Spn4, sp4, serpin 4, Spn4A, Serine protease inhibitor 4
Please see the JBrowse view of Dmel\Spn42Da for information on other features
To submit a correction to a gene model please use the Contact FlyBase form
Gene model reviewed during 5.48
Low-frequency RNA-Seq exon junction(s) not annotated.
The group(s) of polypeptides indicated below share identical sequence to each other.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Spn42Da using the Feature Mapper tool.
Comment: maternally deposited
GBrowse - Visual display of RNA-Seq signals
View Dmel\Spn42Da in GBrowse 22-55
2-55
2-56.1
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
polyclonal
Source for identity of: Spn4 neuroserpin
Source for identity of: Spn42Da Spn4
Source for merge of: sp4 CG9453
Source for merge of: Spn4 Serp2
'Spn4' and 'Serp2' reports merged because: 'dSerp2' was mentioned in a single reference (FBrf0107050) as being similar to vertebrate 'neuroserpin' and that it maps to 42D-E. A later reference from the same author (FBrf0146814) says that 'neuroserpin' corresponds to CG9453/Spn4, a gene that has been mapped experimentally to 42D.
Overexpression of Spn4 either in the mesoderm or in peptidergic neurons results in animals which develop normally to the end of the first larval instar, but are unable to moult.
Identification: Identified on the basis of sequence similarity to serpins.