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General Information
Symbol
Dmel\Nrg
Species
D. melanogaster
Name
Neuroglian
Annotation Symbol
CG1634
Feature Type
FlyBase ID
FBgn0264975
Gene Model Status
Stock Availability
Gene Snapshot
Neuroglian (Nrg) encodes an immunoglobulin domain-containing cell adhesion molecule that mediates cell-cell adhesion by forming homo- or heterophilic interactions. The long isoform of the product of Nrg is neuron specific and plays roles in neurite outgrowth, axon guidance and synapse formation. The short isoform of the product of Nrg contributes to the formation of septate junctions in epithelial cells. [Date last reviewed: 2019-09-26]
Also Known As
ceb, central brain deranged, Nrg180, CT4318, l(1)G0099
Key Links
Genomic Location
Cytogenetic map
Sequence location
X:8,517,373..8,555,170 [+]
Recombination map
1-23
Sequence
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
Function
GO Summary Ribbons
Protein Family (UniProt)
-
Molecular Function (GO)
[Detailed GO annotations]
Experimental Evidence
Predictions / Assertions
-
Summaries
Protein Function (UniProtKB)
The long isoform may play a role in neural and glial cell adhesion in the developing embryo. The short isoform may be a more general cell adhesion molecule involved in other tissues and imaginal disk morphogenesis. Vital for embryonic development. Essential for septate junctions. Septate junctions, which are the equivalent of vertebrates tight junctions, are characterized by regular arrays of transverse structures that span the intermembrane space and form a physical barrier to diffusion. Required for the blood-brain barrier formation.
(UniProt, P20241)
Phenotypic Description (Red Book; Lindsley and Zimm 1992)
ceb: central brain deranged (J.C. Hall)
Extra lobe, in adult brain, of approximately 400 coiled Kenyon-cell fibers next to calyx of mushroom bodies; olfactory learning in adults slightly reduced; memory is normal.
Nrg: Neuroglian
Encodes a protein that is likely to play a role in neural and glial cell adhesion in the developing Drosophila embryo. Widely expressed in the embryo, particularly on the surfaces of a large subset of neurons and glia that interact with and adhere to one another along the dorsal surface of the developing CNS and within the peripheral nerve roots; the protein can be detected along neuronal axons, but not cell bodies. Three polypeptides of 155, 167, and 180 kd are detected on Western blots; deglycosylation experiments reduce these to a single 155 kd band; removal of N-linked high-mannose oligosaccharides causes a shift to about 162 kd. It is also expressed in a number of non-neuronal tissues such as trachea, hindgut, salivary gland and muscle. Recessive alleles are embryonic lethals and show little or no evidence of Neuroglian expression; the overall structure of the CNS and PNS, and in particular the peripheral nerve roots and CNS axon pathways develop in a relatively normal way in lethal embryos.
Summary (Interactive Fly)
IG superfamily - NgCAM related - a cell aggregaton and signaling molecule that transmits the positional value of cell adhesion to the cytoplasmic assembly of ankyrin and spectrin
Gene Model and Products
Number of Transcripts
9
Number of Unique Polypeptides
3

Please see the GBrowse view of Dmel\Nrg or the JBrowse view of Dmel\Nrg for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model
Low-frequency RNA-Seq exon junction(s) not annotated.
Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated
Stage-specific extension of 3' UTRs observed during embryogenesis (FBrf0215804); all variants may not be annotated.
Gene model reviewed during 5.46
Gene model reviewed during 5.55
Sequence Ontology: Class of Gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
FBtr0071207
5247
1239
FBtr0071208
4492
1302
FBtr0071209
5090
1239
FBtr0301762
5059
1239
FBtr0301763
7386
1302
FBtr0301764
5064
1239
FBtr0305914
5403
1309
FBtr0333522
5272
1239
FBtr0333523
5548
1302
Additional Transcript Data and Comments
Reported size (kB)
7.6, 5.7, 5.5 (northern blot)
5.1 (northern blot)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
FBpp0071154
138.4
1239
5.15
FBpp0071155
143.6
1302
5.15
FBpp0089326
138.4
1239
5.15
FBpp0290976
138.4
1239
5.15
FBpp0290977
143.6
1302
5.15
FBpp0290978
138.4
1239
5.15
FBpp0297081
145.5
1309
5.24
FBpp0305702
138.4
1239
5.15
FBpp0305703
143.6
1302
5.15
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

