FlyBase Gene Report: Zzzz\GGGGCC

(Lee et al., 2024, Jhan et al., 2021, Jiao et al., 2021, Maor-Nof et al., 2021, Zaepfel et al., 2021, Cunningham et al., 2020, Han et al., 2020, Kankel et al., 2020, Lee et al., 2020, Ortega et al., 2020, Ramesh et al., 2020, Wen et al., 2020, He et al., 2019, Zhang et al., 2015)

model of amyotrophic lateral sclerosis

CEA

(Xu et al., 2013)

model of frontotemporal dementia

CEA

(Xu et al., 2013)

model of neurodegenerative disease

CEA

(Celona et al., 2017)

Zzzz\GGGGCC^3.UAS

DOES NOT model amyotrophic lateral sclerosis

CEA

(Hautbergue et al., 2017, Mizielinska et al., 2014)

DOES NOT model frontotemporal dementia

CEA

(Mizielinska et al., 2014)

Zzzz\GGGGCC^103.UAS

model of amyotrophic lateral sclerosis

CEA

(Mizielinska et al., 2014)

model of frontotemporal dementia

CEA

(Mizielinska et al., 2014)

Zzzz\GGGGCC^58.UAS.EGFP

model of amyotrophic lateral sclerosis

CEA

(Freibaum et al., 2015)

model of frontotemporal dementia

CEA

(Freibaum et al., 2015)

model of frontotemporal dementia and/or amyotrophic lateral sclerosis 1

CEC

(Cheng et al., 2019)

CEA

(Bennett et al., 2023, Ramesh et al., 2020)

Zzzz\GGGGCC^48.UAS

model of neurodegenerative disease

CEA

(Schweizer Burguete et al., 2015)

Zzzz\GGGGCC^{32.UAS.DsRed2}

model of frontotemporal dementia and/or amyotrophic lateral sclerosis 1

CEA

(Solomon et al., 2018)

Zzzz\GGGGCC^{64.UAS.DsRed2}

model of frontotemporal dementia and/or amyotrophic lateral sclerosis 1

CEA

(Solomon et al., 2018)

Zzzz\GGGGCC^{38.UAS.DsRed2}

model of frontotemporal dementia and/or amyotrophic lateral sclerosis 1

CEA

(Solomon et al., 2018)

Zzzz\GGGGCC^{44.LDS.UAS.GR-GFP}

model of frontotemporal dementia and/or amyotrophic lateral sclerosis 1

CEA

(Gotoh et al., 2024, Lee et al., 2024, Fujino et al., 2023, Cunningham et al., 2020)

CEC

(Goodman et al., 2019)

Zzzz\GGGGCC^29.UAS

model of frontotemporal dementia and/or amyotrophic lateral sclerosis 1

CEA

(Kramer et al., 2016)

Zzzz\GGGGCC^49.UAS

model of frontotemporal dementia and/or amyotrophic lateral sclerosis 1

CEA

(Goodman et al., 2019, Mordes et al., 2018, Kramer et al., 2016)

Zzzz\GGGGCC^{GFP-iC242.UAS}

model of frontotemporal dementia and/or amyotrophic lateral sclerosis 1

CEA

(He et al., 2020)

Zzzz\GGGGCC^{0+G4C2.UAS.EGFP}

model of frontotemporal dementia and/or amyotrophic lateral sclerosis 1

CEA

(He et al., 2020)

Zzzz\GGGGCC^{1+G4C2.UAS.EGFP}

model of frontotemporal dementia and/or amyotrophic lateral sclerosis 1

CEA

(He et al., 2020)

Zzzz\GGGGCC^{2+G4C2.UAS.EGFP}

model of frontotemporal dementia and/or amyotrophic lateral sclerosis 1

CEA

(He et al., 2020)

Zzzz\GGGGCC^69.CT.UAS

model of frontotemporal dementia and/or amyotrophic lateral sclerosis 1

CEA

(He et al., 2020)

Zzzz\GGGGCC^69.ΔCT.UAS

model of frontotemporal dementia and/or amyotrophic lateral sclerosis 1

CEA

(He et al., 2020)

