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Gene Dmel\Hph

General Information
Symbol	Dmel\Hph	Species	D. melanogaster
Name	HIF prolyl hydroxylase	Annotation symbol	CG44015
Feature type	protein_coding_gene	FlyBase ID	FBgn0264785
Gene Model Status	Current	Stock availability	24 publicly available
Also Known As	fga, CG31543, l(3)02255, CG1114
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	82F7-82F8	Sequence location	3R:1,082,759..1,095,232 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene HIF prolyl hydroxylase is referred to in FlyBase by the symbol Dmel\Hph (CG44015, FBgn0264785). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: peptidyl-proline 4-dioxygenase activity; iron ion binding. There is experimental evidence that it is involved in the biological process: response to hypoxia; positive regulation of cell growth; protein localization; trachea morphogenesis; response to DNA damage stimulus; cellular response to hypoxia; terminal branching, open tracheal system. 43 alleles are reported. The phenotypes of these alleles are annotated with: embryonic/larval tracheal system; terminal tracheal cell. It has 3 annotated transcripts and 3 annotated polypeptides. Protein features are: Oxoglutarate/iron-dependent dioxygenase; Prolyl 4-hydroxylase, alpha subunit; Zinc finger, MYND-type. Gene sequence location is 3R:1082759..1095232.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 82F7-82F8   Limits computationally determined from genome sequence between P{PZ}l(3)0273302733 and P{EP}EP974
Experimentally Determined Cytological Location
Cytogenetic map Notes References 82F-82F   Location based on deficiency mapping with Df(3R)3-4.   (Ghabrial et al., 2011) 82F4-82F7   (determined by in situ hybridisation)   (Spradling et al., 1999) 82F3-82F6   (determined by in situ hybridisation)   (Szeged Stock Center, 1998-) 82F3-82F6   (determined by in situ hybridisation)   (Deak et al., 1997) 82F4-82F7     (BDGP Project Members, 1994-1999)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Hph for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Low-frequency RNA-Seq exon junction(s) not annotated. Gene model reviewed during 5.47
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Hph-RA FBtr0334275  NM_141268   2337   325 Hph-RB FBtr0334274  NM_169037   1603   278 Hph-RC FBtr0334276  NM_169036   2496   478
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Hph-PA   FBpp0306390   36.3   325   6.87     NP_649525   AAF52050 Hph-PB   FBpp0306389   30.6   278   6.67     NP_730908   AAN13268 Hph-PC   FBpp0306391   52.6   478   8.01     NP_730906   AAF52052
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Prolyl 4-hydroxylase, alpha subunit (IPR006620) Oxoglutarate/iron-dependent dioxygenase (IPR005123) Zinc finger, MYND-type (IPR002893)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA698304   AA820762   AA949707   AE014297 AAF52050   AE014297 AAF52052   AE014297 AAN13268   AF171785   AI108765   AI108991   AI113400   AI404129   AI455510   AQ026177   AW940922   AY051594 AAK93018   AY094896 AAM11249   BE662000   BG634485   BI172153   BI229282   BI229308   BI239651   BI239679   BI243307   BI352586   BI361825   BI361828   BI487207   BI609550   BI620990   BI622045   BI625886   BI627380   BI633742   BI634965   BI635190   BI638454   BI638577   BI640358   BI641235   BT001659 AAN71414   CK131769   CL705906   CO181015   CO186277   CO186283   CO277956   CO280269   CO291748   CO295249   CO305733   CO305975   CO323607   CO324704   CO325587   CO326927   CO327581   CO340971   CZ471530   CZ471669   CZ473605   CZ473669   CZ475867   CZ477222   CZ477223   CZ478814   CZ480545   CZ482246   CZ482247   CZ483242   CZ486530   CZ489448   CZ489449   EC086134   EC086405   EC200109   EC203471   EC205995   EC205996   EC210712   EC214825   EC221452   EC227190   EC227191   EC236112
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q8I0C2 Q9VN98 Q8SX21
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 4 -- 6   organism | faint & ubiquitous   (Fisher et al., 2012) embryonic stage 7 -- 8   anterior endoderm anlage   (Fisher et al., 2012) organism | faint & ubiquitous   (Fisher et al., 2012) posterior endoderm   (Fisher et al., 2012) embryonic stage 9 -- 10   anterior endoderm   (Fisher et al., 2012) organism | faint & ubiquitous   (Fisher et al., 2012) posterior endoderm   (Fisher et al., 2012) ventral ectoderm   (Fisher et al., 2012) embryonic stage 11 -- 12   anterior midgut primordium   (Fisher et al., 2012) organism | faint & ubiquitous   (Fisher et al., 2012) posterior midgut primordium   (Fisher et al., 2012)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
nucleoplasm inferred from direct assay (Frei and Edgar, 2004)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    19 central nervous system, larvae L3    14 central nervous system, pupae P8    9 head, virgin 1-day female    8 head, virgin 4-day female    10 head, virgin 20-day female    11 head, mated 1-day female    7 head, mated 4-day female    7 head, mated 20-day female    10 head, mated 1-day male    11 head, mated 4-day male    13 head, mated 20-day male    16 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    31 digestive system, 1-day adult    19 digestive system, 4-day adult    18 digestive system, 20-day adult    33 fat body, larvae L3 wandering    4 fat body, white prepupae    4 fat body, pupae P8    8 carcass, larvae L3 wandering    8 carcass, 1-day adult    8 carcass, 4-day adult    8 carcass, 20-day adult    10 ovary, virgin 4-day female    42 ovary, mated 4-day female    37 testis, mated 4-day male    17 accessory gland, mated 4-day male    8 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    19 central nervous system, larvae L3    14 central nervous system, pupae P8    9 head, virgin 1-day female    8 head, virgin 4-day female    10 head, virgin 20-day female    11 head, mated 1-day female    7 head, mated 4-day female    7 head, mated 20-day female    10 head, mated 1-day male    11 head, mated 4-day male    13 head, mated 20-day male    16 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    4 digestive system, larvae L3 wandering  (31) digestive system, 1-day adult    19 digestive system, 4-day adult    18 digestive system, 20-day