FB2025_01 , released February 20, 2025
Gene: Mmus\Gria1
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General Information
Symbol
Mmus\Gria1
Species
M. musculus
Name
glutamate receptor, ionotropic, AMPA1 (alpha 1)
Annotation Symbol
Feature Type
engineered_foreign_gene
FlyBase ID
FBgn0266425
Gene Model Status
Not Applicable
Stock Availability
None publicly available
Gene Summary
Contribute a Gene Snapshot for this gene.
All Summaries
Also Known As

GluR1

Key Links
Foreign Gene Data

Foreign sequence; species == Mus musculus; gene == glutamate receptor, ionotropic, AMPA1 (alpha 1); MGI:95808.

(FlyBase Curators, 1992-)
Summaries
Alleles, Insertions, Transgenic Constructs
Classical and Insertion Alleles ( 0 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 3 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Mmus\Gria1
Transgenic constructs containing regulatory region of Mmus\Gria1
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Other Phenotypes
Allele
increased cell death, with Scer\GAL4hs.2sev
Phenotype manifest in
Allele
eye, with Scer\GAL4hs.2sev
interommatidial bristle, with Scer\GAL4hs.2sev
ommatidium, with Scer\GAL4hs.2sev
photoreceptor neuron, with Scer\GAL4hs.2sev
Orthologs
Downloads
Download All DIOPT Orthologs
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Drosophila melanogaster (Fruit fly) (47)
GluRIA
12 of 14
Yes
Yes
0  
GluRIB
12 of 14
Yes
Yes
0  
clumsy
7 of 14
No
No
0  
GluRIID
7 of 14
No
No
0  
GluRIIE
7 of 14
No
No
0  
GluRIIA
6 of 14
No
No
0  
Grik
6 of 14
No
No
0  
KaiR1D
6 of 14
No
No
0  
ukar
6 of 14
No
No
0  
Ekar
5 of 14
No
No
0  
GluRIIB
5 of 14
No
No
0  
GluRIIC
5 of 14
No
No
0  
Ir25a
5 of 14
No
Yes
0  
Ir8a
4 of 14
No
Yes
0  
Ir64a
4 of 14
No
Yes
0  
Ir75a
4 of 14
No
Yes
0  
Ir75c
4 of 14
No
Yes
0  
Ir75d
4 of 14
No
Yes
0  
Ir76b
4 of 14
No
Yes
0  
Ir7c
3 of 14
No
Yes
0  
Ir7e
3 of 14
No
Yes
0  
Ir21a
3 of 14
No
Yes
0  
Ir68a
3 of 14
No
Yes
0  
Ir75b
3 of 14
No
Yes
0  
Ir84a
3 of 14
No
Yes
0  
Ir85a
3 of 14
No
Yes
0  
Ir93a
3 of 14
No
Yes
0  
Nmdar2
3 of 14
No
No
0  
Ir7a
2 of 14
No
Yes
0  
Ir7b
2 of 14
No
Yes
0  
Ir7d
2 of 14
No
Yes
0  
Ir7f
2 of 14
No
Yes
0  
Ir7g
2 of 14
No
Yes
0  
Ir40a
2 of 14
No
Yes
0  
Ir41a
2 of 14
No
Yes
0  
Ir60a
2 of 14
No
No
0  
Ir76a
2 of 14
No
Yes
0  
Ir92a
2 of 14
No
Yes
0  
Ir94d
2 of 14
No
Yes
0  
Nmdar1
2 of 14
No
No
0  
Ir10a
1 of 14
No
Yes
0  
Ir11a
1 of 14
No
Yes
0  
Ir31a
1 of 14
No
Yes
0  
Ir51b
1 of 14
No
Yes
0  
Ir67c
1 of 14
No
Yes
0  
Ir68b
1 of 14
No
No
0  
Ir100a
1 of 14
No
Yes
0  
Human Disease Associations
FlyBase Human Disease Model Reports
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 1 )
Allele
Disease
Evidence
References
Mmus\Gria1Lc.UAS
model of  brain ischemia
CEA
(Lei et al., 2017)
Potential Models Based on Orthology ( 0 )
Human Ortholog
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 1 )
Allele
Disease
Interaction
References
Mmus\Gria1Lc.UAS
model of  brain ischemia
is ameliorated by Hsp26UAS.cUa
(Lei et al., 2017)
is ameliorated by Hsp27UAS.cUa
(Lei et al., 2017)
is ameliorated by PPP1R15e02638
(Lei et al., 2017)
is ameliorated by SerRSKG03126
(Lei et al., 2017)
is ameliorated by SerRSRNAi.UAS
(Lei et al., 2017)
is ameliorated by p5311-1B-1
(Lei et al., 2017)
is exacerbated by p53UAS.cUa
(Lei et al., 2017)
Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Homo sapiens (Human)
Gene name
Score
OMIM
OMIM Phenotype
DO term
Complementation?
Transgene?
Functional Complementation Data
Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
Interactions
Summary of Physical Interactions
esyN Network Diagram
Other Interaction Browsers
Summary of Genetic Interactions
esyN Network Diagram
Other Interaction Browsers
Starting gene(s)
Interaction type
Interacting gene(s)
Reference
Starting gene(s)
Interaction type
Interacting gene(s)
Reference
External Data
Linkouts
Class of Gene
Stocks and Reagents
Stocks (0)
Other Comments
Relationship to Other Genes
Source for database merge of
Additional comments
Nomenclature History
Source for database identify of
Nomenclature comments
Etymology
Synonyms and Secondary IDs (5)
Reported As
Symbol Synonym
GluR1
(Lei et al., 2017, Hou et al., 2016, Liu et al., 2014)
Gria1
Mmus\Gria1
mGluR1
(Yang et al., 2013)
Name Synonyms
glutamate receptor, ionotropic, AMPA1 (alpha 1)
Secondary FlyBase IDs
    Datasets (0)
    Study focus (0)
    Experimental Role
    Project
    Project Type
    Title
    Study result (0)
    Result
    Result Type
    Title
    External Crossreferences and Linkouts ( 3 )
    Sequence Crossreferences
    NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
    Other crossreferences
    MARRVEL_MODEL - MARRVEL (model organism gene)
    Mouse Genome Database - The international database resource for the laboratory mouse, providing integrated genetic, genomic, and biological data to facilitate the study of human health and disease.
    References (9)