FB2022_03, released June 9, 2022

Gene: Dmel\mir-276a

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General Information
Symbol
Dmel\mir-276a
Species
D. melanogaster
Name
mir-276a stem loop
Annotation Symbol
CR43001
Feature Type
miRNA_gene
FlyBase ID
FBgn0266076
Gene Model Status
Current
Stock Availability
7 publicly available
Gene Summary
Contribute a Gene Snapshot for this gene.
All Summaries
Also Known As

dme-mir-276a, mir-276aS, rosa, miR-276a-3p, miR-276

Key Links
Genomic Location
Cytogenetic map
Sequence location
Recombination map
3-33
RefSeq locus
NT_037436 REGION:10365228..10365325
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (7 terms)
Molecular Function (2 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
enables mRNA 3'-UTR binding
inferred from direct assay
(Zhang et al., 2021)
enables mRNA base-pairing post-transcriptional repressor activity
inferred from direct assay
(Zhang et al., 2021)
Terms Based on Predictions or Assertions (0 terms)
Biological Process (5 terms)
Terms Based on Experimental Evidence (5 terms)
CV Term
Evidence
References
involved_in long-term memory
inferred from mutant phenotype
(Li et al., 2013)
involved_in miRNA-mediated gene silencing
inferred from direct assay
(Zhang et al., 2021)
involved_in olfactory behavior
inferred from mutant phenotype
(Li et al., 2013)
involved_in olfactory learning
inferred from mutant phenotype
(Li et al., 2013)
involved_in regulation of circadian sleep/wake cycle, sleep
inferred from mutant phenotype
(Zhang et al., 2021)
Terms Based on Predictions or Assertions (0 terms)
Cellular Component (0 terms)
There is no information supporting a Cellular Component term for this gene. (Based on a review of available data before: 2006-08-03 )
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (0 terms)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
    -
    Summaries
    Gene Model and Products
    Number of Transcripts
    3
    Number of Unique Polypeptides
    0

    Please see the JBrowse view of Dmel\mir-276a for information on other features

    To submit a correction to a gene model please use the Contact FlyBase form

    Protein Domains (via Pfam)
    Isoform displayed:
    Pfam protein domains
    InterPro name
    classification
    start
    end
    Protein Domains (via SMART)
    Isoform displayed:
    SMART protein domains
    InterPro name
    classification
    start
    end
    Structure New Section
    Comments on Gene Model

    Locations and structures of miRNA models as mapped by miRBase (FBrf0220601).

    Conserved: found throughout the Drosophila genus (FBrf0230987).

    Sequence Ontology: Class of Gene
    gene
    miRNA_gene
    (FlyBase Genome Annotators, 2010, Stark et al., 2003, Stark et al., 2003)
    nuclear_gene
    (FlyBase Genome Annotators, 2010, Stark et al., 2003, Stark et al., 2003)
    Transcript Data
    Annotated Transcripts
    Name
    FlyBase ID
    RefSeq ID
    Length (nt)
    mir-276a-RA
    FBtr0304432
    NR_048254
    23
    mir-276a-RB
    FBtr0304433
    NR_048255
    22
    mir-276a-RM
    FBtr0304431
    NR_048253
    98
    Additional Transcript Data and Comments
    Reported size (kB)
    Comments
    External Data
    Crossreferences
    miRBase - A searchable database of published miRNA sequences and annotation.
    Polypeptide Data
    Annotated Polypeptides
    Polypeptides with Identical Sequences

     

    Additional Polypeptide Data and Comments
    Reported size (kDa)
    Comments
    External Data
    Crossreferences
    Linkouts
    Sequences Consistent with the Gene Model
    Nucleotide / Polypeptide Records
      Mapped Features

      Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\mir-276a using the Feature Mapper tool.

