FlyBase Gene Report: Dmel\Frl

General Information

Symbol

Dmel\Frl

Species

D. melanogaster

Name

Formin-like

Annotation Symbol

CG32138

Feature Type

protein_coding_gene

FlyBase ID

FBgn0267795

Gene Model Status

Stock Availability

11 publicly available

Gene Summary

Together with Cdc42, involved in establishment of planar cell polarity in the developing compound eye by contributing to ommatidial rotation. Together with DAAM and Cdc42, has a role in neuronal development of mushroom bodies. (UniProt, Q9VUC6)

Contribute a Gene Snapshot for this gene.

All Summaries

Alliance
Auto summary
UniProtKB
Interactive Fly

Key Links

Genomic Location

Cytogenetic map

Sequence location

3L:14,053,215..14,071,583 [+]

Recombination map

3-42

RefSeq locus

NT_037436 REGION:14053215..14071583

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse GBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

Gene Ontology (GO) Annotations (10 terms)

Molecular Function (3 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

enables GTPase binding

inferred from physical interaction with UniProtKB:P40792

(assigned by UniProt )

(Dollar et al., 2016)

enables small GTPase binding

inferred from physical interaction with UniProtKB:P40793

(assigned by UniProt )

(Dollar et al., 2016)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

enables actin filament binding

inferred from biological aspect of ancestor with PANTHER:PTN002509302

(assigned by GO_Central )

(Gaudet et al., 2011)

Biological Process (6 terms)

Terms Based on Experimental Evidence (3 terms)

CV Term

Evidence

References

involved_in axon extension

inferred from genetic interaction with FLYBASE:Cdc42; FB:FBgn0010341

(Dollar et al., 2016)

inferred from genetic interaction with FLYBASE:DAAM; FB:FBgn0025641

(Dollar et al., 2016)

involved_in mushroom body development

inferred from mutant phenotype

(Dollar et al., 2016)

involved_in ommatidial rotation

inferred from mutant phenotype

(Dollar et al., 2016)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

involved_in cell migration

inferred from biological aspect of ancestor with PANTHER:PTN002509302

(assigned by GO_Central )

(Gaudet et al., 2011)

involved_in cortical actin cytoskeleton organization

inferred from biological aspect of ancestor with PANTHER:PTN002509302

(assigned by GO_Central )

(Gaudet et al., 2011)

involved_in regulation of cell shape

inferred from biological aspect of ancestor with PANTHER:PTN002509302

(assigned by GO_Central )

(Gaudet et al., 2011)

Cellular Component (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

is_active_in cytosol

inferred from biological aspect of ancestor with PANTHER:PTN002509302

(assigned by GO_Central )

(Gaudet et al., 2011)

Gene Group (FlyBase)

Protein Family (UniProt)

Belongs to the formin homology family. (Q9VUC6)

Protein Signatures (InterPro)

Summaries

Protein Function (UniProtKB)

Together with Cdc42, involved in establishment of planar cell polarity in the developing compound eye by contributing to ommatidial rotation. Together with DAAM and Cdc42, has a role in neuronal development of mushroom bodies.

(UniProt, Q9VUC6)

Gene Model and Products

Number of Transcripts

4

Number of Unique Polypeptides

4

Please see the JBrowse view of Dmel\Frl for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Comments on Gene Model

Gene model reviewed during 6.02

Gene model reviewed during 5.46

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.55

A non-AUG start codon may be used for translation of one or more transcripts of this gene; based on the presence of conserved protein signatures within the 5' UTR without an in-frame AUG (FBrf0243886).

