• Home
• Tools
  • Tools Overview
  • Query Tools

    
    • QuickSearch
    • QueryBuilder
    • TermLink
    • CytoSearch
    • RNA-Seq Search
    • Interactions Browser
    • ImageBrowse
    • Find A Person
    • Google™ FlyBase
  • Genomic/Map Tools

    
    • BLAST
    • GBrowse
    • GBrowse 2 Beta
    • CytoSearch
    • Feature Mapper
    • Aberrations Maps
    • Chromosome Maps
    • Coordinates Converter
  • Retrieve/Convert

    
    • Batch Download
    • Coordinates Converter
    • ID Converter
  • Data Submission

    
    • Fast-Track Your Paper
    • Submit Personal Comm
    • Add A New Person
    • Update Person Info
  • People

    
    • Find A Person
    • Add A New Person
    • Update Person Info
• Files
  • Files Overview
  • Current release
  • Archived releases
  • Map Conversion
  • FTP site:
  • Releases (FTP)
  • Genomes (FTP)
• Species
  • Phylogeny
  • Sequenced Species
  • Synteny Table
  • Color Illustrations
  • Abbreviations
• Documents
  • About FlyBase
  • Reference Manual:
  • Sections
  • Contents
  • Nomenclature
  • Release Notes
• Resources
  • All Resources
  • Model Organisms
  • Stock Collections
  • Vectors & Constructs
  • Other links:
  • BDGP
  • DGRC
  • DIS by issue
  • FlyExpress
  • Interactive Fly
  • modENCODE
  • Textpresso for Fly
• News
  • News
  • FlyBase Forum
  • FlyBase Positions
  • Meetings
  • Courses
  • Fly Board
  • White papers
  • Funding
  • bionet.dros
• Help
  • Google™ FlyBase
  • Site Map
  • FAQs
  • FlyBase Guides
  • Video Tutorials
  • Report help
  • New to Flies
  • Pers. comm.
  • Author guidelines
  • Contact FlyBase
• Archives
  • Prior Release
  • Other Archives
  • Coordinate Converter

Gene Dmel\Meltrin

General Information
Symbol	Dmel\Meltrin	Species	D. melanogaster
Name	Meltrin	Annotation symbol	CG7649
Feature type	protein_coding_gene	FlyBase ID	FBgn0265140
Gene Model Status	Current	Stock availability	26 publicly available
Also Known As	Neu3, CT23341
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	88C10-88D1	Sequence location	3R:10,491,559..10,523,057 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Meltrin is referred to in FlyBase by the symbol Dmel\Meltrin (CG7649, FBgn0265140). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: identical protein binding; metalloendopeptidase activity. There is experimental evidence that it is involved in the biological process: membrane protein ectodomain proteolysis; protein oligomerization. 29 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: ADAM, cysteine-rich; Blood coagulation inhibitor, Disintegrin; EGF-like, conserved site; Epidermal growth factor-like domain; Metallopeptidase, catalytic domain; Peptidase M12B, ADAM/reprolysin; Peptidase M12B, propeptide. Gene sequence location is 3R:10491559..10523057.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 88C10-88D1
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Meltrin for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Meltrin-RC FBtr0301498  NM_001032403   4954   1407 Meltrin-RD FBtr0301499  NM_001032404   4148   975
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Meltrin-PC   FBpp0290713   151.7   1407   7.98     NP_001027575   AAZ83995 Meltrin-PD   FBpp0290714   107.3   975   7.01     NP_001027576   AAZ83996
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Epidermal growth factor-like domain (IPR000742) Peptidase M12B, ADAM/reprolysin (IPR001590) Blood coagulation inhibitor, Disintegrin (IPR001762) Peptidase M12B, propeptide (IPR002870) ADAM, cysteine-rich (IPR006586) EGF-like, conserved site (IPR013032) Metallopeptidase, catalytic domain (IPR024079)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA696330   AA990831   AE014297 AAZ83995   AE014297 AAZ83996   AI238287   AI293908   AI532097   AI532409   AI532545   AI532555   AI532923   AI543112   AI544262   AW944333   AY095096 AAM11424   AY525769 AAS48651   BE977686   BG632809   BG639663   BI141897   BI167630   BI216127   BI370200   BI566180   BI588653   BI589176   BI625138   BI633041   BI635581   BI636380   BI638971   BI639772   BI640337   BP548811   BP549002   BT001804   BT003436 AAO39439   BT011467   CO155069   CO157061   CO187417   CO196330   CO196611   CO262594   CO277709   CO281444   CO282342   CO311174   CO313831   CO317935   CO335664   CO341577   CO343906   CZ467576   EC061960   EC063299   EC066597   EC066719   EC073505   EC081857   EC214072   EC248091   EC252206   EC258533   EC261052   EC261348   EC267683   ES690313   GH749976   GH750556   GH755554   GH776624   GH800412   GH807232   GH807548   GH811863   GH818154   GH824083   GH829843   GH839493   GH840876   GH847987   GH851539   GH857087   GH857768   GH866734   GH868246   GH868383   GH872588   GH895455   GH912325   GH933958
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q6QU65 Q400M8 Q8T3I9 Q86P79
