Src, Src42, Dsrc41, Dsrc42A, dtk5
AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.47
None of the polypeptides share 100% sequence identity.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Src42A using the Feature Mapper tool.
Src42A transcripts are observe throughout the embryonic ventral nerve cord and gut. The Src42A transcript distribution overlaps with drl in the ventral nerve cord in the anterior part of each segment. Both are expressed in axonal projections.
Src42A transcripts are first detected in stage 2-3 embryos. They are uniformly expressed in the embryo until the end of germ band retraction. At stages 13-16, high expression is observed in visceral mesoderm, hindgut, brain, anal pads, and ventral ganglion. In third instar larvae, expression is strong in the CNS. In addition, almost all cells in the eye-antennal, wing and leg discs express Src42A.
GBrowse - Visual display of RNA-Seq signalsView Dmel\Src42A in GBrowse 2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for identity of: Src42A CG7873
Nucleotide sequence analysis and analysis of phenotypes of gain of function and dominant negative mutations in the developing retina and embryos suggests that Src42A is the closest relative of vertebrate c-src found so far in Drosophila and may play an essential role in cytoskeleton organisation and cell-cell contacts in development.