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Gene Dmel\btsz

General Information
Symbol	Dmel\btsz	Species	D. melanogaster
Name	bitesize	Annotation symbol	CG44012
Feature type	protein_coding_gene	FlyBase ID	FBgn0264754
Gene Model Status	Current	Stock availability	26 publicly available
Also Known As	l(3)10418, CG7343
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	88D5-88D5	Sequence location	3R:10,629,814..10,701,210 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene bitesize is referred to in FlyBase by the symbol Dmel\btsz (CG44012, FBgn0264754). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: transporter activity. There is experimental evidence that it is involved in the biological process: morphogenesis of embryonic epithelium; establishment of planar polarity of embryonic epithelium; positive regulation of cell size; apical junction assembly; gastrulation involving germ band extension; actin filament organization; positive regulation of multicellular organism growth. 40 alleles are reported. The phenotypes of these alleles are annotated with: eye; macrochaeta; mesothoracic tergum; tormogen cell; wing; ommatidium. It has 9 annotated transcripts and 9 annotated polypeptides. Protein features are: C2 calcium-dependent membrane targeting; C2 calcium/lipid-binding domain, CaLB; C2 membrane targeting protein; Synaptotagmin. Gene sequence location is 3R:10629814..10701210.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 88D5-88D5   Limits computationally determined from genome sequence between P{EP}CG33967EP666 and P{lacW}Hsc70-4L3929
Experimentally Determined Cytological Location
Cytogenetic map Notes References 88D5-88D6   (determined by in situ hybridisation)   (Spradling et al., 1999) 88D5-88D6   (determined by in situ hybridisation)   (BDGP Project Members, 1994-1999)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\btsz for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Low-frequency RNA-Seq exon junction(s) not annotated. Gene model reviewed during 5.47 Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) btsz-RB FBtr0334285  NM_001014625   7376   1102 btsz-RC FBtr0334286  NM_001014624   8811   2645 btsz-RD FBtr0334287  NM_001014623   5606   1517 btsz-RE FBtr0334288  NM_001104324   3037   708 btsz-RF FBtr0334289  NM_001144583   2713   600 btsz-RG FBtr0334290  NM_001275653   8309   1567 btsz-RH FBtr0334291  NM_001144584   7481   1137 btsz-RI FBtr0334292  NM_001260180   14849   3734 btsz-RJ FBtr0334293  NM_001014622   8282   1567
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein btsz-PB   FBpp0306400   121.5   1102   9.28     NP_001014625   AAX52953 btsz-PC   FBpp0306401   285.8   2645   5.28     NP_001014624   AAX52954 btsz-PD   FBpp0306402   164.9   1517   5.50     NP_001014623   AAX52955 btsz-PE   FBpp0306403   80.2   708   10.01     NP_001097794   ABW08676 btsz-PF   FBpp0306404   67.7   600   10.32     NP_001138055   ACL83513 btsz-PG   FBpp0306405   171.0   1567   8.99     NP_001262582   AGB95963 btsz-PH   FBpp0306406   125.5   1137   9.40     NP_001138056   ACL83514 btsz-PI   FBpp0306407   405.1   3734   5.78     NP_001247109   AFH06427 btsz-PJ   FBpp0306408   171.0   1567   8.99     NP_001014622   AAX52952
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Synaptotagmin (IPR001565) C2 membrane targeting protein (IPR018029) C2 calcium/lipid-binding domain, CaLB (IPR008973) C2 calcium-dependent membrane targeting (IPR000008)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA699078   AE014297 AAX52952   AE014297 AAX52953   AE014297 AAX52954   AE014297 AAX52955   AE014297 ABW08676   AE014297 ACL83513   AE014297 ACL83514   AE014297 AFH06427   AE014297 AGB95963   AI113358   AI259248   AI387616   AQ026231   AQ073020   AY118748 AAM50608   AY229969 AAP04480   AY229970 AAP04481   AY229971 AAP04482   BI616850   BI627125   BT003616   BT024249   BT025937   BX008809   BX012118   BX059727   BX064714   BX067805   CK131412   CK661856   CL525886   CO177333   CO187427   CO190481   CO266465   CO268582   CO274373   CO313466   CO324597   CO326887   CO338971   CO342239   CO344248   CO344616   CZ469483   CZ471364   CZ476509   DQ138686 ABA86292   EC058008   EC065949   EC080492   EC083026   EC194506   EC202703   EC221937   EC223263   EC223626   EC235282   EC243012   EC243945   EC256279   EC259179   EC259681   EC260157   EL879208   EL879562   EL884368   EL884481
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q8MSJ8 Q6XK20 Q2XYH6 Q59DW9 Q9VFF5 Q59DX2 Q6XK18 B7Z0K1 A8JR10 B7Z0K2 Q6XK19
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 4 -- 6   dorsal ectoderm anlage   (Fisher et al., 2012) Comment:anlage in statu nascendi mesoderm anlage   (Fisher et al., 2012) Comment:anlage in statu nascendi organism | ubiquitous   (Fisher et al., 2012) posterior ectoderm anlage   (Fisher et al., 2012) Comment:anlage in statu nascendi embryonic stage 7 -- 8   dorsal ectoderm   (Fisher et al., 2012) organism | faint & ubiquitous   (Fisher et al., 2012) posterior endoderm   (Fisher et al., 2012) embryonic stage 9 -- 10   dorsal ectoderm   (Fisher et al., 2012) inclusive hindgut primordium   (Fisher et al., 2012) organism | faint & ubiquitous   (Fisher et al., 2012) posterior endoderm   (Fisher et al., 2012) salivary gland body primordium   (Fisher et al., 2012) Comment:reported as salivary gland body specific anlage