FB2020_03, released Jun 16, 2020

Gene: Dmel\ebo

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General Information
Symbol
Dmel\ebo
Species
D. melanogaster
Name
ellipsoid body open
Annotation Symbol
CG3923
Feature Type
protein_coding_gene
FlyBase ID
FBgn0266572
Gene Model Status
Current
Stock Availability
5 publicly available
Gene Snapshot
ellipsoid body open (ebo) encodes a protein that complexes with actin, the product of chic, and Ran-GTPase to mediate actin nuclear export. Loss of ebo during development results in defects in the ellipsoid body of the central complex. In the adult brain, accumulation of nuclear actin results in the inhibition of the product of bs and subsequent loss of visual orientation memory. [Date last reviewed: 2019-03-07]
Other Summaries
Also Known As

Exp6, EG:165H7.3 , Exportin 6

Key Links
Genomic Location
Cytogenetic map
1B4-1B4
Sequence location
X:471,019..476,579 [-]
Recombination map

1-0

RefSeq locus
NC_004354 REGION:471019..476579
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (7 terms)
Molecular Function (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
Ran GTPase binding
inferred from electronic annotation with InterPro:IPR001494
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
Biological Process (6 terms)
Terms Based on Experimental Evidence (4 terms)
CV Term
Evidence
References
central complex development
inferred from mutant phenotype
(Renn et al., 1999)
flight behavior
inferred from mutant phenotype
(Ilius et al., 1994)
mushroom body development
inferred from mutant phenotype
(de Belle and Heisenberg, 1996)
short-term memory
inferred from mutant phenotype
(Thran et al., 2013)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
adult walking behavior
traceable author statement
(Ilius et al., 1994)
protein export from nucleus
inferred from biological aspect of ancestor with PANTHER:PTN001087101
(assigned by GO_Central )
(Gaudet et al., 2011)
Cellular Component (0 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (0 terms)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Phenotypic Description (Red Book; Lindsley and Zimm 1992)
l(1)1Bb
Homozygous clones in eyes display swelling and vacuolization of pigment cells (alleles designated MM2 and TE10). Deletion for l(1)1Bb enhances central-nervous-system and eye effects of ASC deficiencies (Jimenez and Campos-Ortega, 1987, J. Neurogenet. 4: 179-200; Gonzalez, Romani, Cubas, Modolell, and Campuzano, 1989, EMBO J. 8: 3553-62).
Gene Model and Products
Number of Transcripts
3
Number of Unique Polypeptides
3

Please see the GBrowse view of Dmel\ebo or the JBrowse view of Dmel\ebo for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Gene model reviewed during 5.49

Low-frequency RNA-Seq exon junction(s) not annotated.

Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.

Sequence Ontology: Class of Gene
gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
ebo-RA
FBtr0070098
NM_080140
4142
1047
ebo-RB
FBtr0339442
NM_001297809
4160
1053
ebo-RC
FBtr0339443
NM_001297810
4163
1054
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
ebo-PA
FBpp0070093
117.8
1047
5.86
NP_524879
AAF45504
ebo-PB
FBpp0308528
118.6
1053
5.86
NP_001284738
AHN59209
ebo-PC
FBpp0308529
118.6
1054
5.86
NP_001284739
AHN59210
Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Nucleotide / Polypeptide Records
 
UniProt
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\ebo using the Feature Mapper tool.