Zzzz\GGGGCC^{1+G4C2x28.UAS.EGFP}

model of neurodegenerative disease

CEA

(Green et al., 2022)

Zzzz\GGGGCC^42.UAS

model of frontotemporal dementia and/or amyotrophic lateral sclerosis 1

CEA

(Fujino et al., 2023)

Zzzz\GGGGCC^89.UAS

model of frontotemporal dementia and/or amyotrophic lateral sclerosis 1

CEA

(Fujino et al., 2023, Taminato et al., 2023)

Zzzz\GGGGCC^107.AS.UAS

DOES NOT model frontotemporal dementia and/or amyotrophic lateral sclerosis 1

CEA

(Moens et al., 2018)

Zzzz\GGGGCC^EGFP.i-106RO

DOES NOT model frontotemporal dementia and/or amyotrophic lateral sclerosis 1

CEA

(Moens et al., 2018)

Zzzz\GGGGCC^{EGFP.i-108RO.AS}

DOES NOT model frontotemporal dementia and/or amyotrophic lateral sclerosis 1

CEA

(Moens et al., 2018)

Zzzz\GGGGCC^800RO.UAS

DOES NOT model frontotemporal dementia and/or amyotrophic lateral sclerosis 1

CEA

(Moens et al., 2018)

Zzzz\GGGGCC^1000RO.UAS

DOES NOT model frontotemporal dementia and/or amyotrophic lateral sclerosis 1

CEA

(Moens et al., 2018)

Zzzz\GGGGCC^{2000-5000RO.UAS}

DOES NOT model frontotemporal dementia and/or amyotrophic lateral sclerosis 1

CEA

(Moens et al., 2018)

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 11 )

Allele

Disease

Interaction

References

Zzzz\GGGGCC^30.UAS.EGFP

model of frontotemporal dementia and/or amyotrophic lateral sclerosis 1

is ameliorated by AstC-R1^JF02656

(Pun et al., 2022)

is ameliorated by ERR^JF02431

(Pun et al., 2022)

is ameliorated by Eip78C^JF02258

(Pun et al., 2022)

is ameliorated by Octα2R^HMC03079

(Pun et al., 2022)

is ameliorated by Pp2B-14D^JF01949

(Pun et al., 2022)

is ameliorated by Ptp69D^JF03399

(Pun et al., 2022)

is ameliorated by Shab^JF01823

(Pun et al., 2022)

is ameliorated by p53^GL01032

(Maor-Nof et al., 2021)

is ameliorated by p53^GL01220

(Maor-Nof et al., 2021)

is ameliorated by p53^HMS02286

(Maor-Nof et al., 2021)

is exacerbated by eRF1^GD4704

(Ortega et al., 2020)

is exacerbated by Art1^KK101196

(Ortega et al., 2020)

is exacerbated by Tnpo-SR^GD9833

(Ortega et al., 2020)

is exacerbated by e(y)2^KK102036

(Ortega et al., 2020)

is ameliorated by Hsap\SIGMAR1^UAS.cCa

(Lee et al., 2020)

is ameliorated by Gle1^HMC03626

(Kankel et al., 2020)

is exacerbated by Hsap\MAPT^UAS.cWa

(Wen et al., 2020)

is ameliorated by tau^KO

(Wen et al., 2020)

is ameliorated by Atg18a^HMS01193

(Cunningham et al., 2020)

is exacerbated by Atg18b^HMS01194

(Cunningham et al., 2020)

is exacerbated by Atg2^HMS01198

(Cunningham et al., 2020)

is exacerbated by Atg2^JF02786

(Cunningham et al., 2020)

is exacerbated by Atg3^EY08396

(Cunningham et al., 2020)

is exacerbated by Atg3^HMS01348

(Cunningham et al., 2020)

is exacerbated by Atg4b^P0997

(Cunningham et al., 2020)

is ameliorated by Atg5^JF02703

(Cunningham et al., 2020)

is ameliorated by Atg6^HMS01483

(Cunningham et al., 2020)

is ameliorated by Atg6^JF02897

(Cunningham et al., 2020)

is ameliorated by Atg7^HMS01358

(Cunningham et al., 2020)