      External Data
      Crossreferences
      Linkouts
      Expression Data
      Expression Summary Ribbons
      Colored tiles in ribbon indicate that the Fly Cell Atlas project found the gene expressed in that cell type. Darker colors mean that more cells of that cell type express the gene:
       low
      high 
      Colorless tiles indicate that there is no scRNAseq data for the gene in that cell type.
      Colored tiles in ribbon indicate that expression data (RNA and/or protein) has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
      Colored tiles in the ribbon indicate the average RNA expression level of the gene at the indicated stages:
       low
      high 
      as determined by RNA-seq (RPKM) using whole organism samples modENCODE, Brown et al., 2014. For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
      Transcript Expression
      Additional Descriptive Data
      Marker for
       
      Subcellular Localization
      CV Term
      Polypeptide Expression
      Additional Descriptive Data
      Marker for
       
      Subcellular Localization
      CV Term
      Evidence
      References
      Expression Deduced from Reporters
      High-Throughput Expression Data
      Associated Tools

      GBrowse - Visual display of RNA-Seq signals

      View Dmel\mir-276a in GBrowse 2
      RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
      Bulk Downloads
      RNA-Seq RPKM values for all genes
      Reference
      See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
      Developmental Proteome: Life Cycle
      Developmental Proteome: Embryogenesis
      External Data and Images
      Linkouts
      DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
      EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
      FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
      Images
      FlyBase Wiki
      Image Based Resources
      Alleles, Insertions, Transgenic Constructs, and Aberrations
      Classical and Insertion Alleles ( 5 )
      For All Classical and Insertion Alleles Show
       
      Other relevant insertions
      Transgenic Constructs ( 12 )
      For All Alleles Carried on Transgenic Constructs Show
      Transgenic constructs containing/affecting coding region of mir-276a
      Transgenic constructs containing regulatory region of mir-276a
      Aberrations (Deficiencies and Duplications) ( 0 )
      Inferred from experimentation ( 0 )
      Inferred from location ( 0 )
      Alleles Representing Disease-Implicated Variants
      Phenotypes
      For more details about a specific phenotype click on the relevant allele symbol.
      Lethality
      Allele
      lethal, with Scer\GAL4Act5C.PU
      lethal, with Scer\GAL4elav.PU
      lethal | recessive
      partially lethal (with Df(3L)ED4457)
      partially lethal | recessive
      viable, with Scer\GAL4Tub.PU
      Other Phenotypes
      Allele
      abnormal chemosensitive behavior, with Scer\GAL4c547
      abnormal chemosensitive behavior, with Scer\GAL4elav.PU
      abnormal chemosensitive behavior (with mir-276aD8)
      abnormal chemosensitive behavior (with mir-276aRosa)
      abnormal chemosensitive behavior | heat sensitive, with Scer\GAL4elav.PU, Scer\GAL80ts.αTub84B
      abnormal locomotor rhythm | adult stage
      abnormal locomotor rhythm | adult stage, with Scer\GAL4P2.4.Pdf
      abnormal locomotor rhythm | adult stage, with Scer\GAL4tim.PE
      abnormal locomotor rhythm | adult stage | RU486 conditional, with Scer\GAL4Pdf.Switch1a
      abnormal memory
      abnormal memory, with Scer\GAL4c747
      abnormal memory, with Scer\GAL4ey-OK107
      abnormal memory | heat sensitive, with Scer\GAL4ey-OK107, Scer\GAL80ts.αTub84B
      short lived | female | recessive
      short lived | male | recessive
      visible, with Scer\GAL4Bx-MS1096
      visible, with Scer\GAL4sd-SG29.1
      Phenotype manifest in
      Allele
      eye, with Scer\GAL4ey.PU
      wing, with Scer\GAL4Bx-MS1096
      wing, with Scer\GAL4sd-SG29.1
      Orthologs
      Downloads
      Download All DIOPT Orthologs
      Human Orthologs (via DIOPT v8.0)
      Homo sapiens (Human) (0)
      No records found.
      Model Organism Orthologs (via DIOPT v8.0)
      Mus musculus (laboratory mouse) (0)
      No records found.
      Rattus norvegicus (Norway rat) (0)
      No records found.
      Xenopus tropicalis (Western clawed frog) (0)
      No records found.
      Danio rerio (Zebrafish) (0)
      No records found.
      Caenorhabditis elegans (Nematode, roundworm) (0)
      No records found.
      Arabidopsis thaliana (thale-cress) (0)
      No records found.
      Saccharomyces cerevisiae (Brewer's yeast) (0)
      No records found.
      Schizosaccharomyces pombe (Fission yeast) (0)
      No records found.
      Other Organism Orthologs (via OrthoDB)
      Paralogs
      Downloads
      Download All DIOPT Paralogs
      Paralogs (via DIOPT v8.0)
      Drosophila melanogaster (Fruit fly) (0)
      No records found.
      Human Disease Associations
      FlyBase Human Disease Model Reports
        Disease Model Summary Ribbon
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Allele
        Disease
        Evidence
        References
        Potential Models Based on Orthology ( 0 )
        Human Ortholog
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Allele
        Disease
        Interaction
        References
        Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
        Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
        Homo sapiens (Human)
        Gene name
        Score
        OMIM
        OMIM Phenotype
        DO term
        Complementation?
        Transgene?
        Functional Complementation Data
        Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
        Interactions
        Summary of Physical Interactions
        Summary of Genetic Interactions
        esyN Network Diagram
        esyN Network Key:
        Suppression
        Enhancement
        View in Interactions Browser
        Please look at the allele data for full details of the genetic interactions
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        mir-276a
        suppressible
        Dop1R1
        (Li et al., 2013)
        mir-276a
        suppressible
        tim
        (Chen and Rosbash, 2016)
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        External Data
        Linkouts
        DroID - A comprehensive database of gene and protein interactions.
        Pathways
        Signaling Pathways (FlyBase)
        Metabolic Pathways
        External Data
        Linkouts
        Genomic Location and Detailed Mapping Data
        Chromosome (arm)
        3L
        Recombination map
        3-33
        Cytogenetic map
        67E2-67E2
        Sequence location
        FlyBase Computed Cytological Location
        Cytogenetic map
        Evidence for location
        67E2-67E2
        Experimentally Determined Cytological Location
        Cytogenetic map
        Notes
        References
        Experimentally Determined Recombination Data
        Location

