Gene model reviewed during 5.47
Fourth of four related adjacent genes.
There is only one protein coding transcript and one polypeptide associated with this gene
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\AOX1 using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signalsView Dmel\AOX1 in GBrowse 2
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Name changed from lpo to Po in order to conform to terminology for other structural genes for enzymes.
The structural gene for the enzyme, pyridoxal oxidase (PO); molecular weight approximately 225,000 daltons. Enzymatic characterization by Hanley (1980). Substrate specificities explored by Cypher, Tedesco, Courtright and Kumaran (1982). As PO is a molybdenum-containing protein (Warner and Finnerty, 1981), its activity is absent from cin, mal and lxd flies, but cross-reacting material is present in the latter two (but not the former) genotypes (Warner, Watts and Finnerty, 1980). Enzyme activity present in all major organs except cardia, crop, imaginal discs, ovarian follicle cells, paragonia, pericardial cells and wreath cells (Cypher et al., 1982). Developmental profile shows dramatic increase in activity beginning in late pupa and continuing into adult life (Dickinson and Weisbrod, 1976). The nearly amorphic allele, Polpo, exhibits 2% normal activity; little if any cross reacting material is detectable in Polpo.