FB2021_01, released Feb 18, 2021

Gene: Dmel\Gyg

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General Information
Symbol
Dmel\Gyg
Species
D. melanogaster
Name
Glycogenin
Annotation Symbol
CG44244
Feature Type
protein_coding_gene
FlyBase ID
FBgn0265191
Gene Model Status
Current
Stock Availability
6 publicly available
Gene Snapshot
Contributions welcome
Other Summaries
Key Links
Genomic Location
Cytogenetic map
57D1-57D1
Sequence location
2R:21,200,483..21,210,821 [+]
Recombination map

2-94

RefSeq locus
NT_033778 REGION:21200483..21210821
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (5 terms)
Molecular Function (2 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
enables glycogenin glucosyltransferase activity
inferred from sequence or structural similarity with RGD:621785
(FlyBase Curators, 2008--)
enables transferase activity, transferring glycosyl groups
inferred from biological aspect of ancestor with PANTHER:PTN004238949
(assigned by GO_Central )
(Gaudet et al., 2011)
Biological Process (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
involved_in glycogen biosynthetic process
inferred from sequence or structural similarity with RGD:621785
(FlyBase Curators, 2008--)
Cellular Component (2 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
located_in cytosol
inferred from high throughput direct assay
(Lye et al., 2014)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
located_in cytoplasm
inferred from biological aspect of ancestor with PANTHER:PTN000127027
(assigned by GO_Central )
(Gaudet et al., 2011)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Group (FlyBase)
OTHER GLUCOSYLTRANSFERASES -
The 'other glucosyltransferases' group comprises glucosyltransferases that do not fit into any of the other major groupings.
Gene Model and Products
Number of Transcripts
6
Number of Unique Polypeptides
6

Please see the JBrowse view of Dmel\Gyg for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Gene model reviewed during 5.49

Genes with CDS overlap: isoforms of Glycogenin and CG44245 share promoter, first exon and N-terminal coding sequences (28 residues); overlapping structure not conserved outside of Drosophila.

Gene model reviewed during 5.45

Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.

Low-frequency RNA-Seq exon junction(s) not annotated.

Sequence Ontology: Class of Gene
nuclear_gene
(FlyBase Genome Annotators, 2012)
protein_coding_gene
(FlyBase Genome Annotators, 2012)
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Gyg-RB
FBtr0339088
NM_166432
2378
333
Gyg-RD
FBtr0339090
NM_001259517
3014
545
Gyg-RE
FBtr0339089
NM_001299737
2504
699
Gyg-RG
FBtr0339091
NM_001299738
2447
356
Gyg-RH
FBtr0339092
NM_001299739
2010
334
Gyg-RI
FBtr0339093
NM_001169761
2404
287
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
Gyg-PB
FBpp0308233
37.8
333
5.09
NP_726040
AAF46696
Gyg-PD
FBpp0308235
61.7
545
5.38
NP_001246446
AFH08199
Gyg-PE
FBpp0308234
78.1
699
5.95
NP_001286666
AHN56461
Gyg-PG
FBpp0308236
40.1
356
4.90
NP_001286667
AHN56462
Gyg-PH
FBpp0308237
38.1
334
5.09
NP_001286668
AHN56463
Gyg-PI
FBpp0308238
32.8
287
4.62
NP_001163232
ACZ94504
Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Gyg using the Feature Mapper tool.

