FB2020_02, released Apr 14, 2020

Gene: Dmel\Src42A

Open Close
General Information
Symbol
Dmel\Src42A
Species
D. melanogaster
Name
Src oncogene at 42A
Annotation Symbol
CG44128
Feature Type
protein_coding_gene
FlyBase ID
FBgn0264959
Gene Model Status
Current
Stock Availability
31 publicly available
Enzyme Name (EC)
Non-specific protein-tyrosine kinase (2.7.10.2)
Gene Snapshot
Src oncogene at 42A (Src42A) encodes the none-receptor tyrosine kinase regulating cell proliferation, cell adhesion and morphogenetic processes including dorsal closure, tracheal tube size control and germ band elongation. It is regulated by both inhibitory and activating tyrosine phosphorylation. [Date last reviewed: 2019-09-26]
Other Summaries
Also Known As

Src, Dsrc41, Src42, Dsrc42A, DmHD-29

Key Links
Genomic Location
Cytogenetic map
42A6-42A7
Sequence location
2R:5,981,844..6,012,795 [+]
Recombination map

2-55

RefSeq locus
NT_033778 REGION:5981844..6012795
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Group (FlyBase)
Pathway (FlyBase)
Protein Family (UniProt)
Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily. (Q9V9J3)
Protein Signatures (InterPro)
Molecular Function (GO)
[Detailed GO annotations]
Experimental Evidence
non-membrane spanning protein tyrosine kinase activity
Predictions / Assertions
ATP binding; non-membrane spanning protein tyrosine kinase activity; protein tyrosine kinase activity; signaling receptor binding
Catalytic Activity (EC)
Experimental Evidence
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate (2.7.10.2)
Predictions / Assertions
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate (2.7.10.2)
Summaries
Gene Group (FlyBase)
NON-RECEPTOR TYROSINE KINASES -
Non-Receptor Tyrosine kinases (nRTK) are cytoplasmic protein kinases that specifically phosphorylate tyrosine residues. nRTKs are involved in signalling cascades and possess targeting domains such as SH2 domains. (Adapted from FBrf0132098).
Pathway (FlyBase)
Negative Regulators of EGFR Signaling Pathway -
Negative regulators of Epidermal Growth Factor Receptor signaling down-regulate the pathway, suppressing the activation of ERK kinase (rl) or acting on downstream effectors.
Positive Regulators of EGFR Signaling Pathway -
Positive regulators of Epidermal Growth Factor Receptor signaling up-regulate the pathway, enhancing the activation of ERK kinase (rl) or acting on downstream effectors.
Positive Regulators of Sevenless Signaling Pathway -
Positive regulators of Sevenless signaling up-regulate the pathway, promoting cell fate to that of an R7 photoreceptor. (Adapted from FBrf0127283 and FBrf0221727).
Protein Function (UniProtKB)
Required directly or indirectly for the phosphorylation of drpr which is necessary for the interaction of drpr with shark and subsequent glial phagocytic activity (PubMed:18432193). Together with drpr and shark, promotes the migration of macrophages to sites of wounding as part of a signaling cascade where Scr42a detects production of hydrogen peroxide at wound sites which triggers phosphorylation of drpr and subsequent recruitment and activation of shark (PubMed:26028435). Essential for correct eye morphogenesis (ommatidial R7 neuron formation) which requires the Ras1/MAPK signal transduction pathway (PubMed:8682295). May be involved in the regulation of cytoskeleton organization and cell-cell contacts in developing ommatidia (PubMed:8682295). During embryogenesis, involved in regulation of dorsal closure where it may have a role in activating the JNK pathway in leading edge cells during this process (PubMed:16831834).
(UniProt, Q9V9J3)
Summary (Interactive Fly)

Src homolog - a protein tyrosine kinase with SH3 and SH2 domains - essential for cell-cell matching during dorsal closure - involved in adherins junction stabilization

Gene Model and Products
Number of Transcripts
2
Number of Unique Polypeptides
2

Please see the GBrowse view of Dmel\Src42A or the JBrowse view of Dmel\Src42A for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.47

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Src42A-RA
FBtr0335275
NM_057501
3017
517
Src42A-RB
FBtr0335276
NM_136347
6398
1597
Additional Transcript Data and Comments
Reported size (kB)

3.0 (northern blot)

(Takahashi et al., 1996)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
Src42A-PA
FBpp0307254
59.1
517
6.65
NP_476849
AAF57295
Src42A-PB
FBpp0307255
176.0
1597
8.70
NP_610191
AAM68338
Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments
Reported size (kDa)

517 (aa)

(Takahashi et al., 1996)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Src42A using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Gene Ontology (34 terms)
Molecular Function (4 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
non-membrane spanning protein tyrosine kinase activity
inferred from direct assay
(Santhanam et al., 2014, Laberge et al., 2005, Muda et al., 2002)
Terms Based on Predictions or Assertions (4 terms)
CV Term
Evidence
References
ATP binding
inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR017441
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
non-membrane spanning protein tyrosine kinase activity
inferred from biological aspect of ancestor with PANTHER:PTN002521528
(assigned by GO_Central )
(Gaudet et al., 2011)
protein tyrosine kinase activity
non-traceable author statement
(assigned by UniProt )
(Takahashi et al., 1996)
signaling receptor binding
inferred from biological aspect of ancestor with PANTHER:PTN002521528
(assigned by GO_Central )
(Gaudet et al., 2011)
Biological Process (27 terms)
Terms Based on Experimental Evidence (23 terms)
CV Term
Evidence
References
actin filament bundle assembly
inferred from mutant phenotype
(Murray et al., 2006)
adherens junction organization
inferred from mutant phenotype
(Shindo et al., 2008)
apoptotic cell clearance
inferred from mutant phenotype
(Ziegenfuss et al., 2008)
axon guidance
inferred from mutant phenotype
(O'Donnell and Bashaw, 2013)
cell migration
inferred from mutant phenotype
(Ma et al., 2013)
compound eye development
inferred from mutant phenotype
(Takahashi et al., 1996)
defense response to bacterium
inferred from mutant phenotype
(Cordero et al., 2014)
dorsal closure
inferred from mutant phenotype
(Murray et al., 2006, Tateno et al., 2000)
inferred from genetic interaction with FLYBASE:FER; FB:FBgn0000723
(Murray et al., 2006)
inferred from genetic interaction with FLYBASE:bsk; FB:FBgn0000229
(Tateno et al., 2000)
inferred from genetic interaction with FLYBASE:hep; FB:FBgn0010303
(Tateno et al., 2000)
inferred from genetic interaction with FLYBASE:Src64B; FB:FBgn0262733
(Tateno et al., 2000)
dorsal closure, spreading of leading edge cells
inferred from mutant phenotype
(Takahashi et al., 2005)
epithelial cell-cell adhesion
inferred from mutant phenotype
(Shindo et al., 2008)
imaginal disc fusion, thorax closure
inferred from mutant phenotype
(Takahashi et al., 2005)
imaginal disc-derived wing morphogenesis
inferred from mutant phenotype
(Dworkin and Gibson, 2006)
intestinal stem cell homeostasis
inferred from mutant phenotype
(Cordero et al., 2014)
negative regulation of epidermal growth factor receptor signaling pathway
inferred from genetic interaction with FLYBASE:Sos; FB:FBgn0001965, FLYBASE:Ras85D; FB:FBgn0003205
(Lu and Li, 1999)
negative regulation of synaptic growth at neuromuscular junction
inferred from genetic interaction with FLYBASE:Fak; FB:FBgn0020440
(Tsai et al., 2008)
open tracheal system development
inferred from mutant phenotype
(Shindo et al., 2008, Matusek et al., 2006)
peptidyl-tyrosine phosphorylation
inferred from mutant phenotype
(Muda et al., 2002)
positive regulation of epidermal growth factor receptor signaling pathway
inferred from mutant phenotype
(Laberge et al., 2005)
positive regulation of ERK1 and ERK2 cascade
inferred from direct assay
(Laberge et al., 2005)
positive regulation of sevenless signaling pathway
inferred from direct assay
(Laberge et al., 2005)
protein phosphorylation
inferred from direct assay
(Muda et al., 2002)
inferred from mutant phenotype
(Muda et al., 2002)
regulation of synaptic plasticity
inferred from genetic interaction with FLYBASE:GluRIIA; FB:FBgn0004620
(Spring et al., 2016)
salivary gland morphogenesis
inferred from mutant phenotype
(Harris and Beckendorf, 2007)
Terms Based on Predictions or Assertions (4 terms)
CV Term
Evidence
References
cell differentiation
inferred from biological aspect of ancestor with PANTHER:PTN002521528
(assigned by GO_Central )
(Gaudet et al., 2011)
peptidyl-tyrosine autophosphorylation
inferred from biological aspect of ancestor with PANTHER:PTN002521528
(assigned by GO_Central )
(Gaudet et al., 2011)
regulation of cell population proliferation
inferred from biological aspect of ancestor with PANTHER:PTN002521528
(assigned by GO_Central )
(Gaudet et al., 2011)
transmembrane receptor protein tyrosine kinase signaling pathway
inferred from biological aspect of ancestor with PANTHER:PTN002521528
(assigned by GO_Central )
(Gaudet et al., 2011)
Cellular Component (3 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
cytoplasm
inferred from high throughput direct assay
(Lee et al., 2014)
plasma membrane
inferred from high throughput direct assay
(Lee et al., 2014, Tan et al., 2009)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
extrinsic component of cytoplasmic side of plasma membrane
inferred from biological aspect of ancestor with PANTHER:PTN002521528
(assigned by GO_Central )
(Gaudet et al., 2011)
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 13 -- 16
ventral nerve cord
(Takahashi et al., 1996)
supraesophageal ganglion
(Takahashi et al., 1996)
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 1 -- 3
organism

