FB2021_06, released December 14, 2021

Gene: Dmel\kl-3

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General Information
Symbol
Dmel\kl-3
Species
D. melanogaster
Name
male fertility factor kl3
Annotation Symbol
CG45785
Feature Type
protein_coding_gene
FlyBase ID
FBgn0267432
Gene Model Status
Current
Stock Availability
6 publicly available
Gene Summary
male fertility factor kl3 (kl-3) encodes a dynein heavy chain that is a component of a microtubule motor complex. This motor activity is essential only for spermatogenesis. Lack of kl-3 results in loss of the axonemal out dynein arms in the spermatid tail. [Date last reviewed: 2019-03-14] (FlyBase Gene Snapshot)
All Summaries
Also Known As

kl3, Lms3

Key Links
Genomic Location
Cytogenetic map
h8-h8
Sequence location
Recombination map
Y-
RefSeq locus
NC_024512 REGION:336381..563165
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (10 terms)
Molecular Function (4 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (4 terms)
CV Term
Evidence
References
enables ATP binding
inferred from electronic annotation with InterPro:IPR011704
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
enables dynein intermediate chain binding
inferred from biological aspect of ancestor with PANTHER:PTN000743491
(assigned by GO_Central )
(Gaudet et al., 2011)
enables dynein light intermediate chain binding
inferred from biological aspect of ancestor with PANTHER:PTN000743491
(assigned by GO_Central )
(Gaudet et al., 2011)
enables minus-end-directed microtubule motor activity
inferred from sequence or structural similarity with UniProtKB:A8JDH8
(FlyBase Curators, 2008--)
inferred from biological aspect of ancestor with PANTHER:PTN000743491
(assigned by GO_Central )
(Gaudet et al., 2011)
Biological Process (3 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
involved_in cilium movement
inferred from sequence or structural similarity with UniProtKB:Q8TE73
(FlyBase Curators, 2008--)
involved_in microtubule-based movement
inferred from biological aspect of ancestor with PANTHER:PTN000743491
(assigned by GO_Central )
(Gaudet et al., 2011)
involved_in outer dynein arm assembly
inferred from biological aspect of ancestor with PANTHER:PTN002472868
(assigned by GO_Central )
(Gaudet et al., 2011)
Cellular Component (3 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
part_of axonemal dynein complex
inferred from mutant phenotype
(Goldstein et al., 1982)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
part_of dynein complex
inferred from biological aspect of ancestor with PANTHER:PTN000743491
(assigned by GO_Central )
(Gaudet et al., 2011)
part_of outer dynein arm
inferred from sequence or structural similarity with UniProtKB:Q8TE73
(FlyBase Curators, 2008--)
inferred from biological aspect of ancestor with PANTHER:PTN002472868
(assigned by GO_Central )
(Gaudet et al., 2011)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Snapshot
male fertility factor kl3 (kl-3) encodes a dynein heavy chain that is a component of a microtubule motor complex. This motor activity is essential only for spermatogenesis. Lack of kl-3 results in loss of the axonemal out dynein arms in the spermatid tail. [Date last reviewed: 2019-03-14]
Gene Group (FlyBase)
AXONEMAL OUTER ARM DYNEIN HEAVY CHAINS -
Dynein heavy chains are minus end-directed microtubule motor proteins. Axonemal dynein complexes interact with adjacent microtubules in the axoneme. Coordinated binding and release of the axonemal dyneins slide the microtubules relative to each other causing the axoneme to bend driving ciliary and flagellar motion. Axonemal outer arm dynein heavy chains are the microtubule-binding motor protein of the dynein outer arm. (Adapted from FBrf0230280).
Phenotypic Description (Red Book; Lindsley and Zimm 1992)
kl-3
Males mutant for kl-3 fail to assemble the outer dynein arms associated with the peripheral nine microtubule doublets of the sperm-tail axoneme [Hardy, Tokuyasu, and Lindsley, 1981, Chromosoma 83: 593-617 (fig.)]. Such males also fail to produce a kl-3-specific 300-325 kilodalton sperm polypeptide presumed to be a component of the outer dynein arms (Goldstein, Hardy, and Lindsley, 1982, Proc. Nat. Acad. Sci. USA 79: 7404-09). Such mutants display an exceedingly low level of fertility at 25 but not at 18 immediately upon eclosion, but not thereafter (Kennison, 1983, Genetics 103: 219-34). Deficiencies for kl-3 are completely sterile, and in addition to the above mutant phenotype, they fail to elaborate the loops (ribbon-like structure) observed in the primary spermatocyte nuclei of normal males by light microscopy and the reticular material ordinarily observed by electron microscopy in spermatocyte nuclei (Hardy et al., 1981). The kl-3 loops are visible in living spermatocytes and in fixed cells stained with the protein-specific dye CBB; these loops are also demonstrated by the polyclonal antibody Sph-155 but do not react with monoclonal antibody S5 (Bonaccorsi et al., 1988).
Gene Model and Products
Number of Transcripts
1
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\kl-3 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Gene model reviewed during 6.01

