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Gene Dmel\CG18234

General Information
Symbol	Dmel\CG18234	Species	D. melanogaster
Name		Annotation symbol	CG18234
Feature type	protein_coding_gene	FlyBase ID	FBgn0265268
Gene Model Status	Current	Stock availability	1 publicly available
Genomic Location
Chromosome (arm)	3L	Recombination map
Cytogenetic map	75D3-75D3	Sequence location	3L:18,596,525..18,598,515 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	This gene is referred to in FlyBase by the symbol Dmel\CG18234 (FBgn0265268). It is a protein_coding_gene from Drosophila melanogaster. An electronic pipeline based on InterPro domains suggests that it has the molecular function: oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen; iron ion binding; L-ascorbic acid binding; procollagen-proline 4-dioxygenase activity. An electronic pipeline based on InterPro domains suggests that it is involved in the biological process: oxidation-reduction process. One allele is reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: Oxoglutarate/iron-dependent dioxygenase; Prolyl 4-hydroxylase alpha-subunit, N-terminal; Prolyl 4-hydroxylase, alpha subunit. Gene sequence location is 3L:18596525..18598515.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03	Controlled Vocabulary Terms cellular_component molecular_function biological_process
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 75D3-75D3   Limits computationally determined from genome sequence between P{PZ}W05014 and P{lacW}l(3)j14E7j14E7
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\CG18234 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.44 Gene model reviewed during 5.46
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) CG18234-RC FBtr0300049  NM_140786   1575   515
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein CG18234-PC   FBpp0289326   58.9   515   5.46     NP_649043   AAF49255
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Prolyl 4-hydroxylase, alpha subunit (IPR006620) Prolyl 4-hydroxylase alpha-subunit, N-terminal (IPR013547) Oxoglutarate/iron-dependent dioxygenase (IPR005123)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014296 AAF49255   AI947140   BT022668   CB305240   EL882377   EL882612
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VVQ5
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
[an error occurred while processing this directive] FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
[an error occurred while processing this directive]
modENCODE Development RNA-Seq
[an error occurred while processing this directive] modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
[an error occurred while processing this directive]
modENCODE Treatments RNA-Seq
[an error occurred while processing this directive]
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (Graveley et al., 2011) mE1_20_mRNA_expression_cluster_20
External Data & Images
Linkouts
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 CG18234GD8813 Phenotype manifest in Allele
Classical Alleles ( 0 )
For All Classical Alleles Show
Allele of CG18234 Class Mutagen Stocks Known lesion
Alleles Carried on Transgenic Constructs ( 1 )
For All Alleles Carried on Transgenic Constructs Show
Allele of CG18234 Class Mutagen Stocks Known lesion CG18234GD8813 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes
Aneuploid Aberrations
Disrupted in	Df(3L)Exel6134 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD8813} NA
Insertions
	Type of insertions Name Expression data
Gene Ontology: Function, Process & Cellular Component ( 6 unique terms )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 6 terms )
Molecular Function
CV term Evidence References
iron ion binding inferred from electronic annotation with InterPro:IPR006620 (FlyBase Curators et al., 2004-) L-ascorbic acid binding inferred from electronic annotation with InterPro:IPR006620 (FlyBase Curators et al., 2004-) oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen inferred from electronic annotation with InterPro:IPR013547 (FlyBase Curators et al., 2004-) procollagen-proline 4-dioxygenase activity inferred from electronic annotation with InterPro:IPR013547 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
oxidation-reduction process inferred from electronic annotation with InterPro:IPR005123, InterPro:IPR006620, InterPro:IPR013547 (FlyBase Curators et al., 2004-)
Cellular Component