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism   (Fisher et al., 2012) Comment:maternally deposited blastoderm stage   ventral ectoderm anlage   (Stathopoulos et al., 2002) embryonic stage 4 -- 6   clypeo-labral anlage in statu nascendi   (Fisher et al., 2012) dorsal head epidermis anlage in statu nascendi   (Fisher et al., 2012) organism | gap expression pattern   (Fisher et al., 2012) organism | faint & ubiquitous   (Fisher et al., 2012) ventral ectoderm anlage   (Fisher et al., 2012) Comment:anlage in statu nascendi embryonic stage 7 -- 8   clypeo-labral anlage   (Fisher et al., 2012) hypopharynx anlage   (Fisher et al., 2012) lateral head epidermis   (Fisher et al., 2012) ventral ectoderm   (Fisher et al., 2012) embryonic stage 9 -- 10   antennal primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium central brain primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium visual primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium dorsal head epidermis primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium lateral head epidermis primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium ventral head epidermis primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium clypeo-labral primordium   (Fisher et al., 2012) ventral ectoderm   (Fisher et al., 2012) ventral epidermis primordium   (Fisher et al., 2012) embryonic stage 11 -- 12   clypeo-labral primordium   (Fisher et al., 2012) dorsal epidermis primordium   (Fisher et al., 2012) dorsal head epidermis primordium   (Fisher et al., 2012) Comment:reported as head epidermis primordium lateral head epidermis primordium   (Fisher et al., 2012) Comment:reported as head epidermis primordium ventral head epidermis primordium   (Fisher et al., 2012) Comment:reported as head epidermis primordium epipharynx primordium   (Fisher et al., 2012) foregut primordium   (Fisher et al., 2012) hindgut proper primordium   (Fisher et al., 2012) embryonic stage 13 -- 16   embryonic epipharynx   (Fisher et al., 2012) embryonic head epidermis   (Fisher et al., 2012) embryonic head sensory system   (Fisher et al., 2012) embryonic hypopharynx   (Fisher et al., 2012)
Additional Descriptive Data
	Meltrin is expressed in broad lateral stripes in the presumptive neurogenic ectoderm. (Stathopoulos et al., 2002) Meltrin is expressed in lateral stripes in the presumptive neurogenic ectoderm. (Stathopoulos et al., 2002)
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    17 central nervous system, larvae L3    13 central nervous system, pupae P8    33 head, virgin 1-day female    11 head, virgin 4-day female    8 head, virgin 20-day female    7 head, mated 1-day female    9 head, mated 4-day female    7 head, mated 20-day female    6 head, mated 1-day male    15 head, mated 4-day male    12 head, mated 20-day male    11 salivary gland, larvae L3 wandering    8 salivary gland, white prepupae    54 digestive system, larvae L3 wandering    11 digestive system, 1-day adult    5 digestive system, 4-day adult    6 digestive system, 20-day adult    9 fat body, larvae L3 wandering    3 fat body, white prepupae    17 fat body, pupae P8    18 carcass, larvae L3 wandering    14 carcass, 1-day adult    7 carcass, 4-day adult    4 carcass, 20-day adult    5 ovary, virgin 4-day female    18 ovary, mated 4-day female    15 testis, mated 4-day male    6 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    17 central nervous system, larvae L3    13 central nervous system, pupae P8  (33) head, virgin 1-day female    11 head, virgin 4-day female    8 head, virgin 20-day female    7 head, mated 1-day female    9 head, mated 4-day female    7 head, mated 20-day female    6 head, mated 1-day male    15 head, mated 4-day male    12 head, mated 20-day male    11 salivary gland, larvae L3 wandering    8 salivary gland, white prepupae  (54) digestive system, larvae L3 wandering    11 digestive system, 1-day adult    5 digestive system, 4-day adult    6 digestive system, 20-day adult    9 fat body, larvae L3 wandering    3 fat body, white prepupae    17 fat body, pupae P8    18 carcass, larvae L3 wandering    14 carcass, 1-day adult    7 carcass, 4-day adult    4 carcass, 20-day adult    5 ovary, virgin 4-day female    18 ovary, mated 4-day female    15 testis, mated 4-day male    6 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    17 central nervous system, larvae L3    13 central nervous system, pupae P8    33 head, virgin 1-day female    11 head, virgin 4-day female    8 head, virgin 20-day female    7 head, mated 1-day female    9 head, mated 4-day female    7 head, mated 20-day female    6 head, mated 1-day male    15 head, mated 4-day male    12 head, mated 20-day male    11 salivary gland, larvae L3 wandering    8 salivary gland, white prepupae    54 digestive system, larvae L3 wandering    11 digestive system, 1-day adult    5 digestive system, 4-day adult    6 digestive system, 20-day adult    9 fat body, larvae L3 wandering    3 fat body, white prepupae    17 fat body, pupae P8    18 carcass, larvae L3 wandering    14 carcass, 1-day adult    7 carcass, 4-day adult    4 carcass, 20-day adult    5 ovary, virgin 4-day female    18 ovary, mated 4-day female    15 testis, mated 4-day male    6 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    17 central nervous system, larvae L3    13 central nervous system, pupae P8    33 head, virgin 1-day female    11 head, virgin 4-day female    8 head, virgin 20-day female    7 head, mated 1-day female    9 head, mated 4-day female    7 head, mated 20-day female    6 head, mated 1-day male    15 head, mated 4-day male    12 head, mated 20-day male    11 salivary gland, larvae L3 wandering    8 salivary gland, white prepupae    54 digestive system, larvae L3 wandering    11 digestive system, 1-day adult    5 digestive system, 4-day adult    6 digestive system, 20-day adult    9 fat body, larvae L3 wandering    3 fat body, white prepupae    17 fat body, pupae P8    18 carcass, larvae L3 wandering    14 carcass, 1-day adult    7 carcass, 4-day