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Gene Dmel\Mcr

General Information
Symbol	Dmel\Mcr	Species	D. melanogaster
Name	Macroglobulin complement-related	Annotation symbol	CG7586
Feature type	protein_coding_gene	FlyBase ID	FBgn0264800
Gene Model Status	Current	Stock availability	6 publicly available
Also Known As	Tep6, dTEPVI
Genomic Location
Chromosome (arm)	2L	Recombination map	2-
Cytogenetic map	28E1-28E3	Sequence location	2L:8,074,117..8,082,982 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Macroglobulin complement-related is referred to in FlyBase by the symbol Dmel\Mcr (CG7586, FBgn0264800). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: protein binding; eukaryotic cell surface binding. There is experimental evidence that it is involved in the biological process: response to yeast; lateral inhibition; antibacterial humoral response; phagocytosis, engulfment. 5 alleles are reported. The phenotypes of these alleles are annotated with: trichogen cell; chaeta. It has one annotated transcript and one annotated polypeptide. Protein features are: A-macroglobulin complement component; Alpha-2-macroglobulin; Alpha-2-macroglobulin, N-terminal; Alpha-2-macroglobulin, N-terminal 2; Alpha-macroglobulin, receptor-binding; Low-density lipoprotein (LDL) receptor class A repeat; Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid. Gene sequence location is 2L:8074117..8082982.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 28E1-28E3   Limits computationally determined from genome sequence between P{EP}poeEP737 and P{lacW}l(2)k16919k16919&P{lacW}Bsgk09030
Experimentally Determined Cytological Location
Cytogenetic map Notes References 28D-28E     (Crowley, 1997.2.6) 28D-28E     (Crowley et al., 1993)
Experimentally Determined Recombination Data
Location	2- (Crowley, 1997.2.6)
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Mcr for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.45
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Mcr-RA FBtr0079543  NM_079949   6296   1760
Additional Transcript Data & Comments
Reported size (kB)	8 (northern blot) (Vallejo and Leon, 1989)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Mcr-PA   FBpp0079165   202.8   1760   6.42     NP_524688   AAF52601
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Low-density lipoprotein (LDL) receptor class A repeat (IPR002172) Alpha-2-macroglobulin, N-terminal (IPR002890) Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid (IPR008930) Alpha-macroglobulin, receptor-binding (IPR009048) Alpha-2-macroglobulin, N-terminal 2 (IPR011625) A-macroglobulin complement component (IPR011626) Alpha-2-macroglobulin (IPR001599)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA441134   AA540366   AA940947   AA941816   AE014134 AAF52601   AW942672   AY058526 AAL13755   BF498495   BG638108   BG638495   BI232287   BI238333   BI366429   BI369201   BP557996   BP557997   CO185606   CO187745   CO190342   CO192523   CO262542   CO265525   CO266437   CO270990   CO279247   CO284775   CO288028   CO291458   CO292492   CO294112   CO297366   CO299073   CO299681   CO301764   CO306097   CO308401   CO318188   CO319000   CO319293   CO329532   CO332073   CZ486447   CZ486448   EC064456   EC066954   EC070697   EC072859   EC078832   EC085280   EC085489   EC086204   EC086590   EC089600   EC089787   EC201375   EC204483   EC205221   EC207564   EC208141   EC210150   EC210396   EC217328   EC218290   EC226225   EC230379   EC230918   EC234206   EC245342   EC248308   ES694186   EV575666   EV594571   GH748124   GH750232   GH771280   GH775112   GH778876   GH778947   GH785448   GH795576   GH798302   GH803060   GH806005   GH810241   GH812864   GH813311   GH830885   GH834910   GH862486   GH871134   GH873017   GH876188   GH877263   GH882872   GH885271   GH887134   GH907778   GH915414   GH922925   GH924316   GH928566   GH931252   Y11116
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VLT3
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
No Assay Recorded Stage Tissue/Position (including subcellular localization) Reference embryonic stage   presumptive embryonic/larval peripheral nervous system   (Vallejo and Leon, 1989) spermatogenesis & adult stage   testis   (Vallejo and Leon, 1989) spermatocyte   (Vallejo and Leon, 1989)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    32 central nervous system, larvae L3    12 central nervous system, pupae P8    14 head, virgin 1-day female    8 head, virgin 4-day female    6 head, virgin 20-day female    8 head, mated 1-day female    6 head, mated 4-day female    7 head, mated 20-day female    6 head, mated 1-day male    10 head, mated 4-day male    10 head, mated 20-day male    14 salivary gland, larvae L3 wandering    5 salivary gland, white prepupae    10 digestive system, larvae L3 wandering    4 digestive system, 1-day adult    2 digestive system, 4-day adult    3 digestive system, 20-day adult    3 fat body, larvae L3 wandering    3 fat body, white prepupae    8 fat body, pupae P8    11 carcass, larvae L3 wandering    28 carcass, 1-day adult    5 carcass, 4-day adult    6 carcass, 20-day adult    6 ovary, virgin 4-day female    40 ovary, mated 