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FB2025_05
,
released December 11, 2025
tena, cbd, Teneurin, Dmtena, tenA
transmembrane partner of Tenascin major acting in synapse assembly at the neuromuscular junction - synaptic partner matching in olfactory system - regulates fusion of central complex primordia and eye patterning
Please see the JBrowse view of Dmel\Ten-a for information on other features
To submit a correction to a gene model please use the Contact FlyBase form
AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.56
Gene model reviewed during 5.55
Gene model reviewed during 5.42
Gene model reviewed during 5.46
Gene model reviewed during 5.49
Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated
Low-frequency RNA-Seq exon junction(s) not annotated.
Shares 5' exon(s) with upstream non-coding gene; shared promoter (one isoform only of this gene).
Homodimer. Heterodimer with Ten-m; the interaction occurs at the neuromuscular junction.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Ten-a using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
Comment: expression more pronounced in posterior commissure
Comment: 12h-48h APF
JBrowse - Visual display of RNA-Seq signals
View Dmel\Ten-a in JBrowsePlease Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
polyclonal
Ten-a instructs synaptic partner matching of projection neuron dendrites to the appropriate olfactory receptor neuron axon through homophilic attraction.
A recently produced deletion of Ten-a that removes the entire gene does not lead to lethality. The lethality and pair-rule roles reported for Ten-a mutants in FBrf0204395 therefore cannot be attributed to Ten-a, but to second site mutations.
RNAi generated by PCR using primers directed to this gene causes a cell growth and viability phenotype when assayed in Kc167 and S2R+ cells.
dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
Variation of a microsatellite within the Ten-a locus has been studied in North American populations of D.melanogaster.
Mutations causing structural defects in the adult central complex also alter larval behavioural phenotypes.
Ten-a has been cloned and characterised.
Behavioural and anatomical studies demonstrate that central brain lesions can be interpreted behaviourally.
Some alleles show abnormal position and internal structure of optic lobes.
Source for merge of: Ten-a CG12720 CG15733
Source for merge of: Ten-a CG2590 CG18182
Source for merge of: Ten-a CG15733 CG12720
Source for merge of: Ten-a cbd
Annotations CG32659, CG12720 and CG15733 merged as CG42338 in release 5.9 of the genome annotation.
Annotations CG11270, CG2590, CG18182 and CG2578 merged as CG32659 in release 3 of the genome annotation.
FlyBase curator comment: Although 'cbd' has precedence over 'Ten-a' as the symbol first used for this gene, 'Ten-a' has been retained as the FlyBase symbol (following the merge of two Gene Reports) owing to the larger body of literature using 'Ten-a', and with the agreement of authors L. Liu and M. Heisenberg.
