FlyBase Gene Report: Dmel\SelR

General Information

Symbol

Dmel\SelR

Species

D. melanogaster

Name

Selenoprotein R

Annotation Symbol

CG6584

Feature Type

protein_coding_gene

FlyBase ID

FBgn0267376

Gene Model Status

Current

Stock Availability

11 publicly available

Enzyme Name (EC)

peptide-methionine (R)-S-oxide reductase (1.8.4.12)

Gene Summary

Selenoprotein R (SelR) encodes a methionine sulfoxide reductase, which specifically converts the R isomer of methionine sulfoxide back to methionine. It reverses the modification of actin performed by the product of Mical, thus restoring actin to normal function. It contributes to actin organization in neuronal and muscle tissue. [Date last reviewed: 2019-03-14] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
UniProtKB
Interactive Fly

Also Known As

MsrB, EP3340

Key Links

Genomic Location

Cytogenetic map

86C7-86C7

Sequence location

3R:10,863,355..10,868,642 [-]

Recombination map

3-50

RefSeq locus

NT_033777 REGION:10863355..10868642

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (13 terms)

Molecular Function (2 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

enables peptide-methionine (R)-S-oxide reductase activity

inferred from direct assay

(Kryukov et al., 2002, Kumar et al., 2002)

inferred from direct assay

(Hung et al., 2013)

enables zinc ion binding

inferred from direct assay

(Kumar et al., 2002)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

enables peptide-methionine (R)-S-oxide reductase activity

inferred from biological aspect of ancestor with PANTHER:PTN000019160

(GO Reference Genome Project, 2011-)

inferred from electronic annotation with InterPro:IPR002579

(InterPro Project Members, 2004-)

Biological Process (6 terms)

Terms Based on Experimental Evidence (4 terms)

CV Term

Evidence

References

involved_in actin filament organization

inferred from mutant phenotype

(Hung et al., 2013)

involved_in actin filament polymerization

inferred from genetic interaction with FLYBASE:Mical; FB:FBgn0053208

(Hung et al., 2013)

involved_in axon guidance

inferred from mutant phenotype

(Hung et al., 2013)

involved_in chaeta morphogenesis

inferred from mutant phenotype

(Hung et al., 2013)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

involved_in protein repair

inferred from sequence or structural similarity with UniProtKB:Q8IXL7

(Gene Ontology Curators, 2002-)

inferred from electronic annotation with InterPro:IPR028427

(InterPro Project Members, 2004-)

involved_in response to oxidative stress

inferred from electronic annotation with InterPro:IPR028427

(InterPro Project Members, 2004-)

Cellular Component (5 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

located_in cytosol

inferred from high throughput direct assay

(Lye et al., 2014)

located_in nucleoplasm

inferred from high throughput direct assay

(Lye et al., 2014)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

is_active_in cytoplasm

inferred from biological aspect of ancestor with PANTHER:PTN000019160

(GO Reference Genome Project, 2011-)

located_in endoplasmic reticulum

inferred from sequence or structural similarity with UniProtKB:Q8IXL7

(Gene Ontology Curators, 2002-)

located_in mitochondrion

inferred from sequence or structural similarity with UniProtKB:Q8IXL7

(Gene Ontology Curators, 2002-)

Gene Group (FlyBase)

UNCLASSIFIED SULFUR OXIDOREDUCTASES, DISULFIDE AS ACCEPTOR

Protein Family (UniProt)

Belongs to the MsrB Met sulfoxide reductase family. (Q8INK9)

Protein Signatures (InterPro)

Catalytic Activity (EC/Rhea)

peptide-methionine (R)-S-oxide reductase activity

L-methionyl-[protein] + [thioredoxin]-disulfide + H2O = L-methionyl-(R)- S-oxide-[protein] + [thioredoxin]-dithiol (1.8.4.12)

RHEA 24164:

Summaries

Gene Snapshot

Gene Group (FlyBase)

UNCLASSIFIED SULFUR OXIDOREDUCTASES, DISULFIDE AS ACCEPTOR -: This group comprises sulfur oxidoreductases using disulfide as acceptor that do not classify under other groups in FlyBase.