adult  (33) fat body, larvae L3 wandering    4 fat body, white prepupae    4 fat body, pupae P8    8 carcass, larvae L3 wandering    8 carcass, 1-day adult    8 carcass, 4-day adult    8 carcass, 20-day adult    10 ovary, virgin 4-day female  (42) ovary, mated 4-day female  (37) testis, mated 4-day male    17 accessory gland, mated 4-day male    8 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    19 central nervous system, larvae L3    14 central nervous system, pupae P8    9 head, virgin 1-day female    8 head, virgin 4-day female    10 head, virgin 20-day female    11 head, mated 1-day female    7 head, mated 4-day female    7 head, mated 20-day female    10 head, mated 1-day male    11 head, mated 4-day male    13 head, mated 20-day male    16 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    31 digestive system, 1-day adult    19 digestive system, 4-day adult    18 digestive system, 20-day adult    33 fat body, larvae L3 wandering    4 fat body, white prepupae    4 fat body, pupae P8    8 carcass, larvae L3 wandering    8 carcass, 1-day adult    8 carcass, 4-day adult    8 carcass, 20-day adult    10 ovary, virgin 4-day female    42 ovary, mated 4-day female    37 testis, mated 4-day male    17 accessory gland, mated 4-day male    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    19 central nervous system, larvae L3    14 central nervous system, pupae P8    9 head, virgin 1-day female    8 head, virgin 4-day female    10 head, virgin 20-day female    11 head, mated 1-day female    7 head, mated 4-day female    7 head, mated 20-day female    10 head, mated 1-day male    11 head, mated 4-day male    13 head, mated 20-day male    16 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    31 digestive system, 1-day adult    19 digestive system, 4-day adult    18 digestive system, 20-day adult    33 fat body, larvae L3 wandering    4 fat body, white prepupae    4 fat body, pupae P8    8 carcass, larvae L3 wandering    8 carcass, 1-day adult    8 carcass, 4-day adult    8 carcass, 20-day adult    10 ovary, virgin 4-day female    42 ovary, mated 4-day female    37 testis, mated 4-day male    17 accessory gland, mated 4-day male    8 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    19 central nervous system, larvae L3    14 central nervous system, pupae P8    9 head, virgin 1-day female    8 head, virgin 4-day female    10 head, virgin 20-day female    11 head, mated 1-day female    7 head, mated 4-day female    7 head, mated 20-day female    10 head, mated 1-day male    11 head, mated 4-day male    13 head, mated 20-day male    16 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    31 digestive system, 1-day adult    19 digestive system, 4-day adult    18 digestive system, 20-day adult    33 fat body, larvae L3 wandering    4 fat body, white prepupae    4 fat body, pupae P8    8 carcass, larvae L3 wandering    8 carcass, 1-day adult    8 carcass, 4-day adult    8 carcass, 20-day adult    10 ovary, virgin 4-day female    42 ovary, mated 4-day female    37 testis, mated 4-day male    17 accessory gland, mated 4-day male    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    19 central nervous system, larvae L3    14 central nervous system, pupae P8    9 head, virgin 1-day female    8 head, virgin 4-day female    10 head, virgin 20-day female    11 head, mated 1-day female    7 head, mated 4-day female    7 head, mated 20-day female    10 head, mated 1-day male    11 head, mated 4-day male    13 head, mated 20-day male    16 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    4 digestive system, larvae L3 wandering  31 digestive system, 1-day adult    19 digestive system, 4-day adult    18 digestive system, 20-day adult  (33) fat body, larvae L3 wandering    4 fat body, white prepupae    4 fat body, pupae P8    8 carcass, larvae L3 wandering    8 carcass, 1-day adult    8 carcass, 4-day adult    8 carcass, 20-day adult    10 ovary, virgin 4-day female  (42) ovary, mated 4-day female  (37) testis, mated 4-day male    17 accessory gland, mated 4-day male    8 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    19 central nervous system, larvae L3    14 central nervous system, pupae P8    9 head, virgin 1-day female    8 head, virgin 4-day female    10 head, virgin 20-day female    11 head, mated 1-day female    7 head, mated 4-day female    7 head, mated 20-day female    10 head, mated 1-day male    11 head, mated 4-day male    13 head, mated 20-day male    16 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    31 digestive system, 1-day adult    19 digestive system, 4-day adult    18 digestive system, 20-day adult    33 fat body, larvae L3 wandering    4 fat body, white prepupae    4 fat body, pupae P8    8 carcass, larvae L3 wandering    8 carcass, 1-day adult    8 carcass, 4-day adult    8 carcass, 20-day adult    10 ovary, virgin 4-day female    42 ovary, mated 4-day female    37 testis, mated 4-day male    17 accessory gland, mated 4-day male    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    19 central nervous system, larvae L3    14 central nervous system, pupae P8    9 head, virgin 1-day female    8 head, virgin 4-day female    10 head, virgin 20-day female    11 head, mated 1-day female    7 head, mated 4-day female    7 head, mated 20-day female    10 head, mated 1-day male    11 head, mated 4-day male    13 head, mated 20-day male    16 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    31 digestive system, 1-day adult    19 digestive system, 4-day adult    18 digestive system, 20-day adult    33 fat body, larvae L3 wandering    4 fat body, white prepupae    4 fat body, pupae P8    8 carcass, larvae L3 wandering    8 carcass, 1-day adult    8 carcass, 4-day adult    8 carcass, 20-day adult    10 ovary, virgin 4-day female    42 ovary, mated 4-day female    37 testis, mated 4-day male    17 accessory gland, mated 4-day male    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    46 embryo 02-04hr    17 embryo 04-06hr    24 embryo 06-08hr    17 embryo 08-10hr    16 embryo 10-12hr    16 embryo 12-14hr    11 embryo 14-16hr    8 embryo 16-18hr    10 embryo 18-20hr    15 embryo 20-22hr    16 embryo 22-24hr    14 larva L1    7 larva L2    7 larva L3 12hr old    