FlyBase Gene Report: Dmel\Pde8

General Information

Symbol

Dmel\Pde8

Species

D. melanogaster

Name

Phosphodiesterase 8

Annotation Symbol

CG45019

Feature Type

protein_coding_gene

FlyBase ID

FBgn0266377

Gene Model Status

Current

Stock Availability

16 publicly available

Enzyme Name (EC)

3',5'-cyclic-nucleotide phosphodiesterase (3.1.4.17)

3',5'-cyclic-GMP phosphodiesterase (3.1.4.35)

3',5'-cyclic-AMP phosphodiesterase (3.1.4.53)

Gene Summary

Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes (By similarity). Involved in the positive regulation of MAP kinase signaling and in inhibiting oxidative stress-induced cell death (PubMed:23509299). (UniProt, Q6NNF2)

Contribute a Gene Snapshot for this gene.

All Summaries

Alliance
Auto summary
Gene Group
UniProtKB
Interactive Fly

Key Links

Genomic Location

Cytogenetic map

59F5-59F6

Sequence location

2R:23,657,567..23,680,844 [+]

Recombination map

2-104

RefSeq locus

NT_033778 REGION:23657567..23680844

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (9 terms)

Molecular Function (4 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (4 terms)

CV Term

Evidence

References

enables 3',5'-cyclic-AMP phosphodiesterase activity

inferred from sequence model

(Day, 2005)

inferred from biological aspect of ancestor with PANTHER:PTN001682918

(GO Reference Genome Project, 2011-)

enables 3',5'-cyclic-GMP phosphodiesterase activity

inferred from biological aspect of ancestor with PANTHER:PTN001682918

(GO Reference Genome Project, 2011-)

enables 3',5'-cyclic-nucleotide phosphodiesterase activity

inferred from electronic annotation with InterPro:IPR002073, InterPro:IPR036971

(InterPro Project Members, 2004-)

enables phosphoric diester hydrolase activity

inferred from electronic annotation with InterPro:IPR023088

(InterPro Project Members, 2004-)

Biological Process (5 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

involved_in mesoderm development

inferred from expression pattern

(Furlong et al., 2001)

involved_in positive regulation of ERK1 and ERK2 cascade

inferred from mutant phenotype

(Brown et al., 2013)

Terms Based on Predictions or Assertions (4 terms)

CV Term

Evidence

References

involved_in cAMP metabolic process

inferred from sequence model

(Day, 2005)

involved_in cAMP-mediated signaling

inferred from biological aspect of ancestor with PANTHER:PTN001682918

(GO Reference Genome Project, 2011-)

involved_in positive regulation of ERK1 and ERK2 cascade

inferred from biological aspect of ancestor with PANTHER:PTN000886896

(GO Reference Genome Project, 2011-)

involved_in signal transduction

inferred from electronic annotation with InterPro:IPR002073, InterPro:IPR036971

(InterPro Project Members, 2004-)

Cellular Component (0 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (0 terms)

Gene Group (FlyBase)

CYCLIC-NUCLEOTIDE PHOSPHODIESTERASES

Protein Family (UniProt)

Belongs to the cyclic nucleotide phosphodiesterase family. PDE8 subfamily. (Q6NNF2)

Protein Signatures (InterPro)

Catalytic Activity (EC/Rhea)

3',5'-cyclic-AMP phosphodiesterase activity

3',5'-cyclic AMP + H2O = AMP + H(+) (3.1.4.53)

RHEA 25277: 3',5'-cyclic-nucleotide phosphodiesterase activity

a nucleoside 3',5'-cyclic phosphate + H2O = a nucleoside 5'-phosphate + H(+) (3.1.4.17)

RHEA 14653: 3',5'-cyclic-GMP phosphodiesterase activity

3',5'-cyclic GMP + H2O = GMP + H(+) (3.1.4.35)

RHEA 16957:

Summaries

Gene Group (FlyBase)

CYCLIC-NUCLEOTIDE PHOSPHODIESTERASES -: Cyclic-nucleotide phosphodiesterases are hydrolases that catalyze the hydrolysis of a nucleoside cyclic phosphate into a nucleoside phosphate.

Protein Function (UniProtKB)

(UniProt, Q6NNF2)

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Pde8 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q6NNF2)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.48

Annotated transcripts do not represent all supported alternative splices within 5' UTR.

Gene model reviewed during 6.33

Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.44

Stop-codon suppression (UAG) postulated; FBrf0216884

Gene model reviewed during 5.53

A subset of the transcripts annotated for this gene are postulated to be circular mRNAs (FBrf0236596).

