2011)

Biological Process (15 terms)

Terms Based on Experimental Evidence (12 terms)

CV Term

Evidence

References

involved_in cellular response to starvation

inferred from mutant phenotype

(Rajan et al., 2017)

involved_in chemical synaptic transmission

inferred from mutant phenotype

(Koh et al., 1999)

involved_in learning or memory

inferred from mutant phenotype

(Griffith et al., 1993)

involved_in long-term memory

inferred from mutant phenotype

(Malik et al., 2013, Chen et al., 2012, Ashraf et al., 2006)

involved_in male courtship behavior

inferred from mutant phenotype

(Mehren and Griffith, 2006, Mehren and Griffith, 2004)

involved_in negative regulation of cytokine production

inferred from mutant phenotype

(Rajan et al., 2017)

involved_in negative regulation of lipid storage

inferred from mutant phenotype

(Rajan et al., 2017)

involved_in peptidyl-threonine autophosphorylation

inferred from direct assay

(Rajan et al., 2017)

acts_upstream_of_positive_effect positive regulation of synaptic transmission, dopaminergic

inferred from mutant phenotype

(assigned by UniProt )

(Ravi et al., 2018)

involved_in regulation of filopodium assembly

inferred from mutant phenotype

(Andersen et al., 2005)

involved_in regulation of ovulation

inferred from genetic interaction with FLYBASE:Oamb; FB:FBgn0024944

(Lee et al., 2009)

involved_in regulation of synaptic assembly at neuromuscular junction

inferred from mutant phenotype

(Nesler et al., 2016, Gillespie and Hodge, 2013)

Terms Based on Predictions or Assertions (4 terms)

CV Term

Evidence

References

involved_in courtship behavior

traceable author statement

(Sokolowski, 2001)

involved_in learning or memory

non-traceable author statement

(Sokolowski, 2001)

involved_in neuromuscular junction development

non-traceable author statement

(Sokolowski, 2001)

involved_in protein phosphorylation

traceable author statement

(Montell, 1999)

Cellular Component (6 terms)

Terms Based on Experimental Evidence (5 terms)

CV Term

Evidence

References

located_in axon

inferred from direct assay

(Ashraf et al., 2006)

located_in cytoplasm

inferred from high throughput direct assay

(Lye et al., 2014)

located_in dendrite

inferred from direct assay

(Ashraf et al., 2006)

located_in postsynaptic membrane

inferred from direct assay

(Ashraf et al., 2006)

located_in presynaptic active zone

inferred from direct assay

(Ashraf et al., 2006)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

is_active_in cytoplasm

inferred from biological aspect of ancestor with PANTHER:PTN002389359

(assigned by GO_Central )

(Gaudet et al., 2011)

is_active_in neuron projection

inferred from biological aspect of ancestor with PANTHER:PTN002389359

(assigned by GO_Central )

(Gaudet et al., 2011)

Gene Group (FlyBase)

CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASES

Protein Family (UniProt)

Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily. (Q00168)

Protein Signatures (InterPro)

Catalytic Activity (EC)

Experimental Evidence

ATP + a protein = ADP + a phosphoprotein (2.7.11.17)

Predictions / Assertions

ATP + a protein = ADP + a phosphoprotein (2.7.11.17)

Summaries

Gene Snapshot

Calcium/calmodulin-dependent protein kinase II (CaMKII) encodes an abundant Ca[2+]-calmodulin-regulated serine/threonine protein kinase. In neurons it has a wide range of substrates in multiple subcellular compartments, regulating synaptic plasticity, excitability and cytoskeletal interactions. [Date last reviewed: 2019-03-07]

Gene Group (FlyBase)

CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASES -: The Calcium/Calmodulin-dependent kinase family are serine/threonine kinases which, in general, prefer substrates containing basic residues. Many, but not all, members are regulated by calcium or calmodulin. (Adapted from FBrf0132098).

Protein Function (UniProtKB)

A key regulator of plasticity in synaptic physiology and behavior, alterations in its activity produce pleiotrophic effects that involve synaptic transmission and development as well as various aspects of behavior. Directly modulates eag potassium channels.

(UniProt, Q00168)

Summary (Interactive Fly)

Interactive Fly

Gene Model and Products

Number of Transcripts

12

Number of Unique Polypeptides

8

Please see the JBrowse view of Dmel\CaMKII for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure New Section

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q00168)

If you don't see the viewer to the right, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Annotated transcripts do not represent all supported alternative splices within 5' UTR.

Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.

Gene model reviewed during 5.46

Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated

Evidence supports alternative transcription start site within intronic TE (RAMPAGE TSS data, FBrf0220331; short-capped RNA data, FBrf0209722; RNA-Seq junction data). May be specific to sequenced strain; not included in gene model.

Sequence Ontology: Class of Gene

gene_with_edited_transcript

(Rodriguez et al., 2012)

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

FBtr0089218

3589

490

FBtr0089219

3730

509

FBtr0089217

3759

490

FBtr0100146

3879

530

FBtr0100147

3816

509

FBtr0100148

3837

516

FBtr0300377

2371

490

FBtr0300378

3775

530

FBtr0300379

1845

531

FBtr0333673

3735

482

FBtr0333674

3855

522

FBtr0333675

3801

504

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

FBpp0088282

55.5

490

7.48

FBpp0088283

57.6

509

7.34

FBpp0088281

55.5

490

7.48

FBpp0099496

59.9

530

7.46

FBpp0099497

57.6

509

7.34

FBpp0099498

58.4

516

7.48

FBpp0289606

55.5

490

7.48

FBpp0289607

59.9

530

7.46

FBpp0289608

60.0

531

7.46

FBpp0305829

54.7

482

7.22

FBpp0305830

59.0

522

7.33

FBpp0305831

57.1

504

7.33

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

530 aa isoforms: CaMKII-PD, CaMKII-PI

509 aa isoforms: CaMKII-PB, CaMKII-PE

490 aa isoforms: CaMKII-PA, CaMKII-PC, CaMKII-PH

Additional Polypeptide Data and Comments

Reported size (kDa)

530, 516, 509, 490 (aa); 60, 58, 55 (kD)

(Ohsako et al., 1993)

490 (aa); 55 (kD)

(Cho et al., 1991)

Comments

There are four forms of CaMKII kinase which differ by insertions or deletions near the carboxy terminus of the putative link segment which is thought to join the amino- and carboxy-terminal globules. They were purified from transfected mammalian cells and Drosophila head extracts and their catalytic properties described. Catalytic activity is dependent on Ca²⁺ and calmodulin before autophosphorylation. Ca²⁺-independent activity is observed after autophosphorylation.