1239 aa isoforms: Nrg-PA, Nrg-PC, Nrg-PD, Nrg-PF, Nrg-PH
1302 aa isoforms: Nrg-PB, Nrg-PE, Nrg-PI
Additional Polypeptide Data and Comments
Reported size (kDa)
1302, 1239 (aa)
180 (kD observed)
1216 (aa); 145-155 (kD predicted)
Comments
Neuron-specific 180kD form.
The core 145-155 kD Nrg protein is glycosylated to produce a 167-180 kD protein. Nrg may play a role in neural and glial adhesion in the developing embryo.
External Data
Subunit Structure (UniProtKB)
Forms a complex with Nrx and Cont.
(UniProt, P20241)
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Nrg using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Gene Ontology (29 terms)
Molecular Function (2 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
inferred from direct assay
Terms Based on Predictions or Assertions (0 terms)
Biological Process (21 terms)
Terms Based on Experimental Evidence (21 terms)
CV Term
Evidence
References
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from direct assay
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
(assigned by UniProt )
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
(assigned by UniProt )
Terms Based on Predictions or Assertions (0 terms)
Cellular Component (6 terms)
Terms Based on Experimental Evidence (6 terms)
CV Term
Evidence
References
colocalizes_with cytoneme
inferred from direct assay
inferred from direct assay
inferred from direct assay
(assigned by UniProt )
inferred from direct assay
inferred from high throughput direct assay
Terms Based on Predictions or Assertions (0 terms)
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
No Assay Recorded
Stage
Tissue/Position (including subcellular localization)
Reference
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
organism

Comment: extended 3' UTR isoform

Comment: reference states >=11-12 hr AEL

northern blot
Stage
Tissue/Position (including subcellular localization)
Reference

Comment: reference states >=9 hr AEL

Additional Descriptive Data
Isoforms of nmo with extended 3' UTRs appear later in embryogenesis. Sequential, phased, 3' UTR lengthening is seen (3' UTR lengthening ocurring in multiple steps during later stages of embryogenesis).
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
No Assay Recorded
Stage
Tissue/Position (including subcellular localization)
Reference
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference

