FB2025_01 , released February 20, 2025
Gene: Dmel\Gp210
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General Information
Symbol
Dmel\Gp210
Species
D. melanogaster
Name
Glycoprotein 210 kDa
Annotation Symbol
CG7897
Feature Type
protein_coding_gene
FlyBase ID
FBgn0266580
Gene Model Status
Current
Stock Availability
10 publicly available
Gene Summary
Glycoprotein 210 kDa (Gp210) encodes a glycoprotein of the nuclear pore complex. [Date last reviewed: 2019-07-11] (FlyBase Gene Snapshot)
All Summaries
Key Links
Genomic Location
Cytogenetic map
41F9-41F10
Sequence location
Recombination map
2-55
RefSeq locus
NT_033778 REGION:5760862..5774324
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (7 terms)
Molecular Function (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (0 terms)
Biological Process (2 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
involved_in nuclear pore organization
inferred from sequence or structural similarity with SGD:S000004736
(Gene Ontology Curators, 2002-)
involved_in protein import into nucleus
inferred from sequence or structural similarity with SGD:S000004736
(Gene Ontology Curators, 2002-)
Cellular Component (5 terms)
Terms Based on Experimental Evidence (4 terms)
CV Term
Evidence
References
located_in cytoplasm
inferred from direct assay
(Harel et al., 1989)
part_of nuclear pore inner ring
inferred from direct assay
(Sabri et al., 2007)
part_of nuclear pore nuclear basket
inferred from direct assay
(Sabri et al., 2007)
part_of nuclear pore
inferred from direct assay
(Harel et al., 1989)
inferred from direct assay
(Filson et al., 1985)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
part_of nuclear pore transmembrane ring
inferred from sequence or structural similarity with SGD:S000004736
(Gene Ontology Curators, 2002-)
part_of nuclear pore
inferred from biological aspect of ancestor with PANTHER:PTN000545169
(GO Reference Genome Project, 2011-)
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the NUP210 family. (A1Z6H7)
Protein Signatures (InterPro)
Summaries
Gene Snapshot
Glycoprotein 210 kDa (Gp210) encodes a glycoprotein of the nuclear pore complex. [Date last reviewed: 2019-07-11]
Gene Group (FlyBase)
NUCLEAR PORE COMPLEX -
The Nuclear Pore Complex (NPC) is a large protein complex embedded in the nuclear membrane that facilitates nucleocytoplasmic traffic. The NPC is composed of approximately 30 different proteins: the nucleoporins. The NPC displays 8-fold symmetry and each nucleoporin is present in multiple copies. From the central ring that forms the pore, filaments protrude into the cytoplasm (cytoplasmic filaments) and the nucleoplasm (nuclear basket). Many nucleoporins contain FG repeats which are thought to act as a diffusion barrier and docking sight for transport receptors (karyopherins). Export and import is controlled by the interaction of the karyopherins with localization and export sequences. (Adapted from FBrf0220062 and PMID:21495847).
Protein Function (UniProtKB)
Component of the nuclear pore complex.
(UniProt, A1Z6H7)
Gene Model and Products
Number of Transcripts
2
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\Gp210 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry A1Z6H7)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Gene model reviewed during 5.47

Low-frequency RNA-Seq exon junction(s) not annotated.

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Gp210-RA
FBtr0086044
NM_136340
5969
1876
Gp210-RB
FBtr0335270
NM_001273785
7801
1876
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
Gp210-PA
FBpp0085380
209.8
1876
6.44
A1Z6H7
NP_610184
AAF57309
Gp210-PB
FBpp0307249
209.8
1876
6.44
A1Z6H7
NP_001260714
AGB93249
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

1876 aa isoforms: Gp210-PA, Gp210-PB
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Post Translational Modification

Glycosylated.

(UniProt, A1Z6H7)
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Gp210 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.44

Transcript Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 12 -- 13
organism
(Harel et al., 1989)
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
• membrane
(Aradska et al., 2015)
Additional Descriptive Data

Gp210 protein is a putative nuclear pore complex component. In early embryos, Gp210 protein localizes to the nuclear envelope during interphase, but from prophase onwards, is found throughout the cytoplasm.

