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Gene Dmel\zip

General Information
Symbol	Dmel\zip	Species	D. melanogaster
Name	zipper	Annotation symbol	CG15792
Feature type	protein_coding_gene	FlyBase ID	FBgn0265434
Gene Model Status	Current	Stock availability	16 publicly available
Also Known As	MyoII, Myo, MHC, nmMHC, Myo II, E(br), Mhc-c, Myo-II
Genomic Location
Chromosome (arm)	2R	Recombination map
Cytogenetic map	60E11-60E12	Sequence location	2R:20,878,093..20,899,488 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene zipper is referred to in FlyBase by the symbol Dmel\zip (CG15792, FBgn0265434). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: myosin light chain binding. There is experimental evidence for 21 unique biological process terms, many of which group under: single-organism developmental process; cellular component organization or biogenesis; localization; embryonic development via the syncytial blastoderm; actin filament-based process; cellular component movement; embryo development ending in birth or egg hatching; muscle cell differentiation; digestive tract development; regionalization. 52 alleles are reported. The phenotypes of these alleles are annotated with: organ system; organ system subdivision; non-connected developing system; adult segment; portion of tissue; cytoplasmic part; hypodermal muscle of larval abdomen; multicellular structure; acellular anatomical structure; external compound sense organ; late extended germ band embryo. It has 9 annotated transcripts and 9 annotated polypeptides. Protein features are: IQ motif, EF-hand binding site; Myosin head, motor domain; Myosin tail; Myosin, N-terminal, SH3-like. Gene sequence location is 2R:20878093..20899488.
User Contributed Data
	Beta version, feedback welcome
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	Mhc-c: Myosin heavy chain-cytoplasmic (D.P. Kiehart) Encodes a 205 kilodalton myosin heavy chain found in Drosophila cell lines and all Drosophila developmental stages. Antibodies raised against this protein crossreact, but weakly with muscle myosin heavy chain. First appears in preblastoderm embryos; diffusely distributed until syncytial blastoderm at which time localization to cortex and pole cells observed; at cleavage furrow, canals at the time of cellularization; transiently present at points of invagination during gastrulation (Young et al., 1987, 1991). zip: zipper The wild-type allele of zipper is expressed in the nervous system during development and was believed to encode an integral membrane protein necessary for normal axon patterning (Zhao et al., 1988); however it has more recently been shown to encode the heavy chain of cytoplasmic myosin (Kierhart). The mutants are embryonic lethals; abnormalities include a small hole in the ventral thorax, distortion of ventral denticle rows, and defects in head involution and dorsal closure (Nusslein-Volhard et al., 1984; Cote et al., 1987). These defects vary in different alleles and in different embryos from the same egg laying (Cote et al., 1987). The nervous system of mutant embryos also differentiates abnormally, showing local defects in the fasciculation pattern of axons (Zhao et al., 1988), as indicated by antibody stains for neurons and their axons. These CNS abnormalities can be detected after germ band shortening and, together with the molecular data, suggested that neurological rather than epidermal defects are the primary ones in zip mutants (Cote et al., 1987).
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03	Controlled Vocabulary Terms regulation of cell cycle
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 60E11-60E12   Limits computationally determined from genome sequence between P{EP}CG2790EP412&P{EP}CG3776EP835 and P{EP}zipEP856&P{PZ}l(2)1048103263
Experimentally Determined Cytological Location
Cytogenetic map Notes References 60F1-60F3   (determined by in situ hybridisation)   (Spradling et al., 1999) 60F1-60F3   (determined by in situ hybridisation)   (Perrimon et al., 1996) 60F1-60F3   (determined by in situ hybridisation)   (BDGP Project Members, 1994-1999) 60E-60F   (determined by in situ hybridisation)   (Kiehart et al., 1989) 60E9-60F1   (determined by in situ hybridisation)   (Cote et al., 1987)
Experimentally Determined Recombination Data
Location	2-107 (Tearle and Nusslein-Volhard, 1987) 2- (Liu and Montell, 1999)
Left of (cM)
Right of (cM)
Notes	Maps to 2R. (Liu and Montell, 1999)
Gene Model & Products
Please see the GBrowse view of Dmel\zip for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) zip-RA FBtr0072399  NM_079136   6492   2056 zip-RB FBtr0072398  NM_166704   6806   2011 zip-RC FBtr0100466  NM_001014553   6308   1971 zip-RD FBtr0100467  NM_001014552   6372   2016 zip-RE FBtr0302572  NM_001202079   6325   1971 zip-RF FBtr0302573  NM_001202080   6332   1979 zip-RG FBtr0302574  NM_001202081   6319   1971 zip-RH FBtr0302575  NM_001202082   6466   1964 zip-RI FBtr0306576  NM_001259587   6396   2024
Additional Transcript Data & Comments
Reported size (kB)	6.455, 6.391, 6.335, 6.271 (sequence analysis) (Mansfield et al., 1996)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein zip-PA   FBpp0072306   236.6   2056   5.30     NP_523860   AAF47311 zip-PB   FBpp0072305   231.5   2011   5.15     NP_726506   AAM70805 zip-PC   FBpp0099894   226.9   1971   5.13     NP_001014553   AAX52688 zip-PD   FBpp0099896   232.1   2016   5.27     NP_001014552   AAX52687 zip-PE   FBpp0291728   226.9   1971   5.13     NP_001189008   ADV37253 zip-PF   FBpp0291729   227.8   1979   5.13     NP_001189009   ADV37254 zip-PG   FBpp0291730   226.9   1971   5.13     NP_001189010   ADV37255 zip-PH   FBpp0291731   226.8   1964   5.20     NP_001189011   ADV37256 zip-PI   FBpp0297531   233.0   2024   5.27     NP_001246516   AFH08269
Additional Polypeptide Data & Comments
Reported size (kDa)	2057, 2017, 2012, 1972 (aa) (Mansfield et al., 1996) 2017, 1972 (aa); 227 (kD predicted) (Ketchum et al., 1990) 500 (aa); 56 (kD predicted) (Zhao et al., 1988)
Comments	A 2017aa zip protein is predicted by translation from the first AUG of the "long" zip transcript. Antibodies directed against a 15aa peptide specific for part of the amino-terminal 45aa extension react with a protein of the expected size providing evidence for its existence in vivo. (Ketchum et al., 1990) zip protein is most similar to metazoan smooth and nonmuscle myosins. (Ketchum et al., 1990)
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Myosin-like IQ motif-containing domain (IPR027401) P-loop containing nucleoside triphosphate hydrolase (IPR027417) IQ motif, EF-hand binding site (IPR000048) Myosin head, motor domain (IPR001609) Myosin tail (IPR002928) Myosin, N-terminal, SH3-like (IPR004009)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA391735   AA392661   AA540167   AA694828   AA695644   AA696049   AA735726   AA802733   AA803481   AA821218   AA941134   AE013599 AAF47311   AE013599 AAM70805   AE013599 AAX52687   AE013599 AAX52688   AC006244   AE013599 ADV37253   AE013599 ADV37254   AE013599 ADV37255   AE013599 ADV37256   AE013599 AFH08269   AI107796   AI257446   AI259742   AI260059   AI296123   AI296633   AI297148   AI297351   AI297749   AI512786   AI514025   AI520372   AI532394   AI532944   AI535023   AI541805   AI541935   AI543605   AI546594   AQ024980   AQ025602   AX154688   BF485859   BF492457   BF492463   BF493465   BF495698   BF495702   BF503504   BF503505   BF505615   BF506448   BG637072   BI171762   BI214978   BI352464   BI355005   BI355902   BI482560   BI635591   BI637625   BI638693   BI640587   BP540834   BP543165   BP545713   BT024962   BT099996   BT100025   BT100137   BT149863   CK131676   CK658018   CK658655   CK662272   CK662348   CO153031   CO153142   CO153899   CO154138   CO154321   CO155966   CO157015   CO181226   CO183170   CO183525   CO186106   CO187590   CO190226   CO270812   CO283957   CO284711   CO286614   CO288471   CO289709   CO297431   CO300556   CO302417   CO315179   CO323145   CO327504   CO327611   CO336240   CO336437   CO336992   CO337051   CO337400   CO344372   CZ474631   CZ485506   CZ490293   EC057937   EC064479   EC089249   EC202406   EC204145   EC206550   EC207749   EC208760   EC212025   EC218321   EC218998   EC223007   EC223659   EC237763   EC240691   EC240855   EC241386   EC255096   EC262992   EC263326   EC263376   EC263714   EC264250   EC265059   EC265077   EC265567   EC265860   EC266306   EC266431   EC267251   EC268007   EL875167   GH941212   GH943526   GH945085   GH945494   GH945753   GH947698   GH948394   GH949474   GH949584   GH950387   GH951510   GH952267   GH955341   GH956740   GH958936   GH962570   GH963144   GH963150   GH965341   GH965940   GH966236   GH966693   GH966858   GH967507   GH967654   GH971530   GH971796   GH972157   GH976056   GH976223   GH977513   GH979218   GH979466   GH980183   GH980262   GH981004   GH983399   GH983971   GH984143   GH984561   GH984693   GH985067   HM449891   M35012 AAA28713   U35816 AAB09048   U35816 AAB09049   U35816 AAB09050   U35816 AAB09051
