FlyBase Gene Report: Dmel\kis

General Information

Symbol

Dmel\kis

Species

D. melanogaster

Name

kismet

Annotation Symbol

CG3696

Feature Type

protein_coding_gene

FlyBase ID

FBgn0266557

Gene Model Status

Stock Availability

52 publicly available

Gene Summary

kismet (kis) encodes a chromodomain containing ATP-dependent transcription factor that controls gene expression through epigenetic mechanisms. The roles of the product of kis include developmental patterning of the embryo, cell proliferation, eye development, synaptic transmission, axonal pruning, and memory. [Date last reviewed: 2019-03-14] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
Red Book
Interactive Fly

Also Known As

l(2)k16510, KIS-L, EP474

Key Links

Genomic Location

Cytogenetic map

Sequence location

2L:210,735..250,823 [-]

Recombination map

2-0.5

RefSeq locus

NT_033779 REGION:210735..250823

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse GBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

Gene Ontology (GO) Annotations (20 terms)

Molecular Function (2 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

enables ATP binding

inferred from electronic annotation with InterPro:IPR000330

(assigned by InterPro )

(FlyBase Curators et al., 2004-)

enables DNA-dependent ATPase activity

inferred from sequence or structural similarity with HGNC:20153

(Thompson et al., 2008)

Biological Process (16 terms)

Terms Based on Experimental Evidence (16 terms)

CV Term

Evidence

References

involved_in ATP-dependent chromatin remodeling

inferred from direct assay

(assigned by CACAO )

(Murawska et al., 2008)

involved_in axon guidance

inferred from mutant phenotype

(Melicharek et al., 2010)

involved_in blastoderm segmentation

inferred from mutant phenotype

(Daubresse et al., 1999)

involved_in determination of adult lifespan

inferred from mutant phenotype

(Paik et al., 2012)

involved_in heart development

inferred from mutant phenotype

(Zhu et al., 2017)

involved_in imaginal disc-derived wing morphogenesis

inferred from mutant phenotype

(Terriente-Félix et al., 2011)

involved_in locomotion

inferred from mutant phenotype

(Melicharek et al., 2010)

involved_in negative regulation of transcription by RNA polymerase II

inferred from mutant phenotype

(Thompson et al., 2008)

involved_in negative regulation of transcription, DNA-templated

inferred from mutant phenotype

(Terriente-Félix et al., 2011)

involved_in neuron remodeling

inferred from mutant phenotype

(Melicharek et al., 2010)

involved_in positive regulation of border follicle cell migration

inferred from mutant phenotype

(Mathieu et al., 2007)

involved_in positive regulation of organ growth

inferred from mutant phenotype

(Terriente-Félix et al., 2011)

involved_in positive regulation of receptor localization to synapse

inferred from mutant phenotype

(Ghosh et al., 2014)

involved_in regulation of synaptic growth at neuromuscular junction

inferred from mutant phenotype

(Ghosh et al., 2014)

involved_in segment specification

inferred from mutant phenotype

(Daubresse et al., 1999)

involved_in short-term memory

inferred from mutant phenotype

(Melicharek et al., 2010)

Terms Based on Predictions or Assertions (0 terms)

Cellular Component (2 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

located_in nucleoplasm

inferred from high throughput direct assay

(Lye et al., 2014)

located_in nucleus

inferred from direct assay

(Ghosh et al., 2014, Clyne et al., 2003)

Terms Based on Predictions or Assertions (0 terms)

Gene Group (FlyBase)

SNF2-LIKE CHROMATIN REMODELERS

Protein Family (UniProt)

-

Protein Signatures (InterPro)

Summaries

Gene Snapshot

kismet (kis) encodes a chromodomain containing ATP-dependent transcription factor that controls gene expression through epigenetic mechanisms. The roles of the product of kis include developmental patterning of the embryo, cell proliferation, eye development, synaptic transmission, axonal pruning, and memory. [Date last reviewed: 2019-03-14]

Gene Group (FlyBase)

SNF2-LIKE CHROMATIN REMODELERS -: Snf2-like chromatin remodelers are a family of helicase-like proteins that direct energy derived from ATP hydrolysis into the mechanical remodelling of chromatin structure. They are so-called due to the presence of a domain homologous to the helicase-like ATPase domain of the S. cerevisiae Snf2 protein. This domain, the Snf2 domain, consists of two tandem RecA-like folds and contains seven conserved helicase-related sequence motifs that classify it as part of the helicase superfamily 2 (SF2). However, Snf2 proteins are not bona fide helicases, lacking the ability to separate nucleic acid strands. Instead, Snf2 proteins are DNA translocases that apply an ATP-dependent torsional strain to DNA, which provides the necessary force to remodel nucleosomes or in some cases other DNA-protein complexes. (Adapted from PMID:21862382.)