11 larva L3 puffstage 1-2    14 larva L3 puffstage 3-6    16 larva L3 puffstage 7-9    15 white prepupae new    13 white prepupae 12hr    23 white prepupae 24hr    19 pupae 2d postWPP    18 pupae 3d postWPP    10 pupae 4d postWPP    19 adult male 01day    17 adult male 05day    22 adult male 30day    21 adult female 01day    24 adult female 05day    33 adult female 30day    35 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (46) embryo 02-04hr    17 embryo 04-06hr    24 embryo 06-08hr    17 embryo 08-10hr    16 embryo 10-12hr    16 embryo 12-14hr    11 embryo 14-16hr    8 embryo 16-18hr    10 embryo 18-20hr    15 embryo 20-22hr    16 embryo 22-24hr    14 larva L1    7 larva L2    7 larva L3 12hr old    11 larva L3 puffstage 1-2    14 larva L3 puffstage 3-6    16 larva L3 puffstage 7-9    15 white prepupae new    13 white prepupae 12hr    23 white prepupae 24hr    19 pupae 2d postWPP    18 pupae 3d postWPP    10 pupae 4d postWPP    19 adult male 01day    17 adult male 05day    22 adult male 30day    21 adult female 01day    24 adult female 05day  (33) adult female 30day  (35) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    46 embryo 02-04hr    17 embryo 04-06hr    24 embryo 06-08hr    17 embryo 08-10hr    16 embryo 10-12hr    16 embryo 12-14hr    11 embryo 14-16hr    8 embryo 16-18hr    10 embryo 18-20hr    15 embryo 20-22hr    16 embryo 22-24hr    14 larva L1    7 larva L2    7 larva L3 12hr old    11 larva L3 puffstage 1-2    14 larva L3 puffstage 3-6    16 larva L3 puffstage 7-9    15 white prepupae new    13 white prepupae 12hr    23 white prepupae 24hr    19 pupae 2d postWPP    18 pupae 3d postWPP    10 pupae 4d postWPP    19 adult male 01day    17 adult male 05day    22 adult male 30day    21 adult female 01day    24 adult female 05day    33 adult female 30day    35 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    46 embryo 02-04hr    17 embryo 04-06hr    24 embryo 06-08hr    17 embryo 08-10hr    16 embryo 10-12hr    16 embryo 12-14hr    11 embryo 14-16hr    8 embryo 16-18hr    10 embryo 18-20hr    15 embryo 20-22hr    16 embryo 22-24hr    14 larva L1    7 larva L2    7 larva L3 12hr old    11 larva L3 puffstage 1-2    14 larva L3 puffstage 3-6    16 larva L3 puffstage 7-9    15 white prepupae new    13 white prepupae 12hr    23 white prepupae 24hr    19 pupae 2d postWPP    18 pupae 3d postWPP    10 pupae 4d postWPP    19 adult male 01day    17 adult male 05day    22 adult male 30day    21 adult female 01day    24 adult female 05day    33 adult female 30day    35 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    46 embryo 02-04hr    17 embryo 04-06hr    24 embryo 06-08hr    17 embryo 08-10hr    16 embryo 10-12hr    16 embryo 12-14hr    11 embryo 14-16hr    8 embryo 16-18hr    10 embryo 18-20hr    15 embryo 20-22hr    16 embryo 22-24hr    14 larva L1    7 larva L2    7 larva L3 12hr old    11 larva L3 puffstage 1-2    14 larva L3 puffstage 3-6    16 larva L3 puffstage 7-9    15 white prepupae new    13 white prepupae 12hr    23 white prepupae 24hr    19 pupae 2d postWPP    18 pupae 3d postWPP    10 pupae 4d postWPP    19 adult male 01day    17 adult male 05day    22 adult male 30day    21 adult female 01day    24 adult female 05day    33 adult female 30day    35 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (46) embryo 02-04hr    17 embryo 04-06hr    24 embryo 06-08hr    17 embryo 08-10hr    16 embryo 10-12hr    16 embryo 12-14hr    11 embryo 14-16hr    8 embryo 16-18hr    10 embryo 18-20hr    15 embryo 20-22hr    16 embryo 22-24hr    14 larva L1    7 larva L2    7 larva L3 12hr old    11 larva L3 puffstage 1-2    14 larva L3 puffstage 3-6    16 larva L3 puffstage 7-9    15 white prepupae new    13 white prepupae 12hr    23 white prepupae 24hr    19 pupae 2d postWPP    18 pupae 3d postWPP    10 pupae 4d postWPP    19 adult male 01day    17 adult male 05day    22 adult male 30day    21 adult female 01day    24 adult female 05day  (33) adult female 30day  (35) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    46 embryo 02-04hr    17 embryo 04-06hr    24 embryo 06-08hr    17 embryo 08-10hr    16 embryo 10-12hr    16 embryo 12-14hr    11 embryo 14-16hr    8 embryo 16-18hr    10 embryo 18-20hr    15 embryo 20-22hr    16 embryo 22-24hr    14 larva L1    7 larva L2    7 larva L3 12hr old    11 larva L3 puffstage 1-2    14 larva L3 puffstage 3-6    16 larva L3 puffstage 7-9    15 white prepupae new    13 white prepupae 12hr    23 white prepupae 24hr    19 pupae 2d postWPP    18 pupae 3d postWPP    10 pupae 4d postWPP    19 adult male 01day    17 adult male 05day    22 adult male 30day    21 adult female 01day    24 adult female 05day    33 adult female 30day    35 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    46 embryo 02-04hr    17 embryo 04-06hr    24 embryo 06-08hr    17 embryo 08-10hr    16 embryo 10-12hr    16 embryo 12-14hr    11 embryo 14-16hr    8 embryo 16-18hr    10 embryo 18-20hr    15 embryo 20-22hr    16 embryo 22-24hr    14 larva L1    7 larva L2    7 larva L3 12hr old    11 larva L3 puffstage 1-2    14 larva L3 puffstage 3-6    16 larva L3 puffstage 7-9    15 white prepupae new    13 white prepupae 12hr    23 white prepupae 24hr    19 pupae 2d postWPP    18 pupae 3d postWPP    10 pupae 4d postWPP    19 adult male 01day    17 adult male 05day    22 adult male 30day    21 adult female 01day    24 adult female 05day    33 adult female 30day    35 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    42 Schneider line 2 Sg4    26 embryonic 1182-4H    23 embryonic GM2    29 embryonic Kc167    72 embryonic S1    49 embryonic S3    33 leg disc CME L1    36 wing disc CME-W2    26 wing disc ML-DmD8    39 wing disc ML-DmD9    39 wing disc ML-DmD16-c3    27 wing disc ML-DmD21    18 wing disc ML-DmD32    36 haltere disc ML-DmD17-c3    22 eye-antennal disc ML-DmD11    20 antennal disc ML-DmD20-c5    16 mixed discs ML-DmD4-c1    21 CNS ML-DmBG1-c1    41 CNS ML-DmBG2-c2    26 tumorous blood cells mbn2    47 ovary fGS/OSS    69 ovary OSC    51 ovary OSS    19 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (42) Schneider line 2 Sg4  26 embryonic 1182-4H    23 embryonic GM2  (29) embryonic Kc167  (72) embryonic S1  (49) embryonic S3  (33) leg disc CME L1  (36) wing disc