UniProtKB/Swiss-Prot	Q99323
UniProtKB/TrEMBL	Q59E58 Q59E59
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage   presumptive embryonic/larval central nervous system   (Zhao et al., 1988) embryonic stage 1 -- 3   organism   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 4 -- 6   organism   (Fisher et al., 2012) embryonic stage 7 -- 8   anterior endoderm anlage   (Fisher et al., 2012) head mesoderm   (Fisher et al., 2012) posterior endoderm   (Fisher et al., 2012) trunk mesoderm   (Fisher et al., 2012) embryonic stage 9 -- 10   anterior endoderm   (Fisher et al., 2012) head mesoderm   (Fisher et al., 2012) posterior endoderm   (Fisher et al., 2012) trunk mesoderm   (Fisher et al., 2012) embryonic stage 11 -- 12   head mesoderm   (Fisher et al., 2012) posterior midgut primordium   (Fisher et al., 2012) trunk mesoderm   (Fisher et al., 2012) embryonic stage 13 -- 15   embryonic leading edge cell   (Arquier et al., 2001) embryonic stage 13 -- 16   embryonic head epidermis   (Fisher et al., 2012) embryonic/larval dorsal vessel   (Fisher et al., 2012) embryonic/larval midgut   (Fisher et al., 2012) embryonic/larval muscle system   (Fisher et al., 2012) radioisotope in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 8   mesoderm   (Cote et al., 1987) RNase protection, primer extension, SI map Stage Tissue/Position (including subcellular localization) Reference embryonic stage & adult stage     (Ketchum et al., 1990)
Additional Descriptive Data
Marker for
	embryonic leading edge cell
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization Stage Tissue/Position (including subcellular localization) Reference embryonic stage 13   embryonic leading edge cell   (Arquier et al., 2001) embryonic stage 16   muscle attachment site   (Bloor and Kiehart, 2001) mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 7 of adulthood -- day 49 of adulthood   adult heart   (Cammarato et al., 2011)
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
cell cortex inferred from direct assay (Liu et al., 2008) inferred from mutant phenotype (Franke et al., 2005) cleavage furrow inferred from direct assay (Liu et al., 2008) myosin II complex inferred from direct assay (Liu et al., 2008) inferred from physical interaction with Mlc-c (Franke et al., 2006) inferred from physical interaction with sqh (Franke et al., 2006) Z disc inferred from direct assay (Bloor and Kiehart, 2001)
Expression Deduced from Reporters
Reporter: P{PZ}zip02957 Stage Tissue/Position (including subcellular localization) Reference wandering third instar larval stage   imaginal disc   (Meister and Braun, 1995.10) embryonic/larval brain   (Meister and Braun, 1995.10) embryonic/larval salivary gland   (Meister and Braun, 1995.10) embryonic/larval foregut   (Meister and Braun, 1995.10) embryonic/larval midgut   (Meister and Braun, 1995.10) embryonic/larval hindgut   (Meister and Braun, 1995.10)
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
[an error occurred while processing this directive] FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
[an error occurred while processing this directive]
modENCODE Development RNA-Seq
[an error occurred while processing this directive] modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
[an error occurred while processing this directive]
modENCODE Treatments RNA-Seq
[an error occurred while processing this directive]
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_23 mE1_20_mRNA_expression_cluster_02
External Data & Images
Linkouts	BDGP expression data • PC00310
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal zip17F1 zipCC01626 zipGD1566 lethal, with Scer\GAL4Act5C.PU zipGD1566 lethal, with Scer\GAL4Bx-MS1096 zipGD1566 lethal, with Scer\GAL4en-e16E zipDN.Scer\UAS.T:Avic\GFP lethal, with Scer\GAL4en-e16E, zip1 zipDN.Scer\UAS.T:Avic\GFP lethal, with Scer\GAL4en-e16E, zipDN.Scer\UAS.T:Avic\GFP zip1 lethal, with Scer\GAL4GMR.PF, Scer\GAL4ey.PH zipGD1566 lethal, with Scer\GAL4pnr-MD237 zipGD1566 lethal, with Scer\GAL4tsh-md621 zipGD1566 lethal (with zip1) zip2 lethal (with zip2) zip1 zipmhc-c1.6 lethal (with zipmhc-c1.6) zip2 lethal | embryonic stage zip1 zip2 zipIIX62 zipmhc-c1.3 zipmhc-c1.6 zipmhc-c2.1 zipmhc-c3.9 zipmhc-c3.12 zipmhc-c6.1 zipmhc-c14 lethal | embryonic stage (with zip1) zip2 lethal | embryonic stage (with zip2) zip1 lethal | embryonic stage | paternal effect | heat sensitive ziphs.P lethal | embryonic stage | recessive zip1 zip2 zipmhc-c1.3 zipunspecified lethal | larval stage zip2 zip3 zip4 lethal | larval stage (with Df(2R)gsb) zip3 zip4 lethal | larval stage (with zip1) zip2 zip3 zip4 lethal | larval stage (with zip2) zip1 zip3 zip4 lethal | larval stage (with zip3) zip1 zip2 zip4 lethal | larval stage (with zip4) zip1 zip2 zip3 lethal | pupal stage, with Scer\GAL4pnr-MD237 zipGD1566 lethal | recessive zip2 zip17F1 zip33-1 zip02957 zipEbr zipk15609 zipmhc-c2.1 zipmhc-c6.1 zipSu(flw)1 zipSu(flw)2 zipSu(flw)3 partially lethal - majority live (with zip33-1) zipEbr partially lethal - majority live (with zipEbr) zip33-1 Other Phenotypes Allele axis specification defective | embryonic stage 15 (with Df(2R)gsb) zip3 zip4 axis specification defective | embryonic stage 15 (with zip1) zip2 zip3 zip4 axis specification defective | embryonic stage 15 (with zip2) zip1 zip3 zip4 axis specification defective | embryonic stage 15 (with zip3) zip1 zip2 zip4 axis specification defective | embryonic stage 15 (with zip4) zip1 zip2 zip3 axis specification defective | embryonic stage 15 | recessive zip2 zip3 zip4 axis specification defective | embryonic stage 16 (with Df(2R)gsb) zip3 zip4 axis specification defective | embryonic stage 16 (with zip1) zip2 zip3 zip4 axis specification defective | embryonic stage 16 (with zip2) zip1 zip3 zip4 axis specification defective | embryonic stage 16 (with zip3) zip1 zip2 zip4 axis specification defective | embryonic stage 16 (with zip4) zip1 zip2 zip3 axis specification defective | embryonic stage 16 | recessive zip2 zip3 zip4 axis specification defective | embryonic stage 17 (with Df(2R)gsb) zip3 zip4 axis specification defective | embryonic stage 17 (with zip1) zip2 zip3 zip4 axis specification defective | embryonic stage 17 (with zip2) zip1 zip3 zip4 axis specification defective | embryonic stage 17 (with zip3) zip1 zip2 zip4 axis specification defective | embryonic stage 17 (with zip4) zip1 zip2 zip3 axis specification defective | embryonic stage 17 | recessive zip2 zip3 zip4 cell shape defective zip1 electrophoretic variant zipmhc-c1.3 mitotic cell cycle defective zipdsRNA.cHa neuroanatomy defective | larval stage zipGD1566 planar polarity defective | heat sensitive, with Scer\GAL4pnr-MD237, Scer\GAL80ts.