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Gene Dmel\pHCl

General Information
Symbol	Dmel\pHCl	Species	D. melanogaster
Name		Annotation symbol	CG44099
Feature type	protein_coding_gene	FlyBase ID	FBgn0264908
Gene Model Status	Current	Stock availability	14 publicly available
Also Known As	CG33989
Genomic Location
Chromosome (arm)	3L	Recombination map
Cytogenetic map	72A2-72A4	Sequence location	3L:15,841,678..15,892,129 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	This gene is referred to in FlyBase by the symbol Dmel\pHCl (CG44099, FBgn0264908). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: chloride channel activity. There is experimental evidence that it is involved in the biological process: neurogenesis. 14 alleles are reported. No phenotypic data is available. It has 14 annotated transcripts and 14 annotated polypeptides. Protein features are: Gamma-aminobutyric acid A receptor; Glutamate-Gated Chloride Channel; Neurotransmitter-gated ion-channel; Neurotransmitter-gated ion-channel ligand-binding; Neurotransmitter-gated ion-channel transmembrane domain. Gene sequence location is 3L:15841678..15892129.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 72A2-72A4   Limits computationally determined from genome sequence between P{EP}Tfb2EP572 and P{lacW}thj5C8&P{PZ}Mbs03802
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\pHCl for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.47 Gene merge based on EST/cDNA and BLASTX (protein alignment) data Low-frequency RNA-Seq exon junction(s) not annotated. Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters. The location of the 3 nucleotide microexon is ambiguous. There are two possible locations (AGCCCGT) in the final long intron.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) pHCl-RC FBtr0334972  NM_001038937   3361   637 pHCl-RD FBtr0334973  NM_001038934   3164   737 pHCl-RE FBtr0334974  NM_001038936   3239   762 pHCl-RF FBtr0334975  NM_001038935   3293   779 pHCl-RG FBtr0334976  NM_001169979   3687   681 pHCl-RH FBtr0334971  NM_001259852   3247   762 pHCl-RI FBtr0334970  NM_001259853   3223   754 pHCl-RJ FBtr0334977  NM_001274965   3277   772 pHCl-RK FBtr0334978  NM_001274966   3199   746 pHCl-RL FBtr0334979  NM_001274967   5941   747 pHCl-RM FBtr0334980  NM_001274968   3818   954 pHCl-RN FBtr0334981  NM_001274969   6629   978 pHCl-RO FBtr0334982  NM_001274970   3743   929 pHCl-RP FBtr0334983  NM_001274971   3218   754
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein pHCl-PC   FBpp0306985   71.5   637   7.54     NP_001034026   AAF49570 pHCl-PD   FBpp0306986   82.4   737   7.87     NP_001034023   AAF49571 pHCl-PE   FBpp0306987   85.3   762   7.83     NP_001034025   ABC66135 pHCl-PF   FBpp0306988   87.0   779   8.04     NP_001034024   ABC66136 pHCl-PG   FBpp0306989   76.5   681   7.41     NP_001163450   ACZ94721 pHCl-PH   FBpp0306984   85.3   762   7.73     NP_001246781   AFH04452 pHCl-PI   FBpp0306983   84.2   754   8.19     NP_001246782   AFH04453 pHCl-PJ   FBpp0306990   86.2   772   7.94     NP_001261894   AGB94587 pHCl-PK   FBpp0306991   83.3   746   8.19     NP_001261895   AGB94588 pHCl-PL   FBpp0306992   83.3   747   8.09     NP_001261896   AGB94589 pHCl-PM   FBpp0306993   105.5   954   7.52     NP_001261897   AGB94590 pHCl-PN   FBpp0306994   108.1   978   7.74     NP_001261898   AGB94591 pHCl-PO   FBpp0306995   102.7   929   7.76     NP_001261899   AGB94592 pHCl-PP   FBpp0306996   84.4   754   7.72     NP_001261900   AGB94593
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Glutamate-Gated Chloride Channel (IPR015680) Gamma-aminobutyric acid A receptor (IPR006028) Neurotransmitter-gated ion-channel (IPR006201) Neurotransmitter-gated ion-channel ligand-binding (IPR006202) Neurotransmitter-gated ion-channel transmembrane domain (IPR006029)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA141800   AA698162   AE014296 AAF49570   AE014296 AAF49571   AE014296 ABC66135   AE014296 ABC66136   AE014296 ACZ94721   AE014296 AFH04452   AE014296 AFH04453   AE014296 AGB94587   AE014296 AGB94588   AE014296 AGB94589   AE014296 AGB94590   AE014296 AGB94591   AE014296 AGB94592   AE014296 AGB94593   AI402520   AI513323   AW941844   AY060328 AAL25367   AY880248 AAX11175   AY880249 AAX11176   AY880250 AAX11177   BT012472   BT029267   BT122157   BT122162   CO179323   CO270583   CO273962   CO280839   CO282038   CO283786   CO289894   CO292290   CO294552   CO296179   CO304066   CO305177   CO310592   CO331955   CO339367   CO339590   CO339923   CX309455   CX309456   EC069224   EC069863   EC076917   EC079210   EC082432   EC196398   EC210741   EC212433   EC212689   EC213134   EC213447   EC217121   EC220912   EC242937   EC248101   EC260043   EL877417   EL877418   EL877494   EL877579   EL877580   GH949948   GH965746   GH969524   GH981429