Sequence Ontology: Class of Gene

(FlyBase Genome Annotators, 2012)

protein_coding_gene

(FlyBase Genome Annotators, 2012)

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

FBtr0075775

4640

1183

FBtr0075776

4583

1164

FBtr0114573

5827

1174

FBtr0334053

4924

1113

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

FBpp0075517

133.2

1183

8.22

FBpp0075518

131.0

1164

8.26

FBpp0113065

132.0

1174

8.26

FBpp0306179

125.0

1113

8.02

Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Domain

The DAD domain regulates activation via by an autoinhibitory interaction with the GBD/FH3 domain. This autoinhibition is released upon competitive binding of an activated GTPase. The release of DAD allows the FH2 domain to then nucleate and elongate nonbranched actin filaments.

(UniProt, Q9VUC6)

Subunit Structure (UniProtKB)

Self-associates. Interacts (via GBD/FH3 domain) with Cdc42; the interaction is stronger with the GTP bound form of Cdc42.

(UniProt, Q9VUC6)

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Frl using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

CG32138_1

Linkouts

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

• membrane

(Aradska et al., 2015)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Frl in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Frl

View exonic expression by tissue for Dmel\Frl

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0267795

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

39561/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0267795

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0052138

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0267795

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG32138

Images

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 15 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 9 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Frl

Transgenic constructs containing regulatory region of Frl

Aberrations (Deficiencies and Duplications) ( 3 )

Inferred from experimentation ( 3 )

Gene partially disrupted in

(Dollar et al., 2016)

(Dollar et al., 2016)

Df(3L)Frl^ExK62

(Dollar et al., 2016)

Inferred from location ( 0 )

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

viable, with Scer\GAL4^Mef2.PR

Frl^GD10799

viable, with Scer\GAL4^pnr-MD237

Frl^GD10799

viable, with Scer\GAL4^tin.CΔ4

Frl^GD10799

Other Phenotypes

Allele

abnormal neuroanatomy | adult stage, with Scer\GAL4^ey-OK107

Frl^HMS00445

abnormal neuroanatomy | adult stage | somatic clone

abnormal planar polarity | adult stage, with Scer\GAL4^hs.2sev

abnormal planar polarity | adult stage, with Scer\GAL4^sev.EP

Frl^DN.UAS

abnormal planar polarity | adult stage | somatic clone - Minute background

abnormal planar polarity | third instar larval stage, with Scer\GAL4^sev.EP

Frl^DN.UAS

decreased cell number | adult stage, with Scer\GAL4^sev.EP

decreased cell number | third instar larval stage, with Scer\GAL4^sev.EP

Frl^DN.UAS

visible, with Scer\GAL4^hs.2sev

Phenotype manifest in

Allele

adult mushroom body alpha-lobe | adult stage, with Scer\GAL4^ey-OK107

Frl^HMS00445

adult mushroom body beta-lobe | adult stage, with Scer\GAL4^ey-OK107

Frl^HMS00445

axon | adult stage, with Scer\GAL4^ey-OK107

Frl^HMS00445

axon | adult stage | somatic clone

eye, with Scer\GAL4^hs.2sev

eye, with Scer\GAL4^sev.EP

eye | somatic clone - Minute background

eye disc | third instar larval stage, with Scer\GAL4^sev.EP

Frl^DN.UAS

eye photoreceptor cell, with Scer\GAL4^sev.EP

ommatidial precursor cluster | third instar larval stage, with Scer\GAL4^sev.EP

Frl^DN.UAS

ommatidium, with Scer\GAL4^hs.2sev

ommatidium, with Scer\GAL4^sev.EP

Frl^DN.UAS

ommatidium | somatic clone - Minute background

Orthologs

Downloads

Download All DIOPT Orthologs

Download All OrthoDB Orthologs

Human Orthologs (via DIOPT v8.0)

Homo sapiens (Human) (17)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

13 of 15

Yes

Yes

13 of 15

Yes

Yes

1

11 of 15

No

Yes

2 of 15

No

No

2 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

Yes

1 of 15

No

Yes

1 of 15

No

Yes

1 of 15

No

No

1 of 15

No

Yes

1 of 15

No

No

1 of 15

No

No

1

1 of 15

No

No

8

1 of 15

No

No

Model Organism Orthologs (via DIOPT v8.0)