αTub84B zipDN.Scer\UAS.T:Avic\GFP short lived | calorie restriction conditional, with Scer\GAL4Cg.PA zipDN.Scer\UAS.T:Avic\GFP visible, with Scer\GAL4ap-md544 zipDN.Scer\UAS.T:Avic\GFP zipRod.Scer\UAS.T:Avic\GFP visible, with Scer\GAL4en-e16E zipDN.Scer\UAS.T:Avic\GFP zipFL.Scer\UAS.T:Avic\GFP zipHMM.Scer\UAS.T:Avic\GFP zipRod.Scer\UAS.T:Avic\GFP zipRod.Scer\UAS visible, with Scer\GAL4en-e16E, zip1 zipFL.Scer\UAS.T:Avic\GFP zipHMM.Scer\UAS.T:Avic\GFP zipRod.Scer\UAS.T:Avic\GFP zipRod.Scer\UAS visible, with Scer\GAL4en-e16E, zipFL.Scer\UAS.T:Avic\GFP zip1 visible, with Scer\GAL4en-e16E, zipHMM.Scer\UAS.T:Avic\GFP zip1 visible, with Scer\GAL4en-e16E, zipRod.Scer\UAS.T:Avic\GFP zip1 visible, with Scer\GAL4en-e16E, zipRod.Scer\UAS zip1 visible (with zip33-1) zipEbr visible (with zip02957) zipEbr visible (with zipEbr) zip33-1 zip02957 visible | somatic clone zipmhc-c2.1 wild-type zipCA.Ubi-p63E.T:Hsap\MYC zipSA2.Ubi-p63E.T:Hsap\MYC zipSD2.Ubi-p63E.T:Hsap\MYC zipUbi-p63E.T:Hsap\MYC Phenotype manifest in Allele A1-7 ventral acute muscle 1 zip2 A1-7 ventral acute muscle 1 (with Df(2R)ES1) zip1 A1-7 ventral acute muscle 2 zip2 A1-7 ventral acute muscle 2 (with Df(2R)ES1) zip1 A1-7 ventral acute muscle 3 zip2 A1-7 ventral acute muscle 3 (with Df(2R)ES1) zip1 adult brain zip1 amnioserosa (with zip1) zip2 amnioserosa (with zip2) zip1 zipIIX62 amnioserosa (with zipIIX62) zip2 anterior embryonic/larval midgut | embryonic stage 15 zip2 zip4 anterior embryonic/larval midgut | embryonic stage 15 (with Df(2R)gsb) zip3 zip4 anterior embryonic/larval midgut | embryonic stage 15 (with zip1) zip2 zip3 zip4 anterior embryonic/larval midgut | embryonic stage 15 (with zip2) zip1 zip3 zip4 anterior embryonic/larval midgut | embryonic stage 15 (with zip3) zip1 zip2 zip4 anterior embryonic/larval midgut | embryonic stage 15 (with zip4) zip1 zip2 zip3 anterior embryonic/larval midgut | embryonic stage 16 zip2 zip4 anterior embryonic/larval midgut | embryonic stage 16 (with Df(2R)gsb) zip3 zip4 anterior embryonic/larval midgut | embryonic stage 16 (with zip1) zip2 zip3 zip4 anterior embryonic/larval midgut | embryonic stage 16 (with zip2) zip1 zip3 zip4 anterior embryonic/larval midgut | embryonic stage 16 (with zip3) zip1 zip2 zip4 anterior embryonic/larval midgut | embryonic stage 16 (with zip4) zip1 zip2 zip3 anterior embryonic/larval midgut | embryonic stage 17 zip2 zip4 anterior embryonic/larval midgut | embryonic stage 17 (with Df(2R)gsb) zip3 zip4 anterior embryonic/larval midgut | embryonic stage 17 (with zip1) zip2 zip3 zip4 anterior embryonic/larval midgut | embryonic stage 17 (with zip2) zip1 zip3 zip4 anterior embryonic/larval midgut | embryonic stage 17 (with zip3) zip1 zip2 zip4 anterior embryonic/larval midgut | embryonic stage 17 (with zip4) zip1 zip2 zip3 border follicle cell | somatic clone zip17F1 central nervous system zip1 zip2 cuticle zip1 zip2 denticle zip1 denticle field zip1 denticle row zip1 dorsal closure embryo zip2 zipunspecified dorsal closure embryo (with zip1) zip2 dorsal closure embryo (with zip2) zip1 zipIIX62 dorsal closure embryo (with zipIIX62) zip2 elongation stage spermatid & nucleus ziphs.P embryo | anterior zipunspecified embryonic/first instar larval cuticle | dorsal zip02957 embryonic/larval brain | embryonic stage zip1 zip2 embryonic/larval cuticle zip1 embryonic/larval dorsal trunk (with zip1) zip2 embryonic/larval dorsal trunk (with zip2) zip1 embryonic/larval midgut | embryonic stage zipmhc-c1.3 embryonic/larval muscle system zip2 embryonic/larval neuroblast | larval stage zipGD1566 embryonic/larval salivary gland | embryonic stage zip2 zipmhc-c1.3 embryonic dorsal epidermis zip1 zip2 embryonic dorsal epidermis, with Scer\GAL4en-e16E zipFL.Scer\UAS.T:Avic\GFP embryonic dorsal epidermis, with Scer\GAL4en-e16E, zip1 zipDN.Scer\UAS.T:Avic\GFP embryonic dorsal epidermis, with Scer\GAL4en-e16E, zip2/zip1 zipFL.Scer\UAS.T:Avic\GFP embryonic dorsal epidermis, with Scer\GAL4en-e16E, zipDN.Scer\UAS.T:Avic\GFP zip1 embryonic dorsal epidermis (with zip1) zip2 embryonic dorsal epidermis (with zip1), with Scer\GAL4en-e16E, zipFL.Scer\UAS.T:Avic\GFP zip2 embryonic dorsal epidermis (with zip2) zip1 embryonic dorsal epidermis (with zip2), with Scer\GAL4en-e16E, zipFL.Scer\UAS.T:Avic\GFP zip1 embryonic epidermis zipunspecified embryonic esophagus | embryonic stage 17 zip2 zip3 zip4 embryonic head zip1 zip2 zipIIX62 zipmhc-c1.3 embryonic head (with zip1) zipIIX62 embryonic head (with zipIIX62) zip1 embryonic leading edge cell zip1 zipIIX62 embryonic leading edge cell (with zip1) zip2 zipIIX62 embryonic leading edge cell (with zip2) zip1 zipIIX62 embryonic leading edge cell (with zipIIX62) zip1 zip2 embryonic Malpighian tubule zip1 zip2 zipmhc-c1.3 embryonic proventriculus | embryonic stage 15 zip2 zip4 embryonic proventriculus | embryonic stage 15 (with Df(2R)gsb) zip3 zip4 embryonic proventriculus | embryonic stage 15 (with zip1) zip2 zip3 zip4 embryonic proventriculus | embryonic stage 15 (with zip2) zip1 zip3 zip4 embryonic proventriculus | embryonic stage 15 (with zip3) zip1 zip2 zip4 embryonic proventriculus | embryonic stage 15 (with zip4) zip1 zip2 zip3 embryonic proventriculus | embryonic stage 16 zip2 zip4 embryonic proventriculus | embryonic stage 16 (with Df(2R)gsb) zip3 zip4 embryonic proventriculus | embryonic stage 16 (with zip1) zip2 zip3 zip4 embryonic proventriculus | embryonic stage 16 (with zip2) zip1 zip3 zip4 embryonic proventriculus | embryonic stage 16 (with zip3) zip1 zip2 zip4 embryonic proventriculus | embryonic stage 16 (with zip4) zip1 zip2 zip3 embryonic proventriculus | embryonic stage 17 zip2 zip4 embryonic proventriculus | embryonic stage 17 (with Df(2R)gsb) zip3 zip4 embryonic proventriculus | embryonic stage 17 (with zip1) zip2 zip3 zip4 embryonic proventriculus | embryonic stage 17 (with zip2) zip1 zip3 zip4 embryonic proventriculus | embryonic stage 17 (with zip3) zip1 zip2 zip4 embryonic proventriculus | embryonic stage 17 (with zip4) zip1 zip2 zip3 epidermis | dorsal zip1 zip2 zipIIX62 zipmhc-c1.3 zipmhc-c1.6 zipmhc-c14 zipmhc-c2.1 zipmhc-c3.12 zipmhc-c3.9 zipmhc-c6.1 extended germ band embryo zip1 zip2 external sensory organ | ectopic zip1 eye (with zip02957) zipEbr eye (with zipEbr) zip02957 eye disc | somatic clone, with Scer\GAL4Act.PU zipGD1566 filamentous actin & denticle field primordium zip1 filamentous actin | dorsal closure stage (with zip2) zipIIX62 filamentous actin | dorsal closure stage (with zipIIX62) zip2 filopodium zip1 zipIIX62 filopodium (with zip1) zipIIX62 filopodium (with zipIIX62) zip1 ganglion mother cell | larval stage zipGD1566 head zip1 hub cell zip1 I band zip2 labial disc zip1 leg (with zip33-1) zipEbr leg (with zipEbr) zip33-1 macrochaeta, with Scer\GAL4ap-md544 zipDN.Scer\UAS.T:Avic\GFP zipRod.Scer\UAS.T:Avic\GFP male genitalia, with Scer\GAL4Abd-B-LDN zipGD1566 Malpighian tubule zip2 zipmhc-c1.3 mesothoracic tergum | heat sensitive, with Scer\GAL4pnr-MD237, Scer\GAL80ts.αTub84B zipDN.Scer\UAS.T:Avic\GFP metameric furrow | ventral zip1 microchaeta, with Scer\GAL4ap-md544 zipDN.Scer\UAS.T:Avic\GFP zipRod.Scer\UAS.T:Avic\GFP midgut constriction zipmhc-c1.3 mitochondrion zip1 peripheral nervous system zip1 zip2 pigment cell (with zip02957) zipEbr pigment cell (with zipEbr) zip02957 presumptive embryonic/larval nervous system zip1 zip2 presumptive embryonic/larval tracheal system zip1 retina (with zip02957) zipEbr retina (with zipEbr) zip02957 rhabdomere (with zip02957) zipEbr rhabdomere (with zipEbr) zip02957 S2 cell-line & cell zipdsRNA.cHa S2 cell-line & spindle zipdsRNA.cHa S2 cell-line & spindle microtubule zipdsRNA.cHa sarcomere zip2 tracheal primordium zip1 trichome, with Scer\GAL4ap-md544 zipDN.Scer\UAS.T:Avic\GFP zipRod.Scer\UAS.T:Avic\GFP trichome | supernumerary, with Scer\GAL4ap-md544 zipDN.Scer\UAS.T:Avic\GFP zipRod.Scer\UAS.T:Avic\GFP wing, with Scer\GAL4en-e16E, zip1 zipRod.Scer\UAS.T:Avic\GFP wing, with Scer\GAL4en-e16E, zipRod.Scer\UAS.T:Avic\GFP zip1 wing (with zip02957) zipEbr wing (with zipEbr) zip02957 wing | posterior compartment, with Scer\GAL4en-e16E, zip1 zipRod.Scer\UAS wing | posterior compartment, with Scer\GAL4en-e16E, zipRod.Scer\UAS zip1 wing | somatic clone zipmhc-c2.1 wing blade, with Scer\GAL4ap-md544 zipDN.Scer\UAS.T:Avic\GFP wing blade, with Scer\GAL4en-e16E zipHMM.Scer\UAS.T:Avic\GFP wing blade | posterior compartment, with Scer\GAL4en-e16E zipDN.Scer\UAS.T:Avic\GFP zipRod.Scer\UAS zipRod.Scer\UAS.T:Avic\GFP wing hair, with Scer\GAL4en-e16E zipDN.Scer\UAS.T:Avic\GFP zipRod.Scer\UAS wing hair | supernumerary, with Scer\GAL4en-e16E zipDN.Scer\UAS.T:Avic\GFP zipRod.Scer\UAS zipRod.Scer\UAS.T:Avic\GFP wing vein, with Scer\GAL4en-e16E, zip1 zipHMM.Scer\UAS.T:Avic\GFP wing vein, with Scer\GAL4en-e16E, zipHMM.Scer\UAS.T:Avic\GFP zip1 wing vein | ectopic, with Scer\GAL4en-e16E zipFL.Scer\UAS.T:Avic\GFP zipHMM.Scer\UAS.T:Avic\GFP wing vein | ectopic, with Scer\GAL4en-e16E, zip1 zipFL.Scer\UAS.T:Avic\GFP wing vein | ectopic, with Scer\GAL4en-e16E, zipFL.Scer\UAS.T:Avic\GFP zip1 wing vein | somatic clone zipmhc-c2.1
Classical Alleles ( 30 )
For All Classical Alleles Show
Allele of zip Class Mutagen Stocks Known lesion zip1 amorphic allele - genetic evidence ethyl methanesulfonate 2 -- zipIIX62 amorphic allele - genetic evidence 2 Yes zip2 amorphic allele - genetic evidence ethyl methanesulfonate 1 Yes zip02957 P-element activity 1 -- zipd05611 P-element activity 1 -- zipf02948 piggyBac transposase 1 -- zipf07547 piggyBac transposase 1 -- zipk15609 P-element activity 1 -- zipMI02518 1 -- zipMI03943 1 -- zip17F1 ethyl methanesulfonate chemical 0 -- zip33-1 ethyl methanesulfonate 0 -- zip3 ethyl methanesulfonate 0 Yes zip4 ethyl methanesulfonate 0 Yes zipCC01626 P-element activity 0 Yes zipCPTI002907 piggyBac transposase 0 Yes zipCPTI100036 piggyBac transposase 0 Yes zipEbr 0 Yes zipEP856 P-element activity 0 -- zipmhc-c1.3 ethyl methanesulfonate 0 Yes zipmhc-c1.6 ethyl methanesulfonate 0 -- zipmhc-c14 ethyl methanesulfonate 0 -- zipmhc-c2.1 ethyl methanesulfonate 0 -- zipmhc-c3.12 ethyl methanesulfonate 0 -- zipmhc-c3.9 ethyl methanesulfonate 0 -- zipmhc-c6.1 ethyl methanesulfonate 0 -- zipSu(flw)1 ethyl methanesulfonate 0 -- zipSu(flw)2 ethyl methanesulfonate 0 -- zipSu(flw)3 ethyl methanesulfonate 0 -- zipunspecified 0 --