CME-W2  26 wing disc ML-DmD8  (39) wing disc ML-DmD9  (39) wing disc ML-DmD16-c3  (27) wing disc ML-DmD21    18 wing disc ML-DmD32  (36) haltere disc ML-DmD17-c3    22 eye-antennal disc ML-DmD11    20 antennal disc ML-DmD20-c5    16 mixed discs ML-DmD4-c1    21 CNS ML-DmBG1-c1  (41) CNS ML-DmBG2-c2  26 tumorous blood cells mbn2  (47) ovary fGS/OSS  (69) ovary OSC  (51) ovary OSS    19 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    42 Schneider line 2 Sg4    26 embryonic 1182-4H    23 embryonic GM2    29 embryonic Kc167    72 embryonic S1    49 embryonic S3    33 leg disc CME L1    36 wing disc CME-W2    26 wing disc ML-DmD8    39 wing disc ML-DmD9    39 wing disc ML-DmD16-c3    27 wing disc ML-DmD21    18 wing disc ML-DmD32    36 haltere disc ML-DmD17-c3    22 eye-antennal disc ML-DmD11    20 antennal disc ML-DmD20-c5    16 mixed discs ML-DmD4-c1    21 CNS ML-DmBG1-c1    41 CNS ML-DmBG2-c2    26 tumorous blood cells mbn2    47 ovary fGS/OSS    69 ovary OSC    51 ovary OSS    19 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    42 Schneider line 2 Sg4    26 embryonic 1182-4H    23 embryonic GM2    29 embryonic Kc167    72 embryonic S1    49 embryonic S3    33 leg disc CME L1    36 wing disc CME-W2    26 wing disc ML-DmD8    39 wing disc ML-DmD9    39 wing disc ML-DmD16-c3    27 wing disc ML-DmD21    18 wing disc ML-DmD32    36 haltere disc ML-DmD17-c3    22 eye-antennal disc ML-DmD11    20 antennal disc ML-DmD20-c5    16 mixed discs ML-DmD4-c1    21 CNS ML-DmBG1-c1    41 CNS ML-DmBG2-c2    26 tumorous blood cells mbn2    47 ovary fGS/OSS    69 ovary OSC    51 ovary OSS    19 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    42 Schneider line 2 Sg4    26 embryonic 1182-4H    23 embryonic GM2    29 embryonic Kc167    72 embryonic S1    49 embryonic S3    33 leg disc CME L1    36 wing disc CME-W2    26 wing disc ML-DmD8    39 wing disc ML-DmD9    39 wing disc ML-DmD16-c3    27 wing disc ML-DmD21    18 wing disc ML-DmD32    36 haltere disc ML-DmD17-c3    22 eye-antennal disc ML-DmD11    20 antennal disc ML-DmD20-c5    16 mixed discs ML-DmD4-c1    21 CNS ML-DmBG1-c1    41 CNS ML-DmBG2-c2    26 tumorous blood cells mbn2    47 ovary fGS/OSS    69 ovary OSC    51 ovary OSS    19 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (42) Schneider line 2 Sg4  26 embryonic 1182-4H    23 embryonic GM2  29 embryonic Kc167  (72) embryonic S1  (49) embryonic S3  (33) leg disc CME L1  (36) wing disc CME-W2  26 wing disc ML-DmD8  (39) wing disc ML-DmD9  (39) wing disc ML-DmD16-c3  27 wing disc ML-DmD21    18 wing disc ML-DmD32  (36) haltere disc ML-DmD17-c3    22 eye-antennal disc ML-DmD11    20 antennal disc ML-DmD20-c5    16 mixed discs ML-DmD4-c1    21 CNS ML-DmBG1-c1  (41) CNS ML-DmBG2-c2  26 tumorous blood cells mbn2  (47) ovary fGS/OSS  (69) ovary OSC  (51) ovary OSS    19 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    42 Schneider line 2 Sg4    26 embryonic 1182-4H    23 embryonic GM2    29 embryonic Kc167    72 embryonic S1    49 embryonic S3    33 leg disc CME L1    36 wing disc CME-W2    26 wing disc ML-DmD8    39 wing disc ML-DmD9    39 wing disc ML-DmD16-c3    27 wing disc ML-DmD21    18 wing disc ML-DmD32    36 haltere disc ML-DmD17-c3    22 eye-antennal disc ML-DmD11    20 antennal disc ML-DmD20-c5    16 mixed discs ML-DmD4-c1    21 CNS ML-DmBG1-c1    41 CNS ML-DmBG2-c2    26 tumorous blood cells mbn2    47 ovary fGS/OSS    69 ovary OSC    51 ovary OSS    19 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    42 Schneider line 2 Sg4    26 embryonic 1182-4H    23 embryonic GM2    29 embryonic Kc167    72 embryonic S1    49 embryonic S3    33 leg disc CME L1    36 wing disc CME-W2    26 wing disc ML-DmD8    39 wing disc ML-DmD9    39 wing disc ML-DmD16-c3    27 wing disc ML-DmD21    18 wing disc ML-DmD32    36 haltere disc ML-DmD17-c3    22 eye-antennal disc ML-DmD11    20 antennal disc ML-DmD20-c5    16 mixed discs ML-DmD4-c1    21 CNS ML-DmBG1-c1    41 CNS ML-DmBG2-c2    26 tumorous blood cells mbn2    47 ovary fGS/OSS    69 ovary OSC    51 ovary OSS    19 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    16 cold shock, 4-day adult    11 heat shock, 4-day adult    15 Cadmium 50 mM 6 hrs, larvae L3    10 Cadmium 50 mM 12 hrs, larvae L3    10 Cadmium 50 mM 48 hrs, 4-day adult    18 Cadmium 100 mM 48 hrs, 4-day adult    31 Copper 0.5 mM 12 hrs, larvae L3    9 Copper 15 mM 48 hrs, 4-day adult    19 Zinc 5 mM 12 hrs, larvae L3    10 Zinc 4.5 mM 48 hrs, 4-day adult    17 Ethanol 2.5% 3 hrs, larvae L3    28 Ethanol 5% 3 hrs, larvae L3    10 Ethanol 10% 3 hrs, larvae L3    7 Caffeine 1.5 mg/ml 4 hrs, larvae L3    10 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    28 Caffeine 25 mg/ml 48 hrs, 4-day adult    16 Paraquat 5 mM 48 hrs, 4-day adult    29 Paraquat 10 mM 48 hrs, 4-day adult    21 Rotenone 2 μg 12 hrs, larvae L3    10 Rotenone 8 μg 12 hrs, larvae L3    8 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    16 cold shock, 4-day adult    11 heat shock, 4-day adult    15 Cadmium 50 mM 6 hrs, larvae L3    10 Cadmium 50 mM 12 hrs, larvae L3    10 Cadmium 50 mM 48 hrs, 4-day adult    18 Cadmium 100 mM 48 hrs, 4-day adult  (31) Copper 0.5 mM 12 hrs, larvae L3    9 Copper 15 mM 48 hrs, 4-day adult    19 Zinc 5 mM 12 hrs, larvae L3    10 Zinc 4.5 mM 48 hrs, 4-day adult    17 Ethanol 2.5% 3 hrs, larvae L3  (28) Ethanol 5% 3 hrs, larvae L3    10 Ethanol 10% 3 hrs, larvae L3    7 Caffeine 1.5 mg/ml 4 hrs, larvae L3    10 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (28) Caffeine 25 mg/ml 48 hrs, 4-day adult    16 Paraquat 5 mM 48 hrs, 4-day adult  (29) Paraquat 10 mM 48 hrs, 4-day adult    21 Rotenone 2 μg 12 hrs, larvae L3    10 Rotenone 8 μg 12 hrs, larvae L3    8 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    16 cold shock, 4-day adult    11 heat shock, 4-day adult    15 Cadmium 50 mM 6 hrs, larvae L3    10 Cadmium 50 mM 12 hrs, larvae L3    10 Cadmium 50 mM 48 hrs, 4-day adult    18 Cadmium 100 mM 48 hrs, 4-day adult    31 Copper 0.5 mM 12 hrs, larvae L3    9 Copper 15 mM 48 hrs, 4-day adult    19 Zinc 5 mM 12 hrs, larvae L3    10 Zinc 4.5 mM 48 hrs, 4-day adult    17 Ethanol 2.5% 3 hrs, larvae L3    28 Ethanol 5% 3 hrs, larvae L3    10 Ethanol 10% 3 hrs, larvae