FB2019_05, released Oct 15, 2019

Gene: Dmel\Ote

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General Information
Symbol
Dmel\Ote
Species
D. melanogaster
Name
Otefin
Annotation Symbol
CG5581
Feature Type
protein_coding_gene
FlyBase ID
FBgn0266420
Gene Model Status
Current
Stock Availability
7 publicly available
Gene Snapshot
Otefin (Ote) encodes a nuclear membrane-associated protein that acts in concert with BMP/Dpp signaling to mediate bam transcriptional silencing. Its roles include oogenesis and germline stem cell self-renewal and differentiation. [Date last reviewed: 2019-03-14]
Other Summaries
Also Known As
hal
Key Links
Genomic Location
Cytogenetic map
55A1-55A1
Sequence location
2R:18,275,607..18,277,177 [-]
Recombination map
2-85
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Pathway (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Molecular Function (GO)
[Detailed GO annotations]
Experimental Evidence
protein binding; transcription corepressor activity; transcription factor binding
Predictions / Assertions
-
Summaries
Pathway (FlyBase)
Positive Regulators of BMP Signaling Pathway -
Positive regulators of Bone Morphogenetic Protein (BMP) signaling up-regulate the pathway, ultimately resulting in the increased nuclear activity of the Mad/Med transcription factor complex.
Protein Function (UniProtKB)
Inner nuclear membrane protein (PubMed:2186029, PubMed:9199347, PubMed:18410727, PubMed:22751930). Involved in the attachment of membrane vesicles to chromatin during nuclear assembly, and is probably required for centrosome maturation and cell cycle progression during mitosis (PubMed:9199347, PubMed:22751930). Essential for differentiation of certain tissues and the maintenance of progenitor cell populations (PubMed:18410727, PubMed:24700158, PubMed:23806619, PubMed:27174470). Required for the differentiation and maintenance of male and female germline stem cells (GSCs), as well as the maintenance of somatic cells in the GSC niche (PubMed:18410727, PubMed:23806619, PubMed:27174470). This role is likely to be independent of the BMP (Dpp) pathway that negatively regulates bam transcription during GSC differentiation (PubMed:18410727, PubMed:23806619). During development, plays essential and redundant functions with the other LEM domain proteins; bocks and MAN1 (PubMed:24700158). Also has a redundant but important role with bocks during larval development (PubMed:24700158).
(UniProt, P20240)
Summary (Interactive Fly)
a nuclear lamin that is essential for germline stem cell maintenance - physically interacts with Medea/Smad4 at the silencer element to regulate GSC fate
Gene Model and Products
Number of Transcripts
1
Number of Unique Polypeptides
1

Please see the GBrowse view of Dmel\Ote or the JBrowse view of Dmel\Ote for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model
Gene model reviewed during 5.50
Gene model reviewed during 5.44
Gene model reviewed during 5.39
Sequence Ontology: Class of Gene
gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Ote-RA
FBtr0086768
NM_057316
1571
424
Additional Transcript Data and Comments
Reported size (kB)
1.6 (northern blot)
(Padan et al., 1990)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
Ote-PA
FBpp0085947
46.6
424
9.99
NP_476664
AAF57722
Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments
Reported size (kDa)
406 (aa); 45 (kD predicted)
(Padan et al., 1990)
53 (kD observed)
(Harel et al., 1989)
Comments
External Data
Subunit Structure (UniProtKB)
Interacts with Med (PubMed:18410727). Interacts with Lam (PubMed:9632815, PubMed:22751930). Interacts with aurA, alphaTub84B, gammaTub23C and gammaTub37C (PubMed:22751930).
(UniProt, P20240)
Post Translational Modification
Phosphorylation at Thr-63 by aurA may be required for exit from mitosis (PubMed:22751930). May be phosphorylated by Cdk1 and Pka-C1 (PubMed:9199347).
(UniProt, P20240)
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Nucleotide / Polypeptide Records
 