Comment: reference states >=8 hr AEL

central nervous system | restricted

Comment: reference states >=11-12 hr AEL

embryonic/larval hindgut

Comment: reference states >=11-12 hr AEL

embryonic/larval salivary gland

Comment: reference states >=11-12 hr AEL

embryonic/larval trachea

Comment: reference states >=11-12 hr AEL

embryonic/larval muscle system

Comment: reference states >=11-12 hr AEL

adult mushroom body

Comment: applies to longer protein isoform

adult brain | ubiquitous

Comment: applies to longer protein isoform

adult mushroom body gamma-lobe

Comment: applies to longer protein isoform

adult mushroom body alpha-lobe

Comment: applies to longer protein isoform

adult mushroom body beta-lobe

Comment: applies to longer protein isoform

adult mushroom body alpha'-lobe

Comment: applies to longer protein isoform

adult mushroom body beta'-lobe

Comment: applies to longer protein isoform

mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data
Nrg-XP is excluded from the calyx of the larval mushroom body, but not from the lobes.
The long Nrg protein isoform (designated NRG-180) is expressed throughout the third instar larval and adult brain. It is prominent in axons but is also present in cell bodies. In larval, pupal, and adult mushroom bodies, staining is observed in all lobes. High expression levels are observed in the adult gamma and alpha beta lobes. Expression is lower in axons of the alpha'beta' neurons.
Nrg protein is detected in the glial cell membranes in the peripheral nerves, ensheathing the axons and in the axons themselves. In the chordotonal organs, it is detected in the scolopale and cap cells, and in the scolopidial neuron.
In the early prepupal stages before head eversion, tThe neural-specific Nrg180 isoform is expressed by both ocellar pioneer and bristle mechanosensory neurons, but not by the external bristle cells.
Nrg is expressed at the lateral cell contacts of follicle cells in the ovary.
The shorter form of the Nrg protein is expressed in the epidermal cells of the imaginal discs. Since the antibody which detects the short form of Nrg also detects the long form, it is not clear how much of the signal detected is attributable to the short form. Developmental western blots show that the shorter Nrg polypeptide is first unambiguously detected in 8 hour embryos, and is most strongly expressed in 8-12 hour embryos.
The long form of Nrg protein is expressed on the surface of central and peripheral nervous system neurons, and on some PNS support cells. The long form is detected starting at 6 hours of embryogenesis, in one neuron per CNS hemisegment. At 7 hours, CNS expression extends to a 4-5 cell wide longitudinal stripe which prefigures the location of the longitudinal axon tracts. PNS expression is detected by 7 hours. Expression observed in larval imaginal discs is also restricted to neurons. Developmental western blots indicate that the peak of expression for the longer Nrg polypeptide is reached shortly after the peak for the shorter form.
A monoclonal antibody which recognizes both forms of the Nrg protein detects Nrg protein in neurons of the central nervous system and peripheral nervous system of the embryo, as well as in epidermal cells and neurons of third instar larval imaginal discs.
Nrg protein is expressed on neurons and glia in the developing nervous system, and in some non-neuronal tissues including the trachea, hindgut, salivary gland and muscle.
Marker for
Subcellular Localization
CV Term
Evidence
References
colocalizes_with cytoneme
inferred from direct assay
inferred from direct assay
inferred from direct assay
(assigned by UniProt )
inferred from direct assay
inferred from high throughput direct assay
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Nrg in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Images
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 25 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 42 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Nrg
Transgenic constructs containing regulatory region of Nrg
Deletions and Duplications ( 13 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
Sterility
Allele
Other Phenotypes
Allele
Phenotype manifest in
Allele
axon & mechanosensory neuron & adult head | conditional ts
axon & nerve
axon & ocellus sensory structure | conditional ts
cell cortex & cortical cytoskeleton
dendrite & vesicle
dorsal multidendritic neuron ddaD & axon
dorsal multidendritic neuron ddaD & axon | conditional ts
dorsal multidendritic neuron ddaD & dendritic tree
dorsal multidendritic neuron ddaD & dendritic tree, with Scer\GAL4repo
dorsal multidendritic neuron ddaD & dendritic tree | conditional ts
dorsal multidendritic neuron ddaE & axon
dorsal multidendritic neuron ddaE & axon, with Scer\GAL4IG1-1, Scer\GAL4repo
dorsal multidendritic neuron ddaE & axon, with Scer\GAL4repo
dorsal multidendritic neuron ddaE & axon | conditional ts
dorsal multidendritic neuron ddaE & axon | somatic clone
dorsal multidendritic neuron ddaE & dendritic tree
dorsal multidendritic neuron ddaE & dendritic tree (with Nrgl7), with Scer\GAL4IG1-1
dorsal multidendritic neuron ddaE & dendritic tree (with NrgUAS.Tag:HA), with Scer\GAL4IG1-1
dorsal multidendritic neuron ddaE & dendritic tree | conditional ts
embryonic epidermis & pleated septate junction
embryonic ganglionic branch & embryonic tracheole
embryonic salivary gland & epithelial cell
giant fibers & synapse
lateral cord surface glia & nucleus
mitochondrion & synapse
scolopidium & abdominal lateral pentascolopidial chordotonal organ lch5
septate junction & peripheral glial cell
wing & sensory neuron | ectopic, with Scer\GAL4MS1075
wing margin & axon tract, with Scer\GAL4Bx-MS1096
wing vein L1 & wing nerve, with Scer\GAL4MS1075
wing vein L3 & wing nerve, with Scer\GAL4MS1075
Orthologs
Human Orthologs (via DIOPT v7.1)
Homo sapiens (Human) (20)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
12 of 15
Yes
Yes
11 of 15
Yes
No
10 of 15
Yes
No
 
 
9 of 15
Yes
No
1 of 15
No
No
1 of 15
No
No
 
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
Yes
No
1 of 15
Yes
No
1 of 15
Yes
No
1 of 15
Yes
No
1 of 15
Yes
No
1 of 15
No
Yes
1 of 15
Yes
No
1 of 15
Yes
No
1 of 15
No
No
1 of 15
No
No
Model Organism Orthologs (via DIOPT v7.1)
Mus musculus (laboratory mouse) (17)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
11 of 15
Yes
Yes
10 of 15
Yes
No
10 of 15
Yes
No
 