Phenotypic Description (Red Book; Lindsley and Zimm 1992)

kis: kismet (J.A. Kennison)

Isolated as a dominant suppressor of Pc alleles. Homozygous lethal. Duplications for kismet strongly enhance the dominant Pc phenotypes. kismet mutations suppress the antennal transformations of AntpB, Antp73b, and AntpNs, as well as the transformations caused by ectopic expression of Antp protein under the control of a heat-inducible promoter. kismet mutations in mitotic clones induced during larval stages transform the fifth abdominal segment into a more anterior segmental identity.

kisS: kismet-Spradling

Summary (Interactive Fly)

member of the SWI2/SNF2 family of ATP-dependent chromatin-remodeling factors - facilitates an early step in transcriptional elongation by Pol II - Kis roles include developmental patterning of the embryo, cell proliferation, eye development, synaptic transmission, axonal pruning, and memory

Interactive Fly

Gene Model and Products

Number of Transcripts

6

Number of Unique Polypeptides

6

Please see the JBrowse view of Dmel\kis for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Comments on Gene Model

Gene model reviewed during 5.48

Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.

Annotated transcripts do not represent all supported alternative splices within 5' UTR.

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.39

Sequence Ontology: Class of Gene

gene_with_edited_transcript

(Rodriguez et al., 2012, Graveley et al., 2011)

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

FBtr0078144

17943

5322

FBtr0078145

8225

2151

FBtr0299837

18528

5517

FBtr0308253

18006

5343

FBtr0308254

17733

5252

FBtr0308255

17731

5191

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

FBpp0077803

573.6

5322

5.52

FBpp0077804

224.7

2151

6.10

FBpp0289115

593.4

5517

5.34

FBpp0300573

575.9

5343

5.56

FBpp0300574

566.1

5252

5.53

FBpp0300575

560.9

5191

5.53

Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\kis using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

kis_1
kis_2

Linkouts

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage

epithelial cell

• cytoplasm | basal

(Lecuyer et al., 2007)

• cytoplasm | basal

(Lecuyer et al., 2007)

embryonic stage 1 -- 11

organism | ubiquitous | uniform

(Daubresse et al., 1999)

embryonic stage 16 -- 17

embryonic/larval central nervous system

Comment: expression is uniform along A/P axis

(Daubresse et al., 1999)

northern blot

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage -- pupal stage

(Daubresse et al., 1999)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 9

• nucleus

(Daubresse et al., 1999)

wandering third instar larval stage

embryonic/larval central nervous system

(Melicharek et al., 2010)

(Melicharek et al., 2010)

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

• membrane

(Aradska et al., 2015)

day 5 of adulthood & male -- day 7 of adulthood & male

(Wasbrough et al., 2010)

western blot

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage

(Daubresse et al., 1999)

Additional Descriptive Data

kis protein is observed in third instar larvae in multiple motor neurons within the ventral nerve cord. It is also seen in multinucleated postsynaptic muscles.

(Ghosh et al., 2014)

kis protein is broadly expressed in larval central nervous system, including in the brain lobes, the cortex, and the ventral nerve cord. kis expression is strongly colocalized with ato and da protein in these tissues.

(Melicharek et al., 2010)

kis protein expression is observed anterior to, within and posterior to the morphogenetic furrow in the developing retina.

(Melicharek et al., 2008)

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in nucleoplasm

inferred from high throughput direct assay

(Lye et al., 2014)

located_in nucleus

inferred from direct assay

(Ghosh et al., 2014, Clyne et al., 2003)

Expression Deduced from Reporters

Reporter: P{PZ}kis⁰⁷⁸¹²

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 5

(Jackle and Janning, 1998.8.10)

wandering third instar larval stage

(Meister and Braun, 1995.10)

embryonic/larval hindgut

(Meister and Braun, 1995.10)

adult central complex | restricted

(Vosshall, 1998.8.10)

adult brain | restricted

(Vosshall, 1998.8.10)

Reporter: P{ST.lexA::HG}kis^SE306

Stage

Tissue/Position (including subcellular localization)

Reference

wandering third instar larval stage

embryonic/larval central nervous system

(Bloomington Drosophila Stock Center, 2019)

cell body rind of adult optic lobe

(Bloomington Drosophila Stock Center, 2019)

larval ventral nerve cord

(Bloomington Drosophila Stock Center, 2019)

midline glial cell

(Bloomington Drosophila Stock Center, 2019)

(Bloomington Drosophila Stock Center, 2019)

photoreceptor cell

(Bloomington Drosophila Stock Center, 2019)

embryonic/larval anterior midgut

(Bloomington Drosophila Stock Center, 2019)

(Bloomington Drosophila Stock Center, 2019)

Reporter: PBac{768.FSVS-0}kis^CPTI003615

Stage

Tissue/Position (including subcellular localization)

Reference

adult brain cell body rind

Comment: cell bodies in adult brain cortex and glial sheath

(Knowles-Barley, 2011.8.24)

adult gnathal ganglion | restricted

Comment: part of adult subesophageal ganglion

(Knowles-Barley, 2011.8.24)

Reporter: PBac{CPTI-un}kis^CPTI002847

Stage

Tissue/Position (including subcellular localization)

Reference

adult brain cell body rind

(Knowles-Barley, 2011.8.24)

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\kis in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\kis

View exonic expression by tissue for Dmel\kis

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG3696

Images

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 148 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 16 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of kis

