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Gene Dmel\beat-IIIa

General Information
Symbol	Dmel\beat-IIIa	Species	D. melanogaster
Name	beat-IIIa	Annotation symbol	CG12621
Feature type	protein_coding_gene	FlyBase ID	FBgn0265607
Gene Model Status	Current	Stock availability	4 publicly available
Genomic Location
Chromosome (arm)	2L	Recombination map
Cytogenetic map	36C2-36C2	Sequence location	2L:17,131,024..17,173,118 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene beat-IIIa is referred to in FlyBase by the symbol Dmel\beat-IIIa (CG12621, FBgn0265607). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. Based on sequence similarity, it is predicted to be involved in the biological process: heterophilic cell-cell adhesion. One allele is reported. The phenotype of this allele is annotated with: trichogen cell. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Immunoglobulin V-set; Immunoglobulin subtype; Immunoglobulin-like domain; Immunoglobulin-like fold. Gene sequence location is 2L:17131024..17173118.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02	New/Merged/Split Record This record was either newly added to FlyBase for this release or is the result of merging or splitting existing records in this release
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 36C2-36C2
Experimentally Determined Cytological Location
Cytogenetic map Notes References 36B2-36B2     (Pipes, 2001.8.23)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\beat-IIIa for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.50 Gene model reviewed during 5.51 Transposon inserted in intron gene_with_dicistronic_mRNA ; SO:0000722
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) beat-IIIa-RD FBtr0303301  NM_001201899   1459   343 beat-IIIa-RE FBtr0340178     4457   343
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein beat-IIIa-PD   FBpp0292391   38.6   343   9.04     NP_001188828   ADV37077 beat-IIIa-PE   FBpp0309161   38.6   343   9.04
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Immunoglobulin subtype (IPR003599) Immunoglobulin-like domain (IPR007110) Immunoglobulin V-set (IPR013106) Immunoglobulin-like fold (IPR013783)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014134 ADV37077   AY052379 AAL13088   BT030424   BT058091   BT125644   BT132802   CO192383   CO274956   CO315946   CO342741   EC231964   EC257276   EL886376   EL886423
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	E1JHJ8 Q95UI4 Q9VJF3
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References regulatory region FBsf0000435909 2L:17,140,480..17,141,559 evidence=Reporter construct (in vivo) (Halfon et al., 2011, Halfon, 2012.6.19)
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
[an error occurred while processing this directive] FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
[an error occurred while processing this directive]
modENCODE Development RNA-Seq
[an error occurred while processing this directive] modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
[an error occurred while processing this directive]
modENCODE Treatments RNA-Seq
[an error occurred while processing this directive]
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_14 mE1_20_mRNA_expression_cluster_13
External Data & Images
Linkouts
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 beat-IIIaGD15037 Other Phenotypes Allele visible, with Scer\GAL4pnr-MD237 beat-IIIaGD15037 Phenotype manifest in Allele trichogen cell, with Scer\GAL4pnr-MD237 beat-IIIaGD15037
Classical Alleles ( 0 )
For All Classical Alleles Show
Allele of beat-IIIa Class Mutagen Stocks Known lesion
Alleles Carried on Transgenic Constructs ( 1 )
For All Alleles Carried on Transgenic Constructs Show
Allele of beat-IIIa Class Mutagen Stocks Known lesion beat-IIIaGD15037 in vitro construct - RNAi in vitro construct - regulatory fusion 4 Yes
Aneuploid Aberrations
Disrupted in	Df(2L)Exel8036 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD15037} NA
Insertions
	Type of insertions Name Expression data
Gene Ontology: Function, Process & Cellular Component ( 2 unique terms )
	There is no information supporting a molecular function term for this gene. (Based on a review of available data on: 2013-02-14)
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 2 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
heterophilic cell-cell adhesion inferred from sequence or structural similarity with beat-Ic (Pipes et al., 2001)
Cellular Component
CV term Evidence References
extracellular region non-traceable author statement (Pipes, 2001.8.23)
Sequence Ontology: Class of Gene
