A Database of Drosophila Genes & Genomes

FB2013_03, released May 7th, 2013
 

Gene Dmel\Neto

General Information
SymbolDmel\NetoSpeciesD. melanogaster
NameNeuropilin and tolloid-likeAnnotation symbolCG44328
Feature typeprotein_coding_geneFlyBase IDFBgn0265416
Gene Model StatusCurrent Stock availability 14 publicly available
Also Known AsCG32635
Genomic Location
Chromosome (arm)XRecombination map
Cytogenetic map12A2-12A2Sequence locationX:13,339,936..13,421,315 [+]

Genomic Maps

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Automatically generated summary

See sections below for more information
The gene Neuropilin and tolloid-like is referred to in FlyBase by the symbol Dmel\Neto (CG44328, FBgn0265416). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. There is experimental evidence that it is involved in the biological process: neuromuscular synaptic transmission; locomotion; lateral inhibition; neuromuscular junction development; receptor clustering; hatching behavior; postsynaptic density organization; flight. 20 alleles are reported. The phenotypes of these alleles are annotated with: neuromuscular junction; mesothoracic tergum. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: CUB domain; Low-density lipoprotein (LDL) receptor class A repeat. Gene sequence location is X:13339936..13421315.

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Description
What does this section display?
This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms).
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This section does not currently display links that were removed or gene model changes.
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FB2013_03
Controlled Vocabulary Terms
FB2013_02
All updates Click here to see a list of all updates to this record from FB2010_08 and on.
hide Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map
Evidence for location
12A2-12A2  
Limits computationally determined from genome sequence between P{EP}CG1640EP1626 and P{EP}NFATEP1353&P{EP}NFATEP1508  
Experimentally Determined Cytological Location
Cytogenetic map
Notes
References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
hide Gene Model & Products
Please see the GBrowse view of Dmel\Neto for information on other features GBrowse View Help
To submit a correction to a gene model please use the Contact FlyBase form
detailed view FBtr0339703 FBtr0339702 FBtr0112526 FBtr0073782 FBtr0340432 FBpp0111438 FBpp0308759 FBpp0308760 FBpp0073613 FBti0042113 FBti0052913 FBti0071910 FBti0114154 FBti0101679 FBti0078300 FBti0149038 FBti0021216 FBti0114161
Comments on Gene Model
Supported by strand-specific RNA-Seq data.
Gene model reviewed during 5.49
hide Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Associated CDS (aa)
FBtr0339702
 
  3362
  677
FBtr0339703
 
  6903
  822
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
hide Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank protein
FBpp0308759  
75.9  
677  
4.30  
 
 
FBpp0308760  
91.9  
822  
6.96  
 
 
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences
InterPro domains - A database of protein families, domains, and functional sites
hide Sequences Consistent with the Gene Model
DDBJ /
EMBL /
GenBank
DNA sequence
Protein sequence
Name
 
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL
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Mapped Features have been reorganized, please see this article for details.
Additional mapped features and mutations can be found on GBrowse or related reports.
Type
Symbol & Location
Additional Notes
References
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Linkouts
Crossreferences
hide Expression Data
hideTranscript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
hide Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data
Neto protein is expressed in the active zone of type I boutons at the neuromuscular junction.
Marker for
Subcellular Localization (GO Cellular Component)
CV term
References
inferred from direct assay
inferred from direct assay
hide Expression Deduced from Reporters
hide High-Throughput Expression Data
Associated Tools
Reference
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
hide FlyAtlas Anatomy Microarray
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FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
hide modENCODE Anatomy RNA-Seq
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[an error occurred while processing this directive]
modENCODE Temporal Expression Data (Graveley et al., 2011)
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hide Expression Clusters
A cluster of genes with similar mRNA expression dynamics across development.
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Linkouts
hide Alleles & Phenotypes
hide Summary of Allele Phenotypes
Lethality
Allele
Sterility
Allele
Other Phenotypes
Allele
Phenotype manifest in
Allele
hide Classical Alleles ( 12 )
For All Classical Alleles Show