Comment: maternally deposited

(Fisher et al., 2012)
embryonic stage 4 -- 6
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 7 -- 8
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 9 -- 10
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 11 -- 12
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 1 -- 5
organism | ubiquitous
(Takahashi et al., 1996)
third instar larval stage
embryonic/larval garland cell
(Tutor et al., 2014)
embryonic stage 14
ventral nerve cord
(Wouda et al., 2008)
embryonic/larval gut
(Wouda et al., 2008)
embryonic stage
commissure
(Wouda et al., 2008)
longitudinal connective
(Wouda et al., 2008)
northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage & pupal stage
(Takahashi et al., 1996)
third instar larval stage
eye-antennal disc
(Takahashi et al., 1996)
wing disc
(Takahashi et al., 1996)
central nervous system
(Takahashi et al., 1996)
ventral thoracic disc
(Takahashi et al., 1996)
embryonic stage 13 -- 16
anal pad
(Takahashi et al., 1996)
visceral mesoderm
(Takahashi et al., 1996)
embryonic/larval hindgut
(Takahashi et al., 1996)
Additional Descriptive Data

Src42A transcripts are observe throughout the embryonic ventral nerve cord and gut. The Src42A transcript distribution overlaps with drl in the ventral nerve cord in the anterior part of each segment. Both are expressed in axonal projections.

(Wouda et al., 2008)

Src42A transcripts are first detected in stage 2-3 embryos. They are uniformly expressed in the embryo until the end of germ band retraction. At stages 13-16, high expression is observed in visceral mesoderm, hindgut, brain, anal pads, and ventral ganglion. In third instar larvae, expression is strong in the CNS. In addition, almost all cells in the eye-antennal, wing and leg discs express Src42A.

(Takahashi et al., 1996)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 11
tracheal primordium

Comment: pSrc distribution

(Shindo et al., 2008)
embryonic stage
embryonic/larval dorsal branch

Comment: pSrc distribution

(Shindo et al., 2008)
metameric furrow

Comment: pSrc distribution

(Shindo et al., 2008)
embryonic/larval hindgut

Comment: pSrc distribution

(Shindo et al., 2008)
embryonic/larval posterior spiracle

Comment: pSrc distribution

(Shindo et al., 2008)
embryonic/larval salivary gland

Comment: pSrc distribution

(Shindo et al., 2008)
parasegmental furrow

Comment: pSrc distribution

(Shindo et al., 2008)
embryonic stage 16
organism | ubiquitous
(Förster and Luschnig, 2012)
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
Additional Descriptive Data

Activated Src42A protein appears to be localized in close proximity to shg-positive adherens junctions and/or other types of shg aggregates.