embryonic stage 11 -- 12   dorsal epidermis primordium   (Fisher et al., 2012) foregut primordium   (Fisher et al., 2012) hindgut proper primordium   (Fisher et al., 2012) organism | faint & ubiquitous   (Fisher et al., 2012) salivary gland body primordium   (Fisher et al., 2012) Comment:reported as salivary gland primordium stomatogastric nervous system primordium   (Fisher et al., 2012) embryonic stage 13 -- 16   atrium   (Fisher et al., 2012) embryonic dorsal epidermis   (Fisher et al., 2012) embryonic epipharynx   (Fisher et al., 2012) embryonic foregut   (Fisher et al., 2012) embryonic head epidermis   (Fisher et al., 2012) embryonic hindgut   (Fisher et al., 2012) embryonic hypopharynx   (Fisher et al., 2012) embryonic main segment of Malpighian tubule   (Fisher et al., 2012) embryonic Malpighian tubule   (Fisher et al., 2012) embryonic stomatogastric nervous system   (Fisher et al., 2012) embryonic ventral epidermis   (Fisher et al., 2012) embryonic/larval salivary gland   (Fisher et al., 2012)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 5 of adulthood & male -- day 7 of adulthood & male   spermatozoon   (Wasbrough et al., 2010)
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    12 central nervous system, larvae L3    6 central nervous system, pupae P8    6 head, virgin 1-day female    10 head, virgin 4-day female    6 head, virgin 20-day female    6 head, mated 1-day female    8 head, mated 4-day female    6 head, mated 20-day female    5 head, mated 1-day male    13 head, mated 4-day male    9 head, mated 20-day male    9 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    17 digestive system, larvae L3 wandering    7 digestive system, 1-day adult    6 digestive system, 4-day adult    7 digestive system, 20-day adult    6 fat body, larvae L3 wandering    1 fat body, white prepupae    2 fat body, pupae P8    8 carcass, larvae L3 wandering    15 carcass, 1-day adult    8 carcass, 4-day adult    5 carcass, 20-day adult    4 ovary, virgin 4-day female    4 ovary, mated 4-day female    3 testis, mated 4-day male    2 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    12 central nervous system, larvae L3    6 central nervous system, pupae P8    6 head, virgin 1-day female    10 head, virgin 4-day female    6 head, virgin 20-day female    6 head, mated 1-day female    8 head, mated 4-day female    6 head, mated 20-day female    5 head, mated 1-day male    13 head, mated 4-day male    9 head, mated 20-day male    9 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    17 digestive system, larvae L3 wandering    7 digestive system, 1-day adult    6 digestive system, 4-day adult    7 digestive system, 20-day adult    6 fat body, larvae L3 wandering    1 fat body, white prepupae    2 fat body, pupae P8    8 carcass, larvae L3 wandering    15 carcass, 1-day adult    8 carcass, 4-day adult    5 carcass, 20-day adult    4 ovary, virgin 4-day female    4 ovary, mated 4-day female    3 testis, mated 4-day male    2 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    12 central nervous system, larvae L3    6 central nervous system, pupae P8    6 head, virgin 1-day female    10 head, virgin 4-day female    6 head, virgin 20-day female    6 head, mated 1-day female    8 head, mated 4-day female    6 head, mated 20-day female    5 head, mated 1-day male    13 head, mated 4-day male    9 head, mated 20-day male    9 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    17 digestive system, larvae L3 wandering    7 digestive system, 1-day adult    6 digestive system, 4-day adult    7 digestive system, 20-day adult    6 fat body, larvae L3 wandering    1 fat body, white prepupae    2 fat body, pupae P8    8 carcass, larvae L3 wandering    15 carcass, 1-day adult    8 carcass, 4-day adult    5 carcass, 20-day adult    4 ovary, virgin 4-day female    4 ovary, mated 4-day female    3 testis, mated 4-day male    2 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    12 central nervous system, larvae L3    6 central nervous system, pupae P8    6 head, virgin 1-day female    10 head, virgin 4-day female    6 head, virgin 20-day female    6 head, mated 1-day female    8 head, mated 4-day female    6 head, mated 20-day female    5 head, mated 1-day male    13 head, mated 4-day male    9 head, mated 20-day male    9 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    17 digestive system, larvae L3 wandering    7 digestive system, 1-day adult    6 digestive system, 4-day adult    7 digestive system, 20-day adult    6 fat body, larvae L3 wandering    1 fat body, white prepupae    2 fat body, pupae P8    8 carcass, larvae L3 wandering    15 carcass, 1-day adult    8 carcass, 4-day adult    5 carcass, 20-day adult    4 ovary, virgin 4-day female    4 ovary, mated 4-day female    3 testis, mated 4-day male    2 accessory gland, mated 4-day male    2 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    12 central nervous system, larvae L3    6 central nervous system, pupae P8    6 head, virgin 1-day female    10 head, virgin 4-day female    6 head, virgin 20-day female    6 head, mated 1-day female    8 head, mated 4-day female    6 head, mated 20-day female    5 head, mated 1-day male    13 head, mated 4-day male    9 head, mated 20-day male    9 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    17 digestive