FB2022_02, released March 29, 2022

Gene: Dmel\Hph

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General Information
Symbol
Dmel\Hph
Species
D. melanogaster
Name
HIF prolyl hydroxylase
Annotation Symbol
CG44015
Feature Type
protein_coding_gene
FlyBase ID
FBgn0264785
Gene Model Status
Current
Stock Availability
18 publicly available
Gene Summary
HIF prolyl hydroxylase (Hph) encodes the prolyl-4 hydroxylase that hydroxylases proline 850a of the product of sima, which is the alpha-subunit of the hypoxia inducible factor (HIF). The product of Hph regulates growth through both independent and dependent mechanisms of the product of sima. [Date last reviewed: 2019-03-07] (FlyBase Gene Snapshot)
All Summaries
Also Known As

fatiga, fga, l(3)02255, PHD

Key Links
Genomic Location
Cytogenetic map
82F7-82F8
Sequence location
Recombination map
3-47.5
RefSeq locus
NT_033777 REGION:5257037..5269507
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (14 terms)
Molecular Function (5 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
enables peptidyl-proline dioxygenase activity
inferred from direct assay
(Arquier et al., 2006)
Terms Based on Predictions or Assertions (5 terms)
CV Term
Evidence
References
enables ferrous iron binding
inferred from biological aspect of ancestor with PANTHER:PTN004393218
(assigned by GO_Central )
(Gaudet et al., 2011)
enables iron ion binding
inferred from sequence model
(Bruick and McKnight, 2001)
enables L-ascorbic acid binding
inferred from electronic annotation with InterPro:IPR006620
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
enables peptidyl-proline 4-dioxygenase activity
inferred from sequence or structural similarity with HGNC:1232,HGNC:14660,HGNC:14661
(Bruick and McKnight, 2001)
enables peptidyl-proline dioxygenase activity
inferred from biological aspect of ancestor with PANTHER:PTN004393218
(assigned by GO_Central )
(Gaudet et al., 2011)
Biological Process (8 terms)
Terms Based on Experimental Evidence (7 terms)
CV Term
Evidence
References
involved_in cellular response to hypoxia
inferred from mutant phenotype
(Bruick and McKnight, 2001)
involved_in peptidyl-proline hydroxylation
inferred from direct assay
(Arquier et al., 2006)
involved_in positive regulation of cell growth
inferred from mutant phenotype
(Centanin et al., 2005)
inferred from genetic interaction with FLYBASE:CycD; FB:FBgn0010315, FLYBASE:Cdk4; FB:FBgn0016131
(Frei and Edgar, 2004)
involved_in protein export from nucleus
inferred from mutant phenotype
(Irisarri et al., 2009)
involved_in protein localization
inferred from mutant phenotype
(Lavista-Llanos et al., 2002)
involved_in response to hypoxia
inferred from mutant phenotype
(Lavista-Llanos et al., 2002)
involved_in terminal branching, open tracheal system
inferred from high throughput mutant phenotype
(Ghabrial et al., 2011)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
involved_in cellular response to hypoxia
inferred from biological aspect of ancestor with PANTHER:PTN004393218
(assigned by GO_Central )
(Gaudet et al., 2011)
involved_in peptidyl-proline hydroxylation to 4-hydroxy-L-proline
inferred from sequence or structural similarity with HGNC:1232,HGNC:14660,HGNC:14661
(Bruick and McKnight, 2001)
Cellular Component (1 term)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
located_in nucleoplasm
inferred from direct assay
(Frei and Edgar, 2004)
Terms Based on Predictions or Assertions (0 terms)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Snapshot
HIF prolyl hydroxylase (Hph) encodes the prolyl-4 hydroxylase that hydroxylases proline 850a of the product of sima, which is the alpha-subunit of the hypoxia inducible factor (HIF). The product of Hph regulates growth through both independent and dependent mechanisms of the product of sima. [Date last reviewed: 2019-03-07]
Gene Group (FlyBase)
PEPTIDYL-PROLINE DIOXYGENASES -
Peptidyl-proline dioxygenases catalyze the hydroxylation of peptidyl L-proline to peptidyl hydroxy-L-proline, where 2-oxoglutarate and one other act as hydrogen or electron donors with incorporation of one atom of oxygen into each donor.
Summary (Interactive Fly)

oxygen sensor - a specific prolyl-4-hydroxylases required for hydroxylation of key prolyl residues in the HIFα sequence - Fe (II) and 2-oxoglutarate dependent dioxygenase superfamily protein that uses O as a co-substrate for catalysis - involved in tracheal development, oogenesis and drives cell growth downstream of Cyclin D