 
10 of 15
No
Yes
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
Yes
No
1 of 15
Yes
No
1 of 15
Yes
No
1 of 15
Yes
No
1 of 15
No
Yes
1 of 15
Yes
No
1 of 15
Yes
No
1 of 15
No
No
Rattus norvegicus (Norway rat) (13)
9 of 13
Yes
Yes
8 of 13
No
Yes
 
 
7 of 13
No
Yes
2 of 13
No
Yes
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
Yes
1 of 13
No
Yes
1 of 13
No
No
Xenopus tropicalis (Western clawed frog) (9)
9 of 12
Yes
Yes
8 of 12
No
Yes
7 of 12
No
Yes
1 of 12
No
No
1 of 12
No
No
1 of 12
No
No
1 of 12
No
Yes
1 of 12
No
Yes
1 of 12
No
Yes
Danio rerio (Zebrafish) (19)
10 of 15
Yes
Yes
10 of 15
Yes
Yes
10 of 15
Yes
Yes
8 of 15
No
Yes
8 of 15
No
Yes
6 of 15
Yes
No
4 of 15
No
Yes
2 of 15
No
Yes
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
Yes
1 of 15
No
Yes
1 of 15
No
No
1 of 15
No
Yes
1 of 15
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (5)
13 of 15
Yes
Yes
5 of 15
No
Yes
1 of 15
No
No
1 of 15
No
Yes
1 of 15
No
No
Arabidopsis thaliana (thale-cress) (0)
No records found.
Saccharomyces cerevisiae (Brewer's yeast) (0)
No records found.
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG091900XC )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila melanogaster
fruit fly
Drosophila suzukii
Spotted wing Drosophila
Drosophila simulans
Drosophila sechellia
Drosophila erecta
Drosophila yakuba
Drosophila ananassae
Drosophila pseudoobscura pseudoobscura
Drosophila persimilis
Drosophila willistoni
Drosophila virilis
Drosophila mojavensis
Drosophila grimshawi
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091500SA )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Musca domestica
House fly
Glossina morsitans
Tsetse fly
Lucilia cuprina
Australian sheep blowfly
Mayetiola destructor
Hessian fly
Aedes aegypti
Yellow fever mosquito
Anopheles darlingi
American malaria mosquito
Anopheles gambiae
Malaria mosquito
Culex quinquefasciatus
Southern house mosquito
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W00JZ )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bombyx mori
Silkmoth
Bombyx mori
Silkmoth
Danaus plexippus
Monarch butterfly
Heliconius melpomene
Postman butterfly
Apis florea
Little honeybee
Apis mellifera
Western honey bee
Bombus impatiens
Common eastern bumble bee
Bombus terrestris
Buff-tailed bumblebee
Linepithema humile
Argentine ant
Megachile rotundata
Alfalfa leafcutting bee
Nasonia vitripennis
Parasitic wasp
Dendroctonus ponderosae
Mountain pine beetle
Tribolium castaneum
Red flour beetle
Pediculus humanus
Human body louse
Rhodnius prolixus
Kissing bug
Rhodnius prolixus
Kissing bug
Rhodnius prolixus
Kissing bug
Rhodnius prolixus
Kissing bug
Cimex lectularius
Bed bug
Acyrthosiphon pisum
Pea aphid
Acyrthosiphon pisum
Pea aphid
Zootermopsis nevadensis
Nevada dampwood termite
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X00J4 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Strigamia maritima
European centipede
Strigamia maritima
European centipede
Ixodes scapularis
Black-legged tick
Ixodes scapularis
Black-legged tick
Stegodyphus mimosarum
African social velvet spider
Stegodyphus mimosarum
African social velvet spider
Tetranychus urticae
Two-spotted spider mite
Daphnia pulex
Water flea
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0323 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Paralogs
Paralogs (via DIOPT v7.1)
Drosophila melanogaster (Fruit fly) (17)
2 of 10
1 of 10
1 of 10
1 of 10
1 of 10
1 of 10
1 of 10
1 of 10
1 of 10
1 of 10
1 of 10
1 of 10
1 of 10
1 of 10
1 of 10
1 of 10
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
Disease Model Summary Ribbon
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Allele
Disease
Evidence
References
Potential Models Based on Orthology ( 2 )
Human Ortholog
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 1 )
Allele
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease Associations of Human Orthologs (via DIOPT v7.1 and OMIM)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Functional Complementation Data
Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
Dmel gene
Ortholog showing functional complementation
Supporting References
Interactions
Summary of Physical Interactions
Summary of Genetic Interactions
esyN Network Diagram
esyN Network Key:
Suppression
Enhancement