4-day female    29 testis, mated 4-day male    8 accessory gland, mated 4-day male    6 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (32) central nervous system, larvae L3    12 central nervous system, pupae P8    14 head, virgin 1-day female    8 head, virgin 4-day female    6 head, virgin 20-day female    8 head, mated 1-day female    6 head, mated 4-day female    7 head, mated 20-day female    6 head, mated 1-day male    10 head, mated 4-day male    10 head, mated 20-day male    14 salivary gland, larvae L3 wandering    5 salivary gland, white prepupae    10 digestive system, larvae L3 wandering    4 digestive system, 1-day adult    2 digestive system, 4-day adult    3 digestive system, 20-day adult    3 fat body, larvae L3 wandering    3 fat body, white prepupae    8 fat body, pupae P8    11 carcass, larvae L3 wandering  (28) carcass, 1-day adult    5 carcass, 4-day adult    6 carcass, 20-day adult    6 ovary, virgin 4-day female  (40) ovary, mated 4-day female  (29) testis, mated 4-day male    8 accessory gland, mated 4-day male    6 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    32 central nervous system, larvae L3    12 central nervous system, pupae P8    14 head, virgin 1-day female    8 head, virgin 4-day female    6 head, virgin 20-day female    8 head, mated 1-day female    6 head, mated 4-day female    7 head, mated 20-day female    6 head, mated 1-day male    10 head, mated 4-day male    10 head, mated 20-day male    14 salivary gland, larvae L3 wandering    5 salivary gland, white prepupae    10 digestive system, larvae L3 wandering    4 digestive system, 1-day adult    2 digestive system, 4-day adult    3 digestive system, 20-day adult    3 fat body, larvae L3 wandering    3 fat body, white prepupae    8 fat body, pupae P8    11 carcass, larvae L3 wandering    28 carcass, 1-day adult    5 carcass, 4-day adult    6 carcass, 20-day adult    6 ovary, virgin 4-day female    40 ovary, mated 4-day female    29 testis, mated 4-day male    8 accessory gland, mated 4-day male    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    32 central nervous system, larvae L3    12 central nervous system, pupae P8    14 head, virgin 1-day female    8 head, virgin 4-day female    6 head, virgin 20-day female    8 head, mated 1-day female    6 head, mated 4-day female    7 head, mated 20-day female    6 head, mated 1-day male    10 head, mated 4-day male    10 head, mated 20-day male    14 salivary gland, larvae L3 wandering    5 salivary gland, white prepupae    10 digestive system, larvae L3 wandering    4 digestive system, 1-day adult    2 digestive system, 4-day adult    3 digestive system, 20-day adult    3 fat body, larvae L3 wandering    3 fat body, white prepupae    8 fat body, pupae P8    11 carcass, larvae L3 wandering    28 carcass, 1-day adult    5 carcass, 4-day adult    6 carcass, 20-day adult    6 ovary, virgin 4-day female    40 ovary, mated 4-day female    29 testis, mated 4-day male    8 accessory gland, mated 4-day male    6 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    32 central nervous system, larvae L3    12 central nervous system, pupae P8    14 head, virgin 1-day female    8 head, virgin 4-day female    6 head, virgin 20-day female    8 head, mated 1-day female    6 head, mated 4-day female    7 head, mated 20-day female    6 head, mated 1-day male    10 head, mated 4-day male    10 head, mated 20-day male    14 salivary gland, larvae L3 wandering    5 salivary gland, white prepupae    10 digestive system, larvae L3 wandering    4 digestive system, 1-day adult    2 digestive system, 4-day adult    3 digestive system, 20-day adult    3 fat body, larvae L3 wandering    3 fat body, white prepupae    8 fat body, pupae P8    11 carcass, larvae L3 wandering    28 carcass, 1-day adult    5 carcass, 4-day adult    6 carcass, 20-day adult    6 ovary, virgin 4-day female    40 ovary, mated 4-day female    29 testis, mated 4-day male    8 accessory gland, mated 4-day male    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  32 central nervous system, larvae L3    12 central nervous system, pupae P8    14 head, virgin 1-day female    8 head, virgin 4-day female    6 head, virgin 20-day female    8 head, mated 1-day female    6 head, mated 4-day female    7 head, mated 20-day female    6 head, mated 1-day male    10 head, mated 4-day male    10 head, mated 20-day male    14 salivary gland, larvae L3 wandering    5 salivary gland, white prepupae    10 digestive system, larvae L3 wandering    4 digestive system, 1-day adult    2 digestive system, 4-day adult    3 digestive system, 20-day adult    3 fat body, larvae L3 wandering    3 fat body, white prepupae    8 fat body, pupae P8    11 carcass, larvae L3 wandering  28 carcass, 1-day adult    5 carcass, 4-day adult    6 carcass, 20-day adult    6 ovary, virgin 4-day female  (40) ovary, mated 4-day female  29 testis, mated 4-day male    8 accessory gland, mated 4-day male    6 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    32 central nervous system, larvae L3    12 central nervous system, pupae P8    14 head, virgin 1-day female    8 head, virgin 4-day female    