Gene Model and Products
Number of Transcripts
4
Number of Unique Polypeptides
3

Please see the JBrowse view of Dmel\Hph for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure New Section
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry Q8SX21)

If you don't see the viewer to the right, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Comments on Gene Model

Gene model reviewed during 5.47

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.53

Sequence Ontology: Class of Gene
nuclear_gene
(FlyBase Genome Annotators, 2012)
protein_coding_gene
(FlyBase Genome Annotators, 2012)
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Hph-RA
FBtr0334275
NM_141268
2337
325
Hph-RB
FBtr0334274
NM_169037
1607
278
Hph-RC
FBtr0334276
NM_169036
2496
478
Hph-RD
FBtr0344333
NM_001300242
3171
478
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
Hph-PA
FBpp0306390
36.3
325
6.87
NP_649525
AAF52050
Hph-PB
FBpp0306389
30.6
278
6.67
NP_730908
AAN13268
Hph-PC
FBpp0306391
52.6
478
8.01
NP_730906
AAF52052
Hph-PD
FBpp0310716
52.6
478
8.01
NP_001287171
AHN57170
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

478 aa isoforms: Hph-PC, Hph-PD
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Hph using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1 -- 3
organism

Comment: maternally deposited

(Fisher et al., 2012)
embryonic stage 4 -- 6
organism | faint | ubiquitous
(Fisher et al., 2012)
embryonic stage 7 -- 8
anterior endoderm anlage
(Fisher et al., 2012)
organism | faint | ubiquitous
(Fisher et al., 2012)
posterior endoderm
(Fisher et al., 2012)
embryonic stage 9 -- 10
anterior endoderm
(Fisher et al., 2012)
organism | faint | ubiquitous
(Fisher et al., 2012)
posterior endoderm
(Fisher et al., 2012)
ventral ectoderm
(Fisher et al., 2012)
embryonic stage 11 -- 12
anterior midgut primordium
(Fisher et al., 2012)
organism | faint | ubiquitous
(Fisher et al., 2012)
posterior midgut primordium
(Fisher et al., 2012)
RT-PCR
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage -- embryonic stage
organism
(Acevedo et al., 2010)
Additional Descriptive Data

The Hph-RA and Hph-RB transcripts are detected at all stages of development by RT-PCR but only Hph-RB is significantly upregulated in adults. Hph-RB but not Hph-RA is induced by hypoxia.

(Acevedo et al., 2010)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in nucleoplasm
inferred from direct assay
(Frei and Edgar, 2004)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Hph in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 34 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 10 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Hph
Transgenic constructs containing regulatory region of Hph
Aberrations (Deficiencies and Duplications) ( 7 )
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal (with Df(3R)3-4)
lethal | larval stage
lethal | recessive
lethal - all die before end of first instar larval stage
lethal - all die before end of first instar larval stage | recessive
lethal - all die before end of pupal stage
partially lethal - majority die (with Hph02255)
partially lethal - majority die (with HphS030304)
partially lethal - majority die | embryonic stage
partially lethal - majority die | embryonic stage (with Df(3R)3-4)
partially lethal - majority die | larval stage (with Df(3R)3-4)
viable
Sterility
Allele
fertile
Other Phenotypes
Allele
abnormal cell growth | somatic clone, with Scer\GAL4Act5C.PP
abnormal cell migration, with Scer\GAL4slbo.2.6
abnormal developmental rate | larval stage | recessive
abnormal size | somatic clone, with Scer\GAL4Act5C.PP
decreased body size | adult stage (with Hph02255)
decreased body size | adult stage (with HphS030304)
decreased body size | pupal stage | recessive
decreased cell size | somatic clone | wandering third instar larval stage
increased cell number, with Scer\GAL4en-e16E
some die during first instar larval stage
some die during first instar larval stage | recessive
some die during pupal stage
some die during pupal stage (with Hph02255)
some die during pupal stage (with HphS030304)
Phenotype manifest in
Allele
border follicle cell, with Scer\GAL4slbo.2.6
embryonic/larval fat body | somatic clone
embryonic/larval tracheal system
eye | somatic clone
terminal tracheal cell
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (3)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\EGLN3
12 of 15
Yes
Yes
1  
Hsap\EGLN1
11 of 15
No
Yes
Hsap\EGLN2
9 of 15
No
Yes
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (3)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Egln3
12 of 15
Yes
Yes
Mmus\Egln1
11 of 15
No
Yes
Mmus\Egln2
8 of 15
No
Yes
Rattus norvegicus (Norway rat) (4)
Rnor\Egln3
9 of 13
Yes
Yes
Rnor\Egln2
8 of 13
No
Yes
Rnor\Egln1
7 of 13
No
Yes
Rnor\LOC690182
2 of 13
No
Yes
Xenopus tropicalis (Western clawed frog) (3)
Xtro\egln1
10 of 12
Yes
Yes
Xtro\egln2
10 of 12
Yes
Yes
Xtro\egln3
5 of 12
No
Yes
Danio rerio (Zebrafish) (4)
Drer\egln1a
12 of 15
Yes
Yes
Drer\egln1b
11 of 15
No
Yes
Drer\egln2
9 of 15
No
Yes
Drer\egln3
7 of 15
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (1)
Cele\egl-9
10 of 15
Yes
Yes
Arabidopsis thaliana (thale-cress) (0)
No records found.
Saccharomyces cerevisiae (Brewer's yeast) (0)
No records found.
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Other Organism Orthologs (via OrthoDB)
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (0)
No records found.
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 1 )
    Human Ortholog
    Disease
    Evidence
    References
    EGLN1; egl-9 family hypoxia inducible factor 1
    model of  familial erythrocytosis 3
    IEA
    (FlyBase, 2019-)
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    EGLN3; egl-9 family hypoxia inducible factor 3
    12 of 15
    606426
         
