Suppressor 2 of zeste, Su(z)2D, Arp, Su(z)3, Suppressor of zeste two
transcription factor - zinc finger - ring motif - chromatin associated protein - Su(Z)2 and Psc proteins co-localize to and silence many of the same chromosomal loci acted upon by other Pc-G proteins, suggesting that Pc-G proteins function in a multi-protein complex to maintain gene silencing
Stop-codon suppression (UAG) postulated; FBrf0216884
Gene model reviewed during 5.44
Gene model reviewed during 5.49
Gene model reviewed during 5.56
6.3 (longest cDNA)
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Su(z)2 using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signalsView Dmel\Su(z)2 in GBrowse 2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
RNAi generated by PCR using primers directed to this gene causes a cell growth and viability phenotype when assayed in Kc167 and S2R+ cells.
Mutations in Su(z)2 suppress telomeric Position Effect Variegation (PEV) on the second and third chromosomes, but not on the fourth chromosome.
Deletion analysis of the protein reveals the homology region (HR) is necessary and sufficient for Su(z)2 locus specific polytene chromosome binding.
Mosaic and expression pattern analysis reveals that the Pc-group genes do not act only in a common complex or pathway: they must have some independent functions.
The mutant phenotypes of Psc, Su(z)2 and Su(z)3, the similarities of the phenotypes and the mutational interactions between them suggest that the products are functionally similar and act at the level of chromatin, possibly as a multimeric complex.
Members of the Pc group function as potent repressors in mammalian cells.
Psc and Su(z)2 gene products are nuclear proteins and are associated with more than 80 sites in the salivary gland polytene chromosomes. There is considerable overlap with the sites that are bound by antibodies to z, Pc and the polyhomeotic proteins. This association of the Psc and Su(z)2 proteins with the chromosomes is dependent on the presence of active E(z) protein.
Su(z)2 alleles are dominant suppressors of the yellow eye color associated with the z1 mutation. Can be detected in homozygous z1 females and in males. Lethal in homozygous or hemizygous condition and in trans-allelic heterozygotes. Viability reduced in transheterozygotes in some Psc1/Su(z)2 combinations, lethal in others.