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	E1JI08 Q5D6W0 Q9VUV3 Q5D6V9 Q5D6W1 Q2PDZ0 Q9VUV1 Q2PDY9 Q95T52 Q9VUV2
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    0 central nervous system, larvae L3    3 central nervous system, pupae P8    28 head, virgin 1-day female    12 head, virgin 4-day female    11 head, virgin 20-day female    4 head, mated 1-day female    10 head, mated 4-day female    8 head, mated 20-day female    4 head, mated 1-day male    14 head, mated 4-day male    14 head, mated 20-day male    9 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    4 carcass, larvae L3 wandering    1 carcass, 1-day adult    15 carcass, 4-day adult    11 carcass, 20-day adult    4 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    0 central nervous system, larvae L3    3 central nervous system, pupae P8  (28) head, virgin 1-day female    12 head, virgin 4-day female    11 head, virgin 20-day female    4 head, mated 1-day female    10 head, mated 4-day female    8 head, mated 20-day female    4 head, mated 1-day male    14 head, mated 4-day male    14 head, mated 20-day male    9 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    4 carcass, larvae L3 wandering    1 carcass, 1-day adult    15 carcass, 4-day adult    11 carcass, 20-day adult    4 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    0 central nervous system, larvae L3    3 central nervous system, pupae P8    28 head, virgin 1-day female    12 head, virgin 4-day female    11 head, virgin 20-day female    4 head, mated 1-day female    10 head, mated 4-day female    8 head, mated 20-day female    4 head, mated 1-day male    14 head, mated 4-day male    14 head, mated 20-day male    9 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    4 carcass, larvae L3 wandering    1 carcass, 1-day adult    15 carcass, 4-day adult    11 carcass, 20-day adult    4 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    0 central nervous system, larvae L3    3 central nervous system, pupae P8    28 head, virgin 1-day female    12 head, virgin 4-day female    11 head, virgin 20-day female    4 head, mated 1-day female    10 head, mated 4-day female    8 head, mated 20-day female    4 head, mated 1-day male    14 head, mated 4-day male    14 head, mated 20-day male    9 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    4 carcass, larvae L3 wandering    1 carcass, 1-day adult    15 carcass, 4-day adult    11 carcass, 20-day adult    4 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    0 central nervous system, larvae L3    3 central nervous system, pupae P8    28 head, virgin 1-day female    12 head, virgin 4-day female    11 head, virgin 20-day female    4 head, mated 1-day female    10 head, mated 4-day female    8 head, mated 20-day female    4 head, mated 1-day male    14 head, mated 4-day male    14 head, mated 20-day male    9 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    4 carcass, larvae L3 wandering    1 carcass, 1-day adult    15 carcass, 4-day adult    11 carcass, 20-day adult    4 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    0 central nervous system, larvae L3    3 central nervous system, pupae P8  28 head, virgin 1-day female    12 head, virgin 4-day female    11 head, virgin 20-day female    4 head, mated 1-day female    10 head, mated 4-day female    8 head, mated 20-day female    4 head, mated 1-day male    14 head, mated 4-day male    14 head, mated 20-day male    9 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    4 carcass, larvae L3 wandering    1 