        EGLN1; egl-9 family hypoxia inducible factor 1
        11 of 15
        606425
        EGLN2; egl-9 family hypoxia inducible factor 2
        9 of 15
        606424
            Functional Complementation Data
            Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
            Interactions
            Summary of Physical Interactions
            esyN Network Diagram
            Show neighbor-neighbor interactions:
            Select Layout:
            Legend:
            Protein
            RNA
            Selected Interactor(s)
            Interactions Browser
            View in Interactions Browser
            Please see the Physical Interaction reports below for full details
            RNA-RNA
            Physical Interaction
            Assay
            References
            Hph - mir-190
            luminiscence technology, necessary binding region
            (De Lella Ezcurra et al., 2016)
            Summary of Genetic Interactions
            esyN Network Diagram
            esyN Network Key:
            Suppression
            Enhancement
            View in Interactions Browser
            Please look at the allele data for full details of the genetic interactions
            Starting gene(s)
            Interaction type
            Interacting gene(s)
            Reference
            Hph
            suppressible
            mRpL12
            (Frei et al., 2005)
            Starting gene(s)
            Interaction type
            Interacting gene(s)
            Reference
            Cdk4|CycD
            suppressible
            Hph
            (Frei and Edgar, 2004)
            sima
            suppressible
            Hph
            (Doronkin et al., 2010)
            External Data
            Linkouts
            DroID - A comprehensive database of gene and protein interactions.
            MIST (protein-protein) - An integrated Molecular Interaction Database
            Pathways
            Signaling Pathways (FlyBase)
            Metabolic Pathways
            FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
            External Data
            Linkouts
            Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
            Genomic Location and Detailed Mapping Data
            Chromosome (arm)
            3R
            Recombination map
            3-47.5
            Cytogenetic map
            82F7-82F8
            Sequence location
            FlyBase Computed Cytological Location
            Cytogenetic map
            Evidence for location
            82F7-82F8
            Limits computationally determined from genome sequence between P{PZ}l(3)0273302733 and P{EP}EP974
            Experimentally Determined Cytological Location
            Cytogenetic map
            Notes
            References
            82F-82F
            (Ghabrial et al., 2011)
            Location based on deficiency mapping with Df(3R)3-4.
            (Ghabrial et al., 2011)
            82F4-82F7
            (determined by in situ hybridisation)
            (Spradling et al., 1999)
            82F3-82F6
            (determined by in situ hybridisation)
            (Szeged Stock Center, 1998-, Deak et al., 1997)
            82F4-82F7
            (BDGP Project Members, 1994-1999)
            Experimentally Determined Recombination Data
            Location

            3-47.5

            (FlyBase, 2016)

