FlyBase Gene Report: Dmel\Cdc5

General Information

Symbol

Dmel\Cdc5

Species

D. melanogaster

Name

Cell division cycle 5

Annotation Symbol

CG6905

Feature Type

protein_coding_gene

FlyBase ID

FBgn0265574

Gene Model Status

Current

Stock Availability

10 publicly available

Gene Summary

Contribute a Gene Snapshot for this gene.

All Summaries

Alliance
Auto summary
Gene Group
Interactive Fly

Also Known As

cdc5-like

Key Links

Genomic Location

Cytogenetic map

61C1-61C1

Sequence location

3L:357,851..361,383 [-]

Recombination map

3-0.5

RefSeq locus

NT_037436 REGION:357851..361383

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (9 terms)

Molecular Function (3 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

enables DNA-binding transcription factor activity, RNA polymerase II-specific

inferred from biological aspect of ancestor with PANTHER:PTN000836844

(GO Reference Genome Project, 2011-)

enables RNA binding

inferred from sequence or structural similarity with HGNC:1743

(Gene Ontology Curators, 2002-)

enables RNA polymerase II transcription regulatory region sequence-specific DNA binding

inferred from biological aspect of ancestor with PANTHER:PTN000836844

(GO Reference Genome Project, 2011-)

Biological Process (2 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

involved_in mRNA splicing, via spliceosome

inferred from electronic annotation with InterPro:IPR047242

(InterPro Project Members, 2004-)

inferred from biological aspect of ancestor with PANTHER:PTN000067719

(GO Reference Genome Project, 2011-)

inferred from sequence or structural similarity with SGD:S000004826

(Mount and Salz, 2000)

inferred by curator from GO:0071011,GO:0071013

(Herold et al., 2009)

involved_in regulation of transcription by RNA polymerase II

inferred from biological aspect of ancestor with PANTHER:PTN000836844

(GO Reference Genome Project, 2011-)

Cellular Component (4 terms)

Terms Based on Experimental Evidence (3 terms)

CV Term

Evidence

References

part_of catalytic step 2 spliceosome

inferred from high throughput direct assay

(Herold et al., 2009)

part_of precatalytic spliceosome

inferred from high throughput direct assay

(Herold et al., 2009)

part_of Prp19 complex

inferred from direct assay

(Guilgur et al., 2014)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

part_of Prp19 complex

inferred from electronic annotation with InterPro:IPR047242

(InterPro Project Members, 2004-)

inferred from biological aspect of ancestor with PANTHER:PTN000067719

(GO Reference Genome Project, 2011-)

part_of spliceosomal complex

inferred from biological aspect of ancestor with PANTHER:PTN000067719

(GO Reference Genome Project, 2011-)

inferred from sequence or structural similarity with SGD:S000004826

(Mount and Salz, 2000)

Gene Group (FlyBase)

SPLICEOSOME COMPLEX B

SPLICEOSOME COMPLEX C

SPLICEOSOME COMPLEX P

SANT-MYB DOMAIN TRANSCRIPTION REGULATORS

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Group (FlyBase)

SPLICEOSOME COMPLEX B -: Nuclear pre-mRNA splicing is catalyzed by the spliceosome which assembles in a step-wise manner. After the assembly of complex A on pre-mRNA, the U4-U6 and U5 snRNPs are recruited as a preassembled tri-snRNP to form complex B. U5 snRNP binds exons at the 5' site. (Adapted from PMID:24452469 and PMID:23118483).
SPLICEOSOME COMPLEX C -: Nuclear pre-mRNA splicing is catalyzed by the spliceosome which assembles in a step-wise manner. Complex B undergoes a number of structural rearrangements and U4 and U1 snRNPs dissociate to generate complex C, the catalytic spliceosome. (Adapted from PMID:24452469 and PMID:23118483).
SPLICEOSOME COMPLEX P -: Nuclear pre-mRNA splicing is catalyzed by the spliceosome which assembles in a step-wise manner. Complex P, the post-spliceosomal complex, is formed after the catalytic removal of the intron by complex C. Complex P contains the lariat intron and spliced exons. (Adapted from PMID:24452469 and PMID:23118483).
SANT-MYB DOMAIN TRANSCRIPTION REGULATORS -: The SANT-MYB domain transcription regulators are essentially part of chromatin remodelling complexes and co-repressors. The SANT domain shows similarity with DNA-binding helix-turn-helix of Myb domain, and are involved in protein-protein interactions in the chromatin complexes. (Adapted from PMID:15040448).

