FB2025_04 , released October 2, 2025
Gene: Dmel\pAbp
Open Close
General Information
Symbol
Dmel\pAbp
Species
D. melanogaster
Name
poly(A) binding protein
Annotation Symbol
CG5119
Feature Type
protein_coding_gene
FlyBase ID
FBgn0265297
Gene Model Status
Current
Stock Availability
24 publicly available
Gene Summary
Binds the poly(A) tail of mRNA (PubMed:2125288). Since it interacts with the cap-associating translation initiation factor eIF4G, it is likely that it functions by linking Atx2 to the cap-binding complex (PubMed:28388438). Forms a complex with tyf and Atx2 which functions in adult circadian pacemaker neurons to sustain circadian rhythms likely by switching between activator and repressor modes of post-transcriptional regulation via interaction with Lsm12a or me31B, respectively (PubMed:28388438). The activator complex (Atx2-tyf activator complex) activates the TYF-dependent translation of per to maintain 24 hour periodicity in circadian locomotor behaviors, whereas the repressor complex (Atx2-Not1 repressor complex) promotes Not1-dependent post-transcriptional gene silencing and supports high-amplitude circadian rhythms in a per-independent manner (PubMed:28388438). In 0-1 hour embryos, forms a ribonucleoprotein complex (RNP) with me31B, eIF4E1, tral and cup which binds to various mRNAs including maternal mRNAs, and down-regulates their expression during the maternal-to-zygotic transition (PubMed:28875934). Involved in germline stem cell transit amplification, differentiation and mitosis-to-meiosis transition (PubMed:28190776). (UniProt, P21187)
Contribute a Gene Snapshot for this gene.
All Summaries
Also Known As

PABPC1, dPABP, polyA-binding protein, PABP55B, l(2)k10109

Key Links
Genomic Location
Cytogenetic map
55B8-55B9
Sequence location
Recombination map
2-84
RefSeq locus
NT_033778 REGION:18140078..18147191
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (25 terms)
Molecular Function (7 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
enables mRNA 3'-UTR binding
inferred from direct assay
(Vazquez-Pianzola et al., 2011, Nelson et al., 2007)
enables poly(A) binding
inferred from direct assay
(Benoit et al., 2005)
enables protein binding
inferred from physical interaction with FLYBASE:Paip2; FB:FBgn0038100
(Roy et al., 2004)
inferred from physical interaction with UniProtKB:Q8SY33
(Zekri et al., 2009)
inferred from physical interaction with UniProtKB:B7Z0E2
(Hollmann et al., 2023)
Terms Based on Predictions or Assertions (6 terms)
CV Term
Evidence
References
enables mRNA 3'-UTR binding
inferred from biological aspect of ancestor with PANTHER:PTN000610044
(GO Reference Genome Project, 2011-)
enables mRNA binding
inferred from sequence or structural similarity
(Lasko, 2000)
enables nucleic acid binding
inferred from electronic annotation with InterPro:IPR035979
(InterPro Project Members, 2004-)
enables poly(A) binding
inferred from sequence or structural similarity with SGD:S000000967
(Mount and Salz, 2000)
traceable author statement
(Johnstone and Lasko, 2001)
inferred from biological aspect of ancestor with PANTHER:PTN000610044
(GO Reference Genome Project, 2011-)
enables poly(U) RNA binding
inferred from biological aspect of ancestor with PANTHER:PTN000610044
(GO Reference Genome Project, 2011-)
enables RNA binding
(InterPro Project Members, 2004-)
Biological Process (11 terms)
Terms Based on Experimental Evidence (10 terms)
CV Term
Evidence
References
involved_in chemical synaptic transmission
inferred from mutant phenotype
(Reiff et al., 2002)
involved_in dorsal/ventral pattern formation
inferred from mutant phenotype
(Clouse et al., 2008)
involved_in male meiosis cytokinesis
inferred from mutant phenotype
(Pertceva et al., 2010)
involved_in male meiotic nuclear division
inferred from mutant phenotype
(Blagden et al., 2009)
involved_in oocyte development
inferred from mutant phenotype
(Vazquez-Pianzola et al., 2011)
involved_in oogenesis
inferred from mutant phenotype
(Clouse et al., 2008)
involved_in positive regulation of translation
inferred from genetic interaction with FLYBASE:grk; FB:FBgn0001137
(Clouse et al., 2008)
involved_in regulation of compound eye photoreceptor development
inferred from genetic interaction with FLYBASE:pAbp; FB:FBgn0265297
(Lessing and Bonini, 2008)
involved_in spermatid nucleus differentiation
inferred from mutant phenotype
(Pertceva et al., 2010)
involved_in spermatogenesis
inferred from mutant phenotype
(Pertceva et al., 2010)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
involved_in mRNA splicing, via spliceosome
inferred by curator from GO:0071011,GO:0071013
(Herold et al., 2009)
involved_in positive regulation of translation
traceable author statement
(Johnstone and Lasko, 2001)
Cellular Component (7 terms)
Terms Based on Experimental Evidence (6 terms)
CV Term
Evidence
References
part_of catalytic step 2 spliceosome
inferred from high throughput direct assay
(Herold et al., 2009)
located_in cytoplasm
inferred from direct assay
(Vazquez-Pianzola et al., 2011, Sigrist et al., 2000)
located_in cytosol
inferred from high throughput direct assay
(Lye et al., 2014)
located_in nucleus
inferred from high throughput direct assay
(Lee et al., 2014)
part_of precatalytic spliceosome
inferred from high throughput direct assay
(Herold et al., 2009)
part_of ribonucleoprotein complex
inferred from direct assay
(Nelson et al., 2007)
Terms Based on Predictions or Assertions (4 terms)
CV Term
Evidence
References
is_active_in cytoplasmic stress granule
inferred from biological aspect of ancestor with PANTHER:PTN000610046
(GO Reference Genome Project, 2011-)
is_active_in cytosol
inferred from biological aspect of ancestor with PANTHER:PTN000610044
(GO Reference Genome Project, 2011-)
is_active_in nucleus
inferred from biological aspect of ancestor with PANTHER:PTN000610044
(GO Reference Genome Project, 2011-)
part_of ribonucleoprotein complex
inferred from biological aspect of ancestor with PANTHER:PTN002768817
(GO Reference Genome Project, 2011-)
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the polyadenylate-binding protein type-1 family. (P21187)
Protein Signatures (InterPro)
Summaries
Protein Function (UniProtKB)
Binds the poly(A) tail of mRNA (PubMed:2125288). Since it interacts with the cap-associating translation initiation factor eIF4G, it is likely that it functions by linking Atx2 to the cap-binding complex (PubMed:28388438). Forms a complex with tyf and Atx2 which functions in adult circadian pacemaker neurons to sustain circadian rhythms likely by switching between activator and repressor modes of post-transcriptional regulation via interaction with Lsm12a or me31B, respectively (PubMed:28388438). The activator complex (Atx2-tyf activator complex) activates the TYF-dependent translation of per to maintain 24 hour periodicity in circadian locomotor behaviors, whereas the repressor complex (Atx2-Not1 repressor complex) promotes Not1-dependent post-transcriptional gene silencing and supports high-amplitude circadian rhythms in a per-independent manner (PubMed:28388438). In 0-1 hour embryos, forms a ribonucleoprotein complex (RNP) with me31B, eIF4E1, tral and cup which binds to various mRNAs including maternal mRNAs, and down-regulates their expression during the maternal-to-zygotic transition (PubMed:28875934). Involved in germline stem cell transit amplification, differentiation and mitosis-to-meiosis transition (PubMed:28190776).
(UniProt, P21187)
Summary (Interactive Fly)

RNA-binding protein involved in translational regulation and nonsense-mediated mRNA decay - interactions of GW182 proteins with PABP and deadenylases are required for both translational repression and degradation of miRNA targets

Gene Model and Products
Number of Transcripts
3
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\pAbp for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry P21187)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
PDB - An information portal to biological macromolecular structures
Comments on Gene Model

Gene model reviewed during 5.44

Low-frequency RNA-Seq exon junction(s) not annotated.

Annotated transcripts do not represent all supported alternative splices within 5' UTR.

Gene model reviewed during 5.50

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
pAbp-RA
FBtr0086738
NM_057319
2433
634
pAbp-RB
FBtr0086740
NM_166264
3870
634
pAbp-RC
FBtr0086736
NM_166265
3127
634
Additional Transcript Data and Comments
Reported size (kB)

3.8 (northern blot)

(Lefrere et al., 1990)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
pAbp-PA
FBpp0085917
69.9
634
9.80
P21187
NP_476667
AAM68175
pAbp-PB
FBpp0085919
69.9
634
9.80
P21187
NP_725749
AAF57745
pAbp-PC
FBpp0085915
69.9
634
9.80
P21187
NP_725750
AAF57746
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

634 aa isoforms: pAbp-PA, pAbp-PB, pAbp-PC
Additional Polypeptide Data and Comments
Reported size (kDa)

632 (aa)

(Lefrere et al., 1993)
Comments
External Data
Subunit Structure (UniProtKB)

Core component of the neuromuscular Atx2 complex, composed of at least Atx2, tyf, pAbp, Lsm12a (PubMed:28388438). Interacts with Atx2 (via PAM2 motif) (PubMed:28388438). Atx2 and pAbp form a subcomplex that can associate with the 5' cap of pre-mRNAs independently of tyf, Lsm12a or me31B (PubMed:28388438). Forms a ribonucleoprotein complex (RNP) containing at least me31B, eIF4E1, cup, tral and pAbp; this interaction is required for the translational silencing of maternal mRNAs during the maternal-to-zygotic transition (PubMed:28875934). In 1-5 hour embryos, interaction with me31B is severely reduced and there is no detected interaction with cup and tral, however interaction with eIF4E1 and eIF4G1 remains unchanged (PubMed:28875934). Interacts with gw; this interaction interferes with the binding of pAbp to eIF4G and is required for miRNA-mediated silencing (PubMed:19797087). Interacts with larp (PubMed:19631203). Interacts with Unr (PubMed:36688322).