carcass, 1-day adult    15 carcass, 4-day adult    11 carcass, 20-day adult    4 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    0 central nervous system, larvae L3    3 central nervous system, pupae P8    28 head, virgin 1-day female    12 head, virgin 4-day female    11 head, virgin 20-day female    4 head, mated 1-day female    10 head, mated 4-day female    8 head, mated 20-day female    4 head, mated 1-day male    14 head, mated 4-day male    14 head, mated 20-day male    9 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    4 carcass, larvae L3 wandering    1 carcass, 1-day adult    15 carcass, 4-day adult    11 carcass, 20-day adult    4 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    0 central nervous system, larvae L3    3 central nervous system, pupae P8    28 head, virgin 1-day female    12 head, virgin 4-day female    11 head, virgin 20-day female    4 head, mated 1-day female    10 head, mated 4-day female    8 head, mated 20-day female    4 head, mated 1-day male    14 head, mated 4-day male    14 head, mated 20-day male    9 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    4 carcass, larvae L3 wandering    1 carcass, 1-day adult    15 carcass, 4-day adult    11 carcass, 20-day adult    4 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    1 embryo 18-20hr    1 embryo 20-22hr    1 embryo 22-24hr    2 larva L1    1 larva L2    0 larva L3 12hr old    0 larva L3 puffstage 1-2    0 larva L3 puffstage 3-6    0 larva L3 puffstage 7-9    0 white prepupae new    0 white prepupae 12hr    1 white prepupae 24hr    1 pupae 2d postWPP    2 pupae 3d postWPP    9 pupae 4d postWPP    15 adult male 01day    8 adult male 05day    6 adult male 30day    4 adult female 01day    5 adult female 05day    1 adult female 30day    1 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    1 embryo 18-20hr    1 embryo 20-22hr    1 embryo 22-24hr    2 larva L1    1 larva L2    0 larva L3 12hr old    0 larva L3 puffstage 1-2    0 larva L3 puffstage 3-6    0 larva L3 puffstage 7-9    0 white prepupae new    0 white prepupae 12hr    1 white prepupae 24hr    1 pupae 2d postWPP    2 pupae 3d postWPP    9 pupae 4d postWPP    15 adult male 01day    8 adult male 05day    6 adult male 30day    4 adult female 01day    5 adult female 05day    1 adult female 30day    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    1 embryo 18-20hr    1 embryo 20-22hr    1 embryo 22-24hr    2 larva L1    1 larva L2    0 larva L3 12hr old    0 larva L3 puffstage 1-2    0 larva L3 puffstage 3-6    0 larva L3 puffstage 7-9    0 white prepupae new    0 white prepupae 12hr    1 white prepupae 24hr    1 pupae 2d postWPP    2 pupae 3d postWPP    9 pupae 4d postWPP    15 adult male 01day    8 adult male 05day    6 adult male 30day    4 adult female 01day    5 adult female 05day    1 adult female 30day    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    1 embryo 18-20hr    1 embryo 20-22hr    1 embryo 22-24hr    2 larva L1    1 larva L2    0 larva L3 12hr old    0 larva L3 puffstage 1-2    0 larva L3 puffstage 3-6    0 larva L3 puffstage 7-9    0 white prepupae new    0 white prepupae 12hr    1 white prepupae 24hr    1 pupae 2d postWPP    2 pupae 3d postWPP    9 pupae 4d postWPP    15 adult male 01day    8 adult male 05day    6 adult male 30day    4 adult female 01day    5 adult female 05day    1 adult female 30day    1 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    1 embryo 18-20hr    1 embryo 20-22hr    1 embryo 22-24hr    2 larva L1    1 larva L2    0 larva L3 12hr old    0 larva L3 puffstage 1-2    0 larva L3 puffstage 3-6    0 larva L3 puffstage 7-9    0 white prepupae new    0 white prepupae 12hr    1 white prepupae 24hr    1 pupae 2d postWPP    2 pupae 3d postWPP    9 pupae 4d postWPP    15 adult male 01day    8 adult male 05day    6 adult male 30day    4 adult female 01day    5 adult female 05day    1 adult female 30day    1 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    1 embryo 18-20hr    1 embryo 20-22hr    1 embryo 22-24hr    2 larva L1    1 larva L2    0 larva L3 12hr old    0 larva L3 puffstage 1-2    0 larva L3 puffstage 3-6    0 larva L3 puffstage 7-9    0 white prepupae