Gene model reviewed during 6.02
Gene model reviewed during 5.46
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.55
A non-AUG start codon may be used for translation of one or more transcripts of this gene; based on the presence of conserved protein signatures within the 5' UTR without an in-frame AUG (FBrf0243886).
None of the polypeptides share 100% sequence identity.
Self-associates. Interacts (via GBD/FH3 domain) with Cdc42; the interaction is stronger with the GTP bound form of Cdc42.
The DAD domain regulates activation via by an autoinhibitory interaction with the GBD/FH3 domain. This autoinhibition is released upon competitive binding of an activated GTPase. The release of DAD allows the FH2 domain to then nucleate and elongate nonbranched actin filaments.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Frl using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signalsView Dmel\Frl in GBrowse 2
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for identity of: Frl CG32138
Annotation CG32138 merged with CG43986 in release 6.02 of the genome annotation; CG43986 appears to be non-coding and to correspond to an alternative 5' UTR exon of CG32138.
Annotations CG13485 and CG6807 merged as CG32138 in release 3 of the genome annotation.
Named 'Frl' as it is the sole representative of the Frl formin subfamily in flies.