is ameliorated by Atg8a^HMS01328

(Cunningham et al., 2020)

is ameliorated by Atg8a^JF02895

(Cunningham et al., 2020)

is exacerbated by Mitf^HMS02712

(Cunningham et al., 2020)

is ameliorated by Mitf^SI1-RES

(Cunningham et al., 2020)

is ameliorated by Rab7^UASp.YFP

(Cunningham et al., 2020)

is exacerbated by RanGAP^JF03244

(Cunningham et al., 2020, Zhang et al., 2015)

is exacerbated by Snap29^B6-21

(Cunningham et al., 2020)

is ameliorated by Trpml^UAS.Tag:MYC

(Cunningham et al., 2020)

is exacerbated by bchs^UAS.Tag:HA

(Cunningham et al., 2020)

is ameliorated by emb^JF01311

(Cunningham et al., 2020)

is ameliorated by ref(2)P^HMS00551

(Cunningham et al., 2020)

is exacerbated by ref(2)P^UAS.Tag:HA

(Cunningham et al., 2020)

is ameliorated by Atg1^UAS.cSa

(Cunningham et al., 2020)

is ameliorated by Atg101^HMS01349

(Cunningham et al., 2020)

is exacerbated by Atg13^HMS02028

(Cunningham et al., 2020)

is ameliorated by Atg14^HMC04086

(Cunningham et al., 2020)

is exacerbated by Atg14^HMS02025

(Cunningham et al., 2020)

is exacerbated by Atg16^HMJ22265

(Cunningham et al., 2020)

is exacerbated by Atg16^HMS01347

(Cunningham et al., 2020)

is exacerbated by Atg17^HMS01611

(Cunningham et al., 2020)

is exacerbated by Mhc^KK102402

(Kim et al., 2019)

is exacerbated by Mhc^HMS01471

(Kim et al., 2019)

is exacerbated by Mhc^JF02069

(Kim et al., 2019)

is ameliorated by RanGAP^Sd

(Zhang et al., 2015)

is ameliorated by RanGAP^UAS.Tag:HA

(Zhang et al., 2015)

is ameliorated by CG8173^JF01161

(Jiao et al., 2021)

is ameliorated by Myb^JF02135

(Jiao et al., 2021)

is ameliorated by Top2^GL00338

(Jiao et al., 2021)

is ameliorated by Top2^JF01300

(Jiao et al., 2021)

is ameliorated by Hsap\MATR3^{ΔRRM1.UAS.Tag:FLAG}

(Ramesh et al., 2020)

is ameliorated by Hsap\MATR3^{ΔZNF1.UAS.Tag:FLAG}

(Ramesh et al., 2020)

is ameliorated by Hsap\MATR3^{ΔZNF2.UAS.Tag:FLAG}

(Ramesh et al., 2020)

is ameliorated by Hsap\MATR3^UAS.Tag:FLAG

(Ramesh et al., 2020)

is exacerbated by Upf1^GL01485

(Zaepfel et al., 2021)

is exacerbated by Upf1^HMC05537

(Zaepfel et al., 2021)

is ameliorated by Upf1^UASp.GFP

(Zaepfel et al., 2021)

is ameliorated by Rel^GD1199

(Han et al., 2020)

is ameliorated by tup^HMC03317

(Han et al., 2020)

is exacerbated by Rhau^UAS.Tag:HA

(Lee et al., 2024)

model of amyotrophic lateral sclerosis

is ameliorated by Pur-α^UAS.Tag:FLAG

(Xu et al., 2013)

model of frontotemporal dementia

is ameliorated by Pur-α^UAS.Tag:FLAG

(Xu et al., 2013)

model of neurodegenerative disease

is ameliorated by Mmus\Zfp106^{UAS.Tag:FLAG,Tag:StrepII}

(Celona et al., 2017)

exacerbates tauopathy

modeled by Hsap\MAPT^UAS.cWa

(He et al., 2019)

modeled by Hsap\MAPT^R406W.UAS

(He et al., 2019)

model of frontotemporal dementia and/or amyotrophic lateral sclerosis 2

is ameliorated by HDAC6^JF01501

(Kankel et al., 2020)

model of frontotemporal dementia and/or amyotrophic lateral sclerosis 4

is ameliorated by Hsp110^d03562

(Kankel et al., 2020)

is ameliorated by Rala^HMS01365

(Kankel et al., 2020)

is ameliorated by Rala^S25N.UAS

(Kankel et al., 2020)

model of frontotemporal dementia and/or amyotrophic lateral sclerosis 3

is ameliorated by futsch^EP1419

(Kankel et al., 2020)

