FlyBase Gene Report: Dmel\Spn42Da

General Information

Symbol

Dmel\Spn42Da

Species

D. melanogaster

Name

Serpin 42Da

Annotation Symbol

CG9453

Feature Type

protein_coding_gene

FlyBase ID

FBgn0265137

Gene Model Status

Current

Stock Availability

7 publicly available

Gene Summary

Serpin 42Da (Spn42Da) encodes an endopeptidase inhibitor involved in hormone processing regulation. [Date last reviewed: 2019-07-11] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
Interactive Fly

Also Known As

Spn4, sp4, Spn4A, serpin 4, Serine protease inhibitor 4

Key Links

Genomic Location

Cytogenetic map

42D-42D6

Sequence location

2R:6,875,906..6,878,927 [-]

Recombination map

2-55

RefSeq locus

NT_033778 REGION:6875906..6878927

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse GBrowse

Help me choose

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

Gene Ontology (GO) Annotations (6 terms)

Molecular Function (2 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

enables cysteine-type endopeptidase inhibitor activity

inferred from direct assay

(Bruning et al., 2007)

enables serine-type endopeptidase inhibitor activity

inferred from direct assay

(Bruning et al., 2007, Osterwalder et al., 2004, Richer et al., 2004)

Terms Based on Predictions or Assertions (0 terms)

Biological Process (3 terms)

Terms Based on Experimental Evidence (3 terms)

CV Term

Evidence

References

involved_in negative regulation of endopeptidase activity

inferred from direct assay

(Bruning et al., 2007, Osterwalder et al., 2004)

involved_in negative regulation of peptide hormone processing

inferred from mutant phenotype

(Osterwalder et al., 2004)

involved_in negative regulation of protein processing

inferred from mutant phenotype

(Osterwalder et al., 2004)

Terms Based on Predictions or Assertions (0 terms)

Cellular Component (1 term)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

located_in extracellular space

inferred from direct assay

(Bruning et al., 2007)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

is_active_in extracellular space

inferred from biological aspect of ancestor with PANTHER:PTN000156123

(assigned by GO_Central )

(Gaudet et al., 2011)

Gene Group (FlyBase)

INHIBITORY SERPINS

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Snapshot

Serpin 42Da (Spn42Da) encodes an endopeptidase inhibitor involved in hormone processing regulation. [Date last reviewed: 2019-07-11]

Gene Group (FlyBase)

INHIBITORY SERPINS -: The serpin family is a structurally-related group of secreted proteins containing the serpin-fold, a 350-400 amino acid domain. Serpins (SERine Protease INhibitors) were first identified as a set of proteins able to inhibit proteases, acting by forming a covalent complex is formed with the target proteinase targeting it for degradation. (Adapted from FBrf0213937 and FBrf0209216).

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Spn42Da for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Comments on Gene Model

Gene model reviewed during 5.48

Low-frequency RNA-Seq exon junction(s) not annotated.