new    0 white prepupae 12hr    1 white prepupae 24hr    1 pupae 2d postWPP    2 pupae 3d postWPP    9 pupae 4d postWPP    15 adult male 01day    8 adult male 05day    6 adult male 30day    4 adult female 01day    5 adult female 05day    1 adult female 30day    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    1 embryo 18-20hr    1 embryo 20-22hr    1 embryo 22-24hr    2 larva L1    1 larva L2    0 larva L3 12hr old    0 larva L3 puffstage 1-2    0 larva L3 puffstage 3-6    0 larva L3 puffstage 7-9    0 white prepupae new    0 white prepupae 12hr    1 white prepupae 24hr    1 pupae 2d postWPP    2 pupae 3d postWPP    9 pupae 4d postWPP    15 adult male 01day    8 adult male 05day    6 adult male 30day    4 adult female 01day    5 adult female 05day    1 adult female 30day    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    1 embryo 18-20hr    1 embryo 20-22hr    1 embryo 22-24hr    2 larva L1    1 larva L2    0 larva L3 12hr old    0 larva L3 puffstage 1-2    0 larva L3 puffstage 3-6    0 larva L3 puffstage 7-9    0 white prepupae new    0 white prepupae 12hr    1 white prepupae 24hr    1 pupae 2d postWPP    2 pupae 3d postWPP    9 pupae 4d postWPP    15 adult male 01day    8 adult male 05day    6 adult male 30day    4 adult female 01day    5 adult female 05day    1 adult female 30day    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    1 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    4 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    1 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    1 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    1 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    4 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    1 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    4 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    1 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    1 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    1 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    2 heat shock, 4-day adult    2 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    1 Cadmium 100 mM 48 hrs, 4-day adult    3 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    8 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    13 Ethanol 2.5% 3 hrs, larvae L3    2 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    2 Caffeine 25 mg/ml 48 hrs, 4-day adult    2 Paraquat 5 mM 48 hrs, 4-day adult    4 Paraquat 10 mM 48 hrs, 4-day adult    4 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    2 heat shock, 4-day adult    2 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    1 Cadmium 100 mM 48 hrs, 4-day adult    3 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    8 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    13 Ethanol 2.5% 3 hrs, larvae L3    2 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    2 Caffeine 25 mg/ml 48 hrs, 4-day adult    2 Paraquat 5 mM 48 hrs, 4-day adult    4 Paraquat 10 mM 48 hrs, 4-day adult    4 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    2 heat shock, 4-day adult    2 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    1 Cadmium 100 mM 48 hrs, 4-day adult    3 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    8 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    13 Ethanol 2.5% 3 hrs, larvae L3    2 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    2 Caffeine 25 mg/ml 48 hrs, 4-day adult    2 Paraquat 5 mM 48 hrs, 4-day adult    4 Paraquat 10 mM 48 hrs, 4-day adult    4 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    2 heat shock, 4-day adult    2 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    1 Cadmium 100 mM 48 hrs, 4-day adult    3 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    8 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    13 Ethanol 2.5% 3 hrs, larvae L3    2 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    2 Caffeine 25 mg/ml 48 hrs, 4-day adult    2 Paraquat 5 mM 48 hrs, 4-day adult    4 Paraquat 10 mM 48 hrs, 4-day adult    4 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    2 heat shock, 4-day adult    2 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    