L3    7 Caffeine 1.5 mg/ml 4 hrs, larvae L3    10 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    28 Caffeine 25 mg/ml 48 hrs, 4-day adult    16 Paraquat 5 mM 48 hrs, 4-day adult    29 Paraquat 10 mM 48 hrs, 4-day adult    21 Rotenone 2 μg 12 hrs, larvae L3    10 Rotenone 8 μg 12 hrs, larvae L3    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    16 cold shock, 4-day adult    11 heat shock, 4-day adult    15 Cadmium 50 mM 6 hrs, larvae L3    10 Cadmium 50 mM 12 hrs, larvae L3    10 Cadmium 50 mM 48 hrs, 4-day adult    18 Cadmium 100 mM 48 hrs, 4-day adult    31 Copper 0.5 mM 12 hrs, larvae L3    9 Copper 15 mM 48 hrs, 4-day adult    19 Zinc 5 mM 12 hrs, larvae L3    10 Zinc 4.5 mM 48 hrs, 4-day adult    17 Ethanol 2.5% 3 hrs, larvae L3    28 Ethanol 5% 3 hrs, larvae L3    10 Ethanol 10% 3 hrs, larvae L3    7 Caffeine 1.5 mg/ml 4 hrs, larvae L3    10 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    28 Caffeine 25 mg/ml 48 hrs, 4-day adult    16 Paraquat 5 mM 48 hrs, 4-day adult    29 Paraquat 10 mM 48 hrs, 4-day adult    21 Rotenone 2 μg 12 hrs, larvae L3    10 Rotenone 8 μg 12 hrs, larvae L3    8 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    16 cold shock, 4-day adult    11 heat shock, 4-day adult    15 Cadmium 50 mM 6 hrs, larvae L3    10 Cadmium 50 mM 12 hrs, larvae L3    10 Cadmium 50 mM 48 hrs, 4-day adult    18 Cadmium 100 mM 48 hrs, 4-day adult    31 Copper 0.5 mM 12 hrs, larvae L3    9 Copper 15 mM 48 hrs, 4-day adult    19 Zinc 5 mM 12 hrs, larvae L3    10 Zinc 4.5 mM 48 hrs, 4-day adult    17 Ethanol 2.5% 3 hrs, larvae L3    28 Ethanol 5% 3 hrs, larvae L3    10 Ethanol 10% 3 hrs, larvae L3    7 Caffeine 1.5 mg/ml 4 hrs, larvae L3    10 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    28 Caffeine 25 mg/ml 48 hrs, 4-day adult    16 Paraquat 5 mM 48 hrs, 4-day adult    29 Paraquat 10 mM 48 hrs, 4-day adult    21 Rotenone 2 μg 12 hrs, larvae L3    10 Rotenone 8 μg 12 hrs, larvae L3    8 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    16 cold shock, 4-day adult    11 heat shock, 4-day adult    15 Cadmium 50 mM 6 hrs, larvae L3    10 Cadmium 50 mM 12 hrs, larvae L3    10 Cadmium 50 mM 48 hrs, 4-day adult    18 Cadmium 100 mM 48 hrs, 4-day adult  31 Copper 0.5 mM 12 hrs, larvae L3    9 Copper 15 mM 48 hrs, 4-day adult    19 Zinc 5 mM 12 hrs, larvae L3    10 Zinc 4.5 mM 48 hrs, 4-day adult    17 Ethanol 2.5% 3 hrs, larvae L3  28 Ethanol 5% 3 hrs, larvae L3    10 Ethanol 10% 3 hrs, larvae L3    7 Caffeine 1.5 mg/ml 4 hrs, larvae L3    10 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  28 Caffeine 25 mg/ml 48 hrs, 4-day adult    16 Paraquat 5 mM 48 hrs, 4-day adult  29 Paraquat 10 mM 48 hrs, 4-day adult    21 Rotenone 2 μg 12 hrs, larvae L3    10 Rotenone 8 μg 12 hrs, larvae L3    8 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    16 cold shock, 4-day adult    11 heat shock, 4-day adult    15 Cadmium 50 mM 6 hrs, larvae L3    10 Cadmium 50 mM 12 hrs, larvae L3    10 Cadmium 50 mM 48 hrs, 4-day adult    18 Cadmium 100 mM 48 hrs, 4-day adult    31 Copper 0.5 mM 12 hrs, larvae L3    9 Copper 15 mM 48 hrs, 4-day adult    19 Zinc 5 mM 12 hrs, larvae L3    10 Zinc 4.5 mM 48 hrs, 4-day adult    17 Ethanol 2.5% 3 hrs, larvae L3    28 Ethanol 5% 3 hrs, larvae L3    10 Ethanol 10% 3 hrs, larvae L3    7 Caffeine 1.5 mg/ml 4 hrs, larvae L3    10 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    28 Caffeine 25 mg/ml 48 hrs, 4-day adult    16 Paraquat 5 mM 48 hrs, 4-day adult    29 Paraquat 10 mM 48 hrs, 4-day adult    21 Rotenone 2 μg 12 hrs, larvae L3    10 Rotenone 8 μg 12 hrs, larvae L3    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    16 cold shock, 4-day adult    11 heat shock, 4-day adult    15 Cadmium 50 mM 6 hrs, larvae L3    10 Cadmium 50 mM 12 hrs, larvae L3    10 Cadmium 50 mM 48 hrs, 4-day adult    18 Cadmium 100 mM 48 hrs, 4-day adult    31 Copper 0.5 mM 12 hrs, larvae L3    9 Copper 15 mM 48 hrs, 4-day adult    19 Zinc 5 mM 12 hrs, larvae L3    10 Zinc 4.5 mM 48 hrs, 4-day adult    17 Ethanol 2.5% 3 hrs, larvae L3    28 Ethanol 5% 3 hrs, larvae L3    10 Ethanol 10% 3 hrs, larvae L3    7 Caffeine 1.5 mg/ml 4 hrs, larvae L3    10 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    28 Caffeine 25 mg/ml 48 hrs, 4-day adult    16 Paraquat 5 mM 48 hrs, 4-day adult    29 Paraquat 10 mM 48 hrs, 4-day adult    21 Rotenone 2 μg 12 hrs, larvae L3    10 Rotenone 8 μg 12 hrs, larvae L3    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_26 mE1_20_mRNA_expression_cluster_03
External Data & Images
Linkouts	BDGP expression data • GH23732 RE70727
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal (with Df(3R)3-4) Hph02255 lethal | first instar larval stage Hph1 Hph64 Hph02255 lethal | first instar larval stage | recessive Hph1 lethal | larval stage Hph02255 lethal | pupal stage Hph9 lethal | recessive Hph82Fe-1 Hph82Fe-2 Hph02255 HphS030304 partially lethal - majority die | embryonic stage Hph02255 partially lethal - majority die | embryonic stage (with Df(3R)3-4) Hph02255 partially lethal - majority die | larval stage (with Df(3R)3-4) Hph02255 partially lethal - majority die | pupal stage (with Hph02255) HphS030304 partially lethal - majority die | pupal stage (with HphS030304) Hph02255 viable HphEY02317 Hphf03923 Sterility Allele fertile HphEY02317 Hphf03923 Other Phenotypes Allele cell growth defective | somatic clone, with Scer\GAL4Act5C.PP HphScer\UAS.cFa decreased cell size | somatic clone | wandering third instar larval stage Hph02255 developmental rate defective | larval stage | recessive Hph9 increased cell number, with Scer\GAL4en-e16E HphEP3200 size defective | somatic clone, with Scer\GAL4Act5C.PP HphEP3200 HphScer\UAS.cFa small body | adult stage (with Hph02255) HphS030304 small body | adult stage (with HphS030304) Hph02255 small body | pupal stage | recessive Hph9 Phenotype manifest in Allele embryonic/larval fat body | somatic clone Hph02255 embryonic/larval tracheal system Hph1 Hph784 eye | somatic clone Hph784 terminal tracheal cell Hph784
Classical Alleles ( 34 )
For All Classical Alleles Show