	gene_with_dicistronic_mRNA (FlyBase Genome Annotators, 2013) nuclear_gene (FlyBase Genome Annotators, 2010) protein_coding_gene (FlyBase Genome Annotators, 2010)
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions beat-IIIa allele Gene References
External Data
Linkouts
Orthologs
OrthoDB Orthologs (53) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6S1TTF Dipteran inclusive ortholog search EOG6640MS Insect inclusive ortholog search EOG60K6VM Arthropod inclusive ortholog search EOG6NVX24 Metazoa inclusive ortholog search No orthologs identified
Orthologs in Drosophila Species (EOG6S1TTF)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\beat-IIIa     Drosophila simulans   Dsim\GD24100 Y Y Drosophila sechellia   Dsec\GM17225 Y Y Drosophila erecta   Dere\GG21074 Y Y Drosophila yakuba   Dyak\GE12783 Y Y Drosophila pseudoobscura pseudoobscura   Dpse\GA11722 Y Y Drosophila persimilis   Dper\GL22397 Y Y Drosophila willistoni   Dwil\GK23799 Y Y Drosophila virilis   Dvir\GJ16186 Y Y Drosophila mojavensis   Dmoj\GI17146 Y Y Drosophila grimshawi   Dgri\GH11700 Y Y
Orthologs in non-Drosophila Dipterans (EOG6640MS)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL002692 Y Aedes aegypti Yellow fever mosquito  Aaeg\AAEL002690 Y Anopheles gambiae Malaria mosquito  Agam\AGAP007932 Y Anopheles gambiae Malaria mosquito  Agam\AGAP007933 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ015756 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ015755 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ802281 Y
Orthologs in non-Dipteran Insects (EOG60K6VM)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB43851 Y Apis mellifera Western honey bee  Amel\GB43885 Y Apis mellifera Western honey bee  Amel\GB43887 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG015717 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG015725 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH15928 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH12883 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH12876 Y Atta cephalotes Leafcutter ant  Acep\ACEP14613 Y Atta cephalotes Leafcutter ant  Acep\ACEP21973 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO20970 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO20985 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO20969 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL14681 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL14670 Y Linepithema humile Argentine ant  Lhum\LH17615 Y Linepithema humile Argentine ant  Lhum\LH17628 Y Linepithema humile Argentine ant  Lhum\LH17617 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB20219 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB20214 Y Solenopsis invicta Red fire ant  Sinv\SINV11751 Y Solenopsis invicta Red fire ant  Sinv\SINV12993 Y Solenopsis invicta Red fire ant  Sinv\SINV11749 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI001531 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI003999 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI006851 Y Bombyx mori Silkmoth  Bmor\BGIBMGA010346 Y Pediculus humanus Human body louse  Phum\PHUM610960 Y Pediculus humanus Human body louse  Phum\PHUM336810 Y Tribolium castaneum Red flour beetle  Tcas\beat-IIIc Y
Orthologs in non-Insect Arthropods (EOG6NVX24)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\JGI_V11_253895 Y Daphnia pulex Water flea  Dpux\JGI_V11_63749 Y Daphnia pulex Water flea  Dpux\GPATCH3 Y Ixodes scapularis Deer tick  Isca\ISCW008169 Y Ixodes scapularis Deer tick  Isca\ISCW009755 Y
Orthologs in non-Arthropod Metazoa (None identified)
No non-Arthropod Metazoa orthologies identified
Human Orthologs (0)
Gene OMIM HGNC
AAA Orthologs (10) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD24100 Drosophila sechellia Dsec\GM17225 Drosophila erecta Dere\GG21074 Drosophila yakuba Dyak\GE12783 Drosophila pseudoobscura pseudoobscura Dpse\GA11722 Drosophila persimilis Dper\GL22397 Drosophila willistoni Dwil\GK23799 Drosophila virilis Dvir\GJ16186 Drosophila mojavensis Dmoj\GI17146 Drosophila grimshawi Dgri\GH11700
Stocks & Reagents
Stocks Listed in FlyBase ( 4 )
VDRC	v29655 w1118 P{GD15037}v29655 v45866 w1118; P{GD15037}v45866 v45865 w1118; P{GD15037}v45865/CyO v46258 w1118; P{GD15037}v46258/TM3
Genomic Clones ( 1 )
	BACR07G13 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 11 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones
Other clones	FI16832 IP17713 MIP04048 RT09993
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones
Other clones	214339.30 CK01.142D.H3 EC33614 EK116030 EK263201 EP15431 IP17613
RNAi & Array Information
Linkouts