1 Cadmium 100 mM 48 hrs, 4-day adult    3 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    8 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    13 Ethanol 2.5% 3 hrs, larvae L3    2 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    2 Caffeine 25 mg/ml 48 hrs, 4-day adult    2 Paraquat 5 mM 48 hrs, 4-day adult    4 Paraquat 10 mM 48 hrs, 4-day adult    4 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    2 heat shock, 4-day adult    2 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    1 Cadmium 100 mM 48 hrs, 4-day adult    3 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    8 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    13 Ethanol 2.5% 3 hrs, larvae L3    2 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    2 Caffeine 25 mg/ml 48 hrs, 4-day adult    2 Paraquat 5 mM 48 hrs, 4-day adult    4 Paraquat 10 mM 48 hrs, 4-day adult    4 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    2 heat shock, 4-day adult    2 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    1 Cadmium 100 mM 48 hrs, 4-day adult    3 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    8 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    13 Ethanol 2.5% 3 hrs, larvae L3    2 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    2 Caffeine 25 mg/ml 48 hrs, 4-day adult    2 Paraquat 5 mM 48 hrs, 4-day adult    4 Paraquat 10 mM 48 hrs, 4-day adult    4 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    2 heat shock, 4-day adult    2 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    1 Cadmium 100 mM 48 hrs, 4-day adult    3 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    8 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    13 Ethanol 2.5% 3 hrs, larvae L3    2 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    2 Caffeine 25 mg/ml 48 hrs, 4-day adult    2 Paraquat 5 mM 48 hrs, 4-day adult    4 Paraquat 10 mM 48 hrs, 4-day adult    4 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_15 mE1_20_mRNA_expression_cluster_20
External Data & Images
Linkouts
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal pHClGD2478 lethal, with Scer\GAL4pnr-MD237 pHClGD2478 lethal | pupal stage, with Scer\GAL4pnr-MD237 pHClGD15583 viable, with Dcr-2Scer\UAS.cDa, Scer\GAL4e22c, Scer\GAL4sqh.PW pHClKK112646 viable, with Scer\GAL4pnr-MD237 pHClGD456 Other Phenotypes Allele neuroanatomy defective | larval stage pHClGD2478 Phenotype manifest in Allele embryonic/larval neuroblast | larval stage pHClGD2478 ganglion mother cell | larval stage pHClGD2478
Classical Alleles ( 6 )
For All Classical Alleles Show
Allele of pHCl Class Mutagen Stocks Known lesion pHClMB01759 1 -- pHClMB03119 1 -- pHClMB04971 1 -- pHClMB06931 1 -- pHClMI00180 1 -- pHClMI02269 1 --
Alleles Carried on Transgenic Constructs ( 8 )
For All Alleles Carried on Transgenic Constructs Show
Allele of pHCl Class Mutagen Stocks Known lesion pHClGD15583 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes pHClGD2478 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes pHClGD456 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes pHClGL00681 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes pHClHMS02265 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes pHClKK112287 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes pHClKK112646 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes pHClGD5140 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD456} NA P{GD2478} NA P{GD15583} NA P{KK112287} NA P{KK112646} NA P{TRiP.GL00681} NA P{TRiP.HMS02265} NA
Insertions
	Type of insertions Name Expression data insertion of enhancer trap binary system Mi{ET1}pHClMB01759 No Mi{ET1}pHClMB03119 No Mi{ET1}pHClMB04971 No Mi{ET1}pHClMB06931 No miscellaneous insertions Mi{MIC}pHClMI00180 NA Mi{MIC}pHClMI02269 NA
Gene Ontology: Function, Process & Cellular Component ( 5 unique terms )
Terms Based on Experimental Evidence ( 2 terms )
Molecular Function
CV term Evidence References
chloride channel activity inferred from direct assay (Schnizler et al., 2005)
Biological Process
CV term Evidence References
