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Gene Dmel\Strn-Mlck

General Information
Symbol	Dmel\Strn-Mlck	Species	D. melanogaster
Name	Stretchin-Mlck	Annotation symbol	CG44162
Feature type	protein_coding_gene	FlyBase ID	FBgn0265045
Gene Model Status	Current	Stock availability	16 publicly available
Also Known As	MLCK, CG18255, A(225), Mlc-k, CT41348
Genomic Location
Chromosome (arm)	2R	Recombination map
Cytogenetic map	52D9-52D9	Sequence location	2R:11,834,438..11,877,003 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Stretchin-Mlck is referred to in FlyBase by the symbol Dmel\Strn-Mlck (CG44162, FBgn0265045). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: myosin light chain kinase activity; calmodulin-dependent protein kinase activity. Based on sequence similarity, it is predicted to be involved in the biological process: protein phosphorylation. 21 alleles are reported. No phenotypic data is available. It has 10 annotated transcripts and 10 annotated polypeptides. Protein features are: Fibronectin, type III; Immunoglobulin I-set; Immunoglobulin subtype; Immunoglobulin subtype 2; Immunoglobulin-like domain; Immunoglobulin-like fold; Myosin light chain kinase-related; Protein kinase, ATP binding site; Protein kinase, catalytic domain; Protein kinase-like domain; Serine/threonine- / dual specificity protein kinase, catalytic domain; Serine/threonine-protein kinase, active site. Gene sequence location is 2R:11834438..11877003.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 52D9-52D9   Limits computationally determined from genome sequence between P{lacW}l(2)k02205k02205&P{PZ}sli05248 and P{lacW}ATPCLk09217
Experimentally Determined Cytological Location
Cytogenetic map Notes References 52D-52D     (Champagne, 2000.4.14) 52D-52D     (Champagne, 2000.4.14) 52D-52D     (Champagne, 2000.4.14) 52D-52D     (Champagne, 2000.4.14) 52D-52D     (Champagne, 2000.4.14) 52D-52D     (Champagne, 2000.4.14) 52D-52D     (Champagne, 2000.4.14) 52D-52D     (Champagne, 2000.4.14) 52D2-52D7     (Kojima, 1996.12.3) 52D-52D   (determined by in situ hybridisation)   (Champagne et al., 1995) 52D4-52D15   (determined by in situ hybridisation)   (BDGP Project Members, 1994-1999)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Strn-Mlck for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.48 Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters. Low-frequency RNA-Seq exon junction(s) not annotated. Gene model includes transcripts encoding non-overlapping portions of the full CDS.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Strn-Mlck-RB FBtr0336644  NM_079030   3276   929 Strn-Mlck-RG FBtr0336643  NM_166128   3178   732 Strn-Mlck-RJ FBtr0336645  NM_001202020   2176   576 Strn-Mlck-RM FBtr0336646  NM_001202023   3287   913 Strn-Mlck-RN FBtr0336647  NM_001202024   2616   602 Strn-Mlck-RR FBtr0336648  NM_166130   6435   1918 Strn-Mlck-RS FBtr0336649  NM_001274089   25298   8216 Strn-Mlck-RT FBtr0336650  NM_001202026   24592   7905 Strn-Mlck-RU FBtr0336651  NM_001274090   25666   8255 Strn-Mlck-RV FBtr0336652  NM_166129   24960   7944
Additional Transcript Data & Comments
Reported size (kB)	18, 13, 5.2, 3.6 (northern blot) (Kojima et al., 1996)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Strn-Mlck-PB   FBpp0307628   102.0   929   8.54     NP_523754   AAF58089 Strn-Mlck-PG   FBpp0307627   80.5   732   7.45     NP_725509   AAM70938 Strn-Mlck-PJ   FBpp0307629   64.4   576   4.75     NP_001188949   ADV37195 Strn-Mlck-PM   FBpp0307630   100.1   913   8.54     NP_001188952   ADV37198 Strn-Mlck-PN   FBpp0307631   67.2   602   6.51     NP_001188953   ADV37199 Strn-Mlck-PR   FBpp0307632   215.1   1918   5.55     NP_725511   AAM70939 Strn-Mlck-PS   FBpp0307633   919.3   8216   4.79     NP_001261018   AGB93550 Strn-Mlck-PT   FBpp0307634   886.5   7905   4.74     NP_001188955   ADV37201 Strn-Mlck-PU   FBpp0307635   923.8   8255   4.77     NP_001261019   AGB93551 Strn-Mlck-PV   FBpp0307636   890.9   7944   4.72     NP_725510   AAF58087
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Protein kinase, catalytic domain (IPR000719) Serine/threonine- / dual specificity protein kinase, catalytic domain (IPR002290) Immunoglobulin subtype 2 (IPR003598) Immunoglobulin subtype (IPR003599) Fibronectin, type III (IPR003961) Immunoglobulin-like domain (IPR007110) Serine/threonine-protein kinase, active site (IPR008271) Protein kinase-like domain (IPR011009) Immunoglobulin-like fold (IPR013783) Protein kinase, ATP binding site (IPR017441) Myosin light chain kinase-related (IPR020675) Immunoglobulin I-set (IPR013098)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA264459   AA697372   AE013599 AAF58087   AE013599 AAF58089   AE013599 AAM70938   AE013599 AAM70939   AC004426   AC004516   AE013599 ADV37195   AE013599 ADV37198   AE013599 ADV37199   AE013599 ADV37201   AF254359 AAF90108   AF254360 AAF90109   AF254361 AAF90110   AF254362 AAF90111   AF254363 AAF90112   AF254364 AAF90113   AF254365 AAF90114   AF254366 AAF90115   AF254368 AAF90116   AF254369 AAF90117   AF254370 AAF90118   AF254371 AAF90119   AF254372 AAF90120   AF255667 AAG01794   AF255668 AAG01795   AF255669 AAG01796   AF255670 AAG01797   AF255671 AAG01798   AF255672 AAG01799   AF257306 AAF90124   AF257307 AAF90125   AF257308 AAF90126   AF257309 AAF90127   AF257310 AAF90128   AF257311 AAF90129   AF257312   AF257313 AAF90131   AE013599 AGB93550   AE013599 AGB93551   AI238593   AI388294   AI403054   AI403160   AI513718   AI513859   AI517150   AW940567   AW941074   AY061828 AAL27639   AY075340   AY113646 AAM29651   BF490632   BG633424   BG633438   BI215858   BI240062   BI486865   BI576243   BI579131   BI583213   BI592091   BI606990   BI607592   BI621713   BT029118   BT100296   CA804508   CA804828   CA805904   CA805992   CA806193   CA806213   CA806224   CA806274   CA806433   CA806452   CA806902   CA806918   CA807515   CO187179   CO270820   CO271994   CO303789   CO311418   CO336081   CO340862   CO343875   CZ468267   CZ479695   CZ479929   CZ479930   CZ480093   CZ480094   CZ483954   CZ484684   CZ484685   CZ486864   CZ486865   D89661 BAA19488   D89662 BAA19489   D89663 BAA20906   DN154272   EC051530   EC054490   EC054513   EC054518   EC055791   EC057531   EC072183   EC080261   EC088093   EC202357   EC213700   EC224645   EC255025   EC260370   EC261399   EL881692   EV577195   EV592863   EY198765   U51473 AAA96526
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	A1ZA69 A1ZA68 A1ZA70 A1ZA72 A1ZA74 Q9NBC1 Q9NBB0 Q9GTV0 A1ZA66 Q9NBC6 Q9GV81 O01653 Q9GV79 Q9NBB4 Q9NBB6 Q9NBA9 Q9GV80 A1ZA73 Q9NBB8 Q9NBB2 Q9NBB7 A1ZA67 Q9NBB1 Q9NBC2 Q9GTV1 Q9NBC4 Q24205 Q9NBB3 Q9GV82 O01651 Q9N630 O01652 Q9N6N9 Q9NBB9 Q8MYR8 Q9NBC3 Q95R30 Q9NBC0 Q9NBC5