Zzzz\GGGGCC^36.UAS

model of amyotrophic lateral sclerosis

is ameliorated by SF2^GD12097

(Hautbergue et al., 2017)

is NOT ameliorated by Ref1^KK109076

(Hautbergue et al., 2017)

is NOT ameliorated by Ref1^GD4683

(Hautbergue et al., 2017)

model of frontotemporal dementia and/or amyotrophic lateral sclerosis 1

is exacerbated by e(y)2^KK102036

(Ortega et al., 2020)

is exacerbated by eRF1^GD4704

(Ortega et al., 2020)

is exacerbated by Art1^KK101196

(Ortega et al., 2020)

is exacerbated by CCT8^KK100186

(Ortega et al., 2020)

is ameliorated by SF2^GD12097

(Castelli et al., 2021, Ortega et al., 2020)

is exacerbated by Tnpo-SR^GD9833

(Ortega et al., 2020)

is ameliorated by ref(2)P^HMS00551

(Cunningham et al., 2020)

is ameliorated by ref(2)P^HMS00938

(Cunningham et al., 2020)

is exacerbated by ref(2)P^UAS.Tag:HA

(Cunningham et al., 2020)

is ameliorated by eIF1A^UAS.ORF

(Moens et al., 2019)

is ameliorated by Akt^{T342D.S505D.GMR}

(Atilano et al., 2021)

is exacerbated by InR^K1409A.UAS

(Atilano et al., 2021)

is ameliorated by SK^MI09020

(Castelli et al., 2021)

is ameliorated by SK^MI10378

(Castelli et al., 2021)

is ameliorated by Hsap\MATR3^UAS.Tag:FLAG

(Ramesh et al., 2020)

is ameliorated by Pka-C1^KK108966

(Licata et al., 2022)

is ameliorated by Pka-C1^VSH330111

(Licata et al., 2022)

is exacerbated by LanB1^EP-600

(Catterson et al., 2023)

is exacerbated by chk^{UAS.ORF.GW.Tag:HA}

(Xu et al., 2023)

is ameliorated by bumpel^{UAS.ORF.GW.Tag:HA}

(Xu et al., 2023)

Zzzz\GGGGCC^58.UAS.EGFP

model of amyotrophic lateral sclerosis

is exacerbated by Nup50^GD9739

(Freibaum et al., 2015)

is exacerbated by Nup50^KG09557

(Freibaum et al., 2015)

is exacerbated by Nup50^KK108150

(Freibaum et al., 2015)

is exacerbated by Ran^{T24N.UASp.Tag:HA}

(Freibaum et al., 2015)

is exacerbated by Nup153^GD10636

(Freibaum et al., 2015)

is exacerbated by Nup153^KK110135

(Freibaum et al., 2015)

is exacerbated by CG9775^KK110941

(Freibaum et al., 2015)

is exacerbated by Tnpo^KK108990

(Freibaum et al., 2015)

is ameliorated by Ref1⁰²²⁶⁷

(Freibaum et al., 2015)

is exacerbated by Gle1^JF01431

(Freibaum et al., 2015)

is exacerbated by sbr^GD14541

(Freibaum et al., 2015)

is exacerbated by Cbp20^KK109448

(Freibaum et al., 2015)

is exacerbated by sbr^KK100882

(Freibaum et al., 2015)

is exacerbated by Cbp80^KK100796

(Freibaum et al., 2015)

is exacerbated by sbr^HM05135

(Freibaum et al., 2015)

is exacerbated by Cbp80^GD12110

(Freibaum et al., 2015)

is exacerbated by Ars2^KK109705

(Freibaum et al., 2015)

is exacerbated by Ars2^HMS00626

(Freibaum et al., 2015)