adult    4 carcass, 20-day adult    5 ovary, virgin 4-day female    18 ovary, mated 4-day female    15 testis, mated 4-day male    6 accessory gland, mated 4-day male    2 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    17 central nervous system, larvae L3    13 central nervous system, pupae P8    33 head, virgin 1-day female    11 head, virgin 4-day female    8 head, virgin 20-day female    7 head, mated 1-day female    9 head, mated 4-day female    7 head, mated 20-day female    6 head, mated 1-day male    15 head, mated 4-day male    12 head, mated 20-day male    11 salivary gland, larvae L3 wandering    8 salivary gland, white prepupae    54 digestive system, larvae L3 wandering    11 digestive system, 1-day adult    5 digestive system, 4-day adult    6 digestive system, 20-day adult    9 fat body, larvae L3 wandering    3 fat body, white prepupae    17 fat body, pupae P8    18 carcass, larvae L3 wandering    14 carcass, 1-day adult    7 carcass, 4-day adult    4 carcass, 20-day adult    5 ovary, virgin 4-day female    18 ovary, mated 4-day female    15 testis, mated 4-day male    6 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    17 central nervous system, larvae L3    13 central nervous system, pupae P8  (33) head, virgin 1-day female    11 head, virgin 4-day female    8 head, virgin 20-day female    7 head, mated 1-day female    9 head, mated 4-day female    7 head, mated 20-day female    6 head, mated 1-day male    15 head, mated 4-day male    12 head, mated 20-day male    11 salivary gland, larvae L3 wandering    8 salivary gland, white prepupae  (54) digestive system, larvae L3 wandering    11 digestive system, 1-day adult    5 digestive system, 4-day adult    6 digestive system, 20-day adult    9 fat body, larvae L3 wandering    3 fat body, white prepupae    17 fat body, pupae P8    18 carcass, larvae L3 wandering    14 carcass, 1-day adult    7 carcass, 4-day adult    4 carcass, 20-day adult    5 ovary, virgin 4-day female    18 ovary, mated 4-day female    15 testis, mated 4-day male    6 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    17 central nervous system, larvae L3    13 central nervous system, pupae P8    33 head, virgin 1-day female    11 head, virgin 4-day female    8 head, virgin 20-day female    7 head, mated 1-day female    9 head, mated 4-day female    7 head, mated 20-day female    6 head, mated 1-day male    15 head, mated 4-day male    12 head, mated 20-day male    11 salivary gland, larvae L3 wandering    8 salivary gland, white prepupae    54 digestive system, larvae L3 wandering    11 digestive system, 1-day adult    5 digestive system, 4-day adult    6 digestive system, 20-day adult    9 fat body, larvae L3 wandering    3 fat body, white prepupae    17 fat body, pupae P8    18 carcass, larvae L3 wandering    14 carcass, 1-day adult    7 carcass, 4-day adult    4 carcass, 20-day adult    5 ovary, virgin 4-day female    18 ovary, mated 4-day female    15 testis, mated 4-day male    6 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    17 central nervous system, larvae L3    13 central nervous system, pupae P8    33 head, virgin 1-day female    11 head, virgin 4-day female    8 head, virgin 20-day female    7 head, mated 1-day female    9 head, mated 4-day female    7 head, mated 20-day female    6 head, mated 1-day male    15 head, mated 4-day male    12 head, mated 20-day male    11 salivary gland, larvae L3 wandering    8 salivary gland, white prepupae    54 digestive system, larvae L3 wandering    11 digestive system, 1-day adult    5 digestive system, 4-day adult    6 digestive system, 20-day adult    9 fat body, larvae L3 wandering    3 fat body, white prepupae    17 fat body, pupae P8    18 carcass, larvae L3 wandering    14 carcass, 1-day adult    7 carcass, 4-day adult    4 carcass, 20-day adult    5 ovary, virgin 4-day female    18 ovary, mated 4-day female    15 testis, mated 4-day male    6 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    18 embryo 02-04hr    12 embryo 04-06hr    21 embryo 06-08hr    14 embryo 08-10hr    19 embryo 10-12hr    17 embryo 12-14hr    21 embryo 14-16hr    22 embryo 16-18hr    17 embryo 18-20hr    17 embryo 20-22hr    8 embryo 22-24hr    9 larva L1    7 larva L2    7 larva L3 12hr old    7 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    11 larva L3 puffstage 7-9    17 white prepupae new    37 white prepupae 12hr    43 white prepupae 24hr    40 pupae 2d postWPP    46 pupae 3d postWPP    16 pupae 4d postWPP    12 adult male 01day    14 adult male 05day    8 adult male 30day    8 adult female 01day    16 adult female 05day    15 adult female 30day    16 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    18 embryo 02-04hr    12 embryo 04-06hr    21 embryo 06-08hr    14 embryo 08-10hr    19 embryo 10-12hr    17 embryo 12-14hr    21 embryo 14-16hr    22 embryo 16-18hr    17 embryo 18-20hr    17 embryo 20-22hr    8 embryo 22-24hr    9 larva L1    7 larva L2    7 larva L3 12hr old    7 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    11 larva L3 puffstage 7-9    17 white prepupae new  (37) white prepupae 12hr  (43) white prepupae 24hr  (40) pupae 2d postWPP  (46) pupae 3d postWPP    16 pupae 4d postWPP    12 adult male 01day    14 adult male 05day    8 adult male 30day    8 adult female 01day    16 adult female 05day    15 adult female 30day    16 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    18 embryo 