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage   organism | ubiquitous   (Kojima et al., 1996)   (Kojima et al., 1996) embryonic stage -- adult stage     (Kojima et al., 1996) embryonic stage 15 -- 17   embryonic/larval muscle system   (Kojima et al., 1996) pupal stage | late     (Kojima et al., 1996) adult stage     (Kojima et al., 1996)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 5 of adulthood & male -- day 7 of adulthood & male   spermatozoon   (Wasbrough et al., 2010) day 7 of adulthood -- day 49 of adulthood   adult heart   (Cammarato et al., 2011)
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
microtubule associated complex inferred from direct assay (Hughes et al., 2008)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    1 central nervous system, larvae L3    1 central nervous system, pupae P8    2 head, virgin 1-day female    6 head, virgin 4-day female    5 head, virgin 20-day female    3 head, mated 1-day female    5 head, mated 4-day female    5 head, mated 20-day female    3 head, mated 1-day male    7 head, mated 4-day male    5 head, mated 20-day male    5 salivary gland, larvae L3 wandering    7 salivary gland, white prepupae    30 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    1 digestive system, 4-day adult    1 digestive system, 20-day adult    1 fat body, larvae L3 wandering    1 fat body, white prepupae    3 fat body, pupae P8    2 carcass, larvae L3 wandering    3 carcass, 1-day adult    75 carcass, 4-day adult    20 carcass, 20-day adult    13 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    1 central nervous system, larvae L3    1 central nervous system, pupae P8    2 head, virgin 1-day female    6 head, virgin 4-day female    5 head, virgin 20-day female    3 head, mated 1-day female    5 head, mated 4-day female    5 head, mated 20-day female    3 head, mated 1-day male    7 head, mated 4-day male    5 head, mated 20-day male    5 salivary gland, larvae L3 wandering    7 salivary gland, white prepupae  (30) digestive system, larvae L3 wandering    0 digestive system, 1-day adult    1 digestive system, 4-day adult    1 digestive system, 20-day adult    1 fat body, larvae L3 wandering    1 fat body, white prepupae    3 fat body, pupae P8    2 carcass, larvae L3 wandering    3 carcass, 1-day adult  (75) carcass, 4-day adult    20 carcass, 20-day adult    13 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    1 central nervous system, larvae L3    1 central nervous system, pupae P8    2 head, virgin 1-day female    6 head, virgin 4-day female    5 head, virgin 20-day female    3 head, mated 1-day female    5 head, mated 4-day female    5 head, mated 20-day female    3 head, mated 1-day male    7 head, mated 4-day male    5 head, mated 20-day male    5 salivary gland, larvae L3 wandering    7 salivary gland, white prepupae    30 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    1 digestive system, 4-day adult    1 digestive system, 20-day adult    1 fat body, larvae L3 wandering    1 fat body, white prepupae    3 fat body, pupae P8    2 carcass, larvae L3 wandering    3 carcass, 1-day adult    75 carcass, 4-day adult    20 carcass, 20-day adult    13 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    1 central nervous system, larvae L3    1 central nervous system, pupae P8    2 head, virgin 1-day female    6 head, virgin 4-day female    5 head, virgin 20-day female    3 head, mated 1-day female    5 head, mated 4-day female    5 head, mated 20-day female    3 head, mated 1-day male    7 head, mated 4-day male    5 head, mated 20-day male    5 salivary gland, larvae L3 wandering    7 salivary gland, white prepupae    30 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    1 digestive system, 4-day adult    1 digestive system, 20-day adult    1 fat body, larvae L3 wandering    1 fat body, white prepupae    3 fat body, pupae P8    2 carcass, larvae L3 wandering    3 carcass, 1-day adult    75 carcass, 4-day adult    20 carcass, 20-day adult    13 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    3 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    1 central nervous system, larvae L3    1 central nervous system, pupae P8    2 head, virgin 1-day female    6 head, virgin 4-day female    5 head, virgin 20-day female    3 head, mated 1-day female    5 head, mated 4-day female    5 head, mated 20-day female    3 head, mated 1-day male    7 head, mated 4-day male    5 head, mated 20-day male    5 salivary gland, larvae L3 wandering    7 salivary gland, white prepupae    30 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    1 digestive system, 4-day adult    1 digestive system, 20-day adult    1 fat body, larvae L3 wandering    1 fat body, white prepupae    3 fat body, pupae P8    2 carcass, larvae L3 wandering    3 carcass, 1-day adult    75 carcass, 4-day adult    20 carcass, 20-day adult    13 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    1 central nervous system, larvae L3    1 central nervous system, pupae P8    2 head, virgin 1-day female    6 head, virgin 4-day female    5 head, virgin 20-day female    3 head, mated 1-day female    5 head, mated 4-day female    5 head, mated 20-day female    3 head, mated 1-day male    7 head, mated 4-day male    5 head, mated 20-day male    5 salivary gland, larvae L3 wandering    7 salivary gland, white prepupae  30 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    1 digestive system, 4-day adult    1 digestive system, 20-day adult    1 fat body, larvae L3 wandering    1 fat body, white prepupae    3 fat body, pupae P8    2 carcass, larvae L3 wandering    3 carcass, 1-day adult  (75) carcass, 4-day adult    20 carcass, 20-day adult    13 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    1 central nervous system, larvae L3    1 central nervous system, pupae P8    2 head, virgin 1-day female    6 head, virgin 4-day female    5 head, virgin 20-day female    3 head, mated 1-day female    5 head, mated 4-day female    5 head, mated 20-day female    3 head, mated 1-day male    7 head, mated 4-day male    5 head, mated 20-day male    5 salivary gland, larvae L3 wandering    7 salivary gland, white prepupae    30 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    1 digestive system, 4-day adult    1 digestive system, 20-day adult    1 fat body, larvae L3 wandering    1 fat body, white prepupae    3 fat body, pupae P8    2 carcass, larvae L3 wandering    3 carcass, 1-day adult    75 carcass, 4-day adult    20 carcass, 20-day adult    13 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    1 central nervous system, larvae L3    1 central nervous system, pupae P8    2 head, virgin 1-day female    6 head, virgin 4-day female    5 head, virgin 20-day female    3 head, mated 1-day female    5 head, mated 4-day female    5 head, mated 20-day female    3 head, mated 1-day