DPTP61F, protein tyrosine phosphatase
Gene model reviewed during 5.52
Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.42
2.8, 2.0 (northern blot)
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Ptp61F using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signalsView Dmel\Ptp61F in GBrowse 2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for merge of Ptp61F BEST:LP01280 was a shared cDNA ( date:030206 ).
Source for merge of Ptp61F anon-WO0140519.98 anon-WO0118547.297 was sequence comparison ( date:051113 ).
Ptp61F negatively regulates JAK/STAT signaling and is also a transcriptional target of JAK/STAT signaling.
S2-derived S2-NP cells treated with dsRNA made from templates generated with primers directed against Ptp61F experience a more than four-fold increase in Stat92E-dependent reporter activity and a significant increase in Stat92E phosphorylation. dsRNA knock-down also results in a dramatic increase in tyrosine phosphorylation of hop protein.
dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
Area matching Drosophila EST AA567483 (inverted).
The spatial and temporal expression of two alternative transcripts of Ptp61F during Drosophila embryogenesis has been analysed in wild-type embryos and in embryos mutant for pair-rule and segment-polarity genes.
Spatial and temporal transcript accumulation pattern in ovaries is determined by in situ hybridisation.
Two 3' splice variants of this gene generate two proteins that differ in their C-termini. One is targeted to the cytoplasmic membrane, the other to the nucleus.