Gene model reviewed during 6.02

Sequence Ontology: Class of Gene
nuclear_gene
(Drosophila Heterochromatin Genome Project, 2007)
protein_coding_gene
(Drosophila Heterochromatin Genome Project, 2007)
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
kl-3-RC
FBtr0346771
NM_001111012
13882
4593
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\kl-3 using the Feature Mapper tool.

External Data
Crossreferences
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
mutational analysis
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage | male
spermatogonium

Comment: data from FlyAtlas

(Zur Lage et al., 2019)
RT-PCR
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage | male
spermatogonium
(Zur Lage et al., 2019)
Additional Descriptive Data

As part of a survey of ciliary motility gene homologs in Drosophila, expression of kl-3 was assayed in motile ciliated cell types. Expression was observed in sperm (testis) but not chordotonal neurons.

(Zur Lage et al., 2019)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
day 5 of adulthood & male -- day 7 of adulthood & male
spermatozoon
(Wasbrough et al., 2010)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
part_of axonemal dynein complex
inferred from mutant phenotype
(Goldstein et al., 1982)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\kl-3 in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 24 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 4 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of kl-3
Transgenic constructs containing regulatory region of kl-3
Aberrations (Deficiencies and Duplications) ( 73 )
Inferred from experimentation ( 73 )
Gene disrupted in
Df(YL)A10
(Hazelrigg et al., 1982)
Df(YL)A11
(Hazelrigg et al., 1982)
Df(YL)A17
(Hazelrigg et al., 1982)
Df(YL)A32
(Hazelrigg et al., 1982)
Df(YL)A39
(Hazelrigg et al., 1982)
Df(YL)A49
(Hazelrigg et al., 1982)
Df(YL)B4
(Hazelrigg et al., 1982)
Df(YL)B12
(Hazelrigg et al., 1982)
Df(YL)B14
(Hazelrigg et al., 1982)
Df(YL)G19
(Hardy et al., 1984)
Df(YL)G20
(Hardy et al., 1984)
Df(YL)G21
(Hardy et al., 1984)
Df(YL)G22
(Hardy et al., 1984)
Df(YL)G23
(Hardy et al., 1984)
Df(YL)G24
(Hardy et al., 1984)
Df(YL)H121
(Bonaccorsi and Lohe, 1991)
Df(YL)S7
(Gatti and Pimpinelli, 1983)
Df(YL)S8
(Gatti and Pimpinelli, 1983)
Df(YL)S9
(Gatti and Pimpinelli, 1983)
Df(YL)S10
(Gatti and Pimpinelli, 1983)
Df(YL)S11
(Gatti and Pimpinelli, 1983)
Df(YL)S13
(Gatti and Pimpinelli, 1983)
Df(YL)S14
(Gatti and Pimpinelli, 1983)
In(YL)B2
(Gatti and Pimpinelli, 1983)
In(YL)S15
(Gatti and Pimpinelli, 1983)
In(YL)S16L
(Gatti and Pimpinelli, 1983)
T(1;Y)R39
T(1;Y)S1
T(1;Y)S2
T(1;Y)S24
T(1;Y)T13
(Bonaccorsi and Lohe, 1991)
T(1;Y)V57
T(Y;2)G74
(Bonaccorsi and Lohe, 1991, Gatti and Pimpinelli, 1983)
T(Y;2)P57
(Bonaccorsi and Lohe, 1991, Gatti and Pimpinelli, 1983)