Transgenic constructs containing regulatory region of kis

Aberrations (Deficiencies and Duplications) ( 14 )

Inferred from experimentation ( 14 )

Gene disrupted in

(Miller et al., 2020, Kahsai et al., 2016)

(Kahsai et al., 2016)

(Ryder, 2004.4.26)

(Daubresse et al., 1999)

(Therrien et al., 2000, Daubresse et al., 1999, Spradling et al., 1999, Netter et al., 1998, BDGP Project Members, 1994-1999)

(BDGP Project Members, 1994-1999)

Gene duplicated in

(Daubresse et al., 1999)

Ts(YLt;2Lt)L124

(Srinivasan et al., 2005)

Gene not disrupted in

(Spradling et al., 1999, BDGP Project Members, 1994-1999)

(Therrien et al., 2000)

Df(2L)net-PM29A

(Daubresse et al., 1999)

Df(2L)net-PM47C

(Daubresse et al., 1999, BDGP Project Members, 1994-1999)

(BDGP Project Members, 1994-1999)

(Daubresse et al., 1999)

(BDGP Project Members, 1994-1999)

Inferred from location ( 0 )

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal, with Scer\GAL4^29BD

kis^GS2067

lethal, with Scer\GAL4^c355

kis^GS2067

lethal, with Scer\GAL4^dpp.blk1

kis^GS2067

lethal, with Scer\GAL4^hs.2sev

kis^GS2067

lethal (with Df(2L)ED19)

kis¹

lethal (with Df(2L)ED21)

lethal - all die before end of larval stage | recessive

lethal - all die before end of pupal stage, with Scer\GAL4^da.G32

lethal - all die before end of pupal stage, with Scer\GAL4^elav-C155

kis^GD16331

lethal - all die during P-stage, with Scer\GAL4^Mef2.PR

kis^GD16331

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

kis^GD16331

viable, with Scer\GAL4^da.G32

kis^GD4510

viable, with Scer\GAL4^elav-C155

kis^GD4510

viable, with Scer\GAL4^Mef2.PR

kis^GD4510

viable, with Scer\GAL4^pnr-MD237

viable, with Scer\GAL4^tin.CΔ4

kis^GD16331

Sterility

Allele

kis^EY12846

Other Phenotypes

Allele

abnormal locomotor behavior | adult stage, with Scer\GAL4^c309

kis^GD16331

abnormal locomotor behavior | adult stage, with Scer\GAL4^da.G32

kis^GD4510

abnormal locomotor behavior | adult stage, with Scer\GAL4^DJ757

kis^GD16331

abnormal locomotor behavior | adult stage, with Scer\GAL4^shot-OK307

kis^GD16331

abnormal locomotor behavior | third instar larval stage, with Scer\GAL4^da.PU

kis^GD16331

abnormal locomotor behavior | third instar larval stage, with Scer\GAL4^elav.PU

kis^GD16331

abnormal memory, with Scer\GAL4^ey-OK107

abnormal neuroanatomy | adult stage | somatic clone

kis^LM27

abnormal neuroanatomy | pupal stage | somatic clone

kis^LM27

abnormal neuroanatomy | somatic clone | third instar larval stage

kis^LM27

abnormal neuroanatomy | third instar larval stage, with Scer\GAL4^da.PU

kis^GD16331

abnormal neuroanatomy | third instar larval stage, with Scer\GAL4^elav.PU

kis^GD16331

abnormal neuroanatomy | third instar larval stage, with Scer\GAL4^how-24B

kis^GD16331

abnormal neuroanatomy | third instar larval stage (with kis^k13416)

kis^LM27

abnormal neuroanatomy | third instar larval stage (with kis^LM27)

kis^k13416

abnormal neurophysiology | third instar larval stage

kis^k13416

abnormal neurophysiology | third instar larval stage (with kis^k13416)

kis^LM27

abnormal neurophysiology | third instar larval stage (with kis^LM27)

kis^k13416

abnormal size | larval stage

kis^k04513

decreased cell number | cell non-autonomous | larval stage | somatic clone

kis^k04513

decreased occurrence of cell division | larval stage

kis^k04513

flightless, with Scer\GAL4^da.G32

kis^GD4510

increased cell number | adult stage, with Scer\GAL4^esg.PU

kis^GL00557

increased cell number | adult stage, with Scer\GAL4^esg.PU, Scer\GAL80^Su(H).GBE

increased cell number | adult stage | recessive | somatic clone

increased cell number | adult stage | somatic clone, with Scer\GAL4^Tub.PU

increased occurrence of cell division | adult stage, with Scer\GAL4^esg.PU

kis^GL00557

increased occurrence of cell division | adult stage, with Scer\GAL4^esg.PU, Scer\GAL80^Su(H).GBE