male    7 head, mated 4-day male    5 head, mated 20-day male    5 salivary gland, larvae L3 wandering    7 salivary gland, white prepupae    30 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    1 digestive system, 4-day adult    1 digestive system, 20-day adult    1 fat body, larvae L3 wandering    1 fat body, white prepupae    3 fat body, pupae P8    2 carcass, larvae L3 wandering    3 carcass, 1-day adult    75 carcass, 4-day adult    20 carcass, 20-day adult    13 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    1 embryo 06-08hr    1 embryo 08-10hr    1 embryo 10-12hr    2 embryo 12-14hr    5 embryo 14-16hr    13 embryo 16-18hr    10 embryo 18-20hr    9 embryo 20-22hr    6 embryo 22-24hr    7 larva L1    7 larva L2    5 larva L3 12hr old    6 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    5 larva L3 puffstage 7-9    6 white prepupae new    5 white prepupae 12hr    20 white prepupae 24hr    3 pupae 2d postWPP    8 pupae 3d postWPP    92 pupae 4d postWPP    173 adult male 01day    79 adult male 05day    27 adult male 30day    16 adult female 01day    73 adult female 05day    5 adult female 30day    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    1 embryo 06-08hr    1 embryo 08-10hr    1 embryo 10-12hr    2 embryo 12-14hr    5 embryo 14-16hr    13 embryo 16-18hr    10 embryo 18-20hr    9 embryo 20-22hr    6 embryo 22-24hr    7 larva L1    7 larva L2    5 larva L3 12hr old    6 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    5 larva L3 puffstage 7-9    6 white prepupae new    5 white prepupae 12hr    20 white prepupae 24hr    3 pupae 2d postWPP    8 pupae 3d postWPP  (92) pupae 4d postWPP  (173) adult male 01day  (79) adult male 05day  (27) adult male 30day    16 adult female 01day  (73) adult female 05day    5 adult female 30day    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    1 embryo 06-08hr    1 embryo 08-10hr    1 embryo 10-12hr    2 embryo 12-14hr    5 embryo 14-16hr    13 embryo 16-18hr    10 embryo 18-20hr    9 embryo 20-22hr    6 embryo 22-24hr    7 larva L1    7 larva L2    5 larva L3 12hr old    6 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    5 larva L3 puffstage 7-9    6 white prepupae new    5 white prepupae 12hr    20 white prepupae 24hr    3 pupae 2d postWPP    8 pupae 3d postWPP    92 pupae 4d postWPP  (173) adult male 01day    79 adult male 05day    27 adult male 30day    16 adult female 01day    73 adult female 05day    5 adult female 30day    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    1 embryo 06-08hr    1 embryo 08-10hr    1 embryo 10-12hr    2 embryo 12-14hr    5 embryo 14-16hr    13 embryo 16-18hr    10 embryo 18-20hr    9 embryo 20-22hr    6 embryo 22-24hr    7 larva L1    7 larva L2    5 larva L3 12hr old    6 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    5 larva L3 puffstage 7-9    6 white prepupae new    5 white prepupae 12hr    20 white prepupae 24hr    3 pupae 2d postWPP    8 pupae 3d postWPP    92 pupae 4d postWPP    173 adult male 01day    79 adult male 05day    27 adult male 30day    16 adult female 01day    73 adult female 05day    5 adult female 30day    2 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    1 embryo 06-08hr    1 embryo 08-10hr    1 embryo 10-12hr    2 embryo 12-14hr    5 embryo 14-16hr    13 embryo 16-18hr    10 embryo 18-20hr    9 embryo 20-22hr    6 embryo 22-24hr    7 larva L1    7 larva L2    5 larva L3 12hr old    6 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    5 larva L3 puffstage 7-9    6 white prepupae new    5 white prepupae 12hr    20 white prepupae 24hr    3 pupae 2d postWPP    8 pupae 3d postWPP    92 pupae 4d postWPP    173 adult male 01day    79 adult male 05day    27 adult male 30day    16 adult female 01day    73 adult female 05day    5 adult female 30day    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    1 embryo 06-08hr    1 embryo 08-10hr    1 embryo 10-12hr    2 embryo 12-14hr    5 embryo 14-16hr    13 embryo 16-18hr    10 embryo 18-20hr    9 embryo 20-22hr    6 embryo 22-24hr    7 larva L1    7 larva L2    5 larva L3 12hr old    6 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    5 larva L3 puffstage 7-9    6 white prepupae new    5 white prepupae 12hr    20 white prepupae 24hr    3 pupae 2d postWPP    8 pupae 3d postWPP  (92) pupae 4d postWPP  (173) adult male 01day  (79) adult male 05day  27 adult male 30day    16 adult female 01day  (73) adult female 05day    5 adult female 30day    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    1 embryo 06-08hr    1 embryo 08-10hr    1 embryo 10-12hr    2 embryo 12-14hr    5 embryo 14-16hr    13 embryo 16-18hr    10 embryo 18-20hr    9 embryo 20-22hr    6 embryo 22-24hr    7 larva L1    7 larva L2    5 larva L3 12hr old    6 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    5 larva L3 puffstage 7-9    6 white prepupae new    5 white prepupae 12hr    20 white prepupae 24hr    3 pupae 2d postWPP    8 pupae 3d postWPP    92 pupae 4d postWPP  (173) adult male 01day    79 adult male 05day    27 adult male 30day    16 adult female 01day    73 adult female 05day    5 adult female 30day    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    1 embryo 06-08hr    1 embryo 08-10hr    1 embryo 10-12hr    2 embryo 12-14hr    5 embryo 14-16hr    13 embryo 16-18hr    10 embryo 18-20hr    9 embryo 20-22hr    6 embryo 22-24hr    7 larva L1    7 larva L2    5 larva L3 12hr old    6 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    5 larva L3 puffstage 7-9    6 white prepupae new    5 white prepupae 12hr    20 white prepupae 24hr    3 pupae 2d postWPP    8 pupae 3d postWPP    92 pupae 4d postWPP    173 adult male 01day    79 adult male 05day    27 adult male 30day    16 adult female 01day    73 adult female 05day    5 adult female 30day    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    1 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    4 embryonic Kc167    0 embryonic S1    3 embryonic S3    2 leg disc CME L1    0 wing disc CME-W2    3 wing disc ML-DmD8    1 wing disc ML-DmD9    1 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    1 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    1 ovary fGS/OSS    1 ovary OSC    2 ovary OSS    1 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    1 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    4 embryonic Kc167    0 embryonic S1    3 embryonic S3    2 leg disc CME L1    0 wing disc CME-W2    3 wing disc ML-DmD8    1 wing disc ML-DmD9    1 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    1 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    1 ovary fGS/OSS    1 ovary OSC    2 ovary OSS    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    1 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    4 embryonic Kc167    0 embryonic