Gene model reviewed during 5.50
Gene model reviewed during 5.44
Gene model reviewed during 5.39
There is only one protein coding transcript and one polypeptide associated with this gene
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Ote using the Feature Mapper tool.
Using EM immunogold labeling, Ote protein was localized to the nucleoplasmic side of the inner nuclear membrane.
Between stages S4 and S6-S7 of oogenesis, Ote protein localizes to the nuclear envelope of nurse cells, follicle cells and oocytes, but after stage S6-S7, nucleoplasmic and cytoplasmic accumulation is also observed. During embryogenesis, Ote protein is associated with the nucleus as well as with nonnuclear membrane vesicles. Like Lam protein, Ote protein is detected in the nuclei of most cells during larval, pupal and adult stages. Neither protein is detected in stages 6-11 of spermiogenesis. In larval and adult tissues, Ote pr tein localizes to the nuclear envelope.
GBrowse - Visual display of RNA-Seq signalsView Dmel\Ote in GBrowse 2
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for merge of: Ote hal
Ote is required autonomously for the survival of germline stem cells and non-autonomously for the maintenance of their somatic niche in both males and females.
The absence of Ote function does not cause female germ cell loss through activation of bam transcription. The primary defect in mutant female germline stem cells is a block of differentiation, which ultimately leads to germ cell death.
Ote behaves as a peripheral protein and is localised to the nucleoplasmic side of the nuclear envelope. Expression studies reveal the C-terminal 11 amino acid hydrophobic sequence is essential for targeting Ote to the nuclear periphery.
Characterisation of Ote suggests an essential role in the assembly of the nuclear envelope.
The hal locus affects early oogenesis: mutations cause the production of few, defective germ cells.
The name 'otefin' is a transliteration of the Hebrew word meaning 'envelopes'.