(UniProt, P21187)
Crossreferences
InterPro - A database of protein families, domains and functional sites
PDB - An information portal to biological macromolecular structures
Linkouts
Sequences Consistent with the Gene Model
Nucleotide / Polypeptide Records
 
UniProt
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\pAbp using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.43

Transcript Expression
expression microarray
Stage
Tissue/Position (including subcellular localization)
Reference
wandering third instar larval stage
wing disc
(Mohit et al., 2006)
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1 -- 3
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 1 -- 4
pole plasm | posterior
(Lecuyer et al., 2007)
embryonic stage 4 -- 6
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 5
primordial germ cell
(Lecuyer et al., 2007)
embryonic stage 7 -- 8
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 9 -- 10
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 11 -- 12
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 13 -- 16
organism | ubiquitous
(Fisher et al., 2012)
wandering third instar larval stage
dorsal-ventral compartment boundary of the wing disc | dorsal to | restricted

Comment: anterior compartment only

(Mohit et al., 2006)
dorsal-ventral compartment boundary of the wing disc | restricted | ventral to

Comment: anterior compartment

(Mohit et al., 2006)
northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage -- adult stage
(Lefrere et al., 1990)
oogenesis & adult stage | female
ovary
(Lefrere et al., 1990)
Additional Descriptive Data

pAbp expression at embryonic stages 1-4 is localized to the posterior pole of the embryo.

(Lecuyer et al., 2007)

pAbp transcript is expressed in cells immediately dorsal to and ventral to the dorsal/ventral compartment boundary of the wing disc; expression is limited to the anterior compartment. No expression is observed in the haltere disc.

(Mohit et al., 2006)

pAbp transcripts are detected at all developmental stages on northern blots.

(Lefrere et al., 1990)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage | female
ovary
(Pisa et al., 2009)
adult stage
adult head
(Aradska et al., 2015)
day 7 of adulthood -- day 49 of adulthood
adult heart
(Cammarato et al., 2011)
Additional Descriptive Data

In early embryos, pAbp protein is noticeably enriched apically to the blastoderm nuclei even though large amounts of the protein are also present in the basal cytoplasm. It partially co-localizes with BicD in the early embryo.

(Vazquez-Pianzola et al., 2011)
Marker for
 
Subcellular Localization
CV Term
Evidence
References
part_of catalytic step 2 spliceosome
inferred from high throughput direct assay
(Herold et al., 2009)
located_in cytoplasm
inferred from direct assay
(Vazquez-Pianzola et al., 2011, Sigrist et al., 2000)
located_in cytosol
inferred from high throughput direct assay
(Lye et al., 2014)
located_in nucleus
inferred from high throughput direct assay
(Lee et al., 2014)
part_of precatalytic spliceosome
inferred from high throughput direct assay
(Herold et al., 2009)
part_of ribonucleoprotein complex
inferred from direct assay
(Nelson et al., 2007)
Expression Deduced from Reporters
Reporter: P{PTT-GA}pAbp37-2
Stage
Tissue/Position (including subcellular localization)
Reference
oogenesis stage S2 -- S10
oocyte | posterior