system, larvae L3 wandering    7 digestive system, 1-day adult    6 digestive system, 4-day adult    7 digestive system, 20-day adult    6 fat body, larvae L3 wandering    1 fat body, white prepupae    2 fat body, pupae P8    8 carcass, larvae L3 wandering    15 carcass, 1-day adult    8 carcass, 4-day adult    5 carcass, 20-day adult    4 ovary, virgin 4-day female    4 ovary, mated 4-day female    3 testis, mated 4-day male    2 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    12 central nervous system, larvae L3    6 central nervous system, pupae P8    6 head, virgin 1-day female    10 head, virgin 4-day female    6 head, virgin 20-day female    6 head, mated 1-day female    8 head, mated 4-day female    6 head, mated 20-day female    5 head, mated 1-day male    13 head, mated 4-day male    9 head, mated 20-day male    9 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    17 digestive system, larvae L3 wandering    7 digestive system, 1-day adult    6 digestive system, 4-day adult    7 digestive system, 20-day adult    6 fat body, larvae L3 wandering    1 fat body, white prepupae    2 fat body, pupae P8    8 carcass, larvae L3 wandering    15 carcass, 1-day adult    8 carcass, 4-day adult    5 carcass, 20-day adult    4 ovary, virgin 4-day female    4 ovary, mated 4-day female    3 testis, mated 4-day male    2 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    12 central nervous system, larvae L3    6 central nervous system, pupae P8    6 head, virgin 1-day female    10 head, virgin 4-day female    6 head, virgin 20-day female    6 head, mated 1-day female    8 head, mated 4-day female    6 head, mated 20-day female    5 head, mated 1-day male    13 head, mated 4-day male    9 head, mated 20-day male    9 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    17 digestive system, larvae L3 wandering    7 digestive system, 1-day adult    6 digestive system, 4-day adult    7 digestive system, 20-day adult    6 fat body, larvae L3 wandering    1 fat body, white prepupae    2 fat body, pupae P8    8 carcass, larvae L3 wandering    15 carcass, 1-day adult    8 carcass, 4-day adult    5 carcass, 20-day adult    4 ovary, virgin 4-day female    4 ovary, mated 4-day female    3 testis, mated 4-day male    2 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    12 central nervous system, larvae L3    6 central nervous system, pupae P8    6 head, virgin 1-day female    10 head, virgin 4-day female    6 head, virgin 20-day female    6 head, mated 1-day female    8 head, mated 4-day female    6 head, mated 20-day female    5 head, mated 1-day male    13 head, mated 4-day male    9 head, mated 20-day male    9 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    17 digestive system, larvae L3 wandering    7 digestive system, 1-day adult    6 digestive system, 4-day adult    7 digestive system, 20-day adult    6 fat body, larvae L3 wandering    1 fat body, white prepupae    2 fat body, pupae P8    8 carcass, larvae L3 wandering    15 carcass, 1-day adult    8 carcass, 4-day adult    5 carcass, 20-day adult    4 ovary, virgin 4-day female    4 ovary, mated 4-day female    3 testis, mated 4-day male    2 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    3 embryo 02-04hr    45 embryo 04-06hr    25 embryo 06-08hr    20 embryo 08-10hr    20 embryo 10-12hr    16 embryo 12-14hr    16 embryo 14-16hr    15 embryo 16-18hr    12 embryo 18-20hr    12 embryo 20-22hr    9 embryo 22-24hr    9 larva L1    9 larva L2    10 larva L3 12hr old    8 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    10 larva L3 puffstage 7-9    11 white prepupae new    14 white prepupae 12hr    20 white prepupae 24hr    23 pupae 2d postWPP    18 pupae 3d postWPP    13 pupae 4d postWPP    8 adult male 01day    11 adult male 05day    8 adult male 30day    8 adult female 01day    9 adult female 05day    5 adult female 30day    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    3 embryo 02-04hr  (45) embryo 04-06hr    25 embryo 06-08hr    20 embryo 08-10hr    20 embryo 10-12hr    16 embryo 12-14hr    16 embryo 14-16hr    15 embryo 16-18hr    12 embryo 18-20hr    12 embryo 20-22hr    9 embryo 22-24hr    9 larva L1    9 larva L2    10 larva L3 12hr old    8 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    10 larva L3 puffstage 7-9    11 white prepupae new    14 white prepupae 12hr    20 white prepupae 24hr    23 pupae 2d postWPP    18 pupae 3d postWPP    13 pupae 4d postWPP    8 adult male 01day    11 adult male 05day    8 adult male 30day    8 adult female 01day    9 adult female 05day    5 adult female 30day    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    3 embryo 02-04hr    45 embryo 04-06hr    25 embryo 06-08hr    20 embryo 08-10hr    20 embryo 10-12hr    16 embryo 12-14hr    16 embryo 14-16hr    15 embryo 16-18hr    12 embryo 18-20hr    12 embryo 20-22hr    9 embryo 22-24hr    9 larva L1    9 larva L2    10 larva L3 12hr old    8 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    10 larva L3 puffstage 7-9    11 white prepupae new    14 white prepupae 12hr    20 white prepupae 24hr    23 pupae 2d postWPP    18 pupae 3d postWPP    13 pupae 4d postWPP    8 adult male 01day    11 adult male 05day    8 adult male 30day    8 adult female 01day    9 adult female 05day    5 adult female 30day    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    