T(Y;3)D107
(Gatti and Pimpinelli, 1983)
T(Y;3)S20
(Gatti and Pimpinelli, 1983)
Ts(1Lt;YSt)E15
(Zhang and Stankiewicz, 1998)
Ts(1Lt;YSt)F12
(Zhang and Stankiewicz, 1998)
Ts(1Lt;YSt)T13
(Bonaccorsi et al., 1990)
Ts(1Lt;YSt)W27
(Zhang and Stankiewicz, 1998)
Ts(1Rt;YLt)V24
(Bonaccorsi et al., 1990)
Ts(1Rt;YSt)V8
(Bonaccorsi et al., 1990)
Ts(1Rt;YSt)W19
(Bonaccorsi et al., 1990)
Ts(YSt;4Rt)B15
(Hazelrigg et al., 1982)
Gene not disrupted in
Df(YL)S5
(Gatti and Pimpinelli, 1983)
Df(YL)S6
(Gatti and Pimpinelli, 1983)
Df(YS)A6
(Hazelrigg et al., 1982)
Df(YS)B13
(Hazelrigg et al., 1982)
In(YL)B3
(Gatti and Pimpinelli, 1983)
In(YLS)A33
(Hazelrigg et al., 1982)
In(YLS)B1
(Gatti and Pimpinelli, 1983)
In(YLS)S18
(Gatti and Pimpinelli, 1983)
T(1;Y)V24
(Gatti and Pimpinelli, 1983)
T(Y;2)A169
(Gatti and Pimpinelli, 1983)
T(Y;2)B3
(Hazelrigg et al., 1982)
T(Y;2)B13
(Hazelrigg et al., 1982)
T(Y;2)B92
(Gatti and Pimpinelli, 1983)
T(Y;2)B242
(Gatti and Pimpinelli, 1983)
T(Y;2)J146
(Gatti and Pimpinelli, 1983)
T(Y;2)R155
(Gatti and Pimpinelli, 1983)
T(Y;3)A23
(Gatti and Pimpinelli, 1983)
T(Y;3)A34
(Hazelrigg et al., 1982)
T(Y;3)A112
(Gatti and Pimpinelli, 1983)
T(Y;3)B115
(Gatti and Pimpinelli, 1983)
T(Y;3)B223
(Gatti and Pimpinelli, 1983)
T(Y;3)B229
(Gatti and Pimpinelli, 1983)
T(Y;3)S21
(Gatti and Pimpinelli, 1983)
Ts(1Lt;YLt)V8
(Zhang and Stankiewicz, 1998)
Ts(1Lt;YLt)W19
(Zhang and Stankiewicz, 1998)
Ts(1Lt;YSt)V24
(Zhang and Stankiewicz, 1998)
Ts(YLt;3Lt)W27
(Bonaccorsi et al., 1990)
Ts(YLt;3Rt)A34
(Hazelrigg et al., 1982)
Ts(YLt;4Lt)B15
(Hazelrigg et al., 1982)
Inferred from location ( 0 )
    Alleles Representing Disease-Implicated Variants
    Phenotypes
    Orthologs
    Downloads
    Download All DIOPT Orthologs
    Download All OrthoDB Orthologs
    Human Orthologs (via DIOPT v8.0)
    Homo sapiens (Human) (13)
    Species\Gene Symbol
    Score
    Best Score
    Best Reverse Score
    Source
    Compara
    eggNOG
    Hieranoid
    Homologene
    Inparanoid
    Isobase
    OMA
    OrthoDB
    OrthoFinder
    OrthoInspector
    orthoMCL
    Panther
    Phylome
    RoundUp
    TreeFam
    ZFIN
    Alignment
    Complementation?
    Transgene?
    Hsap\DNAH5
    6 of 15
    Yes
    No
    Hsap\DNAH8
    5 of 15
    No
    No
    Hsap\DNAH10
    2 of 15
    No
    No
    Hsap\DNAH1
    1 of 15
    No
    No
    Hsap\DNAH2
    1 of 15
    No
    No
    Hsap\DNAH3
    1 of 15
    No
    No
    Hsap\DNAH6
    1 of 15
    No
    No
    Hsap\DNAH7
    1 of 15
    No
    No
    Hsap\DNAH9
    1 of 15
    No
    No
    Hsap\DNAH11
    1 of 15
    No
    No
    Hsap\DNAH12
    1 of 15
    No
    No
    Hsap\DNAH14
    1 of 15
    No
    No
    Hsap\DNAH17
    1 of 15
    No
    No
    Model Organism Orthologs (via DIOPT v8.0)
    Mus musculus (laboratory mouse) (15)
    Species\Gene Symbol