S1    3 embryonic S3    2 leg disc CME L1    0 wing disc CME-W2    3 wing disc ML-DmD8    1 wing disc ML-DmD9    1 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    1 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    1 ovary fGS/OSS    1 ovary OSC    2 ovary OSS    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    1 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    4 embryonic Kc167    0 embryonic S1    3 embryonic S3    2 leg disc CME L1    0 wing disc CME-W2    3 wing disc ML-DmD8    1 wing disc ML-DmD9    1 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    1 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    1 ovary fGS/OSS    1 ovary OSC    2 ovary OSS    1 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    1 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    4 embryonic Kc167    0 embryonic S1    3 embryonic S3    2 leg disc CME L1    0 wing disc CME-W2    3 wing disc ML-DmD8    1 wing disc ML-DmD9    1 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    1 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    1 ovary fGS/OSS    1 ovary OSC    2 ovary OSS    1 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    1 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    4 embryonic Kc167    0 embryonic S1    3 embryonic S3    2 leg disc CME L1    0 wing disc CME-W2    3 wing disc ML-DmD8    1 wing disc ML-DmD9    1 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    1 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    1 ovary fGS/OSS    1 ovary OSC    2 ovary OSS    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    1 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    4 embryonic Kc167    0 embryonic S1    3 embryonic S3    2 leg disc CME L1    0 wing disc CME-W2    3 wing disc ML-DmD8    1 wing disc ML-DmD9    1 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    1 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    1 ovary fGS/OSS    1 ovary OSC    2 ovary OSS    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    1 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    4 embryonic Kc167    0 embryonic S1    3 embryonic S3    2 leg disc CME L1    0 wing disc CME-W2    3 wing disc ML-DmD8    1 wing disc ML-DmD9    1 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    1 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    1 ovary fGS/OSS    1 ovary OSC    2 ovary OSS    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    6 cold shock, 4-day adult    4 heat shock, 4-day adult    5 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    4 Cadmium 100 mM 48 hrs, 4-day adult    6 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    7 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3    7 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    3 Caffeine 25 mg/ml 48 hrs, 4-day adult    3 Paraquat 5 mM 48 hrs, 4-day adult    7 Paraquat 10 mM 48 hrs, 4-day adult    12 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    6 cold shock, 4-day adult    4 heat shock, 4-day adult    5 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    4 Cadmium 100 mM 48 hrs, 4-day adult    6 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    7 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3    7 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    3 Caffeine 25 mg/ml 48 hrs, 4-day adult    3 Paraquat 5 mM 48 hrs, 4-day adult    7 Paraquat 10 mM 48 hrs, 4-day adult    12 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    6 cold shock, 4-day adult    4 heat shock, 4-day adult    5 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    4 Cadmium 100 mM 48 hrs, 4-day adult    6 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    7 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3    7 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    3 Caffeine 25 mg/ml 48 hrs, 4-day adult    3 Paraquat 5 mM 48 hrs, 4-day adult    7 Paraquat 10 mM 48 hrs, 4-day adult    12 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    6 cold shock, 4-day adult    4 heat shock, 4-day adult    5 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    4 Cadmium 100 mM 48 hrs, 4-day adult    6 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    7 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3    7 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    3 Caffeine 25 mg/ml 48 hrs, 4-day adult    3 Paraquat 5 mM 48 hrs, 4-day adult    7 Paraquat 10 mM 48 hrs, 4-day adult    12 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    6 cold shock, 4-day adult    4 heat shock, 4-day adult    5 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    4 Cadmium 100 mM 48 hrs, 4-day adult    6 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    7 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3    7 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    3 Caffeine 25 mg/ml 48 hrs, 4-day adult    3 Paraquat 5 mM 48 hrs, 4-day adult    7 Paraquat 10 mM 48 hrs, 4-day adult    12 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    6 cold shock, 4-day adult    4 heat shock, 4-day adult    5 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    4 Cadmium 100 mM 48 hrs, 4-day adult    6 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    7 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3    7 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    3 Caffeine 25 mg/ml 48 hrs, 4-day adult    3 Paraquat 5 mM 48 hrs, 4-day adult    7 Paraquat 10 mM 48 hrs, 4-day adult    12 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    6 cold shock, 4-day adult    4 heat shock, 4-day adult    5 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    4 Cadmium 100 mM 48 hrs, 4-day adult    6 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    7 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3    7 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    3 Caffeine 25 mg/ml 48 hrs, 4-day adult    3 Paraquat 5 mM 48 hrs, 4-day adult    7 Paraquat 10 mM 48 hrs, 4-day adult    12 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    6 cold shock, 4-day adult    4 heat shock, 4-day adult    5 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    4 Cadmium 100 mM 48 hrs, 4-day adult    6 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    7 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3    7 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    3 Caffeine 25 mg/ml 48 hrs, 4-day adult    3 Paraquat 5 mM 48 hrs, 4-day adult    7 Paraquat 10 mM 48 hrs, 4-day adult    12 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_24 mE1_20_mRNA_expression_cluster_08
External Data & Images
Linkouts	BDGP expression data • GH27795
Alleles & Phenotypes
Summary of Allele Phenotypes
Phenotype manifest in Allele
