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Gene Dmel\tn

General Information
Symbol	Dmel\tn	Species	D. melanogaster
Name	thin	Annotation symbol	CG15105
Feature type	protein_coding_gene	FlyBase ID	FBgn0265356
Gene Model Status	Current	Stock availability	10 publicly available
Also Known As	abba
Genomic Location
Chromosome (arm)	2R	Recombination map	2-85.6
Cytogenetic map	56A2-56B	Sequence location	2R:14,874,849..14,896,449 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene thin is referred to in FlyBase by the symbol Dmel\tn (CG15105, FBgn0265356). It is a protein_coding_gene from Drosophila melanogaster. An electronic pipeline based on InterPro domains suggests that it has the molecular function: zinc ion binding. There is experimental evidence that it is involved in the biological process: muscle fiber development; muscle cell homeostasis. 12 alleles are reported. No phenotypic data is available. It has 6 annotated transcripts and 6 annotated polypeptides. Protein features are: NHL repeat; NHL repeat, subgroup; Six-bladed beta-propeller, TolB-like; Zinc finger, C3HC4 RING-type; Zinc finger, RING-type; Zinc finger, RING/FYVE/PHD-type. Gene sequence location is 2R:14874849..14896449.
User Contributed Data
	Beta version, feedback welcome
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	tn: thin Fully penetrant recessive lethal (no homozygous adults recovered). Hatching occurs late and second/third instar moult is delayed. Third instar larvae are long, thin, and rather slow-moving; histological examination shows abnormal muscle structure. Puparium also long and thin. Pupal development of homozygotes incomplete. Since mutants are unable to perform movements necessary for pupation, they die prior to eclosion.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03	Controlled Vocabulary Terms molecular_function
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 56A2-56B   Limits computationally determined from genome sequence between P{lacW}prodk08810 and P{PZ}ena02029&P{lacW}corak08713; Left limit from non-inclusion within Df(2R)PC4 (citation unavailable) Right limit from complementation mapping against Tp(1;2)TE56Ba (citation unavailable)
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location	2-85.6
Left of (cM)	px
Right of (cM)	c
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\tn for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Low-frequency RNA-Seq exon junction(s) not annotated. Gene model reviewed during 5.50
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) tn-RA FBtr0086573  NM_137546   4536   1353 tn-RB FBtr0086572  NM_166318   4678   1353 tn-RC FBtr0114622  NM_001144235   5170   1517 tn-RD FBtr0340447     4668   1248 tn-RE FBtr0340448     4308   1277 tn-RF FBtr0340449     3182   827
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein tn-PA   FBpp0085757   145.6   1353   7.34     NP_611390   AAF57612 tn-PB   FBpp0085756   145.6   1353   7.34     NP_725843   AAF57611 tn-PC   FBpp0113114   164.3   1517   4.69     NP_001137707   ACL83161 tn-PD   FBpp0309389   134.2   1248   7.33       tn-PE   FBpp0309390   137.2   1277   7.23       tn-PF   FBpp0309391   90.1   827   7.75
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Zinc finger, RING-type (IPR001841) NHL repeat, subgroup (IPR013017) Six-bladed beta-propeller, TolB-like (IPR011042) Zinc finger, C3HC4 RING-type (IPR018957) NHL repeat (IPR001258) Zinc finger, RING/FYVE/PHD-type (IPR013083)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE013599 AAF57611   AE013599 AAF57612   AE013599 ACL83161   AI106668   AI293752   AI403374   AI403780   AI517254   AK283971   AW940241   AY121620 AAM51947   BG633231   BI166591   BI227754   BI241520   BI242350   BI358203   BI364518   BI615811   BI618318   BI621181   BI626112   CO188564   CO264642   CO266287   CO267703   CO270688   CO273411   CO289917   CO296556   CO296949   CO306549   CO307014   CO308299   CO308547   CO310208   CO318224   CZ485287   CZ485288   EC063107   EC066458   EC066762   EC071954   EC073249   EC075711   EC077474   EC080555   EC080633   EC086396   EC087496   EC087990   EC088028   EC089213   EC196404   EC214463   EC215034   EC215065   EC222097   EC227417   EC243208   EC250359   EC259591   EC259911   ES690120   ES697228