6 head, virgin 20-day female    8 head, mated 1-day female    6 head, mated 4-day female    7 head, mated 20-day female    6 head, mated 1-day male    10 head, mated 4-day male    10 head, mated 20-day male    14 salivary gland, larvae L3 wandering    5 salivary gland, white prepupae    10 digestive system, larvae L3 wandering    4 digestive system, 1-day adult    2 digestive system, 4-day adult    3 digestive system, 20-day adult    3 fat body, larvae L3 wandering    3 fat body, white prepupae    8 fat body, pupae P8    11 carcass, larvae L3 wandering    28 carcass, 1-day adult    5 carcass, 4-day adult    6 carcass, 20-day adult    6 ovary, virgin 4-day female    40 ovary, mated 4-day female    29 testis, mated 4-day male    8 accessory gland, mated 4-day male    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    32 central nervous system, larvae L3    12 central nervous system, pupae P8    14 head, virgin 1-day female    8 head, virgin 4-day female    6 head, virgin 20-day female    8 head, mated 1-day female    6 head, mated 4-day female    7 head, mated 20-day female    6 head, mated 1-day male    10 head, mated 4-day male    10 head, mated 20-day male    14 salivary gland, larvae L3 wandering    5 salivary gland, white prepupae    10 digestive system, larvae L3 wandering    4 digestive system, 1-day adult    2 digestive system, 4-day adult    3 digestive system, 20-day adult    3 fat body, larvae L3 wandering    3 fat body, white prepupae    8 fat body, pupae P8    11 carcass, larvae L3 wandering    28 carcass, 1-day adult    5 carcass, 4-day adult    6 carcass, 20-day adult    6 ovary, virgin 4-day female    40 ovary, mated 4-day female    29 testis, mated 4-day male    8 accessory gland, mated 4-day male    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    47 embryo 02-04hr    22 embryo 04-06hr    62 embryo 06-08hr    115 embryo 08-10hr    123 embryo 10-12hr    102 embryo 12-14hr    107 embryo 14-16hr    68 embryo 16-18hr    49 embryo 18-20hr    37 embryo 20-22hr    22 embryo 22-24hr    26 larva L1    24 larva L2    15 larva L3 12hr old    12 larva L3 puffstage 1-2    14 larva L3 puffstage 3-6    27 larva L3 puffstage 7-9    39 white prepupae new    40 white prepupae 12hr    33 white prepupae 24hr    51 pupae 2d postWPP    43 pupae 3d postWPP    35 pupae 4d postWPP    10 adult male 01day    13 adult male 05day    15 adult male 30day    16 adult female 01day    19 adult female 05day    37 adult female 30day    35 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (47) embryo 02-04hr    22 embryo 04-06hr  (62) embryo 06-08hr  (115) embryo 08-10hr  (123) embryo 10-12hr  (102) embryo 12-14hr  (107) embryo 14-16hr  (68) embryo 16-18hr  (49) embryo 18-20hr  (37) embryo 20-22hr    22 embryo 22-24hr  26 larva L1    24 larva L2    15 larva L3 12hr old    12 larva L3 puffstage 1-2    14 larva L3 puffstage 3-6  (27) larva L3 puffstage 7-9  (39) white prepupae new  (40) white prepupae 12hr  (33) white prepupae 24hr  (51) pupae 2d postWPP  (43) pupae 3d postWPP  (35) pupae 4d postWPP    10 adult male 01day    13 adult male 05day    15 adult male 30day    16 adult female 01day    19 adult female 05day  (37) adult female 30day  (35) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    47 embryo 02-04hr    22 embryo 04-06hr    62 embryo 06-08hr  (115) embryo 08-10hr  (123) embryo 10-12hr  102 embryo 12-14hr  107 embryo 14-16hr    68 embryo 16-18hr    49 embryo 18-20hr    37 embryo 20-22hr    22 embryo 22-24hr    26 larva L1    24 larva L2    15 larva L3 12hr old    12 larva L3 puffstage 1-2    14 larva L3 puffstage 3-6    27 larva L3 puffstage 7-9    39 white prepupae new    40 white prepupae 12hr    33 white prepupae 24hr    51 pupae 2d postWPP    43 pupae 3d postWPP    35 pupae 4d postWPP    10 adult male 01day    13 adult male 05day    15 adult male 30day    16 adult female 01day    19 adult female 05day    37 adult female 30day    35 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    47 embryo 02-04hr    22 embryo 04-06hr    62 embryo 06-08hr    115 embryo 08-10hr    123 embryo 10-12hr    102 embryo 12-14hr    107 embryo 14-16hr    68 embryo 16-18hr    49 embryo 18-20hr    37 embryo 20-22hr    22 embryo 22-24hr    26 larva L1    24 larva L2    15 larva L3 12hr old    12 larva L3 puffstage 1-2    14 larva L3 puffstage 3-6    27 larva L3 puffstage 7-9    39 white prepupae new    40 white prepupae 12hr    33 white prepupae 24hr    51 pupae 2d postWPP    43 pupae 3d postWPP    35 pupae 4d postWPP    10 adult male 01day    13 adult male 05day    15 adult male 30day    16 adult female 01day    19 adult female 05day    37 adult female 30day    35 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    47 embryo 02-04hr    22 embryo 04-06hr    62 embryo 06-08hr    115 embryo 08-10hr    123 embryo 10-12hr    102 embryo 12-14hr    107 embryo 14-16hr    68 embryo 16-18hr    49 embryo 18-20hr    37 embryo 20-22hr    22 embryo 22-24hr    26 larva L1    24 larva L2    15 larva L3 12hr old    12 larva L3 puffstage 1-2    14 larva L3 puffstage 3-6    27 larva L3 puffstage 7-9    39 white prepupae new    40 white prepupae 12hr    33 white prepupae 24hr    51 pupae 