Alleles Carried on Transgenic Constructs ( 22 )
For All Alleles Carried on Transgenic Constructs Show
Allele of zip Class Mutagen Stocks Known lesion zipGD1566 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes zipGL00623 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes zipHMS01618 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes zipHMS01703 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes zipCA.Ubi-p63E.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - site directed mutagenesis in vitro construct - amino acid replacement 0 Yes zipD1430N.Scer\UAS.T:Avic\GFP in vitro construct - amino acid replacement 0 Yes zipD1847K.Scer\UAS.T:Avic\GFP in vitro construct - amino acid replacement 0 Yes zipDN.Scer\UAS.T:Avic\GFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes zipdsRNA.cHa in vitro construct - RNAi 0 -- zipFL.Scer\UAS.T:Avic\GFP in vitro construct - coding region fusion in vitro construct - regulatory fusion 0 Yes zipHMM.Scer\UAS.T:Avic\GFP in vitro construct - regulatory fusion in vitro construct - deletion in vitro construct - coding region fusion 0 Yes ziphs.P in vitro construct - regulatory fusion 0 Yes zipNIG.15792R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes zipR1171C.Scer\UAS.T:Avic\GFP in vitro construct - amino acid replacement 0 Yes zipR1933X.Scer\UAS.T:Avic\GFP in vitro construct - amino acid replacement 0 Yes zipRod.Scer\UAS.T:Avic\GFP in vitro construct - regulatory fusion in vitro construct - deletion in vitro construct - coding region fusion 0 Yes zipRod.Scer\UAS in vitro construct - regulatory fusion in vitro construct - deletion 0 Yes zipSA2.Ubi-p63E.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - site directed mutagenesis in vitro construct - amino acid replacement 0 Yes zipScer\UAS.T:Avic\GFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes zipSD2.Ubi-p63E.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - site directed mutagenesis in vitro construct - amino acid replacement 0 Yes zipUbi-p63E.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes zipΔHD.Scer\UAS.T:Avic\GFP-YFP in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - deletion 0 Yes
Aneuploid Aberrations
Not disrupted in	Df(2R)gsb (Gotwals and Fristrom, 1991, Duman-Scheel et al., 1997) Df(2R)Kr10 (Spradling et al., 1999, Preiss et al., 1985, Tearle and Nusslein-Volhard, 1987, Cote et al., 1987, Gotwals and Fristrom, 1991, BDGP Project Members, 1994-1999, Duman-Scheel et al., 1997) Df(2R)M60E (Spradling et al., 1999, BDGP Project Members, 1994-1999) Df(2R)Px2 (Gotwals and Fristrom, 1991) In(2LR)Px4 (Gotwals and Fristrom, 1991)
Disrupted in	Df(2R)BSC608 (Christensen et al., 2008.9.3) Df(2R)ES1 (Bayer et al., 2003, Cote et al., 1987, Gotwals and Fristrom, 1991, Young et al., 1993) Df(2R)gsb (Tearle and Nusslein-Volhard, 1987, Cote et al., 1987, Young et al., 1993)
Partially disrupted in	Df(2R)gsb (Okumura et al., 2010)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD1566} NA P{NIG.15792R} NA P{TRiP.GL00623} NA P{TRiP.HMS01618} NA P{TRiP.HMS01703} NA P{UAS-zip.GFP.D1430N} NA P{UAS-zip.GFP.D1847K} NA P{UAS-zip.GFP.DN} NA P{UAS-zip.GFP.FL} NA P{UAS-zip.GFP.HMM} NA P{UAS-zip.GFP.R1171C} NA P{UAS-zip.GFP.R1933X} NA P{UAS-zip.GFP.Rod} NA P{UAS-zip.GFP} NA P{UAS-zip.Rod} NA P{UAS-zip-DN.GFP-YFP} NA reporter construct P{MHC-lacZ} No heat-shock construct P{hs-mhc-c1} NA characterization construct P{Ubi-p63E-zip.CA} NA P{Ubi-p63E-zip.myc} NA P{Ubi-p63E-zip.SA2} NA P{Ubi-p63E-zip.SD2} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}uzipEP1153 NA P{EP}zipEP856 NA P{XP}zipd05611 NA insertion of enhancer trap P{lacW}l(2)SH0300SH0300 No P{lacW}zipk15609 No P{PZ}zip02957 No miscellaneous insertions Mi{MIC}zipMI02518 NA Mi{MIC}zipMI03943 NA P{PTT-GC}zipCC01626 NA PBac{544.SVS-1}zipCPTI100036 NA PBac{754.P.FSVS-0}zipCPTI002907 NA PBac{WH}zipf02948 NA PBac{WH}zipf07547 NA
Gene Ontology: Function, Process & Cellular Component ( 40 unique terms )
Terms Based on Experimental Evidence ( 28 terms )
Molecular Function
CV term Evidence References
myosin light chain binding inferred from physical interaction with Mlc-c (Franke et al., 2006) inferred from physical interaction with sqh (Franke et al., 2006)
Biological Process
CV term Evidence References
anterior midgut development inferred from mutant phenotype (Okumura et al., 2010) border follicle cell migration inferred from mutant phenotype (Liu and Montell, 1999, Wang et al., 2006) cuticle pattern formation inferred from mutant phenotype (Walters et al., 2006) cytokinesis inferred from mutant phenotype (Rogers et al., 2003, Echard et al., 2004, Eggert et al., 2004, Dean et al., 2005) dorsal closure inferred from mutant phenotype (Riesgo-Escovar et al., 1996, Franke et al., 2005) dorsal closure, amnioserosa morphology change inferred from mutant phenotype (Franke et al., 2005) dorsal closure, leading edge cell differentiation inferred from mutant phenotype (Jacinto et al., 2002) dorsal closure, spreading of leading edge cells inferred from mutant phenotype (Jacinto et al., 2002) establishment of protein localization inferred from mutant phenotype (Dean et al., 2005) head involution inferred from mutant phenotype (Blake et al., 1998) imaginal disc-derived wing hair organization inferred from genetic interaction with dsh (Winter et al., 2001) inferred from genetic interaction with fz (Winter et al., 2001) left/right axis specification inferred from mutant phenotype (Okumura et al., 2010) Malpighian tubule morphogenesis inferred from mutant phenotype (Blake et al., 1998) NOT muscle attachment inferred from genetic interaction with l(2)gl (Bloor and Kiehart, 2001) muscle contraction inferred from mutant phenotype (Bloor and Kiehart, 2001) myofibril assembly inferred from mutant phenotype (Bloor and Kiehart, 2001) myosin II filament assembly inferred from direct assay (Liu et al., 2008) neurogenesis inferred from mutant phenotype (Neumüller et al., 2011) protein oligomerization inferred from direct assay (Liu et al., 2008) regulation of cell cycle inferred from direct assay (Guest et al., 2011) regulation of tube length, open tracheal system inferred from mutant phenotype (Chung et al., 2009) salivary gland morphogenesis inferred from mutant phenotype (Blake et al., 1998) sarcomere organization inferred from mutant phenotype (Bloor and Kiehart, 2001)
Cellular Component
CV term Evidence References
cell cortex inferred from direct assay (Liu et al., 2008) inferred from mutant phenotype (Franke et al., 2005) cleavage furrow inferred from direct assay (Liu et al., 2008) myosin II complex inferred from direct assay (Liu et al., 2008) inferred from physical interaction with Mlc-c (Franke et al., 2006) inferred from physical interaction with sqh (Franke et al., 2006) Z disc inferred from direct assay (Bloor and Kiehart, 2001)
Terms Based on Predictions or Assertions ( 14 terms )
Molecular Function
CV term Evidence References
ATPase activity, coupled inferred from sequence or structural similarity (Goldstein and Gunawardena, 2000) ATP binding inferred from electronic annotation with InterPro:IPR001609, InterPro:IPR004009 (FlyBase Curators et al., 2004-) motor activity inferred from sequence or structural similarity with Saccharomyces MYO1 (Goldstein and Gunawardena, 2000)
Biological Process
CV term Evidence References
anatomical structure morphogenesis non-traceable author statement (Swiss-Prot Project Members, 1994.6.1) cytokinesis non-traceable author statement (Swiss-Prot Project Members, 1994.6.1) dorsal closure traceable author statement (Noselli and Agnes, 1999, Harden, 2002) ecdysone-mediated induction of salivary gland cell autophagic cell death non-traceable author statement (Farkas et al., 2002) establishment of neuroblast polarity traceable author statement (Harden, 2002) establishment of planar polarity non-traceable author statement (Mlodzik, 2002) ovarian follicle cell migration traceable author statement (Dobens and Raftery, 2000)
