crl, courtless
Please see the JBrowse view of Dmel\Ubc7 for information on other features
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AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.50
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.44
1.3 (northern blot)
200, 185 (aa); 22, 20 (kD predicted)
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Ubc7 using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
Comment: maternally deposited
In situ analysis was performed with a probe that can detect all 3 classes of cDNAs identified in the study. Early expression is detected in the yolk as well as in the peripheral blastoderm cells.
Ubc7 transcripts are detected throughout development. 1.3 and 1.1 kb transcripts are detected at equal amounts during embryogenesis. Expression declines in larvae but increases in pupal and adult stages. 1.3 and 1.1 kb transcripts are detected in males and females, with higher levels in males, but the transcripts which retain the fourth intron are male-specific.
This transcript is not male-specific.
JBrowse - Visual display of RNA-Seq signals
View Dmel\Ubc7 in JBrowse1-54
1-55.5
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for merge of: crl Ubc47D
Orgad et al., 2000 (FBrf0128599) describes a male-sterile mutation called 'courtless' ('col' or 'crl') associated with a "ms(2)P[ry+]4" insertion on the second chromosome in cytological band 47D, generated by mobilization of the P{Car20} vector. The gene is cloned as a homolog of yeast ubiquitin conjugating enzyme UBC7, and the published sequence matches the CG4442 annotation. The problem is that CG4442 is on the X chromosome at 14F, meaning the data in FBrf0128599 are conflicting. The most parsimonious explanation is that the original mutant strain harbored two separate insertions: one insertion at 47D (2nd chromosome) that causes male sterility and whose molecular identity is unknown; and a second insertion at 14F (X chromosome) that disrupts the CG4442 gene, encoding a ubiquitin conjugating enzyme. Therefore, as of FB2014_04, a new non-sequence-localized gene at 47D named 'crl'/'courtless' has been created, and CG4442 has been renamed to 'Ubc7'. The associated allelic and phenotypic data has been partitioned appropriately.
Source for identity of Ubc7 CG4443 was sequence comparison ( date:000516 ).
Source for identity of: Ubc7 CG4443
Source for identity of: Ubc7 crl