            3-44.1

            (Comeron et al., 2012)
            Left of (cM)
            Right of (cM)
            Notes
            Stocks and Reagents
            Stocks (18)
            Genomic Clones (31)
            cDNA Clones (29)
             

            Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

            cDNA clones, fully sequenced
            BDGP DGC clones
            Other clones
            Drosophila Genomics Resource Center cDNA clones

            For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

            cDNA Clones, End Sequenced (ESTs)
            BDGP DGC clones
            Other clones
            RNAi and Array Information
            Linkouts
            GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
            Antibody Information
            Laboratory Generated Antibodies
             

            polyclonal

            (Frei and Edgar, 2004)
            Commercially Available Antibodies
             
            Other Information
            Relationship to Other Genes
            Source for database identify of

            Source for identity of: Hph CG1114

            (Bruick and McKnight, 2001)
            Source for database merge of

            Source for merge of: CG1114 CG14665

            (Taylor, 2001)

            Source for merge of: Hph l(3)02255

            (Lavista-Llanos et al., 2002)

            Source for merge of: Hph anon- EST:Posey69

            (Ashburner, 2004.6.30)

            Source for merge of: Hph l(3)S030304

            (Frei and Edgar, 2004)

            Source for merge of: Hph l(3)82Fe

            (Ghabrial et al., 2011)

            Source for merge of: Hph CR31541

            (FlyBase Genome Annotators, 2012)
            Additional comments

            l(3)L3051 may correspond to Hph: the P{lacW}l(3)L3051L3051 insertion maps within the transcription unit.

            (Gene Disruption Project members, 2015.10.8)

            Annotations CG31543 and CR31541 merged as CG44015 in release 5.47 of the genome annotation; CR31541 corresponds to alternative 3' UTR of CG31543. Merge supported by RNA-seq junction data.

            (FlyBase Genome Annotators, 2012)

            P{PZ}Hph02255 is inserted upstream of Hph.

            (Frei and Edgar, 2003)

            Annotations CG1114, CG14665 merged as CG31543 in release 3 of the genome annotation.

            (FlyBase Genome Annotators, 2002-2003)
            Other Comments

            sima protein nuclear localization is affected in Hph mutant embryos.

            (Irisarri et al., 2009)

            Renamed annotation (CR31541) in release 3 of the genome annotation.

            (FlyBase Genome Annotators, 2002-2003)

            A mutation in Hph causes major defects in embryonic tracheal development.

