General Information
Symbol
Dmel\Su(z)2
Species
D. melanogaster
Name
Suppressor of zeste 2
Annotation Symbol
CG3905
Feature Type
FlyBase ID
FBgn0265623
Gene Model Status
Stock Availability
Gene Snapshot
Suppressor of zeste 2 regulates gene expression by modifying epigenetic marks. The gene is related to Psc and was orginally identified due to its ability to suppress transvection at z. [Date last reviewed: 2016-06-23]
Also Known As
Arp, Su(z)2D, Su(z)3, l(2)k06344
Genomic Location
Cytogenetic map
Sequence location
2R:12,996,501..13,007,911 [+]
Recombination map
2-67
Sequence
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
GO Summary Ribbons
Families, Domains and Molecular Function
Gene Group Membership (FlyBase)
Protein Family (UniProt, Sequence Similarities)
-
Molecular Function (see GO section for details)
Summaries
Gene Group Membership
RING FINGER DOMAIN PROTEINS -
The RING (Really Interesting New Gene) finger domain co-ordinates two Zn2+ ions via conserved Cys and His residues. Most proteins which contain a RING finger are assumed to be ubiquitin (E3) ligases. The RING finger binds ubiquitin-conjugating enzymes (E2) and promotes direct transfer of ubiquitin to the target protein. (Adapted from FBrf0215242 and PMID:19489725).
UniProt Contributed Function Data
Regulates expression of the homeotic selector genes by influencing higher-order chromatin structure through interaction with other proteins.
(UniProt, P25172)
Phenotypic Description from the Red Book (Lindsley and Zimm 1992)
Arp: Aristapedioid (P. Adler)
Homozygous lethal. Two dramatic dominant phenotypes: One is a partial transformation of arista to tarsus, the other is the loss or reduction in size of medially located macrochaetae on the dorsal thorax. Both phenotypes show high penetrance but variable expressivity.
Su(z)2: Suppressor 2 of zeste
Dominant suppressor of the yellow eye color associated with the z1 mutation. Can be detected in homozygous z1 females and in males. Lethal in homozygous or hemizygous condition and in trans-allelic heterozygotes. Viability reduced in trans heterozygotes in some Psc/Su(z)2 combinations, lethal in others. Psc and Su(z)2 are both members of the Su(z)2 complex.
Gene Model and Products
Number of Transcripts
3
Number of Unique Polypeptides
2

Please see the GBrowse view of Dmel\Su(z)2 or the JBrowse view of Dmel\Su(z)2 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model
Stop-codon suppression (UAG) postulated; FBrf0216884
gene_with_stop_codon_read_through ; SO:0000697
Gene model reviewed during 5.44
Gene model reviewed during 5.49
Gene model reviewed during 5.56
Sequence Ontology: Class of Gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
FBtr0087793
6301
1368
FBtr0300387
6631
1368
FBtr0330613
6522
1396
Additional Transcript Data and Comments
Reported size (kB)
6.3 (longest cDNA)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
FBpp0086906
146.4
1368
9.87
FBpp0289616
146.4
1368
9.87
FBpp0303463
149.5
1396
9.80
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

1368 aa isoforms: Su(z)2-PA, Su(z)2-PB
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Su(z)2 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Gene Ontology (11 terms)
Molecular Function (4 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
inferred from direct assay
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
inferred from electronic annotation with InterPro:IPR018957
(assigned by InterPro )
inferred from biological aspect of ancestor with PANTHER:PTN000850589
(assigned by GO_Central )
inferred from sequence model
Biological Process (4 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
inferred from direct assay
inferred from mutant phenotype
(assigned by UniProt )
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
inferred from biological aspect of ancestor with PANTHER:PTN000850589
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN000850589
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN000850589
(assigned by GO_Central )
Cellular Component (3 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
inferred from direct assay
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
inferred from biological aspect of ancestor with PANTHER:PTN000850589
(assigned by GO_Central )
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
inferred from direct assay
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Su(z)2 in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Alleles, Insertions, Transgenic Constructs and Phenotypes
Classical and Insertion Alleles ( 67 )
For All Classical and Insertion Alleles Show
 