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Pde8-RA

FBtr0344180

NM_166616

3939

914

Pde8-RB

FBtr0344179

NM_166618

4331

904

Pde8-RC

FBtr0344176

NM_166619

2855

400

Pde8-RD

FBtr0344177

NM_166617

3982

805

Pde8-RE

FBtr0344178

NM_137970

5393

905

Pde8-RI

FBtr0344182

NM_001169803

5562

914

Pde8-RK

FBtr0344183

NM_001169805

5389

914

Pde8-RN

FBtr0344181

NM_001169807

3939

949

Pde8-RO

FBtr0344184

NM_001169804

4895

1050

Pde8-RP

FBtr0480522

NM_001414110

1234

119

Pde8-RQ

FBtr0480523

NM_001414111

687

122

Pde8-RR

FBtr0480524

NM_001414112

819

215

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

Pde8-PA

FBpp0310592

102.1

914

6.83

FBpp0310591

100.3

904

6.48

FBpp0310588

45.7

400

5.30

FBpp0310589

90.7

805

6.63

FBpp0310590

101.0

905

6.83

FBpp0310594

102.1

914

6.83

FBpp0310595

102.1

914

6.83

FBpp0310593

105.8

949

6.81

FBpp0310596

117.7

1050

6.61

FBpp0428313

12.5

119

9.11

C0PDF0

ACZ94543

Pde8-PQ

FBpp0428314

12.9

122

9.11

UYI57914

Pde8-PR

FBpp0428315

23.0

215

9.79

UYI57915

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

914 aa isoforms: Pde8-PA, Pde8-PI, Pde8-PK

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Pde8 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-1.43

Transcript Expression

expression microarray

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage | male

(Arbeitman et al., 2004)

adult stage

adult fat body

Comment: cyclical, peak ZT21-0

(Xu et al., 2011)

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 11 -- 12

salivary gland body primordium

(Fisher et al., 2012)

embryonic stage 13 -- 16

embryonic/larval midgut

(Fisher et al., 2012)

embryonic Malpighian tubule

(Fisher et al., 2012)

embryonic hindgut

(Fisher et al., 2012)

embryonic anal pad

(Fisher et al., 2012)

Additional Descriptive Data

Expressed cyclically in the adult fat body.

(Xu et al., 2011)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Pde8 in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Pde8

View exonic expression by tissue for Dmel\Pde8

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0266377

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

37741/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0266377

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0034886

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0266377

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG5411

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 23 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 6 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Pde8

Transgenic constructs containing regulatory region of Pde8

Aberrations (Deficiencies and Duplications) ( 1 )

Inferred from experimentation ( 1 )

Gene disrupted in

Df(2R)Exel7180

(Ryder, 2004.4.26)

Inferred from location ( 7 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

viable

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Pde8^GD10547

viable, with Scer\GAL4^pnr-MD237

Pde8^GD10547

viable, with Scer\GAL4^tin.CΔ4

Pde8^GD10547

Sterility

Allele

fertile

Other Phenotypes

Allele

abnormal circadian rhythm, with Scer\GAL4^P0.5.Pdf

Pde8^EY10946

abnormal flight, with Scer\GAL4^Mef2.PR

Pde8^GD10547

abnormal neuroanatomy, with Scer\GAL4^elav-C155

Pde8^EY10143

abnormal oxidative stress response

Pde8^del

abnormal pain response | adult stage, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Pde8^GD10547

chemical sensitive

Pde8^del

Phenotype manifest in

Allele

synapse, with Scer\GAL4^elav-C155

Pde8^EY10143

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (21)

Hsap\PDE8B

13 of 14

Yes

Hsap\PDE8A

12 of 14

Yes

4 of 14

4 of 14

4 of 14

3 of 14

3 of 14

Yes

Hsap\PDE3B

3 of 14

Yes

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (21)

Rnor\Pde8b

13 of 14

Yes

Rnor\Pde8a

12 of 14

Yes

4 of 14

4 of 14

4 of 14

3 of 14

3 of 14

3 of 14

Yes

Rnor\Pde3b

3 of 14

Yes

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

Yes

3 of 14

2 of 14

2 of 14

2 of 14

2 of 14

Mus musculus (laboratory mouse) (21)

Mmus\Pde8b

13 of 14

Yes

Mmus\Pde8a

12 of 14

Yes

4 of 14

4 of 14

4 of 14

3 of 14

3 of 14

3 of 14

Yes

Mmus\Pde3b

3 of 14

Yes

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

Xenopus tropicalis (Western clawed frog) (33)