is exacerbated by Ars2^GL00079

(Freibaum et al., 2015)

is exacerbated by Rrp6^KK100590

(Freibaum et al., 2015)

is exacerbated by Rrp40^GD10414

(Freibaum et al., 2015)

is ameliorated by Nup98-96^KK100388

(Freibaum et al., 2015)

is ameliorated by Nup98-96^GD6897

(Freibaum et al., 2015)

is ameliorated by Nup107^KK108047

(Freibaum et al., 2015)

is ameliorated by Nup107^GD12024

(Freibaum et al., 2015)

is ameliorated by Nup160^KK104805

(Freibaum et al., 2015)

is exacerbated by emb^JF01311

(Freibaum et al., 2015)

is exacerbated by LBR^HMC02426

(Freibaum et al., 2015)

model of frontotemporal dementia

is exacerbated by Nup50^GD9739

(Freibaum et al., 2015)

is exacerbated by Nup50^KG09557

(Freibaum et al., 2015)

is exacerbated by Nup50^KK108150

(Freibaum et al., 2015)

is exacerbated by Ran^{T24N.UASp.Tag:HA}

(Freibaum et al., 2015)

is exacerbated by Nup153^GD10636

(Freibaum et al., 2015)

is exacerbated by LBR^HMC02426

(Freibaum et al., 2015)

is exacerbated by Nup153^KK110135

(Freibaum et al., 2015)

is exacerbated by Tnpo^KK108990

(Freibaum et al., 2015)

is ameliorated by Ref1⁰²²⁶⁷

(Freibaum et al., 2015)

is exacerbated by Gle1^JF01431

(Freibaum et al., 2015)

is exacerbated by CG9775^KK110941

(Freibaum et al., 2015)

is exacerbated by Cbp20^KK109448

(Freibaum et al., 2015)

is exacerbated by sbr^GD14541

(Freibaum et al., 2015)

is exacerbated by Cbp80^KK100796

(Freibaum et al., 2015)

is exacerbated by sbr^KK100882

(Freibaum et al., 2015)

is exacerbated by Cbp80^GD12110

(Freibaum et al., 2015)

is exacerbated by Ars2^KK109705

(Freibaum et al., 2015)

is exacerbated by Ars2^HMS00626

(Freibaum et al., 2015)

is exacerbated by Ars2^GL00079

(Freibaum et al., 2015)

is exacerbated by Rrp6^KK100590

(Freibaum et al., 2015)

is exacerbated by sbr^HM05135

(Freibaum et al., 2015)

is exacerbated by Rrp40^GD10414

(Freibaum et al., 2015)

is ameliorated by Nup98-96^KK100388

(Freibaum et al., 2015)

is ameliorated by Nup98-96^GD6897

(Freibaum et al., 2015)

is ameliorated by Nup107^KK108047

(Freibaum et al., 2015)

is ameliorated by Nup107^GD12024

(Freibaum et al., 2015)

is ameliorated by Nup160^KK104805

(Freibaum et al., 2015)

is exacerbated by emb^JF01311

(Freibaum et al., 2015)

model of frontotemporal dementia and/or amyotrophic lateral sclerosis 1

is exacerbated by bel^EY08943

(Cheng et al., 2019)

is exacerbated by bel^GL00205

(Cheng et al., 2019)

is exacerbated by bel^JF02884

(Cheng et al., 2019)

is ameliorated by Hsap\MATR3^UAS.Tag:FLAG

(Ramesh et al., 2020)

is ameliorated by Hsap\SETX^{L389S.UAS.Tag:FLAG}

(Bennett et al., 2023)

is ameliorated by Hsap\SETX^UAS.Tag:FLAG

(Bennett et al., 2023)

Zzzz\GGGGCC^48.UAS

model of neurodegenerative disease

is ameliorated by Fmr1^HMS00248

(Schweizer Burguete et al., 2015)

is exacerbated by Fmr1^UAS.cWa

(Schweizer Burguete et al., 2015)

is ameliorated by orb2^JF02376

(Schweizer Burguete et al., 2015)

is exacerbated by orb2^UAS.cUa

(Schweizer Burguete et al., 2015)