(Takahashi et al., 1996)
Marker for
 
Subcellular Localization
CV Term
Evidence
References
cytoplasm
inferred from high throughput direct assay
(Lee et al., 2014)
plasma membrane
inferred from high throughput direct assay
(Lee et al., 2014, Tan et al., 2009)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Src42A in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 43 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 21 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Src42A
Transgenic constructs containing regulatory region of Src42A
Deletions and Duplications ( 8 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal
lethal, with Scer\GAL4GMR.PF
lethal, with Scer\GAL4hs.2sev
lethal (with Df(2R)BSC889)
lethal | recessive
lethal - all die before end of embryonic stage | partially
lethal - all die before end of embryonic stage | recessive
lethal - all die before end of first instar larval stage
lethal - all die before end of larval stage | recessive
viable
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4pnr-MD237
viable, with Scer\GAL4tin.CΔ4
Sterility
Allele
female semi-sterile, with Scer\GAL4VP16.mat.αTub67C
fertile
Other Phenotypes
Allele
cell adhesion defective | wandering third instar larval stage, with Scer\GAL4GMR.PF
cell number defective | conditional, with Scer\GAL4NP5130
decreased occurrence of cell division | adult stage | conditional
decreased occurrence of cell division | adult stage | conditional, with Scer\GAL4NP5130
hyperplasia, with Scer\GAL4NP5130
increased cell death, with Scer\GAL4GMR.PF
increased occurrence of cell division | adult stage, with Scer\GAL4NP5130
increased occurrence of cell division | adult stage, with Scer\GAL4NP7397
increased occurrence of cell division | larval stage, with Scer\GAL4GMR.PF
majority die during larval stage, with Scer\GAL4hs.2sev
neuroanatomy defective
neuroanatomy defective | wandering third instar larval stage, with Scer\GAL4GMR.PF
pain response defective | adult stage, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
size defective | adult stage, with Scer\GAL4GMR.PF
size defective | wandering third instar larval stage, with Scer\GAL4GMR.PF
some die during embryonic stage | partially
some die during embryonic stage | recessive
some die during first instar larval stage
some die during larval stage | recessive
stress response defective | adult stage
stress response defective | adult stage, with Scer\GAL4NP5130
visible, with Scer\GAL4Mef2.PR
visible, with Scer\GAL4pnr-MD237
visible | dominant
visible | recessive
wild-type
Phenotype manifest in
Allele
actin filament | ectopic, with Scer\GAL4slbo.2.6
adherens junction | wandering third instar larval stage, with Scer\GAL4GMR.PF
adult midgut, with Scer\GAL4NP5130
adult midgut | conditional
adult thorax
adult thorax | dorsal
border follicle cell, with Scer\GAL4slbo.2.6
cephalopharyngeal skeleton
commissure
dorsal hair
egg
embryo | dorsal closure stage
embryonic/first instar larval cuticle
embryonic/larval dorsal branch | embryonic stage
embryonic/larval dorsal branch | embryonic stage, with Scer\GAL4btl.PS, Src42A26-1
embryonic/larval dorsal branch | embryonic stage, with Scer\GAL4btl.PS, Src42ANIG.7873R
embryonic/larval dorsal trunk
embryonic/larval dorsal trunk, with Scer\GAL4btl.PS
embryonic/larval dorsal trunk, with Scer\GAL4btl.PS, Src42A26-1
embryonic/larval dorsal trunk, with Scer\GAL4btl.PS, Src42ANIG.7873R
embryonic/larval dorsal trunk | embryonic stage
embryonic/larval dorsal trunk | embryonic stage, with Scer\GAL4btl.PS
embryonic/larval ganglionic branch | embryonic stage
embryonic/larval mouth
embryonic/larval trachea
embryonic/larval trachea, with Scer\GAL4btl.PS
embryonic/larval tracheal system
embryonic/larval transverse connective | embryonic stage
embryonic dorsal epidermis
embryonic leading edge cell, with Scer\GAL4pnr-MD237
embryonic leading edge cell & actomyosin
embryonic segment
eye, with Scer\GAL4GMR.PF
eye disc | larval stage, with Scer\GAL4GMR.PF
eye disc | wandering third instar larval stage, with Scer\GAL4GMR.PF
interommatidial bristle | ectopic, with Scer\GAL4GMR.PF
intestinal stem cell of posterior adult midgut epithelium, with Scer\GAL4NP5130
intestinal stem cell of posterior adult midgut epithelium, with Scer\GAL4NP7397
intestinal stem cell of posterior adult midgut epithelium | conditional
intestinal stem cell of posterior adult midgut epithelium | conditional, with Scer\GAL4NP5130
ipsilateral tract
larval head
mesothoracic bristle
midline primordium
ommatidium
photoreceptor cell
photoreceptor R3 precursor cell | wandering third instar larval stage, with Scer\GAL4GMR.PF
photoreceptor R4 precursor cell | wandering third instar larval stage, with Scer\GAL4GMR.PF
presumptive embryonic/larval central nervous system
presumptive embryonic salivary gland
rhabdomere
rhabdomere R7, with Scer\GAL4Rh3.PP
scutum
taenidial fold
trichogen cell | supernumerary, with Scer\GAL4pnr-MD237
wing
wing, with Scer\GAL4Mef2.PR
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v7.1)
Homo sapiens (Human) (27)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\FRK
14 of 15
Yes
Yes
Hsap\FYN
7 of 15
No
No
 
Hsap\YES1
6 of 15
No
No
Hsap\SRC
5 of 15
No
No
Hsap\BLK
4 of 15
No
No
Hsap\FGR
4 of 15
No
No
Hsap\HCK
4 of 15
No
No
Hsap\LCK
4 of 15
No
No
Hsap\LYN
4 of 15
No
No
Hsap\PTK6
3 of 15
No
Yes
Hsap\SRMS
3 of 15
No
Yes
Hsap\BMX
1 of 15
No
No
Hsap\BTK
1 of 15
No
No
 
Hsap\CSK
1 of 15
No
No
Hsap\GRAP2
1 of 15
No
No
Hsap\GRAP
1 of 15
No
No
 
Hsap\GRAPL
1 of 15
No
No
Hsap\GRB2
1 of 15
No
No
Hsap\ITK
1 of 15
No
No
Hsap\JAK1
1 of 15
No
No
Hsap\JAK2
1 of 15
No
No
Hsap\JAK3
1 of 15
No
No
Hsap\MATK
1 of 15
No
No
 
 
Hsap\TEC
1 of 15
No
No
Hsap\TXK
1 of 15
No
No
Hsap\TYK2
1 of 15
No
No
Hsap\ZBTB24
1 of 15
No
No
 