        3-33

        (FlyBase, 2016)

        3-25.1

        (Comeron et al., 2012)
        Left of (cM)
        Right of (cM)
        Notes
        Stocks and Reagents
        Stocks (7)
        Genomic Clones (24)
        cDNA Clones (0)
         

        Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

        cDNA clones, fully sequenced
        BDGP DGC clones
          Other clones
            Drosophila Genomics Resource Center cDNA clones

            For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

              cDNA Clones, End Sequenced (ESTs)
              BDGP DGC clones
                Other clones
                  RNAi and Array Information
                  Linkouts
                  GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                  Antibody Information
                  Laboratory Generated Antibodies
                   
                  Commercially Available Antibodies
                   
                  Other Information
                  Relationship to Other Genes
                  Source for database identify of
                  Source for database merge of

                  Source for merge of: mir-276a mir-276aS

                  (FlyBase Genome Annotators, 2010)

                  Source for merge of: mir-276a rosa

                  (Li et al., 2013)
                  Additional comments

                  The annotation for mir-276a has been changed in release 5.31 of the genome annotation, so that instead of representing a mature miRNA it now represents the precursor stem loop pre-miRNA. Thus the separate annotations (CR33584 and CR33585) which previously each represented one of the two mature miRNAs made from the mir-276a stem loop precursor have been converted into a single annotation (CR43001).

                  (FlyBase Genome Annotators, 2010)
                  Other Comments

                  mir-276a is required in the mushroom body for conditioned olfactory long-term memory and in R2/R4m subtypes of ellipsoid body neurons for naive olfactory avoidance.

                  (Li et al., 2013)

                  New annotation (CR33585) in release 4.1 of the genome annotation.

                  (FlyBase Genome Annotators, 2005)

                  New annotation (CR33584) in release 4.1 of the genome annotation.

                  (FlyBase Genome Annotators, 2005)
                  Origin and Etymology
                  Discoverer
                  Etymology

                  Given the name "rosa", after one of Pavlov's dogs.

