FB2019_05, released Oct 15, 2019

Gene: Dmel\kis

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General Information
Symbol
Dmel\kis
Species
D. melanogaster
Name
kismet
Annotation Symbol
CG3696
Feature Type
protein_coding_gene
FlyBase ID
FBgn0266557
Gene Model Status
Current
Stock Availability
60 publicly available
Gene Snapshot
kismet (kis) encodes a chromodomain containing ATP-dependent transcription factor that controls gene expression through epigenetic mechanisms. The roles of the product of kis include developmental patterning of the embryo, cell proliferation, eye development, synaptic transmission, axonal pruning, and memory. [Date last reviewed: 2019-03-14]
Other Summaries
Also Known As
l(2)k16510, EP474, KIS-L
Key Links
Genomic Location
Cytogenetic map
21B4-21B5
Sequence location
2L:210,735..250,823 [-]
Recombination map
2-0.5
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Molecular Function (GO)
[Detailed GO annotations]
Experimental Evidence
-
Predictions / Assertions
ATP binding; DNA-dependent ATPase activity
Summaries
Gene Group (FlyBase)
CHROMODOMAIN HELICASES -
The chromodomain helicase DNA-binding (CHD) family is defined by the presence of tandem N-terminal chromodomains and an SNF2-like ATPase domain. These ATP-dependent chromatin remodellers are usually components of remodelling complexes. (Adapted from FBrf0228973 and FBrf0228925).
Phenotypic Description (Red Book; Lindsley and Zimm 1992)
kis: kismet (J.A. Kennison)
Isolated as a dominant suppressor of Pc alleles. Homozygous lethal. Duplications for kismet strongly enhance the dominant Pc phenotypes. kismet mutations suppress the antennal transformations of AntpB, Antp73b, and AntpNs, as well as the transformations caused by ectopic expression of Antp protein under the control of a heat-inducible promoter. kismet mutations in mitotic clones induced during larval stages transform the fifth abdominal segment into a more anterior segmental identity.
kisS: kismet-Spradling
Summary (Interactive Fly)
member of the SWI2/SNF2 family of ATP-dependent chromatin-remodeling factors - facilitates an early step in transcriptional elongation by Pol II - Kis roles include developmental patterning of the embryo, cell proliferation, eye development, synaptic transmission, axonal pruning, and memory
Gene Model and Products
Number of Transcripts
6
Number of Unique Polypeptides
6

Please see the GBrowse view of Dmel\kis or the JBrowse view of Dmel\kis for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model
Gene model reviewed during 5.48
Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.
Annotated transcripts do not represent all supported alternative splices within 5' UTR.
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.39
Sequence Ontology: Class of Gene
gene
gene_with_edited_transcript
(Rodriguez et al., 2012, Graveley et al., 2011)
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
kis-RA
FBtr0078144
NM_078717
17943
5322
kis-RB
FBtr0078145
NM_164376
8225
2151
kis-RC
FBtr0299837
NM_001144289
18528
5517
kis-RD
FBtr0308253
NM_001258889
18006
5343
kis-RE
FBtr0308254
NM_001258890
17733
5252
kis-RF
FBtr0308255
NM_001258891
17731
5191
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
kis-PA
FBpp0077803
573.6
5322
5.52
NP_523441
AAF51527
kis-PB
FBpp0077804
224.7
2151
6.10
NP_722617
AAF51530
kis-PC
FBpp0289115
593.4
5517
5.34
NP_001137761
ACL82968
kis-PD
FBpp0300573
575.9
5343
5.56
NP_001245818
AFH03495
kis-PE
FBpp0300574
566.1
5252
5.53
NP_001245819
AFH03496
kis-PF
FBpp0300575
560.9
5191
5.53
NP_001245820
AFH03497
Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\kis using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Gene Ontology (20 terms)
Molecular Function (2 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
ATP binding
inferred from electronic annotation with InterPro:IPR000330
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
DNA-dependent ATPase activity
inferred from sequence or structural similarity with HGNC:20153
(Thompson et al., 2008)
Biological Process (16 terms)
Terms Based on Experimental Evidence (16 terms)
CV Term
Evidence
References
ATP-dependent chromatin remodeling
inferred from direct assay
(assigned by CACAO )
(Murawska et al., 2008)
axon guidance
inferred from mutant phenotype
(Melicharek et al., 2010, Berger et al., 2008)
blastoderm segmentation
inferred from mutant phenotype
(Daubresse et al., 1999)
determination of adult lifespan
inferred from mutant phenotype
(Paik et al., 2012)
heart development
inferred from mutant phenotype
(Zhu et al., 2017)
imaginal disc-derived wing morphogenesis
inferred from mutant phenotype
(Terriente-Félix et al., 2011)
locomotion
inferred from mutant phenotype
(Melicharek et al., 2010)
negative regulation of transcription by RNA polymerase II
inferred from mutant phenotype
(Thompson et al., 2008)
negative regulation of transcription, DNA-templated
inferred from mutant phenotype
(Terriente-Félix et al., 2011)
neuron remodeling
inferred from mutant phenotype
(Melicharek et al., 2010)
positive regulation of border follicle cell migration
inferred from mutant phenotype
(Mathieu et al., 2007)
positive regulation of organ growth
inferred from mutant phenotype
(Terriente-Félix et al., 2011)
positive regulation of receptor localization to synapse
inferred from mutant phenotype
(Ghosh et al., 2014)
regulation of synaptic growth at neuromuscular junction
inferred from mutant phenotype
(Ghosh et al., 2014)
segment specification
inferred from mutant phenotype
(Daubresse et al., 1999)
short-term memory
inferred from mutant phenotype
(Melicharek et al., 2010)
Terms Based on Predictions or Assertions (0 terms)
Cellular Component (2 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
nucleoplasm
inferred from high throughput direct assay
(Lye et al., 2014)
nucleus
inferred from direct assay
(Ghosh et al., 2014, Clyne et al., 2003)
Terms Based on Predictions or Assertions (0 terms)
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage
epithelial cell
(Lecuyer et al., 2007)
epithelium
(Lecuyer et al., 2007)
embryonic stage 1 -- 11
organism | ubiquitous | uniform
(Daubresse et al., 1999)
embryonic stage 16 -- 17
embryonic/larval central nervous system