Model Organism Orthologs (via DIOPT v7.1)
Mus musculus (laboratory mouse) (26)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Frk
14 of 15
Yes
Yes
Mmus\Fyn
6 of 15
No
No
Mmus\Src
6 of 15
No
No
Mmus\Yes1
6 of 15
No
No
Mmus\Fgr
5 of 15
No
No
Mmus\Blk
4 of 15
No
No
Mmus\Hck
4 of 15
No
No
Mmus\Lck
4 of 15
No
No
Mmus\Lyn
4 of 15
No
No
Mmus\Ptk6
3 of 15
No
Yes
Mmus\Srms
3 of 15
No
Yes
Mmus\Gm11787
2 of 15
No
Yes
Mmus\Bmx
1 of 15
No
No
Mmus\Btk
1 of 15
No
No
Mmus\Csk
1 of 15
No
No
Mmus\Grap2
1 of 15
No
No
Mmus\Grap
1 of 15
No
No
Mmus\Grb2
1 of 15
No
No
Mmus\Itk
1 of 15
No
No
Mmus\Jak1
1 of 15
No
No
Mmus\Jak2
1 of 15
No
No
Mmus\Jak3
1 of 15
No
No
Mmus\Matk
1 of 15
No
No
Mmus\Tec
1 of 15
No
No
Mmus\Txk
1 of 15
No
No
Mmus\Tyk2
1 of 15
No
No
Rattus norvegicus (Norway rat) (23)
Rnor\Frk
12 of 13
Yes
Yes
Rnor\Fyn
6 of 13
No
No
Rnor\Src
6 of 13
No
No
Rnor\Fgr
5 of 13
No
No
Rnor\Yes1
5 of 13
No
No
Rnor\Blk
4 of 13
No
No
Rnor\Hck
4 of 13
No
No
Rnor\Lck
4 of 13
No
No
Rnor\Lyn
4 of 13
No
No
Rnor\Ptk6
3 of 13
No
Yes
Rnor\Srms
3 of 13
No
Yes
Rnor\Bmx
1 of 13
No
No
Rnor\Csk
1 of 13
No
No
Rnor\Grap2
1 of 13
No
No
Rnor\Grap
1 of 13
No
No
Rnor\Grb2
1 of 13
No
No
Rnor\Itk
1 of 13
No
No
Rnor\Jak1
1 of 13
No
No
Rnor\LOC103690155
1 of 13
No
No
Rnor\Matk
1 of 13
No
No
Rnor\Tec
1 of 13
No
No
Rnor\Txk
1 of 13
No
No
Rnor\Tyk2
1 of 13
No
No
Xenopus tropicalis (Western clawed frog) (23)
Xtro\yes1
5 of 12
Yes
No
Xtro\fyn
4 of 12
No
No
Xtro\fgr
3 of 12
No
No
Xtro\frk
3 of 12
No
Yes
Xtro\lck
3 of 12
No
Yes
Xtro\lyn
3 of 12
No
No
Xtro\src
3 of 12
No
No
Xtro\blk
2 of 12
No
Yes
Xtro\hck
2 of 12
No
Yes
Xtro\LOC100491469
2 of 12
No
Yes
Xtro\ptk6
2 of 12
No
Yes
Xtro\srms
2 of 12
No
Yes
Xtro\btk
1 of 12
No
No
Xtro\csk
1 of 12
No
No
Xtro\grap2
1 of 12
No
No
Xtro\grap
1 of 12
No
No
Xtro\grb2
1 of 12
No
No
Xtro\jak1
1 of 12
No
No
Xtro\jak2
1 of 12
No
No
Xtro\jak3
1 of 12
No
No
Xtro\LOC101733045
1 of 12
No
Yes
Xtro\tec
1 of 12
No
No
Xtro\tyk2
1 of 12
No
No
Danio rerio (Zebrafish) (31)
Drer\frk
11 of 15
Yes
Yes
Drer\yes1
7 of 15
No
No
Drer\fyna
6 of 15
No
No
Drer\fynb
6 of 15
No
No
Drer\src
5 of 15
No
No
Drer\hck
4 of 15
No
No
Drer\lck
4 of 15
No
No
Drer\yrk
4 of 15
No
No
Drer\blk
3 of 15
No
No
Drer\lyn
3 of 15
No
No
Drer\ptk6b
3 of 15
No
Yes
Drer\si:ch73-340m8.2
3 of 15
No
No
Drer\ptk6a
2 of 15
No
Yes
Drer\zgc:194282
2 of 15
No
Yes
Drer\btk
1 of 15
No
No
Drer\csk
1 of 15
No
No
Drer\grap2a
1 of 15
No
No
Drer\grap2b
1 of 15
No
No
Drer\grapa
1 of 15
No
No
Drer\grapb
1 of 15
No
No
Drer\grb2a
1 of 15
No
No
Drer\grb2b
1 of 15
No
No
Drer\itk
1 of 15
No
No
Drer\jak1
1 of 15
No
No
Drer\jak2a
1 of 15
No
No
Drer\jak2b
1 of 15
No
No
Drer\LOC101884146
1 of 15
No
Yes
Drer\matk
1 of 15
No
No
Drer\si:ch211-25d12.7
1 of 15
No
Yes
Drer\si:ch211-167j9.5
1 of 15
No
Yes
Drer\txk
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (8)
Cele\src-2
15 of 15
Yes
Yes
Cele\src-1
4 of 15
No
No
Cele\Y47G6A.5
2 of 15
No
Yes
Cele\abl-1
1 of 15
No
No
Cele\F39B2.5
1 of 15
No
No
Cele\kin-6
1 of 15
No
No
Cele\sem-5
1 of 15
No
No
Cele\T06C10.3
1 of 15
No
No
Arabidopsis thaliana (thale-cress) (12)
Atha\AT2G24360
1 of 9
Yes
No
Atha\AT3G50720
1 of 9
Yes
No
Atha\AT4G31170
1 of 9
Yes
No
Atha\AT5G01850
1 of 9
Yes
Yes
Atha\AT5G40540
1 of 9
Yes
Yes
Atha\AT5G47070
1 of 9
Yes
Yes
Atha\AT5G50180
1 of 9
Yes
Yes
Atha\AT5G58950
1 of 9
Yes
No
Atha\AT5G66710
1 of 9
Yes
No
Atha\ATN1
1 of 9
Yes
Yes
Atha\HT1
1 of 9
Yes
No
Atha\RKF1
1 of 9
Yes
Yes
Saccharomyces cerevisiae (Brewer's yeast) (3)
Scer\LSB1
1 of 15
Yes
No
Scer\NBP2
1 of 15
Yes
Yes
Scer\PIN3
1 of 15
Yes
No
Schizosaccharomyces pombe (Fission yeast) (2)
Spom\skb5
1 of 12
Yes
Yes
Spom\SPBC119.05c
1 of 12
Yes
Yes
Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG091905S1 )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00008156
Drosophila simulans
Dsim\GD10390
Drosophila sechellia
Dsec\GM16530
Drosophila erecta
Dere\GG23190
Drosophila yakuba
Dyak\GE20659
Drosophila ananassae
Dana\GF11039
Drosophila pseudoobscura pseudoobscura
Dpse\GA24271
Drosophila persimilis
Dper\GL16696
Drosophila willistoni
Dwil\GK27518
Drosophila willistoni
Dwil\GK21551
Drosophila virilis
Dvir\GJ17854
Drosophila virilis
Dvir\GJ26038
Drosophila virilis
Dvir\GJ26028
Drosophila mojavensis
Dmoj\GI19952
Drosophila mojavensis
Dmoj\GI26152
Drosophila grimshawi
Dgri\GH21475
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG0915052W )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17005489
Musca domestica
House fly
Mdoa\17020872
Glossina morsitans
Tsetse fly
Gmor\GMOY003984
Glossina morsitans
Tsetse fly
Gmor\GMOY007115
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_13597
Mayetiola destructor
Hessian fly
Mdes\Mdes019033
Mayetiola destructor
Hessian fly
Mdes\Mdes010264
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL004592
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL002471
Anopheles darlingi
American malaria mosquito
Adar\ADAC003474
Anopheles darlingi
American malaria mosquito
Adar\ADAC007380
Anopheles gambiae
Malaria mosquito
Agam\AGAP006270
Anopheles gambiae
Malaria mosquito
Agam\AGAP006510
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ007458
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ010659
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W00MF )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA000973
Bombyx mori
Silkmoth
Bmor\BGIBMGA004089
Bombyx mori
Silkmoth
Bmor\BGIBMGA002069
Bombyx mori
Silkmoth
Bmor\BGIBMGA012094
Bombyx mori
Silkmoth
Bmor\BGIBMGA000974
Bombyx mori
Silkmoth
Bmor\BGIBMGA000972
Danaus plexippus
Monarch butterfly
Dple\DPOGS207312-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS207465-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS200085-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS211780-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS211781-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL016683
Heliconius melpomene
Postman butterfly
Hmel\HMEL015762
Heliconius melpomene
Postman butterfly
Hmel\HMEL015066
Heliconius melpomene
Postman butterfly
Hmel\HMEL017653
Apis florea
Little honeybee
Aflo\2188804676
Apis florea
Little honeybee