Cellular Component
CV term Evidence References
apical cortex traceable author statement (Bardin et al., 2004) cytoskeleton non-traceable author statement (Noselli and Agnes, 1999) myosin complex inferred from sequence or structural similarity (Goldstein and Gunawardena, 2000) unconventional myosin complex inferred from sequence or structural similarity (Ketchum et al., 1990) non-traceable author statement (Noselli and Agnes, 1999, Swiss-Prot Project Members, 1994.6.1)
Sequence Ontology: Class of Gene
	gene   gene_with_edited_transcript (Graveley et al., 2011) nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
zip - 7B2 experimental knowledge based (Guruharsha et al., 2011) zip - CG10194 experimental knowledge based (Guruharsha et al., 2011) zip - CG10641 experimental knowledge based (Guruharsha et al., 2011) zip - CG11158 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) zip - CG11459 experimental knowledge based (Guruharsha et al., 2011) zip - CG1809 experimental knowledge based (Guruharsha et al., 2011) zip - CG1885 experimental knowledge based (Guruharsha et al., 2011) zip - CG31546 experimental knowledge based (Guruharsha et al., 2011) zip - CG32445 experimental knowledge based (Guruharsha et al., 2011) zip - CG33107 experimental knowledge based (Guruharsha et al., 2011) zip - CG4662 experimental knowledge based (Guruharsha et al., 2011) zip - CG5590 experimental knowledge based (Guruharsha et al., 2011) zip - CG6347 experimental knowledge based (Guruharsha et al., 2011) zip - CG7366 experimental knowledge based (Guruharsha et al., 2011) zip - CG8149 experimental knowledge based (Guruharsha et al., 2011) zip - CG9377 experimental knowledge based (Guruharsha et al., 2011) zip - CG9689 experimental knowledge based (Guruharsha et al., 2011) zip - Dat experimental knowledge based (Guruharsha et al., 2011) zip - Df31 experimental knowledge based (Guruharsha et al., 2011) zip - Eogt experimental knowledge based (Guruharsha et al., 2011) zip - Fibp experimental knowledge based (Guruharsha et al., 2011) zip - Mlc-c experimental knowledge based (Guruharsha et al., 2011) zip - Pglym87 experimental knowledge based (Guruharsha et al., 2011) zip - Rae1 experimental knowledge based (Guruharsha et al., 2011) zip - Tm1 experimental knowledge based (Guruharsha et al., 2011) zip - awd experimental knowledge based (Guruharsha et al., 2011) zip - capa experimental knowledge based (Guruharsha et al., 2011) zip - eap experimental knowledge based (Guruharsha et al., 2011) zip - regucalcin experimental knowledge based (Guruharsha et al., 2011) zip - retinin experimental knowledge based (Guruharsha et al., 2011) zip - scpr-C experimental knowledge based (Guruharsha et al., 2011)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions zip allele Gene References zip1 CycB (Ji et al., 2002) dsh (Winter et al., 2001) E(br)121 (Ward et al., 2003) flw (Vereshchagina et al., 2004) fz (Winter et al., 2001) Mbs (Lee and Treisman, 2004) S (Gaengel and Mlodzik, 2003) zip2 Moe (Speck et al., 2003) raw (Blake et al., 1999) rib (Blake et al., 1999) zip33-1 Rho1 (Ward et al., 2003, Bayer et al., 2003) Sb (Bayer et al., 2003) zip02957 flw (Vereshchagina et al., 2004) Mbs (Mizuno et al., 2002) S (Gaengel and Mlodzik, 2003) zipEbr br (Chen et al., 2004) E(br)65 (Ward et al., 2003) E(br)121 (Ward et al., 2003) E(br)160 (Ward et al., 2003) E(br)444 (Ward et al., 2003) E(zip)12-5 (Bayer et al., 2003) E(zip)18-5 (Bayer et al., 2003) E(zip)31-6 (Bayer et al., 2003) Mbs (Mizuno et al., 2002) Moe (Speck et al., 2003) Rho1 (Halsell and Kiehart, 1998, Halsell et al., 2000, Mizuno et al., 2002, Ward et al., 2003, Bayer et al., 2003) RhoGEF2 (Halsell et al., 2000, Mizuno et al., 2002, Bayer et al., 2003) rok (Mizuno et al., 2002, Bayer et al., 2003) Sb (Ward et al., 2003, Bayer et al., 2003, Chen et al., 2004) Tm1 (Halsell and Kiehart, 1998) vkg (Halsell and Kiehart, 1998) zipIIX62 flw (Vereshchagina et al., 2004) zipmhc-c1.3 raw (Blake et al., 1999) rib (Blake et al., 1999) zipSu(flw)1 flw (Vereshchagina et al., 2004) unspecified br (Gotwals and Fristrom, 1991) flw (Vereshchagina et al., 2004) l(2)60Dc (von Kalm et al., 1995) l(2)gl (Ohshiro et al., 2000) Sb (Hammonds and Fristrom, 2006) tow (Chung et al., 2007)
External Data
Linkouts
Orthologs
OrthoDB Orthologs (59) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG61G3PF Dipteran inclusive ortholog search EOG6TB4K7 Insect inclusive ortholog search EOG6VDNT9 Arthropod inclusive ortholog search EOG6NP5JB Metazoa inclusive ortholog search EOG6NKQN6
Orthologs in Drosophila Species (EOG61G3PF)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\zip     Drosophila simulans   Dsim\GD24899 Y Y Drosophila sechellia   Dsec\GM25829   Y Drosophila sechellia   Dsec\GM11766   Y Drosophila erecta   Dere\GG19865 Y Y Drosophila yakuba   Dyak\GE11388 Y Y Drosophila ananassae   Dana\GF11513 Y Y Drosophila pseudoobscura pseudoobscura   Dpse\GA13959 Y Y Drosophila persimilis   Dper\GL10886   Y Drosophila willistoni   Dwil\GK20720   Y Drosophila virilis   Dvir\GJ22258 Y Y Drosophila mojavensis   Dmoj\GI19126 Y Y Drosophila grimshawi   Dgri\GH22039 Y Y
Orthologs in non-Drosophila Dipterans (EOG6TB4K7)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL001411 Y Anopheles gambiae Malaria mosquito  Agam\AGAP007523 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ015899 Y
Orthologs in non-Dipteran Insects (EOG6VDNT9)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB51734 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG008888 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH18488 Y Atta cephalotes Leafcutter ant  Acep\ACEP10349 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO12423 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL13770 Y Linepithema humile Argentine ant  Lhum\LH22457 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB24026 Y Solenopsis invicta Red fire ant  Sinv\SINV13859 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI004129 Y Pediculus humanus Human body louse  Phum\PHUM344210 Y Tribolium castaneum Red flour beetle  Tcas\TC005513 Y
Orthologs in non-Insect Arthropods (EOG6NP5JB)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\JGI_V11_306188 Y
Orthologs in non-Arthropod Metazoa (EOG6NKQN6)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\nmy-1 Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_006850gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_021621gn Y Danio rerio Zebrafish  Drer\myh9a Y Danio rerio Zebrafish  Drer\myh11b Y Danio rerio Zebrafish  Drer\myh11 Y Danio rerio Zebrafish  Drer\si:ch211-150d5.2 Y Danio rerio Zebrafish  Drer\si:ch211-120k19.2 Y Danio rerio Zebrafish  Drer\myh10 Y Xenopus tropicalis Western clawed frog  Xtro\myh11 Y Xenopus tropicalis Western clawed frog  Xtro\myh14 Y Xenopus tropicalis Western clawed frog  Xtro\myh10 Y Xenopus tropicalis Western clawed frog  Xtro\myh9 Y Gallus gallus Domestic chicken  Ggal\ENSGALG00000013407 Y Gallus gallus Domestic chicken  Ggal\MYH10 Y Gallus gallus Domestic chicken  Ggal\ENSGALG00000017465 Y Gallus gallus Domestic chicken  Ggal\MYH9 Y Gallus gallus Domestic chicken  Ggal\MYH11 Y Mus musculus House mouse  Mmus\Myh10 Y Mus musculus House mouse  Mmus\Myh11 Y Mus musculus House mouse  Mmus\Myh9 Y Mus musculus House mouse  Mmus\Myh14 Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000000029 Y Rattus norvegicus Norway rat  Rnor\Myh10 Y Rattus norvegicus Norway rat  Rnor\Myh14 Y Rattus norvegicus Norway rat  Rnor\Myh9 Y Homo sapiens Human  Hsap\MYH9 Y Homo sapiens Human  Hsap\MYH14 Y Homo sapiens Human  Hsap\MYH10 Y Homo sapiens Human  Hsap\MYH11 Y
Human Orthologs (4)
Gene OMIM HGNC Hsap\MYH9     Hsap\MYH14     Hsap\MYH10     Hsap\MYH11
AAA Orthologs (8) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD24899 Drosophila erecta Dere\GG19865 Drosophila yakuba Dyak\GE11388 Drosophila ananassae Dana\GF11513 Drosophila pseudoobscura pseudoobscura Dpse\GA13959 Drosophila virilis Dvir\GJ22258 Drosophila mojavensis Dmoj\GI19126 Drosophila grimshawi Dgri\GH22039
Stocks & Reagents
Stocks Listed in FlyBase ( 16 )
Bloomington	35995 y1 w*; Mi{MIC}zipMI02518 40196 y1 w*; Mi{MIC}zipMI03943 11215 cn1 P{PZ}zip02957/CyO; ry506 4199 cn1 bw1 sp1 zip1/CyO 8739 P{FRT(whs)}G13 zip2/CyO, P{lacZ-un3}276 36727 y1 sc* v1; P{TRiP.HMS01618}attP2 37480 y1 sc* v1; P{TRiP.GL00623}attP40
Harvard	- P{XP}zipd05611 - PBac{WH}zipf02948 - PBac{WH}zipf07547
Kyoto	107626 cn1 bw1 sp1 zip1/CyO
VDRC	v7819 w1118; P{GD1566}v7819
	More stocks available...