UniProt
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Ote using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Gene Ontology (14 terms)
Molecular Function (3 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
protein binding
inferred from physical interaction with FLYBASE:Lam; FB:FBgn0002525
(Goldberg et al., 1998)
transcription corepressor activity
inferred from mutant phenotype
(Jiang et al., 2008)
transcription factor binding
inferred from physical interaction with FLYBASE:Med; FB:FBgn0011655
(Jiang et al., 2008)
Terms Based on Predictions or Assertions (0 terms)
Biological Process (6 terms)
Terms Based on Experimental Evidence (6 terms)
CV Term
Evidence
References
germ-line stem cell population maintenance
inferred from mutant phenotype
(Jiang et al., 2008)
germ-line stem-cell niche homeostasis
inferred from mutant phenotype
(Barton et al., 2016)
negative regulation of transcription, DNA-templated
inferred from mutant phenotype
(Jiang et al., 2008)
nuclear envelope reassembly
inferred from direct assay
(Ashery-Padan et al., 1997)
oogenesis
inferred from high throughput mutant phenotype
(Schupbach and Wieschaus, 1991)
positive regulation of BMP signaling pathway
inferred from genetic interaction with FLYBASE:tkv; FB:FBgn0003716
(Jiang et al., 2008)
Terms Based on Predictions or Assertions (0 terms)
Cellular Component (5 terms)
Terms Based on Experimental Evidence (5 terms)
CV Term
Evidence
References
endomembrane system
inferred from high throughput direct assay
(Tan et al., 2009)
nuclear envelope lumen
inferred from direct assay
(assigned by UniProt )
(Harel et al., 1989)
nuclear inner membrane
inferred from direct assay
(Ashery-Padan et al., 1997)
nuclear membrane
inferred from direct assay
(Jiang et al., 2008)
nuclear periphery
inferred from direct assay
(Dialynas et al., 2010)
Terms Based on Predictions or Assertions (0 terms)
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage & pupal stage
(Harel et al., 1989)
embryonic stage -- adult stage
(Ashery-Padan et al., 1997)
embryonic stage 12 -- 13
organism
(Harel et al., 1989)
oogenesis
(Ashery-Padan et al., 1997)
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
Additional Descriptive Data
Using EM immunogold labeling, Ote protein was localized to the nucleoplasmic side of the inner nuclear membrane.
(Ashery-Padan et al., 1997)
Between stages S4 and S6-S7 of oogenesis, Ote protein localizes to the nuclear envelope of nurse cells, follicle cells and oocytes, but after stage S6-S7, nucleoplasmic and cytoplasmic accumulation is also observed. During embryogenesis, Ote protein is associated with the nucleus as well as with nonnuclear membrane vesicles. Like Lam protein, Ote protein is detected in the nuclei of most cells during larval, pupal and adult stages. Neither protein is detected in stages 6-11 of spermiogenesis. In larval and adult tissues, Ote pr tein localizes to the nuclear envelope.
(Ashery-Padan et al., 1997)
Ote protein is detected at high levels in embryos and during pupation. In embryos and tissue culture cells, Ote protein localizes to the periphery of the nucleus.
(Harel et al., 1989)
Marker for
 