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Cdc5 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9W0R0)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Antisense UTR: 3' UTR is antisense to Roc1b on opposite strand.

Gene model reviewed during 5.46

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Cdc5-RA

FBtr0072569

NM_138189

3346

814

Cdc5-RB

FBtr0300727

NM_001169842

3219

814

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

Cdc5-PA

FBpp0072468

93.1

814

8.46

FBpp0289951

93.1

814

8.46

Q9W0R0

NP_001163313

ACZ94585

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

814 aa isoforms: Cdc5-PA, Cdc5-PB

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Q9W0R0

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Cdc5 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Cdc5_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.03

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 4 -- 6

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 7 -- 8

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 9 -- 10

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 11 -- 12

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 13 -- 16

organism | ubiquitous

(Fisher et al., 2012)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

part_of catalytic step 2 spliceosome

inferred from high throughput direct assay

(Herold et al., 2009)

part_of precatalytic spliceosome

inferred from high throughput direct assay

(Herold et al., 2009)

part_of Prp19 complex

inferred from direct assay

(Guilgur et al., 2014)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Cdc5 in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Cdc5

View exonic expression by tissue for Dmel\Cdc5

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0265574

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

38062/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0265574

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0035136

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0265574

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG6905

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 1 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 8 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Cdc5

Transgenic constructs containing regulatory region of Cdc5

Aberrations (Deficiencies and Duplications) ( 1 )

Inferred from experimentation ( 1 )

Gene partially disrupted in

Df(3L)CRIMIC-CR70684

(Gene Disruption Project members, 2018-)

Inferred from location ( 6 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal, with Scer\GAL4^nub-AC-62

Cdc5^HMC02918

lethal, with Scer\GAL4^pnr-MD237

Cdc5^GD1575

lethal, with Scer\GAL4^tin.CΔ4

Cdc5^GD1575

lethal | female limited, with Scer\GAL4^dome-PG14

Cdc5^HMC02918

lethal - all die during larval stage, with Scer\GAL4^Mef2.PR

Cdc5^GD1575

lethal - all die during pupal stage, with Scer\GAL4^tin.CΔ4

Cdc5^GD1575

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Cdc5^GD1575

Sterility

Allele

female sterile, with Scer\GAL4^VP16.otu

Cdc5^HMC02918

Phenotype manifest in

Allele

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (7)

Hsap\CDC5L

14 of 14

Yes

2 of 14

2 of 14

2 of 14

1 of 14

Yes

Hsap\MYBL2

1 of 14

Hsap\TTF1

1 of 14

Yes

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (6)

Rnor\Cdc5l

14 of 14

Yes

Rnor\Mybl1

2 of 14

Rnor\Dmtf1

1 of 14

Yes

Rnor\Mybl2

1 of 14

Rnor\Myb

1 of 14

Rnor\Ttf1

1 of 14

Yes

Mus musculus (laboratory mouse) (15)

Mmus\Cdc5l

13 of 14

Yes

Mmus\Gm9040

11 of 14

Yes

Mmus\Gm9044

11 of 14

Yes

Mmus\Gm9046

11 of 14

Yes

Mmus\Gm9048

11 of 14

Yes

Mmus\Gm9049

11 of 14

Yes

Mmus\Gm32717

11 of 14

Yes

Mmus\Gm32802

11 of 14

Yes

Mmus\Gm9045

10 of 14

Yes

Mmus\Mybl1

2 of 14

Mmus\Myb

2 of 14

Mmus\Dmtf1l

1 of 14

Yes

Mmus\Dmtf1

1 of 14

Yes

Mmus\Mybl2

1 of 14

Mmus\Ttf1

1 of 14

Yes

Xenopus tropicalis (Western clawed frog) (4)