Protein Function (UniProtKB)

Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residues. Acts as a regulator of actin assembly by reducing methionine (R)-sulfoxide mediated by Mical on actin thereby promoting filament repolymerization.

(UniProt, Q8INK9)

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\SelR for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q8INK9)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.47

Low-frequency RNA-Seq exon junction(s) not annotated.

Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

SelR-RA

FBtr0082292

NM_141773

1008

155

SelR-RB

FBtr0082291

NM_169370

1041

166

SelR-RC

FBtr0082294

NM_169368

1123

197

SelR-RE

FBtr0082295

NM_169369

1156

208

SelR-RG

FBtr0273345

NM_001144564

2298

157

SelR-RH

FBtr0273346

NM_169371

2277

150

SelR-RI

FBtr0273347

NM_206473

992

155

SelR-RJ

FBtr0306641

NM_001260107

2392

192

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

SelR-PA

FBpp0081769

17.4

155

8.05

FBpp0081768

18.5

166

8.06

FBpp0081771

22.2

197

8.86

NP_731522

AAN13490

SelR-PE

FBpp0081772

23.3

208

8.86

FBpp0271853

17.6

157

8.87

FBpp0271854

16.8

150

8.68

NP_731525

AAN13493

SelR-PI

FBpp0271855

17.4

155

8.05

FBpp0297596

21.6

192

9.47

D3DMP0

NP_001247036

AFH06354

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

155 aa isoforms: SelR-PA, SelR-PI

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\SelR using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.96

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage

larval ventral nerve cord

(Hung et al., 2013)

larval brain

(Hung et al., 2013)

embryonic stage 1 -- 3

organism

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 4 -- 6

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 7 -- 8

organism | faint | ubiquitous

(Fisher et al., 2012)

trunk mesoderm

(Fisher et al., 2012)

embryonic stage 9 -- 10

anterior endoderm

(Fisher et al., 2012)

organism | faint | ubiquitous

(Fisher et al., 2012)

posterior endoderm

(Fisher et al., 2012)

trunk mesoderm

(Fisher et al., 2012)

embryonic stage 11 -- 12

anterior midgut primordium

(Fisher et al., 2012)

organism | faint | ubiquitous

(Fisher et al., 2012)

posterior midgut primordium

(Fisher et al., 2012)

trunk visceral muscle primordium

(Fisher et al., 2012)

embryonic stage 13 -- 16

embryonic/larval midgut

(Fisher et al., 2012)

larval visceral muscle cell

(Fisher et al., 2012)

organism | faint | ubiquitous

(Fisher et al., 2012)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

macrochaeta

(Hung et al., 2013)

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in cytosol

inferred from high throughput direct assay

(Lye et al., 2014)

located_in nucleoplasm

inferred from high throughput direct assay

(Lye et al., 2014)

Expression Deduced from Reporters

Reporter: PBac{602.P.SVS-1}SelR^CPTI001015

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult brain cell body rind

(Knowles-Barley, 2011.8.24)

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\SelR in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\SelR

View exonic expression by tissue for Dmel\SelR

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0267376

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

41309/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0267376

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0037847

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0267376

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG6584

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 8 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 11 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of SelR

Transgenic constructs containing regulatory region of SelR

Aberrations (Deficiencies and Duplications) ( 4 )

Inferred from experimentation ( 4 )

Gene disrupted in

Df(3R)Exel6159

(Ryder, 2004.4.26)

Df(3R)Exel7305

(Ryder, 2004.4.26)

Df(3R)SelR^Delta3

(Hung et al., 2013)

Df(3R)Tsp86DΔ3

(Dornier et al., 2012)

Inferred from location ( 7 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Other Phenotypes

Allele

abnormal neuroanatomy, with Scer\GAL4^elav.PU

SelR^UAS.cHa

long lived

SelR^w26

short lived

SelR^w2

Phenotype manifest in

Allele

filamentous actin | third instar larval stage, with Scer\GAL4^how-24B

SelR^UAS.cHa

filamentous actin | third instar larval stage, with Scer\GAL4^Mef2.PR

SelR^UAS.cHa

larval intersegmental nerve, with Scer\GAL4^elav-C155

SelR^EP3340

larval intersegmental nerve branch ISNb of A1-7

SelR^UAS.cHa

larval somatic muscle cell | third instar larval stage, with Scer\GAL4^how-24B

SelR^UAS.cHa

larval somatic muscle cell | third instar larval stage, with Scer\GAL4^Mef2.PR

SelR^UAS.cHa

macrochaeta, with Scer\GAL4^B11-98

SelR^C124S.UAS

macrochaeta (with Df(3R)SelR^Delta3)

synapse, with Scer\GAL4^elav.PU

SelR^UAS.cHa

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (3)