Xtro\pde8b

8 of 13

Yes

Xtro\pde8a

7 of 13

Yes

Xtro\dleu7

5 of 13

Yes

3 of 13

3 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

Yes

2 of 13

2 of 13

1 of 13

1 of 13

Yes

Xtro\cdc27

1 of 13

Xtro\golga5

1 of 13

Xtro\LOC100486753

1 of 13

Yes

Xtro\LOC101734687

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\pde3b

1 of 13

Yes

Xtro\pde6c

1 of 13

Xtro\pde7a

1 of 13

Yes

Xtro\pde10a

1 of 13

Xtro\pde11a

1 of 13

Xtro\yipf6

1 of 13

Danio rerio (Zebrafish) (27)

Drer\pde8b

13 of 14

Yes

Drer\pde8a

11 of 14

Yes

4 of 14

4 of 14

4 of 14

4 of 14

3 of 14

3 of 14

Yes

Drer\pde3b

3 of 14

Yes

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

Yes

3 of 14

3 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

Drer\si:dkey-219c10.4

2 of 14

Drer\pde1ca

1 of 14

Yes

Drer\pde2a

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (6)

Cele\pde-6

9 of 14

Yes

3 of 14

2 of 14

2 of 14

2 of 14

2 of 14

Anopheles gambiae (African malaria mosquito) (8)

Agam\AgaP_AGAP007163

11 of 12

Yes

3 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

Arabidopsis thaliana (thale-cress) (0)

Saccharomyces cerevisiae (Brewer's yeast) (1)

Scer\PDE2

5 of 13

Yes

Schizosaccharomyces pombe (Fission yeast) (0)

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:Pde8. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (5)

7 of 13

6 of 13

6 of 13

5 of 13

5 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 3 )

Human Ortholog

Disease

Evidence

References

PDE8B; phosphodiesterase 8B

model of striatonigral degeneration

IEA

(FlyBase, 2019-)

model of primary pigmented nodular adrenocortical disease 3

IEA

(FlyBase, 2019-)

PDE3A; phosphodiesterase 3A

model of hypertension and brachydactyly syndrome

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

PDE8B; phosphodiesterase 8B

13 of 14

603390

PDE8A; phosphodiesterase 8A

12 of 14

602972

PDE4A; phosphodiesterase 4A

4 of 14

600126

PDE4C; phosphodiesterase 4C

4 of 14

600128

PDE4D; phosphodiesterase 4D

4 of 14

600129

ACRODYSOSTOSIS 2 WITH OR WITHOUT HORMONE RESISTANCE; ACRDYS2

acrodysostosis

PDE1C; phosphodiesterase 1C

3 of 14

602987

DEAFNESS, AUTOSOMAL DOMINANT 74; DFNA74

autosomal dominant nonsyndromic deafness 74

PDE3A; phosphodiesterase 3A

3 of 14

123805

HYPERTENSION AND BRACHYDACTYLY SYNDROME; HTNB

hypertension and brachydactyly syndrome

PDE3B; phosphodiesterase 3B

3 of 14

602047

PDE4B; phosphodiesterase 4B

3 of 14

600127

PDE5A; phosphodiesterase 5A

3 of 14

603310

PDE6A; phosphodiesterase 6A

3 of 14

180071

RETINITIS PIGMENTOSA 43; RP43

retinitis pigmentosa 43

PDE6B; phosphodiesterase 6B

3 of 14

180072

PDE6C; phosphodiesterase 6C

3 of 14

600827

CONE DYSTROPHY 4; COD4

PDE7A; phosphodiesterase 7A

3 of 14

171885

PDE7B; phosphodiesterase 7B

3 of 14

604645

PDE11A; phosphodiesterase 11A

3 of 14

604961

PIGMENTED NODULAR ADRENOCORTICAL DISEASE, PRIMARY, 2; PPNAD2

primary pigmented nodular adrenocortical disease 2

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

Pde8 - βTub85D

experimental knowledge based

(Guruharsha et al., 2011)

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Jra|kay

suppressible

Pde8

(Franciscovich et al., 2008)

kay

enhanceable

Pde8

(Franciscovich et al., 2008)

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0266377

MIST (protein-protein) - An integrated Molecular Interaction Database

37741

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

KEGG Metabolic Pathways - A collection of manually drawn metabolic pathway maps representing knowledge of molecular interaction, reaction and relation networks.