                  (Dubnau et al., 2003)
                  Identification
                  External Crossreferences and Linkouts ( 15 )
                  Sequence Crossreferences
                  NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                  RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                  RNAcentral - A comprehensive ncRNA sequence collection representing all ncRNA types from a broad range of organisms
                  Other crossreferences
                  DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
                  EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
                  FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
                  GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                  KEGG Genes - Molecular building blocks of life in the genomic space.
                  MARRVEL_MODEL - MARRVEL (model organism gene)
                  miRBase - A searchable database of published miRNA sequences and annotation.
                  Linkouts
                  DroID - A comprehensive database of gene and protein interactions.
                  Synonyms and Secondary IDs (20)
                  Reported As
                  Symbol Synonym
                  276a
                  (Han et al., 2011)
                  CR33584
                  (FlyBase Genome Annotators, 2005)
                  CR33585
                  (FlyBase Genome Annotators, 2005)
                  CR43001
                  (FlyBase Genome Annotators, 2010)
                  MIR-276
                  (Ylla et al., 2016)
                  MiR-276a
                  (Yang et al., 2009)
                  dme-miR-276a
                  (Volin et al., 2018, Dhahbi et al., 2016, Towler et al., 2015)
                  dme-miR-276a-3p
                  (Chandra et al., 2015)
                  dme-mir-276
                  (Krishnan et al., 2006)
                  dme-mir-276a
                  (Mohammed et al., 2014, miRBase, 2013, Berezikov et al., 2011, Wang and Liu, 2011, Gesellchen and Boutros, 2004)
                  miR-276
                  (Kadener et al., 2009, Leaman, 2005)
                  miR-276a
                  (Anna and Kannan, 2021, Kitatani et al., 2020, Li et al., 2020, Ma et al., 2020, Rastegari et al., 2020, Xia et al., 2020, Liu et al., 2019, Reichholf et al., 2019, Zhu et al., 2019, Zhu et al., 2019, Xue and Zhang, 2018, Picao-Osorio et al., 2017, Rainey et al., 2016, Cook and Van Vactor, 2015.6.15, Fulga et al., 2015, Suh et al., 2015, Xiong et al., 2015, Abe et al., 2014, Kong et al., 2014, Esslinger et al., 2013, Li et al., 2013, Mezan et al., 2013, Nesler et al., 2013, Smibert et al., 2013, Liu et al., 2012, Liu et al., 2011, Okamura et al., 2011, Büssing et al., 2010, Flynt et al., 2010, Czech et al., 2009, Lee et al., 2009, Ibáñez-Ventoso et al., 2008, Zhao et al., 2008, Behura, 2007, Stark et al., 2005, Rajewsky and Socci, 2004, Rehmsmeier et al., 2004, Lai et al., 2003, Stark et al., 2003, Stark et al., 2003)
                  miR-276a-3p
                  (Lim et al., 2018, Seong et al., 2018)
                  miR-276a-5p
                  (Lim et al., 2018)
                  miR-276aS
                  (Stark et al., 2003, Stark et al., 2003)
                  mir-276
                  (Mishima et al., 2016)
                  mir-276a
                  (Patke et al., 2020, Redmond et al., 2019, Chen and Rosbash, 2016, Mohammed and Lai, 2016.2.8, Chen et al., 2014, Wang et al., 2014, Yeh et al., 2014, Daneshvar et al., 2013, Bejarano et al., 2012, Schertel et al., 2012, Szuplewski et al., 2012, Qian et al., 2011, FlyBase Genome Annotators, 2010, Herranz et al., 2010, Martin et al., 2009, Okamura et al., 2009, Neumuller et al., 2008, Okamura et al., 2008, Liu et al., 2007, Ruby et al., 2007, Burgler and Macdonald, 2005)
                  mir-276aS
                  (Call et al., 2007)
                  rosa
                  (Berger et al., 2008)
                  Name Synonyms
                  miR-276a
                  (Rehmsmeier et al., 2004)
                  mir-276a
                  mir-276a stem loop
                  mir-276aS
                  rosa
                  Secondary FlyBase IDs
                  • FBgn0262439
                  • FBgn0067718
                  • FBgn0067717
                  • FBgn0262294
                  • FBgn0066327
                  Datasets (0)
                  Study focus (0)
                  Experimental Role
                  Project
                  Project Type
                  Title
                  Study result (0)
                  Result
                  Result Type
                  Title
                  References (99)