Classical Alleles ( 13 )
For All Classical Alleles Show
Allele of Strn-Mlck Class Mutagen Stocks Known lesion Strn-Mlckc02860 piggyBac transposase 2 -- Strn-MlckC234 1 -- Strn-Mlcke01878 piggyBac transposase 1 -- Strn-Mlcke02266 piggyBac transposase 1 -- Strn-Mlckf01482 piggyBac transposase 1 -- Strn-Mlckf02175 piggyBac transposase 1 -- Strn-Mlckf04333 piggyBac transposase 1 -- Strn-MlckMI00790 1 -- Strn-MlckMI00830 1 -- Strn-MlckMI02893 1 -- Strn-MlckMI06460 1 -- Strn-Mlcke02100 piggyBac transposase 0 -- Strn-Mlckf05615 0 --
Alleles Carried on Transgenic Constructs ( 8 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Strn-Mlck Class Mutagen Stocks Known lesion Strn-MlckHMS01665 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Strn-MlckHMS02663 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Strn-MlckJF02170 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Strn-MlckJF02278 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Strn-MlckdsRNA.cHa in vitro construct - RNAi 0 -- Strn-MlckGD8623 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes Strn-MlckKK113175 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes Strn-MlckNIG.18255R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2R)Exel7138 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD8623} NA P{NIG.18255R} NA P{TRiP.HMS01665} NA P{TRiP.HMS02663} NA P{TRiP.JF02170} NA P{TRiP.JF02278} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions Mi{MIC}Strn-MlckMI00790 NA Mi{MIC}Strn-MlckMI00830 NA Mi{MIC}Strn-MlckMI02893 NA Mi{MIC}Strn-MlckMI06460 NA PBac{3HPy+}Strn-MlckC234 NA PBac{PB}Strn-Mlckc02860 NA PBac{RB}Strn-Mlcke01878 NA PBac{RB}Strn-Mlcke02100 NA PBac{RB}Strn-Mlcke02266 NA PBac{WH}Strn-Mlckf01482 NA PBac{WH}Strn-Mlckf02175 NA PBac{WH}Strn-Mlckf04333 NA PBac{WH}Strn-Mlckf05615 NA
Gene Ontology: Function, Process & Cellular Component ( 7 unique terms )
Terms Based on Experimental Evidence ( 3 terms )
Molecular Function
CV term Evidence References
calmodulin-dependent protein kinase activity inferred from direct assay (Kojima et al., 1996) myosin light chain kinase activity inferred from direct assay AND inferred from sequence or structural similarity (Kojima et al., 1996)
Biological Process ( 0 terms)
Cellular Component
CV term Evidence References
microtubule associated complex inferred from direct assay (Hughes et al., 2008)
Terms Based on Predictions or Assertions ( 5 terms )
Molecular Function
CV term Evidence References
ATP binding inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR002290, InterPro:IPR017441 (FlyBase Curators et al., 2004-) myosin light chain kinase activity inferred from sequence or structural similarity with bt (Champagne et al., 2000) protein serine/threonine kinase activity non-traceable author statement (Morrison et al., 2000) structural constituent of cytoskeleton inferred from sequence or structural similarity with bt (Champagne et al., 2000) inferred from sequence or structural similarity with sls (Champagne et al., 2000)
Biological Process
CV term Evidence References
protein phosphorylation inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR002290, InterPro:IPR008271 (FlyBase Curators et al., 2004-) inferred from sequence or structural similarity (Kojima et al., 1996) non-traceable author statement (Morrison et al., 2000)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
Strn-Mlck - Act88F experimental knowledge based (Guruharsha et al., 2011) Strn-Mlck - CG14879 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Strn-Mlck - CG34172 experimental knowledge based (Guruharsha et al., 2011) Strn-Mlck - CG6330 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Strn-Mlck - Gpdh experimental knowledge based (Guruharsha et al., 2011) Strn-Mlck - Gpo-1 experimental knowledge based (Guruharsha et al., 2011) Strn-Mlck - GstS1 experimental knowledge based (Guruharsha et al., 2011) Strn-Mlck - fln experimental knowledge based (Guruharsha et al., 2011) Strn-Mlck - regucalcin anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Strn-Mlck allele Gene References
External Data
Linkouts
Orthologs
OrthoDB Orthologs (247) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6QVCX8, EOG62NJM6, EOG68GWNK, EOG6WM5FR Dipteran inclusive ortholog search EOG6W0XN0 Insect inclusive ortholog search EOG60CGBR, EOG602VMZ Arthropod inclusive ortholog search EOG605QFW Metazoa inclusive ortholog search EOG6677CK
Orthologs in Drosophila Species (EOG6QVCX8, EOG62NJM6, EOG68GWNK, EOG6WM5FR)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Ccp84Ab     Drosophila melanogaster fruit fly  Dmel\CG13059     Drosophila melanogaster fruit fly  Dmel\CG42784     Drosophila melanogaster fruit fly  Dmel\CG5181     Drosophila melanogaster fruit fly  Dmel\sba     Drosophila melanogaster fruit fly  Dmel\Pif2     Drosophila melanogaster fruit fly  Dmel\Strn-Mlck     Drosophila melanogaster fruit fly  Dmel\byn     Drosophila melanogaster fruit fly  Dmel\CG43332     Drosophila melanogaster fruit fly  Dmel\CHES-1-like     Drosophila melanogaster fruit fly  Dmel\srp     Drosophila simulans   Dsim\GD25580 Y   Drosophila simulans   Dsim\GD25582   Y Drosophila sechellia   Dsec\GM20104 Y   Drosophila sechellia   Dsec\GM20106 Y Y Drosophila erecta   Dere\GG22314 Y   Drosophila erecta   Dere\GG22317   Y Drosophila yakuba   Dyak\GE14112 Y   Drosophila yakuba   Dyak\GE14114   Y Drosophila ananassae   Dana\GF13332 Y   Drosophila ananassae   Dana\GF13334 Y Y Drosophila pseudoobscura pseudoobscura   Dpse\GA13898 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA30265 Y Y Drosophila persimilis   Dper\GL20658   Y Drosophila persimilis   Dper\GL20657   Y Drosophila willistoni   Dwil\GK22101 Y   Drosophila willistoni   Dwil\GK22103 Y Y Drosophila virilis   Dvir\GJ20093 Y   Drosophila virilis   Dvir\GJ20095 Y Y Drosophila virilis   Dvir\GJ16020   Y Drosophila virilis   Dvir\GJ18382   Y Drosophila mojavensis   Dmoj\GI20421 Y Y Drosophila grimshawi   Dgri\GH19834 Y Y
Orthologs in non-Drosophila Dipterans (EOG6W0XN0)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL008057 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ012863 Y