    Score
    Best Score
    Best Reverse Score
    Source
    Compara
    eggNOG
    Hieranoid
    Homologene
    Inparanoid
    Isobase
    OMA
    OrthoDB
    OrthoFinder
    OrthoInspector
    orthoMCL
    Panther
    Phylome
    RoundUp
    TreeFam
    ZFIN
    Alignment
    Complementation?
    Transgene?
    Mmus\Dnah5
    6 of 15
    Yes
    No
    Mmus\Dnah8
    5 of 15
    No
    No
    Mmus\Dnah1
    1 of 15
    No
    No
    Mmus\Dnah2
    1 of 15
    No
    No
    Mmus\Dnah3
    1 of 15
    No
    No
    Mmus\Dnah6
    1 of 15
    No
    No
    Mmus\Dnah7a
    1 of 15
    No
    No
    Mmus\Dnah7b
    1 of 15
    No
    No
    Mmus\Dnah7c
    1 of 15
    No
    No
    Mmus\Dnah9
    1 of 15
    No
    No
    Mmus\Dnah10
    1 of 15
    No
    No
    Mmus\Dnah11
    1 of 15
    No
    No
    Mmus\Dnah12
    1 of 15
    No
    No
    Mmus\Dnah14
    1 of 15
    No
    Yes
    Mmus\Dnah17
    1 of 15
    No
    No
    Rattus norvegicus (Norway rat) (13)
    Rnor\Dnah5
    4 of 13
    Yes
    No
    Rnor\Dnah8
    3 of 13
    No
    No
    Rnor\Dnah10
    2 of 13
    No
    No
    Rnor\Dnah1
    1 of 13
    No
    No
    Rnor\Dnah2
    1 of 13
    No
    No
    Rnor\Dnah3
    1 of 13
    No
    No
    Rnor\Dnah6
    1 of 13
    No
    No
    Rnor\Dnah7
    1 of 13
    No
    No
    Rnor\Dnah9
    1 of 13
    No
    No
    Rnor\Dnah11
    1 of 13
    No
    No
    Rnor\Dnah12
    1 of 13
    No
    No
    Rnor\Dnah14
    1 of 13
    No
    No
    Rnor\Dnah17
    1 of 13
    No
    No
    Xenopus tropicalis (Western clawed frog) (14)
    Xtro\dnah5
    2 of 12
    Yes
    No
    Xtro\dnah10
    2 of 12
    Yes
    No
    Xtro\LOC100488102
    2 of 12
    Yes
    Yes
    Xtro\dnah1
    1 of 12
    No
    No
    Xtro\dnah2
    1 of 12
    No
    No
    Xtro\dnah3
    1 of 12
    No
    No
    Xtro\dnah6
    1 of 12
    No
    No
    Xtro\dnah7
    1 of 12
    No
    No
    Xtro\dnah9
    1 of 12
    No
    No
    Xtro\dnah11
    1 of 12
    No
    No
    Xtro\dnah12
    1 of 12
    No
    No
    Xtro\dnah14
    1 of 12
    No
    No
    Xtro\LOC100490346
    1 of 12
    No
    No
    Xtro\LOC100497531
    1 of 12
    No
    No
    Danio rerio (Zebrafish) (11)
    Drer\dnah5
    5 of 15
    Yes
    Yes
    Drer\dnah5l
    4 of 15
    No
    No
    Drer\si:dkeyp-86b9.1
    2 of 15
    No
    No
    Drer\dnah1
    1 of 15
    No
    No
    Drer\dnah2
    1 of 15
    No
    No
    Drer\dnah3
    1 of 15
    No
    No
    Drer\dnah6
    1 of 15
    No
    No
    Drer\dnah7
    1 of 15
    No
    No
    Drer\dnah9
    1 of 15
    No
    No
    Drer\dnah9l
    1 of 15
    No
    No
    Drer\dnah12
    1 of 15
    No
    No
    Caenorhabditis elegans (Nematode, roundworm) (0)
    No records found.
    Arabidopsis thaliana (thale-cress) (0)
    No records found.