2d postWPP    43 pupae 3d postWPP    35 pupae 4d postWPP    10 adult male 01day    13 adult male 05day    15 adult male 30day    16 adult female 01day    19 adult female 05day    37 adult female 30day    35 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (47) embryo 02-04hr    22 embryo 04-06hr  (62) embryo 06-08hr  (115) embryo 08-10hr  (123) embryo 10-12hr  (102) embryo 12-14hr  (107) embryo 14-16hr  (68) embryo 16-18hr  (49) embryo 18-20hr  (37) embryo 20-22hr    22 embryo 22-24hr  26 larva L1    24 larva L2    15 larva L3 12hr old    12 larva L3 puffstage 1-2    14 larva L3 puffstage 3-6  27 larva L3 puffstage 7-9  (39) white prepupae new  (40) white prepupae 12hr  (33) white prepupae 24hr  (51) pupae 2d postWPP  (43) pupae 3d postWPP  (35) pupae 4d postWPP    10 adult male 01day    13 adult male 05day    15 adult male 30day    16 adult female 01day    19 adult female 05day  (37) adult female 30day  (35) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    47 embryo 02-04hr    22 embryo 04-06hr    62 embryo 06-08hr  115 embryo 08-10hr  123 embryo 10-12hr  102 embryo 12-14hr  107 embryo 14-16hr    68 embryo 16-18hr    49 embryo 18-20hr    37 embryo 20-22hr    22 embryo 22-24hr    26 larva L1    24 larva L2    15 larva L3 12hr old    12 larva L3 puffstage 1-2    14 larva L3 puffstage 3-6    27 larva L3 puffstage 7-9    39 white prepupae new    40 white prepupae 12hr    33 white prepupae 24hr    51 pupae 2d postWPP    43 pupae 3d postWPP    35 pupae 4d postWPP    10 adult male 01day    13 adult male 05day    15 adult male 30day    16 adult female 01day    19 adult female 05day    37 adult female 30day    35 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    47 embryo 02-04hr    22 embryo 04-06hr    62 embryo 06-08hr    115 embryo 08-10hr    123 embryo 10-12hr    102 embryo 12-14hr    107 embryo 14-16hr    68 embryo 16-18hr    49 embryo 18-20hr    37 embryo 20-22hr    22 embryo 22-24hr    26 larva L1    24 larva L2    15 larva L3 12hr old    12 larva L3 puffstage 1-2    14 larva L3 puffstage 3-6    27 larva L3 puffstage 7-9    39 white prepupae new    40 white prepupae 12hr    33 white prepupae 24hr    51 pupae 2d postWPP    43 pupae 3d postWPP    35 pupae 4d postWPP    10 adult male 01day    13 adult male 05day    15 adult male 30day    16 adult female 01day    19 adult female 05day    37 adult female 30day    35 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    13 Schneider line 2 Sg4    7 embryonic 1182-4H    22 embryonic GM2    16 embryonic Kc167    10 embryonic S1    34 embryonic S3    6 leg disc CME L1    9 wing disc CME-W2    15 wing disc ML-DmD8    18 wing disc ML-DmD9    12 wing disc ML-DmD16-c3    18 wing disc ML-DmD21    9 wing disc ML-DmD32    75 haltere disc ML-DmD17-c3    37 eye-antennal disc ML-DmD11    11 antennal disc ML-DmD20-c5    9 mixed discs ML-DmD4-c1    13 CNS ML-DmBG1-c1    11 CNS ML-DmBG2-c2    42 tumorous blood cells mbn2    17 ovary fGS/OSS    6 ovary OSC    7 ovary OSS    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    13 Schneider line 2 Sg4    7 embryonic 1182-4H    22 embryonic GM2    16 embryonic Kc167    10 embryonic S1  (34) embryonic S3    6 leg disc CME L1    9 wing disc CME-W2    15 wing disc ML-DmD8    18 wing disc ML-DmD9    12 wing disc ML-DmD16-c3    18 wing disc ML-DmD21    9 wing disc ML-DmD32  (75) haltere disc ML-DmD17-c3  (37) eye-antennal disc ML-DmD11    11 antennal disc ML-DmD20-c5    9 mixed discs ML-DmD4-c1    13 CNS ML-DmBG1-c1    11 CNS ML-DmBG2-c2  (42) tumorous blood cells mbn2    17 ovary fGS/OSS    6 ovary OSC    7 ovary OSS    9 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    13 Schneider line 2 Sg4    7 embryonic 1182-4H    22 embryonic GM2    16 embryonic Kc167    10 embryonic S1    34 embryonic S3    6 leg disc CME L1    9 wing disc CME-W2    15 wing disc ML-DmD8    18 wing disc ML-DmD9    12 wing disc ML-DmD16-c3    18 wing disc ML-DmD21    9 wing disc ML-DmD32    75 haltere disc ML-DmD17-c3    37 eye-antennal disc ML-DmD11    11 antennal disc ML-DmD20-c5    9 mixed discs ML-DmD4-c1    13 CNS ML-DmBG1-c1    11 CNS ML-DmBG2-c2    42 tumorous blood cells mbn2    17 ovary fGS/OSS    6 ovary OSC    7 ovary OSS    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    13 Schneider line 2 Sg4    7 embryonic 1182-4H    22 embryonic GM2    16 embryonic Kc167    10 embryonic S1    34 embryonic S3    6 leg disc CME L1    9 wing disc CME-W2    15 wing disc ML-DmD8    18 wing disc ML-DmD9    12 wing disc ML-DmD16-c3    18 wing disc ML-DmD21    9 wing disc ML-DmD32    75 haltere disc ML-DmD17-c3    37 eye-antennal disc ML-DmD11    11 antennal disc ML-DmD20-c5    9 mixed discs ML-DmD4-c1    13 CNS ML-DmBG1-c1    11 CNS ML-DmBG2-c2    42 tumorous blood cells mbn2    17 ovary fGS/OSS    6 ovary OSC    7 ovary OSS    9 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    13 Schneider line 2 Sg4    7 embryonic 1182-4H    22 embryonic GM2    16 embryonic Kc167    10 embryonic S1    34 embryonic S3    6 leg disc CME L1    9 wing disc CME-W2    15 wing disc ML-DmD8    18 wing disc ML-DmD9    12 wing disc ML-DmD16-c3    18 wing disc ML-DmD21    9 wing disc ML-DmD32    75 haltere