(Harel et al., 1989)
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in cytoplasm
inferred from direct assay
(Harel et al., 1989)
part_of nuclear pore inner ring
inferred from direct assay
(Sabri et al., 2007)
part_of nuclear pore nuclear basket
inferred from direct assay
(Sabri et al., 2007)
part_of nuclear pore
inferred from direct assay
(Harel et al., 1989)
inferred from direct assay
(Filson et al., 1985)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Gp210 in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 9 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 5 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Gp210
Transgenic constructs containing regulatory region of Gp210
Aberrations (Deficiencies and Duplications) ( 0 )
Inferred from experimentation ( 0 )
Inferred from location ( 4 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal
viable
Sterility
Allele
fertile
Other Phenotypes
Allele
abnormal memory
Phenotype manifest in
Allele
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (2)
Hsap\NUP210
13 of 14
Yes
Yes
1  
Hsap\NUP210L
12 of 14
No
Yes
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (2)
Rnor\Nup210
13 of 14
Yes
Yes
Rnor\Nup210l
11 of 14
No
Yes
Mus musculus (laboratory mouse) (2)
Mmus\Nup210
13 of 14
Yes
Yes
Mmus\Nup210l
12 of 14
No
Yes
Xenopus tropicalis (Western clawed frog) (1)
Xtro\nup210
2 of 13
Yes
Yes
Danio rerio (Zebrafish) (1)
Drer\nup210
13 of 14
Yes
Yes
Caenorhabditis elegans (Nematode, roundworm) (1)
Cele\npp-12
13 of 14
Yes
Yes
Anopheles gambiae (African malaria mosquito) (1)
Agam\AgaP_AGAP006280
12 of 12
Yes
Yes
Arabidopsis thaliana (thale-cress) (2)
Atha\EMB3012
10 of 13
Yes
Yes
Atha\AT5G10590
1 of 13
No
Yes
Saccharomyces cerevisiae (Brewer's yeast) (0)
Schizosaccharomyces pombe (Fission yeast) (0)
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:Gp210. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    NUP210; nucleoporin 210
    13 of 14
    607703
         
        NUP210L; nucleoporin 210 like
        12 of 14
        621033
          Functional Complementation Data
          Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
          Interactions
          Summary of Physical Interactions
          esyN Network Diagram
          Show neighbor-neighbor interactions:
          Show/hide secondary interactors 
          (data from AllianceMine provided by esyN)
          Select Layout:
          Legend:
          Protein
          RNA
          Selected Interactor(s)
          Other Interaction Browsers
          View in FlyBase Interactions Browser   View in MIST tool (external link)
          Please see the Physical Interaction reports below for full details
          protein-protein
          Physical Interaction
          Assay
          References
          Gp210 - CCT3
          experimental knowledge based
          (Guruharsha et al., 2011)
          Gp210 - CCT8
          experimental knowledge based
          (Guruharsha et al., 2011)
          Gp210 - CG1092
          experimental knowledge based
          (Guruharsha et al., 2011)
          Gp210 - CG1371
          experimental knowledge based
          (Guruharsha et al., 2011)
          Gp210 - CG3008
          experimental knowledge based
          (Guruharsha et al., 2011)
          Gp210 - CG33303
          experimental knowledge based
          (Guruharsha et al., 2011)
          Gp210 - Cdc50
          experimental knowledge based
          (Guruharsha et al., 2011)
          Gp210 - Chc
          experimental knowledge based
          (Guruharsha et al., 2011)
          Gp210 - Cnx99A
          experimental knowledge based
          (Guruharsha et al., 2011)
          Gp210 - GCS2β
          experimental knowledge based
          (Guruharsha et al., 2011)
          Gp210 - Glt
          experimental knowledge based
          (Guruharsha et al., 2011)
          Gp210 - Gp93
          experimental knowledge based
          (Guruharsha et al., 2011)
          Gp210 - Idh3a
          experimental knowledge based
          (Guruharsha et al., 2011)
          Gp210 - LRP1
          experimental knowledge based
          (Guruharsha et al., 2011)
          Gp210 - LanA
          experimental knowledge based
          (Guruharsha et al., 2011)
          Gp210 - LanB1
          experimental knowledge based
          (Guruharsha et al., 2011)
          Gp210 - LanB2
          experimental knowledge based
          (Guruharsha et al., 2011)
          Gp210 - MRP
          experimental knowledge based
          (Guruharsha et al., 2011)
          Gp210 - OstΔ
          experimental knowledge based
          (Guruharsha et al., 2011)
          Gp210 - P58IPK
          experimental knowledge based
          (Guruharsha et al., 2011)
          Gp210 - Pi3K68D
          experimental knowledge based
          (Guruharsha et al., 2011)
          Gp210 - Pih1D1
          experimental knowledge based
          (Guruharsha et al., 2011)
          Gp210 - Rdh1
          experimental knowledge based
          (Guruharsha et al., 2011)
          Gp210 - RpLP0
          experimental knowledge based
          (Guruharsha et al., 2011)
          Gp210 - RpS10b
          experimental knowledge based
          (Guruharsha et al., 2011)
          Gp210 - SERCA
          experimental knowledge based
          (Guruharsha et al., 2011)
          Gp210 - ScsβG
          experimental knowledge based
          (Guruharsha et al., 2011)
          Gp210 - UQCR-C2
          experimental knowledge based
          (Guruharsha et al., 2011)
          Gp210 - boca
          experimental knowledge based
          (Guruharsha et al., 2011)
          Gp210 - bor
          experimental knowledge based
          (Guruharsha et al., 2011)
          Gp210 - cnn
          anti bait coimmunoprecipitation, peptide massfingerprinting
          (Habermann et al., 2012)
          Gp210 - wal
          experimental knowledge based
          (Guruharsha et al., 2011)
          Gp210 - α-Spec
          experimental knowledge based
          (Guruharsha et al., 2011)
          Summary of Genetic Interactions
          esyN Network Diagram
          Other Interaction Browsers
          Starting gene(s)
          Interaction type
          Interacting gene(s)
          Reference
          Starting gene(s)
          Interaction type
          Interacting gene(s)
          Reference
          External Data
          Linkouts
          DroID - A comprehensive database of gene and protein interactions.
          MIST (protein-protein) - An integrated Molecular Interaction Database
          Pathways
          Class of Gene
          Genomic Location and Detailed Mapping Data
          Chromosome (arm)
          2R
          Recombination map
          2-55
          Cytogenetic map
          41F9-41F10
          Sequence location
          FlyBase Computed Cytological Location
          Cytogenetic map
          Evidence for location
          41F9-41F10
          Limits computationally determined from genome sequence between P{PZ}l(2)0985109851&P{lacW}Src42Ak10108 and P{lacW}l(2)k09848k09848&P{EP}EP407
          Experimentally Determined Cytological Location
          Cytogenetic map
          Notes
          References
          41F-41F
          (Cohen, 2000.11.20)
          Experimentally Determined Recombination Data
          Location