    Saccharomyces cerevisiae (Brewer's yeast) (0)
    No records found.
    Schizosaccharomyces pombe (Fission yeast) (1)
    Spom\dhc1
    2 of 12
    Yes
    No
    Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( None identified )
    No orthologies identified
    Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG0915001A )
    Organism
    Common Name
    Gene
    Multiple Dmel Genes in this Orthologous Group
    Musca domestica
    House fly
    Mdoa\17015443
    Glossina morsitans
    Tsetse fly
    Gmor\GMOY004878
    Lucilia cuprina
    Australian sheep blowfly
    Lcup\FF38_05250
    Aedes aegypti
    Yellow fever mosquito
    Aaeg\AAEL007225
    Anopheles darlingi
    American malaria mosquito
    Adar\ADAC001899
    Anopheles gambiae
    Malaria mosquito
    Agam\AGAP007675
    Culex quinquefasciatus
    Southern house mosquito
    Cqui\CPIJ012527
    Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W000Z )
    Organism
    Common Name
    Gene
    Multiple Dmel Genes in this Orthologous Group
    Bombyx mori
    Silkmoth
    Bmor\BGIBMGA002144
    Bombyx mori
    Silkmoth
    Bmor\BGIBMGA003690
    Bombyx mori
    Silkmoth
    Bmor\BGIBMGA002148
    Danaus plexippus
    Monarch butterfly
    Dple\DPOGS203998-PA
    Danaus plexippus
    Monarch butterfly
    Dple\DPOGS203785-PA
    Danaus plexippus
    Monarch butterfly
    Dple\DPOGS201355-PA
    Danaus plexippus
    Monarch butterfly
    Dple\DPOGS203786-PA
    Heliconius melpomene
    Postman butterfly
    Hmel\HMEL012849
    Heliconius melpomene
    Postman butterfly
    Hmel\HMEL005947
    Heliconius melpomene
    Postman butterfly
    Hmel\HMEL013863
    Apis florea
    Little honeybee
    Aflo\2147496531
    Apis florea
    Little honeybee
    Aflo\3731910980
    Apis mellifera
    Western honey bee
    Amel\GB54468
    Apis mellifera
    Western honey bee
    Amel\GB49507
    Bombus impatiens
    Common eastern bumble bee
    Bimp\BIMP15694
    Bombus impatiens
    Common eastern bumble bee
    Bimp\BIMP21035
    Bombus terrestris
    Buff-tailed bumblebee
    Bter\15202990
    Bombus terrestris
    Buff-tailed bumblebee
    Bter\15211333
    Bombus terrestris
    Buff-tailed bumblebee
    Bter\15212790
    Bombus terrestris
    Buff-tailed bumblebee
    Bter\15211332
    Linepithema humile
    Argentine ant
    Lhum\LH21811
    Linepithema humile
    Argentine ant
    Lhum\LH18089
    Megachile rotundata
    Alfalfa leafcutting bee
    Mrot\MROTU:0029e0
    Megachile rotundata
    Alfalfa leafcutting bee
    Mrot\MROTU:000f49
    Megachile rotundata
    Alfalfa leafcutting bee
    Mrot\MROTU:002cd3
    Nasonia vitripennis
    Parasitic wasp
    Nvit\Nasvi2EG013890
    Nasonia vitripennis
    Parasitic wasp
    Nvit\Nasvi2EG017694
    Dendroctonus ponderosae
    Mountain pine beetle