Comment: cortex

(Vazquez-Pianzola et al., 2011)
oogenesis stage S10
nurse cell
(Vazquez-Pianzola et al., 2011)
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\pAbp in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 14 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 15 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of pAbp
Transgenic constructs containing regulatory region of pAbp
Aberrations (Deficiencies and Duplications) ( 8 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
lethal, with Scer\GAL4GMR.PF
lethal, with Scer\GAL4insc-Mz1407
lethal, with Scer\GAL4ple.PF
lethal, with Scer\GAL4pnr-MD237
lethal | recessive
lethal - all die before end of larval stage, with Scer\GAL4Act5C.PI
lethal - all die before end of pupal stage, with Scer\GAL4GMR.PF
lethal - all die before end of pupal stage, with Scer\GAL4Tab2-201Y
lethal - all die during embryonic stage, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
lethal - all die during embryonic stage (with Df(2R)Pcl7B)
lethal - all die during larval stage, with Scer\GAL4Mef2.PR
viable
viable, with Scer\GAL4elav-C155
viable, with Scer\GAL4ey-OK107
viable, with Scer\GAL4tin.CΔ4
viable (with Df(2R)Pcl7B)
Sterility
Allele
female fertile (with Df(2R)Pcl7B)
female sterile, with Scer\GAL4VP16.otu
female sterile | germline clone
male sterile
male sterile (with Df(2R)Pcl7B)
male sterile (with pAbpEP310)
male sterile (with pAbpk10109)
Other Phenotypes
Allele
abnormal cell growth | dominant
abnormal cytokinesis
abnormal cytokinesis (with pAbpEY11561)
abnormal cytokinesis (with pAbpk10109)
abnormal locomotor behavior | heat sensitive
abnormal meiotic cell cycle
abnormal meiotic cell cycle (with Df(2R)Pcl7B)
abnormal meiotic cell cycle (with pAbpEP310)
abnormal meiotic cell cycle (with pAbpk10109)
abnormal neuroanatomy
abnormal neuroanatomy, with Scer\GAL4Mhc.PW
abnormal neuroanatomy (with Df(2R)Pcl7B)
abnormal neuroanatomy | larval stage
abnormal neuroanatomy | larval stage, with Scer\GAL4insc-Mz1407
abnormal neurophysiology
abnormal neurophysiology, with Scer\GAL4Mhc.PW
abnormal neurophysiology (with Df(2R)Pcl7B)
abnormal neurophysiology | dominant
abnormal neurophysiology | larval stage
increased cell number | spermatogenesis, with Scer\GAL4tj.PU
neoplasia | adult stage | male, with Scer\GAL4VP16.bam
short lived | heat sensitive, with Scer\GAL4tin.CΔ4
some die during embryonic stage (with Df(2R)Pcl7B)
some die during larval stage, with Scer\GAL4Act5C.PI
some die during pupal stage, with Scer\GAL4GMR.PF
some die during pupal stage, with Scer\GAL4Tab2-201Y
visible | dominant
Phenotype manifest in
Allele
bouton
bouton, with Scer\GAL4Mhc.PW
bouton (with Df(2R)Pcl7B)
bouton | increased number
centriole & spermatocyte (with Df(2R)Pcl7B)
centrosome & spermatocyte (with Df(2R)Pcl7B)
cyst progenitor cell | ectopic, with Scer\GAL4tj.PU
elongation stage spermatid (with pAbpEY11561)
elongation stage spermatid (with pAbpk10109)
embryonic/larval neuromuscular junction
ganglion mother cell | larval stage, with Scer\GAL4insc-Mz1407
larval multidendritic class IV neuron | somatic clone, with Scer\GAL4Act.PU
larval neuroblast | larval stage, with Scer\GAL4insc-Mz1407
meiotic cell cycle
meiotic metaphase I
mitochondrion (with pAbpEY11561)
mitochondrion (with pAbpk10109)
Nebenkern (with pAbp5-SZ-4029)
Nebenkern (with pAbpEY11561)
Nebenkern (with pAbpk10109)
neuromuscular junction
neuromuscular junction, with Scer\GAL4Mhc.PW
neuromuscular junction (with Df(2R)Pcl7B)
neuromuscular junction | larval stage
NMJ bouton | larval stage
nucleus (with pAbpEY11561)
nucleus (with pAbpk10109)
onion stage spermatid (with Df(2R)Pcl7B)
onion stage spermatid (with pAbp5-SZ-4029)
onion stage spermatid (with pAbpEY11561)
onion stage spermatid (with pAbpk10109)
onion stage spermatid (with pAbpSH1908)
oocyte | germline clone | oogenesis stage S5
oocyte | germline clone | oogenesis stage S6
sarcomere, with Scer\GAL4Mef2.PR
spermatogonium, with Scer\GAL4VP16.bam
spindle & spermatocyte
spindle & spermatocyte (with Df(2R)Pcl7B)
spindle & spermatocyte (with pAbpEP310)
spindle & spermatocyte (with pAbpk10109)
testis, with Scer\GAL4VP16.bam
wing
Z disc, with Scer\GAL4Mef2.PR
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (102)
Hsap\PABPC4
13 of 14
Yes
Yes
1  
Hsap\PABPC1
12 of 14
No
Yes
2  
Hsap\PABPC3
12 of 14
No
Yes
1  
Hsap\PABPC1L
11 of 14
No
Yes
Hsap\PABPC4L
7 of 14
No
Yes
Hsap\PABPC5
5 of 14
No
Yes
Hsap\PABPC1L2A
4 of 14
No
Yes
Hsap\PABPC1L2B
4 of 14
No
Yes
Hsap\NCL
2 of 14
No
Yes
Hsap\A1CF
1 of 14
No
No
Hsap\BOLL
1 of 14
No
No
2  
Hsap\CELF1
1 of 14
No
No
3  
Hsap\CELF2
1 of 14
No
No
Hsap\CELF3
1 of 14
No
No
Hsap\CELF4
1 of 14
No
No
Hsap\CELF5
1 of 14
No
No
1  
Hsap\CELF6
1 of 14
No
No
Hsap\CSTF2
1 of 14
No
No
Hsap\DAZ1
1 of 14
No
No
Hsap\DAZ2
1 of 14
No
No
Hsap\DAZ3
1 of 14
No
No
Hsap\DAZ4
1 of 14
No
No
Hsap\DAZAP1
1 of 14
No
No
Hsap\DAZL
1 of 14
No
No
3  
Hsap\DND1
1 of 14
No
No
Hsap\ELAVL1
1 of 14
No
No
3  
Hsap\ELAVL2
1 of 14
No
No
2  
Hsap\ELAVL3
1 of 14
No
No
3  
Hsap\ELAVL4
1 of 14
No
No
2  
Hsap\HNRNPA0
1 of 14
No
No
Hsap\HNRNPA1
1 of 14
No
No
5  
Hsap\HNRNPA1L2
1 of 14
No
No
Hsap\HNRNPA2B1
1 of 14
No
No
13  
Hsap\HNRNPA3
1 of 14
No
No
2  
Hsap\HNRNPAB
1 of 14
No
No
Hsap\HNRNPC
1 of 14
No
No
1  
Hsap\HNRNPCL1
1 of 14
No
No
Hsap\HNRNPCL3
1 of 14
No
No
Hsap\HNRNPCL4
1 of 14
No
No
Hsap\HNRNPD
1 of 14
No
No
Hsap\HNRNPM
1 of 14
No
No
Hsap\HNRNPR
1 of 14
No
No
1  
Hsap\MSI1
1 of 14
No
No
1  
Hsap\MSI2
1 of 14
No
No
1  
Hsap\MYEF2
1 of 14
No
No
Hsap\NCBP2
1 of 14
No
No
Hsap\NONO
1 of 14
No
No
4  
Hsap\PSPC1
1 of 14
No
No
1  
Hsap\PUF60
1 of 14
No
No
Hsap\RALY
1 of 14
No
No
Hsap\RALYL
1 of 14
No
No
Hsap\RAVER1
1 of 14
No
Yes
Hsap\RAVER2
1 of 14
No
No
Hsap\RBFOX1
1 of 14
No
No
2  
Hsap\RBFOX2
1 of 14
No
No
Hsap\RBFOX3
1 of 14
No
No
Hsap\RBM4B
1 of 14
No
No
Hsap\RBM4
1 of 14
No
No
1  
Hsap\RBM7
1 of 14
No
No
Hsap\RBM11
1 of 14
No
No
Hsap\RBM14
1 of 14
No
No
Hsap\RBM14-RBM4
1 of 14
No
No
Hsap\RBM15B
1 of 14
No
No
Hsap\RBM18
1 of 14
No
No
1  
Hsap\RBM19
1 of 14
No
No
1  
Hsap\RBM22
1 of 14
No
No
Hsap\RBM23
1 of 14
No
No
Hsap\RBM28
1 of 14
No
No
1  
Hsap\RBM34
1 of 14
No
No
Hsap\RBM38
1 of 14
No
No
Hsap\RBM39
1 of 14
No
No
Hsap\RBM42
1 of 14
No
No
Hsap\RBM45
1 of 14
No
No
Hsap\RBM46
1 of 14
No
No
Hsap\RBM47
1 of 14
No
No
1  
Hsap\RBMS1
1 of 14
No
No
Hsap\RBMS2
1 of 14
No
No
1  
Hsap\RBMS3
1 of 14
No
No
Hsap\RBMY1A1
1 of 14
No
No
Hsap\RBMY1B
1 of 14
No
No
Hsap\RBMY1C
1 of 14
No
Yes
Hsap\RBMY1D
1 of 14
No
No
Hsap\RBMY1E
1 of 14
No
Yes
Hsap\RBMY1F
1 of 14
No
Yes
Hsap\RBMY1J
1 of 14
No
No
Hsap\REXO5
1 of 14
No
No
Hsap\SAFB2
1 of 14
No
No
1  
Hsap\SAFB
1 of 14
No
No
1  
Hsap\SART3
1 of 14
No
No
Hsap\SF3B4
1 of 14
No
No
Hsap\SFPQ
1 of 14
No
No
3  
Hsap\SREK1
1 of 14
No
No
1  
Hsap\SRSF1
1 of 14
No
No
20  
Hsap\SRSF4
1 of 14
No
No
1  
Hsap\SRSF5
1 of 14
No
No
1  
Hsap\SRSF6
1 of 14
No
No
1  
Hsap\SRSF9
1 of 14
No
No
1  
Hsap\SYNCRIP
1 of 14
No
No
1  
Hsap\TIA1
1 of 14
No
No
Hsap\TIAL1
1 of 14
No
No
1  
Hsap\TRNAU1AP
1 of 14
No
No
1  
Hsap\U2AF2
1 of 14
No
No
4  
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (67)
Rnor\Pabpc4
13 of 14
Yes
Yes
Rnor\Pabpc1
12 of 14
No
Yes
Rnor\Pabpc2
12 of 14
No
Yes
Rnor\Pabpc6
12 of 14
No
Yes
Rnor\Pabpc1l
9 of 14
No
Yes
Rnor\Pabpc4l
7 of 14
No
Yes
Rnor\Pabpc5
5 of 14
No
Yes
Rnor\Ncl
2 of 14
No
Yes
Rnor\Raver1
2 of 14
No
Yes
Rnor\A1cf
1 of 14
No
No
Rnor\Boll
1 of 14
No
No
Rnor\Celf1
1 of 14
No
No
Rnor\Celf2
1 of 14
No
No
Rnor\Celf3
