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Gene Dmel\CG18258

General Information
Symbol	Dmel\CG18258	Species	D. melanogaster
Name		Annotation symbol	CG18258
Feature type	protein_coding_gene	FlyBase ID	FBgn0265267
Gene Model Status	Current	Stock availability	3 publicly available
Genomic Location
Chromosome (arm)	X	Recombination map
Cytogenetic map	15F3-15F4	Sequence location	X:17,106,340..17,108,010 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	This gene is referred to in FlyBase by the symbol Dmel\CG18258 (FBgn0265267). It is a protein_coding_gene from Drosophila melanogaster. An electronic pipeline based on InterPro domains suggests that it has the molecular function: catalytic activity. An electronic pipeline based on InterPro domains suggests that it is involved in the biological process: lipid metabolic process. 2 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: Lipase; Lipase, N-terminal. Gene sequence location is X:17106361..17108010.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03	Alleles CG18258[MI07578] Controlled Vocabulary Terms cellular_component molecular_function biological_process
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 15F3-15F4   Limits computationally determined from genome sequence between P{EP}bazEP1446 and P{EP}EP1464
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\CG18258 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.51
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) CG18258-RA FBtr0074392  NM_132973   1497   468
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein CG18258-PA   FBpp0074166   51.2   468   4.94     NP_573201   AAF48708
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Lipase (IPR000734) Lipase, N-terminal (IPR013818)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014298 AAF48708   BT024983   CB305236   EL882378   EL882379   EL882614   EL882615
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VX70
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism | faint & ubiquitous   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 4 -- 6   organism   (Fisher et al., 2012) Comment:rapidly degraded
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
[an error occurred while processing this directive] FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
[an error occurred while processing this directive]
modENCODE Development RNA-Seq
[an error occurred while processing this directive] modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
[an error occurred while processing this directive]
modENCODE Treatments RNA-Seq
[an error occurred while processing this directive]
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (Graveley et al., 2011) mE1_20_mRNA_expression_cluster_20
External Data & Images
Linkouts	BDGP expression data • IP12247
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 CG18258GD9541 Phenotype manifest in Allele
Classical Alleles ( 1 )
For All Classical Alleles Show
Allele of CG18258 Class Mutagen Stocks Known lesion CG18258MI07578 1 --
Alleles Carried on Transgenic Constructs ( 2 )
For All Alleles Carried on Transgenic Constructs Show
Allele of CG18258 Class Mutagen Stocks Known lesion CG18258GD9541 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CG18258KK105335 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD9541} NA P{KK105335} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions Mi{MIC}CG18258MI07578 NA
Gene Ontology: Function, Process & Cellular Component ( 2 unique terms )
	There is no information supporting a cellular component term for this gene. (Based on a review of available data on: 2013-02-15)
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 2 terms )
Molecular Function
CV term Evidence References
catalytic activity inferred from electronic annotation with InterPro:IPR000734 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
lipid metabolic process inferred from electronic annotation with InterPro:IPR000734 (FlyBase Curators et al., 2004-)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions CG18258 allele Gene References
External Data
Linkouts
Orthologs
OrthoDB Orthologs (13) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6P2QN7 Dipteran inclusive ortholog search No orthologs identified Insect inclusive ortholog search EOG6X6B52 Arthropod inclusive ortholog search No orthologs identified Metazoa inclusive ortholog search No orthologs identified