02-04hr    12 embryo 04-06hr    21 embryo 06-08hr    14 embryo 08-10hr    19 embryo 10-12hr    17 embryo 12-14hr    21 embryo 14-16hr    22 embryo 16-18hr    17 embryo 18-20hr    17 embryo 20-22hr    8 embryo 22-24hr    9 larva L1    7 larva L2    7 larva L3 12hr old    7 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    11 larva L3 puffstage 7-9    17 white prepupae new    37 white prepupae 12hr    43 white prepupae 24hr    40 pupae 2d postWPP    46 pupae 3d postWPP    16 pupae 4d postWPP    12 adult male 01day    14 adult male 05day    8 adult male 30day    8 adult female 01day    16 adult female 05day    15 adult female 30day    16 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    18 embryo 02-04hr    12 embryo 04-06hr    21 embryo 06-08hr    14 embryo 08-10hr    19 embryo 10-12hr    17 embryo 12-14hr    21 embryo 14-16hr    22 embryo 16-18hr    17 embryo 18-20hr    17 embryo 20-22hr    8 embryo 22-24hr    9 larva L1    7 larva L2    7 larva L3 12hr old    7 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    11 larva L3 puffstage 7-9    17 white prepupae new    37 white prepupae 12hr    43 white prepupae 24hr    40 pupae 2d postWPP    46 pupae 3d postWPP    16 pupae 4d postWPP    12 adult male 01day    14 adult male 05day    8 adult male 30day    8 adult female 01day    16 adult female 05day    15 adult female 30day    16 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    18 embryo 02-04hr    12 embryo 04-06hr    21 embryo 06-08hr    14 embryo 08-10hr    19 embryo 10-12hr    17 embryo 12-14hr    21 embryo 14-16hr    22 embryo 16-18hr    17 embryo 18-20hr    17 embryo 20-22hr    8 embryo 22-24hr    9 larva L1    7 larva L2    7 larva L3 12hr old    7 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    11 larva L3 puffstage 7-9    17 white prepupae new    37 white prepupae 12hr    43 white prepupae 24hr    40 pupae 2d postWPP    46 pupae 3d postWPP    16 pupae 4d postWPP    12 adult male 01day    14 adult male 05day    8 adult male 30day    8 adult female 01day    16 adult female 05day    15 adult female 30day    16 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    18 embryo 02-04hr    12 embryo 04-06hr    21 embryo 06-08hr    14 embryo 08-10hr    19 embryo 10-12hr    17 embryo 12-14hr    21 embryo 14-16hr    22 embryo 16-18hr    17 embryo 18-20hr    17 embryo 20-22hr    8 embryo 22-24hr    9 larva L1    7 larva L2    7 larva L3 12hr old    7 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    11 larva L3 puffstage 7-9    17 white prepupae new  (37) white prepupae 12hr  (43) white prepupae 24hr  (40) pupae 2d postWPP  (46) pupae 3d postWPP    16 pupae 4d postWPP    12 adult male 01day    14 adult male 05day    8 adult male 30day    8 adult female 01day    16 adult female 05day    15 adult female 30day    16 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    18 embryo 02-04hr    12 embryo 04-06hr    21 embryo 06-08hr    14 embryo 08-10hr    19 embryo 10-12hr    17 embryo 12-14hr    21 embryo 14-16hr    22 embryo 16-18hr    17 embryo 18-20hr    17 embryo 20-22hr    8 embryo 22-24hr    9 larva L1    7 larva L2    7 larva L3 12hr old    7 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    11 larva L3 puffstage 7-9    17 white prepupae new    37 white prepupae 12hr    43 white prepupae 24hr    40 pupae 2d postWPP    46 pupae 3d postWPP    16 pupae 4d postWPP    12 adult male 01day    14 adult male 05day    8 adult male 30day    8 adult female 01day    16 adult female 05day    15 adult female 30day    16 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    18 embryo 02-04hr    12 embryo 04-06hr    21 embryo 06-08hr    14 embryo 08-10hr    19 embryo 10-12hr    17 embryo 12-14hr    21 embryo 14-16hr    22 embryo 16-18hr    17 embryo 18-20hr    17 embryo 20-22hr    8 embryo 22-24hr    9 larva L1    7 larva L2    7 larva L3 12hr old    7 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    11 larva L3 puffstage 7-9    17 white prepupae new    37 white prepupae 12hr    43 white prepupae 24hr    40 pupae 2d postWPP    46 pupae 3d postWPP    16 pupae 4d postWPP    12 adult male 01day    14 adult male 05day    8 adult male 30day    8 adult female 01day    16 adult female 05day    15 adult female 30day    16 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    175 Schneider line 2 Sg4    60 embryonic 1182-4H    37 embryonic GM2    28 embryonic Kc167    18 embryonic S1    26 embryonic S3    11 leg disc CME L1    143 wing disc CME-W2    29 wing disc ML-DmD8    20 wing disc ML-DmD9    61 wing disc ML-DmD16-c3    96 wing disc ML-DmD21    25 wing disc ML-DmD32    220 haltere disc ML-DmD17-c3    22 eye-antennal disc ML-DmD11    29 antennal disc ML-DmD20-c5    51 mixed discs ML-DmD4-c1    58 CNS ML-DmBG1-c1    19 CNS ML-DmBG2-c2    13 tumorous blood cells mbn2    189 ovary fGS/OSS    9 ovary OSC    10 ovary OSS    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (175) Schneider line 2 Sg4  (60) embryonic 1182-4H  (37) embryonic GM2  (28) embryonic Kc167    18 embryonic S1  26 embryonic S3    11 leg disc CME L1  (143) wing disc CME-W2  (29) wing disc ML-DmD8    20 wing disc ML-DmD9  (61) wing disc ML-DmD16-c3  (96) wing disc ML-DmD21    25 wing disc ML-DmD32  (220) haltere disc ML-DmD17-c3    22 eye-antennal disc ML-DmD11  (29) antennal disc ML-DmD20-c5  (51) mixed discs ML-DmD4-c1  (58) CNS ML-DmBG1-c1    19 CNS ML-DmBG2-c2    13 tumorous blood cells mbn2  (189) ovary fGS/OSS    9 ovary