Mus musculus (laboratory mouse) (13)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

13 of 15

Yes

Yes

12 of 15

No

Yes

12 of 15

No

Yes

2 of 15

No

No

2 of 15

No

No

1 of 15

No

No

1

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

Yes

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

Rattus norvegicus (Norway rat) (7)

8 of 13

Yes

Yes

5 of 13

No

Yes

Rnor\RGD1560248

5 of 13

No

Yes

1 of 13

No

No

1 of 13

No

No

1 of 13

No

Yes

1 of 13

No

Yes

Xenopus tropicalis (Western clawed frog) (6)

10 of 12

Yes

Yes

8 of 12

No

Yes

3 of 12

No

Yes

1 of 12

No

No

1 of 12

No

No

1 of 12

No

Yes

Danio rerio (Zebrafish) (17)

12 of 15

Yes

Yes

10 of 15

No

Yes

10 of 15

No

Yes

9 of 15

No

Yes

5 of 15

No

Yes

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

Yes

1 of 15

No

No

1 of 15

No

No

Drer\LOC101882228

1 of 15

No

No

Drer\LOC103909278

1 of 15

No

Yes

1 of 15

No

No

Drer\si:dkey-280e21.3

1 of 15

No

No

Caenorhabditis elegans (Nematode, roundworm) (5)

14 of 15

Yes

Yes

4 of 15

No

Yes

1 of 15

No

No

1 of 15

No

No

1 of 15

No

Yes

Arabidopsis thaliana (thale-cress) (11)

1 of 9

Yes

No

1 of 9

Yes

No

1 of 9

Yes

No

1 of 9

Yes

No

1 of 9

Yes

No

1 of 9

Yes

No

1 of 9

Yes

No

1 of 9

Yes

No

1 of 9

Yes

No

1 of 9

Yes

No

1 of 9

Yes

No

Saccharomyces cerevisiae (Brewer's yeast) (2)

5 of 15

Yes

Yes

5 of 15

Yes

No

Schizosaccharomyces pombe (Fission yeast) (3)

2 of 12

Yes

No

2 of 12

Yes

No

2 of 12

Yes

No

Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG091901L5 )

Organism

Common Name

Gene

AAA Syntenic Ortholog

Multiple Dmel Genes in this Orthologous Group

Drosophila suzukii

Spotted wing Drosophila

Dsuz\DS10_00004036

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Drosophila persimilis

Drosophila willistoni

Drosophila virilis

Drosophila mojavensis

Drosophila grimshawi

Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG0915018L )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Musca domestica

House fly

Glossina morsitans

Tsetse fly

Gmor\GMOY011068

Lucilia cuprina

Australian sheep blowfly

Lcup\FF38_05772

Mayetiola destructor

Hessian fly

Mdes\Mdes008240

Aedes aegypti

Yellow fever mosquito

Aaeg\AAEL009371

Anopheles darlingi

American malaria mosquito

Adar\ADAC004242

Anopheles gambiae

Malaria mosquito

Agam\AGAP004805

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ004254

Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W011J )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Bombyx mori

Silkmoth

Bmor\BGIBMGA009881

Danaus plexippus

Monarch butterfly

Dple\DPOGS200828-PA

Danaus plexippus

Monarch butterfly

Dple\DPOGS200827-PA

Heliconius melpomene

Postman butterfly

Hmel\HMEL011471

Apis florea

Little honeybee

Aflo\2147541523

Apis mellifera

Western honey bee

Bombus impatiens

Common eastern bumble bee

Bombus terrestris

Buff-tailed bumblebee

Linepithema humile

Argentine ant

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:0018df

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG021278

Dendroctonus ponderosae

Mountain pine beetle

Tribolium castaneum

Red flour beetle

Pediculus humanus

Human body louse

Phum\PHUM257720

Rhodnius prolixus

Kissing bug

Rpro\RPRC010745

Cimex lectularius

Bed bug

Clec\CLEC000603

Cimex lectularius

Bed bug

Clec\CLEC000602

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI009955

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_01366

Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X00ZQ )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strigamia maritima

