A Database of Drosophila Genes & Genomes

FB2013_03, released May 7th, 2013
 

Gene Dmel\Inx3

General Information
SymbolDmel\Inx3SpeciesD. melanogaster
NameInnexin 3Annotation symbolCG1448
Feature typeprotein_coding_geneFlyBase IDFBgn0265274
Gene Model StatusCurrent Stock availability 4 publicly available
Also Known Asinx-3, Dm-inx3
Genomic Location
Chromosome (arm)3RRecombination map
Cytogenetic map98E6-98F1Sequence location3R:24,679,328..24,684,936 [-]

Genomic Maps

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Automatically generated summary

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The gene Innexin 3 is referred to in FlyBase by the symbol Dmel\Inx3 (CG1448, FBgn0265274). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: gap junction channel activity. There is experimental evidence that it is involved in the biological process: intercellular transport. 5 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Innexin. Gene sequence location is 3R:24679328..24684936.
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Description
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This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms).
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FB2013_03
FB2013_02
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hide Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map
Evidence for location
98E6-98F1  
Limits computationally determined from genome sequence between P{PZ}l(3)0648706487 and P{EP}EP3390EP3390  
Experimentally Determined Cytological Location
Cytogenetic map
Notes
References
98E4-98E6  
98E4-98E6  
(determined by in situ hybridisation)  
98E4-98E6  
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
hide Gene Model & Products
Please see the GBrowse view of Dmel\Inx3 for information on other features GBrowse View Help
To submit a correction to a gene model please use the Contact FlyBase form
detailed view FBtr0330303 FBtr0330304 FBtr0330305 FBtr0336766 FBtr0336765 FBtr0330306 FBtr0085350 FBpp0303337 FBpp0307742 FBpp0303335 FBpp0303336 FBpp0307741 FBpp0084719 FBpp0303338
Comments on Gene Model
Gene model reviewed during 5.48
Gene model reviewed during 5.44
hide Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Associated CDS (aa)
FBtr0085350
  1605
  395
FBtr0330306
  2136
  395
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
hide Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank protein
FBpp0084719  
45.4  
395  
8.58  
FBpp0303338  
45.4  
395  
8.58  
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences
InterPro domains - A database of protein families, domains, and functional sites
Innexin (IPR000990)
hide Sequences Consistent with the Gene Model
DDBJ /
EMBL /
GenBank
DNA sequence
Protein sequence
Name
 
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL
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Mapped Features have been reorganized, please see this article for details.
Additional mapped features and mutations can be found on GBrowse or related reports.
Type
Symbol & Location
Additional Notes
References
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Linkouts
Crossreferences
hide Expression Data
hideTranscript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
hide Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term
References
inferred from direct assay
inferred from direct assay
(assigned by UniProtKB)
inferred from direct assay
hide Expression Deduced from Reporters
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Associated Tools
Reference
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
hide FlyAtlas Anatomy Microarray
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FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
hide modENCODE Anatomy RNA-Seq
[an error occurred while processing this directive]
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[an error occurred while processing this directive]
modENCODE Temporal Expression Data (Graveley et al., 2011)
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[an error occurred while processing this directive]
hide Expression Clusters
A cluster of genes with similar mRNA expression dynamics across development.
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Linkouts
hide Alleles & Phenotypes
hide Summary of Allele Phenotypes
Lethality
Allele
Phenotype manifest in
Allele
hide Classical Alleles ( 0 )
For All Classical Alleles Show

Allele of Inx3ClassMutagenStocksKnown lesion
hide Alleles Carried on Transgenic Constructs ( 5 )
For All Alleles Carried on Transgenic Constructs Show

Allele of Inx3ClassMutagenStocksKnown lesion
Inx3GD149653 Yes
Inx3HM052451 Yes
Inx3GD3400 Yes
Inx3KK1062680 Yes
Inx3Scer\UAS.cSa0 Yes
hide Aneuploid Aberrations
Disrupted in
hide Transgenic Constructs & Insertions
Transgenic Constructs
Type of construct
Name
Expression data
Insertions
Type of insertions
Name
Expression data
hide Gene Ontology: Function, Process & Cellular Component ( 5 unique terms )
hide Terms Based on Experimental Evidence ( 5 terms )
Molecular Function
CV term
References
Biological Process
CV term
References
Cellular Component
CV term
References
inferred from direct assay
inferred from direct assay
(assigned by UniProtKB)
inferred from direct assay
hide Terms Based on Predictions or Assertions ( 2 terms )
Molecular Function
CV term
References
Biological Process ( 0 terms)
Cellular Component
CV term
References
inferred from sequence or structural similarity with EMBL:AF115854
hide Sequence Ontology: Class of Gene
hide Interactions & Pathways
hide Summary of Physical Interactions
protein-protein
Interacting group
Assay
References
anti tag coimmunoprecipitation, peptide massfingerprinting
anti tag coimmunoprecipitation, peptide massfingerprinting
anti tag coimmunoprecipitation, peptide massfingerprinting
anti tag coimmunoprecipitation, peptide massfingerprinting
anti tag coimmunoprecipitation, peptide massfingerprinting
anti tag coimmunoprecipitation, peptide massfingerprinting
anti tag coimmunoprecipitation, peptide massfingerprinting
anti tag coimmunoprecipitation, peptide massfingerprinting
anti tag coimmunoprecipitation, peptide massfingerprinting
anti tag coimmunoprecipitation, peptide massfingerprinting
anti tag coimmunoprecipitation, peptide massfingerprinting
anti tag coimmunoprecipitation, peptide massfingerprinting
anti tag coimmunoprecipitation, peptide massfingerprinting
anti tag coimmunoprecipitation, peptide massfingerprinting
anti tag coimmunoprecipitation, peptide massfingerprinting
anti tag coimmunoprecipitation, peptide massfingerprinting
anti tag coimmunoprecipitation, peptide massfingerprinting
anti tag coimmunoprecipitation, peptide massfingerprinting
anti tag coimmunoprecipitation, peptide massfingerprinting
anti tag coimmunoprecipitation, peptide massfingerprinting
anti tag coimmunoprecipitation, peptide massfingerprinting
hide Summary of Genetic Interactions
Interacts with
Please look at the allele data for full details of the genetic interactions
Inx3 allele
Gene
References
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Linkouts
hide Orthologs
hide OrthoDB Orthologs (38) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
Drosophila inclusive ortholog search
Dipteran inclusive ortholog search
Insect inclusive ortholog search
Arthropod inclusive ortholog search
Metazoa inclusive ortholog search
hideOrthologs in Drosophila Species (EOG6NKCFD)
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila melanogaster
fruit fly 
 