1 of 14
No
No
Rnor\Celf4
1 of 14
No
No
Rnor\Celf5
1 of 14
No
No
Rnor\Celf6
1 of 14
No
No
Rnor\Cstf2
1 of 14
No
No
Rnor\Dazap1
1 of 14
No
No
Rnor\Dazl
1 of 14
No
No
Rnor\Dnd1
1 of 14
No
No
Rnor\Elavl1
1 of 14
No
No
Rnor\Elavl2
1 of 14
No
No
Rnor\Elavl3
1 of 14
No
No
Rnor\Elavl4
1 of 14
No
No
Rnor\Hnrnpa2b1
1 of 14
No
No
Rnor\Hnrnpc
1 of 14
No
No
Rnor\Hnrnpm
1 of 14
No
No
Rnor\Hnrnpr
1 of 14
No
No
Rnor\LOC681410
1 of 14
No
No
Rnor\LOC100911361
1 of 14
No
No
Rnor\Msi1
1 of 14
No
No
Rnor\Msi2
1 of 14
No
No
Rnor\Myef2
1 of 14
No
No
Rnor\Nono
1 of 14
No
No
Rnor\Pabpc1l2a
1 of 14
No
Yes
Rnor\Pspc1
1 of 14
No
No
Rnor\Puf60
1 of 14
No
No
Rnor\Ralyl
1 of 14
No
No
Rnor\Raly
1 of 14
No
No
Rnor\Raver2
1 of 14
No
Yes
Rnor\Rbfox1
1 of 14
No
No
Rnor\Rbfox2
1 of 14
No
No
Rnor\Rbfox3
1 of 14
No
No
Rnor\Rbm4b
1 of 14
No
No
Rnor\Rbm11
1 of 14
No
No
Rnor\Rbm15b
1 of 14
No
No
Rnor\Rbm19
1 of 14
No
No
Rnor\Rbm28
1 of 14
No
No
Rnor\Rbm34
1 of 14
No
No
Rnor\Rbm39
1 of 14
No
No
Rnor\Rbm42
1 of 14
No
No
Rnor\Rbm45
1 of 14
No
No
Rnor\Rbm46
1 of 14
No
No
Rnor\Rbm47
1 of 14
No
No
Rnor\Rbms1
1 of 14
No
No
Rnor\Rbms2
1 of 14
No
No
Rnor\Rbms3
1 of 14
No
No
Rnor\RGD1562451
1 of 14
No
Yes
Rnor\Sart3
1 of 14
No
No
Rnor\Sf3b4
1 of 14
No
No
Rnor\Sfpq
1 of 14
No
No
Rnor\Syncrip
1 of 14
No
No
Rnor\Tardbp
1 of 14
No
No
Rnor\Tia1
1 of 14
No
No
Rnor\Tial1
1 of 14
No
No
Rnor\U2af2
1 of 14
No
No
Mus musculus (laboratory mouse) (66)
Mmus\Pabpc4
13 of 14
Yes
Yes
Mmus\Pabpc1
12 of 14
No
Yes
Mmus\Pabpc2
12 of 14
No
Yes
Mmus\Pabpc6
12 of 14
No
Yes
Mmus\Pabpc1l
9 of 14
No
Yes
Mmus\Pabpc4l
7 of 14
No
Yes
Mmus\Pabpc5
5 of 14
No
Yes
Mmus\Ncl
2 of 14
No
Yes
Mmus\Raver1
2 of 14
No
Yes
Mmus\A1cf
1 of 14
No
No
Mmus\Boll
1 of 14
No
No
Mmus\Celf1
1 of 14
No
No
Mmus\Celf2
1 of 14
No
No
Mmus\Celf3
1 of 14
No
No
Mmus\Celf4
1 of 14
No
No
Mmus\Celf5
1 of 14
No
No
Mmus\Celf6
1 of 14
No
No
Mmus\Cstf2
1 of 14
No
No
Mmus\Dazap1
1 of 14
No
No
Mmus\Dazl
1 of 14
No
No
Mmus\Dnd1
1 of 14
No
No
Mmus\Elavl1
1 of 14
No
No
Mmus\Elavl2
1 of 14
No
No
Mmus\Elavl3
1 of 14
No
No
Mmus\Elavl4
1 of 14
No
No
Mmus\Gm9833
1 of 14
No
No
Mmus\Hnrnpa0
1 of 14
No
No
Mmus\Hnrnpa2b1
1 of 14
No
No
Mmus\Hnrnpc
1 of 14
No
No
Mmus\Hnrnpm
1 of 14
No
No
Mmus\Hnrnpr
1 of 14
No
No
Mmus\Msi1
1 of 14
No
No
Mmus\Msi2
1 of 14
No
No
Mmus\Myef2
1 of 14
No
No
Mmus\Nono
1 of 14
No
No
Mmus\Pabpc1l2b
1 of 14
No
Yes
Mmus\Pspc1
1 of 14
No
No
Mmus\Puf60
1 of 14
No
No
Mmus\Ralyl
1 of 14
No
No
Mmus\Raly
1 of 14
No
No
Mmus\Raver2
1 of 14
No
No
Mmus\Rbfox1
1 of 14
No
No
Mmus\Rbfox2
1 of 14
No
No
Mmus\Rbfox3
1 of 14
No
No
Mmus\Rbm4b
1 of 14
No
No
Mmus\Rbm4
1 of 14
No
No
Mmus\Rbm7
1 of 14
No
No
Mmus\Rbm11
1 of 14
No
No
Mmus\Rbm15b
1 of 14
No
No
Mmus\Rbm19
1 of 14
No
No
Mmus\Rbm28
1 of 14
No
No
Mmus\Rbm39
1 of 14
No
No
Mmus\Rbm42
1 of 14
No
No
Mmus\Rbm45
1 of 14
No
No
Mmus\Rbm46
1 of 14
No
No
Mmus\Rbm47
1 of 14
No
No
Mmus\Rbms1
1 of 14
No
No
Mmus\Rbms2
1 of 14
No
No
Mmus\Rbms3
1 of 14
No
No
Mmus\Sart3
1 of 14
No
No
Mmus\Sf3b4
1 of 14
No
No
Mmus\Sfpq
1 of 14
No
No
Mmus\Syncrip
1 of 14
No
No
Mmus\Tia1
1 of 14
No
No
Mmus\Tial1
1 of 14
No
No
Mmus\U2af2
1 of 14
No
No
Xenopus tropicalis (Western clawed frog) (52)
Xtro\pabpc1l
10 of 13
Yes
Yes
Xtro\pabpc1
7 of 13
No
Yes
Xtro\pabpc4
7 of 13
No
Yes
Xtro\LOC100490872
2 of 13
No
Yes
Xtro\a1cf
1 of 13
No
No
Xtro\celf1
1 of 13
No
No
Xtro\celf2
1 of 13
No
No
Xtro\celf4
1 of 13
No
No
Xtro\celf5
1 of 13
No
No
Xtro\dazap1
1 of 13
No
No
Xtro\dazl
1 of 13
No
No
Xtro\dnd1
1 of 13
No
No
Xtro\elavl1
1 of 13
No
No
Xtro\elavl2
1 of 13
No
No
Xtro\elavl3
1 of 13
No
No
Xtro\elavl4
1 of 13
No
No
Xtro\hnrnpa1
1 of 13
No
No
Xtro\hnrnpa3
1 of 13
No
No
Xtro\hnrnpab
1 of 13
No
No
Xtro\hnrnpc
1 of 13
No
No
Xtro\hnrnpm
1 of 13
No
No
Xtro\mrps9
1 of 13
No
No
Xtro\msi1
1 of 13
No
No
Xtro\msi2
1 of 13
No
No
Xtro\ncoa4
1 of 13
No
No
Xtro\ndufs5
1 of 13
No
No
Xtro\nono
1 of 13
No
No
Xtro\ralyl
1 of 13
No
No
Xtro\raly
1 of 13
No
No
Xtro\raver1
1 of 13
No
Yes
Xtro\rbfox2
1 of 13
No
No
Xtro\rbm4b
1 of 13
No
No
Xtro\rbm15b
1 of 13
No
No
Xtro\rbm15
1 of 13
No
No
Xtro\rbm19
1 of 13
No
No
Xtro\rbm22
1 of 13
No
No
Xtro\rbm34
1 of 13
No
No
Xtro\rbm38
1 of 13
No
No
Xtro\rbm42
1 of 13
No
No
Xtro\rbm46
1 of 13
No
No
Xtro\rbm47
1 of 13
No
No
Xtro\sart3
1 of 13
No
No
Xtro\sf3b4
1 of 13
No
No
Xtro\sltm
1 of 13
No
No
Xtro\snrnp70
1 of 13
No
No
Xtro\snx15
1 of 13
No
No
Xtro\srek1
1 of 13
No
No
Xtro\srsf1
1 of 13
No
No
Xtro\srsf4
1 of 13
No
No
Xtro\srsf9
1 of 13
No
No
Xtro\tia1
1 of 13
No
No
Xtro\tram2
1 of 13
No
No
Danio rerio (Zebrafish) (78)
Drer\pabpc1a
12 of 14
Yes
Yes
Drer\pabpc4
12 of 14
Yes
Yes
Drer\pabpc1b
11 of 14
No
Yes
Drer\pabpc1l
11 of 14
No
Yes
Drer\raver1
2 of 14
No
Yes
Drer\raver2
2 of 14
No
Yes
Drer\a1cf
1 of 14
No
No
Drer\celf1
1 of 14
No
No
Drer\celf2
1 of 14
No
No
Drer\celf3a
1 of 14
No
No
Drer\celf3b
1 of 14
No
No
Drer\celf4
1 of 14
No
No
Drer\celf5a
1 of 14
No
No
Drer\celf5b
1 of 14
No
No
Drer\celf6
1 of 14
No
No
Drer\cstf2
1 of 14
No
No
Drer\dazap1
1 of 14
No
No
Drer\dnd1
1 of 14
No
No
Drer\elavl1a
1 of 14
No
No
Drer\elavl1b
1 of 14
No
No
Drer\elavl2
1 of 14
No
No
Drer\elavl3
1 of 14
No
No
Drer\elavl4
1 of 14
No
No
Drer\hnrnpa1a
1 of 14
No
No
Drer\hnrnpabb
1 of 14
No
No
Drer\hnrnpc
1 of 14
No
No
Drer\hnrnpm
1 of 14
No
No
Drer\hnrnpr
1 of 14
No
No
Drer\igf2bp3
1 of 14
No
No
Drer\LOC100333618
1 of 14
No
No
Drer\LOC110437789
1 of 14
No
Yes
Drer\msi2b
1 of 14
No
No
Drer\myef2
1 of 14
No
No
Drer\ncl
1 of 14
No
No
Drer\pspc1
1 of 14
No
No
Drer\puf60a
1 of 14
No
No
Drer\puf60b
1 of 14
No
No
Drer\raly
1 of 14
No
No
Drer\ralyl
1 of 14
No
No
Drer\rbfox1
1 of 14
No
No
Drer\rbfox1l
1 of 14
No
No
Drer\rbfox2
1 of 14
No
No
Drer\rbfox3a
1 of 14
No
No
Drer\rbfox3b
1 of 14
No
No
Drer\rbm4.1
1 of 14
No
No
Drer\rbm4.2
1 of 14
No
No
Drer\rbm7
1 of 14
No
No
Drer\rbm11
1 of 14
No
No
Drer\rbm14a
1 of 14
No
No
Drer\rbm14b
1 of 14
No
No
Drer\rbm15b
1 of 14
No
No
Drer\rbm19
1 of 14
No
No
Drer\rbm28
1 of 14
No
No
Drer\rbm34
1 of 14
No
No
Drer\rbm39a
1 of 14
No
No
Drer\rbm39b
1 of 14
No
No
Drer\rbm42
1 of 14
No
No
Drer\rbm46
1 of 14
No
No
Drer\rbm47
1 of 14
No
No
Drer\rbms1a
1 of 14
No
No
Drer\rbms2a
1 of 14
No
No
Drer\rbms2b
1 of 14
No
No
Drer\rbms3
1 of 14
No
No
Drer\safb
1 of 14
No
No
Drer\sart3
1 of 14
No
No
Drer\sf3b4
1 of 14
No
No
Drer\si:ch73-190f9.4
1 of 14
No
Yes
Drer\srsf7b
1 of 14
No
No
Drer\syncrip
1 of 14
No
No
Drer\syncripl
1 of 14
No
No
Drer\tardbpb
1 of 14
No
No
Drer\tia1
1 of 14
No
No
Drer\tia1l
1 of 14
No
No
Drer\tial1
1 of 14
No
No
Drer\u2af2a
1 of 14
No
No
Drer\u2af2b
1 of 14
No
No
Drer\zgc:55733
1 of 14
No
No
Drer\zgc:165603
1 of 14
No
No
Caenorhabditis elegans (Nematode, roundworm) (39)
Cele\pab-1
11 of 14
Yes
Yes
Cele\pab-2
11 of 14
Yes
Yes
Cele\cpf-2
1 of 14
No
No
Cele\daz-1
1 of 14
No
No
Cele\etr-1
1 of 14
No
No
Cele\exc-7
1 of 14
No
No
Cele\F37D6.3
1 of 14
No
Yes
Cele\fox-1
1 of 14
No
No
Cele\hrpa-1
1 of 14
No
No
Cele\hrpa-2
1 of 14
No
No
Cele\hrpr-1
1 of 14
No
No
Cele\msi-1
1 of 14
No
No
Cele\nono-1
1 of 14
No
No
Cele\rbd-1
1 of 14
No
No
Cele\rbm-3.1
1 of 14
No
No
Cele\rbm-7
1 of 14
No
No
Cele\rbm-28
1 of 14
No
No
Cele\rbm-34
1 of 14
No
No
Cele\rbm-39
1 of 14
No
No
Cele\rbm-42
1 of 14
No
No
Cele\rnp-6
1 of 14
No
No
Cele\rnp-7
1 of 14
No
No
Cele\rnp-9
1 of 14
No
No
Cele\rsp-1
1 of 14
No
No
Cele\rsp-2
1 of 14
No
No
Cele\rsp-3
1 of 14
No
No
Cele\rsp-7
1 of 14
No
No
Cele\sap-49
1 of 14
No
No
Cele\sart-3
1 of 14
No
No
Cele\spn-4
1 of 14
No
No
Cele\sqd-1
1 of 14
No
No
Cele\sup-26
1 of 14
No
No