Sequence Ontology: Class of Gene

gene

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Spn42Da-RA

FBtr0086197

NM_165496

1505

392

Spn42Da-RB

FBtr0086196

NM_080216

1385

424

Spn42Da-RD

FBtr0086198

NM_206039

1531

411

Spn42Da-RE

FBtr0086199

NM_206038

1643

411

Spn42Da-RF

FBtr0086200

NM_206037

1669

411

Spn42Da-RG

FBtr0086201

NM_206036

1651

379

Spn42Da-RH

FBtr0086202

NM_206035

1763

379

Spn42Da-RI

FBtr0086203

NM_206034

1370

406

Spn42Da-RJ

FBtr0086204

NM_206033

1490

374

Spn42Da-RK

FBtr0086205

NM_206032

1789

379

Spn42Da-RL

FBtr0300336

NM_165495

2155

379

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

Spn42Da-PA

FBpp0085524

44.1

392

5.94

NP_724512

AAG22209

Spn42Da-PB

FBpp0085523

47.7

424

5.91

NP_524955

AAG22208

Spn42Da-PD

FBpp0089189

46.0

411

6.59

NP_995761

AAS64784

Spn42Da-PE

FBpp0089190

46.2

411

6.51

NP_995760

AAS64786

Spn42Da-PF

FBpp0089191

46.2

411

6.51

NP_995759

AAS64787

Spn42Da-PG

FBpp0089192

42.4

379

6.69

NP_995758

AAS64785

Spn42Da-PH

FBpp0089193

42.7

379

6.59

NP_995757

AAS64788

Spn42Da-PI

FBpp0089207

45.6

406

7.01

NP_995756

AAS64782

Spn42Da-PJ

FBpp0089208

42.1

374

7.18

NP_995755

AAS64783

Spn42Da-PK

FBpp0089206

42.7

379

6.59

NP_995754

AAS64789

Spn42Da-PL

FBpp0289565

42.7

379

6.59

NP_724511

AAF57405

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

411 aa isoforms: Spn42Da-PE, Spn42Da-PF

379 aa isoforms: Spn42Da-PH, Spn42Da-PK, Spn42Da-PL

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Spn42Da using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Linkouts

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 4 -- 6

organism | faint | ubiquitous

(Fisher et al., 2012)

embryonic stage 9 -- 10

dorsal ectoderm

(Fisher et al., 2012)

embryonic stage 11 -- 12

amnioserosa

(Fisher et al., 2012)

dorsal epidermis primordium

(Fisher et al., 2012)

ventral epidermis primordium

(Fisher et al., 2012)

yolk nucleus

(Fisher et al., 2012)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

day 7 of adulthood -- day 49 of adulthood

adult heart

(Cammarato et al., 2011)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in extracellular space

inferred from direct assay

(Bruning et al., 2007)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Spn42Da in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Spn42Da

View exonic expression by tissue for Dmel\Spn42Da

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0265137

DRscDB

49805/tissue=All

EMBL-EBI Single Cell Expression Atlas

FBgn0265137

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG9453

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 3 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 9 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Spn42Da

Transgenic constructs containing regulatory region of Spn42Da

Aberrations (Deficiencies and Duplications) ( 1 )

Inferred from experimentation ( 1 )

Gene disrupted in

Df(2R)Exel6051

(Ryder, 2004.4.26)

Inferred from location ( 0 )

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal, with Scer\GAL4^pnr-MD237

Spn42Da^GD3481

lethal | larval stage, with Scer\GAL4^dimm-929

Spn42Da^4.1.UAS

lethal | pupal stage, with Scer\GAL4^dimm-929

Spn42Da^4.1.UAS

lethal - all die before end of larval stage, with Scer\GAL4^how-24B

Spn42Da^4.1.UAS

partially lethal, with Scer\GAL4^tin.CΔ4

Spn42Da^GD3481

viable

Spn42Da^d08261

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Spn42Da^GD3481

viable, with Scer\GAL4^Mef2.PR

Spn42Da^GD3481

Sterility

Allele

fertile

Spn42Da^d08261

Other Phenotypes

Allele

abnormal pain response | adult stage, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Spn42Da^GD3481

some die during larval stage, with Scer\GAL4^how-24B

Spn42Da^4.1.UAS

Phenotype manifest in

Allele

cephalopharyngeal skeleton, with Scer\GAL4^dimm-929

Spn42Da^4.1.UAS

cephalopharyngeal skeleton, with Scer\GAL4^how-24B

Spn42Da^4.1.UAS

Orthologs

Downloads

Download All DIOPT Orthologs

Download All OrthoDB Orthologs

Human Orthologs (via DIOPT v8.0)

Homo sapiens (Human) (38)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Hsap\SERPINI1

10 of 15

Yes

Hsap\SERPINI2

7 of 15

Yes

6 of 15

5 of 15

5 of 15

4 of 15

4 of 15

4 of 15

4 of 15

4 of 15

Yes

Hsap\SERPINA4

3 of 15

Yes

3 of 15

3 of 15

3 of 15

3 of 15

Yes

Hsap\SERPINE3

3 of 15

Yes

Hsap\HMSD

2 of 15

Hsap\SERPINA6

2 of 15

Hsap\SERPINA7

2 of 15

Yes

2 of 15

2 of 15

2 of 15

2 of 15

1 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Yes

Hsap\SERPINH1

1 of 15

Model Organism Orthologs (via DIOPT v8.0)