 
Drosophila simulans
 
Y
 
Drosophila sechellia
 
Y
 
Drosophila erecta
 
Y
 
Drosophila yakuba
 
Y
 
Drosophila ananassae
 
Y
 
Drosophila pseudoobscura pseudoobscura
 
Y
 
Drosophila persimilis
 
Y
 
Drosophila willistoni
 
Y
 
Drosophila virilis
 
Y
 
Drosophila mojavensis
 
Y
 
Drosophila grimshawi
 
Y
 
hideOrthologs in non-Drosophila Dipterans (EOG63FH5F)
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Aedes aegypti
Yellow fever mosquito 
 
Anopheles gambiae
Malaria mosquito 
 
Culex quinquefasciatus
Southern house mosquito 
 
hideOrthologs in non-Dipteran Insects (EOG6Z0924)
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Apis mellifera
Western honey bee 
Amel\inx3
 
Nasonia vitripennis
Parasitic wasp 
Nvit\Nasvi2EG016016
 
Acromyrmex echinatior
Panamanian leafcutter ant 
Aech\AECH12792
 
Atta cephalotes
Leafcutter ant 
Acep\ACEP22071
 
Camponotus floridanus
Florida carpenter ant 
Cflo\CFLO14822
 
Harpegnathos saltator
Jerdons jumping ant 
Hsal\HSAL15440
 
Linepithema humile
Argentine ant 
Lhum\LH12198
 
Pogonomyrmex barbatus
Red harvester ant 
Pbar\PB16326
 
Solenopsis invicta
Red fire ant 
Sinv\SINV12041
 
Acyrthosiphon pisum
Pea aphid 
 
Bombyx mori
Silkmoth 
 
Pediculus humanus
Human body louse 
 
Tribolium castaneum
Red flour beetle 
 
hideOrthologs in non-Insect Arthropods (EOG695X76)
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Daphnia pulex
Water flea 
 
Daphnia pulex
Water flea 
 
hideOrthologs in non-Arthropod Metazoa (EOG65XMPR)
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Caenorhabditis elegans
Nematode 
Y
Caenorhabditis elegans
Nematode 
Y
Caenorhabditis elegans
Nematode 
Y
Caenorhabditis elegans
Nematode 
Y
Caenorhabditis elegans
Nematode 
Y
Caenorhabditis elegans
Nematode 
Y
Caenorhabditis elegans
Nematode 
Y
Caenorhabditis elegans
Nematode 
Y
hide Human Orthologs (0)
Gene
OMIM
HGNC
hideAAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism
Gene
Drosophila simulans
Drosophila sechellia
Drosophila erecta
Drosophila yakuba
Drosophila ananassae
Drosophila pseudoobscura pseudoobscura
Drosophila persimilis
Drosophila willistoni
Drosophila virilis
Drosophila mojavensis
Drosophila grimshawi
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hide Stocks Listed in FlyBase ( 4 )
Bloomington
VDRC
hide Genomic Clones ( 2 )
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
hide cDNA Clones ( 109 )
Please Note
This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones
Other clones
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Linkouts
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hide Identification
hide Relationship to Other Genes
Source for database identity of
Source for identity of: Inx3 inx3
Source for database merge of
Source for merge of: Inx3 anon-EST:fe2B11
Source for merge of: inx3 CG1448
Additional comments
Source for merge of inx3 CG1448 was sequence comparison (date:000815).
hide Other Comments
dsRNA has been made from templates generated with primers directed against this gene.
hide External Crossreferences & Linkouts
Sequence Crossreferences
RefSeq (Transcripts)
RefSeq (Proteins)
Entrez Gene - A searchable database of RefSeq genes.
Other Crossreferences
InterPro domains - A database of protein families, domains, and functional sites
Innexin (IPR000990)
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
Linkouts
hide Synonyms & Secondary IDs ( 15 )
Reported As
Symbol Synonym
anon-EST:fe2B11
 
Name Synonym
anon-fast-evolving-2B11
 
Secondary FlyBase IDs
  • FBgn0025230
  • FBgn0028373
  • FBgn0039606
hide References ( 48 )
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hide Recent research papers ( 2 )
Ayukawa et al., 2012, Proc. Natl. Acad. Sci. U.S.A. 109(38): 15318--15323
Rescue of Notch signaling in cells incapable of GDP-L-fucose synthesis by gap junction transfer of GDP-L-fucose in Drosophila. [FBrf0219480]
Wu et al., 2011, Curr. Biol. 21(10): 848--854
Heterotypic Gap Junctions between Two Neurons in the Drosophila Brain Are Critical for Memory. [FBrf0213804]
hide Recent reviews ( 1 )
Abascal and Zardoya, 2013, Biochim. Biophys. Acta 1828(1): 4--14
Evolutionary analyses of gap junction protein families. [FBrf0219962]