    Dpod\YQE_04556
    Dendroctonus ponderosae
    Mountain pine beetle
    Dpod\YQE_09854
    Tribolium castaneum
    Red flour beetle
    Tcas\TC000076
    Tribolium castaneum
    Red flour beetle
    Tcas\TC034619
    Tribolium castaneum
    Red flour beetle
    Tcas\TC000077
    Pediculus humanus
    Human body louse
    Phum\PHUM247970
    Pediculus humanus
    Human body louse
    Phum\PHUM561990
    Rhodnius prolixus
    Kissing bug
    Rpro\RPRC004988
    Cimex lectularius
    Bed bug
    Clec\CLEC008864
    Acyrthosiphon pisum
    Pea aphid
    Apim\ACYPI005174
    Zootermopsis nevadensis
    Nevada dampwood termite
    Znev\Znev_07035
    Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X000Y )
    Organism
    Common Name
    Gene
    Multiple Dmel Genes in this Orthologous Group
    Strigamia maritima
    European centipede
    Smar\SMAR007660
    Strigamia maritima
    European centipede
    Smar\SMAR010821
    Stegodyphus mimosarum
    African social velvet spider
    Smim\KFM58683.1
    Stegodyphus mimosarum
    African social velvet spider
    Smim\KFM83564.1
    Stegodyphus mimosarum
    African social velvet spider
    Smim\KFM57315.1
    Daphnia pulex
    Water flea
    Dpux\DAPPUDRAFT_316462
    Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G001E )
    Organism
    Common Name
    Gene
    Multiple Dmel Genes in this Orthologous Group
    Strongylocentrotus purpuratus
    Purple sea urchin
    Spur\Sp-Dnahc5
    Strongylocentrotus purpuratus
    Purple sea urchin
    Spur\Sp-Axndhc8h
    Strongylocentrotus purpuratus
    Purple sea urchin
    Spur\Sp-Axndhc15h
    Strongylocentrotus purpuratus
    Purple sea urchin
    Spur\SPU_009127gn
    Strongylocentrotus purpuratus
    Purple sea urchin
    Spur\Sp-Axndhc5h
    Strongylocentrotus purpuratus
    Purple sea urchin
    Spur\Sp-Unk_101
    Strongylocentrotus purpuratus
    Purple sea urchin
    Spur\Sp-Dnah5
    Strongylocentrotus purpuratus
    Purple sea urchin
    Spur\SPU_014620gn
    Strongylocentrotus purpuratus
    Purple sea urchin
    Spur\Sp-Dnah5-2
    Strongylocentrotus purpuratus
    Purple sea urchin
    Spur\Sp-Dnah5_1
    Ciona intestinalis
    Vase tunicate
    Cint\ENSCING00000008991
    Ciona intestinalis
    Vase tunicate
    Cint\ENSCING00000004223
    Ciona intestinalis
    Vase tunicate
    Cint\ENSCING00000024018
    Gallus gallus
    Domestic chicken
    Ggal\ENSGALG00000013268
    Gallus gallus
    Domestic chicken
    Ggal\DNAH5
    Gallus gallus
    Domestic chicken
    Ggal\DNAH8
    Paralogs
    Downloads
    Download All DIOPT Paralogs
    Paralogs (via DIOPT v8.0)
    Drosophila melanogaster (Fruit fly) (14)
    Gene Symbol
    Score
    Source
    Compara
    eggNOG
    Homologene
    Inparanoid
    Isobase
    OrthoDB
    OrthoFinder
    orthoMCL
    Panther