Allele of NetoClassMutagenStocksKnown lesion
Netof023352 --
Netof063811 --
NetoKG03784
1 --
NetoMB04917
1 --
NetoMB05569
1 --
NetoMB06658
1 --
NetoMB07125
1 --
NetoMI05339
1 --
Neto1090 Yes
Neto140 Yes
Neto360 Yes
NetoGG01143
0 --
hide Alleles Carried on Transgenic Constructs ( 8 )
For All Alleles Carried on Transgenic Constructs Show

Allele of NetoClassMutagenStocksKnown lesion
NetoGD78101 Yes
NetoGD91071 Yes
NetoGD91081 Yes
NetoGD91091 Yes
NetoKK1097901 Yes
NetoScer\UAS.cKa0 Yes
NetoScer\UAS.T:Avic\GFP-EGFP0 Yes
NetoScer\UAS.T:SV5\V5,T:Zzzz\His60 Yes
hide Aneuploid Aberrations
Disrupted in
Duplicated in
hide Transgenic Constructs & Insertions
Transgenic Constructs
Type of construct
Name
Expression data
Insertions
Type of insertions
Name
Expression data
insertion of mobile activating element
insertion of enhancer trap binary system
hide Gene Ontology: Function, Process & Cellular Component ( 12 unique terms )

There is no information supporting a molecular function term for this gene.

(Based on a review of available data on: 2012-07-02)

hide Terms Based on Experimental Evidence ( 12 terms )
Molecular Function ( 0 terms)
Biological Process
CV term
References
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from direct assay
Cellular Component
CV term
References
inferred from direct assay
inferred from direct assay
hide Terms Based on Predictions or Assertions ( 0 terms )
hide Sequence Ontology: Class of Gene
hide Interactions & Pathways
hide Summary of Physical Interactions
protein-protein
Interacting group
Assay
References
anti tag coimmunoprecipitation, western blot
hide Summary of Genetic Interactions
Interacts with
Please look at the allele data for full details of the genetic interactions
Neto allele
Gene
References
hide External Data
Linkouts
hide Orthologs
hide OrthoDB Orthologs (56) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
Drosophila inclusive ortholog search
Dipteran inclusive ortholog search
Insect inclusive ortholog search
Arthropod inclusive ortholog search
Metazoa inclusive ortholog search
hideOrthologs in Drosophila Species (EOG6X6CV0, EOG6R24FH)
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila melanogaster
fruit fly 
 