Allele of Hph Class Mutagen Stocks Known lesion Hph82Fe-2 ethyl nitrosourea 2 -- Hphf03923 piggyBac transposase 2 -- Hph02255 P-element activity 1 Yes Hph5-HA-1078 1 -- Hph5-HA-1681 1 -- Hph5-HA-2003 1 -- Hph82Fe-1 X ray 1 -- HphCB-0049-3 1 -- HphCB-0635-3 1 -- Hphd00335 P-element activity 1 -- Hphd00564 P-element activity 1 -- Hphd06295 1 -- Hphe00985 piggyBac transposase 1 -- Hphe02775 piggyBac transposase 1 -- Hphe04483 piggyBac transposase 1 -- HphEY02317 P-element activity 1 -- Hphf00762 piggyBac transposase 1 -- Hphf06722 piggyBac transposase 1 -- HphNP2662 1 -- HphNP3244 1 -- Hph1 Delta2-3 0 Yes Hph64 Delta2-3 0 Yes Hph784 ethyl methanesulfonate 0 -- Hph9 Delta2-3 0 Yes Hphd03880 P-element activity 0 -- Hphd03981 P-element activity 0 -- Hphd07676 P-element activity 0 -- Hphd10334 P-element activity 0 -- HphDG03101 0 -- HphEP3200 P-element activity 0 Yes HphII.2 P-element activity 0 Yes HphNP4401 0 -- HphS030304 Delta2-3 P-element activity 0 Yes Hphunspecified 0 --
Alleles Carried on Transgenic Constructs ( 9 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Hph Class Mutagen Stocks Known lesion HphHMS01196 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes HphKK100344 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes HphA.Scer\UAS in vitro construct - regulatory fusion 0 Yes HphB.Scer\UAS in vitro construct - regulatory fusion 0 Yes HphdsRNA.cBa in vitro construct - RNAi 0 Yes HphdsRNA.cLa in vitro construct - RNAi 0 Yes HphGD10291 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes HphNIG.1114R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes HphScer\UAS.cFa in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3R)3-4 (Lavista-Llanos et al., 2002, Carpenter, 1994, Carpenter, 1999, Ghabrial et al., 2011) Df(3R)6-7 (Szeged Stock Center, 1998-, Carpenter, 1999, Carpenter, 1994) Df(3R)ED5147 (Roote, 2004.7.20, Ryder and Roote, 2004.11.10) Df(3R)ED5156 (Ryder and Roote, 2004.11.10, Roote, 2004.7.20) Df(3R)ME15 (Carpenter, 1994, Carpenter, 1999)
Not disrupted in	Df(3R)2-2 (Spradling et al., 1999, BDGP Project Members, 1994-1999) Df(3R)110 (Carpenter, 1999, Carpenter, 1994)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD10291} NA P{KK100344} NA P{NIG.1114R} NA P{TRiP.HMS01196} NA P{UAS-fga.A} NA P{UAS-fga.B} NA P{UAS-Hph.F} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}HphEP3200 NA P{EPgy2}HphEY02317 NA P{XP}Hphd00335 NA P{XP}Hphd00564 NA P{XP}Hphd03880 NA P{XP}Hphd03981 NA P{XP}Hphd06295 NA P{XP}Hphd07676 NA P{XP}Hphd10334 NA miscellaneous insertions P{?PZ}Hph1 NA P{?PZ}Hph9 NA P{RS3}HphCB-0049-3 NA P{RS3}HphCB-0635-3 NA P{RS5}Hph5-HA-1078 NA P{RS5}Hph5-HA-1681 NA P{RS5}Hph5-HA-2003 NA P{UAS-Hph.F}HphII.2 NA P{wHy}HphDG03101 NA PBac{RB}Hphe00985 NA PBac{RB}Hphe02775 NA PBac{RB}Hphe04483 NA PBac{WH}Hphf00762 NA PBac{WH}Hphf03923 NA PBac{WH}Hphf06722 NA insertion of enhancer trap binary system P{GawB}HphNP2662 No P{GawB}HphNP3244 No P{GawB}HphNP4401 No insertion of enhancer trap P{lacW}HphS030304 No P{PZ}Hph02255 No
Gene Ontology: Function, Process & Cellular Component ( 14 unique terms )
Terms Based on Experimental Evidence ( 8 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
cellular response to hypoxia inferred from mutant phenotype (Bruick and McKnight, 2001) positive regulation of cell growth inferred from genetic interaction with CycD, Cdk4 (Frei and Edgar, 2004) inferred from mutant phenotype (Centanin et al., 2005) protein localization inferred from mutant phenotype (Lavista-Llanos et al., 2002) response to DNA damage stimulus inferred from mutant phenotype (Ravi et al., 2009) response to hypoxia inferred from mutant phenotype (Lavista-Llanos et al., 2002) terminal branching, open tracheal system inferred from mutant phenotype (Ghabrial et al., 2011) trachea morphogenesis inferred from mutant phenotype (Ghabrial et al., 2011)
Cellular Component
CV term Evidence References
nucleoplasm inferred from direct assay (Frei and Edgar, 2004)
Terms Based on Predictions or Assertions ( 6 terms )
Molecular Function
CV term Evidence References
iron ion binding inferred from electronic annotation with InterPro:IPR006620 (FlyBase Curators et al., 2004-) inferred from sequence model (Bruick and McKnight, 2001) L-ascorbic acid binding inferred from electronic annotation with InterPro:IPR006620 (FlyBase Curators et al., 2004-) peptidyl-proline 4-dioxygenase activity inferred from sequence or structural similarity with human EGLN1, human EGLN2, human EGLN3 (Bruick and McKnight, 2001) zinc ion binding inferred from electronic annotation with InterPro:IPR002893 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
oxidation-reduction process inferred from electronic annotation with InterPro:IPR005123, InterPro:IPR006620 (FlyBase Curators et al., 2004-) peptidyl-proline hydroxylation to 4-hydroxy-L-proline inferred from sequence or structural similarity with human EGLN1, human EGLN2, human EGLN3 (Bruick and McKnight, 2001)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene (FlyBase Genome Annotators, 2012) protein_coding_gene (FlyBase Genome Annotators, 2012)
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
Hph - Aats-lys anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hph - Arpc3A anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hph - Atx2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hph - CG10306 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hph - CG11266 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hph - CG15735 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hph - CG15784 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hph - CG1832 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hph - CG31694 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hph - CG3224 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hph - CG32344 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hph - CG4169 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hph - CG4806 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hph - CG6724 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hph - CG6937 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hph - CG8545 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hph - CG8939 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hph - Ccs anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hph - Cct5 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hph - Clbn anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hph - Dgp-1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hph - Hsp22 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hph - Hsp23 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hph - Imp anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hph - ImpL3 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hph - LRP1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hph - Mi-2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hph - NHP2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hph - Ns1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hph - P32 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hph - Pp2A-29B anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hph - Prp8 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hph - Rop anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hph - RpL35A anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hph - RpL7-like anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hph - Rpb8 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hph - Rpt1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hph - Rpt2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hph - Rrp4 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hph - Rrp46 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hph - SC35 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hph - SmD2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hph - SmD3 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hph - Srp68 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hph - Top1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hph - U3-55K anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hph - hyd anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hph - kst anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hph - larp anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hph - mts anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hph - nop5 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hph - pit anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hph - pont anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hph - ref(2)P anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hph - tws anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Hph allele Gene References
External Data
Linkouts
Orthologs
OrthoDB Orthologs (58) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6XPR22 Dipteran inclusive ortholog search EOG6G1MRG Insect inclusive ortholog search EOG60ZPT9 Arthropod inclusive ortholog search EOG6FJ6RF Metazoa inclusive ortholog search EOG6W196W
Orthologs in Drosophila Species (EOG6XPR22)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Hph     Drosophila simulans   Dsim\GD19772     Drosophila sechellia   Dsec\GM10798     Drosophila erecta   Dere\GG12715     Drosophila yakuba   Dyak\GE25458     Drosophila ananassae   Dana\GF18932     Drosophila pseudoobscura pseudoobscura   Dpse\GA16313     Drosophila persimilis   Dper\GL21637     Drosophila willistoni   Dwil\GK12967     Drosophila virilis   Dvir\GJ10149     Drosophila mojavensis   Dmoj\GI22545     Drosophila grimshawi   Dgri\GH17757
Orthologs in non-Drosophila Dipterans (EOG6G1MRG)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL002798   Anopheles gambiae Malaria mosquito  Agam\AGAP003523   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ008669   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ008668
Orthologs in non-Dipteran Insects (EOG60ZPT9)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB48884   Apis mellifera Western honey bee  Amel\GB48883   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG011018   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH18428   Atta cephalotes Leafcutter ant  Acep\ACEP10536   Camponotus floridanus Florida carpenter ant  Cflo\CFLO14644   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL13992   Linepithema humile Argentine ant  Lhum\LH11623   Linepithema humile Argentine ant  Lhum\LH15615   Pogonomyrmex barbatus Red harvester ant  Pbar\PB22817   Solenopsis invicta Red fire ant  Sinv\SINV20726   Acyrthosiphon pisum Pea aphid  Apim\ACYPI009943   Bombyx mori Silkmoth  Bmor\BGIBMGA005121   Bombyx mori Silkmoth  Bmor\BGIBMGA005120   Pediculus humanus Human body louse  Phum\PHUM515220   Tribolium castaneum Red flour beetle  Tcas\Hph
Orthologs in non-Insect Arthropods (EOG6FJ6RF)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\JGI_V11_347569   Daphnia pulex Water flea  Dpux\JGI_V11_347567   Daphnia pulex Water flea  Dpux\JGI_V11_64722   Ixodes scapularis Deer tick  Isca\ISCW000901
Orthologs in non-Arthropod Metazoa (EOG6W196W)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\egl-9   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_014247gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_026471gn   Danio rerio Zebrafish  Drer\egln1   Danio rerio Zebrafish  Drer\egln2   Danio rerio Zebrafish  Drer\egln3   Danio rerio Zebrafish  Drer\si:ch1073-423n4.1   Xenopus tropicalis Western clawed frog  Xtro\egln1   Xenopus tropicalis Western clawed frog  Xtro\egln2   Xenopus tropicalis Western clawed frog  Xtro\egln3   Gallus gallus Domestic chicken  Ggal\EGLN3   Gallus gallus Domestic chicken  Ggal\EGLN1   Mus musculus House mouse  Mmus\Egln1   Mus musculus House mouse  Mmus\ENSMUSG00000035105   Mus musculus House mouse  Mmus\Egln2   Rattus norvegicus Norway rat  Rnor\ENSRNOG00000042493   Rattus norvegicus Norway rat  Rnor\Egln3   Rattus norvegicus Norway rat  Rnor\Egln2   Rattus norvegicus Norway rat  Rnor\Egln1   Homo sapiens Human  Hsap\EGLN3   Homo sapiens Human  Hsap\EGLN2   Homo sapiens Human  Hsap\EGLN1
Human Orthologs (3)
Gene OMIM HGNC Hsap\EGLN3     Hsap\EGLN2     Hsap\EGLN1
AAA Orthologs (0) based on analysis using Dmel annotation version 4.3
No orthologs identified
Stocks & Reagents
Stocks Listed in FlyBase ( 24 )
Harvard	- P{XP}Hphd00335 - P{XP}Hphd00564 - P{XP}Hphd06295 - PBac{RB}Hphe00985 - PBac{RB}Hphe02775 - PBac{RB}Hphe04483 - PBac{WH}Hphf00762 - PBac{WH}Hphf03923 - PBac{WH}Hphf06722
Kyoto	113179 w*; P{GawB}HphNP3244 123022 w1118; P{RS3}HphCB-0049-3
VDRC	v103382 P{KK100344}VIE-260B
	More stocks available...