Mus musculus (laboratory mouse) (64)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Mmus\Serpini1

10 of 15

Yes

Mmus\Serpinb1a

7 of 15

Mmus\Serpinb1b

7 of 15

Mmus\Serpini2

7 of 15

Yes

6 of 15

6 of 15

6 of 15

5 of 15

5 of 15

5 of 15

5 of 15

5 of 15

5 of 15

5 of 15

5 of 15

5 of 15

5 of 15

5 of 15

5 of 15

Yes

4 of 15

4 of 15

4 of 15

4 of 15

4 of 15

4 of 15

4 of 15

Yes

3 of 15

3 of 15

3 of 15

3 of 15

Yes

Mmus\Serpine3

3 of 15

Yes

Mmus\Serpina1f

2 of 15

Yes

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

Yes

Mmus\Agt

1 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Yes

Mmus\Serpinh1

1 of 15

Rattus norvegicus (Norway rat) (51)

Rnor\Serpini1

9 of 13

Yes

Rnor\Serpini2

6 of 13

Yes

Rnor\Serpinb1a

5 of 13

Rnor\Serpinb1b

4 of 13

Yes

4 of 13

4 of 13

4 of 13

4 of 13

4 of 13

4 of 13

Yes

Rnor\LOC100911107

3 of 13

Rnor\Serpina9

3 of 13

Yes

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

Yes

Rnor\Serpine1

3 of 13

Yes

Rnor\LOC299282

2 of 13

Yes

Rnor\LOC100909605

2 of 13

Yes

Rnor\LOC102553010

2 of 13

Rnor\RGD1564786

2 of 13

Yes

Rnor\Serpina1f

2 of 13

Yes

Rnor\Serpina4

2 of 13

Rnor\Serpina6

2 of 13

Rnor\Serpina16

2 of 13

Yes

Rnor\Serpinb2

2 of 13

Rnor\Serpinb3

2 of 13

Yes

Rnor\Serpinb6e

2 of 13

Yes

Rnor\Serpinb11

2 of 13

Rnor\Serpind1

2 of 13

Yes

Rnor\Serpine3

2 of 13

Yes

Rnor\Agt

1 of 13

Yes

Rnor\LOC299277

1 of 13

Rnor\LOC103690041

1 of 13

Yes

Rnor\RGD1562844

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Rnor\Serping1

1 of 13

Yes

Rnor\Serpinh1

1 of 13

Xenopus tropicalis (Western clawed frog) (17)

Xtro\serpini1

6 of 12

Yes

Xtro\serpinb1

5 of 12

Xtro\serpinb6

3 of 12

Yes

Xtro\serpinc1

3 of 12

Xtro\serpine1

3 of 12

Yes

Xtro\serpine2

3 of 12

Yes

Xtro\serpini2

3 of 12

Yes

Xtro\serpinb4

2 of 12

Xtro\serpinb10

2 of 12

Yes

Xtro\serpinb11

2 of 12

Xtro\serpind1

2 of 12

Yes

Xtro\serpina10

1 of 12

Yes

Xtro\serpinb5

1 of 12

Xtro\serpine3

1 of 12

Yes

Xtro\serpinf1

1 of 12

Xtro\serpinf2

1 of 12

Xtro\serpinh1

1 of 12

Danio rerio (Zebrafish) (30)

Drer\serpinb1l2

8 of 15

Yes

Drer\serpini1

8 of 15

Yes

7 of 15

6 of 15

5 of 15

4 of 15

4 of 15

4 of 15

4 of 15

Yes

Drer\zgc:173729

4 of 15

Drer\serpine1

3 of 15

Yes

Drer\serpine3

3 of 15

Yes

Drer\LOC569077

2 of 15

Yes

Drer\serpind1

2 of 15

Yes

Drer\si:ch211-186e20.7

2 of 15

Yes

Drer\agt

1 of 15

Drer\LOC110439158

1 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Yes

Drer\serpinf1

1 of 15

Yes

Drer\serpinf2a

1 of 15

Drer\serpinf2b

1 of 15

Yes

Drer\serping1

1 of 15

Yes

Drer\serpinh1a

1 of 15

Drer\serpinh1b

1 of 15

Drer\si:ch1073-416d2.3

1 of 15

Drer\zgc:174259

1 of 15

Caenorhabditis elegans (Nematode, roundworm) (8)