European centipede

Smar\SMAR011666

Ixodes scapularis

Black-legged tick

Isca\ISCW017809

Stegodyphus mimosarum

African social velvet spider

Smim\KFM72106.1

Tetranychus urticae

Two-spotted spider mite

Turt\tetur04g05020

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_305626

Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G01GP )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-FormL2iB

Ciona intestinalis

Vase tunicate

Cint\ENSCING00000003656

Gallus gallus

Domestic chicken

Ggal\ENSGALG00000000694

Gallus gallus

Domestic chicken

Ggal\ENSGALG00000012525

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v8.0)

Drosophila melanogaster (Fruit fly) (5)

Gene Symbol

Score

Source

Alignment

4 of 10

3 of 10

3 of 10

2 of 10

1 of 10

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

FMNL1; formin like 1

13 of 15

FMNL3; formin like 3

13 of 15

FMNL2; formin like 2

11 of 15

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

View in Interactions Browser

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

pull down, autoradiography

(Dollar et al., 2016)

experimental knowledge based

(Guruharsha et al., 2011)

experimental knowledge based

(Guruharsha et al., 2011)

experimental knowledge based

(Guruharsha et al., 2011)

experimental knowledge based

(Guruharsha et al., 2011)

experimental knowledge based

(Guruharsha et al., 2011)

pull down, autoradiography

(Dollar et al., 2016)

experimental knowledge based

(Guruharsha et al., 2011)

experimental knowledge based

(Guruharsha et al., 2011)

experimental knowledge based

(Guruharsha et al., 2011)

pull down, autoradiography

(Dollar et al., 2016)

experimental knowledge based

(Guruharsha et al., 2011)

experimental knowledge based

(Guruharsha et al., 2011)

pull down, autoradiography, anti tag coimmunoprecipitation, anti tag western blot

(Dollar et al., 2016)

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

experimental knowledge based

(Guruharsha et al., 2011)

experimental knowledge based

(Guruharsha et al., 2011)

Summary of Genetic Interactions

esyN Network Diagram

esyN Network Key:

Suppression

Enhancement

View in Interactions Browser

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

suppressible

(Dollar et al., 2016)

enhanceable

(Dollar et al., 2016)

enhanceable

(Dollar et al., 2016)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

enhanceable

(Dollar et al., 2016)

suppressible

(Dollar et al., 2016)

enhanceable

(Dollar et al., 2016)

enhanceable

(Buff et al., 2007)

enhanceable

(Dollar et al., 2016)

External Data

Subunit Structure (UniProtKB)

Self-associates. Interacts (via GBD/FH3 domain) with Cdc42; the interaction is stronger with the GTP bound form of Cdc42.

(UniProt, Q9VUC6 )

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0267795

MIST (genetic) - An integrated Molecular Interaction Database

Frl

MIST (protein-protein) - An integrated Molecular Interaction Database

Frl

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0267795

External Data

Linkouts

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

RHO GTPases Activate Formins

Genomic Location and Detailed Mapping Data

Chromosome (arm)

3L

Recombination map

3-42

Cytogenetic map

Sequence location

3L:14,053,215..14,071,583 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

70D1-70D1

Limits computationally determined from genome sequence between P{EP}EP3561^EP3561 and P{PZ}l(3)70Da⁰²⁴⁰²&P{PZ}btl⁰⁰²⁰⁸

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

3-42

(FlyBase, 2016)

3-35.6

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (11)