OSC    10 ovary OSS    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+  (175) Schneider line 2 Sg4    60 embryonic 1182-4H    37 embryonic GM2    28 embryonic Kc167    18 embryonic S1    26 embryonic S3    11 leg disc CME L1  (143) wing disc CME-W2    29 wing disc ML-DmD8    20 wing disc ML-DmD9    61 wing disc ML-DmD16-c3    96 wing disc ML-DmD21    25 wing disc ML-DmD32  (220) haltere disc ML-DmD17-c3    22 eye-antennal disc ML-DmD11    29 antennal disc ML-DmD20-c5    51 mixed discs ML-DmD4-c1    58 CNS ML-DmBG1-c1    19 CNS ML-DmBG2-c2    13 tumorous blood cells mbn2  (189) ovary fGS/OSS    9 ovary OSC    10 ovary OSS    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    175 Schneider line 2 Sg4    60 embryonic 1182-4H    37 embryonic GM2    28 embryonic Kc167    18 embryonic S1    26 embryonic S3    11 leg disc CME L1    143 wing disc CME-W2    29 wing disc ML-DmD8    20 wing disc ML-DmD9    61 wing disc ML-DmD16-c3    96 wing disc ML-DmD21    25 wing disc ML-DmD32    220 haltere disc ML-DmD17-c3    22 eye-antennal disc ML-DmD11    29 antennal disc ML-DmD20-c5    51 mixed discs ML-DmD4-c1    58 CNS ML-DmBG1-c1    19 CNS ML-DmBG2-c2    13 tumorous blood cells mbn2    189 ovary fGS/OSS    9 ovary OSC    10 ovary OSS    5 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    175 Schneider line 2 Sg4    60 embryonic 1182-4H    37 embryonic GM2    28 embryonic Kc167    18 embryonic S1    26 embryonic S3    11 leg disc CME L1    143 wing disc CME-W2    29 wing disc ML-DmD8    20 wing disc ML-DmD9    61 wing disc ML-DmD16-c3    96 wing disc ML-DmD21    25 wing disc ML-DmD32    220 haltere disc ML-DmD17-c3    22 eye-antennal disc ML-DmD11    29 antennal disc ML-DmD20-c5    51 mixed discs ML-DmD4-c1    58 CNS ML-DmBG1-c1    19 CNS ML-DmBG2-c2    13 tumorous blood cells mbn2    189 ovary fGS/OSS    9 ovary OSC    10 ovary OSS    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (175) Schneider line 2 Sg4  (60) embryonic 1182-4H  (37) embryonic GM2  28 embryonic Kc167    18 embryonic S1  26 embryonic S3    11 leg disc CME L1  (143) wing disc CME-W2  29 wing disc ML-DmD8    20 wing disc ML-DmD9  (61) wing disc ML-DmD16-c3  (96) wing disc ML-DmD21    25 wing disc ML-DmD32  (220) haltere disc ML-DmD17-c3    22 eye-antennal disc ML-DmD11  29 antennal disc ML-DmD20-c5  (51) mixed discs ML-DmD4-c1  (58) CNS ML-DmBG1-c1    19 CNS ML-DmBG2-c2    13 tumorous blood cells mbn2  (189) ovary fGS/OSS    9 ovary OSC    10 ovary OSS    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+  (175) Schneider line 2 Sg4    60 embryonic 1182-4H    37 embryonic GM2    28 embryonic Kc167    18 embryonic S1    26 embryonic S3    11 leg disc CME L1  143 wing disc CME-W2    29 wing disc ML-DmD8    20 wing disc ML-DmD9    61 wing disc ML-DmD16-c3    96 wing disc ML-DmD21    25 wing disc ML-DmD32  (220) haltere disc ML-DmD17-c3    22 eye-antennal disc ML-DmD11    29 antennal disc ML-DmD20-c5    51 mixed discs ML-DmD4-c1    58 CNS ML-DmBG1-c1    19 CNS ML-DmBG2-c2    13 tumorous blood cells mbn2  (189) ovary fGS/OSS    9 ovary OSC    10 ovary OSS    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    175 Schneider line 2 Sg4    60 embryonic 1182-4H    37 embryonic GM2    28 embryonic Kc167    18 embryonic S1    26 embryonic S3    11 leg disc CME L1    143 wing disc CME-W2    29 wing disc ML-DmD8    20 wing disc ML-DmD9    61 wing disc ML-DmD16-c3    96 wing disc ML-DmD21    25 wing disc ML-DmD32    220 haltere disc ML-DmD17-c3    22 eye-antennal disc ML-DmD11    29 antennal disc ML-DmD20-c5    51 mixed discs ML-DmD4-c1    58 CNS ML-DmBG1-c1    19 CNS ML-DmBG2-c2    13 tumorous blood cells mbn2    189 ovary fGS/OSS    9 ovary OSC    10 ovary OSS    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    11 cold shock, 4-day adult    8 heat shock, 4-day adult    8 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    5 Cadmium 50 mM 48 hrs, 4-day adult    10 Cadmium 100 mM 48 hrs, 4-day adult    13 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    7 Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3    15 Ethanol 5% 3 hrs, larvae L3    6 Ethanol 10% 3 hrs, larvae L3    5 Caffeine 1.5 mg/ml 4 hrs, larvae L3    5 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    11 Caffeine 25 mg/ml 48 hrs, 4-day adult    9 Paraquat 5 mM 48 hrs, 4-day adult    11 Paraquat 10 mM 48 hrs, 4-day adult    15 Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    4 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    11 cold shock, 4-day adult    8 heat shock, 4-day adult    8 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    5 Cadmium 50 mM 48 hrs, 4-day adult    10 Cadmium 100 mM 48 hrs, 4-day adult    13 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    7 Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3    15 Ethanol 5% 3 hrs, larvae L3    6 Ethanol 10% 3 hrs, larvae L3    5 Caffeine 1.5 mg/ml 4 hrs, larvae L3    5 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    11 Caffeine 25 mg/ml 48 hrs, 4-day adult    9 Paraquat 5 mM 48 hrs, 4-day adult    11 Paraquat 10 mM 48 hrs, 4-day adult    15 Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    11 cold shock, 4-day adult    8 heat shock, 4-day adult    8 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    5 Cadmium 50 mM 48 hrs, 4-day adult    10 Cadmium 100 mM 48 hrs, 4-day adult    13 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    7 Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3    15 Ethanol 5% 3 hrs, larvae L3    6 Ethanol 10% 3 hrs, larvae L3    5 Caffeine 1.5 mg/ml 4 hrs, larvae L3    5 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    11 Caffeine 25 mg/ml 48 hrs, 4-day adult    9 Paraquat 5 mM 48 hrs, 4-day adult    11 Paraquat 10 mM 48 hrs, 4-day adult    15 Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    11 cold shock, 4-day adult    8 heat shock, 4-day adult    8 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    5 Cadmium 50 mM 48 hrs, 4-day adult    10 Cadmium 100 mM 48 hrs, 4-day adult    13 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    7 Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3    15 Ethanol 5% 3 hrs, larvae L3    6 Ethanol 10% 3 hrs, larvae L3    5 Caffeine 1.5 mg/ml 4 hrs, larvae L3    5 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    11 Caffeine 25 mg/ml 48 hrs, 4-day adult    9 Paraquat 5 mM 48 hrs, 4-day adult    11 Paraquat 10 mM 48 hrs, 4-day adult    15 Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    4 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    11 cold shock, 4-day adult    8 heat shock, 4-day adult    8 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    5 Cadmium 50 mM 48 hrs, 4-day adult    10 Cadmium 100 mM 48 hrs, 4-day adult    13 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    7 Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3    15 Ethanol 5% 3 hrs, larvae L3    6 Ethanol 10% 3 hrs, larvae L3    5 Caffeine 1.5 mg/ml 4 hrs, larvae L3    5 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    11 Caffeine 25 mg/ml 48 hrs, 4-day adult    9 Paraquat 5 mM 48 hrs, 4-day adult    11 Paraquat 10 mM 48 hrs, 4-day adult    15 Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    4 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    11 cold shock, 4-day adult    8 heat shock, 4-day adult    8 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    5 Cadmium 50 mM 48 hrs, 4-day adult    10 Cadmium 100 mM 48 hrs, 4-day adult    13 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    7 Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3    15 Ethanol 5% 3 hrs, larvae L3    6 Ethanol 10% 3 hrs, larvae L3    5 Caffeine 1.5 mg/ml 4 hrs, larvae L3    5 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    11 Caffeine 25 mg/ml 48 hrs, 4-day adult    9 Paraquat 5 mM 48 hrs, 4-day adult    11 Paraquat 10 mM 48 hrs, 4-day adult    15 Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    11 cold shock, 4-day adult    8 heat shock, 4-day adult    8 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    5 Cadmium 50 mM 48 hrs, 4-day adult    10 Cadmium 100 mM 48 hrs, 4-day adult    13 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    7 Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3    15 Ethanol 5% 3 hrs, larvae L3    6 Ethanol 10% 3 hrs, larvae L3    5 Caffeine 1.5 mg/ml 4 hrs, larvae L3    5 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    11 Caffeine 25 mg/ml 48 hrs, 4-day adult    9 Paraquat 5 mM 48 hrs, 4-day adult    11 Paraquat 10 mM 48 hrs, 4-day adult    15 Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    11 cold shock, 4-day adult    8 heat shock, 4-day adult    8 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    5 Cadmium 50 mM 48 hrs, 4-day adult    10 Cadmium 100 mM 48 hrs, 4-day adult    13 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    7 Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3    15 Ethanol 5% 3 hrs, larvae L3    6 Ethanol 10% 3 hrs, larvae L3    5 Caffeine 1.5 mg/ml 4 hrs, larvae L3    5 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    11 Caffeine 25 mg/ml 48 hrs, 4-day adult    9 Paraquat 5 mM 48 hrs, 4-day adult    11 Paraquat 10 mM 48 hrs, 4-day adult    15 Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_27 mE1_20_mRNA_expression_cluster_09
External Data & Images
Linkouts	BDGP expression data • RE23052
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal MeltrinCB02076 viable, with Scer\GAL4pnr-MD237 MeltrinGD124 MeltrinGD2620 MeltrinGD2984 MeltrinGD14454 Other Phenotypes Allele wild-type, with Scer\GAL4Bx-MS1096 MeltrindsRNA.Scer\UAS Phenotype manifest in Allele
Classical Alleles ( 22 )
For All Classical Alleles Show
Allele of Meltrin Class Mutagen Stocks Known lesion Meltrinc01955 piggyBac transposase 2 -- Meltrinc768 P-element activity 2 -- Meltrin5-HA-1250 1 -- Meltrin5-SZ-3481 1 -- Meltrin5-SZ-3507 1 -- Meltrinc02370 1 -- Meltrine00310 1 -- Meltrine00483 1 -- MeltrinEY00279 1 -- MeltrinEY03366 1 -- Meltrinf04523 1 -- MeltrinMB01428 1 -- MeltrinMI00791 1 -- MeltrinNP1317 1 -- MeltrinNP2311 1 -- Meltrinc02171 0 -- Meltrinc02186 0 -- MeltrinCB02076 P-element activity 0 Yes MeltrinCPTI000218 piggyBac transposase 0 Yes MeltrinCPTI001259 piggyBac transposase 0 Yes MeltrinEP3074 0 -- MeltrinEP3514 0 --