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q7JUV6 B7YZK8
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 13 -- 16   dorsal pharyngeal muscle   (Fisher et al., 2012) embryonic dorsal epidermis   (Fisher et al., 2012) embryonic ventral epidermis   (Fisher et al., 2012) embryonic/larval muscle system   (Fisher et al., 2012) embryonic/larval somatic muscle   (Fisher et al., 2012)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Z disc inferred from direct assay (Labeau-Dimenna et al., 2012)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
[an error occurred while processing this directive] FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
[an error occurred while processing this directive]
modENCODE Development RNA-Seq
[an error occurred while processing this directive] modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
[an error occurred while processing this directive]
modENCODE Treatments RNA-Seq
[an error occurred while processing this directive]
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_18 mE1_20_mRNA_expression_cluster_15
External Data & Images
Linkouts	BDGP expression data • GH06739
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal, with Scer\GAL4how-24B tnGD8908 lethal (with Df(2R)Exel6068) tn1 tnΔA tnΔB lethal (with tn1) tnΔA tnΔB lethal (with tnΔA) tn1 lethal (with tnΔB) tn1 lethal | recessive tn1 viable tnf02741 viable, with Scer\GAL4pnr-MD237 tnGD8908 Sterility Allele fertile tnf02741 Other Phenotypes Allele developmental rate defective tn1 visible | pupal stage, with Scer\GAL4how-24B tnGD8908 visible | pupal stage (with Df(2R)Exel6068) tn1 tnΔA visible | pupal stage (with tn1) tnΔA tnΔB visible | pupal stage (with tnΔA) tn1 visible | pupal stage (with tnΔB) tn1 Phenotype manifest in Allele embryonic/larval somatic muscle | third instar larval stage, with Scer\GAL4how-24B tnGD8908 embryonic/larval somatic muscle | third instar larval stage (with Df(2R)Exel6068) tn1 tnΔA myofibril | third instar larval stage, with Scer\GAL4how-24B tnGD8908 myofibril | third instar larval stage (with Df(2R)Exel6068) tn1 tnΔA
Classical Alleles ( 7 )
For All Classical Alleles Show
Allele of tn Class Mutagen Stocks Known lesion tnf02741 piggyBac transposase 2 -- tnMB03490 1 -- tnMB10738 1 -- tnMI03287 1 -- tnΔA amorphic allele - molecular evidence minos transposase 0 Yes tnΔB amorphic allele - molecular evidence minos transposase 0 Yes tn1 hypomorphic allele - molecular evidence, hypomorphic allele - genetic evidence spontaneous 0 Yes
Alleles Carried on Transgenic Constructs ( 5 )
For All Alleles Carried on Transgenic Constructs Show
Allele of tn Class Mutagen Stocks Known lesion tnGD8908 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes tnHMS02508 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes tnJF01164 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes tnKK102644 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes tnScer\UAS.cLa in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2R)Exel6068 (Ryder, 2004.4.26, Labeau-Dimenna et al., 2012)
Not disrupted in	Df(2R)BSC349 (Labeau-Dimenna et al., 2012) Df(2R)Exel6067 (Labeau-Dimenna et al., 2012)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{TRiP.HMS02508} NA P{UAS-tn.L} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions Mi{MIC}tnMI03287 NA PBac{WH}tnf02741 NA insertion of enhancer trap binary system Mi{ET1}tnMB03490 No Mi{ET1}tnMB10738 No