Comment: expression is uniform along A/P axis

(Daubresse et al., 1999)
northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage -- pupal stage
organism
(Daubresse et al., 1999)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1 -- 9
organism
• nucleus
(Daubresse et al., 1999)
third instar larval stage
imaginal disc
• nucleus

Comment: NOT labial disc

(Daubresse et al., 1999)
embryonic/larval salivary gland
• nucleus
(Daubresse et al., 1999)
retina
(Melicharek et al., 2008)
eye disc anterior to the morphogenetic furrow
(Melicharek et al., 2008)
eye disc posterior to the morphogenetic furrow
(Melicharek et al., 2008)
morphogenetic furrow
(Melicharek et al., 2008)
ventral nerve cord | restricted
(Ghosh et al., 2014)
motor neuron
(Ghosh et al., 2014)
embryonic/larval neuromuscular junction
(Ghosh et al., 2014)
wandering third instar larval stage
embryonic/larval central nervous system
(Melicharek et al., 2010)
Kenyon cell
(Melicharek et al., 2010)
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
day 5 of adulthood & male -- day 7 of adulthood & male
spermatozoon
(Wasbrough et al., 2010)
western blot
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage
organism
(Daubresse et al., 1999)
Additional Descriptive Data
kis protein is observed in third instar larvae in multiple motor neurons within the ventral nerve cord. It is also seen in multinucleated postsynaptic muscles.
(Ghosh et al., 2014)
kis protein is broadly expressed in larval central nervous system, including in the brain lobes, the cortex, and the ventral nerve cord. kis expression is strongly colocalized with ato and da protein in these tissues.
(Melicharek et al., 2010)
kis protein expression is observed anterior to, within and posterior to the morphogenetic furrow in the developing retina.
(Melicharek et al., 2008)
Marker for
 
Subcellular Localization
CV Term
Evidence
References
nucleoplasm
inferred from high throughput direct assay
(Lye et al., 2014)
nucleus
inferred from direct assay
(Ghosh et al., 2014, Clyne et al., 2003)
Expression Deduced from Reporters
Reporter: P{PZ}kis07812
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage
organism | segmentally repeated
(Jackle and Janning, 1998.8.10)
embryonic/larval midgut
(Jackle and Janning, 1998.8.10)
embryonic/larval foregut
(Jackle and Janning, 1998.8.10)
embryonic/larval brain | presumptive
(Jackle and Janning, 1998.8.10)
stomodeum
(Jackle and Janning, 1998.8.10)
presumptive embryonic/larval central nervous system | restricted
(Jackle and Janning, 1998.8.10)
ectoderm
(Jackle and Janning, 1998.8.10)
presumptive embryonic/larval peripheral nervous system
(Jackle and Janning, 1998.8.10)
embryonic/larval hindgut
(Jackle and Janning, 1998.8.10)
amnioserosa
(Jackle and Janning, 1998.8.10)
epidermis | restricted
(Jackle and Janning, 1998.8.10)
cephalic furrow
(Jackle and Janning, 1998.8.10)
embryonic/larval proventriculus
(Jackle and Janning, 1998.8.10)
mesoderm
(Jackle and Janning, 1998.8.10)
embryonic stage 5
(Jackle and Janning, 1998.8.10)
wandering third instar larval stage
gonad
(Meister and Braun, 1995.10)
embryonic/larval hindgut
(Meister and Braun, 1995.10)
adult stage
adult central complex | restricted
(Vosshall, 1998.8.10)
adult brain | restricted
(Vosshall, 1998.8.10)
Reporter: P{ST.lexA::HG}kisSE306
Stage
Tissue/Position (including subcellular localization)
Reference
wandering third instar larval stage
embryonic/larval central nervous system
(Bloomington Drosophila Stock Center, 2019)
cell body rind of optic lobe
(Bloomington Drosophila Stock Center, 2019)
ventral nerve cord
(Bloomington Drosophila Stock Center, 2019)
midline glial cell
(Bloomington Drosophila Stock Center, 2019)
eye disc
(Bloomington Drosophila Stock Center, 2019)
photoreceptor cell
(Bloomington Drosophila Stock Center, 2019)
embryonic/larval anterior midgut
(Bloomington Drosophila Stock Center, 2019)
gastric caecum
(Bloomington Drosophila Stock Center, 2019)
Reporter: PBac{768.FSVS-0}kisCPTI003615
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult brain cell body rind