Please look at the allele data for full details of the genetic interactions
Starting gene(s)
Interaction type
Interacting gene(s)
Reference
Starting gene(s)
Interaction type
Interacting gene(s)
Reference
External Data
Subunit Structure (UniProtKB)
Forms a complex with Nrx and Cont.
(UniProt, P20241 )
Linkouts
DroID - A comprehensive database of gene and protein interactions.
MIST (genetic) - An integrated Molecular Interaction Database
MIST (protein-protein) - An integrated Molecular Interaction Database
Pathways
Genomic Location and Detailed Mapping Data
Chromosome (arm)
X
Recombination map
1-23
Cytogenetic map
Sequence location
X:8,517,373..8,555,170 [+]
FlyBase Computed Cytological Location
Cytogenetic map
Evidence for location
7F2-7F4
Limits computationally determined from genome sequence between P{EP}CG1632EP1583 and P{EP}MoeEP1652
Experimentally Determined Cytological Location
Cytogenetic map
Notes
References
7F1-7F4
(determined by in situ hybridisation)
7F-7F
(determined by in situ hybridisation)
7F1-8A5
7F1-7F1
(determined by in situ hybridisation)
Experimentally Determined Recombination Data
Left of (cM)
Right of (cM)
Notes
Stocks and Reagents
Stocks (26)
Genomic Clones (17)
 

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (92)
 

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequences
BDGP DGC clones
Other clones
Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

cDNA Clones, End Sequenced (ESTs)
RNAi and Array Information
Linkouts
GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
Antibody Information
Laboratory Generated Antibodies
Commercially Available Antibodies
 