kis^GL00557

increased occurrence of cell division | adult stage | recessive | somatic clone

kis^10D26

long lived, with Scer\GAL4^da.Switch.PT

non-suppressor of variegation | dominant, with In(1)w^m4

kis¹

some die during larval stage | recessive

some die during pupal stage, with Scer\GAL4^da.G32

kis^GD16331

some die during pupal stage, with Scer\GAL4^elav-C155

kis^GD16331

suppressor of variegation, with Dp(?;2)bw^D, Scer\GAL4^GMR.PF

kis^EY12846

suppressor of variegation | dominant, with P{hsp26-pt-T}39C-5

kis¹

visible, with Scer\GAL4^ap-md544

kis^NIG.3696R

visible, with Scer\GAL4^bbg-C96

kis^HMS01254

visible, with Scer\GAL4^Bx-MS1096

kis^NIG.3696R

visible, with Scer\GAL4^da.G32

kis^GD4510

visible, with Scer\GAL4^elav-C155

kis^GD4510

visible, with Scer\GAL4^GMR.PF

kis^GD16331

visible, with Scer\GAL4^GMR.PU

kis^GD16331

visible, with Scer\GAL4^pnr-MD237

visible | cell autonomous | homeotic | recessive | somatic clone

kis²

visible | dominant

kis¹

visible | homeotic | recessive | somatic clone

visible | recessive

kis^k08827

visible | recessive | somatic clone

visible | somatic clone

kis¹

Phenotype manifest in

Allele

1st posterior cell | somatic clone

adult abdominal segment 5 | cell autonomous | somatic clone

adult enterocyte | somatic clone

kis^10D26

adult enteroendocrine cell | somatic clone

kis^10D26

adult midgut epithelium | adult stage, with Scer\GAL4^esg.PU

kis^GL00557

adult midgut epithelium | adult stage, with Scer\GAL4^esg.PU, Scer\GAL80^Su(H).GBE

kis^GL00557

adult midgut epithelium | somatic clone

adult midgut epithelium | somatic clone, with Scer\GAL4^Tub.PU

adult mushroom body alpha-lobe | adult stage | somatic clone

kis^LM27

adult mushroom body beta-lobe | adult stage | somatic clone

kis^LM27

adult mushroom body gamma-lobe | adult stage | somatic clone

kis^LM27

adult mushroom body gamma-lobe | pupal stage | somatic clone

kis^LM27

border follicle cell | somatic clone

cephalopharyngeal skeleton | germline clone

kis¹

denticle belt | germline clone

kis¹

dorsal cluster neuron | adult stage | somatic clone

kis^LM27

dorsal cluster neuron | somatic clone | third instar larval stage

kis^LM27

embryonic/larval salivary gland, with Scer\GAL4^fkh.PH

kis^EP474

embryonic abdominal segment 2 | germline clone

kis¹

embryonic abdominal segment 4 | germline clone

kis¹

embryonic abdominal segment 6 | germline clone

kis¹

embryonic abdominal segment 8 | germline clone

kis¹

embryonic head | germline clone

kis¹

embryonic head | germline clone | maternal effect

kis^2L-89-19

embryonic mesothoracic segment | germline clone

kis¹

embryonic metathoracic segment | germline clone

kis¹

embryonic segment | germline clone | maternal effect

kis^2L-89-19

eye, with Scer\GAL4^GMR.PF

kis^GD16331

eye, with Scer\GAL4^GMR.PU

kis^GD16331

eye | somatic clone

kis¹

eye photoreceptor cell | somatic clone | third instar larval stage

kis^LM27

intestinal stem cell | adult stage, with Scer\GAL4^esg.PU

kis^GL00557

intestinal stem cell | adult stage, with Scer\GAL4^esg.PU, Scer\GAL80^Su(H).GBE

intestinal stem cell | adult stage | somatic clone

intestinal stem cell | adult stage | somatic clone, with Scer\GAL4^Tub.PU

larval mesothoracic sensillum | embryonic stage | germline clone

kis¹

larval metathoracic sensillum | embryonic stage | germline clone

kis¹

kis^k08827

macrochaeta | increased number, with Scer\GAL4^elav-C155

kis^GD4510

mesothoracic tergum, with Scer\GAL4^pnr-MD237

kis^GD16331

mesothoracic ventral denticle belt | germline clone

kis¹

metathoracic femur | somatic clone

metathoracic Keilin's organ | germline clone

kis¹

metathoracic leg | somatic clone

metathoracic metatarsus | somatic clone

metathoracic tarsal segment 2 | somatic clone

metathoracic tarsal segment 3 | somatic clone

metathoracic tarsal segment 4 | somatic clone

metathoracic tarsal segment 5 | somatic clone

metathoracic tibia | somatic clone

metathoracic ventral denticle belt | germline clone

kis¹

neuromuscular junction | third instar larval stage, with Scer\GAL4^elav.PU

kis^GD16331

neuromuscular junction | third instar larval stage (with kis^k13416)

kis^LM27

neuromuscular junction | third instar larval stage (with kis^LM27)