Aflo\2802943476
Apis florea
Little honeybee
Aflo\2623606004
Apis florea
Little honeybee
Aflo\2152282052
Apis mellifera
Western honey bee
Amel\LOC412588
Apis mellifera
Western honey bee
Amel\GB47566
Apis mellifera
Western honey bee
Amel\LOC409127
Apis mellifera
Western honey bee
Amel\GB46371
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP17868
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP21745
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP16169
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP12987
Bombus terrestris
Buff-tailed bumblebee
Bter\15208566
Bombus terrestris
Buff-tailed bumblebee
Bter\15209628
Bombus terrestris
Buff-tailed bumblebee
Bter\15213667
Bombus terrestris
Buff-tailed bumblebee
Bter\15205435
Linepithema humile
Argentine ant
Lhum\LH10586
Linepithema humile
Argentine ant
Lhum\LH11572
Linepithema humile
Argentine ant
Lhum\LH24553
Linepithema humile
Argentine ant
Lhum\LH22348
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:0015bc
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:0002f3
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:001ea3
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG009131
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG016443
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG006407
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG009605
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_00955
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_12391
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_08800
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_09867
Tribolium castaneum
Red flour beetle
Tcas\TC034634
Tribolium castaneum
Red flour beetle
Tcas\TC002522
Tribolium castaneum
Red flour beetle
Tcas\TC031200
Tribolium castaneum
Red flour beetle
Tcas\GLEAN_07809
Pediculus humanus
Human body louse
Phum\PHUM538010
Pediculus humanus
Human body louse
Phum\PHUM305940
Pediculus humanus
Human body louse
Phum\PHUM378190
Pediculus humanus
Human body louse
Phum\PHUM118390
Rhodnius prolixus
Kissing bug
Rpro\RPRC012995
Rhodnius prolixus
Kissing bug
Rpro\Src64B
Rhodnius prolixus
Kissing bug
Rpro\RPRC008334
Rhodnius prolixus
Kissing bug
Rpro\Src42
Cimex lectularius
Bed bug
Clec\CLEC005989
Cimex lectularius
Bed bug
Clec\CLEC010008
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI007038
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI001933
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI009437
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI001730
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_09483
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_03797
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_07944
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_05378
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X04UG )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR006943
Strigamia maritima
European centipede
Smar\SMAR004801
Ixodes scapularis
Black-legged tick
Isca\ISCW006822
Ixodes scapularis
Black-legged tick
Isca\ISCW007829
Stegodyphus mimosarum
African social velvet spider
Smim\KFM65346.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM66538.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur12g02400
Tetranychus urticae
Two-spotted spider mite
Turt\tetur07g01370
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_305164
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0D46 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Sfk3
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Sfk5
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Btk
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Frk
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Abl
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Sfk1h
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Skf6
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Frk_1
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Sfk7
Ciona intestinalis
Vase tunicate
Cint\LOC445711
Ciona intestinalis
Vase tunicate
Cint\LOC100183015
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000016554
Ciona intestinalis
Vase tunicate
Cint\LOC100184615
Ciona intestinalis
Vase tunicate
Cint\LOC100180374
Ciona intestinalis
Vase tunicate
Cint\LOC100184799
Ciona intestinalis
Vase tunicate
Cint\LOC100177921
Gallus gallus
Domestic chicken
Ggal\SRC
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000004785
Gallus gallus
Domestic chicken
Ggal\SRMS
Gallus gallus
Domestic chicken
Ggal\LYN
Gallus gallus
Domestic chicken
Ggal\FRK
Gallus gallus
Domestic chicken
Ggal\BLK
Gallus gallus
Domestic chicken
Ggal\ITK
Gallus gallus
Domestic chicken
Ggal\BMX
Gallus gallus
Domestic chicken
Ggal\BTK
Gallus gallus
Domestic chicken
Ggal\FYN
Gallus gallus
Domestic chicken
Ggal\TEC
Gallus gallus
Domestic chicken
Ggal\YES1
Gallus gallus
Domestic chicken
Ggal\TXK
Gallus gallus
Domestic chicken
Ggal\ABL1
Gallus gallus
Domestic chicken
Ggal\LCK
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000004213
Gallus gallus
Domestic chicken
Ggal\HCK
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v7.1)
Drosophila melanogaster (Fruit fly) (14)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
Src64B
8 of 10
Btk29A
4 of 10
Csk
4 of 10
Shark
4 of 10
Ack-like
3 of 10
Abl
2 of 10
Ack
2 of 10
FER
2 of 10
CG10702
1 of 10
drk
1 of 10
Fak
1 of 10
hop
1 of 10
Tie
1 of 10
Wsck
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
Disease Model Summary Ribbon
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 1 )
Allele
Disease
Evidence
References
Src42ACA.UAS
model of  colorectal cancer
CEA
(Cordero et al., 2014)
Potential Models Based on Orthology ( 0 )
Human Ortholog
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 4 )
Disease Associations of Human Orthologs (via DIOPT v7.1 and OMIM)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Homo sapiens (Human)
Gene name
Score
OMIM
OMIM Phenotype
DO term
Complementation?
Transgene?
FRK; fyn related Src family tyrosine kinase
14 of 15
606573
      FYN; FYN proto-oncogene, Src family tyrosine kinase
      7 of 15
      137025
           