3 embryo 02-04hr    45 embryo 04-06hr    25 embryo 06-08hr    20 embryo 08-10hr    20 embryo 10-12hr    16 embryo 12-14hr    16 embryo 14-16hr    15 embryo 16-18hr    12 embryo 18-20hr    12 embryo 20-22hr    9 embryo 22-24hr    9 larva L1    9 larva L2    10 larva L3 12hr old    8 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    10 larva L3 puffstage 7-9    11 white prepupae new    14 white prepupae 12hr    20 white prepupae 24hr    23 pupae 2d postWPP    18 pupae 3d postWPP    13 pupae 4d postWPP    8 adult male 01day    11 adult male 05day    8 adult male 30day    8 adult female 01day    9 adult female 05day    5 adult female 30day    5 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    3 embryo 02-04hr    45 embryo 04-06hr    25 embryo 06-08hr    20 embryo 08-10hr    20 embryo 10-12hr    16 embryo 12-14hr    16 embryo 14-16hr    15 embryo 16-18hr    12 embryo 18-20hr    12 embryo 20-22hr    9 embryo 22-24hr    9 larva L1    9 larva L2    10 larva L3 12hr old    8 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    10 larva L3 puffstage 7-9    11 white prepupae new    14 white prepupae 12hr    20 white prepupae 24hr    23 pupae 2d postWPP    18 pupae 3d postWPP    13 pupae 4d postWPP    8 adult male 01day    11 adult male 05day    8 adult male 30day    8 adult female 01day    9 adult female 05day    5 adult female 30day    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    3 embryo 02-04hr  (45) embryo 04-06hr    25 embryo 06-08hr    20 embryo 08-10hr    20 embryo 10-12hr    16 embryo 12-14hr    16 embryo 14-16hr    15 embryo 16-18hr    12 embryo 18-20hr    12 embryo 20-22hr    9 embryo 22-24hr    9 larva L1    9 larva L2    10 larva L3 12hr old    8 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    10 larva L3 puffstage 7-9    11 white prepupae new    14 white prepupae 12hr    20 white prepupae 24hr    23 pupae 2d postWPP    18 pupae 3d postWPP    13 pupae 4d postWPP    8 adult male 01day    11 adult male 05day    8 adult male 30day    8 adult female 01day    9 adult female 05day    5 adult female 30day    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    3 embryo 02-04hr    45 embryo 04-06hr    25 embryo 06-08hr    20 embryo 08-10hr    20 embryo 10-12hr    16 embryo 12-14hr    16 embryo 14-16hr    15 embryo 16-18hr    12 embryo 18-20hr    12 embryo 20-22hr    9 embryo 22-24hr    9 larva L1    9 larva L2    10 larva L3 12hr old    8 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    10 larva L3 puffstage 7-9    11 white prepupae new    14 white prepupae 12hr    20 white prepupae 24hr    23 pupae 2d postWPP    18 pupae 3d postWPP    13 pupae 4d postWPP    8 adult male 01day    11 adult male 05day    8 adult male 30day    8 adult female 01day    9 adult female 05day    5 adult female 30day    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    3 embryo 02-04hr    45 embryo 04-06hr    25 embryo 06-08hr    20 embryo 08-10hr    20 embryo 10-12hr    16 embryo 12-14hr    16 embryo 14-16hr    15 embryo 16-18hr    12 embryo 18-20hr    12 embryo 20-22hr    9 embryo 22-24hr    9 larva L1    9 larva L2    10 larva L3 12hr old    8 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    10 larva L3 puffstage 7-9    11 white prepupae new    14 white prepupae 12hr    20 white prepupae 24hr    23 pupae 2d postWPP    18 pupae 3d postWPP    13 pupae 4d postWPP    8 adult male 01day    11 adult male 05day    8 adult male 30day    8 adult female 01day    9 adult female 05day    5 adult female 30day    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    6 embryonic 1182-4H    0 embryonic GM2    4 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    7 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    1 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    4 ovary fGS/OSS    0 ovary OSC    2 ovary OSS    1 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    6 embryonic 1182-4H    0 embryonic GM2    4 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    7 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    1 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    4 ovary fGS/OSS    0 ovary OSC    2 ovary OSS    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    6 embryonic 1182-4H    0 embryonic GM2    4 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    7 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    1 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    4 ovary fGS/OSS    0 ovary OSC    2 ovary OSS    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    6 embryonic 1182-4H    0 embryonic GM2    4 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    7 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    1 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    4 ovary fGS/OSS    0 ovary OSC    2 ovary OSS    1 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    6 embryonic 1182-4H    0 embryonic GM2    4 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    7 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    1 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    4 ovary fGS/OSS    0 ovary OSC    2 ovary OSS    1 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    6 embryonic 1182-4H    0 embryonic GM2    4 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    7 