Allele of Su(z)2
Class
Mutagen
Associated Insertion
Stocks
Known lesion
Other relevant insertions
insertion of mobile activating element
miscellaneous insertions
Name
Expression Data
Transgenic Constructs ( 18 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Su(z)2
Allele of Su(z)2
Mutagen
Associated Transgenic Construct
Stocks
Transgenic constructs containing regulatory region of Su(z)2
Deletions and Duplications ( 38 )
Summary of Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
Sterility
Allele
Other Phenotypes
Allele
Phenotype manifest in
Allele
abdomen & macrochaeta
costal vein & macrochaeta
dorsal double row & macrochaeta
dorsal triple row & macrochaeta
head & macrochaeta
leg & macrochaeta
scutellum & macrochaeta
scutum & macrochaeta
thorax & macrochaeta
ventral double row & macrochaeta
ventral triple row & macrochaeta
Orthologs
Human Orthologs (via DIOPT v7.1)
Homo sapiens (Human) (9)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
6 of 15
Yes
Yes
5 of 15
No
No
3 of 15
No
No
3 of 15
No
Yes
3 of 15
No
No
2 of 15
No
No
2 of 15
No
No
1 of 15
No
Yes
1 of 15
No
Yes
Model Organism Orthologs (via DIOPT v7.1)
Mus musculus (laboratory mouse) (8)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
6 of 15
Yes
No
 
5 of 15
No
Yes
3 of 15
No
Yes
3 of 15
No
No
2 of 15
No
No
2 of 15
No
No
1 of 15
No
Yes
1 of 15
No
Yes
Rattus norvegicus (Norway rat) (11)
6 of 13
Yes
Yes
6 of 13
Yes
Yes
4 of 13
No
Yes
2 of 13
No
Yes
2 of 13
No
Yes
2 of 13
No
No
2 of 13
No
Yes
2 of 13
No
No
1 of 13
No
Yes
1 of 13
No
Yes
1 of 13
No
No
Xenopus tropicalis (Western clawed frog) (6)
5 of 12
Yes
No
4 of 12
No
Yes
1 of 12
No
Yes
1 of 12
No
Yes
1 of 12
No
No
1 of 12
No
Yes
Danio rerio (Zebrafish) (8)
6 of 15
Yes
No
6 of 15
Yes
No
2 of 15
No
Yes
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
1 of 15
No
Yes
1 of 15
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (2)
2 of 15
Yes
No
1 of 15
No
No
Arabidopsis thaliana (thale-cress) (5)
1 of 9
Yes
No
1 of 9
Yes
Yes
1 of 9
Yes
No
1 of 9
Yes
No
1 of 9
Yes
Yes
Saccharomyces cerevisiae (Brewer's yeast) (1)
1 of 15
Yes
Yes
Schizosaccharomyces pombe (Fission yeast) (1)
1 of 12
Yes
Yes
Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG091901NJ )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila melanogaster
fruit fly
Drosophila suzukii
Spotted wing Drosophila
Drosophila simulans
Drosophila sechellia
Drosophila erecta
Drosophila yakuba
Drosophila ananassae
Drosophila pseudoobscura pseudoobscura
Drosophila persimilis
Drosophila willistoni
Drosophila virilis
Drosophila grimshawi
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091500TY )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Glossina morsitans
Tsetse fly
Lucilia cuprina
Australian sheep blowfly
Lucilia cuprina
Australian sheep blowfly
Aedes aegypti
Yellow fever mosquito
Culex quinquefasciatus
Southern house mosquito
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( None identified )
No non-Dipteran orthologies identified
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X00MC )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Tetranychus urticae
Two-spotted spider mite
Tetranychus urticae
Two-spotted spider mite
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G09IB )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Ciona intestinalis
Vase tunicate
Ciona intestinalis
Vase tunicate
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Human Disease Model Data
FlyBase Human Disease Model Reports
Alleles Reported to Model Human Disease (Disease Ontology)
Download
Models ( 0 )
Allele
Disease
Evidence
References
Interactions ( 3 )
Allele
Disease
Interaction
References
Comments ( 0 )
 
Human Orthologs (via DIOPT v7.1)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Functional Complementation Data
Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
Interactions
Summary of Physical Interactions
Summary of Genetic Interactions
esyN Network Diagram
esyN Network Key:
Suppression
Enhancement