Cele\sup-46
1 of 14
No
No
Cele\tiar-1
1 of 14
No
No
Cele\tiar-2
1 of 14
No
No
Cele\uaf-1
1 of 14
No
No
Cele\unc-75
1 of 14
No
No
Cele\ZK616.1
1 of 14
No
Yes
Cele\ZK616.61
1 of 14
No
Yes
Anopheles gambiae (African malaria mosquito) (56)
Agam\AgaP_AGAP011092
12 of 12
Yes
Yes
Agam\AgaP_AGAP000916
2 of 12
No
Yes
Agam\AgaP_AGAP001640
2 of 12
No
Yes
Agam\AgaP_AGAP001643
2 of 12
No
Yes
Agam\AgaP_AGAP002655
2 of 12
No
Yes
Agam\AgaP_AGAP011091
2 of 12
No
Yes
Agam\AgaP_AGAP012564
2 of 12
No
Yes
Agam\AgaP_AGAP012675
2 of 12
No
Yes
Agam\AgaP_AGAP013051
2 of 12
No
Yes
Agam\AgaP_AGAP000917
1 of 12
No
Yes
Agam\AgaP_AGAP000918
1 of 12
No
Yes
Agam\AgaP_AGAP000919
1 of 12
No
Yes
Agam\AgaP_AGAP000920
1 of 12
No
Yes
Agam\AgaP_AGAP000921
1 of 12
No
Yes
Agam\AgaP_AGAP000965
1 of 12
No
No
Agam\AgaP_AGAP001419
1 of 12
No
No
Agam\AgaP_AGAP001460
1 of 12
No
No
Agam\AgaP_AGAP001538
1 of 12
No
No
Agam\AgaP_AGAP001883
1 of 12
No
No
Agam\AgaP_AGAP001930
1 of 12
No
No
Agam\AgaP_AGAP001993
1 of 12
No
No
Agam\AgaP_AGAP002256
1 of 12
No
No
Agam\AgaP_AGAP002335
1 of 12
No
No
Agam\AgaP_AGAP002374
1 of 12
No
No
Agam\AgaP_AGAP002390
1 of 12
No
No
Agam\AgaP_AGAP002654
1 of 12
No
Yes
Agam\AgaP_AGAP002908
1 of 12
No
No
Agam\AgaP_AGAP003171
1 of 12
No
No
Agam\AgaP_AGAP003173
1 of 12
No
No
Agam\AgaP_AGAP003794
1 of 12
No
No
Agam\AgaP_AGAP003899
1 of 12
No
No
Agam\AgaP_AGAP004592
1 of 12
No
No
Agam\AgaP_AGAP004950
1 of 12
No
No
Agam\AgaP_AGAP005127
1 of 12
No
No
Agam\AgaP_AGAP005249
1 of 12
No
No
Agam\AgaP_AGAP005292
1 of 12
No
No
Agam\AgaP_AGAP005505
1 of 12
No
No
Agam\AgaP_AGAP005506
1 of 12
No
No
Agam\AgaP_AGAP005964
1 of 12
No
No
Agam\AgaP_AGAP006089
1 of 12
No
No
Agam\AgaP_AGAP007325
1 of 12
No
No
Agam\AgaP_AGAP008433
1 of 12
No
No
Agam\AgaP_AGAP009477
1 of 12
No
No
Agam\AgaP_AGAP009952
1 of 12
No
No
Agam\AgaP_AGAP010200
1 of 12
No
No
Agam\AgaP_AGAP010495
1 of 12
No
No
Agam\AgaP_AGAP010496
1 of 12
No
No
Agam\AgaP_AGAP010553
1 of 12
No
No
Agam\AgaP_AGAP010918
1 of 12
No
No
Agam\AgaP_AGAP011884
1 of 12
No
No
Agam\AgaP_AGAP012137
1 of 12
No
No
Agam\AgaP_AGAP012250
1 of 12
No
No
Agam\AgaP_AGAP012503
1 of 12
No
No
Agam\AgaP_AGAP012853
1 of 12
No
No
Agam\AgaP_AGAP013048
1 of 12
No
No
Agam\NCBP2_ANOGA
1 of 12
No
No
Arabidopsis thaliana (thale-cress) (118)
Atha\PAB3
13 of 13
Yes
Yes
Atha\PAB5
13 of 13
Yes
Yes
Atha\PAB2
12 of 13
No
Yes
Atha\PAB4
12 of 13
No
Yes
Atha\PAB8
12 of 13
No
Yes
Atha\PAB1
5 of 13
No
Yes
Atha\PAB6
4 of 13
No
Yes
Atha\PAB7
3 of 13
No
Yes
Atha\AT1G45100
2 of 13
No
No
Atha\AT2G15500
2 of 13
No
Yes
Atha\AT3G10845
2 of 13
No
Yes
Atha\AT3G48840
2 of 13
No
Yes
Atha\AT5G03580
2 of 13
No
Yes
Atha\AT5G41690
2 of 13
No
Yes
Atha\MPC
2 of 13
No
Yes
Atha\AT1G01080
1 of 13
No
No
Atha\AT1G03457
1 of 13
No
No
Atha\AT1G17640
1 of 13
No
No
Atha\AT1G20880
1 of 13
No
No
Atha\AT1G22330
1 of 13
No
No
Atha\AT1G60000
1 of 13
No
No
Atha\AT1G60900
1 of 13
No
No
Atha\AT1G69250
1 of 13
No
No
Atha\AT1G78260
1 of 13
No
No
Atha\AT2G16940
1 of 13
No
No
Atha\AT2G21440
1 of 13
No
No
Atha\AT2G33435
1 of 13
No
No
Atha\AT2G35410
1 of 13
No
No
Atha\AT2G37220
1 of 13
No
No
Atha\AT2G41060
1 of 13
No
No
Atha\AT2G44710
1 of 13
No
No
Atha\AT2G47310
1 of 13
No
No
Atha\AT3G04500
1 of 13
No
No
Atha\AT3G07810
1 of 13
No
No
Atha\AT3G13224
1 of 13
No
No
Atha\AT3G14100
1 of 13
No
No
Atha\AT3G19330
1 of 13
No
Yes
Atha\AT3G48830
1 of 13
No
No
Atha\AT3G48835
1 of 13
No
Yes
Atha\AT3G52660
1 of 13
No
No
Atha\AT4G09040
1 of 13
No
No
Atha\AT4G10110
1 of 13
No
No
Atha\AT4G12640
1 of 13
No
No
Atha\AT4G14300
1 of 13
No
No
Atha\AT4G19610
1 of 13
No
No
Atha\AT4G26650
1 of 13
No
No
Atha\AT4G36960
1 of 13
No
No
Atha\AT5G05720
1 of 13
No
No
Atha\AT5G06210
1 of 13
No
Yes
Atha\AT5G08695
1 of 13
No
No
Atha\AT5G09880
1 of 13
No
No
Atha\AT5G19350
1 of 13
No
No
Atha\AT5G28390
1 of 13
No
No
Atha\AT5G40490
1 of 13
No
No
Atha\AT5G46840
1 of 13
No
No
Atha\AT5G47620
1 of 13
No
No
Atha\AT5G51300
1 of 13
No
No
Atha\AT5G52545
1 of 13
No
No
Atha\AT5G55550
1 of 13
No
No
Atha\AT5G59865
1 of 13
No
No
Atha\AT5G65260
1 of 13
No
No
Atha\ATRBP45C
1 of 13
No
No
Atha\ATRZ-1A
1 of 13
No
No
Atha\ATU2AF65A
1 of 13
No
No
Atha\CID8
1 of 13
No
No
Atha\CID9
1 of 13
No
No
Atha\CID10
1 of 13
No
No
Atha\CID11
1 of 13
No
No
Atha\CID12
1 of 13
No
Yes
Atha\CID13
1 of 13
No
No
Atha\CP29
1 of 13
No
No
Atha\CP31B
1 of 13
No
No
Atha\CP33
1 of 13
No
No
Atha\EIF3G1
1 of 13
No
No
Atha\EIF3G2
1 of 13
No
No
Atha\EMB140
1 of 13
No
No
Atha\emb2444
1 of 13
No
No
Atha\FCA
1 of 13
No
No
Atha\FPA
1 of 13
No
No
Atha\GRP4
1 of 13
No
No
Atha\GR-RBP2
1 of 13
No
No
Atha\GR-RBP3
1 of 13
No
Yes
Atha\GR-RBP5
1 of 13
No
Yes
Atha\LIF2
1 of 13
No
No
Atha\ML2
1 of 13
No
No
Atha\ML3
1 of 13
No
Yes
Atha\ML5
1 of 13
No
Yes
Atha\NUC-L1
1 of 13
No
No
Atha\NUC-L2
1 of 13
No
No
Atha\PABN1
1 of 13
No
No
Atha\PHIP1
1 of 13
No
No
Atha\PSRP2
1 of 13
No
No
Atha\RBP1
1 of 13
No
No
Atha\RBP31
1 of 13
No
No
Atha\RBP45A
1 of 13
No
No
Atha\RBP45B
1 of 13
No
No
Atha\RBP47A
1 of 13
No
No
Atha\RBP47B
1 of 13
No
No
Atha\RBP47C'
1 of 13
No
No
Atha\RBP47C
1 of 13
No
No
Atha\RBP-DR1
1 of 13
No
No
Atha\RRC1
1 of 13
No
No
Atha\RS2Z32
1 of 13
No
No
Atha\RS31a
1 of 13
No
No
Atha\RS31
1 of 13
No
No
Atha\RS40
1 of 13
No
No
Atha\RS41
1 of 13
No
No
Atha\SC35
1 of 13
No
No
Atha\SR30
1 of 13
No
No
Atha\SR34a
1 of 13
No
No
Atha\SR34
1 of 13
No
No
Atha\SR34b
1 of 13
No
No
Atha\SR45
1 of 13
No
No
Atha\SUA
1 of 13
No
No
Atha\U1-70K
1 of 13
No
No
Atha\UBA2A
1 of 13
No
No
Atha\UBP1A
1 of 13
No
No
Atha\UBP1B
1 of 13
No
No
Saccharomyces cerevisiae (Brewer's yeast) (20)
Scer\PAB1
12 of 13
Yes
Yes
Scer\MIP6
3 of 13
No
Yes
Scer\PES4
3 of 13
No
Yes
Scer\GBP2
1 of 13
No
No
Scer\HRB1
1 of 13
No
No
Scer\HRP1
1 of 13
No
No
Scer\HSH49
1 of 13
No
No
Scer\MRD1
1 of 13
No
No
Scer\NAM8
1 of 13
No
No
Scer\NGR1
1 of 13
No
No
Scer\NOP4
1 of 13
No
No
Scer\NOP12
1 of 13
No
No
Scer\NOP15
1 of 13
No
No
Scer\NPL3
1 of 13
No
No
Scer\NSR1
1 of 13
No
Yes
Scer\PRP24
1 of 13
No
No
Scer\PUB1
1 of 13
No
No
Scer\RIE1
1 of 13
No
Yes
Scer\RRT5
1 of 13
No
Yes
Scer\SGN1
1 of 13
No
No
Schizosaccharomyces pombe (Fission yeast) (15)
Spom\pabp
11 of 12
Yes
Yes
Spom\crp79
1 of 12
No
Yes
Spom\gar2
1 of 12
No
No
Spom\prp2
1 of 12
No
No
Spom\rsd1
1 of 12
No
No
Spom\sap49
1 of 12
No
No
Spom\SPAC25G10.01
1 of 12
No
No
Spom\SPAC222.18
1 of 12
No
Yes
Spom\SPAC328.05
1 of 12
No
No
Spom\SPBC4F6.14
1 of 12
No
No
Spom\SPBC23E6.01c
1 of 12
No
No
Spom\SPBC1861.04c
1 of 12
No
No
Spom\SPBP22H7.02c
1 of 12
No
No
Spom\spo5
1 of 12
No
No
Spom\tcg1
1 of 12
No
Yes
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:pAbp. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (50)
CG4612
7 of 13
shep
3 of 13
Spx
3 of 13
ssx
3 of 13
bru1
2 of 13
bru2
2 of 13
bru3
2 of 13
CG4806
2 of 13
fne
2 of 13
hfp
2 of 13
lark
2 of 13
maca
2 of 13
Rbp9
2 of 13
Sxl
2 of 13
B52
1 of 13
bol
1 of 13
Caper
1 of 13
CG1316
1 of 13
CG2931
1 of 13
CG3335
1 of 13
CG7903
1 of 13
CG11454
1 of 13
CG14414
1 of 13
CG34354
1 of 13
CG42458
1 of 13
cocoon
1 of 13
elav
1 of 13
Hrb27C
1 of 13
Hrb87F
1 of 13
Hrb98DE
1 of 13
hyd
1 of 13
LS2
1 of 13
mod
1 of 13
msi
1 of 13
nito
1 of 13
nonA-l
1 of 13
nonA
1 of 13
Rb97D
1 of 13
Rbfox1
1 of 13
Rbp1-like
1 of 13
Rbp1
1 of 13
Rox8
1 of 13
rump
1 of 13
Secp43
1 of 13
SF2
1 of 13
spen
1 of 13
Syp
1 of 13
TBPH
1 of 13
trv
1 of 13
U2af50
1 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 3 )
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    PABPC4; poly(A) binding protein cytoplasmic 4
    13 of 14
    603407
         