Genomic Clones ( 2 )
	BACR01D10 BACR42H10 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 60 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GH23732 RE46204 RE70727
Other clones	AF171785 DPiM_RE46204 DPiM_RE70727
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT30708 GH07477 GH08003 GH09037 GM19927 HL04243 LD29689 LP12767 RE14424 RE27034 RE27064 RE36201 RE36242 RE40892 RE46201 RH14347 RH39948 RH52263 RH53858 RH66387 RH68672 SD16460 SD20746 SD20905 SD23187 SD24455 SD27892
Other clones	16572 40488 55986 64396 69575 79237 146725 147297 167344 bs02d05 CK01.18D.A10 EC13341 EK018226 EK018326 EK127911 EK153536 EK190936 EK194545 EK196855 EK198106 EK209044 EK249325 EK249929 EP05004 EP07602 EP11646 LD24638
RNAi & Array Information
Linkouts
Antibody Information
	polyclonal (Frei and Edgar, 2004)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Hph CG1114 (Bruick and McKnight, 2001)
Source for database merge of	Source for merge of: CG1114 CG14665 (Taylor, 2001) Source for merge of: Hph anon-EST:Posey69 (Ashburner, 2004.6.30) Source for merge of: Hph CR31541 (FlyBase Genome Annotators, 2012) Source for merge of: Hph l(3)82Fe (Ghabrial et al., 2011) Source for merge of: Hph l(3)02255 (Lavista-Llanos et al., 2002) Source for merge of: Hph l(3)S030304 (Frei and Edgar, 2004)
Additional comments	Annotations CG31543 and CR31541 merged as CG44015 in release 5.47 of the genome annotation; CR31541 corresponds to alternative 3' UTR of CG31543. Merge supported by RNA-seq junction data. (FlyBase Genome Annotators, 2012) P{PZ}Hph02255 is inserted upstream of Hph. (Frei and Edgar, 2003) Annotations CG1114, CG14665 merged as CG31543 in release 3 of the genome annotation. (FlyBase Genome Annotators, 2002-2003)
Other Comments
	Renamed annotation (CR31541) in release 3 of the genome annotation. (FlyBase Genome Annotators, 2002-2003) A mutation in Hph causes major defects in embryonic tracheal development. (Wappner et al., 2002)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_141268 NM_169036 NM_169037 RefSeq (Proteins) • NP_649525 NP_730906 NP_730908 DDBJ / EMBL / GenBank • AA820762 AAF52050 AAF52052 AAK93018 AAM11249 AAN13268 AAN71414 AF171785 AI108765 AI404129 AI455510 AQ026177 AW940922 AY051594 AY094896 BE662000 BI361828 BI487207 BT001659 CL705906 CZ471530 CZ471669 CZ473605 CZ473669 CZ475867 CZ477222 CZ477223 CZ478814 CZ480545 CZ482246 CZ482247 CZ483242 CZ486530 CZ489448 CZ489449 Entrez Gene - A searchable database of RefSeq genes. • 40633 UniProtKB/TrEMBL • Q8I0C2 Q8SX21 Q9VN98
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Prolyl 4-hydroxylase, alpha subunit (IPR006620) Oxoglutarate/iron-dependent dioxygenase (IPR005123) Zinc finger, MYND-type (IPR002893) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • GH23732 RE70727
Linkouts
Synonyms & Secondary IDs ( 29 )
Reported As
Symbol Synonym	0303/04 (Deak et al., 1997) 31543 (Ravi et al., 2009) anon-EST:Posey69   CG1114 (Lavista-Llanos et al., 2002, Bruick and McKnight, 2001, Zimmermann et al., 2006) CG2676   CG14665 (Veraksa et al., 2002, ) CG31543 (Ni et al., 2010.12.1, Ashburner, 2004.6.30, Cuttell et al., 2008, Keleman et al., 2009.8.5) CG44015 (FlyBase Genome Annotators, 2012) CR31541   dHPH (Cuttell et al., 2008) Dm.egl-9 (Taylor, 2001) dmHPH (Bruick and McKnight, 2001) dPHD2 (van Uden et al., 2011) fga (Centanin et al., 2004, Centanin et al., 2003, Acevedo et al., 2007, Centanin et al., 2008, Centanin et al., 2005, Irisarri et al., 2009, Acevedo et al., 2010) Hph (Hazelett et al., 2012, Frise et al., 2010, Mukherjee et al., 2011, van Uden et al., 2011, Baird et al., 2006, Frei et al., 2008, Cuttell et al., 2008, FlyBase Genome Annotators, 2012, Japanese National Institute of Genetics, 2012.5.21, Gurudatta et al., 2012) hph (Datar et al., 2006, Doronkin et al., 2010, Duronio, 2004, Parrish et al., 2009) l(3)82Fe   l(3)02255 (French et al., 2003, Spradling et al., 1999, BDGP Project Members, 1994-1999, ) l(3)S030304   PHD (Rytkönen et al., 2011)
Name Synonym	Fatiga (van Uden et al., 2011, Chen et al., 2007, Frei et al., 2008) fatiga (Frei et al., 2005, Wappner et al., 2003, Centanin et al., 2003, Centanin et al., 2004, Centanin et al., 2003, Wappner et al., 2002, Dekanty et al., 2007, Xavier-Neto, 2005, Centanin et al., 2008, Centanin et al., 2005, Irisarri et al., 2009, Acevedo et al., 2010, Ghabrial et al., 2011) HIF-1a prolyl hyroxylase (Wappner et al., 2002) HIF prolyl 4-hydroxylase (Myllharju and Kivirikko, 2004) HIF prolyl hydroxylase (Bruick and McKnight, 2001, ) lethal (3) 82Fe   lethal (3) S030304   lopped (Ghabrial et al., 2011) prolyl-4-hydroxylase (Rytkönen et al., 2011)
Secondary FlyBase IDs
	FBgn0010773 FBgn0013577 FBgn0027674 FBgn0028167 FBgn0037306 FBgn0037308 FBgn0037309 FBgn0051543 FBgn0086689 FBgn0264652
References ( 76 )
Generate a list of	All references relating to this gene ( 76 )
List References by type	Research paper  ( 31 ) Supplementary material  ( 4 ) Review  ( 2 ) Personal communication to FlyBase  ( 15 ) Abstract  ( 12 ) FlyBase analysis  ( 6 ) Conference report  ( 1 ) Stock list  ( 3 ) Website  ( 1 ) Curated genome annotation  ( 1 )
Recent research papers ( 7 )
	Li et al., 2013, PLoS Genet. 9(1): e1003230 HIF- and Non-HIF-Regulated Hypoxic Responses Require the Estrogen-Related Receptor in Drosophila melanogaster. [FBrf0220675] Gurudatta et al., 2012, Dev. Biol. 369(1): 124--132 The BEAF insulator regulates genes involved in cell polarity and neoplastic growth. [FBrf0219796] Hazelett et al., 2012, G3 (Bethesda) 2(7): 789--802 Comparison of Parallel High-Throughput RNA Sequencing Between Knockout of TDP-43 and Its Overexpression Reveals Primarily Nonreciprocal and Nonoverlapping Gene Expression Changes in the Central Nervous System of Drosophila. [FBrf0219102] Ghabrial et al., 2011, PLoS Genet. 7(7): e1002087 A systematic screen for tube morphogenesis and branching genes in the Drosophila tracheal system. [FBrf0214368] Mukherjee et al., 2011, Science 332(6034): 1210--1213 Interaction between Notch and Hif-alpha in development and survival of Drosophila blood cells. [FBrf0214249] Rytkönen et al., 2011, Mol. Biol. Evol. 28(6): 1913--1926 Molecular Evolution of the Metazoan PHD-HIF Oxygen-Sensing System. [FBrf0213737] van Uden et al., 2011, PLoS Genet. 7(1): e1001285 Evolutionary Conserved Regulation of HIF-1β by NF-κB. [FBrf0212948] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...