Cele\srp-6

10 of 15

Yes

9 of 15

9 of 15

8 of 15

7 of 15

6 of 15

1 of 15

Yes

Cele\srp-5

1 of 15

Arabidopsis thaliana (thale-cress) (12)

Atha\AT1G62170

7 of 9

Yes

Atha\CCP3

7 of 9

Yes

Atha\SERPIN1

7 of 9

Yes

Atha\SRP2

7 of 9

Yes

Atha\SRP3

7 of 9

Yes

6 of 9

6 of 9

6 of 9

3 of 9

2 of 9

1 of 9

Yes

Atha\AT1G63280

1 of 9

Yes

Saccharomyces cerevisiae (Brewer's yeast) (0)

No records found.

Schizosaccharomyces pombe (Fission yeast) (0)

No records found.

Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG09190CL1 )

Organism

Common Name

Gene

AAA Syntenic Ortholog

Multiple Dmel Genes in this Orthologous Group

Drosophila simulans

Drosophila sechellia

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Dpse\GA24549

Drosophila persimilis

Dper\GL10965

Drosophila willistoni

Dwil\GK20759

Drosophila willistoni

Dwil\GK20758

Drosophila willistoni

Dwil\GK20760

Drosophila willistoni

Dwil\GK20757

Drosophila virilis

Dvir\GJ18486

Drosophila mojavensis

Dmoj\GI19810

Drosophila grimshawi

Dgri\GH19862

Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG0915082T )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Musca domestica

House fly

Mdoa\17009972

Musca domestica

House fly

Mdoa\17023054

Musca domestica

House fly

Mdoa\17023061

Musca domestica

House fly

Mdoa\17023048

Musca domestica

House fly

Mdoa\17023058

Musca domestica

House fly

Mdoa\17023056

Musca domestica

House fly

Mdoa\17023060

Musca domestica

House fly

Mdoa\17023053

Musca domestica

House fly

Mdoa\17023059

Musca domestica

House fly

Mdoa\17009973

Glossina morsitans

Tsetse fly

Gmor\GMOY002443

Glossina morsitans

Tsetse fly

Gmor\GMOY012007

Lucilia cuprina

Australian sheep blowfly

Lcup\FF38_09968

Lucilia cuprina

Australian sheep blowfly

Lcup\FF38_01697

Mayetiola destructor

Hessian fly

Mdes\Mdes008742

Mayetiola destructor

Hessian fly

Mdes\Mdes005415

Aedes aegypti

Yellow fever mosquito

Aaeg\SRPN10

Anopheles darlingi

American malaria mosquito

Adar\ADAC002817

Anopheles darlingi

American malaria mosquito

Adar\ADAC003360

Anopheles darlingi

American malaria mosquito

Adar\ADAC006056

Anopheles darlingi

American malaria mosquito

Adar\ADAC002818

Anopheles darlingi

American malaria mosquito

Adar\ADAC001469

Anopheles gambiae

Malaria mosquito

Agam\spi21F

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ014719

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ014718

Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0C0B )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Bombyx mori