Orthologs in Drosophila Species (EOG6P2QN7)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\CG18258     Drosophila simulans   Dsim\GD17337 Y   Drosophila sechellia   Dsec\GM13496 Y   Drosophila erecta   Dere\GG19105 Y   Drosophila yakuba   Dyak\GE17651 Y   Drosophila ananassae   Dana\GF22326 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA14858 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA28231     Drosophila persimilis   Dper\GL19877     Drosophila persimilis   Dper\GL19878 Y   Drosophila willistoni   Dwil\GK18858 Y   Drosophila virilis   Dvir\GJ14890 Y   Drosophila mojavensis   Dmoj\GI15547 Y
Orthologs in non-Drosophila Dipterans (None identified)
No non-Drosophilid orthologies identified
Orthologs in non-Dipteran Insects (None identified)
No non-Dipteran orthologies identified
Orthologs in non-Insect Arthropods (None identified)
No non-Insect Arthropod orthologies identified
Orthologs in non-Arthropod Metazoa (None identified)
No non-Arthropod Metazoa orthologies identified
Human Orthologs (0)
Gene OMIM HGNC
AAA Orthologs (10) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD17337 Drosophila sechellia Dsec\GM13496 Drosophila erecta Dere\GG19105 Drosophila yakuba Dyak\GE17651 Drosophila ananassae Dana\GF22326 Drosophila pseudoobscura pseudoobscura Dpse\GA14858 Drosophila persimilis Dper\GL19878 Drosophila willistoni Dwil\GK18858 Drosophila virilis Dvir\GJ14890 Drosophila mojavensis Dmoj\GI15547
Stocks & Reagents
Stocks Listed in FlyBase ( 3 )
Bloomington	44198 y1 w* Mi{MIC}CG18258MI07578
VDRC	v101650 P{KK105335}VIE-260B v20621 w1118; P{GD9541}v20621
Genomic Clones ( 2 )
	BACR06G02 BACR18O02 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 3 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	IP12247
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones
Other clones	IP12147 IP12347
RNAi & Array Information
Linkouts
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: CG18258 anon-SAGE:Wang-051 (FlyBase, 1992-)
Additional comments
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_132973 RefSeq (Proteins) • NP_573201 DDBJ / EMBL / GenBank • AAF48708 CB305236 Entrez Gene - A searchable database of RefSeq genes. • 32708 UniProtKB/TrEMBL • Q9VX70
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Lipase (IPR000734) Lipase, N-terminal (IPR013818) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • IP12247
Linkouts
Synonyms & Secondary IDs ( 3 )
Reported As
Symbol Synonym	anon-SAGE:Wang-051   CG18258 (Takemori and Yamamoto, 2009, Horne et al., 2009, Keleman et al., 2009.8.5, Blanco et al., 2008) CT41369 (Ceriani et al., 2002)
Name Synonym	anon-SAGE:Wang-051
Secondary FlyBase IDs
	FBgn0030827 FBgn0066947
References ( 14 )
Research paper	Horne et al., 2009, Insect Biochem. Mol. Biol. 39(8): 547--567 Comparative and functional genomics of lipases in holometabolous insects. [FBrf0208359] Takemori and Yamamoto, 2009, Proteomics 9(9): 2484--2493 Proteome mapping of the Drosophila melanogaster male reproductive system. [FBrf0208046] Blanco et al., 2008, Genome Biol. 9(9): R134 Conserved chromosomal clustering of genes governed by chromatin regulators in Drosophila. [FBrf0207036] Ceriani et al., 2002, J. Neurosci. 22(21): 9305--9319 Genome-wide expression analysis in Drosophila reveals genes controlling circadian behavior. [FBrf0152147]
Supplementary material	Graveley et al., 2011, Nature 471(7339): Supplementary Table 33. Fuzzy Cluster Members. [FBrf0213980] Mummery-Widmer et al., 2009, Nature 458(7241): Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518]
Personal communication to FlyBase	Bellen, 2013.2.19, set1028.xml set1028.xml [FBrf0220967] Keleman et al., 2009.8.5, RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0208510] Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327] FlyBase Curators et al., 2004-, Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. [FBrf0174215]
FlyBase analysis	FlyBase Curators, 2010-, Gene Ontology (GO) annotation review. Gene Ontology (GO) annotation review. [FBrf0216433] FlyBase Curators, 2002-, Use of the ND evidence code for Gene Ontology (GO) terms in FlyBase. Use of the ND evidence code for Gene Ontology (GO) terms in FlyBase. [FBrf0159398] FlyBase, 1992-, FlyBase curation. FlyBase curation. [FBrf0105495]
Website	Fisher et al., 2012, BDGP insitu homepage BDGP insitu homepage [FBrf0219073]