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: beat-IIIa CG12621 (FlyBase, 1996-)
Source for database merge of	Source for merge of: beat-IIIa CG42757 (FlyBase Genome Annotators, 2013)
Additional comments	One or more of the processed transcripts for these genes contain two non-overlapping open reading frames (ORFs). The non-overlapping ORFs are represented by CG12621 (beat-IIIa, FBgn0265607) and CG34106 (FBgn0083942). (FlyBase Genome Annotators, 2013) Annotations CG12621 and CG42757 merged as CG12621 in release 5.50 of the genome annotation; CG42757 corresponds to the 3' UTR of CG12621. Merge based on cDNA and RNA-Seq expression data. (FlyBase Genome Annotators, 2013) Source for identity of beat-IIIa CG12621 was sequence comparison (date:011019). (FlyBase, 1996-)
Other Comments
	New annotation (CG42757) in release 5.28 of the genome annotation. (FlyBase Genome Annotators, 2010)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_001201899 RefSeq (Proteins) • NP_001188828 DDBJ / EMBL / GenBank • AAF53596 AAL13088 ACZ94281 ADV37077 ADV37078 AY052379 Entrez Gene - A searchable database of RefSeq genes. • 35035 10178887 UniProtKB/TrEMBL • E1JHJ8 Q9VJF3 Q95UI4
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Immunoglobulin subtype (IPR003599) Immunoglobulin-like domain (IPR007110) Immunoglobulin V-set (IPR013106) Immunoglobulin-like fold (IPR013783)
Linkouts
Synonyms & Secondary IDs ( 4 )
Reported As
Symbol Synonym	beat-IIIa (FlyBase Genome Annotators, 2013, Halfon et al., 2011, Bellen et al., 2011, FlyBase Genome Annotators, 2013) beat IIIa (Pipes et al., 2001) CG12621   CG42757 (FlyBase Genome Annotators, 2010)
Name Synonym	beat-IIIa
Secondary FlyBase IDs
	FBgn0032627 FBgn0261815
References ( 19 )
Research paper	Bellen et al., 2011, Genetics 188(3): 731--743 The Drosophila gene disruption project: progress using transposons with distinctive site specificities. [FBrf0214229] Halfon et al., 2011, BMC Genomics 12: 578 Erroneous attribution of relevant transcription factor binding sites despite successful prediction of cis-regulatory modules. [FBrf0217986] Vogel et al., 2003, Development 130(25): 6317--6328 The immunoglobulin superfamily in Drosophila melanogaster and Caenorhabditis elegans and the evolution of complexity. [FBrf0167517] Pipes et al., 2001, Development 128(22): 4545--4552 The Beat generation: a multigene family encoding IgSF proteins related to the Beat axon guidance molecule in Drosophila. [FBrf0141485]
Supplementary material	Graveley et al., 2011, Nature 471(7339): Supplementary Table 33. Fuzzy Cluster Members. [FBrf0213980] The modENCODE Consortium, 2010, Science 330(6012): DataS14: Gene co-expression clusters. [FBrf0213979] Mummery-Widmer et al., 2009, Nature 458(7241): Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518] Giot et al., 2003, Science 302(5651): Tables S1 to S7. [FBrf0166452]
Personal communication to FlyBase	Halfon, 2012.6.19, REDfly CRMs and TFBS as mapped FlyBase features. REDfly CRMs and TFBS as mapped FlyBase features. [FBrf0218775] Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327] Ryder, 2004.4.26, Exelixis CG deletion data. Exelixis CG deletion data. [FBrf0184335]
FlyBase analysis	FlyBase Genome Annotators, 2013, Changes affecting gene model number or type in release 5.50 of the annotated D.melanogaster genome. Changes affecting gene model number or type in release 5.50 of the annotated D.melanogaster genome. [FBrf0220306] FlyBase Genome Annotators, 2013, Changes affecting gene model number or type in release 5.51 of the annotated D.melanogaster genome. Changes affecting gene model number or type in release 5.51 of the annotated D.melanogaster genome. [FBrf0220804] FlyBase Genome Annotators, 2010, Changes affecting gene model number or type in release 5.28 of the annotated D.melanogaster genome. Changes affecting gene model number or type in release 5.28 of the annotated D.melanogaster genome. [FBrf0210498] FlyBase Curators, 2002-, Use of the ND evidence code for Gene Ontology (GO) terms in FlyBase. Use of the ND evidence code for Gene Ontology (GO) terms in FlyBase. [FBrf0159398] FlyBase, 1996-, FlyBase inference based on genome sequence analysis. FlyBase inference based on genome sequence analysis. [FBrf0104946] FlyBase, 1992-, FlyBase curation. FlyBase curation. [FBrf0105495]
DNA/RNA sequence record	Pipes, 2001.8.23, GenBank/EMBL/DDBJ: AY052379 Drosophila melanogaster Beat IIIa mRNA, partial cds. [FBrf0140102]
Curated genome annotation	FamiliarityBreedsContempt, 1999.11, [Automatic annotations performed at the Celera Jamboreee.] [Automatic annotations performed at the Celera Jamboreee.] [FBrf0126705]