Genomic Clones ( 1 )
	BACR08I14 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 167 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	IP15304 LP03737
Other clones	IP15404 LD21871 MIP14631
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT03833 AT07875 AT08918 AT13817 AT13832 AT19922 AT26315 AT29377 GH05649 GH27070 GM01629 GM03170 GM04963 GM06230 GM09649 GM13275 GM19388 GM29182 HL02781 HL04531 LD11432 LD11673 LD19558 LD25106 LD40511 LD44816 LP03229 LP05818 LP09941 LP10596 LP11384 LP11635 LP12121 LP12624 LP14503 LP15774 LP22356 LP22476 RE13605 RE21152 RE65264 SD01387 SD03895 SD04602 SD06983 SD07905 SD08034 SD10420 SD16981 SD19678 SD21048 SD23512
Other clones	55671 64246 64459 83496 103771 124530 158310 163535 214309.79 521986 522099 522928 523181 523434 527007 533564 557139 557857 562051 562109 569068 571345 AT01765 CK01.15D.H2 CK01.29B.F9 CK01.35C.D7 CK01.56C.E7 CK01.60A.E8 CK01.86D.H10 CK01.93C.G8 CK01.130A.F6 EC13829 EC25035 EC25909 EK015861 EK030610 EK047437 EK063352 EK068561 EK071842 EK100355 EK164910 EK166614 EK178603 EK184115 EK189825 EK216951 EK239601 EN01131 EN01350 EN03041 EN03554 EN03920 EN07123 EN09747 EN12127 EN12531 EN13623 EN13729 EN14458 EP07408 EP07662 EP19146 FGA008C07 FGC019A04 FGC032G11 IP15204 RP004018466 RP004073045 RP004099195 RP004146338 RP004157068 RP004175564 RP004183916 RP004185074 RP004196422 RP004196809 RP004201649 RP004203455 RP004205638 RP004210351 RP004227122 RP004230357 RP004233481 RP004237005 RP004243143 RP004244914 RP004245318 RP004245528 RP004249965 RP004250523 RP004252516 RP004270018 RP004289116 RP004325029 RP004328693 RP004401796 RP004407368 RP004409981 RP004465536 RP004466480 RP004475168 RP004476917 RP004481927 RP004485975 RP004493165 RP004516984 RP004517506 RP004524033 SD14924
RNAi & Array Information
Linkouts
Antibody Information
	polyclonal (Ketchum et al., 1990, Franke et al., 2010, Cabernard et al., 2010)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: zip anon-WO0140519.37 (FlyBase, 1996-) Source for merge of: zip l(2)17F1 (Wang et al., 2006)
Additional comments	Source for merge of zip anon-WO0140519.37 was sequence comparison (date:051113). (FlyBase, 1996-)
Other Comments
	Overexpression of zip in D.melanogaster males results in paternal-effect lethality that mimics the fertilisation defects associated with cytoplasmic incompatibility (CI) caused by Wolbachia infection. (Clark et al., 2006) dsRNA directed against this gene causes defects in cytokinesis when tested in an RNAi screen in S2 cells. (Echard et al., 2004) RNAi screen using dsRNA made from templates generated with primers directed against this gene causes a binucleation phenotype when assayed in Kc167 cells. (Eggert et al., 2004) dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003) dsRNA made from templates generated with primers directed against this gene is tested in an RNAi screen for effects on actin-based lamella formation. (Rogers et al., 2003) zip is necessary for normal morphology and behaviour of the leading edge cells during embryonic dorsal closure. (Jacinto et al., 2002) zip is required for myofibril formation. zip may function at the muscle termini and the Z line as an actin crosslinker and may act to maintain the structural integrity of the sarcomere. (Bloor and Kiehart, 2001) The zip protein inhibits actomyosin dependent basal protein targeting in neuroblasts. (Peng et al., 2000) 158 deficiency chromosomes have been screened for second site non-complementation with zip alleles, identifying at least 39 SSNC loci, including Tm1, vkg and Rho1. (Halsell and Kiehart, 1998) Mutation rate at microsatellite loci in 119 lines maintained for approximately 250 generations is estimated to be 6.3x10-6, at least one order of magnitude lower than the mutation rate in mammals. (Schlotterer et al., 1998) One of a class of genes with TATA-less promoters that have the conserved DPE sequence. (Burke and Kadonaga, 1996) zip is required for cell sheet movements in embryos. The zip gene product is responsible for a surprisingly diverse array of cell shape changes throughout development. (Edwards and Kiehart, 1996) A serine kinase is tightly associated with l(2)gl. Activation of the serine kinase results in the disassociation of zip from the l(2)gl complex without affecting the homo-oligomerisation of l(2)gl. (Kalmes et al., 1996) Organisation of the transcription unit and alternative splicing of zip are analysed. (Mansfield et al., 1996) The autosomal "FLP-DFS" technique (using the P{ovoD1-18} P{FRT(whs)} P{hsFLP} chromosomes) has been used to study the zygotic lethal mutation. (Perrimon et al., 1996) The p127 protein of the l(2)gl gene is a component of a cytoskeletal network when complexed with a nonmuscle myosin II heavy chain protein, zip. (Mechler, 1995.4.14) Severe alleles disrupt cell shape changes required for embryogenesis. (Edwards and Kiehart, 1994) The zip gene product, nonmuscle myosin, is required for generating and/or maintaining the cell shapes that change during the course of morphogenesis and provides a link between myosin and morphogenesis. (Young et al., 1993) Analysis of myosin heavy chain antibody staining in Drosophila tissue culture cells and premyogenic embryos suggests that zip rather than Mhc is associated with the nuclear envelope. (Berrios et al., 1991) The interaction of zip and br depends on loss of br function and is temperature-dependent. Flies reared at 18oC show a higher penetrance of the mlf phenotype (malformed syndrome), wing malformations and leg defects, than those reared at 25oC. (Gotwals and Fristrom, 1991) zip mutant embryos display defects in dorsal closure, head involution, segmentation and neural pathfinding. (Kiehart et al., 1991) The distribution of zip protein during embryogenesis has been analysed. (Young et al., 1991) Fas3, mys, disco, zip, l(2)gl, N and Egfr mutants show an additive phenotype in combination with Fas1TE89Da. (Elkins et al., 1990) An alternatively spliced exon at the 5' end of zip generates two distinct transcripts. The coding region reveals extensive homology with other conventional myosins. (Ketchum et al., 1990) The zip region is defined by the proximal breakpoint of Df(2R)Kr10 (map position 0 to +3.5) and by the proximal breakpoint of Df(2R)gsb (map position -55 to -49). (Cote et al., 1987) Included in genetic and molecular analysis of the zipper-gooseberry region. (Cote et al., 1987) Five structural and three functional criteria demonstrate a protein purified from S2, S3 and Kc culture cells is a cytoplasmic myosin. (Kiehart and Feghali, 1986) The gene sequenced by Zhao et al. (Zhao et al., 1988, EMBO J. 7) as zip is not zip but the adjacent gene, uzip.   The mutants are embryonic lethals; abnormalities include a small hole in the ventral thorax, distortion of ventral denticle rows and defects in head involution and dorsal closure (FBrf0041708; FBrf0046110). These defects vary in different alleles and in different embryos from the same egg laying (FBrf0046110).   Encodes a 205 kilodalton myosin heavy chain found in Drosophila cell lines and all Drosophila developmental stages. Antibodies raised against this protein crossreact, but weakly with muscle myosin heavy chain. First appears in preblastoderm embryos; diffusely distributed until syncytial blastoderm at which time localization to cortex and pole cells observed; at cleavage furrow, canals at the time of cellularization; transiently present at points of invagination during gastrulation (FBrf0046628; FBrf0053751). produces a truncated myosin heavy chain on Western blots and fails to complement zip1 and zip2. Western blots also indicate zip2 fails to accumulate myosin heavy chain.