Comment: cell bodies in adult brain cortex and glial sheath

(Knowles-Barley, 2011.8.24)
adult gnathal ganglion | restricted

Comment: part of adult subesophageal ganglion

(Knowles-Barley, 2011.8.24)
Reporter: PBac{CPTI-un}kisCPTI002847
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult brain cell body rind
(Knowles-Barley, 2011.8.24)
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\kis in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 148 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 16 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of kis
Transgenic constructs containing regulatory region of kis
Deletions and Duplications ( 14 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal, with Scer\GAL429BD
lethal, with Scer\GAL4c355
lethal, with Scer\GAL4dpp.blk1
lethal, with Scer\GAL4hs.2sev
lethal (with Df(2L)ED19)
lethal (with Df(2L)ED21)
lethal | recessive
lethal - all die before end of larval stage | recessive
lethal - all die before end of pupal stage, with Scer\GAL4da.G32
lethal - all die before end of pupal stage, with Scer\GAL4elav-C155
lethal - all die during P-stage, with Scer\GAL4Mef2.PR
viable
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4da.G32
viable, with Scer\GAL4elav-C155
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4pnr-MD237
viable, with Scer\GAL4tin.CΔ4
Sterility
Allele
fertile
Other Phenotypes
Allele
decreased cell number | cell non-autonomous | larval stage | somatic clone
decreased occurrence of cell division | larval stage
flightless, with Scer\GAL4da.G32
increased cell number | adult stage, with Scer\GAL4esg.PU
increased cell number | adult stage, with Scer\GAL4esg.PU, Scer\GAL80Su(H).GBE
increased cell number | adult stage | recessive | somatic clone
increased cell number | adult stage | somatic clone, with Scer\GAL4Tub.PU
increased occurrence of cell division | adult stage, with Scer\GAL4esg.PU
increased occurrence of cell division | adult stage, with Scer\GAL4esg.PU, Scer\GAL80Su(H).GBE
increased occurrence of cell division | adult stage | recessive | somatic clone
locomotor behavior defective | adult stage, with Scer\GAL4c309
locomotor behavior defective | adult stage, with Scer\GAL4da.G32
locomotor behavior defective | adult stage, with Scer\GAL4DJ757
locomotor behavior defective | adult stage, with Scer\GAL4shot-OK307
locomotor behavior defective | third instar larval stage, with Scer\GAL4da.PU
locomotor behavior defective | third instar larval stage, with Scer\GAL4elav.PU
long lived, with Scer\GAL4da.Switch.PT
memory defective, with Scer\GAL4ey-OK107
neuroanatomy defective | adult stage | somatic clone
neuroanatomy defective | pupal stage | somatic clone
neuroanatomy defective | somatic clone | third instar larval stage
neuroanatomy defective | third instar larval stage, with Scer\GAL4da.PU
neuroanatomy defective | third instar larval stage, with Scer\GAL4elav.PU
neuroanatomy defective | third instar larval stage, with Scer\GAL4how-24B
neuroanatomy defective | third instar larval stage (with kisk13416)
neuroanatomy defective | third instar larval stage (with kisLM27)
neurophysiology defective | third instar larval stage
neurophysiology defective | third instar larval stage (with kisk13416)
neurophysiology defective | third instar larval stage (with kisLM27)
non-suppressor of variegation | dominant, with In(1)wm4
size defective | larval stage
some die during larval stage | recessive
some die during pupal stage, with Scer\GAL4da.G32
some die during pupal stage, with Scer\GAL4elav-C155
suppressor of variegation, with Dp(?;2)bwD, Scer\GAL4GMR.PF
suppressor of variegation | dominant, with P{hsp26-pt-T}39C-5
visible, with Scer\GAL4ap-md544
visible, with Scer\GAL4bbg-C96
visible, with Scer\GAL4Bx-MS1096
visible, with Scer\GAL4da.G32
visible, with Scer\GAL4elav-C155
visible, with Scer\GAL4GMR.PF
visible, with Scer\GAL4GMR.PU
visible, with Scer\GAL4pnr-MD237
visible | cell autonomous | homeotic | recessive | somatic clone
visible | dominant
visible | homeotic | recessive | somatic clone
visible | recessive
visible | recessive | somatic clone
visible | somatic clone
Phenotype manifest in
Allele
1st posterior cell | somatic clone
adult abdominal segment 5 | cell autonomous | somatic clone
adult enterocyte | somatic clone
adult enteroendocrine cell | somatic clone
adult midgut epithelium | adult stage, with Scer\GAL4esg.PU
adult midgut epithelium | adult stage, with Scer\GAL4esg.PU, Scer\GAL80Su(H).GBE
adult midgut epithelium | somatic clone
adult midgut epithelium | somatic clone, with Scer\GAL4Tub.PU
border follicle cell | somatic clone
cephalopharyngeal skeleton | germline clone
denticle belt | germline clone
dorsal cluster neuron | adult stage | somatic clone