Orthologs in non-Dipteran Insects (EOG60CGBR, EOG602VMZ)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB47946 Y Apis mellifera Western honey bee  Amel\GB47948 Y Apis mellifera Western honey bee  Amel\GB47947 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG016102 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG016115 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG016114 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG016113 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG015617 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH27154 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH15218 Y Atta cephalotes Leafcutter ant  Acep\ACEP15048 Y Atta cephalotes Leafcutter ant  Acep\ACEP26046 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO14725 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL25964 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL24167 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL28060 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL20757 Y Linepithema humile Argentine ant  Lhum\LH14217 Y Linepithema humile Argentine ant  Lhum\LH25501 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB26557 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB15729 Y Solenopsis invicta Red fire ant  Sinv\SINV12027 Y Solenopsis invicta Red fire ant  Sinv\SINV12023 Y Solenopsis invicta Red fire ant  Sinv\SINV12020 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI069103 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI007076 Y Bombyx mori Silkmoth  Bmor\BGIBMGA002035 Y Bombyx mori Silkmoth  Bmor\BGIBMGA002036 Y Pediculus humanus Human body louse  Phum\PHUM541150 Y Tribolium castaneum Red flour beetle  Tcas\TC002962 Y
Orthologs in non-Insect Arthropods (EOG605QFW)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\Thtpa Y Daphnia pulex Water flea  Dpux\JGI_V11_53743 Y Daphnia pulex Water flea  Dpux\JGI_V11_305289 Y
Orthologs in non-Arthropod Metazoa (EOG6677CK)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\ssq-4 Y Caenorhabditis elegans Nematode  Cele\him-4 Y Caenorhabditis elegans Nematode  Cele\Y48C3A.12 Y Caenorhabditis elegans Nematode  Cele\ZC178.2 Y Caenorhabditis elegans Nematode  Cele\F11E6.3 Y Caenorhabditis elegans Nematode  Cele\ZK617.1 Y Caenorhabditis elegans Nematode  Cele\F41E6.11 Y Caenorhabditis elegans Nematode  Cele\ttn-1 Y Caenorhabditis elegans Nematode  Cele\npp-4 Y Caenorhabditis elegans Nematode  Cele\cut-2 Y Caenorhabditis elegans Nematode  Cele\ssq-3 Y Caenorhabditis elegans Nematode  Cele\ssq-2 Y Caenorhabditis elegans Nematode  Cele\W07G1.5 Y Caenorhabditis elegans Nematode  Cele\col-135 Y Caenorhabditis elegans Nematode  Cele\ssq-1 Y Caenorhabditis elegans Nematode  Cele\dur-1 Y Caenorhabditis elegans Nematode  Cele\C10G11.7 Y Caenorhabditis elegans Nematode  Cele\B0205.10 Y Caenorhabditis elegans Nematode  Cele\C02B10.5 Y Caenorhabditis elegans Nematode  Cele\ZC373.4 Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_023876gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_017487gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_000057gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_000442gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_008085gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_009818gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_010006gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_015813gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_013917gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_011693gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_008653gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_003460gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_023875gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_005613gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_001282gn Y Danio rerio Zebrafish  Drer\ENSDARG00000044673 Y Danio rerio Zebrafish  Drer\im:7148400 Y Danio rerio Zebrafish  Drer\ENSDARG00000034801 Y Danio rerio Zebrafish  Drer\ttnb Y Danio rerio Zebrafish  Drer\mylk4 Y Danio rerio Zebrafish  Drer\hmcn2 Y Danio rerio Zebrafish  Drer\mylk2 Y Danio rerio Zebrafish  Drer\hmcn1 Y Danio rerio Zebrafish  Drer\dscama Y Danio rerio Zebrafish  Drer\ENSDARG00000091260 Y Danio rerio Zebrafish  Drer\BX548021.2 Y Danio rerio Zebrafish  Drer\dscamb Y Danio rerio Zebrafish  Drer\ENSDARG00000004753 Y Danio rerio Zebrafish  Drer\dscaml1 Y Danio rerio Zebrafish  Drer\ttna Y Danio rerio Zebrafish  Drer\mylk3 Y Danio rerio Zebrafish  Drer\ENSDARG00000029048 Y Danio rerio Zebrafish  Drer\ENSDARG00000039311 Y Xenopus tropicalis Western clawed frog  Xtro\tn3 Y Xenopus tropicalis Western clawed frog  Xtro\ENSXETG00000015021 Y Xenopus tropicalis Western clawed frog  Xtro\mylk3 Y Xenopus tropicalis Western clawed frog  Xtro\mylk4 Y Xenopus tropicalis Western clawed frog  Xtro\ENSXETG00000033779 Y Xenopus tropicalis Western clawed frog  Xtro\dscaml1 Y Xenopus tropicalis Western clawed frog  Xtro\mylk Y Xenopus tropicalis Western clawed frog  Xtro\dscam Y Xenopus tropicalis Western clawed frog  Xtro\hmcn1 Y Xenopus tropicalis Western clawed frog  Xtro\hmcn2 Y Gallus gallus Domestic chicken  Ggal\ENSGALG00000024448 Y Gallus gallus Domestic chicken  Ggal\LOC427896 Y Gallus gallus Domestic chicken  Ggal\NOVA1 Y Gallus gallus Domestic chicken  Ggal\HMCN1 Y Gallus gallus Domestic chicken  Ggal\ENSGALG00000011775 Y Gallus gallus Domestic chicken  Ggal\DSCAM Y Gallus gallus Domestic chicken  Ggal\ENSGALG00000024060 Y Gallus gallus Domestic chicken  Ggal\ENSGALG00000011759 Y Gallus gallus Domestic chicken  Ggal\770789 Y Gallus gallus Domestic chicken  Ggal\ENSGALG00000007204 Y Gallus gallus Domestic chicken  Ggal\MYLK2 Y Gallus gallus Domestic chicken  Ggal\MYLK3 Y Gallus gallus Domestic chicken  Ggal\MYLK Y Gallus gallus Domestic chicken  Ggal\DSCAML1 Y Gallus gallus Domestic chicken  Ggal\MYLK4 Y Gallus gallus Domestic chicken  Ggal\LOC428278 Y Gallus gallus Domestic chicken  Ggal\ENSGALG00000011771 Y Mus musculus House mouse  Mmus\Lce1j Y Mus musculus House mouse  Mmus\Krtap6-1 Y Mus musculus House mouse  Mmus\Krtap6-1 Y Mus musculus House mouse  Mmus\Krtap16-7 Y Mus musculus House mouse  Mmus\Syn2 Y Mus musculus House mouse  Mmus\Lce1l Y Mus musculus House mouse  Mmus\Gm14185 Y Mus musculus House mouse  Mmus\Gm14193 Y Mus musculus House mouse  Mmus\Gm14193 Y Mus musculus House mouse  Mmus\Gm10217 Y Mus musculus House mouse  Mmus\Dscaml1 Y Mus musculus House mouse  Mmus\Gm10229 Y Mus musculus House mouse  Mmus\Dscam Y Mus musculus House mouse  Mmus\Hist1h1d Y Mus musculus House mouse  Mmus\Krtap16-8 Y Mus musculus House mouse  Mmus\Mylk Y Mus musculus House mouse  Mmus\Lce1c Y Mus musculus House mouse  Mmus\ENSMUSG00000051747 Y Mus musculus House mouse  Mmus\Barhl2 Y Mus musculus House mouse  Mmus\Gm14177 Y Mus musculus House mouse  Mmus\Hmcn1 Y Mus musculus House mouse  Mmus\Marcks Y Mus musculus House mouse  Mmus\Gm14190 Y Mus musculus House mouse  Mmus\Hist1h1c Y Mus musculus House mouse  Mmus\Foxd3 Y Mus musculus House mouse  Mmus\Gm10563 Y Mus musculus House mouse  Mmus\Gm17606 Y Mus musculus House mouse  Mmus\Gm14191 Y Mus musculus House mouse  Mmus\Tmem158 Y Mus musculus House mouse  Mmus\Gm14181 Y Mus musculus House mouse  Mmus\Krtap16.10L Y Mus musculus House mouse  Mmus\Mylk4 Y Mus musculus House mouse  Mmus\Gm6871 Y Mus musculus House mouse  Mmus\Gm11595 Y Mus musculus House mouse  Mmus\Mylk2 Y Mus musculus