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_079136 NM_166704 NM_001014552 NM_001014553 NM_001202079 NM_001202080 NM_001202081 NM_001202082 NM_001259587 RefSeq (Proteins) • NP_523860 NP_726506 NP_001014552 NP_001014553 NP_001189008 NP_001189009 NP_001189010 NP_001189011 NP_001246516 DDBJ / EMBL / GenBank • AA391735 AA696049 AAA28713 AAB09048 AAB09049 AAB09050 AAB09051 AAF47311 AAF47311.1 AAM70805 AAM70805.1 AAX52687 AAX52688 AC006244 ADV37253 ADV37254 ADV37255 ADV37256 AFH08269 AI514025 AI541935 AQ024980 AQ025602 AX154688 CZ474631 CZ485506 CZ490293 M35012 U35816 Entrez Gene - A searchable database of RefSeq genes. • 38001 UniProtKB/Swiss-Prot • Q99323 UniProtKB/TrEMBL • Q59E58 Q59E59
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Myosin-like IQ motif-containing domain (IPR027401) P-loop containing nucleoside triphosphate hydrolase (IPR027417) IQ motif, EF-hand binding site (IPR000048) Myosin head, motor domain (IPR001609) Myosin tail (IPR002928) Myosin, N-terminal, SH3-like (IPR004009) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • PC00310
Linkouts
Synonyms & Secondary IDs ( 67 )
Reported As
Symbol Synonym	anon-WO0140519.37   CG15792 (Ni et al., 2010.12.1, Goldstein and Gunawardena, 2000, Rogers et al., 2003, Ni et al., 2011.7.19, Cammarato et al., 2011, Petzoldt et al., 2012) Dm nmII (Hodge and Cope, 2000) DmnmII (Yamashita et al., 2000) DROMHC (Schlotterer et al., 1998) Dronm-MII (Morgan, 1995) E(br) (Farkas and Mechler, 2000, Gotwals and Fristrom, 1991, ) l(2)17F1   l(2)02957 (Perrimon et al., 1996, ) MHC (Menon et al., 2005, Simone and DiNardo, 2008, Bertet et al., 2009, Laplante and Nilson, 2011) Mhc-c (Kiehart et al., 1991, Skaer, 1993, ) Mhc-c1   Myo (Lecuit and Wieschaus, 2000, Fox and Peifer, 2007, Choi et al., 2011, Tamada et al., 2012, Blankenship et al., 2006) Myo2 (Murthy et al., 2010) MyoII (Franke et al., 2007, Franke et al., 2005, Mlodzik, 2002, Simone, 2007, Pichaud et al., 2007, Pouille et al., 2009, Rodriguez-Diaz et al., 2008, Gettings et al., 2010, Bolinger et al., 2010, Robertson et al., 2012, Spahn et al., 2012) myoII (Grosshans et al., 2005, Morel et al., 2009, Bolinger et al., 2010) Myo II (Pichaud, 2007, Wei et al., 2005, Kaplan and Tolwinski, 2010) Myo-II (Fernandez-Sanchez et al., 2010, Bertet et al., 2009) Myo-II HC (Bertet et al., 2009) NMM (Dobens et al., 2005) nmMHC (Farkas et al., 2003, de Lorenzo et al., 1999, Farkas et al., 2006) NMMII (Seabrooke and Stewart, 2011) nmy-2 (Morris et al., 2000) unnamed (Halsell et al., 2000) Zip (Sen et al., 2012, Olguín et al., 2011, Simone and DiNardo, 2008, Kallappagoudar et al., 2010, Tamada et al., 2012, Carrasco-Rando and Ruiz-Gómez, 2008, Warner et al., 2010, Simões et al., 2010, Olguín et al., 2011, Tokusumi et al., 2012, Spahn et al., 2012) zip (Duboff et al., 2012, Franke et al., 2007, Weber et al., 2012, Gault et al., 2012, Japanese National Institute of Genetics, 2012.5.21, Escudero et al., 2011, Hammonds and Fristrom, 2006, Franke et al., 2006, Dilks and DiNardo, 2007, Winter et al., 2001, Hickson et al., 2006, Brodu and Casanova, 2006, Hawley and Gilliland, 2006, Jiang et al., 2011, Christensen et al., 2008.9.3, Farkas et al., 2007, Stuart et al., 2007, Todi et al., 2008, Chung et al., 2007, Buszczak et al., 2007, Kirchner et al., 2007, Kirchner et al., 2007, Gim et al., 2001, Okumura et al., 2008, Dietzl et al., 2007, Kaltenbach et al., 2007, Boettner and Van Aelst, 2007, Seabrooke and Stewart, 2011, Baek et al., 2010, Farkaš et al., 2011, Knowles-Barley et al., 2010, Rees et al., 2011, Axelsson et al., 2011, Chen et al., 2008, Kim et al., 2011, Sun et al., 2011, Escudero et al., 2007, Homem and Peifer, 2008, Pope and Harris, 2008, Fiehler and Wolff, 2007, Fiehler and Wolff, 2008, Verdier et al., 2006, Aerts et al., 2009, Zahedi et al., 2008, Rodriguez-Diaz et al., 2008, Dworkin et al., 2009, Warner and Longmore, 2009, Bertet et al., 2009, Landsberg et al., 2009, Patch et al., 2009, Chung et al., 2009, Campos et al., 2010, Gettings et al., 2010, David et al., 2010, Monier et al., 2010, Djiane and Mlodzik, 2010, Okumura et al., 2010, Neubueser and Hipfner, 2010, Simone and DiNardo, 2010, Saja et al., 2010, Martin et al., 2009, Franke et al., 2010, Simões et al., 2010, Neumüller et al., 2011, Kwon et al., 2010, Lowery et al., 2010, Rui et al., 2010, Sano et al., 2012, Guest et al., 2011) ZIP (Tang et al., 2011) zip/MyoII (Todi et al., 2008) zipper (Wirtz-Peitz and Knoblich, 2006) zpr (Foe et al., 1993)
Name Synonym	cytoplasmic myosin (Young et al., 1991) cytoplasmic myosin heavy chain (Fyrberg et al., 1988, Berrios et al., 1991) cytoplasmic myosin II (Zarnescu and Thomas, 1999, Field and Alberts, 1995) cytoplasmic myosin-II (Morgan, 1995) Enhancer of broad (Fristrom and Fristrom, 1993, Farkas and Mechler, 2000, ) lethal (2) 17F1   Myo-II heavy chain (Bertet et al., 2009) Myosin (Blankenship and Wieschaus, 2001, Swan et al., 2006, Wang and Riechmann, 2007, Fox and Peifer, 2007) myosin (Hunter and Wieschaus, 2000) myosin 2 (Koppen et al., 2006) Myosin-2 (Sokac and Wieschaus, 2008) Myosin 2 (Sokac and Wieschaus, 2008) Myosin HC (D'Avino et al., 2008) myosin heavy chain (OOta and Saitou, 1999, Menon et al., 2005, Hickson et al., 2006, Laplante and Nilson, 2011) Myosin heavy chain (Landgraf et al., 2003, Ahrens et al., 2007) Myosin Heavy Chain (Simone and DiNardo, 2008) Myosin heavy chain-cytoplasmic   myosin-heavy-chain-cytoplasmic   myosin II (Weber et al., 2012, Hardin and Walston, 2004, Bardin et al., 2004, Humbert et al., 2003, Somers and Saint, 2003, Nelson, 2003, Muller and Littlewood-Evans, 2001, Billuart et al., 2001, Phelps et al., 2001, Barros et al., 2001, Tzolovsky et al., 2001, Guild et al., 1999, Foe et al., 2000, Afshar et al., 2000, Field et al., 1999, Foe and Odell, 1999, Brill et al., 1998, Cramer et al., 1994, Rogers et al., 2003, Verni et al., 2004, Talbot and VanBerkum, 2006, Escudero et al., 2007, Koelsch and Leptin, 2008, Lecuit, 2004, Choi et al., 2011, Atwood and Prehoda, 2009, Bolinger et al., 2010, Pathak et al., 2010, Simões et al., 2010) Myosin II (Reed et al., 2012, Escudero et al., 2011, Nikolaidou and Barrett, 2005, Jacinto and Baum, 2003, Lecuit and Pilot, 2003, Tepass et al., 2001, Giansanti et al., 2001, Millo et al., 2004, Mulinari et al., 2007, Wei et al., 2005, Rogers et al., 2003, Straight et al., 2005, Szafer-Glusman et al., 2011, Blankenship et al., 2006, Fiehler and Wolff, 2007, Pouille et al., 2009, Serio et al., 2010, Uehara et al., 2010, Simone and DiNardo, 2010, Murthy et al., 2010, Driquez et al., 2011, Spahn et al., 2012, Haruta et al., 2010) Myosin-II (Barros et al., 2003, Lecuit et al., 2007, Bertet et al., 2009) Myosin II heavy chain (Gault et al., 2012, Mirouse et al., 2009) myosin II heavy chain (Betschinger et al., 2003, Ricketson et al., 2010) myosins II (Chia et al., 2008) non muscle myosin (Martin-Blanco et al., 1998) non-muscle myosin (Wei et al., 2003) nonmuscle myosin heavy chain (Young and Kiehart, 1991, Harden et al., 2002) non-muscle myosin heavy-chain (Sanny et al., 2006) non-muscle myosin II (Betschinger and Knoblich, 2004, Pichaud, 2007, Laplante and Nilson, 2006) Nonmuscle myosin-II (Baumann, 2001, Seabrooke et al., 2010) nonmuscle myosin II (Deng et al., 1999, Barros et al., 2003, Wei et al., 2005, Seabrooke and Stewart, 2011, Franke et al., 2010) non-muscle Myosin II (Pichaud et al., 2007) nonmuscle myosin-II heavy chain (Su and Kiehart, 2001, Bloor and Kiehart, 2001) non-muscle myosin II heavy chain (Rogers et al., 2004, Franke et al., 2007) nonmuscle Myosin II heavychain (Alves-Silva et al., 2008) zipper (Gault et al., 2012, Weber et al., 2012, Reed et al., 2012, Halsell and Kiehart, 1997, Riesgo-Escovar et al., 1996, Franke et al., 2006, Clark et al., 2006, Dilks and DiNardo, 2007, Texada et al., 