          2-55

          (FlyBase, 2016)

          2-55.7

          (Comeron et al., 2012)
          Left of (cM)
          Right of (cM)
          Notes
          Stocks and Reagents
          Stocks (10)
          Genomic Clones (18)
           

          Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

          cDNA Clones (106)
           

          Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

          cDNA clones, fully sequenced
          BDGP DGC clones
          Other clones
            Drosophila Genomics Resource Center cDNA clones

            For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

            cDNA Clones, End Sequenced (ESTs)
            BDGP DGC clones
            Other clones
            RNAi and Array Information
            Linkouts
            Antibody Information
            Laboratory Generated Antibodies
             
            Commercially Available Antibodies
             
            Developmental Studies Hybridoma Bank - Monoclonal antibodies for use in research
            Cell Line Information
            Publicly Available Cell Lines
             
              Other Stable Cell Lines
               
                Other Comments

                Similar to its putative mammalian homolog the Gp188 protein is located to nuclear pore complexes, as shown by both immunofluorescence and immunoelectron microscopy. The Gp188 protein is abundant in a non-nuclear form during early embryogenesis. Isolation and characterisation of Gp188.

                (Berrios et al., 1995)

                Gp188, a putative nuclear pore complex component, is completely redistributed in the surrounding cytoplasm during prophase in early Drosophila embryos, and is present in the envelope only in interphase.

                (Harel et al., 1989)

                Gp188 protein is specifically recognised by the monoclonal antibodies AGP-26 and AGP-78.

                (Filson et al., 1985)

                Gp188 protein has been purified and its subcellular localisation has been determined.

                (Filson et al., 1985)

                Annotations CG7897, CG14467 merged as CG7897 in release 3 of the genome annotation, April 2002.

                Relationship to Other Genes
                Source for database merge of

                Source for merge of: Gp210 Gp188

                (FlyBase, 1992-)
                Additional comments

                snoRNA:gp210-a is encoded in an intron of gp210.

                (Graveley et al., 2011)

                Source for identity of gp210 CG7897 was sequence comparison ( date:010102 ).

                (FlyBase, 1996-)
                Nomenclature History
                Source for database identify of

                Source for identity of: gp210 CG7897

                (FlyBase, 1996-)

                Source for identity of: Gp210 gp210

                (FlyBase, 2009-)
                Nomenclature comments
                Etymology

                Named "Gp210" after the human ortholog.

                (FlyBase, 2009-)
                Synonyms and Secondary IDs (13)
                Datasets (0)
                Study focus (0)
                Experimental Role
                Project
                Project Type
                Title
                Study result (0)
                Result
                Result Type
                Title
                External Crossreferences and Linkouts ( 50 )
                Sequence Crossreferences
                NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
                UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
                Other crossreferences
                AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
                DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
                EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
                FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
                InterPro - A database of protein families, domains and functional sites
                KEGG Genes - Molecular building blocks of life in the genomic space.
                MARRVEL_MODEL - MARRVEL (model organism gene)
                Linkouts
                Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                DroID - A comprehensive database of gene and protein interactions.
                Developmental Studies Hybridoma Bank - Monoclonal antibodies for use in research
                Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
                iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
                MIST (protein-protein) - An integrated Molecular Interaction Database
                Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                References (71)