Silkmoth

Bmor\BGIBMGA009953

Bombyx mori

Silkmoth

Bmor\BGIBMGA004726

Bombyx mori

Silkmoth

Bmor\BGIBMGA010216

Bombyx mori

Silkmoth

Bmor\BGIBMGA007720

Danaus plexippus

Monarch butterfly

Dple\DPOGS204415-PA

Danaus plexippus

Monarch butterfly

Dple\DPOGS202454-PA

Danaus plexippus

Monarch butterfly

Dple\DPOGS202455-PA

Danaus plexippus

Monarch butterfly

Dple\DPOGS204417-PA

Danaus plexippus

Monarch butterfly

Dple\DPOGS210152-PA

Danaus plexippus

Monarch butterfly

Dple\DPOGS204418-PA

Danaus plexippus

Monarch butterfly

Dple\DPOGS202453-PA

Heliconius melpomene

Postman butterfly

Hmel\HMEL017304

Heliconius melpomene

Postman butterfly

Hmel\HMEL007476

Heliconius melpomene

Postman butterfly

Hmel\HMEL008146

Heliconius melpomene

Postman butterfly

Hmel\HMEL006260

Apis florea

Little honeybee

Aflo\4148178708

Apis florea

Little honeybee

Aflo\3306191780

Apis mellifera

Western honey bee

Amel\GB46970

Apis mellifera

Western honey bee

Amel\GB48820

Bombus impatiens

Common eastern bumble bee

Bimp\BIMP18434

Bombus impatiens

Common eastern bumble bee

Bimp\BIMP18422

Bombus impatiens

Common eastern bumble bee

Bimp\BIMP18423

Bombus terrestris

Buff-tailed bumblebee

Bter\15212736

Bombus terrestris

Buff-tailed bumblebee

Bter\15202674

Bombus terrestris

Buff-tailed bumblebee

Bter\15212734

Bombus terrestris

Buff-tailed bumblebee

Bter\15212706

Bombus terrestris

Buff-tailed bumblebee

Bter\15212735

Linepithema humile

Argentine ant

Lhum\LH24668

Linepithema humile

Argentine ant

Lhum\LH26242

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:001524

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:0021cd

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:0021cb

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:0021cc

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:003083

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG007817

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG004051

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG007825

Dendroctonus ponderosae

Mountain pine beetle

Dpod\YQE_10775

Dendroctonus ponderosae

Mountain pine beetle

Dpod\YQE_07270

Tribolium castaneum

Red flour beetle

Tcas\serpin23

Tribolium castaneum

Red flour beetle

Tcas\serpin29

Tribolium castaneum

Red flour beetle

Tcas\TC030935

Tribolium castaneum

Red flour beetle

Tcas\TC034058

Tribolium castaneum

Red flour beetle

Tcas\TC034678

Tribolium castaneum

Red flour beetle

Tcas\serpin18

Tribolium castaneum

Red flour beetle

Tcas\TC005754

Tribolium castaneum

Red flour beetle

Tcas\serpin24

Tribolium castaneum

Red flour beetle

Tcas\serpin1

Tribolium castaneum

Red flour beetle

Tcas\TC034133

Tribolium castaneum

Red flour beetle

Tcas\serpin7

Tribolium castaneum

Red flour beetle

Tcas\TC034061

Tribolium castaneum

Red flour beetle

Tcas\TC034059

Tribolium castaneum

Red flour beetle

Tcas\serpin19

Tribolium castaneum

Red flour beetle

Tcas\serpin31

Pediculus humanus

Human body louse

Phum\PHUM106690

Pediculus humanus

Human body louse

Phum\PHUM220550

Pediculus humanus

Human body louse

Phum\PHUM106570

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI005016

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI060557

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI004935

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI007530

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI000344

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI006911

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI004123

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI008381

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI002244

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI008775

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_11231

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_11095

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_07264

Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0BBK )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strigamia maritima