Subcellular Localization
CV Term
Evidence
References
endomembrane system
inferred from high throughput direct assay
(Tan et al., 2009)
nuclear envelope lumen
inferred from direct assay
(assigned by UniProt )
(Harel et al., 1989)
nuclear inner membrane
inferred from direct assay
(Ashery-Padan et al., 1997)
nuclear membrane
inferred from direct assay
(Jiang et al., 2008)
nuclear periphery
inferred from direct assay
(Dialynas et al., 2010)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Ote in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 6 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 18 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Ote
Transgenic constructs containing regulatory region of Ote
Deletions and Duplications ( 4 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4pnr-MD237
viable (with OteB279)
viable (with OtePK)
Sterility
Allele
female sterile
Other Phenotypes
Allele
cell adhesion defective | adult stage (with OteB279)
cell adhesion defective | adult stage (with OtePK)
decreased cell number | adult stage | conditional, with Scer\GAL4VP16.nos.UTR
decreased cell number | adult stage | progressive (with OteB279)
decreased cell number | adult stage | progressive (with OtePK)
decreased fecundity | female (with OteB279)
decreased fecundity | female (with OtePK)
decreased fecundity | male | progressive (with OteB279)
decreased fecundity | male | progressive (with OtePK)
developmental rate defective | female | larval stage (with OteB279)
developmental rate defective | female | larval stage (with OtePK)
size defective | third instar larval stage (with OteB279)
size defective | third instar larval stage (with OtePK)
Phenotype manifest in
Allele
abdominal 1 lateral transverse muscle, with Scer\GAL4Mef2.PU
egg
escort cell | adult stage (with OteB279)
escort cell | adult stage (with OtePK)
female germline cell (with OteB279)
female germline cell (with OtePK)
female germline cell | adult stage (with OteB279)
female germline cell | adult stage (with OtePK)
female germline cell | larval stage
female germline stem cell
female germline stem cell, with Scer\GAL4VP16.nos.UTR
female germline stem cell | adult stage (with OteB279)
female germline stem cell | adult stage (with OtePK)
female germline stem cell | germline clone
female germline stem cell | supernumerary
fusome
fusome (with Df(2R)ED3636)
fusome (with OteB279)
fusome (with OteEMS)
fusome (with OtePK)
germarium
germarium, with Scer\GAL4VP16.nos.UTR
germarium (with Df(2R)ED3636)
germarium (with OteB279)
germarium (with OteEMS)
germarium (with OtePK)
germarium cap cell | adult stage | progressive (with OteB279)
germarium cap cell | adult stage | progressive (with OtePK)
germinal proliferation center hub | adult stage | progressive (with OteB279)
germinal proliferation center hub | adult stage | progressive (with OtePK)
hub cell | adult stage (with OteB279)
hub cell | adult stage (with OtePK)
male germline cell | adult stage (with OteB279)
male germline cell | adult stage (with OtePK)
male germline cell | third instar larval stage (with OteB279)
male germline cell | third instar larval stage (with OtePK)
male germline stem cell | adult stage (with OteB279)
male germline stem cell | adult stage (with OtePK)
nucleus, with Scer\GAL4Mef2.PU
nucleus, with Scer\GAL4twi.PU
ovary
ovary, with Scer\GAL4VP16.nos.UTR
spectrosome
spectrosome (with Df(2R)ED3636)
spectrosome (with OteB279)
spectrosome (with OteEMS)
spectrosome (with OtePK)
terminal filament | larval stage (with OteB279)
terminal filament | larval stage (with OtePK)
testis | third instar larval stage (with OteB279)
testis | third instar larval stage (with OtePK)
ventral longitudinal muscle 3 | larval stage, with Scer\GAL4Mef2.PU
ventral longitudinal muscle 3 | larval stage, with Scer\GAL4twi.PU
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v7.1)
Homo sapiens (Human) (0)
No records found.
Model Organism Orthologs (via DIOPT v7.1)
Mus musculus (laboratory mouse) (0)
No records found.
Rattus norvegicus (Norway rat) (0)
No records found.
Xenopus tropicalis (Western clawed frog) (0)
No records found.
Danio rerio (Zebrafish) (0)
No records found.
Caenorhabditis elegans (Nematode, roundworm) (0)
No records found.
Arabidopsis thaliana (thale-cress) (0)
No records found.
Saccharomyces cerevisiae (Brewer's yeast) (0)
No records found.
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG09190BFK )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila melanogaster
fruit fly
Dmel\Ote
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00005746
Drosophila simulans
Dsim\GD25400
Drosophila sechellia
Dsec\GM19914
Drosophila erecta
Dere\GG20980
Drosophila yakuba
Dyak\GE13920
Drosophila ananassae
Dana\GF12772
Drosophila pseudoobscura pseudoobscura
Dpse\GA18984
Drosophila persimilis
Dper\GL16712
Drosophila persimilis
Dper\GL16713
Drosophila willistoni
Dwil\GK23240
Drosophila willistoni
Dwil\GK10185
Drosophila virilis
Dvir\GJ22457
Drosophila mojavensis
Dmoj\GI19394
Drosophila grimshawi
Dgri\GH20225
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( None identified )
No non-Drosophilid orthologies identified
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( None identified )
No non-Dipteran orthologies identified
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( None identified )
No non-Insect Arthropod orthologies identified
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( None identified )
No non-Arthropod Metazoa orthologies identified
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v7.1)
Drosophila melanogaster (Fruit fly) (1)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
bocks
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
     