        PABPC1; poly(A) binding protein cytoplasmic 1
        12 of 14
        604679
             
            PABPC3; poly(A) binding protein cytoplasmic 3
            12 of 14
            604680
                 
                PABPC1L; poly(A) binding protein cytoplasmic 1 like
                11 of 14
                621055
                  PABPC4L; poly(A) binding protein cytoplasmic 4 like
                  7 of 14
                      PABPC5; poly(A) binding protein cytoplasmic 5
                      5 of 14
                      300407
                          PABPC1L2A; poly(A) binding protein cytoplasmic 1 like 2A
                          4 of 14
                              PABPC1L2B; poly(A) binding protein cytoplasmic 1 like 2B
                              4 of 14
                                  Functional Complementation Data
                                  Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
                                  Interactions
                                  Summary of Physical Interactions
                                  Interaction Browsers
                                  View in FlyBase Interactions Browser   View in MIST tool (external link)
                                  Please see the Physical Interaction reports below for full details
                                  protein-protein
                                  Physical Interaction
                                  Assay
                                  References
                                  pAbp - Atx2
                                  anti tag coimmunoprecipitation, western blot, cosedimentation through density gradient, anti bait coimmunoprecipitation
                                  (Petrauskas et al., 2024, Lee et al., 2017, Lim and Allada, 2013, Satterfield and Pallanck, 2006)
                                  pAbp - BicC
                                  anti tag coimmunoprecipitation, western blot
                                  (Kugler et al., 2009)
                                  pAbp - BicD
                                  anti bait coimmunoprecipitation, western blot, Identification by mass spectrometry
                                  (Vazquez-Pianzola et al., 2011)
                                  pAbp - Cnot4
                                  anti tag coimmunoprecipitation, anti tag western blot
                                  (Zekri et al., 2009)
                                  pAbp - Fmr1
                                  anti bait coimmunoprecipitation, western blot, Identification by mass spectrometry
                                  (Zhang et al., 2022)
                                  pAbp - Hrb27C
                                  anti bait coimmunoprecipitation, western blot
                                  (Clouse et al., 2008)
                                  pAbp - Lsm12a
                                  anti tag coimmunoprecipitation, western blot
                                  (Lee et al., 2017)
                                  pAbp - Mettl3
                                  anti tag coimmunoprecipitation, anti tag western blot
                                  (Tang et al., 2021)
                                  pAbp - Mkrn1
                                  anti bait coimmunoprecipitation, anti tag western blot, anti tag coimmunoprecipitation, Identification by mass spectrometry, western blot
                                  (Dold et al., 2020)
                                  pAbp - Not3
                                  anti tag coimmunoprecipitation, anti tag western blot
                                  (Zekri et al., 2009)
                                  pAbp - Paip2
                                  pull down, western blot, anti bait coimmunoprecipitation, molecular weight estimation by coomasie staining, anti tag coimmunoprecipitation, anti tag western blot, far western blotting, autoradiography
                                  (Kachaev et al., 2018, Duncan et al., 2009, Roy et al., 2004)
                                  pAbp - Pdcd4
                                  pull down, western blot
                                  (Fehler et al., 2015)
                                  pAbp - Rga
                                  anti tag coimmunoprecipitation, anti tag western blot
                                  (Zekri et al., 2009)
                                  pAbp - RpL10Ab
                                  pull down, western blot
                                  (Antic et al., 2015)
                                  pAbp - Unr
                                  light scattering, pull down, western blot, anti bait coimmunoprecipitation, nuclear magnetic resonance, x-ray crystallography
                                  (Hollmann et al., 2023, Duncan et al., 2009)
                                  pAbp - aub
                                  cosedimentation through density gradient, western blot, anti tag coimmunoprecipitation, Identification by mass spectrometry, anti tag western blot, pull down, affinity technology, tag visualisation by luciferase assay, anti bait coimmunoprecipitation
                                  (Ramat et al., 2020, Ma et al., 2017)
                                  pAbp - cup
                                  anti bait coimmunoprecipitation, western blot, Identification by mass spectrometry
                                  (Wang et al., 2017, Clouse et al., 2008)
                                  pAbp - eIF4E1
                                  anti bait coimmunoprecipitation, Identification by mass spectrometry, western blot, anti tag coimmunoprecipitation
                                  (Wang et al., 2017, Lim et al., 2011)
                                  pAbp - eIF4G1
                                  anti tag coimmunoprecipitation, anti tag western blot, anti bait coimmunoprecipitation, Identification by mass spectrometry, western blot
                                  (Wang et al., 2017, Ghosh and Lasko, 2015, Zekri et al., 2009)
                                  pAbp - eIF4G2
                                  anti bait coimmunoprecipitation, western blot
                                  (Ghosh and Lasko, 2015)
                                  pAbp - fl(2)d
                                  anti tag coimmunoprecipitation, anti tag western blot
                                  (Tang et al., 2021)
                                  pAbp - gw
                                  pull down, molecular weight estimation by staining, anti tag western blot, anti tag coimmunoprecipitation
                                  (Huntzinger et al., 2013, Fukaya and Tomari, 2011, Huntzinger et al., 2010, Zekri et al., 2009)
                                  pAbp - larp
                                  anti tag coimmunoprecipitation, peptide massfingerprinting
                                  (Blagden et al., 2009)
                                  pAbp - me31B
                                  anti tag coimmunoprecipitation, western blot, anti bait coimmunoprecipitation, Identification by mass spectrometry
                                  (Lee et al., 2017, Wang et al., 2017)
                                  pAbp - nito
                                  anti tag coimmunoprecipitation, anti tag western blot
                                  (Tang et al., 2021)
                                  pAbp - orb
                                  anti bait coimmunoprecipitation, western blot
                                  (Wong et al., 2011)
                                  pAbp - osk
                                  anti tag coimmunoprecipitation, Identification by mass spectrometry, electrophoretic mobility shift assay, autoradiography, pull down, western blot
                                  (Tanaka et al., 2021, Vazquez-Pianzola et al., 2011)
                                  pAbp - pum
                                  pull down, anti tag western blot
                                  (Weidmann et al., 2014)
                                  pAbp - shep
                                  anti tag coimmunoprecipitation, Identification by mass spectrometry
                                  (Olesnicky et al., 2018)
                                  pAbp - sqd
                                  anti tag coimmunoprecipitation, western blot, anti bait coimmunoprecipitation, peptide massfingerprinting
                                  (Clouse et al., 2008)
                                  pAbp - tral
                                  anti bait coimmunoprecipitation, Identification by mass spectrometry, western blot
                                  (Wang et al., 2017, Wilhelm et al., 2005)
                                  pAbp - twin
                                  anti tag coimmunoprecipitation, anti tag western blot
                                  (Zekri et al., 2009)
                                  pAbp - tyf
                                  anti tag coimmunoprecipitation, peptide massfingerprinting, western blot, anti bait coimmunoprecipitation, pull down, autoradiography
                                  (Lee et al., 2017, Lim and Allada, 2013, Zhang et al., 2013, Lim et al., 2011)
                                  pAbp - vas
                                  anti tag coimmunoprecipitation, Identification by mass spectrometry, western blot
                                  (Durdevic and Ephrussi, 2019)
                                  RNA-protein
                                  Physical Interaction
                                  Assay
                                  References
                                  pAbp - Dscam1
                                  pull down, anti tag western blot
                                  (Singh et al., 2022)
                                  pAbp - Hsp83
                                  nucleic acid uv cross-linking assay, autoradiography
                                  (Nelson et al., 2007)
                                  pAbp - Imp
                                  electrophoretic mobility shift assay, autoradiography
                                  (Hansen et al., 2015)
                                  pAbp - Mi-2
                                  anti tag coimmunoprecipitation, quantitative reverse transcription pcr, iclip, partial RNA sequence identification
                                  (Ullah et al., 2022)
                                  pAbp - Ubx
                                  anti tag coimmunoprecipitation, quantitative reverse transcription pcr, nucleic acid uv cross-linking assay, fluorescent dye label, fluorescence technology
                                  (Blanco et al., 2025, Carnesecchi et al., 2022)
                                  pAbp - fne
                                  anti tag coimmunoprecipitation, quantitative reverse transcription pcr
                                  (Alizzi et al., 2020)
                                  pAbp - grk
                                  pull down, peptide massfingerprinting
                                  (McDermott et al., 2012)
                                  pAbp - hry
                                  pull down, western blot
                                  (Vazquez-Pianzola et al., 2011)
                                  pAbp - osk
                                  anti tag coimmunoprecipitation, Identification by mass spectrometry, electrophoretic mobility shift assay, autoradiography, pull down, western blot
                                  (Tanaka et al., 2021, Vazquez-Pianzola et al., 2011)
                                  Summary of Genetic Interactions
                                  Interaction Browsers
                                  View in FlyBase Interactions Browser   View in MIST tool (external link)
                                  Please look at the allele data for full details of the genetic interactions
                                  Starting gene(s)
                                  Interaction type
                                  Interacting gene(s)
                                  Reference
                                  pAbp
                                  enhanceable
                                  hyd
                                  (Pertceva et al., 2010)
                                  pAbp
                                  enhanceable
                                  larp
                                  (Blagden et al., 2009)
                                  pAbp
                                  enhanceable
                                  Paip2
                                  (Roy et al., 2004)
                                  Starting gene(s)
                                  Interaction type
                                  Interacting gene(s)
                                  Reference
                                  Atx2
                                  suppressible
                                  pAbp
                                  (Lessing and Bonini, 2008)
                                  BicD
                                  suppressible
                                  pAbp
                                  (Vazquez-Pianzola et al., 2011)
                                  eas
                                  suppressible
                                  pAbp
                                  (Hekmat-Scafe et al., 2005)
                                  Fmr1
                                  suppressible
                                  pAbp
                                  (Cziko et al., 2009)
                                  GluRIIA
                                  suppressible
                                  pAbp
                                  (Sigrist et al., 2002)
                                  hyd
                                  enhanceable
                                  pAbp
                                  (Pertceva et al., 2010)
                                  larp
                                  enhanceable
                                  pAbp
                                  (Blagden et al., 2009)
                                  Paip2
                                  suppressible
                                  pAbp
                                  (Roy et al., 2004)
                                  tut
                                  enhanceable
                                  pAbp
                                  (Shan et al., 2017)
                                  upd1
                                  suppressible
                                  pAbp
                                  (Mukherjee et al., 2006)
                                  External Data
                                  Subunit Structure (UniProtKB)
                                  Core component of the neuromuscular Atx2 complex, composed of at least Atx2, tyf, pAbp, Lsm12a (PubMed:28388438). Interacts with Atx2 (via PAM2 motif) (PubMed:28388438). Atx2 and pAbp form a subcomplex that can associate with the 5' cap of pre-mRNAs independently of tyf, Lsm12a or me31B (PubMed:28388438). Forms a ribonucleoprotein complex (RNP) containing at least me31B, eIF4E1, cup, tral and pAbp; this interaction is required for the translational silencing of maternal mRNAs during the maternal-to-zygotic transition (PubMed:28875934). In 1-5 hour embryos, interaction with me31B is severely reduced and there is no detected interaction with cup and tral, however interaction with eIF4E1 and eIF4G1 remains unchanged (PubMed:28875934). Interacts with gw; this interaction interferes with the binding of pAbp to eIF4G and is required for miRNA-mediated silencing (PubMed:19797087). Interacts with larp (PubMed:19631203). Interacts with Unr (PubMed:36688322).
                                  (UniProt, P21187 )
                                  Linkouts
                                  DroID - A comprehensive database of gene and protein interactions.
                                  MIST (genetic) - An integrated Molecular Interaction Database
                                  MIST (protein-protein) - An integrated Molecular Interaction Database
                                  Pathways
                                  Signaling Pathways (FlyBase)
                                  Metabolic Pathways
                                  FlyBase
                                  External Links
                                  External Data
                                  Linkouts
                                  KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
                                  Class of Gene
                                  Genomic Location and Detailed Mapping Data
                                  Chromosome (arm)
                                  2R
                                  Recombination map
                                  2-84
                                  Cytogenetic map
                                  55B8-55B9
                                  Sequence location
                                  FlyBase Computed Cytological Location
                                  Cytogenetic map
                                  Evidence for location
                                  55B8-55B9
                                  Left limit from in situ hybridisation (FBrf0157097) Right limit from in situ hybridisation (FBrf0157097)
                                  Experimentally Determined Cytological Location
                                  Cytogenetic map
                                  Notes
                                  References
                                  55B8-55B9
                                  (Oh et al., 2003)
                                  55B-55B
                                  (Lefrere, 1993)
                                  55B-55B
                                  (determined by in situ hybridisation)
                                  (Fasulo, 1999.9.15, Lefrere et al., 1990)
                                  55B5-55B6
                                  (determined by in situ hybridisation)
                                  (Spradling et al., 1999)
                                  55B5-55B6
                                  (BDGP Project Members, 1994-1999)
                                  Experimentally Determined Recombination Data
                                  Location