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    1 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    4 ovary fGS/OSS    0 ovary OSC    2 ovary OSS    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    6 embryonic 1182-4H    0 embryonic GM2    4 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    7 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    1 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    4 ovary fGS/OSS    0 ovary OSC    2 ovary OSS    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    6 embryonic 1182-4H    0 embryonic GM2    4 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    7 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    1 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    4 ovary fGS/OSS    0 ovary OSC    2 ovary OSS    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    5 cold shock, 4-day adult    5 heat shock, 4-day adult    5 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    4 Cadmium 100 mM 48 hrs, 4-day adult    4 Copper 0.5 mM 12 hrs, larvae L3    4 Copper 15 mM 48 hrs, 4-day adult    3 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    4 Ethanol 2.5% 3 hrs, larvae L3    5 Ethanol 5% 3 hrs, larvae L3    3 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    3 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    5 Paraquat 10 mM 48 hrs, 4-day adult    8 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    4 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    5 cold shock, 4-day adult    5 heat shock, 4-day adult    5 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    4 Cadmium 100 mM 48 hrs, 4-day adult    4 Copper 0.5 mM 12 hrs, larvae L3    4 Copper 15 mM 48 hrs, 4-day adult    3 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    4 Ethanol 2.5% 3 hrs, larvae L3    5 Ethanol 5% 3 hrs, larvae L3    3 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    3 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    5 Paraquat 10 mM 48 hrs, 4-day adult    8 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    5 cold shock, 4-day adult    5 heat shock, 4-day adult    5 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    4 Cadmium 100 mM 48 hrs, 4-day adult    4 Copper 0.5 mM 12 hrs, larvae L3    4 Copper 15 mM 48 hrs, 4-day adult    3 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    4 Ethanol 2.5% 3 hrs, larvae L3    5 Ethanol 5% 3 hrs, larvae L3    3 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    3 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    5 Paraquat 10 mM 48 hrs, 4-day adult    8 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    5 cold shock, 4-day adult    5 heat shock, 4-day adult    5 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    4 Cadmium 100 mM 48 hrs, 4-day adult    4 Copper 0.5 mM 12 hrs, larvae L3    4 Copper 15 mM 48 hrs, 4-day adult    3 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    4 Ethanol 2.5% 3 hrs, larvae L3    5 Ethanol 5% 3 hrs, larvae L3    3 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    3 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    5 Paraquat 10 mM 48 hrs, 4-day adult    8 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    4 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    5 cold shock, 4-day adult    5 heat shock, 4-day adult    5 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    4 Cadmium 100 mM 48 hrs, 4-day adult    4 Copper 0.5 mM 12 hrs, larvae L3    4 Copper 15 mM 48 hrs, 4-day adult    3 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    4 Ethanol 2.5% 3 hrs, larvae L3    5 Ethanol 5% 3 hrs, larvae L3    3 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    3 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    5 Paraquat 10 mM 48 hrs, 4-day adult    8 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    4 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    5 cold shock, 4-day adult    5 heat shock, 4-day adult    5 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    4 Cadmium 100 mM 48 hrs, 4-day adult    4 Copper 0.5 mM 12 hrs, larvae L3    4 Copper 15 mM 48 hrs, 4-day adult    3 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    4 Ethanol 2.5% 3 hrs, larvae L3    5 Ethanol 5% 3 hrs, larvae L3    3 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    3 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    5 Paraquat 10 mM 48 hrs, 4-day adult    8 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    5 cold shock, 4-day adult    5 heat shock, 4-day adult    5 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    4 Cadmium 100 mM 48 hrs, 4-day adult    4 Copper 0.5 mM 12 hrs, larvae L3    4 Copper 15 mM 48 hrs, 4-day adult    3 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    4 Ethanol 2.5% 3 hrs, larvae L3    5 Ethanol 5% 3 hrs, larvae L3    3 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    3 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    5 Paraquat 10 mM 48 hrs, 4-day adult    8 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    5 cold shock, 4-day adult    5 heat shock, 4-day adult    5 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    4 Cadmium 100 mM 48 hrs, 4-day adult    4 Copper 0.5 mM 12 hrs, larvae L3    4 Copper 15 mM 48 hrs, 4-day adult    3 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    4 Ethanol 2.5% 3 hrs, larvae L3    5 Ethanol 5% 3 hrs, larvae L3    3 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    3 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    5 Paraquat 10 mM 48 hrs, 4-day adult    8 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_11