Hsap\MSRB3

14 of 14

Yes

Hsap\MSRB2

8 of 14

Yes

Hsap\MSRB1

3 of 14

Yes

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (3)

Rnor\Msrb3

14 of 14

Yes

Rnor\Msrb2

8 of 14

Yes

Rnor\Msrb1

2 of 14

Yes

Mus musculus (laboratory mouse) (3)

Mmus\Msrb3

14 of 14

Yes

Mmus\Msrb2

7 of 14

Yes

Mmus\Msrb1

3 of 14

Yes

Xenopus tropicalis (Western clawed frog) (2)

Xtro\msrb2

9 of 13

Yes

Xtro\msrb1

2 of 13

Yes

Danio rerio (Zebrafish) (4)

Drer\msrb3

14 of 14

Yes

Drer\msrb2

9 of 14

Yes

Drer\msrb1a

2 of 14

Yes

Drer\msrb1b

2 of 14

Caenorhabditis elegans (Nematode, roundworm) (1)

Cele\F44E2.6

12 of 14

Yes

Anopheles gambiae (African malaria mosquito) (1)

Agam\AgaP_AGAP013286

9 of 12

Yes

Arabidopsis thaliana (thale-cress) (9)

Atha\MSRB1

12 of 13

Yes

Atha\MSRB2

8 of 13

Yes

Atha\MSRB3

8 of 13

Yes

Atha\MSRB4

8 of 13

Yes

Atha\MSRB5

8 of 13

Yes

Atha\MSRB6

7 of 13

Yes

Atha\MSRB7

7 of 13

Yes

Atha\MSRB8

7 of 13

Yes

Atha\MSRB9

7 of 13

Yes

Saccharomyces cerevisiae (Brewer's yeast) (1)

Scer\MXR2

10 of 13

Yes

Schizosaccharomyces pombe (Fission yeast) (1)

Spom\SPBC216.04c

10 of 12

Yes

Escherichia coli (enterobacterium) (1)

Ecol\msrB

10 of 11

Yes

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:SelR. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (1)

MsrA

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 1 )

Human Ortholog

Disease

Evidence

References

MSRB3; methionine sulfoxide reductase B3

model of autosomal recessive nonsyndromic deafness 74

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 1 )

Allele

Disease

Interaction

References

SelR^MI14226

exacerbates tauopathy

modeled by Hsap\MAPT^{P301L.QUAS.0N4R}

(Praschberger et al., 2023)

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

MSRB3; methionine sulfoxide reductase B3

14 of 14

613719

DEAFNESS, AUTOSOMAL RECESSIVE 74; DFNB74

autosomal recessive nonsyndromic deafness 74

MSRB2; methionine sulfoxide reductase B2

8 of 14

613782

MSRB1; methionine sulfoxide reductase B1

3 of 14

606216

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Other Interaction Browsers

Summary of Genetic Interactions

esyN Network Diagram

Show/hide secondary interactors
(data from AllianceMine provided by esyN)

esyN Network Key:

Suppression

Enhancement

Other Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Mical|SelR

suppressible

Act5C

(Hung et al., 2013)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Mical

enhanceable

SelR

(Hung et al., 2013)

Mical

suppressible

SelR

(Hung et al., 2013)

PlexA

suppressible

SelR

(Hung et al., 2013)

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0267376

MIST (genetic) - An integrated Molecular Interaction Database

41309

MIST (protein-protein) - An integrated Molecular Interaction Database

41309

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Protein repair

Class of Gene

gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-50

Cytogenetic map

86C7-86C7

Sequence location

3R:10,863,355..10,868,642 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

86C7-86C7

Limits computationally determined from genome sequence between P{PZ}hth⁰⁵⁷⁴⁵ and P{EP}EP3340^EP3340

