Spn4, sp4, serpin 4, Spn4A, Serine protease inhibitor 4
AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.48
Low-frequency RNA-Seq exon junction(s) not annotated.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Spn42Da using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signalsView Dmel\Spn42Da in GBrowse 2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
'Spn4' and 'Serp2' reports merged because: 'dSerp2' was mentioned in a single reference (FBrf0107050) as being similar to vertebrate 'neuroserpin' and that it maps to 42D-E. A later reference from the same author (FBrf0146814) says that 'neuroserpin' corresponds to CG9453/Spn4, a gene that has been mapped experimentally to 42D.
Overexpression of Spn4 either in the mesoderm or in peptidergic neurons results in animals which develop normally to the end of the first larval instar, but are unable to moult.
Identification: Identified on the basis of sequence similarity to serpins.