External Data & Images
Linkouts	BDGP expression data • LP02621
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal btszJ5-2 lethal | germline clone btszJ5-2 lethal | pupal stage, with Scer\GAL4pnr-MD237 btszGD2989 lethal | recessive btsz10418 partially lethal - majority die btsz10418 partially lethal - majority die | larval stage | recessive btszJ5-2 partially lethal - majority die | recessive btsz10418 viable btsz10418 btszEY03603 viable, with Scer\GAL4[-]: btszEP3567 viable, with Scer\GAL4pnr-MD237 btszGD10224 btszGD12208 Sterility Allele fertile btsz10418 btszEY03603 semi-fertile | recessive btszunspecified Other Phenotypes Allele body color defective, with Scer\GAL4pnr-MD237 btszGD2989 body color defective | recessive btszunspecified decreased cell number | adult stage | recessive btszJ5-2 decreased cell size | adult stage | recessive btszJ5-2 small body | adult stage | recessive btszJ5-2 visible, with Scer\GAL4pnr-MD237 btszGD10224 Phenotype manifest in Allele eye btszunspecified macrochaeta btszunspecified mesothoracic tergum, with Scer\GAL4pnr-MD237 btszGD10224 btszGD2989 ommatidium btszunspecified tormogen cell, with Scer\GAL4pnr-MD237 btszGD10224 wing btszunspecified
Classical Alleles ( 19 )
For All Classical Alleles Show
Allele of btsz Class Mutagen Stocks Known lesion btsz10418 P-element activity 1 Yes btszd00072 P-element activity 1 -- btszd08989 P-element activity 1 -- btsze02796 1 -- btszEP3567 P-element activity 1 Yes btszEY02982 1 -- btszEY03603 P-element activity 1 -- btszf02808 1 -- btszJ5-2 P-element activity 1 Yes btszK13-4 P-element activity 1 Yes btszMI01714 1 -- btszMI05023 1 -- btszMI07695 1 -- btszNP5412 1 -- btsz5-HA-2183 0 -- btszc04745 piggyBac transposase 0 -- btszDG09205 0 -- btszEY15736 0 -- btszunspecified 0 --
Alleles Carried on Transgenic Constructs ( 21 )
For All Alleles Carried on Transgenic Constructs Show
Allele of btsz Class Mutagen Stocks Known lesion btszGD10224 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes btszGD2989 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes btsz1.gl.Scer\UAS in vitro construct - regulatory fusion 1 Yes btsz2.gl.Scer\UAS.T:PV\Pym in vitro construct - regulatory fusion in vitro construct - coding region fusion 1 Yes btsz2.gl.Scer\UAS in vitro construct - regulatory fusion 1 Yes btsz3.Scer\UAS in vitro construct - regulatory fusion 1 Yes btszBLR.Scer\UAS.T:Avic\GFP-EGFP in vitro construct - regulatory fusion 1 Yes btszHMS02146 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes btszKK111279 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes btszKK112184 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes btsz2.gl.Scer\UAS.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes btsz2.Δ3'UTR.gl.Scer\UAS in vitro construct - regulatory fusion 0 Yes btsz3.Δ3'UTR.Scer\UAS in vitro construct - regulatory fusion 0 Yes btsz3.ΔC2.Scer\UAS in vitro construct - regulatory fusion in vitro construct 0 Yes btsz3.ΔCT.Scer\UAS in vitro construct - regulatory fusion 0 Yes btszC2.gl.Scer\UAS in vitro construct - regulatory fusion 0 Yes btszC2AB.Scer\UAS.T:Ivir\HA1 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes btszCT.Scer\UAS.T:Avic\GFP-EGFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes btszGD12208 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes btszNIG.7343R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes btszΔC2AB.Scer\UAS.T:Ivir\HA1 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3R)Exel6172 (Ryder, 2004.4.26) Df(3R)Exel6275 (Ryder, 2004.4.26) Df(3R)Exel8160 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD10224} NA P{GUS-btsz.1} NA P{GUS-btsz.2} NA P{GUS-btsz.2myc} NA P{GUS-btsz.2poly} NA P{GUS-btsz.2Δ3'UTR} NA P{GUS-btsz.3ΔC2} NA P{KK112184} NA P{NIG.7343R} NA P{TRiP.HMS02146} NA P{UAS-btsz.3} NA P{UAS-btsz.3Δ3'UTR} NA P{UAS-btsz.3ΔC2} NA P{UAS-btsz.3ΔCT} NA P{UAS-btsz.CT} NA P{UAS-btsz.ΔC2AB-HA} NA P{UAS-C2AB-HA} NA P{UAS-GFP.BLR} NA characterization construct P{GD12208} NA
Insertions
	Type of insertions Name Expression data insertion of enhancer trap P{PZ}btsz10418 No insertion of mobile activating element P{EP}btszEP3567 NA P{EPgy2}btszEY02982 NA P{EPgy2}btszEY03603 NA P{EPgy2}btszEY15736 NA P{XP}btszd00072 NA P{XP}btszd08989 NA miscellaneous insertions Mi{MIC}btszMI01714 NA Mi{MIC}btszMI05023 NA Mi{MIC}btszMI07695 NA P{RS5}btsz5-HA-2183 NA P{wHy}btszDG09205 NA PBac{PB}btszc04745 NA PBac{RB}btsze02796 NA PBac{WH}btszf02808 NA insertion of enhancer trap binary system P{GawB}btszNP5412 No
Gene Ontology: Function, Process & Cellular Component ( 11 unique terms )
Terms Based on Experimental Evidence ( 7 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
actin filament organization inferred from mutant phenotype (Pilot et al., 2006) apical junction assembly inferred from mutant phenotype (Pilot et al., 2006) establishment of planar polarity of embryonic epithelium inferred from mutant phenotype (Pilot et al., 2006) gastrulation involving germ band extension inferred from mutant phenotype (Pilot et al., 2006) morphogenesis of embryonic epithelium inferred from mutant phenotype (Pilot et al., 2006) positive regulation of cell size inferred from mutant phenotype (Serano and Rubin, 2003) positive regulation of multicellular organism growth inferred from mutant phenotype (Serano and Rubin, 2003)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 4 terms )