(Ohsako et al., 1993)

There are four forms of CaMKII kinase which differ by insertions or deletions near the carboxy terminus of the putative link segment which is thought to join the amino and carboxy-terminal globules. They were purified from transfected mammalian cells and Drosophila head extracts and their catalytic properties described. Catalytic activity is dependent on Ca²⁺ and calmodulin before autophosphorylation. Ca²⁺-independent activity is observed after autophosphorylation.

(Ohsako et al., 1993)

There are four forms of CaMKII kinase which differ by insertions or deletions near the carboxy terminus of the putative link segment which is thought to join the amino and carboxy-terminal globules. They were purified from transfected mammalian cells and Drosophila head extracts and their catalytic properties described. Catalytic activity is dependent on Ca²⁺ and calmodulin before autophosphorylation. Ca²⁺-independent activity is observed after autophosphorylation. The 516aa isoform is a minor form in adult heads.

(Ohsako et al., 1993)

One of several products generated by alternative splicing.

(FlyBase, 1992-)

CaMKII protein purified 200-fold from adult Drosophila heads was shown to have kinase activity and to aquire Ca²⁺-independent activity after autophosphorylaton. CaMKII protein expressed from a Drosophila cDNA in COS cells was shown to have the same properties. Four autophosphorylation sites are conserved between the rat and the Drosophila enzymes.

(Cho et al., 1991)

External Data

Subunit Structure (UniProtKB)

Interacts with CASK.

(UniProt, Q00168)

Post Translational Modification

Autophosphorylation at Thr-287 is independent of autophosphorylation at Thr-306 and Thr-307.

(UniProt, Q00168)

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\CaMKII using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

CaMKII_1

Linkouts

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

No Assay Recorded

Stage

Tissue/Position (including subcellular localization)

Reference

(Ohsako et al., 1993, Cho et al., 1991)

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism | intense | ubiquitous

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 4 -- 6

Comment: rapidly degraded

(Fisher et al., 2012)

organism | intense | ubiquitous

(Fisher et al., 2012)

embryonic stage 5 -- 7

organism | uniform

(Rachidi et al., 1999)

embryonic stage 7 -- 8

organism | faint | ubiquitous

(Fisher et al., 2012)

embryonic stage 8 -- 11

(Rachidi et al., 1999)

embryonic stage 8 -- 12

posterior midgut primordium

(Rachidi et al., 1999)

anterior midgut primordium

(Rachidi et al., 1999)

embryonic stage 9 -- 10

anterior endoderm

(Fisher et al., 2012)

organism | ubiquitous

(Fisher et al., 2012)

posterior endoderm

(Fisher et al., 2012)

embryonic stage 10 -- 12

posterior midgut primordium

(Ohsako et al., 1993)

anterior midgut primordium

(Ohsako et al., 1993)

embryonic stage 10 -- 14

embryonic neuroblast

(Rachidi et al., 1999)

embryonic stage 11 -- 12

anterior midgut primordium

(Fisher et al., 2012)

central brain primordium

(Fisher et al., 2012)

organism | ubiquitous

(Fisher et al., 2012)

posterior midgut primordium

(Fisher et al., 2012)

ventral nerve cord primordium

(Fisher et al., 2012)

embryonic stage 12 -- 15

presumptive embryonic/larval central nervous system

(Ohsako et al., 1993)

embryonic stage 13

midgut primordium

(Rachidi et al., 1999)

embryonic stage 13 -- 16

embryonic brain

(Fisher et al., 2012)

embryonic/larval midgut

(Fisher et al., 2012)

organism | ubiquitous

(Fisher et al., 2012)

larval ventral nerve cord

(Fisher et al., 2012)

embryonic stage 14 -- 17

embryonic/larval central nervous system

(Rachidi et al., 1999)

antenno-maxillary complex

(Rachidi et al., 1999)

embryonic stage 16 -- 17

embryonic/larval central nervous system

(Ohsako et al., 1993)

embryonic/larval peripheral nervous system

(Ohsako et al., 1993)

first instar larval stage

embryonic/larval central nervous system | uniform

(Rachidi et al., 1999)

second instar larval stage -- third instar larval stage

thoracic segment of larval ventral nerve cord

(Rachidi et al., 1999)

embryonic/larval brain

(Rachidi et al., 1999)

prepupal stage P1

embryonic/larval brain

(Rachidi et al., 1999)

(Rachidi et al., 1999)

adult optic lobe

(Rachidi et al., 1999)

supraesophageal ganglion

(Rachidi et al., 1999)

(Rachidi et al., 1999)

(Rachidi et al., 1999)

adult optic lobe neuron

(Rachidi et al., 1999)

neuron of fan-shaped body

(Rachidi et al., 1999)

neuron of ellipsoid body

(Rachidi et al., 1999)

northern blot

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 9 -- 17

(Ohsako et al., 1993)

Additional Descriptive Data

CaMKII transcripts from very early embryos have only the short 3' UTR form while adult heads have both the long and short 3' UTR forms.