dorsal cluster neuron | somatic clone | third instar larval stage
embryonic/larval salivary gland, with Scer\GAL4fkh.PH
embryonic abdominal segment 2 | germline clone
embryonic abdominal segment 4 | germline clone
embryonic abdominal segment 6 | germline clone
embryonic abdominal segment 8 | germline clone
embryonic head | germline clone
embryonic head | germline clone | maternal effect
embryonic mesothoracic segment | germline clone
embryonic metathoracic segment | germline clone
embryonic segment | germline clone | maternal effect
eye, with Scer\GAL4GMR.PF
eye, with Scer\GAL4GMR.PU
eye | somatic clone
eye photoreceptor cell | somatic clone | third instar larval stage
imaginal disc
intestinal stem cell | adult stage, with Scer\GAL4esg.PU
intestinal stem cell | adult stage, with Scer\GAL4esg.PU, Scer\GAL80Su(H).GBE
intestinal stem cell | adult stage | somatic clone
intestinal stem cell | adult stage | somatic clone, with Scer\GAL4Tub.PU
larval mesothoracic sensillum | embryonic stage | germline clone
larval metathoracic sensillum | embryonic stage | germline clone
leg
macrochaeta | supernumerary, with Scer\GAL4elav-C155
mesothoracic tergum, with Scer\GAL4pnr-MD237
mesothoracic ventral denticle belt | germline clone
metathoracic femur | somatic clone
metathoracic Keilin's organ | germline clone
metathoracic leg | somatic clone
metathoracic metatarsus | somatic clone
metathoracic tarsal segment 2 | somatic clone
metathoracic tarsal segment 3 | somatic clone
metathoracic tarsal segment 4 | somatic clone
metathoracic tarsal segment 5 | somatic clone
metathoracic tibia | somatic clone
metathoracic ventral denticle belt | germline clone
mushroom body alpha-lobe | adult stage | somatic clone
mushroom body beta-lobe | adult stage | somatic clone
mushroom body gamma-lobe | adult stage | somatic clone
mushroom body gamma-lobe | pupal stage | somatic clone
neuromuscular junction | third instar larval stage, with Scer\GAL4elav.PU
neuromuscular junction | third instar larval stage (with kisk13416)
neuromuscular junction | third instar larval stage (with kisLM27)
NMJ bouton | supernumerary, with Scer\GAL4da.PU
NMJ bouton | supernumerary, with Scer\GAL4how-24B
prothoracic leg anterior compartment | somatic clone
prothoracic tibial transverse row bristle | somatic clone
sex comb | somatic clone
trichogen cell, with Scer\GAL4pnr-MD237
wing, with Scer\GAL4bbg-C96
wing, with Scer\GAL4da.G32
wing | somatic clone
wing disc | cell non-autonomous | larval stage | somatic clone
wing disc | larval stage | somatic clone
wing vein, with Scer\GAL4ap-md544
wing vein | ectopic
wing vein | ectopic, with Scer\GAL4Bx-MS1096
wing vein | ectopic, with Scer\GAL4elav-C155
wing vein | ectopic | somatic clone
wing vein | somatic clone
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v7.1)
Homo sapiens (Human) (5)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\CHD7
11 of 15
Yes
Yes
Hsap\CHD6
9 of 15
No
Yes
Hsap\CHD8
9 of 15
No
Yes
Hsap\CHD9
9 of 15
No
Yes
Hsap\C17orf64
1 of 15
No
Yes
Model Organism Orthologs (via DIOPT v7.1)
Mus musculus (laboratory mouse) (6)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Chd7
10 of 15
Yes
Yes
Mmus\Chd6
9 of 15
No
Yes
Mmus\Chd9
9 of 15
No
Yes
Mmus\Chd8
7 of 15
No
Yes
Mmus\1700125H20Rik
1 of 15
No
Yes
Mmus\Muc16
1 of 15
No
Yes
Rattus norvegicus (Norway rat) (5)
Rnor\Chd7
9 of 13
Yes
Yes
Rnor\Chd8
8 of 13
No
Yes
Rnor\Chd6
6 of 13
No
Yes
Rnor\Chd9
1 of 13
No
Yes
Rnor\RGD1310166
1 of 13
No
Yes
Xenopus tropicalis (Western clawed frog) (5)
Xtro\chd6
5 of 12
Yes
Yes
Xtro\chd8
5 of 12
Yes
Yes
Xtro\chd9
5 of 12
Yes
Yes
Xtro\chd1
1 of 12
No
No
Xtro\chd2
1 of 12
No
No
Danio rerio (Zebrafish) (6)
Drer\chd8
10 of 15
Yes
Yes
Drer\chd7
8 of 15
No
Yes
Drer\chd6
7 of 15
No
Yes
Drer\chd9
5 of 15
No
Yes
Drer\chd1
1 of 15
No
No
Drer\chd2
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (1)
Cele\chd-7
11 of 15
Yes
Yes
Arabidopsis thaliana (thale-cress) (1)
Atha\PKL
1 of 9
Yes
No
Saccharomyces cerevisiae (Brewer's yeast) (1)
Scer\CHD1
3 of 15
Yes
No
Schizosaccharomyces pombe (Fission yeast) (1)
Spom\hrp3
1 of 12
Yes
No
Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG0919002M )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila melanogaster
fruit fly
Dmel\kis
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00000018
Drosophila simulans
Dsim\GD22978
Drosophila sechellia
Dsec\GM16690
Drosophila erecta
Dere\GG24671
Drosophila yakuba
Dyak\GE16349
Drosophila ananassae
Dana\GF24504
Drosophila pseudoobscura pseudoobscura
Dpse\GA17619
Drosophila persimilis
Dper\GL25835
Drosophila persimilis
Dper\GL25836
Drosophila willistoni
Dwil\GK18181
Drosophila virilis
Dvir\GJ17250
Drosophila grimshawi
Dgri\GH10228