Molecular Function
CV term Evidence References
transporter activity inferred from sequence or structural similarity with UniProtKB:Q96C24 (FlyBase, 1992-)
Biological Process
CV term Evidence References
synaptic vesicle transport inferred from sequence or structural similarity with UniProtKB:Q96C24 (FlyBase, 1992-)
Cellular Component
CV term Evidence References
membrane inferred from sequence or structural similarity with UniProtKB:Q96C24 (FlyBase, 1992-) synaptic vesicle inferred from electronic annotation with InterPro:IPR001565 (FlyBase Curators et al., 2004-)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions btsz allele Gene References
External Data
Linkouts
Orthologs
OrthoDB Orthologs (52) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG62FT2V, EOG6FR1CK Dipteran inclusive ortholog search EOG6F4SK2 Insect inclusive ortholog search EOG64F55G Arthropod inclusive ortholog search EOG6ZGMTN Metazoa inclusive ortholog search EOG6HJ1VQ
Orthologs in Drosophila Species (EOG62FT2V, EOG6FR1CK)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\tay     Drosophila melanogaster fruit fly  Dmel\btsz     Drosophila simulans   Dsim\GD20399 Y Y Drosophila sechellia   Dsec\GM11543   Y Drosophila sechellia   Dsec\GM25825 Y Y Drosophila sechellia   Dsec\GM25822 Y   Drosophila erecta   Dere\GG22730   Y Drosophila erecta   Dere\GG21056 Y Y Drosophila erecta   Dere\GG21045 Y   Drosophila yakuba   Dyak\GE26427 Y Y Drosophila yakuba   Dyak\GE26426 Y   Drosophila ananassae   Dana\GF18128 Y Y Drosophila ananassae   Dana\GF18127 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA26691 Y Y Drosophila pseudoobscura pseudoobscura   Dpse\GA14451 Y   Drosophila persimilis   Dper\GL23666 Y   Drosophila willistoni   Dwil\GK13835 Y Y Drosophila willistoni   Dwil\GK13833 Y   Drosophila virilis   Dvir\GJ22970 Y Y Drosophila virilis   Dvir\GJ22969 Y   Drosophila mojavensis   Dmoj\GI10617 Y Y Drosophila mojavensis   Dmoj\GI10615 Y   Drosophila grimshawi   Dgri\GH14085 Y Y Drosophila grimshawi   Dgri\GH14083 Y
Orthologs in non-Drosophila Dipterans (EOG6F4SK2)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL003283 Y Anopheles gambiae Malaria mosquito  Agam\ODD_b Y Anopheles gambiae Malaria mosquito  Agam\AGAP005288 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ001094 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ001093 Y
Orthologs in non-Dipteran Insects (EOG64F55G)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB52856 Y Apis mellifera Western honey bee  Amel\GB52239 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG008906 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH19563 Y Atta cephalotes Leafcutter ant  Acep\ACEP26114 Y Atta cephalotes Leafcutter ant  Acep\ACEP26123 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO20150 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL19023 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL19022 Y Linepithema humile Argentine ant  Lhum\LH24511 Y Linepithema humile Argentine ant  Lhum\LH24512 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB24723 Y Solenopsis invicta Red fire ant  Sinv\SINV15520 Y Solenopsis invicta Red fire ant  Sinv\SINV15477 Y Solenopsis invicta Red fire ant  Sinv\SINV15513 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI001625 Y Bombyx mori Silkmoth  Bmor\BGIBMGA012483 Y Pediculus humanus Human body louse  Phum\PHUM597310 Y Tribolium castaneum Red flour beetle  Tcas\TC001061 Y
Orthologs in non-Insect Arthropods (EOG6ZGMTN)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\JGI_V11_319285 Y Daphnia pulex Water flea  Dpux\JGI_V11_94612 Y Ixodes scapularis Deer tick  Isca\ISCW022158 Y
Orthologs in non-Arthropod Metazoa (EOG6HJ1VQ)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_019745gn Y
Human Orthologs (0)
Gene OMIM HGNC
AAA Orthologs (22) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD20397 Drosophila simulans Dsim\GD20399 Drosophila sechellia Dsec\GM25822 Drosophila sechellia Dsec\GM25825 Drosophila erecta Dere\GG21045 Drosophila erecta Dere\GG21056 Drosophila yakuba Dyak\GE26426 Drosophila yakuba Dyak\GE26427 Drosophila ananassae Dana\GF18127 Drosophila ananassae Dana\GF18128 Drosophila pseudoobscura pseudoobscura Dpse\GA14451 Drosophila pseudoobscura pseudoobscura Dpse\GA26691 Drosophila persimilis Dper\GL23666 Drosophila persimilis Dper\GL23667 Drosophila willistoni Dwil\GK13833 Drosophila willistoni Dwil\GK13835 Drosophila virilis Dvir\GJ22969 Drosophila virilis Dvir\GJ22970 Drosophila mojavensis Dmoj\GI10615 Drosophila mojavensis Dmoj\GI10617 Drosophila grimshawi Dgri\GH14083 Drosophila grimshawi Dgri\GH14085
Stocks & Reagents
Stocks Listed in FlyBase ( 26 )
Bloomington	8658 w1118; P{UAS-btsz.3}3 8661 w1118; P{GUS-btsz.1}2 8659 w1118; P{UAS-GFP.BLR}3 8660 w1118; P{GUS-btsz.2}2/CyO 8662 w1118; P{GUS-btsz.2poly}2
Harvard	- P{XP}btszd00072 - P{XP}btszd08989 - PBac{RB}btsze02796 - PBac{WH}btszf02808
VDRC	v102262 P{KK111279}VIE-260B v102608 P{KK112184}VIE-260B v5878 w1118 P{GD2989}v5878
	More stocks available...