(Kuklin et al., 2017)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

No Assay Recorded

Stage

Tissue/Position (including subcellular localization)

Reference

(Cho et al., 1991)

enzyme assay or biochemical detection

Stage

Tissue/Position (including subcellular localization)

Reference

(Lu et al., 2009)

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 16

embryonic/larval hypodermal muscle cell | faint | uniform

Comment: 14 hr AEL

(Kazama et al., 2003)

embryonic stage 17

embryonic/larval hypodermal muscle cell | faint

Comment: 17-22 hr AEL

(Kazama et al., 2003)

muscle cell of A1-7 ventral longitudinal muscle 1 | faint

Comment: 17-22 hr AEL

(Kazama et al., 2003)

muscle cell of A1-7 ventral longitudinal muscle 2 | faint

Comment: 17-22 hr AEL

(Kazama et al., 2003)

muscle cell of A1-7 ventral longitudinal muscle 3 | faint

Comment: 17-22 hr AEL

(Kazama et al., 2003)

muscle cell of A1-7 ventral longitudinal muscle 4 | faint

Comment: 17-22 hr AEL

(Kazama et al., 2003)

embryonic stage 17(i)

• terminal bouton

Comment: 17 hr AEL

(Kazama et al., 2003)

• axon

Comment: 17 hr AEL

(Kazama et al., 2003)

embryonic stage 17(iv)

• terminal bouton | intense

Comment: 22 hr AEL

(Kazama et al., 2003)

muscle cell of A1-7 ventral longitudinal muscle 1

• postsynaptic density | intense

Comment: 22 hr AEL

(Kazama et al., 2003)

muscle cell of A1-7 ventral longitudinal muscle 2

• postsynaptic density | intense

Comment: 22 hr AEL

(Kazama et al., 2003)

muscle cell of A1-7 ventral longitudinal muscle 3

• postsynaptic density | intense

Comment: 22 hr AEL

(Kazama et al., 2003)

muscle cell of A1-7 ventral longitudinal muscle 4

• postsynaptic density | intense

Comment: 22 hr AEL

(Kazama et al., 2003)

neuron | subset of adult brain

(Chen et al., 2012)

dorsal anterior lateral neuron of the protocerebrum

(Chen et al., 2012)

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

• membrane

(Aradska et al., 2015)

day 7 of adulthood -- day 49 of adulthood

(Cammarato et al., 2011)

western blot

Stage

Tissue/Position (including subcellular localization)

Reference

(Ohsako et al., 1993)

(Lu et al., 2009)

Additional Descriptive Data

CaMkII protein is expressed uniformly in body wall muscles at 14 hrs AEL. By 22 hrs AEL, CaMKII can be faintly detected in the axons and terminal buttons of motor neurons innervating the A1-7 ventral longitudinal muscles 1-4 (muscles 6, 7, 12 and 13). By 22 hrs AEL, CamKII immunoreactivity intensely labels the motor neuron terminal buttons, and the corresponding postsynaptic densities.

(Kazama et al., 2003)

CaMKII protein is expressed at much greater levels in adult head than body.

(Cho et al., 1991)

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in axon

inferred from direct assay

(Ashraf et al., 2006)

located_in cytoplasm

inferred from high throughput direct assay

(Lye et al., 2014)

located_in dendrite

inferred from direct assay

(Ashraf et al., 2006)

located_in postsynaptic membrane

inferred from direct assay

(Ashraf et al., 2006)

located_in presynaptic active zone

inferred from direct assay

(Ashraf et al., 2006)

Expression Deduced from Reporters

Reporter: P{CaMKII-GAL4.7}

Stage

Tissue/Position (including subcellular localization)

Reference

neuron | subset of adult brain

(Chen et al., 2012)

dorsal anterior lateral neuron of the protocerebrum

Comment: strong expression

(Chen et al., 2012)

adult mushroom body

Comment: strong expression

(Chen et al., 2012)

Comment: faint expression

(Chen et al., 2012)

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\CaMKII in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\CaMKII

View exonic expression by tissue for Dmel\CaMKII

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0264607

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

43828/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0264607

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0004624

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0264607

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG18069

Images

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 21 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 23 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of CaMKII

Transgenic constructs containing regulatory region of CaMKII

Aberrations (Deficiencies and Duplications) ( 7 )

Inferred from experimentation ( 7 )

Gene not disrupted in

(Hochman, 1976, Hochman, 1974, Hochman, 1971)

(Hochman, 1971)

Gene disrupted in

(Hochman, 1976, Hochman, 1974, Hochman, 1971)

(Hochman, 1976, Hochman, 1974, Hochman, 1971)

(Hochman, 1976, Hochman, 1974, Hochman, 1971)

(Hochman, 1976, Hochman, 1974, Hochman, 1971)

(Hochman, 1976, Hochman, 1974, Hochman, 1971)

Inferred from location ( 0 )

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal, with Scer\GAL4^29BD, Tn10\tetR^tTA.UAS

CaMKII^T287D.tetO

lethal, with Scer\GAL4^Appl.G1a

CaMKII^T287D.UAS

lethal, with Scer\GAL4^elav-C155

CaMKII^T287D.UAS

lethal, with Scer\GAL4^elav-C155, Tn10\tetR^tTA.UAS

CaMKII^T287D.tetO

lethal, with Scer\GAL4^MJ85b, Tn10\tetR^tTA.UAS

CaMKII^T287D.tetO

lethal | recessive

partially lethal, with Scer\GAL4^tin.CΔ4

CaMKII^GD9506

viable, with Scer\GAL4^Appl.G1a

CaMKII^T287A.UAS

viable, with Scer\GAL4^elav-C155

CaMKII^T287A.UAS

viable, with Scer\GAL4^Mef2.PR

CaMKII^GD9506

viable, with Scer\GAL4^pnr-MD237

CaMKII^GD9506

Sterility

Allele

female semi-sterile, with Scer\GAL4^nos.PG, Scer\GAL4^VP16.nos.UTR, Scer\GAL4^VP16.otu

CaMKII^GL00237

Other Phenotypes

Allele

abnormal courtship behavior, with Scer\GAL4^30Y, Tn10\tetR^tTA.UAS

CaMKII^T287D.tetO

abnormal courtship behavior, with Scer\GAL4^MJ85b, Tn10\tetR^tTA.UAS

CaMKII^T287D.tetO

abnormal courtship behavior | male | tetracycline conditional, with Scer\GAL4^30Y, Scer\GAL80^ChAT.3.3P, Tn10\tetR^tTA.UAS