Please look at the allele data for full details of the genetic interactions
Starting gene(s)
Interaction type
Interacting gene(s)
Reference
Starting gene(s)
Interaction type
Interacting gene(s)
Reference
External Data
Linkouts
DroID - A comprehensive database of gene and protein interactions.
Pathways
Gene Group - Pathway Membership (FlyBase)
External Data
Linkouts
Genomic Location and Detailed Mapping Data
Chromosome (arm)
2R
Recombination map
2-67
Cytogenetic map
Sequence location
2R:12,996,501..13,007,911 [+]
FlyBase Computed Cytological Location
Cytogenetic map
Evidence for location
49E7-49E7
Left limit from non-inclusion within Df(2R)vg-C (FBrf0082794) Right limit from inclusion within Df(2R)Su(z)3-1.jtg (FBrf0082794)
Experimentally Determined Cytological Location
Cytogenetic map
Notes
References
49E6-49E7
(determined by in situ hybridisation)
49A12-49B3
(determined by in situ hybridisation)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
2-67.3 or 2-68.7 or 2-66.0 Mapping based on Su(z)21. Mapping based on Su(z)25.
Mapping based on Su(z)31. Mapping based on Su(z)3eos.
Su(z)2 maps very close to vg.
Stocks and Reagents
Stocks (32)
Genomic Clones (24)
cDNA Clones (25)
 

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequences
BDGP DGC clones
Other clones
    Drosophila Genomics Resource Center cDNA clones

    For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

    cDNA Clones, End Sequenced (ESTs)
    BDGP DGC clones
      RNAi and Array Information
      Linkouts
      GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
      Antibody Information
      Laboratory Generated Antibodies
       
      Commercially Available Antibodies
       
      Other Information
      Relationship to Other Genes
      Source for database identify of
      Source for database merge of
      Source for merge of: Su(z)2 l(2)k06344
      Source for merge of: Su(z)2 Su(z)3
      Additional comments
      Other Comments
      RNAi generated by PCR using primers directed to this gene causes a cell growth and viability phenotype when assayed in Kc167 and S2R+ cells.
      Mutations in Su(z)2 suppress telomeric Position Effect Variegation (PEV) on the second and third chromosomes, but not on the fourth chromosome.
      Deletion analysis of the protein reveals the homology region (HR) is necessary and sufficient for Su(z)2 locus specific polytene chromosome binding.
      l(3)73Ah amino acid sequence comparison reveals homology to the zinc-finger containing N-terminal domain of Psc and Su(z)2.
      Mosaic and expression pattern analysis reveals that the Pc-group genes do not act only in a common complex or pathway: they must have some independent functions.
      The mutant phenotypes of Psc, Su(z)2 and Su(z)3, the similarities of the phenotypes and the mutational interactions between them suggest that the products are functionally similar and act at the level of chromatin, possibly as a multimeric complex.
      Members of the Pc group function as potent repressors in mammalian cells.
      Su(z)2 is one of several Pc-G genes required for the repression of gap genes by maternally supplied hb product.
      Psc and Su(z)2 gene products are nuclear proteins and are associated with more than 80 sites in the salivary gland polytene chromosomes. There is considerable overlap with the sites that are bound by antibodies to z, Pc and the polyhomeotic proteins. This association of the Psc and Su(z)2 proteins with the chromosomes is dependent on the presence of active E(z) protein.
      Su(z)2 alleles are dominant suppressors of the yellow eye color associated with the z1 mutation. Can be detected in homozygous z1 females and in males. Lethal in homozygous or hemizygous condition and in trans-allelic heterozygotes. Viability reduced in transheterozygotes in some Psc1/Su(z)2 combinations, lethal in others.
      The "Aristapedioid" mutant phenotype results from the juxtaposition of unrelated DNA with Su(z)2, causing a gain of function mutation.
      Origin and Etymology
      Discoverer
      Etymology
      Identification
      External Crossreferences and Linkouts ( 35 )
      Crossreferences
      NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
      GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
      GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
      RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
      UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
      UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
      Linkouts
      ApoDroso - Functional genomic database for photoreceptor development, survival and function
      Drosophila Genomics Resource Center - Drosophila Genomics Resource Center cDNA clones
      DroID - A comprehensive database of gene and protein interactions.
      Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
      GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
      Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
      KEGG Genes - Molecular building blocks of life in the genomic space.
      Synonyms and Secondary IDs (25)
      Reported As
      Symbol Synonym
      Name Synonyms
      Aristopedoid
      Suppressor of Zeste 3
      Suppressor of zeste (2)
      Suppressor of zeste (3)
      Suppressor of zeste 3
      Suppressor two of Zeste
      Supressor of zeste 2
      suppressor of zeste two
      Secondary FlyBase IDs
      • FBgn0008654
      • FBgn0000118
      • FBgn0022134
      • FBgn0003645
      Datasets (0)
      Study focus (0)
      Experimental Role
      Project
      Project Type
      Title
      References (225)