European centipede

Smar\SMAR003048

Strigamia maritima

European centipede

Smar\SMAR003045

Strigamia maritima

European centipede

Smar\SMAR004057

Strigamia maritima

European centipede

Smar\SMAR003087

Strigamia maritima

European centipede

Smar\SMAR001099

Ixodes scapularis

Black-legged tick

Isca\ISCW024495

Ixodes scapularis

Black-legged tick

Isca\ISCW011013

Ixodes scapularis

Black-legged tick

Isca\ISCW005088

Ixodes scapularis

Black-legged tick

Isca\ISCW000427

Ixodes scapularis

Black-legged tick

Isca\ISCW024109

Ixodes scapularis

Black-legged tick

Isca\ISCW004156

Ixodes scapularis

Black-legged tick

Isca\ISCW023620

Ixodes scapularis

Black-legged tick

Isca\ISCW024046

Ixodes scapularis

Black-legged tick

Isca\ISCW024387

Ixodes scapularis

Black-legged tick

Isca\ISCW023618

Ixodes scapularis

Black-legged tick

Isca\ISCW024435

Ixodes scapularis

Black-legged tick

Isca\ISCW011017

Ixodes scapularis

Black-legged tick

Isca\ISCW024500

Ixodes scapularis

Black-legged tick

Isca\ISCW023622

Ixodes scapularis

Black-legged tick

Isca\ISCW023621

Ixodes scapularis

Black-legged tick

Isca\ISCW018607

Ixodes scapularis

Black-legged tick

Isca\ISCW023623

Ixodes scapularis

Black-legged tick

Isca\ISCW014652

Ixodes scapularis

Black-legged tick

Isca\ISCW009616

Ixodes scapularis

Black-legged tick

Isca\ISCW023619

Ixodes scapularis

Black-legged tick

Isca\ISCW015204

Stegodyphus mimosarum

African social velvet spider

Smim\KFM58371.1

Stegodyphus mimosarum

African social velvet spider

Smim\KFM76460.1

Stegodyphus mimosarum

African social velvet spider

Smim\KFM58296.1

Stegodyphus mimosarum

African social velvet spider

Smim\KFM62677.1

Stegodyphus mimosarum

African social velvet spider

Smim\KFM58368.1

Stegodyphus mimosarum

African social velvet spider

Smim\KFM58369.1

Stegodyphus mimosarum

African social velvet spider

Smim\KFM71492.1

Stegodyphus mimosarum

African social velvet spider

Smim\KFM58370.1

Tetranychus urticae

Two-spotted spider mite

Turt\tetur10g04810

Tetranychus urticae

Two-spotted spider mite

Turt\tetur08g03770

Tetranychus urticae

Two-spotted spider mite

Turt\tetur01g02260

Tetranychus urticae

Two-spotted spider mite

Turt\tetur10g04790

Tetranychus urticae

Two-spotted spider mite

Turt\tetur128g00060

Tetranychus urticae

Two-spotted spider mite

Turt\tetur10g04760

Tetranychus urticae

Two-spotted spider mite

Turt\tetur10g04770

Tetranychus urticae

Two-spotted spider mite

Turt\tetur10g04780

Tetranychus urticae

Two-spotted spider mite

Turt\tetur10g04820

Tetranychus urticae

Two-spotted spider mite

Turt\tetur128g00030

Tetranychus urticae

Two-spotted spider mite

Turt\tetur128g00020

Tetranychus urticae

Two-spotted spider mite

Turt\tetur18g03300

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_63029

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_53805

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_189444

Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0ION )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-SerpL1

