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Gene Dmel\CG14717

General Information
Symbol	Dmel\CG14717	Species	D. melanogaster
Name		Annotation symbol	CG14717
Feature type	protein_coding_gene	FlyBase ID	FBgn0265271
Gene Model Status	Current	Stock availability	2 publicly available
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	86E16-86E16	Sequence location	3R:7,522,231..7,524,049 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	This gene is referred to in FlyBase by the symbol Dmel\CG14717 (FBgn0265271). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: hydrolase activity. The biological processes in which it is involved are not known. 2 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. Gene sequence location is 3R:7522231..7524049.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03	Controlled Vocabulary Terms cellular_component carboxylesterase activity biological_process
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 86E16-86E16   Limits computationally determined from genome sequence between P{PZ}tho1&P{PZ}l(3)0462905275 and P{EP}Lk6EP886
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\CG14717 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.47
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) CG14717-RA FBtr0082425  NM_141849   1154   306 CG14717-RB FBtr0335209  NM_001275552   1819   306
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein CG14717-PA   FBpp0081901   34.2   306   6.72     NP_650106   AAF54685 CG14717-PB   FBpp0307196   34.2   306   6.72     NP_001262481   AGB95863
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014297 AAF54685   AI261146   AI944919   AI946118   AY119027 AAM50887   BE977424   BE978256   CB305311
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VGJ4
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
[an error occurred while processing this directive] FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
[an error occurred while processing this directive]
modENCODE Development RNA-Seq
[an error occurred while processing this directive] modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
[an error occurred while processing this directive]
modENCODE Treatments RNA-Seq
[an error occurred while processing this directive]
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (Graveley et al., 2011) mE1_20_mRNA_expression_cluster_19
External Data & Images
Linkouts	BDGP expression data • LP05266
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 CG14717GD8420 Phenotype manifest in Allele
Classical Alleles ( 0 )
For All Classical Alleles Show
Allele of CG14717 Class Mutagen Stocks Known lesion
Alleles Carried on Transgenic Constructs ( 2 )
For All Alleles Carried on Transgenic Constructs Show
Allele of CG14717 Class Mutagen Stocks Known lesion CG14717GD8420 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes CG14717NIG.14717R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3R)Exel7309 (Ryder, 2004.4.26) Df(3R)Exel8154 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD8420} NA P{NIG.14717R} NA
Insertions
	Type of insertions Name Expression data
Gene Ontology: Function, Process & Cellular Component ( 1 unique term )
	There is no information supporting a biological process or cellular component term for this gene. (Based on a review of available data on: 2013-02-15)
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 1 term )
Molecular Function
CV term Evidence References
carboxylesterase activity inferred from sequence or structural similarity with CG2059 (Curators, 2008--)
Biological Process ( 0 terms)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
CG14717 - ATPsyn-γ anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG14717 - CG7033 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG14717 - Ent1 anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) CG14717 - Hsp22 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG14717 - Hsp23 experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting (Guruharsha et al., 2011, Mintseris et al., 2009.11.23) CG14717 - Hsp27 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG14717 - ImpL3 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG14717 - ref(2)P anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions CG14717 allele Gene References
External Data
Linkouts
Orthologs
OrthoDB Orthologs (48) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6Q2F1Z Dipteran inclusive ortholog search No orthologs identified Insect inclusive ortholog search EOG6RXWW7 Arthropod inclusive ortholog search EOG6J6Q6V Metazoa inclusive ortholog search EOG6JTC0J
Orthologs in Drosophila Species (EOG6Q2F1Z)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\CG14717     Drosophila simulans   Dsim\GD18776 Y   Drosophila sechellia   Dsec\GM23971 Y   Drosophila erecta   Dere\GG18366 Y   Drosophila yakuba   Dyak\GE24195 Y   Drosophila ananassae   Dana\GF18391 Y   Drosophila virilis   Dvir\GJ10894 Y   Drosophila mojavensis   Dmoj\GI24075 Y   Drosophila grimshawi   Dgri\GH18268 Y
Orthologs in non-Drosophila Dipterans (None identified)
No non-Drosophilid orthologies identified