External Data
Crossreferences
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
day 5 of adulthood & male -- day 7 of adulthood & male
spermatozoon
(Dorus et al., 2006)
day 7 of adulthood -- day 49 of adulthood
adult heart
(Cammarato et al., 2011)
adult stage
adult head
(Aradska et al., 2015)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in cytosol
inferred from high throughput direct assay
(Lye et al., 2014)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Gyg in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 7 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 4 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Gyg
Transgenic constructs containing regulatory region of Gyg
Aberrations (Deficiencies and Duplications) ( 0 )
Inferred from experimentation
Inferred from location
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4pnr-MD237
viable, with Scer\GAL4tin.CΔ4
Other Phenotypes
Allele
flightless, with Scer\GAL4Mef2.PR
visible, with Scer\GAL4pnr-MD237
Phenotype manifest in
Allele
mesothoracic tergum, with Scer\GAL4pnr-MD237
trichogen cell, with Scer\GAL4pnr-MD237
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (2)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\GYG1
11 of 15
Yes
Yes
Hsap\GYG2
7 of 15
No
Yes
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Gyg
10 of 15
Yes
Yes
Rattus norvegicus (Norway rat) (1)
Rnor\Gyg1
10 of 13
Yes
Yes
Xenopus tropicalis (Western clawed frog) (2)
Xtro\gyg1
11 of 12
Yes
Yes
Xtro\gyg2
8 of 12
No
Yes
Danio rerio (Zebrafish) (3)
Drer\gyg1b
11 of 15
Yes
Yes
Drer\gyg1a
9 of 15
No
Yes
Drer\gyg2
7 of 15
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (4)
Cele\gyg-1
7 of 15
Yes
Yes
Cele\gyg-2
7 of 15
Yes
Yes
Cele\T10B10.8
4 of 15
No
Yes
Cele\M116.2
1 of 15
No
Yes
Arabidopsis thaliana (thale-cress) (16)
Atha\GolS1
3 of 9
Yes
Yes
Atha\GolS2
3 of 9
Yes
Yes
Atha\GolS3
3 of 9
Yes
Yes
Atha\GolS4
3 of 9
Yes
Yes
Atha\GolS5
3 of 9
Yes
Yes
Atha\GolS6
3 of 9
Yes
Yes
Atha\GolS7
3 of 9
Yes
Yes
Atha\PGSIP1
3 of 9
Yes
Yes
Atha\PGSIP2
3 of 9
Yes
Yes
Atha\PGSIP3
3 of 9
Yes
Yes
Atha\PGSIP4
3 of 9
Yes
Yes
Atha\PGSIP5
3 of 9
Yes
Yes
Atha\PGSIP6
3 of 9
Yes
Yes
Atha\GolS10
2 of 9
No
Yes
Atha\PGSIP7
2 of 9
No
Yes
Atha\PGSIP8
2 of 9
No
Yes
Saccharomyces cerevisiae (Brewer's yeast) (4)
Scer\GLG1
6 of 15
Yes
Yes
Scer\GLG2
6 of 15
Yes
Yes
Scer\GNT1
1 of 15
No
Yes
Scer\IDS2
1 of 15
No
Yes
Schizosaccharomyces pombe (Fission yeast) (3)
Spom\mug136
4 of 12
Yes
Yes
Spom\SPBC4C3.09
3 of 12
No
Yes
Spom\SPAC5H10.12c
2 of 12
No
Yes
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG091906US )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00002209
Drosophila simulans
Dsim\GD11576
Drosophila sechellia
Dsec\GM15817
Drosophila erecta
Dere\GG22100
Drosophila yakuba
Dyak\GE12180
Drosophila ananassae
Dana\GF12803
Drosophila pseudoobscura pseudoobscura
Dpse\GA21819
Drosophila persimilis
Dper\GL11328
Drosophila willistoni
Dwil\GK15794
Drosophila virilis
Dvir\GJ22086
Drosophila mojavensis
Dmoj\GI20361
Drosophila grimshawi
Dgri\GH21859
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG0915013L )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17010614
Glossina morsitans
Tsetse fly
Gmor\GMOY010934
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_11372
Mayetiola destructor
Hessian fly
Mdes\Mdes011456
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL014863
Anopheles darlingi
American malaria mosquito
Adar\ADAC004725
Anopheles gambiae
Malaria mosquito
Agam\AGAP007724
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ013596
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W064G )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA002596
Danaus plexippus
Monarch butterfly
Dple\DPOGS201438-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL015987
Apis florea
Little honeybee
Aflo\2544973508
Apis mellifera
Western honey bee
Amel\GB42652
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP25276
Bombus terrestris
Buff-tailed bumblebee
Bter\15207381
Linepithema humile
Argentine ant
Lhum\LH12590
Linepithema humile
Argentine ant
Lhum\LH12589
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:0027d9
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG003411
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_09267
Tribolium castaneum
Red flour beetle
Tcas\TC031466
Pediculus humanus
Human body louse
Phum\PHUM407280
Rhodnius prolixus
Kissing bug
Rpro\RPRC004998
Cimex lectularius
Bed bug
Clec\CLEC001980
Cimex lectularius
Bed bug
Clec\CLEC001979
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI005296
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_17739
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X05ZZ )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR006763
Ixodes scapularis
Black-legged tick
Isca\ISCW006112
Ixodes scapularis
Black-legged tick
Isca\ISCW005321
Ixodes scapularis
Black-legged tick
Isca\ISCW017044
Stegodyphus mimosarum
African social velvet spider
Smim\KFM64744.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM76725.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM73844.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur29g01640
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_213367
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G09E1 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Gyg1
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000021053
Gallus gallus
Domestic chicken
Ggal\GYG1
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000016655
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (0)
No records found.
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 1 )
    Human Ortholog
    Disease
    Evidence
    References
    GYG1; glycogenin 1
    model of  glycogen storage disease XV
    IEA
    (FlyBase, 2019-)
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    GYG1; glycogenin 1
    11 of 15
    603942
    GYG2; glycogenin 2
    7 of 15
    300198
        Functional Complementation Data
        Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
        Interactions
        Summary of Physical Interactions
        esyN Network Diagram
        Show neighbor-neighbor interactions:
        Select Layout:
        Legend:
        Protein
        RNA
        Selected Interactor(s)
        Interactions Browser
        View in Interactions Browser
        Please see the Physical Interaction reports below for full details
        protein-protein
        Physical Interaction
        Assay
        References
        Gyg - p38b
        anti tag coimmunoprecipitation, anti tag western blot, peptide massfingerprinting
        (Belozerov et al., 2012)
        Summary of Genetic Interactions
        esyN Network Diagram
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        External Data
        Linkouts
        MIST (protein-protein) - An integrated Molecular Interaction Database
        Pathways
        Signaling Pathways (FlyBase)
        Metabolic Pathways
        External Data
        Linkouts
        KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
        Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
        Genomic Location and Detailed Mapping Data
        Chromosome (arm)
        2R
        Recombination map