kis^k13416

NMJ bouton | increased number, with Scer\GAL4^da.PU

kis^GD16331

NMJ bouton | increased number, with Scer\GAL4^how-24B

kis^GD16331

prothoracic leg anterior compartment | somatic clone

kis^S

prothoracic tibial transverse row bristle | somatic clone

kis^S

sex comb | somatic clone

kis^S

trichogen cell, with Scer\GAL4^pnr-MD237

wing, with Scer\GAL4^bbg-C96

kis^HMS01254

wing, with Scer\GAL4^da.G32

kis^GD4510

wing | somatic clone

wing disc | cell non-autonomous | larval stage | somatic clone

kis^k04513

wing disc | larval stage | somatic clone

kis^k04513

wing vein, with Scer\GAL4^ap-md544

kis^NIG.3696R

wing vein | ectopic

kis¹

wing vein | ectopic, with Scer\GAL4^Bx-MS1096

kis^NIG.3696R

wing vein | ectopic, with Scer\GAL4^elav-C155

kis^GD4510

wing vein | ectopic | somatic clone

wing vein | somatic clone

kis^k04513

Orthologs

Downloads

Download All DIOPT Orthologs

Download All OrthoDB Orthologs

Human Orthologs (via DIOPT v8.0)

Homo sapiens (Human) (10)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

10 of 15

Yes

Yes

9 of 15

No

Yes

9 of 15

No

Yes

9 of 15

No

Yes

1 of 15

No

Yes

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

Model Organism Orthologs (via DIOPT v8.0)

Mus musculus (laboratory mouse) (9)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

10 of 15

Yes

Yes

10 of 15

Yes

Yes

9 of 15

No

Yes

9 of 15

No

Yes

Mmus\1700125H20Rik

1 of 15

No

Yes

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

Rattus norvegicus (Norway rat) (10)

9 of 13

Yes

Yes

9 of 13

Yes

Yes

8 of 13

No

Yes

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

Yes

Rnor\RGD1310166

1 of 13

No

Yes

Xenopus tropicalis (Western clawed frog) (11)

8 of 12

Yes

Yes

5 of 12

No

Yes

3 of 12

No

Yes

1 of 12

No

No

1 of 12

No

No

1 of 12

No

No

1 of 12

No

No

1 of 12

No

No

1 of 12

No

No

1 of 12

No

Yes

Xtro\LOC101733299

1 of 12

No

Yes

Danio rerio (Zebrafish) (10)

10 of 15

Yes

Yes

9 of 15

No

Yes

8 of 15

No

Yes

6 of 15

No

Yes

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

Caenorhabditis elegans (Nematode, roundworm) (3)

12 of 15

Yes

Yes

1 of 15

No

No

1 of 15

No

No

Arabidopsis thaliana (thale-cress) (3)

2 of 9

Yes

No

1 of 9

No

No

1 of 9

No

No

Saccharomyces cerevisiae (Brewer's yeast) (1)

2 of 15

Yes

No

Schizosaccharomyces pombe (Fission yeast) (1)

1 of 12

Yes

No

Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG0919002M )

Organism

Common Name

Gene

AAA Syntenic Ortholog

Multiple Dmel Genes in this Orthologous Group

Drosophila suzukii

Spotted wing Drosophila

Dsuz\DS10_00000018

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Drosophila persimilis

Drosophila persimilis

Drosophila willistoni

Drosophila virilis

Drosophila grimshawi

Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG0915001G )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Musca domestica

House fly

Musca domestica

House fly

Glossina morsitans

Tsetse fly

Gmor\GMOY001860

Lucilia cuprina

Australian sheep blowfly

Lcup\FF38_13755

Lucilia cuprina

Australian sheep blowfly

Lcup\FF38_05154

Mayetiola destructor

Hessian fly

Mdes\Mdes009851

Aedes aegypti

Yellow fever mosquito

Aaeg\AAEL002230

Anopheles darlingi

American malaria mosquito

Adar\ADAC010332

Anopheles gambiae

Malaria mosquito

Agam\AGAP008482

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ003506

Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W001I )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Bombyx mori

Silkmoth

Bmor\BGIBMGA005925

Danaus plexippus

Monarch butterfly

Dple\DPOGS214202-PA

Heliconius melpomene

Postman butterfly

Hmel\HMEL006822

Apis florea

Little honeybee

Aflo\2529247780

Apis mellifera

Western honey bee

Bombus impatiens

Common eastern bumble bee

Bombus terrestris

Buff-tailed bumblebee

Linepithema humile

Argentine ant

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:000764

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG008050

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG008051

Dendroctonus ponderosae

Mountain pine beetle

Tribolium castaneum

Red flour beetle

Pediculus humanus

Human body louse

Phum\PHUM249060

Rhodnius prolixus

Kissing bug

Rpro\RPRC001988

Cimex lectularius

Bed bug

Clec\CLEC005212

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI005853

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_11520

Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X002A )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strigamia maritima

European centipede

Smar\SMAR008413

Ixodes scapularis

Black-legged tick

Isca\ISCW018963

Stegodyphus mimosarum

African social velvet spider

Smim\KFM59802.1

Stegodyphus mimosarum

African social velvet spider

Smim\KFM59803.1

Tetranychus urticae

Two-spotted spider mite

Turt\tetur37g00490

Tetranychus urticae

Two-spotted spider mite

Turt\tetur37g00420

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_319863

Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G003J )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Ciona intestinalis

