Gef26, dizzy, GEF, l(2)k13720, dPDZ-GEF
Low-frequency RNA-Seq exon junction(s) not annotated.
Annotated transcripts do not represent all supported alternative splices within 5' UTR.
Gene model reviewed during 5.46
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\PDZ-GEF using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signalsView Dmel\PDZ-GEF in GBrowse 2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
FlyBase curator comment: Renamed from 'Gef26' to 'PDZ-GEF' because: i) 'Gef26' isn't very informative; ii) There are no recorded publications that use 'Gef26'; iii) the first paper to characterize the gene (FBrf0152217) called the gene 'PDZ-GEF'; iv) 'PDZ-GEF' is descriptive and popular in the literature.
Source for identity of Gef26 CG9491 was sequence comparison ( date:011113 ).
Gef26 is necessary for the maintenance (formation?) of adherens junctions which anchor male germline stem cells to the hub in the testis.
Plays a role in the development of the spermathecae.
Mutant females show supernumerary spermathecae.
PDZ-GEF is the first component of a conserved "inside-out" signalling pathway which changes the adhesive properties of macrophages via integrins.
dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.