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG0915001G )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17015222
Musca domestica
House fly
Mdoa\17006230
Glossina morsitans
Tsetse fly
Gmor\GMOY001860
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_13755
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_05154
Mayetiola destructor
Hessian fly
Mdes\Mdes009851
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL002230
Anopheles darlingi
American malaria mosquito
Adar\ADAC010332
Anopheles gambiae
Malaria mosquito
Agam\AGAP008482
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ003506
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W001I )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA005925
Danaus plexippus
Monarch butterfly
Dple\DPOGS214202-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL006822
Apis florea
Little honeybee
Aflo\2529247780
Apis mellifera
Western honey bee
Amel\GB51962
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP19149
Bombus terrestris
Buff-tailed bumblebee
Bter\15213076
Linepithema humile
Argentine ant
Lhum\LH20703
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:000764
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG008050
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG008051
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_06319
Tribolium castaneum
Red flour beetle
Tcas\TC014275
Pediculus humanus
Human body louse
Phum\PHUM249060
Rhodnius prolixus
Kissing bug
Rpro\RPRC001988
Cimex lectularius
Bed bug
Clec\CLEC005212
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI005853
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_11520
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X002A )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR008413
Ixodes scapularis
Black-legged tick
Isca\ISCW018963
Stegodyphus mimosarum
African social velvet spider
Smim\KFM59802.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM59803.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur37g00490
Tetranychus urticae
Two-spotted spider mite
Turt\tetur37g00420
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_319863
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G003J )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000003893
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v7.1)
Drosophila melanogaster (Fruit fly) (3)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
Chd1
2 of 10
Chd3
2 of 10
Mi-2
2 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
Disease Model Summary Ribbon
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 4 )
Potential Models Based on Orthology ( 2 )
Modifiers Based on Experimental Evidence ( 3 )
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease Associations of Human Orthologs (via DIOPT v7.1 and OMIM)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Homo sapiens (Human)
Gene name
Score
OMIM
OMIM Phenotype
DO term
Complementation?
Transgene?
CHD7; chromodomain helicase DNA binding protein 7
11 of 15
608892
CHD6; chromodomain helicase DNA binding protein 6
9 of 15
616114
      CHD8; chromodomain helicase DNA binding protein 8
      9 of 15
      610528
        CHD9; chromodomain helicase DNA binding protein 9
        9 of 15
        616936
            Functional Complementation Data
            Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
            Interactions
            Summary of Physical Interactions
            Summary of Genetic Interactions
            esyN Network Diagram
            esyN Network Key:
            Suppression
            Enhancement
            View in Interactions Browser
            Please look at the allele data for full details of the genetic interactions
            Starting gene(s)
            Interaction type
            Interacting gene(s)
            Reference
            kis
            suppressible
            bsk
            (Gervais et al., 2019)
            kis
            suppressible
            Cbl
            (Gervais et al., 2019)
            kis
            suppressible
            cic
            (Gervais et al., 2019)
            kis
            suppressible
            dome
            (Gervais et al., 2019)
            kis
            suppressible
            Egfr
            (Gervais et al., 2019)
            kis
            suppressible
            EloA
            (Rougeot et al., 2013)
            kis
            suppressible
            EloC
            (Rougeot et al., 2013)
            kis
            suppressible
            InR
            (Gervais et al., 2019)
            kis
            suppressible
            N
            (Gervais et al., 2019)
            kis
            suppressible
            yki