CaMKII^T287D.tetO

abnormal courtship behavior | male | tetracycline conditional, with Scer\GAL4^30Y, Tn10\tetR^tTA.UAS

CaMKII^T287D.tetO

abnormal locomotor behavior | third instar larval stage, with Scer\GAL4^Appl.G1a

CaMKII^T287D.UAS

abnormal locomotor behavior | third instar larval stage, with Scer\GAL4^elav-C155

CaMKII^T287D.UAS

abnormal memory, with Scer\GAL4^c305a

abnormal memory, with Scer\GAL4^CaMKII.7

CaMKII^dsRNA.UAS

abnormal memory, with Scer\GAL4^ey-OK107

abnormal memory, with Scer\GAL4^G0431

CaMKII^dsRNA.UAS

abnormal memory, with Scer\GAL4^Mef2.247

CaMKII^dsRNA.UAS

abnormal neuroanatomy, with Scer\GAL4^109(2)80

abnormal neuroanatomy, with Scer\GAL4^Toll-6-D42

CaMKII^T287D.UAS

abnormal neuroanatomy, with Scer\GAL4^unspecified

CaMKII^T287D.UAS

abnormal neuroanatomy | larval stage, with Scer\GAL4^Toll-6-D42

CaMKII^T287D.UAS

abnormal neuroanatomy | somatic clone, with Scer\FLP1^UAS.cUa, Scer\GAL4^Act.PU, Scer\GAL4^eve.RRK

CaMKII^T287D.UAS

abnormal neuroanatomy | third instar larval stage, with Scer\GAL4^VGlut-OK371

abnormal neurophysiology, with Scer\GAL4^Appl.G1a

CaMKII^T287D.UAS

abnormal neurophysiology, with Scer\GAL4^elav-C155

CaMKII^T287D.UAS

abnormal neurophysiology, with Scer\GAL4^Toll-6-D42

CaMKII^T287D.UAS

abnormal neurophysiology | third instar larval stage

CaMKII^stopw+

abnormal neurophysiology | third instar larval stage, with Scer\GAL4^how-24B

CaMKII^T287D.UAS

abnormal pain response | adult stage, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

CaMKII^GD9506

abnormal size | larval stage, with Scer\GAL4^Toll-6-D42

CaMKII^T287D.UAS

decreased body size, with Scer\GAL4^MJ85b, Tn10\tetR^tTA.UAS

CaMKII^T287D.tetO

visible | adult stage, with Scer\GAL4^CCAP.PU

CaMKII^T287D.UAS

Phenotype manifest in

Allele

adult abdomen, with Scer\GAL4^29BD, Tn10\tetR^tTA.UAS

CaMKII^T287D.tetO

adult heart, with Scer\GAL4^tin.CΔ4

CaMKII^UAS.cKa

axon, with Scer\GAL4^Toll-6-D42

CaMKII^T287D.UAS

axon | larval stage, with Scer\GAL4^Toll-6-D42

CaMKII^T287D.UAS

bouton, with Scer\GAL4^Toll-6-D42

CaMKII^T287D.UAS

bouton | increased number, with Scer\GAL4^elav-C155

CaMKII^T287D.UAS

dendrite | somatic clone, with Scer\FLP1^UAS.cUa, Scer\GAL4^Act.PU, Scer\GAL4^eve.RRK

CaMKII^T287D.UAS

embryonic/larval neuromuscular junction, with Scer\GAL4^elav-C155

CaMKII^T287D.UAS

embryonic/larval neuromuscular junction | third instar larval stage, with Scer\GAL4^how-24B

CaMKII^T287D.UAS

filopodium & dendrite, with Scer\GAL4^109(2)80

motor neuron, with Scer\GAL4^Toll-6-D42

CaMKII^T287D.UAS

neuromuscular junction, with Scer\GAL4^unspecified

CaMKII^T287D.UAS

neuromuscular junction & bouton, with Scer\GAL4^unspecified

CaMKII^T287D.UAS

neuromuscular junction & postsynaptic membrane, with Scer\GAL4^unspecified

CaMKII^T287D.UAS

neuromuscular junction | larval stage, with Scer\GAL4^Toll-6-D42

CaMKII^T287D.UAS

presynaptic active zone | larval stage, with Scer\GAL4^Toll-6-D42

CaMKII^T287D.UAS

RP2 motor neuron | somatic clone, with Scer\FLP1^UAS.cUa, Scer\GAL4^Act.PU, Scer\GAL4^eve.RRK

CaMKII^T287D.UAS

synapse, with Scer\GAL4^Toll-6-D42

CaMKII^T287D.UAS

type Ib terminal bouton | third instar larval stage, with Scer\GAL4^VGlut-OK371

wing, with Scer\GAL4^29BD, Tn10\tetR^tTA.UAS

CaMKII^T287D.tetO

wing, with Scer\GAL4^CCAP.PU

CaMKII^T287D.UAS

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v8.0)

Homo sapiens (Human) (21)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

13 of 15

Yes

Yes

1

10 of 15

No

Yes

2

9 of 15

No

Yes

3

9 of 15

No

Yes

2 of 15

No

No

1

2 of 15

No

No

2 of 15

No

No

2 of 15

No

No

2 of 15

No

No

1

1 of 15

No

No

1 of 15

No

No

2

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

Model Organism Orthologs (via DIOPT v8.0)

Mus musculus (laboratory mouse) (20)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

13 of 15

Yes

Yes

11 of 15

No

Yes

10 of 15

No

Yes

1

10 of 15

No

Yes

2 of 15

No

No

2 of 15

No

No

2 of 15

No

No

2 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

Rattus norvegicus (Norway rat) (21)

11 of 13

Yes

Yes

9 of 13

No

Yes

7 of 13

No

Yes

4

7 of 13

No

Yes

2 of 13

No

No

2 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

Rnor\LOC100909586

1 of 13

No

Yes

Rnor\LOC102552324

1 of 13

No

Yes

1 of 13

No

No

Rnor\NEWGENE_621802

1 of 13

No

Yes

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

Xenopus tropicalis (Western clawed frog) (24)

