Src, Dsrc41, Src42, Dsrc42A, dtk5
Src homolog - a protein tyrosine kinase with SH3 and SH2 domains - essential for cell-cell matching during dorsal closure - involved in adherins junction stabilization
Please see the JBrowse view of Dmel\Src42A for information on other features
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Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.47
3.0 (northern blot)
None of the polypeptides share 100% sequence identity.
517 (aa)
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Src42A using the Feature Mapper tool.
Comment: maternally deposited
Src42A transcripts are first detected in stage 2-3 embryos. They are uniformly expressed in the embryo until the end of germ band retraction. At stages 13-16, high expression is observed in visceral mesoderm, hindgut, brain, anal pads, and ventral ganglion. In third instar larvae, expression is strong in the CNS. In addition, almost all cells in the eye-antennal, wing and leg discs express Src42A.
Comment: pSrc distribution
Comment: pSrc distribution
Comment: pSrc distribution
Comment: pSrc distribution
Comment: pSrc distribution
Comment: pSrc distribution
Comment: pSrc distribution
GBrowse - Visual display of RNA-Seq signals
View Dmel\Src42A in GBrowse 22-55
2-55
2-55.8
2-55.8 +/- 0.2
2-55 +/- 1
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for identity of: Src42A CG7873
Source for merge of: Src42A l(2)k10108 Su(phl)1
Source for merge of: Src42A CG14471
Annotations CG7873 and CG14471 merged as CG44128 in release 5.47 of the genome annotation. Merge supported by RNA-seq junction data.
Identified by PCR fragment; relationship to other protein tyrosine kinase genes not known.
ChEST reveals this is a target of Mef2.
Nucleotide sequence analysis and analysis of phenotypes of gain of function and dominant negative mutations in the developing retina and embryos suggests that Src42A is the closest relative of vertebrate c-src found so far in Drosophila and may play an essential role in cytoskeleton organisation and cell-cell contacts in development.