l(2)k16510, EP474, KIS-L
member of the SWI2/SNF2 family of ATP-dependent chromatin-remodeling factors - facilitates an early step in transcriptional elongation by Pol II - Kis roles include developmental patterning of the embryo, cell proliferation, eye development, synaptic transmission, axonal pruning, and memory
Please see the JBrowse view of Dmel\kis for information on other features
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AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.48
Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.
Annotated transcripts do not represent all supported alternative splices within 5' UTR.
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.39
None of the polypeptides share 100% sequence identity.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\kis using the Feature Mapper tool.
Comment: expression is uniform along A/P axis
kis protein is observed in third instar larvae in multiple motor neurons within the ventral nerve cord. It is also seen in multinucleated postsynaptic muscles.
kis protein expression is observed anterior to, within and posterior to the morphogenetic furrow in the developing retina.
Comment: cell bodies in adult brain cortex and glial sheath
GBrowse - Visual display of RNA-Seq signals
View Dmel\kis in GBrowse 2Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
polyclonal
Source for identity of: kis CG3696
Source for merge of: kis anon-WO0172774.164 anon-WO0257455.5
Source for merge of: kis l(2)k13631 l(2)k14112
Source for merge of: kis BEST:GM02209
Source for merge of: kis l(2)k16510
Source for merge of: kis l(2)k11324
Source for merge of: kis CG3660 CG18326
Source for merge of: kis EP474
snoRNA:kis-a is encoded in an intron of kis.
Annotations CG3696, CG3660 and CG18326 merged as CG3696 in release 3 of the genome annotation.
Source for merge of kis anon-WO0172774.164 anon-WO0257455.5 was sequence comparison ( date:051113 ).
Source for merge of kis l(2)k11324 was sequence comparison ( date:050921 ).
Three EMS-induced alleles have been isolated that weakly suppress the bristle and wing vein phenotypes of NAx-16.
Identification: Enhancer trap expression pattern survey for loci expressed in the ring gland.
Mutants isolated in a screen of the second chromosome identifying genes affecting disc morphology.
kis is required for the function of other homeotic genes.
Isolated as a dominant suppressor of Pc alleles. Homozygous lethal. Duplications for kismet strongly enhance the dominant Pc phenotypes. kismet mutations suppress the antennal transformations of AntpB, Antp73b and AntpNs, as well as the transformations caused by ectopic expression of Antp protein under the control of a heat-inducible promoter. kismet mutations in mitotic clones induced during larval stages transform the fifth abdominal segment into a more anterior segmental identity.
Kennison, 1984.