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-SerpL4

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-SerpL2

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-SerpL7

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-SerpL12

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-SerpL5

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-SerpL11

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-SerpL3

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-SerpL8

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-SerpL10

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-SerpL6

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-SerpL9

Ciona intestinalis

Vase tunicate

Cint\not2

Ciona intestinalis

Vase tunicate

Cint\LOC100177061

Ciona intestinalis

Vase tunicate

Cint\LOC100179418

Ciona intestinalis

Vase tunicate

Cint\LOC100176269

Ciona intestinalis

Vase tunicate

Cint\ENSCING00000019069

Ciona intestinalis

Vase tunicate

Cint\LOC100182186

Gallus gallus

Domestic chicken

Ggal\SERPINE2

Gallus gallus

Domestic chicken

Ggal\SERPINC1

Gallus gallus

Domestic chicken

Ggal\SERPINB10

Gallus gallus

Domestic chicken

Ggal\SERPINE3

Gallus gallus

Domestic chicken

Ggal\SERPINB1

Gallus gallus

Domestic chicken

Ggal\SERPINB12

Gallus gallus

Domestic chicken

Ggal\ENSGALG00000028598

Gallus gallus

Domestic chicken

Ggal\SERPINBP1

Gallus gallus

Domestic chicken

Ggal\SERPINB5

Gallus gallus

Domestic chicken

Ggal\SERPINB14

Gallus gallus

Domestic chicken

Ggal\SERPINA3

Gallus gallus

Domestic chicken

Ggal\SERPINB10

Gallus gallus

Domestic chicken

Ggal\SERPIND1

Gallus gallus

Domestic chicken

Ggal\SERPINI1

Gallus gallus

Domestic chicken

Ggal\SERPINA9

Gallus gallus

Domestic chicken

Ggal\SERPINA5

Gallus gallus

Domestic chicken

Ggal\SERPINB2

Gallus gallus

Domestic chicken

Ggal\SERPINA1

Gallus gallus

Domestic chicken

Ggal\ENSGALG00000020391

Gallus gallus

Domestic chicken

Ggal\SERPINB6

Gallus gallus

Domestic chicken

Ggal\ENSGALG00000010969

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v8.0)

Drosophila melanogaster (Fruit fly) (29)

Gene Symbol

Score

Source

Alignment

8 of 10

8 of 10

7 of 10

7 of 10

7 of 10

6 of 10

6 of 10

6 of 10

6 of 10

6 of 10

6 of 10

5 of 10

5 of 10

5 of 10

nec

4 of 10

4 of 10

4 of 10

3 of 10

3 of 10

3 of 10

3 of 10

3 of 10

3 of 10

2 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 1 )

Human Ortholog

Disease

Evidence

References

SERPINI1; serpin family I member 1

model of familial encephalopathy with neuroserpin inclusion bodies

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

SERPINI1; serpin family I member 1

10 of 15

602445

ENCEPHALOPATHY, FAMILIAL, WITH NEUROSERPIN INCLUSION BODIES; FENIB

familial encephalopathy with neuroserpin inclusion bodies

SERPINI2; serpin family I member 2

7 of 15

605587

SERPINB1; serpin family B member 1

6 of 15

130135

SERPINB3; serpin family B member 3

5 of 15

600517

SERPINB6; serpin family B member 6

5 of 15

173321

DEAFNESS, AUTOSOMAL RECESSIVE 91; DFNB91

autosomal recessive nonsyndromic deafness 91

SERPINB4; serpin family B member 4

4 of 15

600518

SERPINB9; serpin family B member 9

4 of 15

601799

SERPINB10; serpin family B member 10

4 of 15

602058

SERPINB13; serpin family B member 13

4 of 15

604445

SERPINE2; serpin family E member 2

4 of 15

177010

SERPINA4; serpin family A member 4

3 of 15

147935

SERPINB8; serpin family B member 8

3 of 15

601697

PEELING SKIN SYNDROME 5; PSS5

SERPINB12; serpin family B member 12

3 of 15

615662

SERPINC1; serpin family C member 1

3 of 15

107300

ANTITHROMBIN III DEFICIENCY; AT3D

antithrombin III deficiency

SERPINE1; serpin family E member 1

3 of 15

173360

PLASMINOGEN ACTIVATOR INHIBITOR-1 DEFICIENCY

SERPINE3; serpin family E member 3

3 of 15

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

View in Interactions Browser

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

Spn42Da - Nrd1

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Yoon et al., 2017)

Summary of Genetic Interactions

esyN Network Diagram

esyN Network Key:

Suppression

Enhancement

View in Interactions Browser

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

norpA

suppressible

Spn42Da

(Kinser and Dolph, 2012)

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0265137

MIST (protein-protein) - An integrated Molecular Interaction Database

Spn42Da

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

External Data

Linkouts

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-55

Cytogenetic map

42D-42D6

Sequence location

2R:6,875,906..6,878,927 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

42D-42D6

Left limit from in situ hybridisation (FBrf0107050) Right limit from in situ hybridisation (FBrf0107050); Limits computationally determined from genome sequence between P{lacW}ubl^k03203&P{PZ}CG3287⁰⁹⁹⁶⁷ and P{EP}EP2303&P{EP}EP2105

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

42D1-42D5

(determined by in situ hybridisation)

(Han et al., 2000)

42D-42E

(determined by in situ hybridisation)

(Osterwalder et al., 1999)

Experimentally Determined Recombination Data

Location

2-55

(FlyBase, 2016)

2-56.1

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (7)