Gene Ontology: Function, Process & Cellular Component ( 4 unique terms )
Terms Based on Experimental Evidence ( 3 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
muscle cell homeostasis inferred from mutant phenotype (Labeau-Dimenna et al., 2012) muscle fiber development inferred from mutant phenotype (Labeau-Dimenna et al., 2012)
Cellular Component
CV term Evidence References
Z disc inferred from direct assay (Labeau-Dimenna et al., 2012)
Terms Based on Predictions or Assertions ( 1 term )
Molecular Function
CV term Evidence References
zinc ion binding inferred from electronic annotation with InterPro:IPR001841 (FlyBase Curators et al., 2004-)
Biological Process ( 0 terms)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	gene   gene_with_edited_transcript (Graveley et al., 2011) nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions tn allele Gene References
External Data
Linkouts
Orthologs
OrthoDB Orthologs (38) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG63XVPJ Dipteran inclusive ortholog search EOG6B8JN8 Insect inclusive ortholog search EOG6QRG04 Arthropod inclusive ortholog search EOG6JDFNT Metazoa inclusive ortholog search EOG62VN8M
Orthologs in Drosophila Species (EOG63XVPJ)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\tn     Drosophila sechellia   Dsec\GM21930     Drosophila erecta   Dere\GG21942 Y   Drosophila yakuba   Dyak\GE12016 Y   Drosophila ananassae   Dana\GF11130 Y   Drosophila willistoni   Dwil\GK24958     Drosophila willistoni   Dwil\GK20936 Y   Drosophila virilis   Dvir\GJ19924 Y   Drosophila mojavensis   Dmoj\GI19367 Y   Drosophila grimshawi   Dgri\GH22138 Y
Orthologs in non-Drosophila Dipterans (EOG6B8JN8)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL003104   Anopheles gambiae Malaria mosquito  Agam\AGAP007135   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ003685   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ000093
Orthologs in non-Dipteran Insects (EOG6QRG04)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB48007   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG009245   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH16954   Atta cephalotes Leafcutter ant  Acep\ACEP21394   Atta cephalotes Leafcutter ant  Acep\ACEP21391   Atta cephalotes Leafcutter ant  Acep\ACEP21387   Camponotus floridanus Florida carpenter ant  Cflo\CFLO18032   Camponotus floridanus Florida carpenter ant  Cflo\CFLO23603   Camponotus floridanus Florida carpenter ant  Cflo\CFLO18031   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL13640   Linepithema humile Argentine ant  Lhum\LH11114   Linepithema humile Argentine ant  Lhum\LH11110   Linepithema humile Argentine ant  Lhum\LH11112   Pogonomyrmex barbatus Red harvester ant  Pbar\PB18597   Pogonomyrmex barbatus Red harvester ant  Pbar\PB18596   Solenopsis invicta Red fire ant  Sinv\SINV10351   Solenopsis invicta Red fire ant  Sinv\SINV10354   Acyrthosiphon pisum Pea aphid  Apim\ACYPI008521   Bombyx mori Silkmoth  Bmor\BGIBMGA014126   Pediculus humanus Human body louse  Phum\PHUM256370   Tribolium castaneum Red flour beetle  Tcas\TC012517
Orthologs in non-Insect Arthropods (EOG6JDFNT)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\Zfp68   Ixodes scapularis Deer tick  Isca\ISCW017943
Orthologs in non-Arthropod Metazoa (EOG62VN8M)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\nhl-1
Human Orthologs (0)
Gene OMIM HGNC
AAA Orthologs (10) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD11426 Drosophila erecta Dere\GG21942 Drosophila yakuba Dyak\GE12016 Drosophila ananassae Dana\GF11130 Drosophila pseudoobscura pseudoobscura Dpse\GA13495 Drosophila persimilis Dper\GL11502 Drosophila willistoni Dwil\GK20936 Drosophila virilis Dvir\GJ19924 Drosophila mojavensis Dmoj\GI19367 Drosophila grimshawi Dgri\GH22138