                                  2-84

                                  (FlyBase, 2016)

                                  2-88.7

                                  (Comeron et al., 2012)
                                  Left of (cM)
                                  Right of (cM)
                                  Notes
                                  Stocks and Reagents
                                  Stocks (24)
                                  Genomic Clones (21)
                                  cDNA Clones (908)
                                   

                                  Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

                                  cDNA clones, fully sequenced
                                  BDGP DGC clones
                                    Other clones
                                    Drosophila Genomics Resource Center cDNA clones

                                    For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                                    cDNA Clones, End Sequenced (ESTs)
                                    BDGP DGC clones
                                    Other clones
                                    RNAi and Array Information
                                    Linkouts
                                    Antibody Information
                                    Laboratory Generated Antibodies
                                     

                                    polyclonal

                                    (Zhang et al., 2022, Lee et al., 2017, Antic et al., 2015, Nishihara et al., 2013)

                                    monoclonal

                                    (Na et al., 2016)
                                    Commercially Available Antibodies
                                     
                                    Cell Line Information
                                    Publicly Available Cell Lines
                                     
                                      Other Stable Cell Lines
                                       
                                        Other Comments

                                        RNAi generated by PCR using primers directed to this gene causes a cell growth and viability phenotype when assayed in Kc167 and S2R+ cells.

                                        (Boutros et al., 2004)

                                        3 alleles of l(2)SH1908 recovered in a P-insertion screen.

                                        (Oh et al., 2003)

                                        pAbp is required to connect the centrosome to the minus-ends of free microtubules.

                                        (Fasulo et al., 1999)

                                        Annotation CG16803 eliminated in the July 2000 Celera release of annotated sequence.

                                        (FlyBase, 1996-)

                                        A sequence comparison and numerical analysis of the RRM-containing (RNA recognition motif) proteins suggests that functionally related RRM-containing proteins have significant sequence similarities in their RRMs.

                                        (Kim and Baker, 1993)

                                        Isolated from a 3-12 hour embryo cDNA library using a human PABP cDNA probe.

                                        (Lefrere et al., 1990)

                                        A pAbp cDNA has been cloned and sequenced.

                                        (Lefrere et al., 1990)
                                        Relationship to Other Genes
                                        Source for database merge of

                                        Source for merge of: pAbp anon- EST:Posey247 anon- EST:Posey249

                                        (Ashburner, 2004.6.30)

                                        Source for merge of: pAbp l(2)k10109

                                        (Spradling et al., 1999)

                                        Source for merge of: pAbp l(2)SH1908

                                        (Blagden et al., 2009)

                                        Source for merge of: pAbp BcDNA:LD24412

                                        (FlyBase, 1996-)

                                        Source for merge of: CG16803 anon- EST:fe2E5

                                        (Bayraktaroglu, 2000.11.2)

                                        Source for merge of: pAbp CG16803

                                        (FlyBase Genome Annotators, 2012)
                                        Additional comments

                                        Annotation CG5119 and previously withdrawn annotation CG16803 merged in release 5.49 of the genome annotation; CG16803 corresponds to the 3' UTR of CG5119. Merge based on RNA-Seq expression data.

                                        (FlyBase Genome Annotators, 2012)

                                        Source for merge of pAbp BcDNA:LD24412 was a shared cDNA ( date:020730 ).