neurogenesis inferred from mutant phenotype (Neumüller et al., 2011)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 3 terms )
Molecular Function
CV term Evidence References
extracellular-glycine-gated chloride channel activity inferred from sequence or structural similarity with EMBL:U77731 (FlyBase, 1992-)
Biological Process
CV term Evidence References
ion transport inferred from electronic annotation with InterPro:IPR006028, InterPro:IPR006029, InterPro:IPR006201 (FlyBase Curators et al., 2004-)
Cellular Component
CV term Evidence References
glycine-gated chloride channel complex inferred from sequence or structural similarity with EMBL:U77731 (FlyBase, 1992-)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions pHCl allele Gene References
External Data
Linkouts
Orthologs
OrthoDB Orthologs (35) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG69W30Z, EOG62FT4R Dipteran inclusive ortholog search EOG63V03Q Insect inclusive ortholog search EOG6FQZMT Arthropod inclusive ortholog search EOG6J0ZQ8 Metazoa inclusive ortholog search No orthologs identified
Orthologs in Drosophila Species (EOG69W30Z, EOG62FT4R)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\pHCl     Drosophila simulans   Dsim\GD12531 Y   Drosophila sechellia   Dsec\GM24460 Y   Drosophila erecta   Dere\GG13514 Y   Drosophila yakuba   Dyak\GE19806     Drosophila ananassae   Dana\GF10370 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA23558 Y   Drosophila persimilis   Dper\GL24925 Y   Drosophila willistoni   Dwil\GK20603 Y   Drosophila virilis   Dvir\GJ11222 Y   Drosophila virilis   Dvir\GJ11221 Y   Drosophila mojavensis   Dmoj\GI11303 Y   Drosophila grimshawi   Dgri\GH14361 Y
Orthologs in non-Drosophila Dipterans (EOG63V03Q)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL001272   Aedes aegypti Yellow fever mosquito  Aaeg\AAEL015452   Anopheles gambiae Malaria mosquito  Agam\AGAP005599   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ002292   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ002295
Orthologs in non-Dipteran Insects (EOG6FQZMT)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB50207   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG010284   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH24274   Atta cephalotes Leafcutter ant  Acep\ACEP13927   Atta cephalotes Leafcutter ant  Acep\ACEP13929   Camponotus floridanus Florida carpenter ant  Cflo\CFLO16884   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL16885   Linepithema humile Argentine ant  Lhum\LH19012   Pogonomyrmex barbatus Red harvester ant  Pbar\PB12252   Pogonomyrmex barbatus Red harvester ant  Pbar\PB15331   Solenopsis invicta Red fire ant  Sinv\SINV22134   Acyrthosiphon pisum Pea aphid  Apim\ACYPI003723   Acyrthosiphon pisum Pea aphid  Apim\ACYPI003761   Bombyx mori Silkmoth  Bmor\BGIBMGA012504   Pediculus humanus Human body louse  Phum\PHUM267500   Tribolium castaneum Red flour beetle  Tcas\TC000240
Orthologs in non-Insect Arthropods (EOG6J0ZQ8)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Ixodes scapularis Deer tick  Isca\ISCW021195
Orthologs in non-Arthropod Metazoa (None identified)
No non-Arthropod Metazoa orthologies identified
Human Orthologs (0)
Gene OMIM HGNC
AAA Orthologs (14) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD12531 Drosophila sechellia Dsec\GM24460 Drosophila erecta Dere\GG13514 Drosophila erecta Dere\GG13515 Drosophila ananassae Dana\GF10370 Drosophila pseudoobscura pseudoobscura Dpse\GA23558 Drosophila persimilis Dper\GL24925 Drosophila willistoni Dwil\GK20603 Drosophila willistoni Dwil\GK20611 Drosophila virilis Dvir\GJ11221 Drosophila virilis Dvir\GJ11222 Drosophila mojavensis Dmoj\GI11303 Drosophila grimshawi Dgri\GH14361 Drosophila grimshawi Dgri\GH14362
Stocks & Reagents
Stocks Listed in FlyBase ( 14 )
Bloomington	24735 w1118; Mi{ET1}pHClMB04971 33185 y1 w*; Mi{MIC}pHClMI02269 23356 y1 w67c23; Mi{ET1}pHClMB01759 38909 y1 sc* v1; P{TRiP.GL00681}attP2 41700 y1 sc* v1; P{TRiP.HMS02265}attP40 25339 w1118; Mi{ET1}pHClMB06931/TM6C, Sb1
VDRC	v102729 P{KK112287}VIE-260B v103247 P{KK112646}VIE-260B v9513 w1118; P{GD456}v9513 v11020 w1118; P{GD2478}v11020 v39283 w1118; P{GD15583}v39283 v39282 w1118; P{GD15583}v39282/TM3
	More stocks available...