    RoundUp
    Alignment
    Dhc1
    4 of 10
    Dhc98D
    4 of 10
    CG3339
    3 of 10
    Dhc16F
    3 of 10
    Dhc36C
    3 of 10
    Dhc93AB
    3 of 10
    Dnah3
    3 of 10
    kl-2
    3 of 10
    btv
    2 of 10
    CG14651
    2 of 10
    Dhc62B
    2 of 10
    Dhc64C
    2 of 10
    kl-5
    2 of 10
    CG9068
    1 of 10
    Human Disease Associations
    FlyBase Human Disease Model Reports
      Disease Model Summary Ribbon
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Allele
      Disease
      Evidence
      References
      Potential Models Based on Orthology ( 1 )
      Human Ortholog
      Disease
      Evidence
      References
      DNAH5; dynein axonemal heavy chain 5
      model of  primary ciliary dyskinesia 3
      IEA
      (FlyBase, 2019-)
      Modifiers Based on Experimental Evidence ( 0 )
      Allele
      Disease
      Interaction
      References
      Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
      Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
      Homo sapiens (Human)
      Gene name
      Score
      OMIM
      OMIM Phenotype
      DO term
      Complementation?
      Transgene?
      DNAH5; dynein axonemal heavy chain 5
      6 of 15
      603335
      DNAH8; dynein axonemal heavy chain 8
      5 of 15
      603337
      Functional Complementation Data
      Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
      Interactions
      Summary of Physical Interactions
      esyN Network Diagram
      Interactions Browser
      Summary of Genetic Interactions
      esyN Network Diagram
      Starting gene(s)
      Interaction type
      Interacting gene(s)
      Reference
      Starting gene(s)
      Interaction type
      Interacting gene(s)
      Reference
      External Data
      Linkouts
      DroID - A comprehensive database of gene and protein interactions.
      Pathways
      Signaling Pathways (FlyBase)
      Metabolic Pathways
      External Data
      Linkouts
      Genomic Location and Detailed Mapping Data
      Chromosome (arm)
      Y
      Recombination map
      Y-
      Cytogenetic map
      h8-h8
      Sequence location
      FlyBase Computed Cytological Location
      Cytogenetic map
      Evidence for location
      h8-h8
      Left limit from complementation mapping against T(Y;3)S20 (FBrf0039037) Right limit from complementation mapping against T(Y;3)D107 (FBrf0039037)
      Experimentally Determined Cytological Location
      Cytogenetic map
      Notes
      References
      h7-h9
      (Drosophila Heterochromatin Genome Project, 2004, Zhang et al., 1996)
      Maps to the region of kl-3.
      (Zhang, 1996.4.28)
      h7-h9
      (determined by in situ hybridisation)
      (Zhang and Stankiewicz, 1998)
      Experimentally Determined Recombination Data
      Location