        2-94

        Cytogenetic map
        57D1-57D1
        Sequence location
        2R:21,200,483..21,210,821 [+]
        FlyBase Computed Cytological Location
        Cytogenetic map
        Evidence for location
        57D1-57D1
        Limits computationally determined from genome sequence between P{EP}CG4266EP2258 and P{EP}CG30394EP962&P{lacW}domk08108
        Experimentally Determined Cytological Location
        Cytogenetic map
        Notes
        References
        Experimentally Determined Recombination Data
        Location

        2-94

        (FlyBase, 2016)

        2-100.3

        (Comeron et al., 2012)
        Left of (cM)
        Right of (cM)
        Notes
        Stocks and Reagents
        Stocks (6)
        Genomic Clones (20)
        cDNA Clones (58)
         

        Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

        cDNA clones, fully sequenced
        BDGP DGC clones
        Other clones
        Drosophila Genomics Resource Center cDNA clones

        For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

        cDNA Clones, End Sequenced (ESTs)
        BDGP DGC clones
        Other clones
        RNAi and Array Information
        Linkouts
        GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
        Antibody Information
        Laboratory Generated Antibodies
         
        Commercially Available Antibodies
         
        Other Information
        Relationship to Other Genes
        Source for database identify of

        Source for identity of: Glycogenin CG9480

        (Tolmasky et al., 2001)

        Source for identity of: Gyg Glycogenin

        (FlyBase, 2009-)
        Source for database merge of

        Source for merge of: Glycogenin NEST:bs16a02

        (Rana, 2004.7.8)
        Additional comments

        Annotation CG9480 split into CG44244 (which corresponds to Glycogenin) and CG44245 in release 5.49 of the genome annotation. The two annotations share a common 5' exon which encodes 3 N-terminal amino acid residues, but otherwise encode two distinct proteins.

        (FlyBase Genome Annotators, 2012)

        The 'Glycogenin' gene previously had no abbreviated gene symbol - assigning 'Gyg' to mirror the symbol used for the vertebrate 'Glycogenin' genes.

        (FlyBase, 2009-)
        Other Comments
        Origin and Etymology
        Discoverer
        Etymology
        Identification
        External Crossreferences and Linkouts ( 44 )
        Sequence Crossreferences
        NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
        GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
        GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
        RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
        UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
        Other crossreferences
        BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
        Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
        Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
        GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
        InterPro - A database of protein families, domains and functional sites
        KEGG Genes - Molecular building blocks of life in the genomic space.
        Linkouts
        KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
        MIST (protein-protein) - An integrated Molecular Interaction Database
        Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
        Synonyms and Secondary IDs (5)
        Datasets (0)
        Study focus (0)
        Experimental Role
        Project
        Project Type
        Title
        References (47)