Developmental Studies Hybridoma Bank - Monoclonal antibodies for use in research
Other Information
Relationship to Other Genes
Source for database identify of
Source for identity of: Nrg CG1634
Source for database merge of
Source for merge of: Nrg l(1)G0099 l(1)G0413
Source for merge of: Nrg ceb
Source for merge of: ibx fs(1)M72
Source for merge of: Nrg ibx
Additional comments
Other Comments
Nrg has an endogenous pre- and postsynaptic function in giant synapse formation. The intracellular domain of Nrg is indispensable for giant-synapse formation.
One of 42 Drosophila genes identified as being most likely to reveal molecular and cellular mechanisms of nervous system development or plasticity relevant to human Mental Retardation disorders.
Nrg appears to act as a heterophilic ligand and receptor of ed which in turn antagonises Egfr signaling.
The probability of mating is reduced in ibx mutant females and the frequency of rejection behaviour towards courting males is increased.
Inhibition of cell adhesion by ethanol in Nrg expressing cells cannot be explained by a simple direct effect of ethanol on the adhesion activity of Nrg.
Interaction between Ank and Nrg molecules occurs by a mechanism that couples the positional information of cell adhesion to the polar assembly of Ank.
elav regulates neural expression of Nrg by promoting the formation of the neural-specific alternative splice variant of Nrg.
Nrg mutant females show and abnormal response to the injection of SP. Nrg mutants affect mushroom bodies.
Nrg is required for central complex formation.
Mutations causing structural defects in the adult central complex also alter larval behavioural phenotypes.
Three polypeptides of 155, 167 and 180kD are detected on Western blots; deglycosylation experiments reduce these to a single 155kD band; removal of N-linked high-mannose oligosaccharides causes a shift to about 162kD.
Encodes a protein that is likely to play a role in neural and glial cell adhesion in the developing Drosophila embryo.
Recessive alleles are embryonic lethals and show little or no evidence of Neuroglian expression; the overall structure of the CNS and PNS and in particular the peripheral nerve roots and CNS axon pathways develop in a relatively normal way in lethal embryos.
Two different forms of Nrg exist arising by tissue-specific, developmentally regulated alternative splicing. The two forms of Nrg have identical extracellular domains but differ in size of their cytoplasmic domains.
Origin and Etymology
Discoverer
Etymology
The gene is named "icebox" after the primary phenotype of mutants (the sexual receptivity of mutant females is lowered).
Identification
External Crossreferences and Linkouts ( 90 )
Sequence Crossreferences
NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
Other crossreferences
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
KEGG Genes - Molecular building blocks of life in the genomic space.
PDB - An information portal to biological macromolecular structures
Linkouts
DroID - A comprehensive database of gene and protein interactions.
Developmental Studies Hybridoma Bank - Monoclonal antibodies for use in research
Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
MIST (genetic) - An integrated Molecular Interaction Database
MIST (protein-protein) - An integrated Molecular Interaction Database
Synonyms and Secondary IDs (23)
Reported As
Symbol Synonym
Nrg
(Kanda et al., 2019, Yang et al., 2019, Wang et al., 2018, Zong et al., 2018, Fochler et al., 2017, Franz et al., 2017, Hartenstein et al., 2017, Vallejos Baier et al., 2017, Wilson and Bergstralh, 2017, Altenhein et al., 2016, Greiss et al., 2016, Malartre, 2016, Wang et al., 2016, Bergstralh et al., 2015, Bornstein et al., 2015, Byri et al., 2015, Garelli et al., 2015, Hildebrandt et al., 2015, Kanamori et al., 2015, Satoh et al., 2015, Wang et al., 2015, Ashwal-Fluss et al., 2014, Bätz et al., 2014, Bulat et al., 2014, DeSalvo et al., 2014, Hall et al., 2014, Hughes et al., 2014, Zarin et al., 2014, Zhang et al., 2014, Zhimulev et al., 2014, Burra et al., 2013, Diaper et al., 2013, Enneking et al., 2013, Gross et al., 2013, Osterfield et al., 2013, Ozkan et al., 2013, Ozkan et al., 2013, Sanchez-Garcia et al., 2013, Gistelinck et al., 2012, Ambegaokar and Jackson, 2011, Fauvarque and Williams, 2011, Goossens et al., 2011, Hatan et al., 2011, Hijazi et al., 2011, Mast et al., 2011, Pastor-Pareja and Xu, 2011, Seisenbacher et al., 2011, Sprecher et al., 2011, Pereanu et al., 2010, Popodi et al., 2010-, Tiklova et al., 2010, Tiklová et al., 2010, Godenschwege and Murphey, 2009, Laprise et al., 2009, Mao and Freeman, 2009, Massaro et al., 2009, Wang et al., 2009, Williams, 2009, Babcock et al., 2008, Chen and Hing, 2008, Derome et al., 2008, Kapelnikov et al., 2008, Kapelnikov et al., 2008, Laval et al., 2008, Sepp et al., 2008, Straub et al., 2008, Yi et al., 2008, Buszczak et al., 2007, Dietzl et al., 2007, Hortsch, 2007.9.19, Luque and Milan, 2007, Quinones-Coello, 2007, Szafranski and Goode, 2007, Whitington et al., 2007, Wu et al., 2007, Andrenacci et al., 2006, Furuse and Tsukita, 2006, Godenschwege, 2006, Godenschwege et al., 2006, Schneider et al., 2006, Schulte et al., 2006, Strigini et al., 2006, Kristiansen et al., 2005, Schwabe et al., 2005, Forni et al., 2004, Wei et al., 2004)
ibx
l(1)7Fa
l(1)G0488
Name Synonyms
Neuroglian
female sterile(1)M72
lethal (1) G0488
Secondary FlyBase IDs
  • FBgn0002968
  • FBgn0004669
  • FBgn0027311
  • FBgn0040142
  • FBgn0040165
  • FBgn0000874
  • FBgn0041750
Datasets (0)
Study focus (0)
Experimental Role
Project
Project Type
Title
References (392)