disc ML-DmD17-c3    37 eye-antennal disc ML-DmD11    11 antennal disc ML-DmD20-c5    9 mixed discs ML-DmD4-c1    13 CNS ML-DmBG1-c1    11 CNS ML-DmBG2-c2    42 tumorous blood cells mbn2    17 ovary fGS/OSS    6 ovary OSC    7 ovary OSS    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    13 Schneider line 2 Sg4    7 embryonic 1182-4H    22 embryonic GM2    16 embryonic Kc167    10 embryonic S1  (34) embryonic S3    6 leg disc CME L1    9 wing disc CME-W2    15 wing disc ML-DmD8    18 wing disc ML-DmD9    12 wing disc ML-DmD16-c3    18 wing disc ML-DmD21    9 wing disc ML-DmD32  (75) haltere disc ML-DmD17-c3  (37) eye-antennal disc ML-DmD11    11 antennal disc ML-DmD20-c5    9 mixed discs ML-DmD4-c1    13 CNS ML-DmBG1-c1    11 CNS ML-DmBG2-c2  (42) tumorous blood cells mbn2    17 ovary fGS/OSS    6 ovary OSC    7 ovary OSS    9 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    13 Schneider line 2 Sg4    7 embryonic 1182-4H    22 embryonic GM2    16 embryonic Kc167    10 embryonic S1    34 embryonic S3    6 leg disc CME L1    9 wing disc CME-W2    15 wing disc ML-DmD8    18 wing disc ML-DmD9    12 wing disc ML-DmD16-c3    18 wing disc ML-DmD21    9 wing disc ML-DmD32    75 haltere disc ML-DmD17-c3    37 eye-antennal disc ML-DmD11    11 antennal disc ML-DmD20-c5    9 mixed discs ML-DmD4-c1    13 CNS ML-DmBG1-c1    11 CNS ML-DmBG2-c2    42 tumorous blood cells mbn2    17 ovary fGS/OSS    6 ovary OSC    7 ovary OSS    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    13 Schneider line 2 Sg4    7 embryonic 1182-4H    22 embryonic GM2    16 embryonic Kc167    10 embryonic S1    34 embryonic S3    6 leg disc CME L1    9 wing disc CME-W2    15 wing disc ML-DmD8    18 wing disc ML-DmD9    12 wing disc ML-DmD16-c3    18 wing disc ML-DmD21    9 wing disc ML-DmD32    75 haltere disc ML-DmD17-c3    37 eye-antennal disc ML-DmD11    11 antennal disc ML-DmD20-c5    9 mixed discs ML-DmD4-c1    13 CNS ML-DmBG1-c1    11 CNS ML-DmBG2-c2    42 tumorous blood cells mbn2    17 ovary fGS/OSS    6 ovary OSC    7 ovary OSS    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    7 cold shock, 4-day adult    5 heat shock, 4-day adult    12 Cadmium 50 mM 6 hrs, larvae L3    6 Cadmium 50 mM 12 hrs, larvae L3    10 Cadmium 50 mM 48 hrs, 4-day adult    11 Cadmium 100 mM 48 hrs, 4-day adult    20 Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult    14 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    6 Ethanol 2.5% 3 hrs, larvae L3    24 Ethanol 5% 3 hrs, larvae L3    8 Ethanol 10% 3 hrs, larvae L3    6 Caffeine 1.5 mg/ml 4 hrs, larvae L3    9 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    17 Caffeine 25 mg/ml 48 hrs, 4-day adult    7 Paraquat 5 mM 48 hrs, 4-day adult    16 Paraquat 10 mM 48 hrs, 4-day adult    18 Rotenone 2 μg 12 hrs, larvae L3    6 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    7 cold shock, 4-day adult    5 heat shock, 4-day adult    12 Cadmium 50 mM 6 hrs, larvae L3    6 Cadmium 50 mM 12 hrs, larvae L3    10 Cadmium 50 mM 48 hrs, 4-day adult    11 Cadmium 100 mM 48 hrs, 4-day adult    20 Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult    14 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    6 Ethanol 2.5% 3 hrs, larvae L3    24 Ethanol 5% 3 hrs, larvae L3    8 Ethanol 10% 3 hrs, larvae L3    6 Caffeine 1.5 mg/ml 4 hrs, larvae L3    9 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    17 Caffeine 25 mg/ml 48 hrs, 4-day adult    7 Paraquat 5 mM 48 hrs, 4-day adult    16 Paraquat 10 mM 48 hrs, 4-day adult    18 Rotenone 2 μg 12 hrs, larvae L3    6 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    7 cold shock, 4-day adult    5 heat shock, 4-day adult    12 Cadmium 50 mM 6 hrs, larvae L3    6 Cadmium 50 mM 12 hrs, larvae L3    10 Cadmium 50 mM 48 hrs, 4-day adult    11 Cadmium 100 mM 48 hrs, 4-day adult    20 Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult    14 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    6 Ethanol 2.5% 3 hrs, larvae L3    24 Ethanol 5% 3 hrs, larvae L3    8 Ethanol 10% 3 hrs, larvae L3    6 Caffeine 1.5 mg/ml 4 hrs, larvae L3    9 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    17 Caffeine 25 mg/ml 48 hrs, 4-day adult    7 Paraquat 5 mM 48 hrs, 4-day adult    16 Paraquat 10 mM 48 hrs, 4-day adult    18 Rotenone 2 μg 12 hrs, larvae L3    6 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    7 cold shock, 4-day adult    5 heat shock, 4-day adult    12 Cadmium 50 mM 6 hrs, larvae L3    6 Cadmium 50 mM 12 hrs, larvae L3    10 Cadmium 50 mM 48 hrs, 4-day adult    11 Cadmium 100 mM 48 hrs, 4-day adult    20 Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult    14 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    6 Ethanol 2.5% 3 hrs, larvae L3    24 Ethanol 5% 3 hrs, larvae L3    8 Ethanol 10% 3 hrs, larvae L3    6 Caffeine 1.5 mg/ml 4 hrs, larvae L3    9 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    17 Caffeine 25 mg/ml 48 hrs, 4-day adult    7 Paraquat 5 mM 48 hrs, 4-day adult    16 Paraquat 10 mM 48 hrs, 4-day adult    18 Rotenone 2 μg 12 hrs, larvae L3    6 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    7 cold shock, 