Gene model reviewed during 6.02
Corresponds to Mst77Y-4 (FBgn0262753)
Detailed characterization of the Mst77Y region (FBrf0228674) indicates that the release 6 assembly is only approximately correct in this region. The presence of 18 genes is confirmed, however, there are errors in the order and the precise sequences of the genes. The revised prediction is of 10 functional copies and 8 pseudogenes. Further explanation may be found in the 'Other Information' section of the gene report, 'Additional Comments' under 'Relationship to Other Genes.'
There is only one protein coding transcript and one polypeptide associated with this gene
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Mst77Y-4 using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signalsView Dmel\Mst77Y-4 in GBrowse 2
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for merge of:Mst77Y-4 CG45763
The Mst77Y region was re-evaluated using long-read single molecule sequencing technology. It was found that 6 previously identified genes (Mst77Y-2, Mst77Y-8, Mst-77Y-9, Mst77Y-5Ψ, Mst77Y-11Ψ, and Mst77y-14Ψ) were probable artifacts. Multiple new genes were identified that correspond to duplicate copies of previously identified genes. The current release 6 assembly is not entirely correct, in the order or precise sequence of the genes. The current prediction is of 10 functional copies and 8 pseudogenes in the following order, all transcribed from the plus strand: Mst77Y-17Ψ, Mst77Y-10Ψ, Mst77Y-1, Mst77Y-13, Mst77Y-3Ψ, Mst77Y-7a, Mst77Y-12a, Mst77Y-7b, Mst77Y-6aΨ, Mst77Y-6bΨ, Mst77Y-12b, Mst77Y-4a, Mst77Y-12c, Mst77Y-4b, Mst77Y-4c, Mst77Y-15Ψ, Mst77Y-16Ψ, Mst77Y-18Ψ.
"Mst77Y-4" is one of 18 Y-linked genes that are related to the Mst77F gene (which is located on 3L). Evidence suggests that these multiple copies originated from a single duplication from the autosome to the Y chromosome, followed by duplications inside the Y. Ten of these Y-linked genes encode defective proteins (Mst77Y-3Ψ, Mst77Y-5Ψ, Mst77Y-6Ψ, Mst77Y-10Ψ, Mst77Y-11Ψ, Mst77Y-14Ψ, Mst77Y-15Ψ, Mst77Y-16Ψ, Mst77Y-17Ψ and Mst77Y-18Ψ) and the other eight are potentially functional (Mst77Y-1, Mst77Y-2, Mst77Y-4, Mst77Y-7, Mst77Y-8, Mst77Y-9, Mst77Y-12 and Mst77Y-13). The eight potentially functional genes produce approximately 20% of the functional Mst77F-like mRNA and evolved under purifying selection.
The 96 kb located at coordinates 85040-180612 of contig JSAE01000257 accurately represent the Mst77Y cluster.
New annotation (CG45763) in release 6.02 of the genome annotation.