External Data
Crossreferences
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\ebo in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 8 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 4 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of ebo
Transgenic constructs containing regulatory region of ebo
Deletions and Duplications ( 1 )
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (3)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\XPO6
12 of 15
Yes
Yes
Hsap\XPO1
1 of 15
No
No
Hsap\XPO5
1 of 15
No
No
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (3)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Xpo6
11 of 15
Yes
Yes
Mmus\Xpo1
1 of 15
No
No
Mmus\Xpo5
1 of 15
No
No
Rattus norvegicus (Norway rat) (3)
Rnor\Xpo6
11 of 13
Yes
Yes
Rnor\Xpo1
1 of 13
No
No
Rnor\Xpo5
1 of 13
No
No
Xenopus tropicalis (Western clawed frog) (4)
Xtro\xpo6
7 of 12
Yes
Yes
Xtro\exd3
1 of 12
No
No
Xtro\xpo1
1 of 12
No
No
Xtro\xpo5
1 of 12
No
No
Danio rerio (Zebrafish) (4)
Drer\xpo6
12 of 15
Yes
Yes
Drer\xpo1a
1 of 15
No
No
Drer\xpo1b
1 of 15
No
No
Drer\xpo5
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (0)
No records found.
Arabidopsis thaliana (thale-cress) (0)
No records found.
Saccharomyces cerevisiae (Brewer's yeast) (2)
Scer\CRM1
1 of 15
Yes
No
Scer\MSN5
1 of 15
Yes
No
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG091901Z5 )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00005309
Drosophila simulans
Dsim\GD28369
Drosophila sechellia
Dsec\GM12987
Drosophila erecta
Dere\Exp6
Drosophila yakuba
Dyak\Exp6
Drosophila ananassae
Dana\GF20811
Drosophila pseudoobscura pseudoobscura
Dpse\GA26716
Drosophila persimilis
Dper\GL20168
Drosophila willistoni
Dwil\GK25657
Drosophila virilis
Dvir\GJ15980
Drosophila mojavensis
Dmoj\GI11122
Drosophila grimshawi
Dgri\GH24622
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091500TN )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17017770
Glossina morsitans
Tsetse fly
Gmor\GMOY002724
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_13790
Mayetiola destructor
Hessian fly
Mdes\Mdes011531
Mayetiola destructor
Hessian fly
Mdes\Mdes014979
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL003789
Anopheles darlingi
American malaria mosquito
Adar\ADAC006281
Anopheles gambiae
Malaria mosquito
Agam\AGAP000271
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ017442
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W02PD )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA005326
Danaus plexippus
Monarch butterfly
Dple\DPOGS207771-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL017570
Apis florea
Little honeybee
Aflo\2554446532
Apis mellifera
Western honey bee
Amel\GB55700
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP13313
Bombus terrestris
Buff-tailed bumblebee
Bter\15206598
Linepithema humile
Argentine ant
Lhum\LH13516
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:000ffc
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_05592
Tribolium castaneum
Red flour beetle
Tcas\TC006436
Pediculus humanus
Human body louse
Phum\PHUM179230
Rhodnius prolixus
Kissing bug
Rpro\RPRC001270
Cimex lectularius
Bed bug
Clec\CLEC005062
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI007314
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_01770
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X02MN )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Ixodes scapularis
Black-legged tick
Isca\ISCW021128
Stegodyphus mimosarum
African social velvet spider
Smim\KFM76173.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM76171.1
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_324545
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G040W )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\SPU_023250gn
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Xpo6
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Xpo6_1
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000006884
Gallus gallus
Domestic chicken
Ggal\XPO6
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (2)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
emb
1 of 10
Ranbp21
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    XPO6; exportin 6
    12 of 15
    608411
        Functional Complementation Data
        Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
        Interactions
        Summary of Physical Interactions
        esyN Network Diagram
        Interactions Browser
        Summary of Genetic Interactions
        esyN Network Diagram
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        External Data
        Linkouts
        MIST (protein-protein) - An integrated Molecular Interaction Database
        Pathways
        Signaling Pathways (FlyBase)
        Metabolic Pathways
        External Data
        Linkouts
        Genomic Location and Detailed Mapping Data
        Chromosome (arm)
        X
        Recombination map

        1-0

        Cytogenetic map
        1B4-1B4
        Sequence location
        X:471,019..476,579 [-]
        FlyBase Computed Cytological Location
        Cytogenetic map
        Evidence for location
        1B4-1B4
        Limits computationally determined from genome sequence between P{EP}CG17896EP1320&P{EP}EP1398 and P{EP}svrEP356&P{EP}argEP452
        Experimentally Determined Cytological Location
        Cytogenetic map
        Notes
        References
        Experimentally Determined Recombination Data
        Location

        1-0

        (FlyBase, 2016)

        1-0.0

        (Comeron et al., 2012)

        1-3.8

        (Varnam et al., 1996)
        Left of (cM)
        Right of (cM)
        (Ilius et al., 1993)
        Notes
        Stocks and Reagents
        Stocks (5)
        Genomic Clones (8)
         

        Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

        cDNA Clones (245)
         

        Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

        cDNA clones, fully sequenced
        BDGP DGC clones
        Other clones
        Drosophila Genomics Resource Center cDNA clones

        For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

        cDNA Clones, End Sequenced (ESTs)
        BDGP DGC clones
        Other clones
        RNAi and Array Information
        Linkouts
        GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
        Antibody Information
        Laboratory Generated Antibodies
         
        Commercially Available Antibodies
         
        Other Information
        Relationship to Other Genes
        Source for database identify of
        Source for database merge of

        Source for merge of: Exp6 ebo

        (Thran et al., 2013)
        Additional comments

        l(1)1Bb19 complements ebo678, indicating that l(1)1Bb and ebo are not members of the same complementation group.

        (Poeck, 2014.3.8)

        The l(1)1Bb complementation group was previously merged with the ebo gene in FlyBase, based on information in FBrf0125093 (which provided molecular map information for the region including ebo and information about changes in the restriction enzyme map of this region in l(1)1Bb mutants). However, FBrf0224496 shows that the l(1)1Bb19 allele complements ebo mutant alleles. Thus l(1)1Bb and ebo have been split back out into separate gene records in FlyBase.

        (FlyBase, 1992-)
        Other Comments

        ebo is required for central complex formation.

        (Fleischmann et al., 1995)
        Origin and Etymology
        Discoverer
        Etymology
        Identification
        External Crossreferences and Linkouts ( 38 )
        Sequence Crossreferences
        NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
        GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
        GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
        RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
        UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
        Other crossreferences
        Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
        Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
        GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
        iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
        InterPro - A database of protein families, domains and functional sites
        KEGG Genes - Molecular building blocks of life in the genomic space.
        Linkouts
        MIST (protein-protein) - An integrated Molecular Interaction Database
        Synonyms and Secondary IDs (10)
        Datasets (0)
        Study focus (0)
        Experimental Role
        Project
        Project Type
        Title
        References (60)