Orthologs in non-Dipteran Insects (EOG6RXWW7)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB53188 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG003701 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH21898 Y Atta cephalotes Leafcutter ant  Acep\ACEP26668 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO18445 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL19972 Y Linepithema humile Argentine ant  Lhum\LH13225 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB16020 Y Solenopsis invicta Red fire ant  Sinv\SINV22802 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI004279 Y Bombyx mori Silkmoth  Bmor\BGIBMGA013114 Y Pediculus humanus Human body louse  Phum\PHUM609380 Y Tribolium castaneum Red flour beetle  Tcas\GLEAN_15318 Y
Orthologs in non-Insect Arthropods (EOG6J6Q6V)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\pgiC2 Y Ixodes scapularis Deer tick  Isca\ISCW006915 Y
Orthologs in non-Arthropod Metazoa (EOG6JTC0J)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\C37H5.2 Y Caenorhabditis elegans Nematode  Cele\R05D7.4 Y Caenorhabditis elegans Nematode  Cele\C25A1.12 Y Caenorhabditis elegans Nematode  Cele\F32B4.6 Y Caenorhabditis elegans Nematode  Cele\C37H5.3 Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_009029gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_024138gn Y Danio rerio Zebrafish  Drer\abhd11 Y Danio rerio Zebrafish  Drer\ENSDARG00000078831 Y Danio rerio Zebrafish  Drer\abhd5 Y Danio rerio Zebrafish  Drer\abhd4 Y Xenopus tropicalis Western clawed frog  Xtro\abhd5 Y Xenopus tropicalis Western clawed frog  Xtro\abhd11 Y Xenopus tropicalis Western clawed frog  Xtro\abhd4 Y Gallus gallus Domestic chicken  Ggal\ABHD5 Y Gallus gallus Domestic chicken  Ggal\ABHD11 Y Mus musculus House mouse  Mmus\Abhd5 Y Mus musculus House mouse  Mmus\Abhd11 Y Mus musculus House mouse  Mmus\Abhd4 Y Rattus norvegicus Norway rat  Rnor\Abhd4 Y Rattus norvegicus Norway rat  Rnor\LOC686139 Y Rattus norvegicus Norway rat  Rnor\Abhd5 Y Homo sapiens Human  Hsap\ENSG00000106077 Y Homo sapiens Human  Hsap\ABHD4 Y
Human Orthologs (2)
Gene OMIM HGNC Hsap\ENSG00000106077     Hsap\ABHD4
AAA Orthologs (9) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD18776 Drosophila sechellia Dsec\GM23971 Drosophila erecta Dere\GG18366 Drosophila yakuba Dyak\GE24195 Drosophila ananassae Dana\GF18391 Drosophila willistoni Dwil\GK19111 Drosophila virilis Dvir\GJ10894 Drosophila mojavensis Dmoj\GI24075 Drosophila grimshawi Dgri\GH18268
Stocks & Reagents
Stocks Listed in FlyBase ( 2 )
VDRC	v38813 w1118; P{GD8420}v38813 v38814 w1118; P{GD8420}v38814
Genomic Clones ( 1 )
	BACR11G22 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 6 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LP05266
Other clones	DPiM_LP05266
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones
Other clones	bs07a03 bs21b03 bs63h03 bs76a04
RNAi & Array Information
Linkouts
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: CG14717 anon-SAGE:Wang-126 (FlyBase, 1992-)
Additional comments
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_141849 NM_001275552 RefSeq (Proteins) • NP_650106 NP_001262481 DDBJ / EMBL / GenBank • AAF54685 AAM50887 AI261146 AI944919 AI946118 AY119027 CB305311 Entrez Gene - A searchable database of RefSeq genes. • 41412 UniProtKB/TrEMBL • Q9VGJ4
Other Crossreferences
	BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • LP05266
Linkouts
Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	anon-SAGE:Wang-126   CG14717 (Japanese National Institute of Genetics, 2012.5.21, Grath et al., 2009, Lebo et al., 2009)
Name Synonym	anon-SAGE:Wang-126
Secondary FlyBase IDs
	FBgn0037938 FBgn0066872
References ( 15 )
Research paper	Grath et al., 2009, BMC Evol. Biol. 9: 291 Molecular evolution of sex-biased genes in the Drosophila ananassae subgroup. [FBrf0209770] Lebo et al., 2009, BMC Genomics 10: 80 Somatic, germline and sex hierarchy regulated gene expression during Drosophila metamorphosis. [FBrf0207472]
Supplementary material	Graveley et al., 2011, Nature 471(7339): Supplementary Table 33. Fuzzy Cluster Members. [FBrf0213980] Guruharsha et al., 2011, Cell 147(3): Table S3. [FBrf0218395] Mummery-Widmer et al., 2009, Nature 458(7241): Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518]
Personal communication to FlyBase	Mintseris et al., 2009.11.23, DPiM: the Drosophila Protein Interaction Mapping project DPiM: the Drosophila Protein Interaction Mapping project [FBrf0209452] Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327] Ryder, 2004.4.26, Exelixis CG deletion data. Exelixis CG deletion data. [FBrf0184335] Oliver, 2001.8.16, Genome Res.: File from B. Oliver containing information on ESTs expressed in the Drosophila testis, described in Andrews et al., 2000, Genome Res. 10(12): 2030-2043 (FBrf0132348). [FBrf0137492] BDGP Project Members, 2000-, Berkeley Drosophila Genome Project. (Computer file) Berkeley Drosophila Genome Project. (Computer file) [FBrf0125078]
FlyBase analysis	Curators, 2008--, Assigning Gene Ontology (GO) terms by sequence similarity in FlyBase. Assigning Gene Ontology (GO) terms by sequence similarity in FlyBase. [FBrf0202953] FlyBase Curators, 2002-, Use of the ND evidence code for Gene Ontology (GO) terms in FlyBase. Use of the ND evidence code for Gene Ontology (GO) terms in FlyBase. [FBrf0159398] FlyBase, 1992-, FlyBase curation. FlyBase curation. [FBrf0105495]
Stock list	Japanese National Institute of Genetics, 2012.5.21, RNAi stocks available from NIG-FLY. RNAi stocks available from NIG-FLY. [FBrf0218457]