9 of 12

Yes

Yes

7 of 12

No

Yes

6 of 12

No

Yes

5 of 12

No

Yes

1 of 12

No

No

1 of 12

No

No

1 of 12

No

No

1 of 12

No

No

1 of 12

No

No

1 of 12

No

No

1 of 12

No

No

1 of 12

No

No

1 of 12

No

No

1 of 12

No

No

Xtro\LOC100216185

1 of 12

No

Yes

Xtro\LOC100496389

1 of 12

No

Yes

Xtro\LOC101730432

1 of 12

No

Yes

1 of 12

No

No

1 of 12

No

No

1 of 12

No

No

1 of 12

No

No

1 of 12

No

No

1 of 12

No

No

1 of 12

No

No

Danio rerio (Zebrafish) (33)

11 of 15

Yes

Yes

9 of 15

No

Yes

9 of 15

No

Yes

9 of 15

No

Yes

8 of 15

No

Yes

8 of 15

No

Yes

4 of 15

No

Yes

2 of 15

No

No

2 of 15

No

No

2 of 15

No

No

2 of 15

No

No

2 of 15

No

No

2 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

Yes

Drer\LOC100537554

1 of 15

No

Yes

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

Drer\si:ch73-60h1.1

1 of 15

No

No

Drer\si:ch211-27e6.1

1 of 15

No

Yes

1 of 15

No

No

Caenorhabditis elegans (Nematode, roundworm) (8)

12 of 15

Yes

Yes

2 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

Arabidopsis thaliana (thale-cress) (46)

5 of 9

Yes

Yes

5 of 9

Yes

Yes

5 of 9

Yes

Yes

4 of 9

No

Yes

4 of 9

No

Yes

4 of 9

No

Yes

4 of 9

No

No

4 of 9

No

Yes

4 of 9

No

Yes

4 of 9

No

Yes

4 of 9

No

Yes

4 of 9

No

No

4 of 9

No

Yes

4 of 9

No

Yes

4 of 9

No

Yes

4 of 9

No

Yes

4 of 9

No

Yes

4 of 9

No

Yes

4 of 9

No

Yes

4 of 9

No

Yes

4 of 9

No

Yes

4 of 9

No

Yes

4 of 9

No

Yes

4 of 9

No

Yes

4 of 9

No

Yes

4 of 9

No

Yes

4 of 9

No

Yes

4 of 9

No

Yes

3 of 9

No

Yes

3 of 9

No

Yes

3 of 9

No

Yes

3 of 9

No

Yes

3 of 9

No

Yes

3 of 9

No

Yes

3 of 9

No

Yes

2 of 9

No

Yes

2 of 9

No

Yes

2 of 9

No

Yes

2 of 9

No

Yes

2 of 9

No

Yes

2 of 9

No

Yes

2 of 9

No

Yes

1 of 9

No

No

1 of 9

No

No

1 of 9

No

No

1 of 9

No

No

Saccharomyces cerevisiae (Brewer's yeast) (4)

4 of 15

Yes

No

2 of 15

No

No

1 of 15

No

No

1 of 15

No

No

Schizosaccharomyces pombe (Fission yeast) (2)

1 of 12

Yes

No

1 of 12

Yes

Yes

Other Organism Orthologs (via OrthoDB)

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v8.0)

Drosophila melanogaster (Fruit fly) (8)

Gene Symbol

Score

Source

Alignment

5 of 10

2 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 2 )

Allele

Disease

Evidence

References

model of neuromuscular disease

CEA with Hsap\TRPV4^{R269C.UAS.BID}

(Woolums et al., 2020)

model of heart conduction disease

CEA

(Konstantinidis et al., 2020)

Potential Models Based on Orthology ( 2 )

Human Ortholog

Disease

Evidence

References

CAMK2B; calcium/calmodulin dependent protein kinase II beta

model of autosomal dominant mental retardation 54

IEA

(FlyBase, 2019-)

CAMK2A; calcium/calmodulin dependent protein kinase II alpha

model of autosomal dominant mental retardation 53

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 4 )

Allele

Disease

Interaction

References

exacerbates tauopathy

modeled by Hsap\MAPT^UAS.cWa

(Oka et al., 2017)

CaMKII^KK107335

ameliorates neuromuscular disease

modeled by Hsap\TRPV4^R269C.UAS

(Woolums et al., 2020)

modeled by Hsap\TRPV4^UAS.cWa

(Woolums et al., 2020)

exacerbates Huntington's disease

modeled by Hsap\HTT^{128Q.1-336.UAS}

(Shirasaki et al., 2012)

ameliorates tauopathy

modeled by Hsap\MAPT^UAS.cWa

(Oka et al., 2017)

ameliorates neuromuscular disease

modeled by Hsap\TRPV4^R269C.UAS

(Woolums et al., 2020)

modeled by Hsap\TRPV4^UAS.cWa

(Woolums et al., 2020)

CaMKII^{dsRNA.UAS.cUa}

ameliorates neuromuscular disease

modeled by Hsap\TRPV4^R269C.UAS

(Woolums et al., 2020)

modeled by Hsap\TRPV4^UAS.cWa

(Woolums et al., 2020)

Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

CAMK2D; calcium/calmodulin dependent protein kinase II delta

13 of 15

CAMK2B; calcium/calmodulin dependent protein kinase II beta

10 of 15

MENTAL RETARDATION, AUTOSOMAL DOMINANT 54; MRD54

autosomal dominant mental retardation 54

CAMK2A; calcium/calmodulin dependent protein kinase II alpha

9 of 15

autosomal dominant mental retardation 53

CAMK2G; calcium/calmodulin dependent protein kinase II gamma

9 of 15

INTELLECTUAL DEVELOPMENTAL DISORDER, AUTOSOMAL DOMINANT 59; MRD59

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

View in Interactions Browser

Please see the Physical Interaction reports below for full details

RNA-protein

Physical Interaction

Assay

References

anti tag coimmunoprecipitation, primer specific pcr

(Sudhakaran et al., 2014)

anti tag coimmunoprecipitation, primer specific pcr

(Sudhakaran et al., 2014)

anti tag coimmunoprecipitation, quantitative reverse transcription pcr

(Bienkowski et al., 2017)