House mouse  Mmus\Krtap6-1 Y Mus musculus House mouse  Mmus\Lce1e Y Mus musculus House mouse  Mmus\Gm11564 Y Mus musculus House mouse  Mmus\Gm10974 Y Mus musculus House mouse  Mmus\Krtap4-9 Y Mus musculus House mouse  Mmus\Hmcn2 Y Mus musculus House mouse  Mmus\Gm14196 Y Mus musculus House mouse  Mmus\Phgr1 Y Mus musculus House mouse  Mmus\Mylk3 Y Mus musculus House mouse  Mmus\Gm14192 Y Mus musculus House mouse  Mmus\Lce1f Y Mus musculus House mouse  Mmus\Gm14193 Y Mus musculus House mouse  Mmus\Krtap4-8 Y Mus musculus House mouse  Mmus\Gm11034 Y Mus musculus House mouse  Mmus\Gm14178 Y Mus musculus House mouse  Mmus\Gm8223 Y Mus musculus House mouse  Mmus\Sox3 Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000030872 Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000043220 Y Rattus norvegicus Norway rat  Rnor\Dscaml1 Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000039623 Y Rattus norvegicus Norway rat  Rnor\Hmcn1 Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000022637 Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000030293 Y Rattus norvegicus Norway rat  Rnor\Mylk3 Y Rattus norvegicus Norway rat  Rnor\Mylk2 Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000038781 Y Rattus norvegicus Norway rat  Rnor\RGD1565323 Y Rattus norvegicus Norway rat  Rnor\Dscam Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000030744 Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000033548 Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000038410 Y Rattus norvegicus Norway rat  Rnor\Mylk Y Rattus norvegicus Norway rat  Rnor\LOC684744 Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000008820 Y Homo sapiens Human  Hsap\KRTAP6-1 Y Homo sapiens Human  Hsap\ENSG00000249992 Y Homo sapiens Human  Hsap\ENSG00000257153 Y Homo sapiens Human  Hsap\ELN Y Homo sapiens Human  Hsap\PHGR1 Y Homo sapiens Human  Hsap\KRTAP5-5 Y Homo sapiens Human  Hsap\DSCAM Y Homo sapiens Human  Hsap\HMCN1 Y Homo sapiens Human  Hsap\MYLK3 Y Homo sapiens Human  Hsap\ENSG00000065534 Y Homo sapiens Human  Hsap\KRTAP5-8 Y Homo sapiens Human  Hsap\ENSG00000262483 Y Homo sapiens Human  Hsap\NKX1-1 Y Homo sapiens Human  Hsap\ENSG00000262498 Y Homo sapiens Human  Hsap\ENSG00000258264 Y Homo sapiens Human  Hsap\HMCN2 Y Homo sapiens Human  Hsap\KRTAP5-1 Y Homo sapiens Human  Hsap\ENSG00000257917 Y Homo sapiens Human  Hsap\ENSG00000263306 Y Homo sapiens Human  Hsap\CT47B1 Y Homo sapiens Human  Hsap\DSCAML1 Y Homo sapiens Human  Hsap\FOXD3 Y Homo sapiens Human  Hsap\KRTAP5-4 Y Homo sapiens Human  Hsap\BAG3 Y Homo sapiens Human  Hsap\ENSG00000262626 Y Homo sapiens Human  Hsap\MARCKS Y Homo sapiens Human  Hsap\MYLK2 Y Homo sapiens Human  Hsap\TTN Y Homo sapiens Human  Hsap\MYLK4 Y
Human Orthologs (29)
Gene OMIM HGNC Hsap\KRTAP6-1     Hsap\ENSG00000249992     Hsap\ENSG00000257153     Hsap\ELN     Hsap\PHGR1     Hsap\KRTAP5-5     Hsap\DSCAM     Hsap\HMCN1     Hsap\MYLK3     Hsap\ENSG00000065534     Hsap\KRTAP5-8     Hsap\ENSG00000262483     Hsap\NKX1-1     Hsap\ENSG00000262498     Hsap\ENSG00000258264     Hsap\HMCN2     Hsap\KRTAP5-1     Hsap\ENSG00000257917     Hsap\ENSG00000263306     Hsap\CT47B1     Hsap\DSCAML1     Hsap\FOXD3     Hsap\KRTAP5-4     Hsap\BAG3     Hsap\ENSG00000262626     Hsap\MARCKS     Hsap\MYLK2     Hsap\TTN     Hsap\MYLK4
AAA Orthologs (19) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD25580 Drosophila simulans Dsim\GD25583 Drosophila sechellia Dsec\GM20104 Drosophila sechellia Dsec\GM20106 Drosophila erecta Dere\GG22314 Drosophila erecta Dere\GG22319 Drosophila yakuba Dyak\GE14112 Drosophila yakuba Dyak\GE14115 Drosophila ananassae Dana\GF13332 Drosophila ananassae Dana\GF13334 Drosophila pseudoobscura pseudoobscura Dpse\GA13898 Drosophila pseudoobscura pseudoobscura Dpse\GA30265 Drosophila persimilis Dper\GL20659 Drosophila willistoni Dwil\GK22101 Drosophila willistoni Dwil\GK22103 Drosophila virilis Dvir\GJ20093 Drosophila virilis Dvir\GJ20095 Drosophila mojavensis Dmoj\GI20421 Drosophila grimshawi Dgri\GH19834
Stocks & Reagents
Stocks Listed in FlyBase ( 16 )
Bloomington	26736 y1 v1; P{TRiP.JF02278}attP2 31891 y1 v1; P{TRiP.JF02170}attP2 11089 w1118; PBac{PB}Strn-Mlckc02860/CyO 33089 y1 w*; Mi{MIC}Strn-MlckMI00830 37038 y1 w*; Mi{MIC}Strn-MlckMI02893 37523 y1 sc* v1; P{TRiP.HMS01665}attP40
Harvard	- PBac{PB}Strn-Mlckc02860 - PBac{RB}Strn-Mlcke01878 - PBac{RB}Strn-Mlcke02266 - PBac{WH}Strn-Mlckf01482 - PBac{WH}Strn-Mlckf02175 - PBac{WH}Strn-Mlckf04333
	More stocks available...
Genomic Clones ( 2 )
	BACR04O19 BACR07M03 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 61 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GH14667 GH27795 RH61010 RH74685
Other clones	IP15344
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT27167 GH19138 GH22415 GH22543 GH26774 HL02342 LD08971 RE22613 RE36709 RE70343 RE73115 RH09713 RH21754 RH32768 RH53111 RH73963
Other clones	15185 78856 103110 106914 214307.72 214317.75 556971 CK01.23D.H11 CK01.31A.E3 Dmel_dig_019231_0632_1556 Dmel_neb_014630_0695_3361 EC051530 EC054490 EC054513 EC054518 EC055791 EK026918 EK100407 EK105419 EK208218 EK224521 EK242747 EN11761 EP11458 EP18255 ESG012b.E21.1_D05 ESG012b.E21.2_G10 ESG012b.TE.4_F09 ESG012c.E21_E01 ESG013b.E21_E03 ESG013b.E21_H06 ESG015c.E21_B08 ESG015c.E21.1_D10 ESG018b.E21_D03 ESG0113d.B21_H11 ESG0115b.B21_F12 ESG0120b.B21_B01 ESG0120c.B21_E06 GH26970 IP11507
RNAi & Array Information
Linkouts
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: A(225) CG18255 (Misra, 2000.4.6) Source for merge of: Mlc-k A(225) (Champagne et al., 2000) Source for merge of: Strn-Mlck BcDNA:RH74685 (FlyBase, 1996-) Source for merge of: Strn-Mlck BEST:GH22543 (Rana, 2004.7.8) Source for merge of: Strn-Mlck CG15699 (FlyBase Genome Annotators, 2012)
Additional comments	Annotations CG18255 and CG15699 merged as CG44162 in release 5.48 of the genome annotation. Merge supported by second tier modENCODE junction (FBrf0217580). (FlyBase Genome Annotators, 2012) FBrf0100232 discusses 'zetalin' but subsequent work revealed that the gene corresponding to cDNA with accession number U51473 is actually "Strn-Mlck". (Saide, 1997) Source for merge of Strn-Mlck BcDNA:RH74685 was a shared cDNA (date:030728). (FlyBase, 1996-)
Other Comments
	dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003) This locus can be viewed as a single transcription unit, Strn-Mlck, that expresses large, composite transcripts and protein isoforms, as well as a complex of two independent transcription units ("Strn" and "Mlck" respectively) the result of a "gene fission" event, that encode independent transcripts and proteins with distinct structural and enzymatic functions. (Champagne et al., 2000) Codes for a previously unidentified 225kD protein with repeating immunoglobulin C2-like domains that is associated with the A-band of myofibrils in indirect flight muscle. (Saide, 1999.10.29) A single Strn-Mlck gene produces multiple isoforms whose regulatory regions and expression patterns are different. These differences suggest various cellular functions of Strn-Mlck. (Kojima et al., 1996) Strn-Mlck-dependent phosphorylation of Mlc2 is not required for myofibrillogenesis or for the development of maximal isometric force in indirect flight muscles. (Tohtong et al., 1995)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_079030 NM_166128 NM_166129 NM_166130 NM_001202020 NM_001202023 NM_001202024 NM_001202026 NM_001274089 NM_001274090 RefSeq (Proteins) • NP_523754 NP_725509 NP_725510 NP_725511 NP_001188949 NP_001188952 NP_001188953 NP_001188955 NP_001261018 NP_001261019 DDBJ / EMBL / GenBank • AA264459 AA697372 AAA96526 AAF58086 AAF58087 AAF58089 AAF58090 AAF90108 AAF90109 AAF90110 AAF90111 AAF90112 AAF90113 AAF90114 AAF90115 AAF90116 AAF90117 AAF90118 AAF90119 AAF90120 AAF90124 AAF90125 AAF90126 AAF90127 AAF90128 AAF90129 AAF90130 AAF90131 AAG01794 AAG01795 AAG01796 AAG01797 AAG01798 AAG01799 AAL27639 AAM29651 AAM70936 AAM70937 AAM70938 AAM70939 AC004426 AC004516 ADV37194 ADV37195 ADV37196 ADV37197 ADV37198 ADV37199 ADV37200 ADV37201 ADV37202 AF254359 AF254360 AF254361 AF254362 AF254363 AF254364 AF254365 AF254366 AF254368 AF254369 AF254370 AF254371 AF254372 AF255667 AF255668 AF255669 AF255670 AF255671 AF255672 AF257306 AF257307 AF257308 AF257309 AF257310 AF257311 AF257312 AF257313 AGB93550 AGB93551 AI238593 AI388294 AI403054 AI403160 AI513718 AI513859 AI517150 AW940567 AW941074 AY061828 AY075340 AY113646 BAA19488 BAA19489 BAA20906 BG633424 BG633438 BI607592 CZ468267 CZ479695 CZ479929 CZ479930 CZ480093 CZ480094 CZ483954 CZ484684 CZ484685 CZ486864 CZ486865 D89661 D89662 D89663 U51473 Entrez Gene - A searchable database of RefSeq genes. • 36753 36756 UniProtKB/TrEMBL • A1ZA66 A1ZA67 A1ZA68 A1ZA69 A1ZA70 A1ZA72 A1ZA73 A1ZA74 O01651 O01652 O01653 Q8MYR8 Q9GTV0 Q9GTV1 Q9GV79 Q9GV80 Q9GV81 Q9GV82 Q9N6N9 Q9N630 Q9NBA9 Q9NBB0 Q9NBB1 Q9NBB2 Q9NBB3 Q9NBB4 Q9NBB6 Q9NBB7 Q9NBB8 Q9NBB9 Q9NBC0 Q9NBC1 Q9NBC2 Q9NBC3 Q9NBC4 Q9NBC5 Q9NBC6 Q95R30 Q24205
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Protein kinase, catalytic domain (IPR000719) Serine/threonine- / dual specificity protein kinase, catalytic domain (IPR002290) Immunoglobulin subtype 2 (IPR003598) Immunoglobulin subtype (IPR003599) Fibronectin, type III (IPR003961) Immunoglobulin-like domain (IPR007110) Serine/threonine-protein kinase, active site (IPR008271) Protein kinase-like domain (IPR011009) Immunoglobulin-like fold (IPR013783) Protein kinase, ATP binding site (IPR017441) Myosin light chain kinase-related (IPR020675) Immunoglobulin I-set (IPR013098) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • GH27795
Linkouts
Synonyms & Secondary IDs ( 31 )
Reported As
Symbol Synonym	143736_at (Kristensen et al., 2005) A(225) (Apidianakis et al., 2005, Patel and Saide, 2001, Zou et al., 2000, Saide, 1999.10.29, Saide, 1997, ) BcDNA:RH74685   BEST:GH22543   CG8304 (Morrison et al., 2000, ) CG15699 (Keleman et al., 2009.8.5) CG18255 (Ni et al., 2010.12.1, Vogel et al., 2003, Hickson et al., 2006, Ni et al., 2011.7.19, Perkins et al., 2009.3.31, Hughes et al., 2008, Perkins et al., 2009, Cammarato et al., 2011) CG44162 (FlyBase Genome Annotators, 2012) CT41348 (Ceriani et al., 2002, Hynes and Zhao, 2000) MLCK (Talbot and VanBerkum, 2005, Morrison et al., 2000, Rodriguez et al., 2000, Xu et al., 1998, Tesic et al., 1998, Kojima et al., 1996, Champagne et al., 1995, Takahashi et al., 1990, Takano-Ohmuro et al., 1990, Wong et al., 2008, Wong et al., 2007, Kim et al., 2009, Dorsten et al., 2010) mlck (Ward et al., 2003) Mlc-k (Iida and Akashi, 2000, Mukherjea et al., 1996, Tohtong et al., 1995, ) Mlck (Kojima et al., 1995, Hickson et al., 2006) MLCK-1 (Kojima, 1996.12.3) MLCK-2 (Kojima, 1996.12.3) MLCK-3 (Kojima, 1996.12.3) Strn-mlck (Kreuz et al., 2008) Strn-Mlck (Doroszuk et al., 2012, Japanese National Institute of Genetics, 2012.5.21, FlyBase Curators et al., 2004-, Zhou et al., 2009, Moser et al., 2010, Zacharogianni et al., 2011, Sathyanarayanan et al., 2008, Cardoso et al., 2006, Wasbrough et al., 2010, Schönbauer et al., 2011) strn-mlck (Jiang et al., 2011, Mattila et al., 2008) Strn-MLCK (Chechenova et al., 2013) unnamed (Vigoreaux, 2001)
Name Synonym	225kD protein   A-band-protein-225   MLC-kinase (Petit et al., 2002) myosin light chain kinase (Kreuz et al., 2008, Patel and Van Vactor, 2002, Halsell and Kiehart, 1998, Wong et al., 2007, Kim et al., 2009) Myosin light chain kinase (Kojima et al., 1995) Myosin Light Chain Kinase (Dorsten et al., 2010) Stretchin (Jacinto and Baum, 2003, Vogel et al., 2003) stretchin-MLCK (Champagne, 2000.4.7) Stretchin-Mlck (Champagne et al., 2000, Hickson et al., 2006, Burkart et al., 2007, Cammarato et al., 2011, ) Stretchin-MLCK (Vlachos and Harden, 2011, Sathyanarayanan et al., 2008)
Secondary FlyBase IDs
	FBgn0013988 FBgn0015845 FBgn0034055 FBgn0034056 FBgn0043813 FBgn0062898
References ( 104 )
Generate a list of	All references relating to this gene ( 104 )
List References by type	Research paper  ( 36 ) Supplementary material  ( 10 ) Review  ( 4 ) Personal communication to FlyBase  ( 22 ) Abstract  ( 12 ) FlyBase analysis  ( 4 ) Stock list  ( 1 ) DNA/RNA sequence record  ( 12 ) Curated genome annotation  ( 3 )
Recent research papers ( 7 )
	Chechenova et al., 2013, J. Biol. Chem. 288(6): 3718--3726 The Drosophila Z-disc Protein Z(210) Is an Adult Muscle Isoform of Zasp52, Which Is Required for Normal Myofibril Organization in Indirect Flight Muscles. [FBrf0220782] Doroszuk et al., 2012, BMC Genomics 13: 167 Transcriptome analysis of a long-lived natural Drosophila variant: a prominent role of stress- and reproduction-genes in lifespan extension. [FBrf0219259] Weber et al., 2012, PLoS ONE 7(4): e34745 Genome-Wide Association Analysis of Oxidative Stress Resistance in Drosophila melanogaster. [FBrf0218073] Jiang et al., 2011, Protein Cell 2(3): 215--222 Proteomic and transcriptomic analysis of visual long-term memory in Drosophila melanogaster. [FBrf0213377] Schönbauer et al., 2011, Nature 479(7373): 406--409 Spalt mediates an evolutionarily conserved switch to fibrillar muscle fate in insects. [FBrf0216735] Vlachos and Harden, 2011, Genetics 187(2): 501--512 Genetic Evidence for Antagonism Between Pak Protein Kinase and Rho1 Small GTPase Signaling in Regulation of the Actin Cytoskeleton During Drosophila Oogenesis. [FBrf0212983] Zacharogianni et al., 2011, EMBO J. 30(18): 3684--3700 ERK7 is a negative regulator of protein secretion in response to amino-acid starvation by modulating Sec16 membrane association. [FBrf0215221] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...