Stocks & Reagents
Stocks Listed in FlyBase ( 10 )
Bloomington	18581 w1118; PBac{WH}tnf02741 24804 w1118; Mi{ET1}tnMB03490 29901 w1118; Mi{ET1}tnMB10738 31588 y1 v1; P{TRiP.JF01164}attP2 37174 y1 w*; Mi{MIC}tnMI03287 42826 y1 sc* v1; P{TRiP.HMS02508}attP40/CyO
Harvard	- PBac{WH}tnf02741
VDRC	v107067 P{KK102644}VIE-260B v19290 w1118; P{GD8908}v19290 v19291 w1118; P{GD8908}v19291
Genomic Clones ( 1 )
	BACR08I18 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 54 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GH06739
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH23288 GH27935 LP06959 RE06764 RE24977 RE38610 RE39654 RE44892 RE49658 RH45634 RH48939 RH52485 RH66658
Other clones	10725 38367 39443 62942 69237 80617 98001 105759 106166 121352 147729 153867 155716 157305 160494 166281 175198.2 175280 214283.44 214537.69 CK01.38C.G7 CK01.48D.C8 CK01.92D.G1 CK01.128D.C3 EK040944 EK072525 EK099810 EK110845 EK139803 EK145901 EK151545 EK213963 EK215501 EK220749 EK251414 EK253133 EK257441 EK258656 EK271105 GH22795
RNAi & Array Information
Linkouts
Antibody Information
	polyclonal (Labeau-Dimenna et al., 2012)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: abba CG15105 (O'Farrell et al., 2008)
Source for database merge of	Source for merge of: tn abba (Labeau-Dimenna et al., 2012)
Additional comments	snoRNA:abba-a is encoded in an intron of abba. (Graveley et al., 2011)
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_137546 NM_166318 NM_001144235 RefSeq (Proteins) • NP_611390 NP_725843 NP_001137707 DDBJ / EMBL / GenBank • AAF57611 AAF57612 AAM51947 ACL83161 AI106668 AW940241 AY121620 CZ485287 CZ485288 Entrez Gene - A searchable database of RefSeq genes. • 37190 UniProtKB/TrEMBL • B7YZK8 Q7JUV6
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Zinc finger, RING-type (IPR001841) NHL repeat, subgroup (IPR013017) Six-bladed beta-propeller, TolB-like (IPR011042) Zinc finger, C3HC4 RING-type (IPR018957) NHL repeat (IPR001258) Zinc finger, RING/FYVE/PHD-type (IPR013083) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • GH06739
Linkouts
Synonyms & Secondary IDs ( 8 )
Reported As
Symbol Synonym	abba (O'Farrell et al., 2008, Graveley et al., 2011) CG15105 (Ni et al., 2010.12.1, Labeau-Dimenna et al., 2012, O'Farrell et al., 2008, Riedl et al., 2007, Grimberg et al., 2011, Cardoso et al., 2006, Keleman et al., 2009.8.5, Zimmermann et al., 2006, Ni et al., 2008, Ying et al., 2011) l(2)tn (Labeau-Dimenna et al., 2012, ) tn (Labeau-Dimenna et al., 2012, )
Name Synonym	another B-box affiliate   Another B-Box Affiliate (O'Farrell et al., 2008) CG15105   l(2)thin (Labeau-Dimenna et al., 2012) thin
Secondary FlyBase IDs
	FBgn0003726 FBgn0034412
References ( 35 )
Generate a list of	All references relating to this gene ( 35 )
List References by type	Research paper  ( 9 ) Supplementary material  ( 6 ) Personal communication to FlyBase  ( 13 ) FlyBase analysis  ( 3 ) Website  ( 1 ) Book  ( 1 ) Curated genome annotation  ( 2 )
Recent research papers ( 3 )
	Labeau-Dimenna et al., 2012, Proc. Natl. Acad. Sci. U.S.A. 109(44): 17983--17988 Thin, a Trim32 ortholog, is essential for myofibril stability and is required for the integrity of the costamere in Drosophila. [FBrf0219862] Grimberg et al., 2011, Mol. Cell. Biol. 31(4): 897--909 Basic Leucine Zipper Protein Cnc-C Is a Substrate and Transcriptional Regulator of the Drosophila 26S Proteasome. [FBrf0212906] Ying et al., 2011, PLoS ONE 6(9): e23863 Comprehensively Surveying Structure and Function of RING Domains from Drosophila melanogaster. [FBrf0215242] Show all research papers ...