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

3-50

(FlyBase, 2016)

3-47.1

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (11)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

59484

y¹ w^*; Mi{MIC}SelR^MI14226

22559

y¹ w^67c23; P{EPgy2}SelR^EY22443

17116

w¹¹¹⁸; P{EP}SelR^EP3340/TM6B, Tb¹

76432

y¹ sc^* v¹ sev²¹; P{TKO.GS00603}attP40

78200

y¹ sc^* v¹ sev²¹; P{TOE.GS01377}attP40

52919

y¹ sc^* v¹ sev²¹; P{TRiP.HMC03659}attP40

Kyoto

115061

w¹¹¹⁸; PBac{602.P.SVS-1}SelR^CPTI001015

140525

y^* w^*; P{FRT(w^hs)}2A P{neoFRT}82B PBac{SAstopDsRed}SelR^LL01897 P{Car20y}96E/TM6B, Tb¹

NIG-Fly

HMJ23810

y¹ v¹; P{TRiP.HMJ23810}attP40/CyO

VDRC

v110755

P{KK108939}VIE-260B

v25999

w¹¹¹⁸; P{GD10579}v25999

Genomic Clones (23)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (383)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0267376

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Relationship to Other Genes

Source for database merge of

Source for merge of: SelR BcDNA:RE36040

(FlyBase, 1996-)

Source for merge of: SelR BcDNA:RH61230

(FlyBase, 1996-)

Source for merge of: SelR EP3340

(Hung et al., 2013)

Additional comments

Source for identity of SelR CG6584 was sequence comparison ( date:020416 ).

(FlyBase, 1996-)

Source for merge of SelR BcDNA:RE36040 was a shared cDNA ( date:030728 ).

(FlyBase, 1996-)

Source for merge of SelR BcDNA:RH61230 was a shared cDNA ( date:030728 ).

(FlyBase, 1996-)

Nomenclature History

Source for database identify of

Source for identity of: SelR CG6584

(FlyBase, 1996-)

Nomenclature comments

Etymology

Synonyms and Secondary IDs (12)

Reported As

Symbol Synonym

BcDNA:RE36040

BcDNA:RH61230

CG6584

(National Institute of Genetics Fly Stocks, 2023-, Parkhitko et al., 2016, Meadows, 2014.12.12, Ni et al., 2010.12.1, Keleman et al., 2009.8.5)

EP3340

MSRB

(Bruce et al., 2018)

MsrB

(Hung et al., 2013, Shchedrina et al., 2009, Roesijadi et al., 2007, Kim and Gladyshev, 2006, Kumar et al., 2002)

SelR

(Sutton et al., 2024, Praschberger et al., 2023, Titlow et al., 2023, Okuda et al., 2022, Pavlidaki et al., 2022, Grintsevich et al., 2021, McLaughlin et al., 2021, Bai et al., 2020, Bruce et al., 2018, Transgenic RNAi Project members, 2017-, Yuan et al., 2015, Ashwal-Fluss et al., 2014, Esslinger et al., 2013, Hung et al., 2013, Friedman et al., 2011, Roesijadi et al., 2007)

dMsrB

(Shchedrina et al., 2009)

selR

(Wagner et al., 2009, McGraw et al., 2008)

Name Synonyms

EP3340

Methionine-R-sulfoxide reductase

(Hung et al., 2013)

SelR

Selenoprotein R

methionine-R-sulfoxide reductase

(Kumar et al., 2002)

Secondary FlyBase IDs

FBgn0044460
FBgn0037847
FBgn0064792
FBgn0064887

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 65 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

41309

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q8INK9

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

Q8INK9

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

D3DMP0

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q8INK9

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0267376

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

41309/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0267376

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0267376

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG6584

MARRVEL_MODEL - MARRVEL (model organism gene)

41309

Linkouts

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0267376

DroID - A comprehensive database of gene and protein interactions.

FBgn0267376

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0037847

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0267376

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG6584

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0267376

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC010923

MIST (genetic) - An integrated Molecular Interaction Database

41309

MIST (protein-protein) - An integrated Molecular Interaction Database

41309

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Protein repair

References (52)

The following external sites may use different assemblies or annotations than FlyBase.

-0.96

Report Sections