Zzzz\GGGGCC^{38.UAS.DsRed2}

model of frontotemporal dementia and/or amyotrophic lateral sclerosis 1

is exacerbated by TBPH^ΔNLS

(Solomon et al., 2018)

Zzzz\GGGGCC^{44.LDS.UAS.GR-GFP}

model of frontotemporal dementia and/or amyotrophic lateral sclerosis 1

is ameliorated by eIF5^HMS00159

(Gotoh et al., 2024)

is ameliorated by eIF5^KK102299

(Gotoh et al., 2024)

is ameliorated by ref(2)P^HMS00551

(Cunningham et al., 2020)

is exacerbated by ref(2)P^UAS.Tag:HA

(Cunningham et al., 2020)

is ameliorated by eIF4B^HMS04503

(Goodman et al., 2019)

is ameliorated by eIF4B^VSH330010

(Goodman et al., 2019)

is ameliorated by eIF4H1^HMS04504

(Goodman et al., 2019)

is ameliorated by eIF4H1^KK108805

(Goodman et al., 2019)

Zzzz\GGGGCC^29.UAS

model of frontotemporal dementia and/or amyotrophic lateral sclerosis 1

is ameliorated by spt4^HMS00685

(Kramer et al., 2016)

Zzzz\GGGGCC^49.UAS

model of frontotemporal dementia and/or amyotrophic lateral sclerosis 1

is ameliorated by Atu^GD8296

(Goodman et al., 2019)

is ameliorated by Atu^KK104959

(Goodman et al., 2019)

is ameliorated by atms^GD9782

(Goodman et al., 2019)

is ameliorated by atms^KK100080

(Goodman et al., 2019)

is ameliorated by hyx^GD12640

(Goodman et al., 2019)

is ameliorated by Ctr9^HMS00619

(Goodman et al., 2019)

is ameliorated by Ctr9^KK101412

(Goodman et al., 2019)

is ameliorated by Rtf1^HMS00168

(Goodman et al., 2019)

is ameliorated by hyx^HMC03494

(Goodman et al., 2019)

is ameliorated by Rtf1^KK101209

(Goodman et al., 2019)

is ameliorated by spt4^HMS00685

(Kramer et al., 2016)

is exacerbated by Hsf^+t8

(Mordes et al., 2018)

Zzzz\GGGGCC^{1+G4C2x28.UAS.EGFP}

model of neurodegenerative disease

is ameliorated by DENR^GD17852

(Green et al., 2022)

is ameliorated by DENR^KK109336

(Green et al., 2022)

is ameliorated by eIF2A^HMC03050

(Green et al., 2022)

is ameliorated by eIF2D^HMS00958

(Green et al., 2022)

Zzzz\GGGGCC^42.UAS

model of frontotemporal dementia and/or amyotrophic lateral sclerosis 1

is ameliorated by Hsap\SF3B3^UAS.cFa

(Fujino et al., 2023)

is exacerbated by Hsap\SFPQ^UAS.cFa

(Fujino et al., 2023)

is ameliorated by Hsap\FUS^UAS.cIa

(Fujino et al., 2023)

is ameliorated by Hsap\HNRNPA1^UAS.cFa

(Fujino et al., 2023)

is ameliorated by Hsap\HNRNPA2B1^UAS.cFa

(Fujino et al., 2023)

is exacerbated by Hsap\HNRNPK^UAS.cFa

(Fujino et al., 2023)

is ameliorated by Hsap\HNRNPL^UAS.cFa

(Fujino et al., 2023)

is ameliorated by Hsap\HNRNPR^UAS.cFa

(Fujino et al., 2023)

is ameliorated by Hsap\IGF2BP1^UAS.cFa

(Fujino et al., 2023)

is ameliorated by Hsap\SAFB2^UAS.cFa

(Fujino et al., 2023)