Xtro\cdc5l

8 of 13

Yes

Xtro\loxl4

1 of 13

Xtro\mybl2

1 of 13

Xtro\ndrg4

1 of 13

Danio rerio (Zebrafish) (7)

Drer\cdc5l

13 of 14

Yes

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

Yes

Drer\ttf1.6

1 of 14

Yes

Caenorhabditis elegans (Nematode, roundworm) (1)

Cele\cdc-5L

14 of 14

Yes

Anopheles gambiae (African malaria mosquito) (3)

Agam\AgaP_AGAP002954

12 of 12

Yes

Agam\AgaP_AGAP008160

2 of 12

Agam\AgaP_AGAP001156

1 of 12

Arabidopsis thaliana (thale-cress) (139)

Atha\CDC5

13 of 13

Yes

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

1 of 13

Yes

Atha\AT1G18960

1 of 13

Atha\AT1G43330

1 of 13

Yes

Atha\AT2G13960

1 of 13

Atha\AT5G34780

1 of 13

Atha\AT5G41020

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Atha\MYB11

1 of 13

Yes

Atha\MYB12

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Atha\MYB112

1 of 13

Atha\MYB113

1 of 13

Atha\MYB114

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Atha\MYBL2

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Saccharomyces cerevisiae (Brewer's yeast) (4)

Scer\CEF1

9 of 13

Yes

Scer\BAS1

1 of 13

Scer\NSI1

1 of 13

Scer\REB1

1 of 13

Schizosaccharomyces pombe (Fission yeast) (4)

Spom\cdc5

12 of 12

Yes

Spom\eta2

1 of 12

Yes

Spom\reb1

1 of 12

Yes

Spom\rtf1

1 of 12

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:Cdc5. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (2)

Myb

2 of 13

Pbp95

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Allele

Disease

Evidence

References

Cdc5^HMC04732

model of alcohol use disorder

CEA

(Petruccelli et al., 2020)

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Allele

Disease

Interaction

References

Cdc5^HMC04732

exacerbates cancer

modeled by Rbf^HMS03004

(Parkhitko et al., 2021)

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

CDC5L; cell division cycle 5 like

14 of 14

602868

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Show neighbor-neighbor interactions:

Off

Show/hide secondary interactors
(data from AllianceMine provided by esyN)

Select Layout:

Force Directed

Circle

Concentric

Legend:

Protein

RNA

Selected Interactor(s)

Other Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

Cdc5 - BCAS2

experimental knowledge based

(Guruharsha et al., 2011)

Cdc5 - CG8545

experimental knowledge based

(Guruharsha et al., 2011)

Cdc5 - Mfap1

anti bait coimmunoprecipitation, peptide massfingerprinting

(Andersen and Tapon, 2008)

Cdc5 - Prp19

anti tag coimmunoprecipitation, peptide massfingerprinting, anti bait coimmunoprecipitation, western blot

(Guilgur et al., 2014)

Cdc5 - Prp38

anti bait coimmunoprecipitation, peptide massfingerprinting

(Andersen and Tapon, 2008)

Cdc5 - RasGAP1

anti tag coimmunoprecipitation, peptide massfingerprinting

(Friedman et al., 2011)

Cdc5 - Rs1

experimental knowledge based

(Guruharsha et al., 2011)

Cdc5 - S6kII

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Cdc5 - Tango4

experimental knowledge based

(Guruharsha et al., 2011)

Cdc5 - Tsc1

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Cdc5 - fand

anti tag coimmunoprecipitation, peptide massfingerprinting

(Guilgur et al., 2014)