    Disease Associations of Human Orthologs (via DIOPT v7.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    Functional Complementation Data
    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
    Interactions
    Summary of Physical Interactions
    esyN Network Diagram
    Show neighbor-neighbor interactions:
    Select Layout:
    Legend:
    Protein
    RNA
    Selected Interactor(s)
    Interactions Browser
    View in Interactions Browser
    Please see the Physical Interaction reports below for full details
    protein-protein
    Physical Interaction
    Assay
    References
    Ote - Brca2
    ion exchange chromatography, peptide massfingerprinting
    (Kusch, 2015)
    Ote - CG10214
    experimental knowledge based
    (Guruharsha et al., 2011)
    Ote - CG2199
    experimental knowledge based
    (Guruharsha et al., 2011)
    Ote - CG4407
    experimental knowledge based
    (Guruharsha et al., 2011)
    Ote - Gnf1
    experimental knowledge based
    (Guruharsha et al., 2011)
    Ote - Hmgs
    experimental knowledge based
    (Guruharsha et al., 2011)
    Ote - Lam
    two hybrid, anti tag coimmunoprecipitation, western blot, experimental knowledge based, anti bait coimmunoprecipitation
    (Habermann et al., 2012, Guruharsha et al., 2011, Goldberg et al., 1998)
    Ote - Med
    anti bait coimmunoprecipitation, anti tag western blot, anti tag coimmunoprecipitation, western blot, fluorescent resonance energy transfer, fluorescence microscopy
    (Jiang et al., 2008)
    Ote - Mer
    anti tag coimmunoprecipitation, peptide massfingerprinting
    (Kwon et al., 2013)
    Ote - PSR
    experimental knowledge based
    (Guruharsha et al., 2011)
    Ote - aurA
    anti tag coimmunoprecipitation, western blot
    (Habermann et al., 2012)
    Ote - baf
    two hybrid
    (Pinto et al., 2008)
    Ote - bocks
    experimental knowledge based
    (Guruharsha et al., 2011)
    Ote - cnn
    anti bait coimmunoprecipitation, peptide massfingerprinting
    (Habermann et al., 2012)
    Ote - smt3
    anti tag coimmunoprecipitation, comigration in sds page, anti tag western blot
    (Pirone et al., 2017)
    Ote - γTub23C
    anti tag coimmunoprecipitation, western blot
    (Habermann et al., 2012)
    Ote - γTub37C
    anti tag coimmunoprecipitation, western blot
    (Habermann et al., 2012)
    Summary of Genetic Interactions
    esyN Network Diagram
    esyN Network Key:
    Suppression
    Enhancement
    View in Interactions Browser
    Please look at the allele data for full details of the genetic interactions
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    Ote
    suppressible
    bocks
    (Barton et al., 2014)
    Ote
    enhanceable
    bocks
    (Barton et al., 2014)
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    tkv
    suppressible
    Ote
    (Jiang et al., 2008)
    External Data
    Subunit Structure (UniProtKB)
    Interacts with Med (PubMed:18410727). Interacts with Lam (PubMed:9632815, PubMed:22751930). Interacts with aurA, alphaTub84B, gammaTub23C and gammaTub37C (PubMed:22751930).
    (UniProt, P20240 )
    Linkouts
    DroID - A comprehensive database of gene and protein interactions.
    MIST (genetic) - An integrated Molecular Interaction Database
    MIST (protein-protein) - An integrated Molecular Interaction Database
    Pathways
    Gene Group - Pathway Membership (FlyBase)
    Positive Regulators of BMP Signaling Pathway -
    Positive regulators of Bone Morphogenetic Protein (BMP) signaling up-regulate the pathway, ultimately resulting in the increased nuclear activity of the Mad/Med transcription factor complex.
    External Data
    Linkouts
    Genomic Location and Detailed Mapping Data
    Chromosome (arm)
    2R
    Recombination map
    2-85
    Cytogenetic map
    55A1-55A1
    Sequence location
    2R:18,275,607..18,277,177 [-]
    FlyBase Computed Cytological Location
    Cytogenetic map
    Evidence for location
    55A1-55A1
    Left limit from inclusion within Df(2R)PC4 (FBrf0054123) Right limit from non-inclusion within Df(2R)Pcl11B (FBrf0086812)
    Experimentally Determined Cytological Location
    Cytogenetic map
    Notes
    References
    55C-55C
    (determined by in situ hybridisation)
    (Padan et al., 1990)
    Experimentally Determined Recombination Data
    Location
    2-85
    (FlyBase, 2016)
    2-89.3
    (Comeron et al., 2012)
    2-[86]
    Left of (cM)
    Right of (cM)
    Notes
    Stocks and Reagents
    Stocks (7)
    Genomic Clones (17)
     

    Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

    cDNA Clones (178)
     

    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

    cDNA clones, fully sequences
    BDGP DGC clones
    Other clones
      Drosophila Genomics Resource Center cDNA clones

      For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

      cDNA Clones, End Sequenced (ESTs)
      BDGP DGC clones
      Other clones
      RNAi and Array Information
      Linkouts
      GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
      Antibody Information
      Laboratory Generated Antibodies
       
      polyclonal
      (Barton et al., 2014, Jiang et al., 2008, Wagner et al., 2004, Padan et al., 1990)
      monoclonal
      (Harel et al., 1989)
      Commercially Available Antibodies
       