Vase tunicate

Cint\ENSCING00000003893

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v8.0)

Drosophila melanogaster (Fruit fly) (16)

Gene Symbol

Score

Source

Alignment

3 of 10

3 of 10

3 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 4 )

Allele

Disease

Evidence

References

model of CHARGE syndrome

CEA with kis^LM27

(Ghosh et al., 2014)

CEA

(Ghosh et al., 2014)

model of CHARGE syndrome

CEA

(Melicharek et al., 2010)

model of congenital heart disease

CEA

(Zhu et al., 2017)

model of CHARGE syndrome

CEA

(Ghosh et al., 2014, Melicharek et al., 2010)

model of congenital heart disease

CEA

(Zhu et al., 2017)

model of CHARGE syndrome

CEA

(Melicharek et al., 2010, Melicharek et al., 2008)

CEA with kis^k13416

(Ghosh et al., 2014)

Potential Models Based on Orthology ( 2 )

Human Ortholog

Disease

Evidence

References

CHD7; chromodomain helicase DNA binding protein 7

model of CHARGE syndrome

IEA

(FlyBase, 2019-)

model of hypogonadotropic hypogonadism 5 with or without anosmia

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 3 )

Allele

Disease

Interaction

References

ameliorates multiple endocrine neoplasia type 2B

modeled by Ret^MEN2B.GMR

(Read et al., 2005)

ameliorates multiple endocrine neoplasia type 2A

modeled by Ret^MEN2A.GMR

(Read et al., 2005)

ameliorates multiple endocrine neoplasia type 2B

modeled by Ret^MEN2B.GMR

(Read et al., 2005)

ameliorates multiple endocrine neoplasia type 2B

modeled by Ret^MEN2B.GMR

(Read et al., 2005)

Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

CHD7; chromodomain helicase DNA binding protein 7

10 of 15

CHD6; chromodomain helicase DNA binding protein 6

9 of 15

CHD8; chromodomain helicase DNA binding protein 8

9 of 15

AUTISM, SUSCEPTIBILITY TO, 18; AUTS18

CHD9; chromodomain helicase DNA binding protein 9

9 of 15

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

View in Interactions Browser

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

anti bait coimmunoprecipitation, western blot, Identification by mass spectrometry

(Horvath et al., 2016)

anti tag coimmunoprecipitation, peptide massfingerprinting

(Nakayama et al., 2012)

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Summary of Genetic Interactions

esyN Network Diagram

esyN Network Key:

Suppression

Enhancement

View in Interactions Browser

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

suppressible

(Gervais et al., 2019)

suppressible

(Gervais et al., 2019)

suppressible

(Gervais et al., 2019)

suppressible

(Gervais et al., 2019)

suppressible

(Gervais et al., 2019)

suppressible

(Rougeot et al., 2013)

suppressible

(Rougeot et al., 2013)

suppressible

(Gervais et al., 2019)

suppressible

(Gervais et al., 2019)

suppressible

(Gervais et al., 2019)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

enhanceable

(Melicharek et al., 2008)

suppressible

(Schneiderman et al., 2010)

enhanceable

(Kucherenko et al., 2008)

suppressible

(Ellis et al., 2015)

suppressible

(Kucherenko et al., 2008)

suppressible

(Ji et al., 2012)

enhanceable

(Therrien et al., 2000)

enhanceable

(Morimoto et al., 2016)

suppressible

(Morimoto et al., 2016)

enhanceable

(Verheyen et al., 1996)

enhanceable

(Gregory et al., 2007)

suppressible

(Kennison and Tamkun, 1988)

enhanceable

(Pena-Rangel et al., 2002)

suppressible

(Pena-Rangel et al., 2002)

enhanceable

(Raymond et al., 2004)

enhanceable

(Therrien et al., 2000)

suppressible

(Therrien et al., 2000)

suppressible

(Maixner et al., 1998)

suppressible

(Read et al., 2005)

enhanceable

(Marenda et al., 2004)

suppressible

(van Swinderen and Greenspan, 2005)

enhanceable

(Gutierrez et al., 2003)

enhanceable

(Gervais et al., 2019)

enhanceable

(Bloyer et al., 2003)

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0266557

MIST (genetic) - An integrated Molecular Interaction Database

kis

MIST (protein-protein) - An integrated Molecular Interaction Database

kis

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

External Data

Linkouts

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Deactivation of the beta-catenin transactivating complex

Genomic Location and Detailed Mapping Data

Chromosome (arm)

2L

Recombination map

2-0.5

Cytogenetic map

Sequence location

2L:210,735..250,823 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

21B4-21B5

Limits computationally determined from genome sequence between P{lacW}spen^k06805&P{lacW}l(2)k13604^k13604 and P{lacW}U2af38^k14504

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

21B6-21B7

(Therrien, 1999.12.13, Daubresse, 1998.12.14)

Location from complementation analysis with deficiency and duplication chromosomes (details unspecified).