Cdc5 - foxo

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Cdc5 - gig

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Cdc5 - sima

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Summary of Genetic Interactions

esyN Network Diagram

Other Interaction Browsers

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0265574

MIST (protein-protein) - An integrated Molecular Interaction Database

38062

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Spliceosome

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

mRNA Splicing - Major Pathway

Class of Gene

gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-0.5

Cytogenetic map

61C1-61C1

Sequence location

3L:357,851..361,383 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

61C1-61C1

Limits computationally determined from genome sequence between P{PZ}trh¹⁰⁵¹² and P{EP}EP3104^EP3104

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

3-0.5

(FlyBase, 2016)

3-0.1

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (10)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

66585

w¹¹¹⁸; P{Cdc5-GFP.FPTB}attP40

28464

w^*; P{EP}Cdc5^G4210/TM6B, Tb¹

80425

y¹ v¹; P{TRiP.HMS06005}attP2/TM3, Sb¹

82764

y¹ sc^* v¹ sev²¹; P{TOE.GS05196}attP40

55261

y¹ sc^* v¹ sev²¹; P{TRiP.HMC03948}attP40

57425

y¹ sc^* v¹ sev²¹; P{TRiP.HMC04732}attP40

44524

y¹ sc^* v¹ sev²¹; P{TRiP.HMC02918}attP2/TM3, Sb¹

NIG-Fly

HMC02918

y¹ sc^* v¹ sev²¹; P{TRiP.HMC02918}attP2/TM3, Sb¹

VDRC

v109369

P{KK115607}VIE-260B

v13492

w¹¹¹⁸; P{GD1575}v13492

Genomic Clones (9)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (128)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

LD21614

Other clones

DPiM_LD21614

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0265574

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Identified as a potential component of the hh signalling pathway in a genome-wide RNAi screen. dsRNA made from templates generated with primers directed affects the extent of expression of a hh signaling reporter construct in Clone 8 cells.

(Nybakken et al., 2005)

Relationship to Other Genes

Source for database merge of

Source for merge of: cdc5 CG6905

(Ohi et al., 1998)

Additional comments

Nomenclature History

Source for database identify of

Nomenclature comments

Etymology

Synonyms and Secondary IDs (8)

Reported As

Symbol Synonym

CG6905

(Kolkhof et al., 2017, Hosono et al., 2015, Rosa-Ferreira et al., 2015, Guilgur et al., 2014, Neumüller et al., 2013, Friedman et al., 2011, Neumüller et al., 2011, Müller et al., 2010, Müller et al., 2010, Ni et al., 2010.12.1, Herold et al., 2009, Keleman et al., 2009.8.5, Perkins et al., 2009, Andersen and Tapon, 2008, Nybakken et al., 2005)

Cdc5

(Lee et al., 2024, Zhao et al., 2023, Repton et al., 2022, Kao et al., 2021, Klann et al., 2021, Parkhitko et al., 2021, Sureka and Mishra, 2021, Tsui et al., 2018, Housden et al., 2017, Transgenic RNAi Project members, 2017-)

Cdc5Dm

(Ohi et al., 1998)

cdc5

cdc5-like

(Herold et al., 2009)

cef1

(Andersen and Tapon, 2008)

Name Synonyms

Cell division cycle 5

Cell division cycle 5 ortholog

cdc5

cdc5-like

(Guilgur et al., 2014)

Secondary FlyBase IDs

FBgn0035136
FBgn0025183

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 37 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

38062

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9W0R0

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Q9W0R0

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9W0R0

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0265574

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

38062/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0265574

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0265574

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG6905

MARRVEL_MODEL - MARRVEL (model organism gene)

38062

Linkouts

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0265574

DroID - A comprehensive database of gene and protein interactions.

FBgn0265574

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Cdc5_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0035136

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0265574

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG6905

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0265574

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC011382

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Spliceosome

MIST (protein-protein) - An integrated Molecular Interaction Database

38062

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

mRNA Splicing - Major Pathway

References (68)

The following external sites may use different assemblies or annotations than FlyBase.

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