22007

w¹¹¹⁸; P{EPg}Frl^HP36775

65461

w¹¹¹⁸; PBac{IT.GAL4}Frl^1129-G4

37600

y¹ w^*; Mi{MIC}Frl^MI03375

15691

y¹ w^67c23; P{EPgy2}Frl^EY03931

17193

w¹¹¹⁸; P{EP}Frl^EP697/TM6B, Tb¹

32447

y¹ sc^* v¹ sev²¹; P{TRiP.HMS00445}attP2

60195

y¹ w^*; Mi{PT-GFSTF.0}Frl^{MI03375-GFSTF.0}/TM3, Sb¹ Ser¹

v110438

P{KK101703}VIE-260B

v34412

w¹¹¹⁸; P{GD10799}v34412

v34413

w¹¹¹⁸; P{GD10799}v34413

v318758

PBac{fTRG01118.sfGFP-TVPTBF}VK00002

Genomic Clones (10)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (38)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0267795

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

39561

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Other Information

Relationship to Other Genes

Source for database identify of

Source for identity of: Frl CG32138

(Dollar et al., 2016)

Source for database merge of

Source for merge of: CG13485 CG6807

(FlyBase Genome Annotators, 2002-2003)

Source for merge of: CG32138 CG43986

(FlyBase Genome Annotators, 2014)

Additional comments

Annotation CG32138 merged with CG43986 in release 6.02 of the genome annotation; CG43986 appears to be non-coding and to correspond to an alternative 5' UTR exon of CG32138.

(FlyBase Genome Annotators, 2014)

Annotations CG13485 and CG6807 merged as CG32138 in release 3 of the genome annotation.

(FlyBase Genome Annotators, 2002-2003)

Other Comments

New annotation (CG43986) in release 5.46 of the genome annotation.

(FlyBase Genome Annotators, 2012)

dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R⁺ cell morphology.

(Kiger et al., 2003)

Origin and Etymology

Discoverer

Etymology

Named 'Frl' as it is the sole representative of the Frl formin subfamily in flies.

(Dollar et al., 2016)

Identification

External Crossreferences and Linkouts ( 50 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

39561

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

Q9VUC6

Other crossreferences

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0267795

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0267795

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

39561/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0267795

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

CG32138_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0052138

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0267795

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG32138

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0267795

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

39561

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC034448

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

Dmel_CG32138

MARRVEL_MODEL - MARRVEL (model organism gene)

39561

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0267795

MIST (genetic) - An integrated Molecular Interaction Database

Frl

MIST (protein-protein) - An integrated Molecular Interaction Database

Frl

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

RHO GTPases Activate Formins

Synonyms and Secondary IDs (10)

Reported As

Symbol Synonym

CG13485

CG32138

(Clandinin and Owens, 2016-, Dollar et al., 2016, Sarov et al., 2016, Aradska et al., 2015, Gene Disruption Project members, 2015-, Hosono et al., 2015, Jones and Macdonald, 2015, FlyBase Genome Annotators, 2014, Gupta et al., 2014, Christis and Munro, 2012, Rohn et al., 2011, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Kwon et al., 2008, Sepp et al., 2008, Buff et al., 2007)

CG43986

(FlyBase Genome Annotators, 2012)

CG6807

(Tanaka et al., 2004, Goldstein and Gunawardena, 2000)

Frl

(Kapoor et al., 2021, Chougule et al., 2020, Ninova et al., 2020, FlyBase Genome Annotators, 2019-, Lee et al., 2018, Vu et al., 2018, Gene Disruption Project members, 2016-)

Q9VUC5_DROME

(Fukuyama et al., 2012)

Q9VUC6_DROME

(Fukuyama et al., 2012)

anon-WO0172774.98

frl

(Bischoff et al., 2021, Dehapiot et al., 2020, Pinheiro et al., 2017, Dollar et al., 2016)

Name Synonyms

Formin-like

Secondary FlyBase IDs

FBgn0052138
FBgn0036407
FBgn0036408
FBgn0046339
FBgn0264718

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

References (67)

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