Genomic Clones ( 1 )
	BACR06P13 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 48 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GH21757 IP07260 RE33441
Other clones	MIP20290 MIP20390
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH14729 HL03865
Other clones	12302 41856 71625 75151 81552 99374 101266 119280 214439.28 274515 AM02141 CK01.41B.C11 CK01.75C.E7 CK01.92C.H6 CK01.110A.F2 CK01.116B.E1 CK02524 EK059120 EK072348 EK099353 EK112736 EK155018 EK159403 EK164437 EK199730 EK207161 EK213001 EK222061 EK243549 EK247609 EK302124 EP01744 EP02326 EP09647 IP07360 IP07460 IP07560 RP004178920 RP004231386 RP004440048 RP004488151
RNAi & Array Information
Linkouts
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: pHCl CG6112 (Gisselmann and Hatt, 2005.1.7)
Source for database merge of	Source for merge of: CG13444 BcDNA:GH21757 (FlyBase Genome Annotators, 2005, FlyBase, 1996-) Source for merge of: pHCl CG12486 (FlyBase Genome Annotators, 2012)
Additional comments	Annotations CG33989 and CG12486 merged as CG44099 in release 5.47 of the genome annotation. Merge supported by RNA-seq junction data. (FlyBase Genome Annotators, 2012) Source for merge of CG13444 BcDNA:GH21757 was a shared cDNA (date:030728). (FlyBase Genome Annotators, 2005, FlyBase, 1996-)
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_001038934 NM_001038935 NM_001038936 NM_001038937 NM_001169979 NM_001259852 NM_001259853 NM_001274965 NM_001274966 NM_001274967 NM_001274968 NM_001274969 NM_001274970 NM_001274971 RefSeq (Proteins) • NP_001034023 NP_001034024 NP_001034025 NP_001034026 NP_001163450 NP_001246781 NP_001246782 NP_001261894 NP_001261895 NP_001261896 NP_001261897 NP_001261898 NP_001261899 NP_001261900 DDBJ / EMBL / GenBank • AAF49570 AAF49570.1 AAF49571 AAF49571.1 AAF49572 AAL25367 AAX11175 AAX11176 AAX11177 ABC66135 ABC66136 ACZ94721 AFH04452 AFH04453 AGB94587 AGB94588 AGB94589 AGB94590 AGB94591 AGB94592 AGB94593 AI402520 AW941844 AY060328 AY880248 AY880249 AY880250 CX309455 CX309456 Entrez Gene - A searchable database of RefSeq genes. • 39729 39730 UniProtKB/TrEMBL • E1JI08 Q2PDY9 Q2PDZ0 Q5D6V9 Q5D6W0 Q5D6W1 Q9VUV1 Q9VUV2 Q9VUV3 Q95T52
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Glutamate-Gated Chloride Channel (IPR015680) Gamma-aminobutyric acid A receptor (IPR006028) Neurotransmitter-gated ion-channel (IPR006201) Neurotransmitter-gated ion-channel ligand-binding (IPR006202) Neurotransmitter-gated ion-channel transmembrane domain (IPR006029)
Linkouts
Synonyms & Secondary IDs ( 12 )
Reported As
Symbol Synonym	BcDNA:GH21757   BP1024 (Yandell et al., 2005, ) CG6112 (Schnizler et al., 2005) CG12486 (Izutsu et al., 2012) CG13444   CG33989 (Tsubouchi et al., 2012, FlyBase Genome Annotators, 2005, Keleman et al., 2009.8.5) CG44099 (FlyBase Genome Annotators, 2012, Ni et al., 2010.12.1) CT19189 (Witte et al., 2002) pHCl (Tsubouchi et al., 2012, Izutsu et al., 2012, Dalton et al., 2010) pHCL-A (Junion et al., 2007) unnamed (Yandell et al., 2005)
Name Synonym	glutamate-gated chloride channel-like (Witte et al., 2002) pHCl (FlyBase Genome Annotators, 2012)
Secondary FlyBase IDs
	FBgn0036541 FBgn0036542 FBgn0036543 FBgn0046788 FBgn0053989 FBgn0082882 FBpp0075286 FBpp0075287 FBtr0075531 FBtr0075532
References ( 34 )
Generate a list of	All references relating to this gene ( 34 )
List References by type	Research paper  ( 7 ) Supplementary material  ( 8 ) Personal communication to FlyBase  ( 11 ) FlyBase analysis  ( 5 ) DNA/RNA sequence record  ( 1 ) Curated genome annotation  ( 2 )
Recent research papers ( 2 )
	Izutsu et al., 2012, PLoS ONE 7(3): e33288 Genome features of "dark-fly", a Drosophila line reared long-term in a dark environment. [FBrf0217825] Weber et al., 2012, PLoS ONE 7(4): e34745 Genome-Wide Association Analysis of Oxidative Stress Resistance in Drosophila melanogaster. [FBrf0218073] Show all research papers ...