4-day adult    5 heat shock, 4-day adult    12 Cadmium 50 mM 6 hrs, larvae L3    6 Cadmium 50 mM 12 hrs, larvae L3    10 Cadmium 50 mM 48 hrs, 4-day adult    11 Cadmium 100 mM 48 hrs, 4-day adult    20 Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult    14 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    6 Ethanol 2.5% 3 hrs, larvae L3    24 Ethanol 5% 3 hrs, larvae L3    8 Ethanol 10% 3 hrs, larvae L3    6 Caffeine 1.5 mg/ml 4 hrs, larvae L3    9 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    17 Caffeine 25 mg/ml 48 hrs, 4-day adult    7 Paraquat 5 mM 48 hrs, 4-day adult    16 Paraquat 10 mM 48 hrs, 4-day adult    18 Rotenone 2 μg 12 hrs, larvae L3    6 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    7 cold shock, 4-day adult    5 heat shock, 4-day adult    12 Cadmium 50 mM 6 hrs, larvae L3    6 Cadmium 50 mM 12 hrs, larvae L3    10 Cadmium 50 mM 48 hrs, 4-day adult    11 Cadmium 100 mM 48 hrs, 4-day adult    20 Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult    14 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    6 Ethanol 2.5% 3 hrs, larvae L3    24 Ethanol 5% 3 hrs, larvae L3    8 Ethanol 10% 3 hrs, larvae L3    6 Caffeine 1.5 mg/ml 4 hrs, larvae L3    9 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    17 Caffeine 25 mg/ml 48 hrs, 4-day adult    7 Paraquat 5 mM 48 hrs, 4-day adult    16 Paraquat 10 mM 48 hrs, 4-day adult    18 Rotenone 2 μg 12 hrs, larvae L3    6 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    7 cold shock, 4-day adult    5 heat shock, 4-day adult    12 Cadmium 50 mM 6 hrs, larvae L3    6 Cadmium 50 mM 12 hrs, larvae L3    10 Cadmium 50 mM 48 hrs, 4-day adult    11 Cadmium 100 mM 48 hrs, 4-day adult    20 Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult    14 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    6 Ethanol 2.5% 3 hrs, larvae L3    24 Ethanol 5% 3 hrs, larvae L3    8 Ethanol 10% 3 hrs, larvae L3    6 Caffeine 1.5 mg/ml 4 hrs, larvae L3    9 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    17 Caffeine 25 mg/ml 48 hrs, 4-day adult    7 Paraquat 5 mM 48 hrs, 4-day adult    16 Paraquat 10 mM 48 hrs, 4-day adult    18 Rotenone 2 μg 12 hrs, larvae L3    6 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    7 cold shock, 4-day adult    5 heat shock, 4-day adult    12 Cadmium 50 mM 6 hrs, larvae L3    6 Cadmium 50 mM 12 hrs, larvae L3    10 Cadmium 50 mM 48 hrs, 4-day adult    11 Cadmium 100 mM 48 hrs, 4-day adult    20 Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult    14 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    6 Ethanol 2.5% 3 hrs, larvae L3    24 Ethanol 5% 3 hrs, larvae L3    8 Ethanol 10% 3 hrs, larvae L3    6 Caffeine 1.5 mg/ml 4 hrs, larvae L3    9 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    17 Caffeine 25 mg/ml 48 hrs, 4-day adult    7 Paraquat 5 mM 48 hrs, 4-day adult    16 Paraquat 10 mM 48 hrs, 4-day adult    18 Rotenone 2 μg 12 hrs, larvae L3    6 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_30 mE1_20_mRNA_expression_cluster_03
External Data & Images
Linkouts
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele partially lethal - majority die | pupal stage, with Scer\GAL4pnr-MD237 McrGD988 Other Phenotypes Allele visible, with Scer\GAL4pnr-MD237 McrGD988 Phenotype manifest in Allele chaeta, with Scer\GAL4pnr-MD237 McrGD988 trichogen cell, with Scer\GAL4pnr-MD237 McrGD988
Classical Alleles ( 3 )
For All Classical Alleles Show
Allele of Mcr Class Mutagen Stocks Known lesion McrEY07421 P-element activity 2 -- McrCB-6141-3 1 -- Mcrf03851 piggyBac transposase 1 --
Alleles Carried on Transgenic Constructs ( 2 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Mcr Class Mutagen Stocks Known lesion McrGD988 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes McrKK104742 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes
Aneuploid Aberrations
Disrupted in	Df(2L)Exel7034 (Ryder, 2004.4.26) Df(2L)Trf-C6R31 (Crowley et al., 1993)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD988} NA P{KK104742} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EPgy2}McrEY07421 NA miscellaneous insertions P{RS3}McrCB-6141-3 NA PBac{WH}Mcrf03851 NA
Gene Ontology: Function, Process & Cellular Component ( 8 unique terms )
Terms Based on Experimental Evidence ( 6 terms )
Molecular Function
CV term Evidence References
eukaryotic cell surface binding inferred from direct assay (Stroschein-Stevenson et al., 2006) protein binding inferred from physical interaction with egg (Stabell et al., 2006)
Biological Process
CV term Evidence References
antibacterial humoral response inferred from direct assay (Lagueux et al., 2000) lateral inhibition inferred from mutant phenotype (Mummery-Widmer et al., 2009) phagocytosis, engulfment inferred from mutant phenotype (Stroschein-Stevenson et al., 2006) response to yeast inferred from mutant phenotype (Stroschein-Stevenson et al., 2006)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 2 terms )
Molecular Function
CV term Evidence References
endopeptidase inhibitor activity inferred from sequence or structural similarity with UniProtKB:P14046 (FlyBase, 1992-)