External Data

Linkouts

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

G alpha (s) signalling events

Class of Gene

gene_with_stop_codon_read_through

(Jungreis et al., 2011)

nuclear_gene

(FlyBase Genome Annotators, 2008)

protein_coding_gene

(FlyBase Genome Annotators, 2008)

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-104

Cytogenetic map

59F5-59F6

Sequence location

2R:23,657,567..23,680,844 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

59F5-59F6

Limits computationally determined from genome sequence between P{PZ}apt⁰³⁰⁴¹ and P{EP}egl^EP938

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

2-104

(FlyBase, 2016)

2-108.8

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (16)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

51892

y¹ v¹; P{TRiP.HMC03466}attP40

65635

w¹¹¹⁸; PBac{IT.GAL4}Pde8^1246-G4

44749

y¹ w^*; Mi{MIC}Pde8^MI08109

53157

y¹ w^*; Mi{MIC}Pde8^MI09719

53442

y¹ w^*; Mi{MIC}Pde8^MI10026

50814

y¹ w^*; P{PTT-GA}Pde8^CA07101

9775

y¹ w^*; P{UASp-YFP.Rab5}Pde8^08b

17642

y¹ w^67c23; P{EPgy2}Pde8^EY10143

20233

y¹ w^67c23; P{EPgy2}Pde8^EY10946

42080

y¹ w^*; Mi{MIC}Pde8^MI05352/SM6a

VDRC

v101413

P{KK109095}VIE-260B

v25976

w¹¹¹⁸; P{GD10547}v25976

More stocks available...

Genomic Clones (11)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (156)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0266377

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

New annotation (CG42241) in release 5.7 of the genome annotation.

(FlyBase Genome Annotators, 2008)

Relationship to Other Genes

Source for database merge of

Source for merge of: Pde8 CG42241

(FlyBase Genome Annotators, 2013)

Additional comments

Annotations CG5411 and CG42241 merged as CG45019 in release 5.53 of the genome annotation. Merge supported by RNA-seq junction data.

(FlyBase Genome Annotators, 2013)

Nomenclature History

Source for database identify of

Source for identity of: Pde8 CG5411

(Day and Davies, 2003.6.10)

Nomenclature comments

Etymology

Synonyms and Secondary IDs (7)

Reported As

Symbol Synonym

CG42241

(FlyBase Genome Annotators, 2008)

CG45019

(National Institute of Genetics Fly Stocks, 2022-, FlyBase Genome Annotators, 2013)

CG5411

(Aerts et al., 2010, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Mack et al., 2006, Day, 2005, Kim et al., 2005, Arbeitman et al., 2004, Berger et al., 2001, Furlong et al., 2001)

PDE8

(Davies et al., 2014, Brown et al., 2013, Clemens-Grisham et al., 2008, Day, 2005, Day and Davies, 2003.6.10)

Pde8

(Menzies et al., 2024, Aboukilila et al., 2020, Yildirim et al., 2019, Pamudurti et al., 2017, Transgenic RNAi Project members, 2017-, Clandinin and Owens, 2016-, Li et al., 2015, Ashwal-Fluss et al., 2014, Belozerov et al., 2014, Jungreis et al., 2011, Xu et al., 2011, Aerts et al., 2010, Dahdal et al., 2010, Kadener et al., 2009, Franciscovich et al., 2008, Buszczak et al., 2007, Firth and Baker, 2007, Zhang et al., 2007, Kim et al., 2005)

pde8

(Franciscovich et al., 2008)

Name Synonyms

Phosphodiesterase 8

(Day and Davies, 2003.6.10)

Secondary FlyBase IDs

FBgn0034886
FBgn0250870

Datasets (0)

Study focus (0)

Experimental Role

Project

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Title

Study result (0)

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External Crossreferences and Linkouts ( 105 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

37741

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q6NNF2

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

Q6NNF2

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q6NNF2

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0266377

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

37741/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0266377

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0266377

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG45019

MARRVEL_MODEL - MARRVEL (model organism gene)

37741

Linkouts

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0266377

DroID - A comprehensive database of gene and protein interactions.

FBgn0266377

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0034886

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0266377

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG5411

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0266377

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC033870

KEGG Metabolic Pathways - A collection of manually drawn metabolic pathway maps representing knowledge of molecular interaction, reaction and relation networks.

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

MIST (protein-protein) - An integrated Molecular Interaction Database

37741

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

G alpha (s) signalling events

References (65)

The following external sites may use different assemblies or annotations than FlyBase.

-1.43

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