Genomic Clones ( 3 )
	BACR08H11 BACR18C01 BACR48E23 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 43 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GH06647 GH12056 IP13955 IP15871
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH18184 HL07423 LP21618 RH46948 RH68341
Other clones	12491 35597 59322 63804 66510 107241 146067 214353.34 214405.42 214507.37 214565.32 CK01.7A.E11 CK01.34B.A12 CK01.59D.B2 CK01.120C.H11 CK01.170C.D3 EK029227 EK048337 EK053204 EK092024 EK113927 EK146510 EK194330 EK233018 EP00445 EP04918 EP14252 EP18928 EP19614 IP09214 IP09514 IP15671 IP15771 LP02621
RNAi & Array Information
Linkouts
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: btsz CG31306 (FlyBase, 1996-)
Source for database merge of	Source for merge of: btsz CG17304 (FlyBase Genome Annotators, 2012) Source for merge of: l(3)10418 BcDNA:GH06647 (FlyBase, 1996-) Source for merge of: l(3)10418 CG14858 (Levis, 2002.6.25) Source for merge of: l(3)10418 CG18280 (FlyBase Genome Annotators, 2005, FlyBase Genome Annotators, 2002-2003)
Additional comments	Annotations CG33555 and CG17304 merged as CG44012 in release 5.47 of the genome annotation. Merge supported by RNA-seq junction data. (FlyBase Genome Annotators, 2012) Source for identity of btsz CG31306 was sequence comparison (date:030917). (FlyBase Genome Annotators, 2005, FlyBase, 1996-) Annotations CG14858 and CG18280 merged as CG31306 in release 3 of the genome annotation. (FlyBase Genome Annotators, 2002-2003) Source for merge of l(3)10418 BcDNA:GH06647 was a shared cDNA (date:030728). (FlyBase, 1996-)
Other Comments
	Embryos injected with dsRNA made from templates generated with primers directed against this gene show defects in the organisation of the epithelium at the end of cellularisation. Gastrulation is completely arrested as the epithelium no longer elongates along the anteroposterior axis due to the epithelial cells losing their columnar organisation and becoming mesenchymal. (Pilot et al., 2006) dsRNA made from templates generated with primers directed against this gene severely affects gastrulation, resulting in the epithelium failing to extend properly. Defects are either strong or medium; that is, they are visible at the beginning of gastrulation or about 15 minutes later, respectively. The defects are penetrant (80%) and dose dependent. (Pilot et al., 2006)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_001014622 NM_001014623 NM_001014624 NM_001014625 NM_001104324 NM_001144583 NM_001144584 NM_001260180 NM_001275653 RefSeq (Proteins) • NP_001014622 NP_001014623 NP_001014624 NP_001014625 NP_001097794 NP_001138055 NP_001138056 NP_001247109 NP_001262582 DDBJ / EMBL / GenBank • AAF55105 AAM50608 AAP04480 AAP04481 AAP04482 AAX52952 AAX52953 AAX52954 AAX52955 ABA86292 ABW08676 ACL83513 ACL83514 AFH06427 AGB95963 AI113358 AI259248 AQ026231 AQ073020 AY118748 AY229969 AY229970 AY229971 CL525886 CZ469483 CZ471364 CZ476509 DQ138686 Entrez Gene - A searchable database of RefSeq genes. • 41796 3346167 UniProtKB/TrEMBL • A8JR10 B7Z0K1 B7Z0K2 Q2XYH6 Q6XK18 Q6XK19 Q6XK20 Q8MSJ8 Q9VFF5 Q59DW9 Q59DX2
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Synaptotagmin (IPR001565) C2 membrane targeting protein (IPR018029) C2 calcium/lipid-binding domain, CaLB (IPR008973) C2 calcium-dependent membrane targeting (IPR000008) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • LP02621
Linkouts
Synonyms & Secondary IDs ( 13 )
Reported As
Symbol Synonym	BcDNA:GH06647   btsz (Cavey et al., 2008, Maybeck and Röper, 2009, Liang et al., 2008, Wasbrough et al., 2010, Japanese National Institute of Genetics, 2012.5.21) Btsz (Pilot et al., 2006, Pilot, 2006, Halbleib and Nelson, 2006) CG7343 (Jasper et al., 2002, Giot et al., 2003, Pilot et al., 2006) CG14858 (Pilot et al., 2006) CG17304 (Keleman et al., 2009.8.5) CG18280   CG31306   CG33555 (Keleman et al., 2009.8.5) CG44012 (FlyBase Genome Annotators, 2012, Ni et al., 2010.12.1) l(3)10418 (Berkeley Drosophila Genome Project, 1993.6.1, Levis, 2002.6.25, Spradling et al., 1999, BDGP Project Members, 1994-1999, )
Name Synonym	bitesize (Fehon, 2006, Weis and Nelson, 2006, Cavey et al., 2008, Maybeck and Röper, 2009) Bitesize (Pilot et al., 2006)
Secondary FlyBase IDs
	FBan0007343 FBan0031306 FBgn0010940 FBgn0038263 FBgn0038264 FBgn0038265 FBgn0038267 FBgn0051306 FBgn0053555 FBgn0063267 FBpp0082472 FBpp0082473 FBtr0083013 FBtr0083014
References ( 48 )
Generate a list of	All references relating to this gene ( 48 )
List References by type	Research paper  ( 8 ) Supplementary material  ( 6 ) Review  ( 3 ) Personal communication to FlyBase  ( 17 ) Abstract  ( 1 ) FlyBase analysis  ( 6 ) Stock list  ( 1 ) Website  ( 1 ) Curated genome annotation  ( 1 ) DNA/RNA sequence record  ( 4 )
Recent research papers (0)
	All research papers listed in FlyBase were published before 2011 Show research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...