RNA-RNA

Physical Interaction

Assay

References

CaMKII - mir-289

luminiscence technology, necessary binding region

(Nesler et al., 2016)

protein-protein

Physical Interaction

Assay

References

enzymatic study, autoradiography, cosedimentation, molecular sieving

(Sun et al., 2004, Koh et al., 1999, Gupta Roy and Griffith, 1996)

enzymatic study, autoradiography

(Lu et al., 2009)

pull down, western blot, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation

(Lu et al., 2003)

pull down, competition binding, autoradiography, lambda phage display

(Xu et al., 1998, GuptaRoy et al., 1996)

CaMKII - Grasp65

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Rajan et al., 2017)

anti tag coimmunoprecipitation, Identification by mass spectrometry, anti tag western blot

(Formicola et al., 2021)

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

anti bait coimmunoprecipitation, covalent binding, western blot

(Long and Griffith, 2000)

(Long and Griffith, 2000)

anti bait coimmunoprecipitation, western blot, enzymatic study, autoradiography

(Koh et al., 1999)

pull down, western blot, anti bait coimmunoprecipitation, x-ray crystallography, enzymatic study, autoradiography, isothermal titration calorimetry, predetermined participant

(Castro-Rodrigues et al., 2018, Sun et al., 2004)

anti tag coimmunoprecipitation, Identification by mass spectrometry, anti tag western blot

(Ulian-Benitez et al., 2017)

(Long and Griffith, 2000)

anti bait coimmunoprecipitation, western blot, pull down

(Lu et al., 2009)

Summary of Genetic Interactions

esyN Network Diagram

esyN Network Key:

Suppression

Enhancement

View in Interactions Browser

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

enhanceable

(Pla et al., 1997)

suppressible

(Gillespie and Hodge, 2013, Malik et al., 2013)

suppressible

(Chun-Jen Lin et al., 2011)

enhanceable

(Pla et al., 1997)

suppressible

(Chun-Jen Lin et al., 2011)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

suppressible

(Malik et al., 2013)

suppressible

(Haghighi et al., 2003)

suppressible

(Ulian-Benitez et al., 2017)

suppressible

(Chun-Jen Lin et al., 2011)

suppressible

(Beumer et al., 2002)

suppressible

(Lee et al., 2009)

suppressible

(Lim et al., 2014)

enhanceable

(Park et al., 2002)

suppressible

(Ulian-Benitez et al., 2017)

suppressible

(Ulian-Benitez et al., 2017)

External Data

Subunit Structure (UniProtKB)

Interacts with CASK.

(UniProt, Q00168 )

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0264607

MIST (genetic) - An integrated Molecular Interaction Database

CaMKII

MIST (protein-protein) - An integrated Molecular Interaction Database

CaMKII

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0264607

External Data

Linkouts

KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Genomic Location and Detailed Mapping Data

Chromosome (arm)

4

Recombination map

4-0

Cytogenetic map

Sequence location

4:1,035,288..1,053,703 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

102F6-102F7

Left limit from inclusion within Df(4)3 (FBrf0022724) Right limit from inclusion within Df(4)38 (FBrf0022724)

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

102E-102F

(determined by in situ hybridisation)

(Cho et al., 1991)

Experimentally Determined Recombination Data

Location

4-0

(FlyBase, 2016)

4-1

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (16)

Aberrations including deletions of this gene Aberrations including duplications of this gene

29662

w^*; P{UAS-CaMKII.R3}2

29663

w^*; P{UAS-CaMKII.T287A}3B3

29664

w^*; P{UAS-CaMKII.T287D}6B1

29665

w^*; P{UAS-CaMKII.T287D}10A

60770

y¹; Mi{MIC}CaMKII^MI03976

29401

y¹ v¹; P{TRiP.JF03336}attP2

81692

y¹ v¹; P{TKO.GS03310}attP40

22325

y¹ w¹¹¹⁸; P{EPgy2}CaMKII^EY14097

v100265

P{KK107335}VIE-260B

v38930

w¹¹¹⁸ P{GD9506}v38930

v47280

w¹¹¹⁸; P{GD9506}v47280

v318306

PBac{fTRG00955.sfGFP-TVPTBF}VK00033

More stocks available...

Genomic Clones (25)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (401)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

FI03620

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0264607

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

43828

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Lu et al., 2009, Lu et al., 2003, Long and Griffith, 2000, Koh et al., 1999)

monoclonal

(Takamatsu et al., 2003)

Commercially Available Antibodies

Other Information

Relationship to Other Genes

Source for database identify of

Source for identity of: CaMKII CG18069

(Zhao, 1999.11)

Source for database merge of

Source for merge of: CaMKII l(4)102EFb

(Johnson et al., 2002)

Additional comments

Other Comments

Host gene for maternally inherited stable intronic sequence RNA (sisRNA).

(Tay and Pek, 2017)

Candidate stable intronic sequence RNA (sisRNA) identified within CDS of this gene.

(Pek et al., 2015)

CaMKII activity increases levels of p-Akt1 in larval motor nerve terminals in a Fak56D-dependent manner.

(Chun-Jen Lin et al., 2011)

Nonsense-mediated mRNA decay (NMD) down-regulates a distinct splice isoform(s) of this gene.

(Hansen et al., 2009)

dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R⁺ cell morphology.

(Kiger et al., 2003)

CaMKII protein phosphorylates eag protein at Thr-787.

(Wang et al., 2002)

dlg1 and CaMKII protein colocalise at synapses and exist in the same protein complex.

(Koh et al., 1999)

The CaMKII protein is the kinase that phosphorylates phosrestin 1, the product of the Arr2 gene. The earliest light induced phosphorylation in the photoreceptor is the phosphorylation of a single site of Arr2 by a kinase dependent on both Ca²⁺ and calmodulin. The kinase that is responsible for the phosphorylation of Arr2 is CaMKII. Results suggest CaMKII may play a role in regulating light adaptation in photoreceptors.