            (Wappner et al., 2002)
            Origin and Etymology
            Discoverer
            Etymology
            Identification
            External Crossreferences and Linkouts ( 71 )
            Sequence Crossreferences
            NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
            GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
            GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
            RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
            UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
            UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
            Other crossreferences
            AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
            BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
            Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
            DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
            EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
            Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
            FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
            Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
            FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
            GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
            iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
            InterPro - A database of protein families, domains and functional sites
            KEGG Genes - Molecular building blocks of life in the genomic space.
            MARRVEL_MODEL - MARRVEL (model organism gene)
            Linkouts
            DroID - A comprehensive database of gene and protein interactions.
            Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
            MIST (protein-protein) - An integrated Molecular Interaction Database
            Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
            Synonyms and Secondary IDs (32)
            Reported As
            Symbol Synonym
            0303/04
            (Deak et al., 1997)
            31543
            (Ravi et al., 2009)
            CG1114
            (Zimmermann et al., 2006, Lavista-Llanos et al., 2002, Bruick and McKnight, 2001)
            CG14665
            (Veraksa et al., 2002)
            CG2676
            CG31543
            (Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Cuttell et al., 2008, Ashburner, 2004.6.30)
            CG44015
            (Meadows, 2019.11.20, FlyBase Genome Annotators, 2012)
            CR31541
            Dm.egl-9
            (Taylor, 2001)
            Fatiga
            (Barretto et al., 2020)
            Fga
            (Abla et al., 2020, Chen et al., 2019)
            FgaB
            (Perez-Perri et al., 2016)
            Hph
            (Goyal et al., 2022, Dorogova et al., 2020, Texada et al., 2020, Best, 2019, Kuhn et al., 2019, Texada et al., 2019, Crocker et al., 2016, Sarov et al., 2016, Dong et al., 2015, Ashwal-Fluss et al., 2014, Chen et al., 2014, Pascual-Garcia et al., 2014, FlyBase Genome Annotators, 2012, Gurudatta et al., 2012, Hazelett et al., 2012, Japanese National Institute of Genetics, 2012.5.21, Mukherjee et al., 2011, van Uden et al., 2011, Frise et al., 2010, Cuttell et al., 2008, Frei et al., 2008, Baird et al., 2006)
            PHD
            (Bajgar et al., 2021, Dong et al., 2015, Rytkönen et al., 2011)
            anon-EST:Posey69
            dHPH
            (Cuttell et al., 2008)
            dPHD
            (Arquier et al., 2006)
            dPHD2
            (van Uden et al., 2011)
            dmHPH
            (Bruick and McKnight, 2001)
            fatiga
            (De Lella Ezcurra et al., 2016)
            fga
            (Bertolin et al., 2016, De Lella Ezcurra et al., 2016, Zhou and Haddad, 2013, Acevedo et al., 2010, Irisarri et al., 2009, Centanin et al., 2008, Acevedo et al., 2007, Centanin et al., 2005, Centanin et al., 2004, Centanin et al., 2003)
            hph
            (Mazina et al., 2020, Dong et al., 2015, Doronkin et al., 2010, Parrish et al., 2009, Datar et al., 2006, Duronio, 2004)
            l(3)02255
            (French et al., 2003, Spradling et al., 1999, BDGP Project Members, 1994-1999)
            l(3)82Fe
            l(3)S030304
            Name Synonyms
            Fatiga
            (Chen et al., 2019, Bandarra et al., 2015, Mandilaras et al., 2013, van Uden et al., 2011, Frei et al., 2008, Chen et al., 2007)
            HIF prolyl 4-hydroxylase
            (Myllharju and Kivirikko, 2004)
            HIF prolyl hydroxylase
            (Doronkin et al., 2010, Bruick and McKnight, 2001)
            HIF-1a prolyl hyroxylase
            (Wappner et al., 2002)
            fatiga
            (Misra et al., 2017, Bertolin et al., 2016, Bandarra et al., 2015, Dong et al., 2015, Wang et al., 2015, Zhou and Haddad, 2013, Ghabrial et al., 2011, Harrison and Haddad, 2011, Acevedo et al., 2010, Irisarri et al., 2009, Centanin et al., 2008, Dekanty et al., 2007, Centanin et al., 2005, Frei et al., 2005, Xavier-Neto, 2005, Centanin et al., 2004, Centanin et al., 2003, Centanin et al., 2003, Wappner et al., 2003, Wappner et al., 2002)
            lethal (3) 82Fe
            lethal (3) S030304
            lopped
            (Ghabrial et al., 2011)
            prolyl-4-hydroxylase
            (Rytkönen et al., 2011)
            Secondary FlyBase IDs
            • FBgn0264652
            • FBgn0086689
            • FBgn0028167
            • FBgn0051543
            • FBgn0037306
            • FBgn0027674
            • FBgn0010773
            • FBgn0037308
            • FBgn0013577
            • FBgn0037309
            Datasets (8)
            Study focus (0)
            Experimental Role
            Project
            Project Type
            Title
            Study result (8)
            Result
            Result Type
            Title
            scRNAseq_2020_Cattenoz_NI_seq_clustering
            Clustering analysis of hemocytes from non-infested third instar larvae
            scRNAseq_2020_Cattenoz_WI_seq_clustering
            Clustering analysis of hemocytes from wasp-infested third instar larvae
            scRNAseq_2020_Cho_NI72LG_seq_clustering
            Clustering analysis of lymph gland cells from non-infested larvae at 72 h after egg-laying
            scRNAseq_2020_Cho_NI96LG_seq_clustering
            Clustering analysis of lymph gland cells from non-infested larvae at 96 h after egg-laying
            scRNAseq_2020_Cho_NI120LG_seq_clustering
            Clustering analysis of lymph gland cells from non-infested larvae at 120 h after egg-laying
            scRNAseq_2020_Cho_WI96LG_seq_clustering
            Clustering analysis of lymph gland cells from wasp-infested larvae at 96 h after egg-laying
            scRNAseq_2020_Cho_NI96HL_seq_clustering
            Clustering analysis of circulating hemocytes from non-infested larvae at 96 h after egg-laying
            scRNAseq_2020_Cho_NI120HL_seq_clustering
            Clustering analysis of circulating hemocytes from non-infested larvae at 120 h after egg-laying
            References (111)