Bloomington

19291

w¹¹¹⁸; P{XP}Spn42Da^d08261

41613

y¹ v¹; P{TRiP.GL01195}attP40

31979

y¹ v¹; P{TRiP.JF03413}attP2/TM3, Sb¹

41722

y¹ sc^* v¹ sev²¹; P{TRiP.HMS02288}attP2

VDRC

v106306

P{KK107708}VIE-260B

v40973

w¹¹¹⁸; P{GD3481}v40973

v318090

PBac{fTRG00430.sfGFP-TVPTBF}VK00033

Genomic Clones (21)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (94)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0265137

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

RNAi and Array Information

Linkouts

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

49805

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Osterwalder et al., 2004)

Commercially Available Antibodies

Other Information

Relationship to Other Genes

Source for database identify of

Source for identity of: Spn4 neuroserpin

(Osterwalder, 2002.3.25)

Source for identity of: Spn42Da Spn4

(Hashimoto et al., 2012.10.8)

Source for database merge of

Source for merge of: sp4 CG9453

(Bayraktaroglu, 2000.8.7)

Source for merge of: Spn4 Serp2

(FlyBase, 1992-)

Additional comments

'Spn4' and 'Serp2' reports merged because: 'dSerp2' was mentioned in a single reference (FBrf0107050) as being similar to vertebrate 'neuroserpin' and that it maps to 42D-E. A later reference from the same author (FBrf0146814) says that 'neuroserpin' corresponds to CG9453/Spn4, a gene that has been mapped experimentally to 42D.

(FlyBase, 1992-)

Other Comments

Overexpression of Spn4 either in the mesoderm or in peptidergic neurons results in animals which develop normally to the end of the first larval instar, but are unable to moult.

(Osterwalder et al., 2002)

Identification: Identified on the basis of sequence similarity to serpins.

(Osterwalder et al., 1999)

Origin and Etymology

Discoverer

Etymology

Identification

External Crossreferences and Linkouts ( 102 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

49805

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0265137

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0265137

DRscDB

49805/tissue=All

EMBL-EBI Single Cell Expression Atlas

FBgn0265137

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG9453

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

49805

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

Dmel_CG9453

MARRVEL_MODEL

49805

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0265137

MIST (protein-protein) - An integrated Molecular Interaction Database

Spn42Da

Synonyms and Secondary IDs (15)

Reported As

Symbol Synonym

CG9453

(Kim et al., 2021, Hosono et al., 2015, Cammarato et al., 2011, Ni et al., 2010.12.1, Garrett et al., 2009, Keleman et al., 2009.8.5, Perkins et al., 2009, Richer et al., 2004, De Gregorio et al., 2001)

Serp2

Sp4

(Christophides et al., 2002, De Gregorio et al., 2001)

Spn4

(Sarov et al., 2016, Sfaxi et al., 2014, Gendrin et al., 2013, Handke et al., 2013, Short and Lazzaro, 2013, Stefanatos et al., 2013, Garelli et al., 2012, Japanese National Institute of Genetics, 2012.5.21, Ahmad et al., 2009, Buchon et al., 2009, Bruning et al., 2007, Kim et al., 2007, Osterwalder et al., 2004, Hashimoto et al., 2003)

Spn42Da

(Jeon et al., 2020, Yoon et al., 2017, Hashimoto et al., 2012.10.8, Reichhart et al., 2011, Garrett et al., 2009)

Spn4A

(Meekins et al., 2017, Sfaxi et al., 2014, Richer et al., 2004)

dSerp2

(Osterwalder et al., 1999)

sp4

(van Steensel et al., 2003, Kruger et al., 2002, Han et al., 2000)

spn4

(Börner and Ragg, 2008)

Name Synonyms

Serine protease inhibitor 4

(Cammarato et al., 2011, Osterwalder et al., 2004)

Serp2

Serpin 4

(Kinser and Dolph, 2012)

Serpin 42 Da

(Meekins et al., 2017)

Serpin 42Da

(Hashimoto et al., 2012.10.8)

neuroserpin

(Osterwalder et al., 2002)

serpin 4

(Kinser and Dolph, 2012, Han et al., 2000)

Secondary FlyBase IDs

FBgn0028985
FBgn0033111
FBgn0026360

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

References (75)

Report Sections

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