          YES1; YES proto-oncogene 1, Src family tyrosine kinase
          6 of 15
          164880
              SRC; SRC proto-oncogene, non-receptor tyrosine kinase
              5 of 15
              190090
              BLK; BLK proto-oncogene, Src family tyrosine kinase
              4 of 15
              191305
              FGR; FGR proto-oncogene, Src family tyrosine kinase
              4 of 15
              164940
                  HCK; HCK proto-oncogene, Src family tyrosine kinase
                  4 of 15
                  142370
                      LCK; LCK proto-oncogene, Src family tyrosine kinase
                      4 of 15
                      153390
                        LYN; LYN proto-oncogene, Src family tyrosine kinase
                        4 of 15
                        165120
                            PTK6; protein tyrosine kinase 6
                            3 of 15
                            602004
                                SRMS; src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites
                                3 of 15
                                617797
                                    Functional Complementation Data
                                    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
                                    Dmel gene
                                    Ortholog showing functional complementation
                                    Supporting References
                                    Src42A
                                    Hsap\MATK
                                    (Cordero et al., 2014)
                                    Interactions
                                    Summary of Physical Interactions
                                    esyN Network Diagram
                                    Show neighbor-neighbor interactions:
                                    Select Layout:
                                    Legend:
                                    Protein
                                    RNA
                                    Selected Interactor(s)
                                    Interactions Browser
                                    View in Interactions Browser
                                    Please see the Physical Interaction reports below for full details
                                    protein-protein
                                    Physical Interaction
                                    Assay
                                    References
                                    Src42A
                                    enzymatic study, western blot, autoradiography
                                    (Pedraza et al., 2004, Stewart et al., 2003, Muda et al., 2002)
                                    Src42A - Akap200
                                    anti tag coimmunoprecipitation, peptide massfingerprinting
                                    (Friedman et al., 2011)
                                    Src42A - Arc1
                                    anti tag coimmunoprecipitation, peptide massfingerprinting
                                    (Friedman et al., 2011)
                                    Src42A - Cad96Ca
                                    pull down, anti tag western blot, two hybrid
                                    (Tsarouhas et al., 2014)
                                    Src42A - CadN
                                    pull down, anti tag western blot
                                    (Pütz, 2019)
                                    Src42A - Csk
                                    enzymatic study, western blot, autoradiography
                                    (Pedraza et al., 2004, Stewart et al., 2003)
                                    Src42A - Dscam1
                                    enzymatic study, autoradiography
                                    (Muda et al., 2002)
                                    Src42A - Egfr
                                    two hybrid
                                    (Bianco et al., 2007)
                                    Src42A - Hrb87F
                                    anti tag coimmunoprecipitation, peptide massfingerprinting
                                    (Friedman et al., 2011)
                                    Src42A - Hsp83
                                    anti tag coimmunoprecipitation, peptide massfingerprinting
                                    (Friedman et al., 2011)
                                    Src42A - Pvr
                                    two hybrid, anti tag coimmunoprecipitation, peptide massfingerprinting
                                    (Friedman et al., 2011, Bianco et al., 2007)
                                    Src42A - Sos
                                    anti tag coimmunoprecipitation, peptide massfingerprinting
                                    (Friedman et al., 2011)
                                    Src42A - baz
                                    anti tag coimmunoprecipitation, anti tag western blot
                                    (Sotillos et al., 2013)
                                    Src42A - cnk
                                    anti bait coimmunoprecipitation, western blot, anti tag coimmunoprecipitation, pull down
                                    (Laberge et al., 2005)
                                    Src42A - dock
                                    enzymatic study, autoradiography
                                    (Muda et al., 2002)
                                    Src42A - smash
                                    anti tag coimmunoprecipitation, anti tag western blot
                                    (Beati et al., 2018)
                                    Summary of Genetic Interactions
                                    esyN Network Diagram
                                    esyN Network Key:
                                    Suppression
                                    Enhancement
                                    View in Interactions Browser
                                    Please look at the allele data for full details of the genetic interactions
                                    Starting gene(s)
                                    Interaction type
                                    Interacting gene(s)
                                    Reference
                                    Src42A
                                    suppressible
                                    14-3-3ζ
                                    (Zhang et al., 1999)
                                    Src42A
                                    enhanceable
                                    arm
                                    (Takahashi et al., 2005)
                                    Src42A
                                    suppressible
                                    boss
                                    (Takahashi et al., 1996)
                                    Src42A
                                    suppressible
                                    bowl
                                    (Zhang et al., 1999)
                                    Src42A
                                    enhanceable
                                    bsk
                                    (Tateno et al., 2000)
                                    Src42A
                                    enhanceable
                                    Btk29A
                                    (Tateno et al., 2000)
                                    Src42A
                                    suppressible
                                    cnk
                                    (Zhang et al., 1999)
                                    Src42A
                                    suppressible
                                    Cortactin
                                    (Somogyi and Rorth, 2004)
                                    Src42A
                                    suppressible
                                    Csk
                                    (Pedraza et al., 2004)
                                    Src42A
                                    enhanceable
                                    Csk
                                    (Pedraza et al., 2004)
                                    Src42A
                                    suppressible
                                    csw
                                    (Takahashi et al., 1996)
                                    Src42A
                                    suppressible
                                    drk
                                    (Zhang et al., 1999, Takahashi et al., 1996)
                                    Src42A
                                    suppressible
                                    Dsor1
                                    (Takahashi et al., 1996)
                                    Src42A
                                    suppressible
                                    Egfr
                                    (Cordero et al., 2014, Zhang et al., 1999)
                                    Src42A
                                    enhanceable
                                    FER
                                    (Murray et al., 2006)
                                    Src42A
                                    enhanceable
                                    hep
                                    (Tateno et al., 2000)
                                    Btk29A|Src42A
                                    suppressible
                                    Jra
                                    (Tateno et al., 2000)
                                    Src42A
                                    suppressible
                                    mbt
                                    (Pütz, 2019)
                                    Src42A
                                    enhanceable
                                    pan
                                    (Shindo et al., 2008)
                                    Src42A
                                    suppressible
                                    puc
                                    (Tateno et al., 2000)
                                    Src42A
                                    suppressible
                                    Raf
                                    (Takahashi et al., 1996)
                                    Src42A
                                    suppressible
                                    Ras85D
                                    (Cordero et al., 2014, Zhang et al., 1999, Takahashi et al., 1996)
                                    Src42A
                                    suppressible
                                    Ret
                                    (Perea et al., 2017)
                                    Src42A
                                    suppressible
                                    rho
                                    (Zhang et al., 1999)
                                    Src42A
                                    suppressible
                                    rl
                                    (Zhang et al., 1999)
                                    Src42A
                                    suppressible
                                    S
                                    (Zhang et al., 1999)
                                    Src42A
                                    suppressible
                                    Ser
                                    (Zhang et al., 1999)
                                    Src42A
                                    suppressible
                                    sev
                                    (Takahashi et al., 1996)
                                    Src42A
                                    enhanceable
                                    shg
                                    (Shindo et al., 2008, Takahashi et al., 2005)
                                    Src42A
                                    suppressible
                                    shg
                                    (Shindo et al., 2008)
                                    Src42A
                                    suppressible
                                    Sos
                                    (Zhang et al., 1999, Takahashi et al., 1996)
                                    Src42A
                                    suppressible
                                    spi
                                    (Zhang et al., 1999)
                                    Src42A
                                    enhanceable
                                    Src64B
                                    (O'Donnell and Bashaw, 2013, Shindo et al., 2008, Takahashi et al., 2005)
                                    Stat92E|Src42A
                                    enhanceable
                                    Src64B
                                    (Sotillos et al., 2013)
                                    Src42A
                                    suppressible
                                    Stat92E
                                    (Cordero et al., 2014)
                                    Src42A
                                    suppressible
                                    Su(H)
                                    (Zhang et al., 1999)
                                    Src42A
                                    suppressible
                                    Su(SuRaf1)1
                                    (Zhang et al., 1999)
                                    Src42A
                                    suppressible
                                    Su(SuRaf1)2
                                    (Zhang et al., 1999)
                                    Src42A
                                    suppressible
                                    Su(SuRaf1)10
                                    (Zhang et al., 1999)
                                    Src42A
                                    suppressible
                                    Su(SuRaf1)11
                                    (Zhang et al., 1999)
                                    Src42A
                                    suppressible
                                    Su(SuRaf1)12
                                    (Zhang et al., 1999)
                                    Src42A
                                    suppressible
                                    Su(SuRaf1)19-2
                                    (Zhang et al., 1999)
                                    Src42A
                                    suppressible
                                    Su(SuRaf1)A2-1
                                    (Zhang et al., 1999)
                                    Src42A
                                    suppressible
                                    Su(SuRaf1)IV
                                    (Zhang et al., 1999)
                                    Src42A
                                    suppressible
                                    Su(tor)2-68-20
                                    (Zhang et al., 1999)
                                    Src42A
                                    suppressible
                                    Su(tor)2-113-31
                                    (Zhang et al., 1999)
                                    Src42A
                                    suppressible
                                    Su(tor)2-164-14
                                    (Zhang et al., 1999)
                                    Src42A
                                    suppressible
                                    Su(tor)2-321
                                    (Zhang et al., 1999)
                                    Src42A
                                    suppressible
                                    Su(tor)278-22
                                    (Zhang et al., 1999)
                                    Starting gene(s)
                                    Interaction type
                                    Interacting gene(s)
                                    Reference
                                    Apc
                                    suppressible
                                    Src42A
                                    (Cordero et al., 2014)
                                    Btk29A
                                    enhanceable
                                    Src42A
                                    (Chandrasekaran and Beckendorf, 2005, Tateno et al., 2000)
                                    bwk
                                    suppressible
                                    Src42A
                                    (Tran and Berg, 2003)
                                    bwk
                                    enhanceable
                                    Src42A
                                    (Tran and Berg, 2003)
                                    Csk
                                    suppressible
                                    Src42A
                                    (Read et al., 2004)
                                    DAAM
                                    suppressible
                                    Src42A
                                    (Matusek et al., 2006)
                                    DAAM
                                    enhanceable
                                    Src42A
                                    (Matusek et al., 2006)
                                    Dsor1
                                    suppressible
                                    Src42A
                                    (Lu and Li, 1999, Lu et al., 1994)
                                    Fak
                                    enhanceable
                                    Src42A|Src64B
                                    (Tsai et al., 2008)
                                    fra
                                    suppressible
                                    Src42A|Src64B
                                    (O'Donnell and Bashaw, 2013)
                                    fra
                                    suppressible
                                    Src42A
                                    (O'Donnell and Bashaw, 2013)
                                    ksr::tor
                                    suppressible
                                    Src42A
                                    (Therrien et al., 2000, Therrien et al., 1998)
                                    l(2)gl
                                    suppressible
                                    Src42A
                                    (Ma et al., 2013)
                                    mbt
                                    suppressible
                                    Src42A
                                    (Pütz, 2019)
                                    Raf::tor
                                    enhanceable
                                    Src42A
                                    (Lu and Li, 1999)
                                    Raf
                                    suppressible
                                    Src42A
                                    (Therrien et al., 2000, Zhang and Lu, 2000, Lu and Li, 1999, Zhang et al., 1999, Lu et al., 1994)
                                    Ras85D
                                    suppressible
                                    Src42A
                                    (Ma et al., 2013, Lu and Li, 1999)
                                    Ras85D
                                    enhanceable
                                    Src42A
                                    (Laberge et al., 2005, Therrien et al., 2000, Lu and Li, 1999)
                                    Ras85D|l(2)gl
                                    suppressible
                                    Src42A
                                    (Ma et al., 2013)
                                    Ret
                                    suppressible
                                    Src42A
                                    (Perea et al., 2017, Read et al., 2005)
                                    Sos
                                    suppressible
                                    Src42A
                                    (Lu and Li, 1999)
                                    External Data
                                    Linkouts
                                    DroID - A comprehensive database of gene and protein interactions.
                                    MIST (genetic) - An integrated Molecular Interaction Database
                                    MIST (protein-protein) - An integrated Molecular Interaction Database
                                    Pathways
                                    Signaling Pathways (FlyBase)
                                    Negative Regulators of EGFR Signaling Pathway -
                                    Negative regulators of Epidermal Growth Factor Receptor signaling down-regulate the pathway, suppressing the activation of ERK kinase (rl) or acting on downstream effectors.
                                    Positive Regulators of EGFR Signaling Pathway -
                                    Positive regulators of Epidermal Growth Factor Receptor signaling up-regulate the pathway, enhancing the activation of ERK kinase (rl) or acting on downstream effectors.
                                    Positive Regulators of Sevenless Signaling Pathway -
                                    Positive regulators of Sevenless signaling up-regulate the pathway, promoting cell fate to that of an R7 photoreceptor. (Adapted from FBrf0127283 and FBrf0221727).
                                    Metabolic Pathways
                                    External Data
                                    Linkouts
                                    KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
                                    Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                                    Genomic Location and Detailed Mapping Data
                                    Chromosome (arm)
                                    2R
                                    Recombination map