(Kahn and Matsumoto, 1997)

The basic catalytic functions of six CaMKII isoforms are characterised. Results reveal the protein family is functionally homologous to the rat CaM kinase II.

(Gupta Roy and Griffith, 1996)

Isoforms of CaMKII have similar biochemical properties, they exhibit differential activity by mutant Cam proteins. Data supports a role for the C-terminal variable region of CaMKII in the mechanism of activation and demonstrate that stimulation of CaMKII catalytic activity by Cam is a multistep process, with separate binding and activation steps.

(GuptaRoy et al., 1996)

A key regulator of plasticity in synaptic physiology and behaviour, alterations in its activity produce pleiotropic effects that involve synaptic transmission and development as well as various aspects of behaviour.

(Greenspan et al., 1995)

A fifth form of CaMKII is isolated, it is maternally derived and is identical to the 530 amino acid polypeptide except for the missing exon 11.

(Takamatsu et al., 1994)

Study of transformed lines expressing a specific inhibitor of CaMKII (Rat\CamKII-I) suggests an important role of CaMKII in the stability of synaptic transmission.

(Wang et al., 1994)

CaMKII is alternatively spliced, producing a variety of protein isoforms.

(Griffith and Greenspan, 1993)

CaMKII activity can be inhibited by a synthetic peptide corresponding to the rat autoinhibitory domain of CaM kinase. Results suggest that CaMKII activity is required for plastic behaviour in an intact animal.

(Griffith et al., 1993)

A large gene with at least 16 exons encoding 4 forms of Cam kinase by alternate splicing.

(Ohsako et al., 1993)

Origin and Etymology

Discoverer

Etymology

Identification

External Crossreferences and Linkouts ( 110 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

43828

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q00168

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

Q00168

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q00168

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0264607

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0264607

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

43828/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0264607

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

CaMKII_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0004624

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0264607

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG18069

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0264607

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

43828

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC002587

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

Dmel_CG18069

MARRVEL_MODEL - MARRVEL (model organism gene)

43828

SignaLink - A signaling pathway resource with multi-layered regulatory networks.

Q00168

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0264607

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.

MIST (genetic) - An integrated Molecular Interaction Database

CaMKII

MIST (protein-protein) - An integrated Molecular Interaction Database

CaMKII

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Synonyms and Secondary IDs (43)

Reported As

Symbol Synonym

CAMKII

(Anqueira-González et al., 2021, Wang et al., 2018, Neely et al., 2011, Kalinovsky and Scheiffele, 2004, Jasper et al., 2002)

CAMKIId

(Morrison et al., 2000)

CAMKIIα

(Sutton and Schuman, 2006)

CDPK1

(Winge, 1995.3.9)

CG18069

(Tay and Pek, 2017, Çiçek et al., 2016, Pek et al., 2015, Rosa-Ferreira et al., 2015, Kanamori et al., 2013, Cammarato et al., 2011, Ni et al., 2011.7.19, Khanna et al., 2010, Hansen et al., 2009, Keleman et al., 2009.8.5, Perkins et al., 2009, Talamillo et al., 2008, Morrison et al., 2000)

Ca2+/calmodulin-dependent protein kinase II

(Ohsako, 1993.3.4, Ohsako, 1993.3.4, Ohsako, 1993.3.4, Ohsako, 1993.3.4)

CaM

(Greenspan et al., 1995, Cho et al., 1991)

CaM II

(Coleman and Neckameyer, 2001)

CaM KII

(Ejima and Griffith, 2003, Rachidi et al., 1999)

CaM kinase

(Broughton et al., 1996)

CaMK II

(Weber et al., 2007, Kahn et al., 1998)

CaMK-II

(Tombes et al., 2003)

CaMKII

(Fourth Chromosome Resource Project and Newfeld, 2022-, Cavieres-Lepe and Ewer, 2021, Destalminil-Letourneau et al., 2021, Goel and Dickman, 2021, Khan et al., 2021, Kon et al., 2021, Lin et al., 2021, Shieh et al., 2021, Wang et al., 2021, Yeates and Frank, 2021, Aboukilila et al., 2020, Amourda and Saunders, 2020, Bai and Suzuki, 2020, Frank et al., 2020, Konstantinidis et al., 2020, Lee and Wu, 2020, Park et al., 2020, Robinson et al., 2020, Toprak et al., 2020, Vajente et al., 2020, Voolstra and Huber, 2020, Wang et al., 2020, Woolums et al., 2020, Zhao et al., 2020, Sethi et al., 2019, Su et al., 2019, Yildirim et al., 2019, Bakthavachalu et al., 2018, Ravi et al., 2018, Allen et al., 2017, Bienkowski et al., 2017, Busto et al., 2017, Kline et al., 2017, Kuklin et al., 2017, Oka et al., 2017, Rajan et al., 2017, Tay and Pek, 2017, Transgenic RNAi Project members, 2017-, Ulian-Benitez et al., 2017, Vonhoff and Keshishian, 2017, Zhu et al., 2017, Cannon and Bodmer, 2016, Flores-Benitez and Knust, 2016, Golovin and Broadie, 2016, Sarov et al., 2016, Wang et al., 2016, Lee et al., 2015, Ashwal-Fluss et al., 2014, Frank, 2014, Lim et al., 2014, Lye et al., 2014, Milakovic et al., 2014, Mukherjee et al., 2014, Santalla et al., 2014, Sopko et al., 2014, Sudhakaran et al., 2014, Gillespie and Hodge, 2013, Kanamori et al., 2013, Malik et al., 2013, Sadanandappa et al., 2013, Sartain and Wolfner, 2013, Tang et al., 2013, Timmerman et al., 2013, Vonhoff et al., 2013, Xiong and Bellen, 2013, Yin et al., 2013, Zhang et al., 2013, Chen et al., 2012, Chorna and Hasan, 2012, Japanese National Institute of Genetics, 2012.5.21, Kadas et al., 2012, Minke, 2012, Rodriguez et al., 2012, Shirasaki et al., 2012, Winbush et al., 2012, Chun-Jen Lin et al., 2011, Ping and Tsunoda, 2011, Shakiryanova et al., 2011, Tian et al., 2011, Wang et al., 2011, Akalal et al., 2010, Carrillo et al., 2010, Hillebrand et al., 2010, Morimoto et al., 2010, Yang et al., 2010, Bostrom et al., 2009, Hansen et al., 2009, Lee et al., 2009, Lu et al., 2009, Pradeep et al., 2009, Ruedi and Hughes, 2009, Wong et al., 2009, Lee and Han, 2008, Riddle et al., 2008, Baker et al., 2007, Harrisingh et al., 2007, Johansson et al., 2007, Kazama et al., 2007, Shakiryanova et al., 2007, Ashraf et al., 2006, Ashraf et al., 2006, Barbee et al., 2006, Hodge et al., 2006, Mehren and Griffith, 2006, van der Plas et al., 2006, White-Grindley and Si, 2006, Dunn and Mercier, 2005, Marques, 2005, Mehren and Griffith, 2004, Morimoto-Tanifuji et al., 2004, Sun et al., 2004, Broughton et al., 2003, Dubnau et al., 2003, Hall, 2003, Kazama et al., 2003, Lu et al., 2003, Park et al., 2002, Yao and Wu, 2001, GuptaRoy et al., 2000, Long and Griffith, 2000, Koh et al., 1999)