      Y-

      (Hackstein and Hochstenbach, 1995)
      Left of (cM)
      Right of (cM)
      Notes
      Stocks and Reagents
      Stocks (6)
      Genomic Clones (3)
       

      Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

      cDNA Clones (17)
       

      Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

      cDNA clones, fully sequenced
      BDGP DGC clones
      Other clones
        Drosophila Genomics Resource Center cDNA clones

        For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

          cDNA Clones, End Sequenced (ESTs)
          BDGP DGC clones
          Other clones
          RNAi and Array Information
          Linkouts
          GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
          Antibody Information
          Laboratory Generated Antibodies
           
          Commercially Available Antibodies
           
          Other Information
          Relationship to Other Genes
          Source for database identify of
          Source for database merge of

          Source for merge of: kl-3 CG17629

          (FlyBase, 1996-)

          Source for merge of: kl-3 CG40992 CG40936

          (FlyBase Genome Annotators, 2014)
          Additional comments

          Annotations CG40992, CG40936 and CG17629 merged as CG45785 in release 6.02 of the genome annotation. This gene is no longer fragmented in the release 6 genome assembly.

          (FlyBase Genome Annotators, 2014)

          Source for merge of kl-3 CG17629 was sequence comparison ( date:001108 ).

          (FlyBase, 1996-)

          Williamson (1972) reported 23 non-complementing and nine complementing alleles induced by EMS.

          Other Comments

          Sequence of transcript(s) changed in r6 genomic release relative to r5 release.

          (FlyBase Genome Annotators, 2014)

          New annotation (CG40992) in release 5.2 of the genome annotation.

          (Drosophila Heterochromatin Genome Project, 2007)

          New annotation (CG40936) in release 5.2 of the genome annotation.

          (Drosophila Heterochromatin Genome Project, 2007)

          Transiently named CG40443 in release 3 of the genome annotation.

          (FlyBase Genome Annotators, 2002-2003)

          It is not yet known if "ms(Y)104b" is the same as kl-3.

          (Zhang, 1996.4.28)

          Primary spermatocyte nuclei exhibit three giant lampbrush-like loops formed by the kl-5, kl-3 and ks-1 Y chromosome fertility factors.

          (Pisano et al., 1993)

          Males mutant for kl-3 fail to assemble the outer dynein arms associated with the peripheral nine microtubule doublets of the sperm-tail axoneme (Hardy, Tokuyasu, and Lindsley, 1981). Such males also fail to produce a kl-3-specific 300-325 kilodalton sperm polypeptide presumed to be a component of the outer dynein arms (Goldstein, Hardy and Lindsley, 198). Such mutants display an exceedingly low level of fertility at 25oC but not at 18oC immediately upon eclosion, but not thereafter (Kennison, 1983). Deficiencies for kl-3 are completely sterile, and in addition to the above mutant phenotype, they fail to elaborate the loops (ribbon-like structure) observed in the primary spermatocyte nuclei of normal males by light microscopy and the reticular material ordinarily observed by electron microscopy in spermatocyte nuclei (Hardy et al., 1981). The kl-3 loops are visible in living spermatocytes and in fixed cells stained with the protein-specific dye CBB; these loops are also demonstrated by the polyclonal antibody Sph-155 but do not react with monoclonal antibody S5 (Bonaccorsi et al., 1988).

          Origin and Etymology
          Discoverer
          Etymology
          Identification
          External Crossreferences and Linkouts ( 40 )
          Sequence Crossreferences
          NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
          GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
          GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
          RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
          UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
          Other crossreferences
          DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
          EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
          FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
          FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
          GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
          iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
          InterPro - A database of protein families, domains and functional sites
          KEGG Genes - Molecular building blocks of life in the genomic space.
          MARRVEL_MODEL - MARRVEL (model organism gene)
          Linkouts
          DroID - A comprehensive database of gene and protein interactions.
          Synonyms and Secondary IDs (17)
          Datasets (0)
          Study focus (0)
          Experimental Role
          Project
          Project Type
          Title
          References (103)