Biological Process ( 0 terms)
Cellular Component
CV term Evidence References
extracellular space inferred from electronic annotation with InterPro:IPR011626 (FlyBase Curators et al., 2004-)
Sequence Ontology: Class of Gene
	gene (Waterhouse et al., 2007) nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
Mcr - ALiX anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Mcr - Arp10 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Mcr - Arpc4 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Mcr - CG10839 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Mcr - CG12883 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Mcr - CG13321 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Mcr - CG14153 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Mcr - CG15661 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Mcr - CG15784 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Mcr - CG1688 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Mcr - CG1971 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Mcr - CG2211 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Mcr - CG3303 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Mcr - CG5027 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Mcr - CG5888 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Mcr - CG5934 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Mcr - CtBP anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Mcr - Hcs anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Mcr - Hsc70-1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Mcr - ImpL3 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Mcr - LRP1 experimental knowledge based (Guruharsha et al., 2011) Mcr - Nmdar1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Mcr - Nnf1b anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Mcr - PCID2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Mcr - Pnn anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Mcr - Rab7 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Mcr - RpS21 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Mcr - Syx8 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Mcr - Tango4 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Mcr - WASp anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Mcr - cbx anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Mcr - endoB anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Mcr - gro anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Mcr - hep anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Mcr - kst anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Mcr - morgue anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Mcr - mub anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Mcr - p130CAS anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Mcr - ppa anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Mcr - roq anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Mcr - stv anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Mcr - vps2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Mcr - α-Spec anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Mcr allele Gene References
External Data
Linkouts
Orthologs
OrthoDB Orthologs (32) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6Q597Q Dipteran inclusive ortholog search EOG67M25S Insect inclusive ortholog search EOG67SR8K Arthropod inclusive ortholog search EOG6X95Z0 Metazoa inclusive ortholog search No orthologs identified
Orthologs in Drosophila Species (EOG6Q597Q)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Mcr     Drosophila simulans   Dsim\Tep6 Y   Drosophila sechellia   Dsec\Tep6 Y   Drosophila erecta   Dere\Tep6 Y   Drosophila yakuba   Dyak\Tep6 Y   Drosophila ananassae   Dana\Tep6 Y   Drosophila pseudoobscura pseudoobscura   Dpse\Tep6 Y   Drosophila persimilis   Dper\Tep6 Y   Drosophila willistoni   Dwil\Tep6 Y   Drosophila virilis   Dvir\Tep6 Y   Drosophila mojavensis   Dmoj\Tep6 Y   Drosophila grimshawi   Dgri\Tep6 Y
Orthologs in non-Drosophila Dipterans (EOG67M25S)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL012267   Anopheles gambiae Malaria mosquito  Agam\TEP13
Orthologs in non-Dipteran Insects (EOG67SR8K)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\TEPA   Apis mellifera Western honey bee  Amel\GB53760   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG001033   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH11882   Atta cephalotes Leafcutter ant  Acep\ACEP23569   Camponotus floridanus Florida carpenter ant  Cflo\CFLO18388   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL23318   Linepithema humile Argentine ant  Lhum\LH24313   Pogonomyrmex barbatus Red harvester ant  Pbar\PB12837   Solenopsis invicta Red fire ant  Sinv\SINV10278   Acyrthosiphon pisum Pea aphid  Apim\ACYPI010045   Bombyx mori Silkmoth  Bmor\BGIBMGA004193   Bombyx mori Silkmoth  Bmor\BGIBMGA004536   Pediculus humanus Human body louse  Phum\PHUM289860   Tribolium castaneum Red flour beetle  Tcas\TC009375
Orthologs in non-Insect Arthropods (EOG6X95Z0)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\gltA   Ixodes scapularis Deer tick  Isca\ISCW003090   Ixodes scapularis Deer tick  Isca\ISCW003089