            (Gervais et al., 2019)
            Starting gene(s)
            Interaction type
            Interacting gene(s)
            Reference
            ato
            enhanceable
            kis
            (Melicharek et al., 2008)
            bw
            suppressible
            kis
            (Schneiderman et al., 2010)
            Dg
            enhanceable
            kis
            (Kucherenko et al., 2008)
            dom
            suppressible
            kis
            (Ellis et al., 2015)
            Dys
            suppressible
            kis
            (Kucherenko et al., 2008)
            E2f1
            suppressible
            kis
            (Ji et al., 2012)
            ksr::tor
            enhanceable
            kis
            (Therrien et al., 2000)
            Marcal1
            suppressible
            kis
            (Morimoto et al., 2016)
            Marcal1
            enhanceable
            kis
            (Morimoto et al., 2016)
            N
            enhanceable
            kis
            (Verheyen et al., 1996)
            pbl
            enhanceable
            kis
            (Gregory et al., 2007)
            Pc
            suppressible
            kis
            (Kennison and Tamkun, 1988)
            pnr
            suppressible
            kis
            (Pena-Rangel et al., 2002)
            pnr
            enhanceable
            kis
            (Pena-Rangel et al., 2002)
            RacGAP84C
            enhanceable
            kis
            (Raymond et al., 2004)
            Raf
            enhanceable
            kis
            (Therrien et al., 2000)
            Ras85D
            suppressible
            kis
            (Therrien et al., 2000)
            Ras85D|sev
            suppressible
            kis
            (Maixner et al., 1998)
            Ret
            suppressible
            kis
            (Read et al., 2005)
            Snr1
            enhanceable
            kis
            (Marenda et al., 2004)
            Syx1A
            suppressible
            kis
            (van Swinderen and Greenspan, 2005)
            tna
            enhanceable
            kis
            (Gutierrez et al., 2003)
            trr
            enhanceable
            kis
            (Gervais et al., 2019)
            w
            enhanceable
            kis
            (Bloyer et al., 2003)
            External Data
            Linkouts
            DroID - A comprehensive database of gene and protein interactions.
            MIST (genetic) - An integrated Molecular Interaction Database
            MIST (protein-protein) - An integrated Molecular Interaction Database
            Pathways
            Gene Group - Pathway Membership (FlyBase)
            External Data
            Linkouts
            Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
            Genomic Location and Detailed Mapping Data
            Chromosome (arm)
            2L
            Recombination map
            2-0.5
            Cytogenetic map
            21B4-21B5
            Sequence location
            2L:210,735..250,823 [-]
            FlyBase Computed Cytological Location
            Cytogenetic map
            Evidence for location
            21B4-21B5
            Limits computationally determined from genome sequence between P{lacW}spenk06805&P{lacW}l(2)k13604k13604 and P{lacW}U2af38k14504
            Experimentally Determined Cytological Location
            Cytogenetic map
            Notes
            References
            21B6-21B7
            (Therrien, 1999.12.13, Daubresse, 1998.12.14)
            Location from complementation analysis with deficiency and duplication chromosomes (details unspecified).
            (Kennison and Tamkun, 1988)
            21B4-21B6
            (determined by in situ hybridisation) 21C1--2 (determined by in situ hybridisation)
            (Spradling et al., 1999)
            21B-21B
            (determined by in situ hybridisation)
            (Roch et al., 1998)
            21B-21B
            (Gellon et al., 1997)
            21B4-21B6
            21B4--7 21B6--7 21B7--8 21C1--2
            (BDGP Project Members, 1994-1999)
            21B6-21B8
            (Kennison and Tamkun, 1988)
            Experimentally Determined Recombination Data
            Location
            2-0.5
            (FlyBase, 2016)
            2-0.0
            (Comeron et al., 2012)
            2-0
            (Kennison and Tamkun, 1988)
            Left of (cM)
            Right of (cM)
            Notes
            Stocks and Reagents
            Stocks (60)
            Genomic Clones (30)
            cDNA Clones (82)
             

            Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

            cDNA clones, fully sequences
            BDGP DGC clones
            Other clones
            Drosophila Genomics Resource Center cDNA clones

            For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

            cDNA Clones, End Sequenced (ESTs)
            BDGP DGC clones
            Other clones
            RNAi and Array Information
            Linkouts
            GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
            Antibody Information
            Laboratory Generated Antibodies
             
            polyclonal
            (Mazina et al., 2018, Daubresse et al., 1999)
            Commercially Available Antibodies
             
            Other Information
            Relationship to Other Genes
            Source for database identify of
            Source for identity of: kis CG3696
            (Guan, 1999.11)
            Source for database merge of
            Source for merge of: kis anon-WO0172774.164 anon-WO0257455.5
            (FlyBase, 1996-)
            Source for merge of: kis l(2)k13631 l(2)k14112
            (BDGP Project Members, 1994-1999)
            Source for merge of: kis BEST:GM02209
            (Bayraktaroglu, 2000.11.2)
            Source for merge of: kis l(2)k16510
            (Read et al., 2005)
            Source for merge of: kis l(2)k11324
            (FlyBase, 1996-)
            Source for merge of: kis CG3660 CG18326
            (FlyBase Genome Annotators, 2002-2003)
            Source for merge of: kis EP474
            (Maybeck and Röper, 2009)
            Additional comments
            snoRNA:kis-a is encoded in an intron of kis.
            (Graveley et al., 2011)
            mir-965 is located within kis.
            (Stark et al., 2007)
            Annotations CG3696, CG3660 and CG18326 merged as CG3696 in release 3 of the genome annotation.
            (FlyBase Genome Annotators, 2002-2003)
            Source for merge of kis anon-WO0172774.164 anon-WO0257455.5 was sequence comparison ( date:051113 ).
            (FlyBase, 1996-)
            Source for merge of kis l(2)k11324 was sequence comparison ( date:050921 ).
            (FlyBase, 1996-)
            Other Comments
            RNAi screen using dsRNA made from templates generated with primers directed against this gene causes a greater than three-fold increase in AttA activity in response to heat-killed E.coli after ecdysone treatment in S2 cells.
            (Kleino et al., 2005)
            Loss of zygotic kis function causes homeotic transformations. Loss of maternal kis function causes segmentation defects similar to those caused by mutations in pair-rule genes.
            (Daubresse et al., 1999)
            Three EMS-induced alleles have been isolated that weakly suppress the bristle and wing vein phenotypes of NAx-16.
            (Go and Artavanis-Tsakonas, 1998)
            Identification: Enhancer trap expression pattern survey for loci expressed in the ring gland.
            (Harvie et al., 1998)
            Mutants isolated in a screen of the second chromosome identifying genes affecting disc morphology.
            (Roch et al., 1998)
            Identified in a screen for modifiers of the Dfd13/Dfd3 mutant phenotype. Mutants also interact with Pc.
            (Gellon et al., 1997)
            kis is required for the function of other homeotic genes.
            (Gellon et al., 1995)
            Sections of the Scr regulatory region may be important for regulation of Scr by Polycomb- and trithorax-group genes.
            (Gindhart and Kaufman, 1995)
            kis is one of the 18 loci identified in a screen for dominant modifiers of Pc and/or Antp phenotypes. Mosaic analysis with mutant alleles reveals homeotic transformations in adult cuticle.
            (Kennison and Tamkun, 1988)
            Isolated as a dominant suppressor of Pc alleles. Homozygous lethal. Duplications for kismet strongly enhance the dominant Pc phenotypes. kismet mutations suppress the antennal transformations of AntpB, Antp73b and AntpNs, as well as the transformations caused by ectopic expression of Antp protein under the control of a heat-inducible promoter. kismet mutations in mitotic clones induced during larval stages transform the fifth abdominal segment into a more anterior segmental identity.
            Origin and Etymology
            Discoverer
            Kennison, 1984.
            Etymology
            Identification
            External Crossreferences and Linkouts ( 87 )
            Sequence Crossreferences
            NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
            GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
            GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
            RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
            UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
            Other crossreferences
            Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
            Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
            Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
            GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
            iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
            InterPro - A database of protein families, domains and functional sites
            KEGG Genes - Molecular building blocks of life in the genomic space.
            Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