                                    2-55

                                    Cytogenetic map
                                    42A6-42A7
                                    Sequence location
                                    2R:5,981,844..6,012,795 [+]
                                    FlyBase Computed Cytological Location
                                    Cytogenetic map
                                    Evidence for location
                                    42A6-42A7
                                    Limits computationally determined from genome sequence between P{PZ}l(2)0985109851&P{lacW}Src42Ak10108 and P{lacW}l(2)k09848k09848&P{EP}EP407
                                    Experimentally Determined Cytological Location
                                    Cytogenetic map
                                    Notes
                                    References
                                    41B-41C
                                    (Saigo, 1994.11.17)
                                    42A1-42A2
                                    (determined by in situ hybridisation)
                                    (Spradling et al., 1999)
                                    42A1-42A4
                                    (Lu and Li, 1998)
                                    41B-1C
                                    (determined by in situ hybridisation)
                                    (Takahashi et al., 1996)
                                    42A1-42A2
                                    42A4--5
                                    (BDGP Project Members, 1994-1999)
                                    Experimentally Determined Recombination Data
                                    Location

                                    2-55

                                    (FlyBase, 2016)

                                    2-55.8

                                    (Comeron et al., 2012)

                                    2-55.8 +/- 0.2

                                    (Lu and Li, 1999)

                                    2-

                                    (Saigo, 1994.11.17)

                                    2-55 +/- 1

                                    (Lu et al., 1994)
                                    Left of (cM)
                                    Right of (cM)
                                    Notes
                                    Stocks and Reagents
                                    Stocks (31)
                                    Genomic Clones (33)
                                    cDNA Clones (106)
                                     

                                    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

                                    cDNA clones, fully sequences
                                    BDGP DGC clones
                                    Other clones
                                    Drosophila Genomics Resource Center cDNA clones

                                    For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                                    cDNA Clones, End Sequenced (ESTs)
                                    BDGP DGC clones
                                    Other clones
                                    RNAi and Array Information
                                    Linkouts
                                    GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                                    Antibody Information
                                    Laboratory Generated Antibodies
                                     

                                    polyclonal

                                    (Shindo et al., 2008)
                                    Commercially Available Antibodies
                                     
                                    Other Information
                                    Relationship to Other Genes
                                    Source for database identify of

                                    Source for identity of: Src42A CG7873

                                    (Kodira, 1999.11)
                                    Source for database merge of

                                    Source for merge of: Src42A l(2)k10108 Su(phl)1

                                    (Therrien et al., 1998)

                                    Source for merge of: Src42A CG14471

                                    (FlyBase Genome Annotators, 2012)
                                    Additional comments

                                    Annotations CG7873 and CG14471 merged as CG44128 in release 5.47 of the genome annotation. Merge supported by RNA-seq junction data.

                                    (FlyBase Genome Annotators, 2012)

                                    Identified by PCR fragment; relationship to other protein tyrosine kinase genes not known.

                                    (Oates, 1997.11.10)
                                    Other Comments

                                    ChEST reveals this is a target of Mef2.

                                    (Junion et al., 2005)

                                    Src42A functions in epidermal closure during both embryogenesis and metamorphosis, where it regulates bsk.

                                    (Tateno et al., 2000)

                                    Src42A defines a negative regulatory pathway parallel to Ras85D in the receptor tyrosine kinase signaling cascade.

                                    (Lu and Li, 1999)

                                    Nucleotide sequence analysis and analysis of phenotypes of gain of function and dominant negative mutations in the developing retina and embryos suggests that Src42A is the closest relative of vertebrate c-src found so far in Drosophila and may play an essential role in cytoskeleton organisation and cell-cell contacts in development.

                                    (Takahashi et al., 1996)

                                    Suppressor functions by up-regulating phl signalling pathways and affect the signalling pathway mediated by Egfr.