Alleles Carried on Transgenic Constructs ( 7 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Meltrin Class Mutagen Stocks Known lesion MeltrinGD124 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes MeltrinGD14454 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes MeltrinGD2620 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes MeltrinGD2984 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes MeltrinKK110487 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes MeltrindsRNA.Scer\UAS in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes MeltrinScer\UAS.T:Ivir\HA1 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3R)Exel8160 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}MeltrinEP3074 NA P{EP}MeltrinEP3514 NA P{EPgy2}MeltrinEY00279 NA P{EPgy2}MeltrinEY03366 NA miscellaneous insertions Mi{MIC}MeltrinMI00791 NA P{PTT-GB}MeltrinCB02076 NA P{RS5}Meltrin5-HA-1250 NA P{RS5}Meltrin5-SZ-3481 NA P{RS5}Meltrin5-SZ-3507 NA P{wHy}DG23403 NA PBac{602.P.SVS-1}MeltrinCPTI000218 NA PBac{681.P.FSVS-1}MeltrinCPTI001259 NA PBac{PB}Meltrinc01955 NA PBac{PB}Meltrinc02171 NA PBac{PB}Meltrinc02186 NA PBac{PB}Meltrinc02370 NA PBac{RB}Meltrine00310 NA PBac{RB}Meltrine00483 NA PBac{WH}Meltrinf04523 NA insertion of enhancer trap binary system Mi{ET1}MeltrinMB01428 No P{GawB}Meltrinc768 No P{GawB}MeltrinNP1317 No P{GawB}MeltrinNP2311 No
Gene Ontology: Function, Process & Cellular Component ( 6 unique terms )
Terms Based on Experimental Evidence ( 4 terms )
Molecular Function
CV term Evidence References
identical protein binding inferred from physical interaction with Meltrin (Meyer et al., 2010) metalloendopeptidase activity inferred from direct assay (Sapir et al., 2005)
Biological Process
CV term Evidence References
membrane protein ectodomain proteolysis inferred from direct assay (Sapir et al., 2005) protein oligomerization inferred from direct assay (Meyer et al., 2010)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 3 terms )
Molecular Function
CV term Evidence References
zinc ion binding inferred from electronic annotation with InterPro:IPR002870 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
membrane protein ectodomain proteolysis inferred from sequence or structural similarity with human ADAM17 (Curators, 2008--)
Cellular Component
CV term Evidence References
integral to membrane inferred from sequence or structural similarity with human ADAM17 (Curators, 2008--)
Sequence Ontology: Class of Gene
	gene   nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Meltrin allele Gene References
External Data
Linkouts
Orthologs
OrthoDB Orthologs (39) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG66HGW4 Dipteran inclusive ortholog search EOG6P2Q9B Insect inclusive ortholog search EOG61NSG0 Arthropod inclusive ortholog search EOG6BZKHH Metazoa inclusive ortholog search EOG6BS8CG
Orthologs in Drosophila Species (EOG66HGW4)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Meltrin     Drosophila simulans   Dsim\GD20406 Y   Drosophila sechellia   Dsec\GM25832     Drosophila erecta   Dere\GG21132 Y   Drosophila yakuba   Dyak\GE26433 Y   Drosophila ananassae   Dana\GF17538 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA27151 Y   Drosophila persimilis   Dper\GL23123 Y   Drosophila willistoni   Dwil\GK14446 Y   Drosophila virilis   Dvir\GJ22896 Y   Drosophila mojavensis   Dmoj\GI22077 Y   Drosophila grimshawi   Dgri\GH18929 Y   Drosophila grimshawi   Dgri\GH18930
Orthologs in non-Drosophila Dipterans (EOG6P2Q9B)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Anopheles gambiae Malaria mosquito  Agam\AGAP003498   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ012681
Orthologs in non-Dipteran Insects (EOG61NSG0)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB50185   Apis mellifera Western honey bee  Amel\GB50184   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG019658   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG019651   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH20524   Atta cephalotes Leafcutter ant  Acep\ACEP22853   Atta cephalotes Leafcutter ant  Acep\ACEP22856   Camponotus floridanus Florida carpenter ant  Cflo\CFLO14394   Camponotus floridanus Florida carpenter ant  Cflo\CFLO14393   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL13766   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL13767   Linepithema humile Argentine ant  Lhum\LH18272   Linepithema humile Argentine ant  Lhum\LH18275   Pogonomyrmex barbatus Red harvester ant  Pbar\PB25388   Pogonomyrmex barbatus Red harvester ant  Pbar\PB25386   Solenopsis invicta Red fire ant  Sinv\SINV12815   Solenopsis invicta Red fire ant  Sinv\SINV12816   Acyrthosiphon pisum Pea aphid  Apim\ACYPI007727   Bombyx mori Silkmoth  Bmor\BGIBMGA010830   Pediculus humanus Human body louse  Phum\PHUM252150   Tribolium castaneum Red flour beetle  Tcas\TC010657
Orthologs in non-Insect Arthropods (EOG6BZKHH)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\JGI_V11_56831   Ixodes scapularis Deer tick  Isca\ISCW001423
Orthologs in non-Arthropod Metazoa (EOG6BS8CG)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\adm-2
Human Orthologs (0)
Gene OMIM HGNC
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD20406 Drosophila sechellia Dsec\GM25835 Drosophila erecta Dere\GG21132 Drosophila yakuba Dyak\GE26433 Drosophila ananassae Dana\GF17538 Drosophila pseudoobscura pseudoobscura Dpse\GA27151 Drosophila persimilis Dper\GL23123 Drosophila willistoni Dwil\GK14446 Drosophila virilis Dvir\GJ22896 Drosophila mojavensis Dmoj\GI22077 Drosophila grimshawi Dgri\GH18929
Stocks & Reagents
Stocks Listed in FlyBase ( 26 )
Harvard	- PBac{PB}Meltrinc01955 - PBac{PB}Meltrinc02370 - PBac{RB}Meltrine00310 - PBac{RB}Meltrine00483 - PBac{WH}Meltrinf04523
VDRC	v102041 P{KK110487}VIE-260B v3702 w1118; P{GD124}v3702 v8394 w1118; P{GD2620}v8394 v8395 w1118; P{GD2620}v8395 v44407 w1118; P{GD2984}v44407 v27177 w1118; P{GD14454}v27177 v27178 w1118; P{GD14454}v27178
	More stocks available...