      Other Information
      Relationship to Other Genes
      Source for database identify of
      Source for database merge of
      Source for merge of: Ote hal
      (Barton et al., 2013)
      Additional comments
      Other Comments
      Ote is required autonomously for the survival of germline stem cells and non-autonomously for the maintenance of their somatic niche in both males and females.
      (Barton et al., 2016)
      The absence of Ote function does not cause female germ cell loss through activation of bam transcription. The primary defect in mutant female germline stem cells is a block of differentiation, which ultimately leads to germ cell death.
      (Barton et al., 2013)
      Lam protein interacts with both Ote and fs(1)Ya in a yeast two-hybrid system.
      (Goldberg et al., 1998)
      Ote behaves as a peripheral protein and is localised to the nucleoplasmic side of the nuclear envelope. Expression studies reveal the C-terminal 11 amino acid hydrophobic sequence is essential for targeting Ote to the nuclear periphery.
      (Ashery-Padan et al., 1997)
      Characterisation of Ote suggests an essential role in the assembly of the nuclear envelope.
      (Ashery-Padan et al., 1997)
      The hal locus affects early oogenesis: mutations cause the production of few, defective germ cells.
      (Schupbach and Wieschaus, 1991)
      Ote has been cloned and sequenced.
      (Padan et al., 1990)
      Ote protein is not a component of nuclear pore complexes. Some Ote protein is apparently retained in an envelope-like structure throughout mitosis in early Drosophila embryos.
      (Harel et al., 1989)
      Origin and Etymology
      Discoverer
      Etymology
      The name 'otefin' is a transliteration of the Hebrew word meaning 'envelopes'.
      (Harel et al., 1989)
      Identification
      External Crossreferences and Linkouts ( 25 )
      Sequence Crossreferences
      NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
      GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
      GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
      RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
      UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
      Other crossreferences
      BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
      Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
      Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
      Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
      GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
      InterPro - A database of protein families, domains and functional sites
      KEGG Genes - Molecular building blocks of life in the genomic space.
      Linkouts
      DroID - A comprehensive database of gene and protein interactions.
      Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
      MIST (genetic) - An integrated Molecular Interaction Database
      MIST (protein-protein) - An integrated Molecular Interaction Database
      Synonyms and Secondary IDs (8)
      Reported As
      Symbol Synonym
      CG5581
      (Kolkhof et al., 2017, Çiçek et al., 2016, Müller et al., 2010, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Perkins et al., 2009, Haussmann et al., 2008)
      Ote
      (Bhide et al., 2018, Petrovsky and Großhans, 2018, Collins et al., 2017, Pirone et al., 2017, Jana et al., 2016, Barton et al., 2014, Kwon et al., 2013, Kwon et al., 2013, Wang et al., 2013, Habermann et al., 2012, Japanese National Institute of Genetics, 2012.5.21, Friedman et al., 2011, Harris and Ashe, 2011, Ali et al., 2010, Herranz et al., 2010, Kallappagoudar et al., 2010, Müller et al., 2010, Tan et al., 2009, Doheny et al., 2008, Spresser et al., 2008, Juhász et al., 2007, Stuart et al., 2007, Berman et al., 2004)
      Otefin
      (Kusch, 2015)
      hal
      (Barton et al., 2013)
      ote
      (Tanaka et al., 2019, Barton et al., 2016, Barton et al., 2013, Sui and Yang, 2011, Wang et al., 2011, Jiang et al., 2008, Wilmington et al., 2008)
      otefin
      (Pałka et al., 2018, Wagner et al., 2004)
      Name Synonyms
      Otefin
      (Pirone et al., 2017, Jokhi et al., 2013, Rohrbaugh et al., 2013, Milon et al., 2012, Harris and Ashe, 2011, Dialynas et al., 2010, Somma et al., 2008, Wilmington et al., 2008, Lancaster et al., 2007, Berman et al., 2004)
      halted
      haulted
      (Mohr and Gelbart, 2002)
      otefin
      (Busayavalasa et al., 2012, Habermann et al., 2012, Furukawa et al., 2009, Haussmann et al., 2008, Jiang et al., 2008, Pinto et al., 2008, Wagner et al., 2006, McHugh et al., 2004, Wagner et al., 2004, Cohen et al., 2001, Hita et al., 1999, Goldberg et al., 1998, Ashery-Padan et al., 1997, Padan et al., 1990, Harel et al., 1989)
      Secondary FlyBase IDs
      • FBgn0003022
      • FBgn0001173
      Datasets (0)
      Study focus (0)
      Experimental Role
      Project
      Project Type
      Title
      References (97)