                                    (Lu et al., 1994)
                                    Origin and Etymology
                                    Discoverer
                                    Etymology
                                    Identification
                                    External Crossreferences and Linkouts ( 71 )
                                    Sequence Crossreferences
                                    NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                                    GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                                    GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                                    RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                                    UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
                                    UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                                    Other crossreferences
                                    BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
                                    Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                                    Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                                    Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                                    GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                                    iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                                    InterPro - A database of protein families, domains and functional sites
                                    KEGG Genes - Molecular building blocks of life in the genomic space.
                                    SignaLink - A signaling pathway resource with multi-layered regulatory networks.
                                    Linkouts
                                    DroID - A comprehensive database of gene and protein interactions.
                                    Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
                                    KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
                                    MIST (genetic) - An integrated Molecular Interaction Database
                                    MIST (protein-protein) - An integrated Molecular Interaction Database
                                    Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                                    Synonyms and Secondary IDs (37)
                                    Reported As
                                    Symbol Synonym
                                    CG14471
                                    CG44128
                                    (FlyBase Genome Annotators, 2012, Ni et al., 2010.12.1)
                                    CG7873
                                    (Hosono et al., 2015, Christis and Munro, 2012, Keleman et al., 2009.8.5, Chen et al., 2008, Kanuka et al., 2005, Morrison et al., 2000)
                                    DSrc42A
                                    (Xia and Karin, 2004)
                                    Dm SRC41
                                    (Gibson and Spring, 1998)
                                    DmHD-29
                                    (Oates et al., 1998, Oates, 1997.11.10)
                                    Dsrc41
                                    (Lu and Johnston, 2013, Lu and Li, 1999, Palmer et al., 1999, Lu, 1998.3.10, Takahashi et al., 1996, Saigo, 1994.11.17)
                                    Dsrc42A
                                    (Farazi et al., 2001, Lu, 1998.3.10, Lu and Li, 1998, Zhang and Lu, 1998)
                                    Dtk5
                                    HD-29
                                    SK2-4
                                    (Therrien et al., 2000, Therrien et al., 1998)
                                    SRC 42A
                                    (Morrison et al., 2000)
                                    SRC42A
                                    (Matusek et al., 2005)
                                    Src
                                    (Das et al., 2018, Das et al., 2013, Hirabayashi et al., 2013, Desprat et al., 2008, Tountas and Fortini, 2007, Edgar, 2006, Petit et al., 2002, Vincent and Magee, 2002)
                                    Src41
                                    (Ohno, 1999)
                                    Src42
                                    (Pütz, 2019, Yang et al., 2019, Cordero et al., 2014, Robbins et al., 2014, Harris and Beckendorf, 2007, Laberge et al., 2005, Worby et al., 2002)
                                    Src42A
                                    (Feuillette et al., 2020, Moreno et al., 2019, Tsarouhas et al., 2019, Beati et al., 2018, Courgeon et al., 2018, Lee et al., 2018, Mortensen et al., 2018, Poon et al., 2018, Richardson and Portela, 2018, Ashton-Beaucage and Therrien, 2017, Brüser and Bogdan, 2017, Hayashi and Dong, 2017, Houtz et al., 2017, Sun et al., 2017, Transgenic RNAi Project members, 2017-, Clandinin and Owens, 2016-, Gene Disruption Project members, 2016-, Hoi et al., 2016, Ma et al., 2016, Meehan et al., 2016, Öztürk-Çolak et al., 2016, Öztürk-Çolak et al., 2016, Spring et al., 2016, Aradska et al., 2015, Freeman, 2015, Luo et al., 2015, Ashwal-Fluss et al., 2014, Bülow et al., 2014, Dong et al., 2014, Fernández et al., 2014, Lee et al., 2014, Macagno et al., 2014, Santhanam et al., 2014, Sopko et al., 2014, Tutor et al., 2014, Beckett et al., 2013, Carter, 2013, Ma et al., 2013, Mbodj et al., 2013, O'Donnell and Bashaw, 2013, Read et al., 2013, Ríos-Barrera and Riesgo-Escovar, 2013, Sotillos et al., 2013, Bulgakova et al., 2012, Fang and Bonini, 2012, Förster and Luschnig, 2012, Murray et al., 2012, Nelson et al., 2012, Di Stefano et al., 2011, Franco et al., 2011, Friedman et al., 2011, Friedman et al., 2011, Juarez et al., 2011, Csiszar et al., 2010, Singh et al., 2010, Tikhmyanova et al., 2010, Debat et al., 2009, Langton et al., 2009, Tan et al., 2009, Chen et al., 2008, Desprat et al., 2008, Shindo et al., 2008, Tsai et al., 2008, Wouda et al., 2008, Ziegenfuss et al., 2008, Bianco et al., 2007, Kaltenbach et al., 2007, Langton et al., 2007, Dworkin and Gibson, 2006, Matusek et al., 2006, Murray et al., 2006, Sandmann et al., 2006, Harrison et al., 2005, Kanuka et al., 2005, Muda et al., 2002, Pickeral et al., 2000)
                                    Src42a
                                    (Williamson and Vale, 2018, Matsubayashi and Millard, 2016, Flourakis et al., 2015, Kohlmaier et al., 2015, Doherty et al., 2014, McPhee et al., 2010)
                                    Su(D-raf)1
                                    (Lu et al., 1994)
                                    Su(Raf)1
                                    (Lu and Li, 1999)
                                    Su(phl)1
                                    (Lu et al., 1994)
                                    Su1
                                    (Lu and Li, 1998)
                                    Tk5
                                    dSrc
                                    (Langton et al., 2007)
                                    dSrc42A
                                    (Vidal et al., 2007)
                                    dtk-5
                                    (Takahashi et al., 1996)
                                    dtk5
                                    (Oates et al., 1998, Shishido, 1991.12.2, Shishido et al., 1991)
                                    l(2)k10108
                                    src
                                    (Johnson Hamlet and Perkins, 2000)
                                    src42
                                    (Gu and Gu, 2003, Wills et al., 2002)
                                    src42A
                                    (Lu et al., 2017, Vanderploeg and Jacobs, 2017, Levinson and Cagan, 2016, Testa and Dworkin, 2016, Tsarouhas et al., 2014, Xue et al., 2007, Dworkin and Gibson., 2006, Jordan et al., 2005)
                                    src42a
                                    (McPhee et al., 2010)
                                    Name Synonyms
                                    Src oncogene at 42A
                                    (Nakayama et al., 2014, Kaltenbach et al., 2007)
                                    Src42A
                                    (Juarez, 2016)
                                    Suppressor of pole hole
                                    (Lu et al., 1994)
                                    Suppressor of raf-like-oncogene
                                    (Lu et al., 1994)
                                    Tyrosine kinase 5
                                    src oncogene at 42A
                                    (McPhee et al., 2010)
                                    Secondary FlyBase IDs
                                    • FBgn0004603
                                    • FBgn0010284
                                    • FBgn0014884
                                    • FBgn0021964
                                    • FBgn0022795
                                    • FBgn0024932
                                    • FBgn0033049
                                    Datasets (1)
                                    Study focus (1)
                                    Experimental Role
                                    Project
                                    Project Type
                                    Title
                                    • bait_protein
                                    RTK-Ras-ERK_interaction_map
                                    Interaction map generated by purification of receptor tyrosine kinase pathway factors, with identification of copurifying proteins by mass spectrometry.
                                    References (225)