Genomic Clones ( 2 )
	BACR18C01 BACR45M03 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 82 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	RE23052 RH30043 SD03917 SD04095
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GM07470 LD34743 LP07167 RE08053 RE56634 RH30042 RH31527 RH35352 RH65120 SD03465 SD04085 SD04573 SD09717 SD10754 SD15865 SD16969 SD18036 SD21381 SD22443 SD23164 SD27008
Other clones	42407 44081 65693 101056 107969 163061 165475 214217.37 214409.41 524395 533612 542603 bs67g04 CK01.101D.G6 EK003113 EK006801 EK029209 EK085859 EK126102 EK157164 EK160252 EK223661 EK234154 EK269822 EN05318 EN09848 EN10939 EP12728 EP18328 FGM001H09 FGM003A11 GH14307 RC0-DA0008-130700-011-C06 RP003034703 RP003052907 RP003085404 RP003086428 RP003089202 RP003101305 RP003116274 RP003116710 RP003188421 RP003193978 RP003206681 RP003217788 RP003244910 RP003251586 RP003275114 RP003279114 RP003302562 RP003347517 RP003506140 RP003510597 RP003534989 RP003631481 RP003644038 RP003644790
RNAi & Array Information
Linkouts
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Meltrin Neu3 (Sapir et al., 2005)
Source for database merge of	Source for merge of: CG31314 CG31385 (Sapir, 2004.1.14) Source for merge of: Neu3 Meltrin-α (Sapir et al., 2005)
Additional comments	Annotations CG31314 and CG31385 merged as CG7649 (which corresponds to Neu3) in release 4.2 of the genome annotation. (FlyBase Genome Annotators, 2005) Annotation CG7649 split into CG31314 and CG31385 in release 3 of the genome annotation. (FlyBase Genome Annotators, 2002-2003)
Other Comments
	Mutations cause recessive embryonic lethality. Larval wing and eye imaginal disc clones homozygous for the mutation failed to develop. (Sapir and Shilo, 2002)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_001032403 NM_001032404 RefSeq (Proteins) • NP_001027575 NP_001027576 DDBJ / EMBL / GenBank • AAF55088.2 AAM11424 AAN13615.1 AAO39439 AAS48651 AAZ83995 AAZ83996 AI532409 AI532555 AW944333 AY095096 AY525769 BG639663 BI216127 BT003436 CZ467576 Entrez Gene - A searchable database of RefSeq genes. • 3772109 UniProtKB/TrEMBL • Q6QU65 Q8T3I9 Q86P79 Q400M8
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Epidermal growth factor-like domain (IPR000742) Peptidase M12B, ADAM/reprolysin (IPR001590) Blood coagulation inhibitor, Disintegrin (IPR001762) Peptidase M12B, propeptide (IPR002870) ADAM, cysteine-rich (IPR006586) EGF-like, conserved site (IPR013032) Metallopeptidase, catalytic domain (IPR024079) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • RE23052
Linkouts
Synonyms & Secondary IDs ( 13 )
Reported As
Symbol Synonym	CG7649 (Asha et al., 2003, Stathopoulos et al., 2002, Keleman et al., 2009.8.5, Yu et al., 2010, Meyer et al., 2010) CG31314   CG31385   CT23341 (Hynes and Zhao, 2000, Hynes and Zhao, 2000) Dmelt (Sapir et al., 2005) DMeltrin (Sapir et al., 2005) Meltrin   meltrin (Meyer et al., 2011) Meltrin-α (Sapir et al., 2005) Neu3 (Korenjak et al., 2012, Buszczak et al., 2007, Lott et al., 2011, Firth and Baker, 2007, Liberman and Stathopoulos, 2009, Boettiger and Levine, 2009, Campos et al., 2010, Skora and Spradling, 2010, Meyer et al., 2010, Reeves et al., 2012)
Name Synonym	DMeltrin (Sapir et al., 2005) dMeltrin-alpha (Sapir and Shilo, 2002) meltrin (Meyer et al., 2010) Meltrin   Meltrin-like (Hynes and Zhao, 2000) Meltrin-α   Neu3   Neuroectoderm-expressed 3
Secondary FlyBase IDs
	FBgn0038253 FBgn0051314 FBgn0051385 FBgn0062267 FBpp0082431 FBpp0082432 FBtr0082972 FBtr0082973
References ( 45 )
Generate a list of	All references relating to this gene ( 45 )
List References by type	Research paper  ( 13 ) Supplementary material  ( 7 ) Review  ( 1 ) Personal communication to FlyBase  ( 13 ) Abstract  ( 1 ) FlyBase analysis  ( 6 ) DNA/RNA sequence record  ( 1 ) Website  ( 1 ) Curated genome annotation  ( 2 )
Recent research papers ( 3 )
	Korenjak et al., 2012, Mol. Cell. Biol. 32(21): 4375--4387 RBF Binding to both Canonical E2F Targets and Noncanonical Targets Depends on Functional dE2F/dDP Complexes. [FBrf0219643] Reeves et al., 2012, Dev. Cell 22(3): 544--557 Dorsal-ventral gene expression in the Drosophila embryo reflects the dynamics and precision of the dorsal nuclear gradient. [FBrf0217797] Lott et al., 2011, PLoS Biol. 9(2): e1000590 Noncanonical Compensation of Zygotic X Transcription in Early Drosophila melanogaster Development Revealed through Single-Embryo RNA-Seq. [FBrf0213135] Show all research papers ...
Recent reviews ( 1 )
	Meyer et al., 2011, Europ. J. Cell Biol. 90(9): 770--778 Drosophila metalloproteases in development and differentiation: The role of ADAM proteins and their relatives. [FBrf0214506] Show all reviews ...