CaMKii

(Hope et al., 2020)

Calcium/calmodulin-dependent protein kinase

(Morley and Montgomery, 2001)

Cam

CamK-II

(Evans et al., 2014)

CamKII

(Xu et al., 2020, Sanguanini and Cattaneo, 2018, Pek et al., 2015, Lee et al., 2009, Haghighi et al., 2002, Dubnau and Tully, 1998)

CamKIIα

Camkii

(Schwartz et al., 2009)

DCK

(Cho, 1994.10.30)

calcium/calmodulin-dependent protein kinase II

(Griffith, 1993.11.23, Griffith, 1993.11.23, Griffith, 1993.11.23, Griffith, 1993.11.23, Griffith, 1993.11.23)

camKII

(Loedige et al., 2015, Solano et al., 2003, Locke et al., 2000)

camkII

(Wang et al., 2014)

dCAMKII

(Lin et al., 2008)

dCaMKII

(Schwartz et al., 2016, Lin et al., 2008, Takamatsu et al., 2003, Takamatsu et al., 2002, Iourgenko and Levin, 2000)

l(4)102EFb

l(4)16

(Hochman, 1976, Hochman, 1974, Hochman, 1971)

l(4)ar

Name Synonyms

Ca2+ calmodulin-dependent kinase II

(Sadanandappa et al., 2013)

Ca2+/calmodulin-dependent protein kinase II

(Sudhakaran et al., 2014)

Ca2+-calmodulin-dependent protein kinase II

(Cannon and Bodmer, 2016)

Ca2+/Calmodulin-dependent protein kinase II

(Lee and Han, 2008)

Ca2+/calmodulin-dependent protein kinase II

(Talamillo et al., 2008, Yao and Wu, 2001)

CaM kinase

(Griffith and Greenspan, 1993, Griffith et al., 1993)

CaM kinase II

(Pu et al., 2006, Xu et al., 1998, Greenspan et al., 1995, Takamatsu et al., 1994)

CaM-kinase-II

(Hall, 2003)

Calcium/calmodulin-dependent protein kinase

(Khanna et al., 2010)

Calcium/calmodulin-dependent protein kinase II

(Kadas et al., 2012, Cammarato et al., 2011, Kazama et al., 2007)

Calcium/calmodulin-dependent protein kinase ii

(Wang et al., 2016)

Calmodulin kinase II

(Shakiryanova et al., 2007)

calcium/ calmodulin-dependent protein kinase II

(GuptaRoy et al., 2000)

calcium/calmodulin-dependent protein kinase II

(Bostrom et al., 2009, Morimoto-Tanifuji et al., 2004, Broughton et al., 2003, Kazama et al., 2003, Takamatsu et al., 2003)

calcium/calmodulin-dependent protein kinase type II

(Hosamani et al., 2016)

calmodulin-dependent kinase

(Harris and Lim, 2001)

calmodulin-dependent protein kinase II

(Harrisingh et al., 2007)

lethal (4) 102EFb

Secondary FlyBase IDs

FBgn0004624
FBgn0004537

Datasets (8)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (8)

Result

Result Type

Title

scRNAseq_2020_Cattenoz_NI_seq_clustering

cell clustering analysis

Clustering analysis of hemocytes from non-infested third instar larvae

scRNAseq_2020_Cattenoz_WI_seq_clustering

cell clustering analysis

Clustering analysis of hemocytes from wasp-infested third instar larvae

scRNAseq_2020_Cho_NI72LG_seq_clustering

cell clustering analysis

Clustering analysis of lymph gland cells from non-infested larvae at 72 h after egg-laying

scRNAseq_2020_Cho_NI96LG_seq_clustering

cell clustering analysis

Clustering analysis of lymph gland cells from non-infested larvae at 96 h after egg-laying

scRNAseq_2020_Cho_NI120LG_seq_clustering

cell clustering analysis

Clustering analysis of lymph gland cells from non-infested larvae at 120 h after egg-laying

scRNAseq_2020_Cho_WI96LG_seq_clustering

cell clustering analysis

Clustering analysis of lymph gland cells from wasp-infested larvae at 96 h after egg-laying

scRNAseq_2020_Cho_NI96HL_seq_clustering

cell clustering analysis

Clustering analysis of circulating hemocytes from non-infested larvae at 96 h after egg-laying

scRNAseq_2020_Cho_NI120HL_seq_clustering

cell clustering analysis

Clustering analysis of circulating hemocytes from non-infested larvae at 120 h after egg-laying

References (299)