2007, Hickson et al., 2006, Rogers et al., 2003, Hawley and Gilliland, 2006, Todi et al., 2008, Walters et al., 2006, Gim et al., 2001, Roy et al., 2008, Huang et al., 2003, Liu et al., 2008, Dean et al., 2005, Vielemeyer et al., 2010, Kaltenbach et al., 2007, Boettner and Van Aelst, 2007, Seabrooke and Stewart, 2011, Farkaš et al., 2011, Newman and Prehoda, 2009, Chen et al., 2008, Wang et al., 2006, Borghese et al., 2006, Escudero et al., 2007, Pope and Harris, 2008, Sokac and Wieschaus, 2008, Verdier et al., 2006, Pouille et al., 2009, Sawyer et al., 2009, Franke et al., 2007, Bassi et al., 2011, Landsberg et al., 2009, Campos et al., 2010, Gettings et al., 2010, Djiane and Mlodzik, 2010, Okumura et al., 2010, Simone and DiNardo, 2010, Laplante and Nilson, 2011, Franke et al., 2010, Cammarato et al., 2011, Cabernard et al., 2010, Ricketson et al., 2010, Lowery et al., 2010, Petzoldt et al., 2012, Guest et al., 2011) Zipper (Hickson et al., 2006, Fox and Peifer, 2007, Simone and DiNardo, 2008, Chia et al., 2008, Levayer et al., 2011, Blankenship et al., 2006, Grammont, 2007, Homem and Peifer, 2008, Fiehler and Wolff, 2007, D'Avino et al., 2008, Alves-Silva et al., 2008, Atwood and Prehoda, 2009, Carrasco-Rando and Ruiz-Gómez, 2008, Bertet et al., 2009, Warner et al., 2010, Murthy et al., 2010, Hatan et al., 2011, Olguín et al., 2011) Zipper heavy chain (Kaplan and Tolwinski, 2010)
Secondary FlyBase IDs
	FBgn0002742 FBgn0004415 FBgn0005634 FBgn0010524 FBgn0026658 FBgn0044594
References ( 415 )
Generate a list of	All references relating to this gene ( 415 )
List References by type	Research paper  ( 234 ) Supplementary material  ( 15 ) Review  ( 71 ) Erratum  ( 1 ) Personal communication to FlyBase  ( 17 ) Abstract  ( 67 ) FlyBase analysis  ( 2 ) Stock list  ( 2 ) Protein sequence record  ( 1 ) Website  ( 1 ) Curated genome annotation  ( 2 ) Patent  ( 1 ) Conference report  ( 1 )
Recent research papers ( 34 )
	Staller et al., 2013, Genetics 193(1): 51--61 Depleting Gene Activities in Early Drosophila Embryos with the "Maternal-Gal4-shRNA" System. [FBrf0220341] Abreu-Blanco et al., 2012, J. Cell Sci. 125(24): 5984--5997 Drosophila embryos close epithelial wounds using a combination of cellular protrusions and an actomyosin purse string. [FBrf0221131] Duboff et al., 2012, Neuron 75(4): 618--632 Tau Promotes Neurodegeneration via DRP1 Mislocalization In Vivo. [FBrf0219271] Gault et al., 2012, J. Cell Biol. 196(5): 605--621 Drosophila CK1-γ, gilgamesh, controls PCP-mediated morphogenesis through regulation of vesicle trafficking. [FBrf0217630] Majumder et al., 2012, Curr. Biol. 22(5): 363--372 Par-1 Controls Myosin-II Activity through Myosin Phosphatase to Regulate Border Cell Migration. [FBrf0217760] Petzoldt et al., 2012, Development 139(10): 1874--1884 DE-Cadherin regulates unconventional Myosin ID and Myosin IC in Drosophila left-right asymmetry establishment. [FBrf0218056] Reed et al., 2012, Cell. Microbiol. 14(4): 529--545 Rickettsia parkeri invasion of diverse host cells involves an Arp2/3 complex, WAVE complex and Rho-family GTPase-dependent pathway. [FBrf0217748] Robertson et al., 2012, Development 139(18): 3432--3441 Atonal and EGFR signalling orchestrate rok- and Drak-dependent adherens junction remodelling during ommatidia morphogenesis. [FBrf0219783] Ruggiero et al., 2012, PLoS Genet. 8(11): e1003049 Mitosis in Neurons: Roughex and APC/C Maintain Cell Cycle Exit to Prevent Cytokinetic and Axonal Defects in Drosophila Photoreceptor Neurons. [FBrf0220185] Sano et al., 2012, PLoS ONE 7(12): e52649 The Drosophila Actin Regulator ENABLED Regulates Cell Shape and Orientation during Gonad Morphogenesis. [FBrf0220491] Sen et al., 2012, J. Cell Biol. 199(4): 685--698 Drosophila PATJ supports adherens junction stability by modulating Myosin light chain activity. [FBrf0219897] Spahn et al., 2012, J. Cell Sci. 125(16): 3801--3812 The PDZ-GEF protein Dizzy regulates the establishment of adherens junctions required for ventral furrow formation in Drosophila. [FBrf0219682] Tamada et al., 2012, Dev. Cell 22(2): 309--319 Abl Regulates Planar Polarized Junctional Dynamics through β-Catenin Tyrosine Phosphorylation. [FBrf0217502] Tokusumi et al., 2012, PLoS ONE 7(7): e41604 Gene regulatory networks controlling hematopoietic progenitor niche cell production and differentiation in the Drosophila lymph gland. [FBrf0219204] Weber et al., 2012, Genetics 191(1): 145--162 Novel regulators of planar cell polarity: a genetic analysis in Drosophila. [FBrf0218210] Axelsson et al., 2011, BMC Bioinformatics 12: 342 Extracting quantitative genetic interaction phenotypes from matrix combinatorial RNAi. [FBrf0215222] Bassi et al., 2011, J. Cell Biol. 195(4): 595--603 Sticky/Citron kinase maintains proper RhoA localization at the cleavage site during cytokinesis. [FBrf0216679] Choi et al., 2011, Mol. Biol. Cell 22(12): 2010--2030 The single Drosophila ZO-1 protein Polychaetoid regulates embryonic morphogenesis in coordination with Canoe/afadin and Enabled. [FBrf0213894] Driquez et al., 2011, Phys. Biol. 8(6): 066007 Mechanotransduction in mechanically coupled pulsating cells: transition to collective constriction and mesoderm invagination simulation. [FBrf0216856] Escudero et al., 2011, Nat. Commun. 2: 526 Epithelial organisation revealed by a network of cellular contacts. [FBrf0218382] Farkaš et al., 2011, Nucleus 2(5): 489--499 Cytoskeletal proteins regulate chromatin access of BR-C transcription factor and Rpd3-Sin3A histone deacetylase complex in Drosophila salivary glands. [FBrf0216501] Guest et al., 2011, BMC Syst. Biol. 5(1): 65 A protein network-guided screen for cell cycle regulators in Drosophila. [FBrf0213913] Hatan et al., 2011, J. Cell Biol. 192(2): 307--319 The Drosophila blood brain barrier is maintained by GPCR-dependent dynamic actin structures. [FBrf0212807] Jiang et al., 2011, Oncogene 30(29): 3248--3260 Sds22/PP1 links epithelial integrity and tumor suppression via regulation of myosin II and JNK signaling. [FBrf0214488] Kim et al., 2011, Genes Dev. 25(7): 730--741 Psidin, a conserved protein that regulates protrusion dynamics and cell migration. [FBrf0213388] Laplante and Nilson, 2011, J. Cell Biol. 192(2): 335--348 Asymmetric distribution of Echinoid defines the epidermal leading edge during Drosophila dorsal closure. [FBrf0212838] Levayer et al., 2011, Nat. Cell Biol. 13(5): 529--540 Spatial regulation of Dia and Myosin-II by RhoGEF2 controls initiation of E-cadherin endocytosis during epithelial morphogenesis. [FBrf0213654] Neumüller et al., 2011, Cell Stem Cell 8(5): 580--593 Genome-Wide Analysis of Self-Renewal in Drosophila Neural Stem Cells by Transgenic RNAi. [FBrf0213621] Olguín et al., 2011, Curr. Biol. 21(3): 236--242 Intertissue mechanical stress affects frizzled-mediated planar cell polarity in the Drosophila notum epidermis. [FBrf0212947] Rees et al., 2011, Mol. Cell. Proteomics 10(6): M110.002386 In Vivo Analysis of Proteomes and Interactomes Using Parallel Affinity Capture (iPAC) Coupled to Mass Spectrometry. [FBrf0213845] Seabrooke and Stewart, 2011, J. Neurophysiol. 105(5): 1966--1976 Synaptic transmission and plasticity are modulated by nonmuscle myosin II at the neuromuscular junction of Drosophila. [FBrf0213748] Sun et al., 2011, Development 138(10): 1991--2001 Regulation of somatic myosin activity by Protein Phosphatase 1{beta} controls Drosophila oocyte polarization. [FBrf0213586] Szafer-Glusman et al., 2011, Mol. Biol. Cell 22(20): 3779--3790 Role of Survivin in cytokinesis revealed by a separation-of-function allele. [FBrf0216422] Tang et al., 2011, EMBO J. 30(4): 636--651 Atg1-mediated myosin II activation regulates autophagosome formation during starvation-induced autophagy. [FBrf0213047] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...