(Kennison and Tamkun, 1988)

21B4-21B6

(determined by in situ hybridisation) 21C1--2 (determined by in situ hybridisation)

(Spradling et al., 1999)

21B-21B

(determined by in situ hybridisation)

(Roch et al., 1998)

21B-21B

(Gellon et al., 1997)

21B4-21B6

21B4--7 21B6--7 21B7--8 21C1--2

(BDGP Project Members, 1994-1999)

21B6-21B8

(Kennison and Tamkun, 1988)

Experimentally Determined Recombination Data

Location

2-0.5

(FlyBase, 2016)

2-0.0

(Comeron et al., 2012)

2-0

(Kennison and Tamkun, 1988)

Left of (cM)

Right of (cM)

net

Notes

Stocks and Reagents

Stocks (52)

124060

w¹¹¹⁸; P{RS3}kis^CB-6339-3

124344

w¹¹¹⁸; P{RS3}kis^UM-8106-3

124496

w¹¹¹⁸; P{RS3}kis^UM-8357-3

125107

w¹¹¹⁸; P{RS5}kis^5-HA-1148

125298

w¹¹¹⁸; P{RS5}kis^5-HA-1614

125347

w¹¹¹⁸; P{RS5}kis^5-HA-1691

125591

w¹¹¹⁸; P{RS5}kis^5-HA-2299

125743

w¹¹¹⁸; P{RS5}kis^5-HA-2916

125791

w¹¹¹⁸; P{RS5}kis^5-HA-3065

125921

w¹¹¹⁸; P{RS5}kis^5-SZ-3153

v109414

P{KK100890}VIE-260B

v46685

w¹¹¹⁸; P{GD16331}v46685

More stocks available...

Genomic Clones (30)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (82)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

IP15878

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0266557

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

33185

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Mazina et al., 2018, Daubresse et al., 1999)

Commercially Available Antibodies

Other Information

Relationship to Other Genes

Source for database identify of

Source for identity of: kis CG3696

(Guan, 1999.11)

Source for database merge of

Source for merge of: kis anon-WO0172774.164 anon-WO0257455.5

(FlyBase, 1996-)

Source for merge of: kis l(2)k13631 l(2)k14112

(BDGP Project Members, 1994-1999)

Source for merge of: kis BEST:GM02209

(Bayraktaroglu, 2000.11.2)

Source for merge of: kis l(2)k16510

(Read et al., 2005)

Source for merge of: kis l(2)k11324

(FlyBase, 1996-)

Source for merge of: kis CG3660 CG18326

(FlyBase Genome Annotators, 2002-2003)

Source for merge of: kis EP474

(Maybeck and Röper, 2009)

Additional comments

snoRNA:kis-a is encoded in an intron of kis.

(Graveley et al., 2011)

mir-965 is located within kis.

(Stark et al., 2007)

Annotations CG3696, CG3660 and CG18326 merged as CG3696 in release 3 of the genome annotation.

(FlyBase Genome Annotators, 2002-2003)

Source for merge of kis anon-WO0172774.164 anon-WO0257455.5 was sequence comparison ( date:051113 ).

(FlyBase, 1996-)

Source for merge of kis l(2)k11324 was sequence comparison ( date:050921 ).

(FlyBase, 1996-)

Other Comments

RNAi screen using dsRNA made from templates generated with primers directed against this gene causes a greater than three-fold increase in AttA activity in response to heat-killed E.coli after ecdysone treatment in S2 cells.

(Kleino et al., 2005)

Loss of zygotic kis function causes homeotic transformations. Loss of maternal kis function causes segmentation defects similar to those caused by mutations in pair-rule genes.

(Daubresse et al., 1999)

Three EMS-induced alleles have been isolated that weakly suppress the bristle and wing vein phenotypes of N^Ax-16.

(Go and Artavanis-Tsakonas, 1998)

Identification: Enhancer trap expression pattern survey for loci expressed in the ring gland.

(Harvie et al., 1998)

Mutants isolated in a screen of the second chromosome identifying genes affecting disc morphology.

(Roch et al., 1998)

Identified in a screen for modifiers of the Dfd¹³/Dfd³ mutant phenotype. Mutants also interact with Pc.

(Gellon et al., 1997)

kis is required for the function of other homeotic genes.

(Gellon et al., 1995)

Sections of the Scr regulatory region may be important for regulation of Scr by Polycomb- and trithorax-group genes.

(Gindhart and Kaufman, 1995)

kis is one of the 18 loci identified in a screen for dominant modifiers of Pc and/or Antp phenotypes. Mosaic analysis with mutant alleles reveals homeotic transformations in adult cuticle.

(Kennison and Tamkun, 1988)

Isolated as a dominant suppressor of Pc alleles. Homozygous lethal. Duplications for kismet strongly enhance the dominant Pc phenotypes. kismet mutations suppress the antennal transformations of Antp^B, Antp^73b and Antp^Ns, as well as the transformations caused by ectopic expression of Antp protein under the control of a heat-inducible promoter. kismet mutations in mitotic clones induced during larval stages transform the fifth abdominal segment into a more anterior segmental identity.

Origin and Etymology

Discoverer

Kennison, 1984.