Orthologs in non-Arthropod Metazoa (None identified)
No non-Arthropod Metazoa orthologies identified
Human Orthologs (0)
Gene OMIM HGNC
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\Tep6 Drosophila sechellia Dsec\Tep6 Drosophila erecta Dere\Tep6 Drosophila yakuba Dyak\Tep6 Drosophila ananassae Dana\Tep6 Drosophila pseudoobscura pseudoobscura Dpse\Tep6 Drosophila persimilis Dper\Tep6 Drosophila willistoni Dwil\Tep6 Drosophila virilis Dvir\Tep6 Drosophila mojavensis Dmoj\Tep6 Drosophila grimshawi Dgri\Tep6
Stocks & Reagents
Stocks Listed in FlyBase ( 6 )
Bloomington	15997 y1 w67c23; P{EPgy2}McrEY07421/CyO
Harvard	- PBac{WH}Mcrf03851
Kyoto	123945 w1118; P{RS3}McrCB-6141-3 111715 yd2 w1118 P{ey-FLP.N}2 P{GMR-lacZ.C(38.1)}TPN1; P{EPgy2}McrEY07421 P{neoFRT}40A/CyO y+
VDRC	v100197 P{KK104742}VIE-260B v2785 w1118; P{GD988}v2785
Genomic Clones ( 1 )
	BACR08I01 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 94 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD23292
Other clones	DPiM_LD23292
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	LD19832 RE28333 RE34749 RE51963 RE55317
Other clones	20134 33123 35285 43318 50309 52178 55472 65298 72040 75130 83215 103864 144565 164957 173328 174363 190716 274553 AT12914 CK01.7B.F6 CK01.59A.B6 CK01.78A.E1 CK01.85B.E2 CK01.101C.A8 CK01.103D.D12 CK01.103D.E1 Dmel_dig_010074_0638_2186 Dmel_neb_013567_0596_3144 EC33959 EK010455 EK032512 EK047830 EK067549 EK079448 EK085725 EK101301 EK133864 EK142855 EK146425 EK166764 EK174441 EK176324 EK182118 EK200314 EK206029 EK216819 EK250247 EK257904 EK270645 EK275741 EK277554 EK293045 EK302441 FGM312D07 LD16028 LD27113 RC0-DL0001-140700-215-A12 RP003002934 RP003021770 RP003022797 RP003040161 RP003087103 RP003097473 RP003129722 RP003136976 RP003150935 RP003169924 RP003193088 RP003234787 RP003260756 RP003275225 RP003304651 RP003305594 RP003332974 RP003343449 RP003345600 RP003356165 RP003359796 RP003426102 RP003438842 RP003441477 RP003480282 RP003493537 RP003510639 RP003564728 RP003605921 RP003674161
RNAi & Array Information
Linkouts
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: Mcr CG7586 (Bayraktaroglu, 2000.4.3)
Additional comments
Other Comments
	S2 cells treated with dsRNA generated against this gene show reduced phagocytosis of Candida albicans compared to untreated cells. However, the dsRNA treatment does not affect phagocytosis of either Escherichia coli, Staphylococcus aureus or latex beads. (Stroschein-Stevenson et al., 2006) Transcription unit defined as part of a molecular analysis of Trf. (Crowley et al., 1993) P-element insertions P{lacW}Trf1 and P{lacW}Trf2 (which lie within 50bp of each other at 28D--28E) map approximately 3kb proximal to 3' end of Mcr transcription unit. (Crowley et al., 1993)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_079949 RefSeq (Proteins) • NP_524688 DDBJ / EMBL / GenBank • AA940947 AAF52601 AAL13755 AW942672 AY058526 CZ486447 CZ486448 Y11116 Entrez Gene - A searchable database of RefSeq genes. • 44071 UniProtKB/TrEMBL • Q9VLT3
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Low-density lipoprotein (LDL) receptor class A repeat (IPR002172) Alpha-2-macroglobulin, N-terminal (IPR002890) Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid (IPR008930) Alpha-macroglobulin, receptor-binding (IPR009048) Alpha-2-macroglobulin, N-terminal 2 (IPR011625) A-macroglobulin complement component (IPR011626) Alpha-2-macroglobulin (IPR001599)
Linkouts
Synonyms & Secondary IDs ( 16 )
Reported As
Symbol Synonym	anon-28DE   CG7586 (Anholt and Mackay, 2001, Stabell et al., 2006, Schiess et al., 2009, Keleman et al., 2009.8.5) DmTEP6 (Bou Aoun et al., 2011) dTEPVI (Lagueux, 2000.3.15, Lagueux et al., 2000) Mcr (Anonymous, 2006, Stroschein-Stevenson et al., 2006, Bou Aoun et al., 2008, Mudiganti et al., 2010, Choksi et al., 2006) mcr (Guenin et al., 2010) Tep6 (Bou Aoun et al., 2011, Bou Aoun et al., 2008, Waterhouse et al., 2007, ) TEP6 (Bou Aoun et al., 2011) TEP6mel (Bou Aoun et al., 2011) TepVI (Christophides et al., 2002) α-2-Mrp
Name Synonym	Macroglobulin complement-related (Crowley, 1997.7.14, ) Macroglobulin complement related (Anonymous, 2006) TEP (Erturk-Hasdemir and Silverman, 2005) Tep6   Thiolester containing protein VI (Lagueux et al., 2000) α-2-macroglobulin related
Secondary FlyBase IDs
	FBgn0014086 FBgn0020240 FBgn0031984 FBgn0041178 FBgn0087010
References ( 44 )
Generate a list of	All references relating to this gene ( 44 )
List References by type	Research paper  ( 16 ) Supplementary material  ( 6 ) Review  ( 2 ) Personal communication to FlyBase  ( 11 ) Abstract  ( 2 ) FlyBase analysis  ( 2 ) DNA/RNA sequence record  ( 1 ) Letter  ( 1 ) Curated genome annotation  ( 2 )
Recent research papers ( 2 )
	Baycin-Hizal et al., 2011, J. Proteome Res. 10(6): 2777--2784 GlycoFly: A Database of Drosophila N-linked Glycoproteins Identified Using SPEG-MS Techniques. [FBrf0213834] Bou Aoun et al., 2011, J. Innate Immun. 3(1): 52--64 Analysis of thioester-containing proteins during the innate immune response of Drosophila melanogaster. [FBrf0212631] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...