CV term Evidence References
endoplasmic reticulum inferred from electronic annotation with InterPro:IPR013547 (FlyBase Curators et al., 2004-)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions CG18234 allele Gene References
External Data
Linkouts
Orthologs
OrthoDB Orthologs (10) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6DV660 Dipteran inclusive ortholog search No orthologs identified Insect inclusive ortholog search No orthologs identified Arthropod inclusive ortholog search No orthologs identified Metazoa inclusive ortholog search No orthologs identified
Orthologs in Drosophila Species (EOG6DV660)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\CG18234     Drosophila simulans   Dsim\GD14754 Y   Drosophila sechellia   Dsec\GM14977 Y   Drosophila erecta   Dere\GG13661 Y   Drosophila yakuba   Dyak\GE19958 Y   Drosophila ananassae   Dana\GF23627 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA23908 Y   Drosophila persimilis   Dper\GL22879 Y   Drosophila virilis   Dvir\GJ13932 Y   Drosophila mojavensis   Dmoj\GI13593 Y
Orthologs in non-Drosophila Dipterans (None identified)
No non-Drosophilid orthologies identified
Orthologs in non-Dipteran Insects (None identified)
No non-Dipteran orthologies identified
Orthologs in non-Insect Arthropods (None identified)
No non-Insect Arthropod orthologies identified
Orthologs in non-Arthropod Metazoa (None identified)
No non-Arthropod Metazoa orthologies identified
Human Orthologs (0)
Gene OMIM HGNC
AAA Orthologs (9) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD14754 Drosophila sechellia Dsec\GM14977 Drosophila erecta Dere\GG13661 Drosophila yakuba Dyak\GE19958 Drosophila ananassae Dana\GF23627 Drosophila pseudoobscura pseudoobscura Dpse\GA23908 Drosophila persimilis Dper\GL22879 Drosophila virilis Dvir\GJ13932 Drosophila mojavensis Dmoj\GI13593
Stocks & Reagents
Stocks Listed in FlyBase ( 1 )
VDRC	v19187 w1118; P{GD8813}v19187/TM3
Genomic Clones ( 2 )
	BACR17L05 BACR23M20 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 4 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	IP12246
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones
Other clones	bs35e09 IP12146 IP12346
RNAi & Array Information
Linkouts
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: CG18234 anon-SAGE:Wang-055 (FlyBase, 1992-)
Additional comments
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_140786 RefSeq (Proteins) • NP_649043 DDBJ / EMBL / GenBank • AAF49255 AI947140 CB305240 Entrez Gene - A searchable database of RefSeq genes. • 40024 UniProtKB/TrEMBL • Q9VVQ5
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Prolyl 4-hydroxylase, alpha subunit (IPR006620) Prolyl 4-hydroxylase alpha-subunit, N-terminal (IPR013547) Oxoglutarate/iron-dependent dioxygenase (IPR005123)
Linkouts
Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	anon-SAGE:Wang-055   CG18234 (Ravi Ram and Wolfner, 2007, Ravi Ram and Wolfner, 2007, )
Name Synonym	anon-SAGE:Wang-055
Secondary FlyBase IDs
	FBgn0036794 FBgn0066943
References ( 11 )
Supplementary material	Graveley et al., 2011, Nature 471(7339): Supplementary Table 33. Fuzzy Cluster Members. [FBrf0213980] Mummery-Widmer et al., 2009, Nature 458(7241): Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518] Ravi Ram and Wolfner, 2007, Integr. Comp. Biol. 47(3): Supplementary Material. [FBrf0219931]
Review	Ravi Ram and Wolfner, 2007, Integr. Comp. Biol. 47(3): 427--445 Seminal influences: Drosophila Acps and the molecular interplay between males and females during reproduction. [FBrf0216187]
Personal communication to FlyBase	Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327] FlyBase Curators et al., 2004-, Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. [FBrf0174215] Ryder, 2004.4.26, Exelixis CG deletion data. Exelixis CG deletion data. [FBrf0184335] Oliver, 2001.8.16, Genome Res.: File from B. Oliver containing information on ESTs expressed in the Drosophila testis, described in Andrews et al., 2000, Genome Res. 10(12): 2030-2043 (FBrf0132348). [FBrf0137492]
FlyBase analysis	FlyBase Curators, 2010-, Gene Ontology (GO) annotation review. Gene Ontology (GO) annotation review. [FBrf0216433] FlyBase Curators, 2002-, Use of the ND evidence code for Gene Ontology (GO) terms in FlyBase. Use of the ND evidence code for Gene Ontology (GO) terms in FlyBase. [FBrf0159398] FlyBase, 1992-, FlyBase curation. FlyBase curation. [FBrf0105495]