24B10, mAb24B10, chaoptic, 516, INAD localization-A
Gene model reviewed during 5.53
Stop-codon suppression (UGA) postulated; FBrf0216884.
Gene model reviewed during 5.44
Gene model reviewed during 5.47
None of the polypeptides share 100% sequence identity.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\chp using the Feature Mapper tool.
chp protein is expressed in photoreceptor cell soma and their axons.
Expressed specifically on the photoreceptor plasma membrane, strongly labeling the photoreceptor axons.
Complete disappearance of Bolwig's nerve occurs between 8 and 16 hours APF, as judged by chp immunostaining.
GBrowse - Visual display of RNA-Seq signalsView Dmel\chp in GBrowse 2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for identity of: chp CG1744
Source for merge of: chp idl-A
The "idl-A" complementation probably corresponds to alleles of the "chp" locus; idl-A mutants fail to complement hypomorphic chp alleles for inaD mislocalisation and retinal degeneration.
FlyBase curator comment: Full-name of 'chp' changed from 'chaoptic' to 'chaoptin' to reflect overwhelming community usage and reduce confusion.
The biophysical and biochemical characteristics of a synthetic Leu-rich repeat peptide (CRP32) generated from the sequence of one of the repeats found in chp is studied.
Biochemical analyses demonstrate that chp is linked to the extracellular surface by covalent attachment to glycosyl-phosphotidylinositol: chp is required for photoreceptor cell morphogenesis. Results suggest that chp and other members of the leucine rich repeat family of proteins define a new class of cell adhesion molecules.
chp mutants have disorganized rhabdomere organization.
Developmental expression pattern of the cDNA clone is examined.
Identified as a cDNA clone that is expressed at a low frequency in the body but abundantly in the head of the adult.
The structural gene encoding chaoptin, a 160kD glycoprotein localized to the extracellular membrane surface of photoreceptor cells and their axonal projections to the optic ganglia. Protein first identified by a monoclonal antibody (MAb24B10). Antigen first appears behind the morphogenetic furrow during differentiation of the eye imaginal disk. Defective alleles, chp1 and chp2, recognized by reduced levels of antigen. Rhabdomeres of mutant photoreceptor cells highly deranged or nearly absent in homozygotes and hemizygotes for chp1 or chp2, respectively; also close apposition of adjacent retinular cells partially disrupted. Gene product postulated to play role in cell surface interactions necessary for correct alignment of the microvilli that form the rhabdomeres.