 
Drosophila simulans
 
 
Y
Drosophila simulans
 
Y
Y
Drosophila sechellia
 
Y
Y
Drosophila sechellia
 
Y
Y
Drosophila erecta
 
Y
Y
Drosophila erecta
 
Y
Y
Drosophila yakuba
 
Y
Y
Drosophila yakuba
 
Y
Y
Drosophila ananassae
 
Y
Y
Drosophila ananassae
 
Y
Y
Drosophila pseudoobscura pseudoobscura
 
Y
Y
Drosophila pseudoobscura pseudoobscura
 
Y
Y
Drosophila persimilis
 
Y
Y
Drosophila persimilis
 
Y
Y
Drosophila willistoni
 
Y
Y
Drosophila willistoni
 
Y
Y
Drosophila virilis
 
Y
Y
Drosophila virilis
 
Y
Y
Drosophila mojavensis
 
Y
Y
Drosophila mojavensis
 
Y
Y
Drosophila grimshawi
 
Y
Y
Drosophila grimshawi
 
Y
Y
hideOrthologs in non-Drosophila Dipterans (EOG66WZHP, EOG62FST0)
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Aedes aegypti
Yellow fever mosquito 
Y
Anopheles gambiae
Malaria mosquito 
Y
Culex quinquefasciatus
Southern house mosquito 
Y
Culex quinquefasciatus
Southern house mosquito 
Y
Culex quinquefasciatus
Southern house mosquito 
Y
hideOrthologs in non-Dipteran Insects (EOG6X0KNR)
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Apis mellifera
Western honey bee 
Amel\GB44199
Y
Nasonia vitripennis
Parasitic wasp 
Nvit\Nasvi2EG010455
Y
Acromyrmex echinatior
Panamanian leafcutter ant 
Aech\AECH14443
Y
Atta cephalotes
Leafcutter ant 
Acep\ACEP26321
Y
Camponotus floridanus
Florida carpenter ant 
Cflo\CFLO22995
Y
Harpegnathos saltator
Jerdons jumping ant 
Hsal\HSAL15319
Y
Linepithema humile
Argentine ant 
Lhum\LH13602
Y
Pogonomyrmex barbatus
Red harvester ant 
Pbar\PB25213
Y
Solenopsis invicta
Red fire ant 
Sinv\SINV12971
Y
Acyrthosiphon pisum
Pea aphid 
Y
Tribolium castaneum
Red flour beetle 
Y
hideOrthologs in non-Insect Arthropods (EOG6HHMHR)
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Daphnia pulex
Water flea 
Y
hideOrthologs in non-Arthropod Metazoa (EOG6M0SV2)
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Caenorhabditis elegans
Nematode 
Y
Strongylocentrotus purpuratus
Purple sea urchin 
Y
Danio rerio
Zebrafish 
Y
Danio rerio
Zebrafish 
Y
Danio rerio
Zebrafish 
Y
Danio rerio
Zebrafish 
Y
Xenopus tropicalis
Western clawed frog 
Y
Xenopus tropicalis
Western clawed frog 
Y
Gallus gallus
Domestic chicken 
Y
Gallus gallus
Domestic chicken 
Y
Mus musculus
House mouse 
Y
Mus musculus
House mouse 
Y
Rattus norvegicus
Norway rat 
Y
Rattus norvegicus
Norway rat 
Y
Homo sapiens
Human 
Y
Homo sapiens
Human 
Y
hide Human Orthologs (2)
Gene
OMIM
HGNC
hideAAA Orthologs (22) based on analysis using Dmel annotation version 4.3
Organism
Gene
Drosophila simulans
Drosophila simulans
Drosophila sechellia
Drosophila sechellia
Drosophila erecta
Drosophila erecta
Drosophila yakuba
Drosophila yakuba
Drosophila ananassae
Drosophila ananassae
Drosophila pseudoobscura pseudoobscura
Drosophila pseudoobscura pseudoobscura
Drosophila persimilis
Drosophila persimilis
Drosophila willistoni
Drosophila willistoni
Drosophila virilis
Drosophila virilis
Drosophila mojavensis
Drosophila mojavensis
Drosophila grimshawi
Drosophila grimshawi
hide Stocks & Reagents
hide Stocks Listed in FlyBase ( 14 )
Bloomington
Harvard
VDRC
hide Genomic Clones ( 3 )
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
hide cDNA Clones ( 30 )
Please Note
This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones
Other clones
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Linkouts
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polyclonal
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hide Relationship to Other Genes
Source for database identity of
Source for identity of: Neto CG32635
Source for database merge of
Source for merge of: CG12727 CG15751 CG15752
Source for merge of: Neto CG15753
Additional comments
Annotations CG32635 and CG15753 merged as CG44328 in release 5.49 of the genome annotation. Merge supported by RNA-seq junction data.
Annotations CG12727, CG15751 and CG15752 merged as CG32635 in release 3 of the genome annotation.
hide Other Comments
RNAi generated by PCR using primers directed to this gene causes a cell growth and viability phenotype when assayed in Kc167 and S2R+ cells.
hide External Crossreferences & Linkouts
Sequence Crossreferences
Entrez Gene - A searchable database of RefSeq genes.
Other Crossreferences
InterPro domains - A database of protein families, domains, and functional sites
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
Linkouts
hide Synonyms & Secondary IDs ( 12 )
Reported As
Symbol Synonym
CG12727
 
CG15751
 
CG15752
 
Neto
 
Name Synonym
Neuropilin and tolloid-like
 
neuropilin and tolloid-like
Secondary FlyBase IDs
  • FBgn0030488
  • FBgn0030489
  • FBgn0030490
  • FBgn0030491
  • FBgn0052635
hide References ( 29 )
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hide Recent research papers ( 2 )
Kim et al., 2012, Genes Dev. 26(9): 974--987
Drosophila Neto is essential for clustering glutamate receptors at the neuromuscular junction. [FBrf0218161]
Guest et al., 2011, BMC Syst. Biol. 5(1): 65
A protein network-guided screen for cell cycle regulators in Drosophila. [FBrf0213913]