            Linkouts
            DroID - A comprehensive database of gene and protein interactions.
            Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
            MIST (genetic) - An integrated Molecular Interaction Database
            MIST (protein-protein) - An integrated Molecular Interaction Database
            Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
            Synonyms and Secondary IDs (39)
            Reported As
            Symbol Synonym
            136/31
            (Roch et al., 1998)
            2532
            (Harvie et al., 1998)
            5841
            (Harvie et al., 1998)
            BEST:GM02209
            CG18326
            CG3660
            (Eissenberg, 2001)
            CG3696
            (Hosono et al., 2015, Hadar et al., 2012, Mast et al., 2011, Ni et al., 2011.7.19, Ni et al., 2010.12.1, Schneiderman et al., 2010, Keleman et al., 2009.8.5, Schneiderman et al., 2009, Berger et al., 2008, Hughes et al., 2008, Grieder et al., 2007)
            DmelPex20
            (Mast et al., 2011)
            EC2-7
            (Baril et al., 2014)
            EK2-4
            (Therrien et al., 2000)
            EP(2)0474
            (Pena-Rangel et al., 2002)
            EP474
            FBtr0078144
            (Li et al., 2012)
            GM02209
            (Toba et al., 1999)
            KIS
            (Kingston and Tamkun, 2014, Fasulo et al., 2012, Tie et al., 2012, Mills, 2010, McDaniel et al., 2008, Corona et al., 2001)
            KIS-L
            (Schuettengruber et al., 2011, Srinivasan et al., 2008)
            Kis
            (Maini et al., 2017, Horvath et al., 2016, Ghasemi et al., 2015, Nikalayevich and Ohkura, 2015, Ji et al., 2012, Secombe et al., 2007)
            Pex20
            (Mast et al., 2011)
            Su(Pc)21AB
            anon-WO0172774.164
            anon-WO0257455.5
            kis
            (Gervais et al., 2019, Kockel et al., 2019, Latcheva et al., 2019, Dasari et al., 2018, Latcheva et al., 2018, Lee et al., 2018, Sharma et al., 2017, Transgenic RNAi Project members, 2017-, Clandinin and Owens, 2016-, Gene Disruption Project members, 2016-, Morimoto et al., 2016, Van Bortle et al., 2015, Verma and Cohen, 2015, Ashwal-Fluss et al., 2014, Baril et al., 2014, Ghosh et al., 2014, Dorighi and Tamkun, 2013, Kwon et al., 2013, Rougeot et al., 2013, Vasanthi et al., 2013, Hadar et al., 2012, Hainaut et al., 2012, Japanese National Institute of Genetics, 2012.5.21, Paik et al., 2012, Rodriguez et al., 2012, Winbush et al., 2012, Curtis et al., 2011, Di Stefano et al., 2011, Friedman et al., 2011, Friedman et al., 2011, Graveley et al., 2011, Terriente-Félix et al., 2011, Arancio et al., 2010, Bhatia et al., 2010, Gan et al., 2010, Karam et al., 2010, Mudiganti et al., 2010, Schneiderman et al., 2010, Terriente-Félix et al., 2010, Wasbrough et al., 2010, Dubruille et al., 2009, Schneiderman et al., 2009, Berger et al., 2008, Doheny et al., 2008, Font-Burgada et al., 2008, Kucherenko et al., 2008, Melicharek et al., 2008, Petruk et al., 2008, Srinivasan et al., 2008, Vázquez et al., 2008, Buszczak et al., 2007, Grieder et al., 2007, Ivaldi et al., 2007, Kankel et al., 2007, Lecuyer et al., 2007, Stark et al., 2007, Edwards et al., 2006, Raymond et al., 2004, Daubresse et al., 1999)
            kiss
            (Bejarano and Busturia, 2004)
            l(2)07812
            l(2)k08827
            l(2)k11324
            l(2)k13631
            (BDGP Project Members, 1994-1999)
            l(2)k14112
            (BDGP Project Members, 1994-1999)
            l(2)k16510
            (Spradling, 1999.12.9, Spradling et al., 1999)
            l(2)s3527
            l(2)s4771
            l(2)s4793
            Name Synonyms
            EP474
            KISMET
            (Ellis et al., 2015)
            Kismet
            (Zhu et al., 2017, Kingston and Tamkun, 2014, Dorighi and Tamkun, 2013, Nakayama et al., 2012, Dorighi et al., 2008, Armstrong et al., 2007, Schuettengruber et al., 2007, Graves and Tamkun, 2006, Papp and Muller, 2006)
            Kismet-L
            (Mazina et al., 2017)
            Peroxin 20
            (Mast et al., 2011)
            kismet
            (Iyer et al., 2016, Verma and Cohen, 2015, Chen et al., 2014, Fasulo et al., 2012, Paik et al., 2012, Davis et al., 2011, Singer and Gall, 2011, Terriente-Félix et al., 2011, Melicharek et al., 2010, Schneiderman et al., 2010, Terriente-Félix et al., 2010, Dubruille et al., 2009, Berger et al., 2008, Doheny et al., 2008, Fisher et al., 2008, Marenda et al., 2008, Melicharek et al., 2008, Srinivasan et al., 2008, Thompson et al., 2008, Gregory et al., 2007, Kankel et al., 2007, Mathieu et al., 2007, Robin et al., 2007, Secombe et al., 2007, Edwards et al., 2006, Raymond et al., 2004, Daubresse et al., 1999, Gellon et al., 1997)
            lethal (2) k11324
            lethal (2) k16510
            Secondary FlyBase IDs
            • FBgn0062647
            • FBgn0086902
            • FBgn0010642
            • FBgn0010689
            • FBgn0010697
            • FBgn0010698
            • FBgn0021918
            • FBgn0026596
            • FBgn0031234
            • FBgn0031236
            • FBgn0046436
            • FBgn0063789
            • FBgn0021813
            • FBgn0001309
            Datasets (0)
            Study focus (0)
            Experimental Role
            Project
            Project Type
            Title
            References (224)