Etymology

Identification

External Crossreferences and Linkouts ( 86 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

33185

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0266557

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

kis_1
kis_2

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG3696

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

33185

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC014275

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

Dmel_CG3696

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0266557

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

MIST (genetic) - An integrated Molecular Interaction Database

kis

MIST (protein-protein) - An integrated Molecular Interaction Database

kis

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Deactivation of the beta-catenin transactivating complex

Synonyms and Secondary IDs (39)

Reported As

Symbol Synonym

136/31

(Roch et al., 1998)

2532

(Harvie et al., 1998)

5841

(Harvie et al., 1998)

BEST:GM02209

CG18326

CG3660

(Eissenberg, 2001)

CG3696

(Hosono et al., 2015, Hadar et al., 2012, Mast et al., 2011, Ni et al., 2011.7.19, Ni et al., 2010.12.1, Schneiderman et al., 2010, Keleman et al., 2009.8.5, Schneiderman et al., 2009, Berger et al., 2008, Hughes et al., 2008, Grieder et al., 2007)

DmelPex20

(Mast et al., 2011)

EC2-7

(Baril et al., 2014)

EK2-4

(Therrien et al., 2000)

EP(2)0474

(Pena-Rangel et al., 2002)

EP474

FBtr0078144

(Li et al., 2012)

GM02209

(Toba et al., 1999)

KIS

(Kingston and Tamkun, 2014, Fasulo et al., 2012, Tie et al., 2012, Mills, 2010, McDaniel et al., 2008, Corona et al., 2001)

KIS-L

(Schuettengruber et al., 2011, Srinivasan et al., 2008)

Kis

(Maini et al., 2017, Horvath et al., 2016, Ghasemi et al., 2015, Nikalayevich and Ohkura, 2015, Ji et al., 2012, Secombe et al., 2007)

Kismet

(Mariano et al., 2020)

Pex20

(Mast et al., 2011)

Su(Pc)21AB

anon-WO0172774.164

anon-WO0257455.5

kis

(Aboukilila et al., 2020, Singh et al., 2020, Yusuff et al., 2020, Gervais et al., 2019, Kockel et al., 2019, Latcheva et al., 2019, Latcheva et al., 2019, Dasari et al., 2018, Latcheva et al., 2018, Lee et al., 2018, Sharma et al., 2017, Transgenic RNAi Project members, 2017-, Clandinin and Owens, 2016-, Gene Disruption Project members, 2016-, Morimoto et al., 2016, Van Bortle et al., 2015, Verma and Cohen, 2015, Ashwal-Fluss et al., 2014, Baril et al., 2014, Ghosh et al., 2014, Dorighi and Tamkun, 2013, Kwon et al., 2013, Rougeot et al., 2013, Vasanthi et al., 2013, Hadar et al., 2012, Hainaut et al., 2012, Japanese National Institute of Genetics, 2012.5.21, Paik et al., 2012, Rodriguez et al., 2012, Winbush et al., 2012, Curtis et al., 2011, Di Stefano et al., 2011, Friedman et al., 2011, Friedman et al., 2011, Graveley et al., 2011, Terriente-Félix et al., 2011, Arancio et al., 2010, Bhatia et al., 2010, Gan et al., 2010, Karam et al., 2010, Mudiganti et al., 2010, Schneiderman et al., 2010, Terriente-Félix et al., 2010, Wasbrough et al., 2010, Dubruille et al., 2009, Schneiderman et al., 2009, Berger et al., 2008, Doheny et al., 2008, Font-Burgada et al., 2008, Kucherenko et al., 2008, Melicharek et al., 2008, Petruk et al., 2008, Srinivasan et al., 2008, Vázquez et al., 2008, Buszczak et al., 2007, Chang et al., 2007, Grieder et al., 2007, Ivaldi et al., 2007, Kankel et al., 2007, Lecuyer et al., 2007, Stark et al., 2007, Edwards et al., 2006, Raymond et al., 2004, Daubresse et al., 1999)

kiss

(Bejarano and Busturia, 2004)

l(2)07812

l(2)k08827

l(2)k11324

l(2)k13631

(BDGP Project Members, 1994-1999)

l(2)k14112

(BDGP Project Members, 1994-1999)

l(2)k16510

(Spradling, 1999.12.9, Spradling et al., 1999)

l(2)s3527

l(2)s4771

l(2)s4793

Name Synonyms

EP474

KISMET

(Ellis et al., 2015)

Kismet

(Zhu et al., 2017, Kingston and Tamkun, 2014, Dorighi and Tamkun, 2013, Nakayama et al., 2012, Dorighi et al., 2008, Armstrong et al., 2007, Schuettengruber et al., 2007, Graves and Tamkun, 2006, Papp and Muller, 2006)

Kismet-L

(Mazina et al., 2017)

Peroxin 20

(Mast et al., 2011)

lethal (2) k11324

lethal (2) k16510

Secondary FlyBase IDs

FBgn0062647
FBgn0086902
FBgn0010642
FBgn0010689
FBgn0010697
FBgn0010698
FBgn0021918
FBgn0026596
FBgn0031234
FBgn0031236
FBgn0046436
FBgn0063789
FBgn0021813
FBgn0001309

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

References (234)