                                        (FlyBase, 1996-)
                                        Nomenclature History
                                        Source for database identify of

                                        Source for identity of: pAbp CG5119

                                        (Li, 1999.11)
                                        Nomenclature comments
                                        Etymology
                                        Synonyms and Secondary IDs (39)
                                        Reported As
                                        Symbol Synonym
                                        BABP
                                        (Buddika et al., 2021)
                                        BcDNA:LD24412
                                        CG16803
                                        (Mack et al., 2006)
                                        CG5119
                                        (Onishi et al., 2020, Kolkhof et al., 2017, Marygold et al., 2017, Meadows, 2017.9.14, Çiçek et al., 2016, Na et al., 2016, Horan et al., 2015, Hosono et al., 2015, DeSalvo et al., 2014, Costa et al., 2013, Hoffmann et al., 2013, Schertel et al., 2013, Yoshigi et al., 2013, Christis and Munro, 2012, Jaspers et al., 2012, Cammarato et al., 2011, Ni et al., 2011.7.19, Jäger and Dorner, 2010, Müller et al., 2010, Ni et al., 2010.12.1, Blagden et al., 2009, Herold et al., 2009, Mohammad et al., 2009, Perkins et al., 2009, Pisa et al., 2009, Worringer et al., 2009, Zekri et al., 2009, Clouse et al., 2008, Hughes et al., 2008, Behm-Ansmant et al., 2007, Cermelli et al., 2006, Mohit et al., 2006, Molnar et al., 2006, Huang et al., 2005, Ashburner, 2004.6.30, Huang et al., 2004, Ramet et al., 2002, Mount and Salz, 2000)
                                        PABP
                                        (Chen et al., 2024, Petrauskas et al., 2024, Pushpalatha et al., 2022, Buddika et al., 2021, Tanaka et al., 2021, Wang and Lin, 2021, Blatt et al., 2020, Obrdlik et al., 2019, Kachaev et al., 2018, Moschall et al., 2017, Rissland et al., 2017, Wang et al., 2017, Azlan et al., 2016, Tat et al., 2016, Eikenes et al., 2015, Fehler et al., 2015, Ghosh and Lasko, 2015, McGurk et al., 2015, Colin et al., 2014, Ghosh et al., 2014, Costa et al., 2013, Hernández et al., 2013, Lim and Allada, 2013, Nishihara et al., 2013, Zekri et al., 2013, Zhang et al., 2013, McDermott et al., 2012, Vazquez-Pianzola and Suter, 2012, Khong and Jan, 2011, Lim et al., 2011, Yao and Fox, 2011, Garrey et al., 2010, Blagden et al., 2009, Cziko et al., 2009, Duncan et al., 2009, Farny et al., 2009, Gouw et al., 2009, Herold et al., 2009, Kugler et al., 2009, Pisa et al., 2009, Snee and Macdonald, 2009, Worringer et al., 2009, Clouse et al., 2008, Duncan, 2008, Lessing and Bonini, 2008, Nelson et al., 2007, Wong et al., 2007, Wilhelm et al., 2005, Yang et al., 2005, Luschnig and Krasnow, 2003, Volohonsky and Volk, 2003, Darnell, 2002, Glenn and Searles, 2001, Johnstone and Lasko, 2001, DiAntonio, 2000, Schuster et al., 2000, Lie and Macdonald, 1999, Schuster et al., 1999, Sigrist et al., 1999, Lefrere and Duncan, 1994, Lonie et al., 1994, Fukami-Kobayashi et al., 1993, Kim and Baker, 1993, Lefrere, 1993, Matunis et al., 1992, Lefrere et al., 1990)
                                        PABP55
                                        (Bayer et al., 2024)
                                        PABP55B
                                        (Vazquez-Pianzola et al., 2011, Clouse et al., 2008)
                                        PABPC1
                                        (Horan et al., 2015, Collart and Panasenko, 2012, Vazquez-Pianzola et al., 2011, Huntzinger et al., 2010, Jäger and Dorner, 2010, Zekri et al., 2009, Behm-Ansmant et al., 2007)
                                        PAbp
                                        (Berry et al., 2022, Mount and Salz, 2000)
                                        Pabp
                                        (Kamiyama and Niwa, 2022, Wong et al., 2011, Andersen et al., 2010, Gan et al., 2010, Roy et al., 2004)
                                        anon-EST:Posey247
                                        anon-EST:Posey249
                                        anon-EST:fe2E5
                                        dPABP
                                        (Kim et al., 2014, Gareau et al., 2013, Garrey et al., 2010, Satterfield and Pallanck, 2006, Yang et al., 2004, Roy et al., 2001)
                                        duo
                                        (Fasulo et al., 1999)
                                        l(2)SH1908
                                        (Blagden et al., 2009)
                                        l(2)SH2 1908
                                        (Oh et al., 2002.3.26)
                                        l(2)k10109
                                        (BDGP Project Members, 1994-1999)
                                        pAB
                                        (Graham et al., 2001)
                                        pABP
                                        (Hader et al., 2003)
                                        pABp
                                        (Lindström et al., 2017, McGurk et al., 2015)
                                        pAbp
                                        (Blanco et al., 2025, Hollmann et al., 2023, Perlegos et al., 2023, Pianzola and Suter, 2023.1.31, Karki et al., 2022, Kong et al., 2022, Ribot et al., 2022, Singh et al., 2022, Ullah et al., 2022, Zhang et al., 2022, Kim et al., 2021, Pang et al., 2021, Zuko et al., 2021, Dold et al., 2020, Jin et al., 2020, Lasko, 2020, Fingerhut et al., 2019, Anderson et al., 2018, Gene Disruption Project members, 2018-, Housden et al., 2017, Kristó et al., 2017, Ma et al., 2017, Marygold et al., 2017, Shan et al., 2017, Transgenic RNAi Project members, 2017-, Lee et al., 2016, Lefebvre et al., 2016, Na et al., 2016, Zhang et al., 2016, Angrisani et al., 2015, Chartier et al., 2015, Dent et al., 2015, Hansen et al., 2015, Horan et al., 2015, Kavi et al., 2015, Liu and Lasko, 2015, Ashwal-Fluss et al., 2014, Lee et al., 2014, Mukherjee et al., 2014, Weidmann et al., 2014, Kwon et al., 2013, O'Sullivan et al., 2013, Schertel et al., 2013, Yoshigi et al., 2013, Zhu et al., 2013, FlyBase Genome Annotators, 2012, Franco et al., 2011, Friedman et al., 2011, Lindquist et al., 2011, Neumüller et al., 2011, Schrider et al., 2011, Singh et al., 2011, Blanco et al., 2010, Müller et al., 2010, Parry et al., 2010, Pertceva et al., 2010, Temme et al., 2010, Blagden et al., 2009, Fisher et al., 2008, Lecuyer et al., 2007, Marygold et al., 2007, Stuart et al., 2007, Cermelli et al., 2006, Mohit et al., 2006, Molnar et al., 2006, Mukherjee et al., 2006)
                                        pabp
                                        (de Queiroz et al., 2025, Buddika et al., 2020, Vazquez-Pianzola and Suter, 2012, Vazquez-Pianzola et al., 2011, Lessing and Bonini, 2008, Sofola et al., 2007, Sigrist et al., 2003, Reiff et al., 2002, Sigrist et al., 2002, Sigrist et al., 2000)
                                        Name Synonyms
                                        Poly(A) Binding Protein
                                        (Costa et al., 2013)
                                        Poly(A) binding protein
                                        (Pisa et al., 2009)
                                        Poly(A)-binding protein
                                        (Costa et al., 2013, Vazquez-Pianzola et al., 2011)
                                        Poly(A)binding protein
                                        (Temme et al., 2010)
                                        PolyA-binding protein
                                        (Rangone et al., 2024, Nakayama et al., 2014)
                                        Polyadenylate-binding protein
                                        (Urban et al., 2017)
                                        anon-fast-evolving-2E5
                                        cytoplasmic poly-A binding protein
                                        (Ghanim et al., 2020)
                                        doppio fuso
                                        (Fasulo et al., 1999)
                                        lethal (2) SH1908
                                        poly (A)-binding protein
                                        (Mukherjee et al., 2006)
                                        poly(A) binding protein
                                        (Yao and Fox, 2011, Snee and Macdonald, 2009)
                                        poly(A)-binding protein
                                        (Hernández et al., 2013, Vazquez-Pianzola and Suter, 2012, Yao and Fox, 2011, Blagden et al., 2009, Chang et al., 2008, Lessing and Bonini, 2008, Huang et al., 2004)
                                        poly-A binding protein
                                        (Cziko et al., 2009)
                                        polyA-binding protein
                                        (Hoffmann et al., 2013, Jaspers et al., 2012, Cammarato et al., 2011, Clouse et al., 2008, Cermelli et al., 2006)
                                        polyadenylate-binding protein
                                        (Zhang et al., 2013)
                                        Secondary FlyBase IDs
                                        • FBgn0261619
                                        • FBgn0003031
                                        • FBgn0021963
                                        • FBgn0027713
                                        • FBgn0027714
                                        • FBgn0063151
                                        • FBgn0065324
                                        • FBgn0025217
                                        • FBgn0040739
                                        Datasets (0)
                                        Study focus (0)
                                        Experimental Role
                                        Project
                                        Project Type
                                        Title
                                        Study result (0)
                                        Result
                                        Result Type
                                        Title
                                        External Crossreferences and Linkouts ( 67 )
                                        Sequence Crossreferences
                                        NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                                        GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                                        GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                                        RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                                        UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
                                        UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
                                        Other crossreferences
                                        AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
                                        BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
                                        DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
                                        EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
                                        FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
                                        InterPro - A database of protein families, domains and functional sites
                                        KEGG Genes - Molecular building blocks of life in the genomic space.
                                        MARRVEL_MODEL - MARRVEL (model organism gene)
                                        PDB - An information portal to biological macromolecular structures
                                        Linkouts
                                        Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                                        DroID - A comprehensive database of gene and protein interactions.
                                        Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                                        FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                                        FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                                        Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                                        FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
                                        iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                                        Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
                                        KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
                                        MIST (genetic) - An integrated Molecular Interaction Database
                                        MIST (protein-protein) - An integrated Molecular Interaction Database
                                        References (279)