Zzzz\GGGGCC^89.UAS

model of frontotemporal dementia and/or amyotrophic lateral sclerosis 1

is ameliorated by Hsap\SF3B3^UAS.cFa

(Fujino et al., 2023, Taminato et al., 2023)

is exacerbated by Hsap\SFPQ^UAS.cFa

(Fujino et al., 2023)

is exacerbated by caz²

(Fujino et al., 2023)

is exacerbated by caz^KK107486

(Fujino et al., 2023)

is ameliorated by Hsap\DDX17^UAS.cFa

(Fujino et al., 2023)

is ameliorated by Hsap\DDX3X^UAS.cFa

(Fujino et al., 2023)

is ameliorated by Hsap\DDX5^UAS.cFa

(Fujino et al., 2023)

is ameliorated by Hsap\DHX36^UAS.cFa

(Fujino et al., 2023)

is ameliorated by Hsap\DHX9^UAS.cFa

(Fujino et al., 2023)

is ameliorated by Hsap\EWSR1^UAS.cCa

(Fujino et al., 2023)

is ameliorated by Hsap\FUS^UAS.cIa

(Fujino et al., 2023)

is ameliorated by Hsap\HNRNPA1^UAS.cFa

(Fujino et al., 2023)

is ameliorated by Hsap\HNRNPA2B1^UAS.cFa

(Fujino et al., 2023, Taminato et al., 2023)

is exacerbated by Hsap\HNRNPK^UAS.cFa

(Fujino et al., 2023)

is ameliorated by Hsap\HNRNPL^UAS.cFa

(Fujino et al., 2023)

is ameliorated by Hsap\HNRNPR^UAS.cFa

(Fujino et al., 2023, Taminato et al., 2023)

is ameliorated by Hsap\IGF2BP1^UAS.cFa

(Fujino et al., 2023, Taminato et al., 2023)

is ameliorated by Hsap\SAFB2^UAS.cFa

(Fujino et al., 2023)

is exacerbated by Hrb87F^KK108162

(Taminato et al., 2023)

is ameliorated by Hsap\HNRNPA3^UAS.cTa

(Taminato et al., 2023)

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Other Interaction Browsers

Summary of Genetic Interactions

esyN Network Diagram

Other Interaction Browsers

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

Class of Gene

engineered_foreign_region

(FlyBase Curators, 1992-)

Stocks and Reagents

Stocks (11)

Bloomington

58687

w¹¹¹⁸; P{UAS-GGGGCC.3}attP40

58688

w¹¹¹⁸; P{UAS-GGGGCC.36}attP40

58689

w¹¹¹⁸; P{UAS-GGGGCC.36-RO}attP40

58690

w¹¹¹⁸; P{UAS-GGGGCC.108-RO}attP40

58691

w¹¹¹⁸; P{UAS-GGGGCC.288-RO}attP40

84722

P{UAS-LDS-(G4C2)12.GR-GFP}2, w¹¹¹⁸

84723

w¹¹¹⁸; P{UAS-LDS-(G4C2)44.GR-GFP}9

84727

w¹¹¹⁸; P{UAS-(GGGGCC)₄₉}48-10

84725

w¹¹¹⁸; P{UAS-(GGGGCC)₂₉}48-12/SM6b

84724

w¹¹¹⁸; P{UAS-(GGGGCC)₈}48-2/TM6C, Sb¹

84726

w¹¹¹⁸; P{UAS-(GGGGCC)₄₉}48-3.1/TM6C, Sb¹

Other Comments

Relationship to Other Genes

Source for database merge of

Additional comments

Nomenclature History

Source for database identify of

Nomenclature comments

Etymology

Synonyms and Secondary IDs (9)

Reported As

Symbol Synonym

(GGGGCC)n

(Moens et al., 2018)

G4C2

(Ramesh et al., 2020, Berson et al., 2019, Solomon et al., 2018, Wen et al., 2014)

G₄C₂

(Coyne et al., 2017)

GGGGCC

(Celona et al., 2017, Mizielinska et al., 2014)

Zzzz\GGGGCC

(Kramer et al., 2016)

Name Synonyms

G4C2 repeat

(NeuroLINCS Consortium et al., 2021)

G4C2 repeats

(Simone et al., 2018)

GGGGCC hexanucleotide

GGGGCC hexanucleotide repeat

(Moens et al., 2018)

Secondary FlyBase IDs

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 0 )

References (79)

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