FB2020_06, released Dec 22, 2020

Gene: Dmel\Syx7

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General Information
Symbol
Dmel\Syx7
Species
D. melanogaster
Name
Syntaxin 7
Annotation Symbol
CG5081
Feature Type
protein_coding_gene
FlyBase ID
FBgn0267849
Gene Model Status
Current
Stock Availability
9 publicly available
Gene Snapshot
Syntaxin 7 (Syx7) encodes a SNARE protein that is part of the core machinery (including the products of Rab5, Rbsn-5, and Vps45) by which endocytic cargo vesicles fuse with the early endosome. [Date last reviewed: 2019-03-14]
Other Summaries
Also Known As

Avl, Avalanche, braided, Syntaxin, STX7

Key Links
Genomic Location
Cytogenetic map
78D2-78D2
Sequence location
3L:21,445,834..21,448,128 [+]
Recombination map

3-47

RefSeq locus
NT_037436 REGION:21445834..21448128
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (23 terms)
Molecular Function (3 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
enables protein binding
inferred from physical interaction with FLYBASE:Vps33B; FB:FBgn0039335
(Akbar et al., 2009)
inferred from physical interaction with FLYBASE:Vps45; FB:FBgn0261049
(Morrison et al., 2008)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
enables SNAP receptor activity
inferred from biological aspect of ancestor with PANTHER:PTN000461349
(assigned by GO_Central )
(Gaudet et al., 2011)
inferred from sequence or structural similarity
(Littleton, 2000)
non-traceable author statement
(Littleton et al., 1999)
enables SNARE binding
inferred from sequence or structural similarity with RGD:619747
(FlyBase Curators, 2008--)
inferred from biological aspect of ancestor with PANTHER:PTN000461349
(assigned by GO_Central )
(Gaudet et al., 2011)
Biological Process (14 terms)
Terms Based on Experimental Evidence (8 terms)
CV Term
Evidence
References
involved_in endosomal vesicle fusion
inferred from mutant phenotype
(Morrison et al., 2008)
involved_in establishment or maintenance of apical/basal cell polarity
inferred from mutant phenotype
(Lu and Bilder, 2005)
involved_in multicellular organism growth
inferred from mutant phenotype
(Colombani et al., 2012)
involved_in negative regulation of cell population proliferation
inferred from mutant phenotype
(Lu and Bilder, 2005)
involved_in negative regulation of imaginal disc growth
inferred from mutant phenotype
(Gerlach et al., 2018)
involved_in plasma membrane to endosome transport
inferred from mutant phenotype
(Morrison et al., 2008)
involved_in positive regulation of endocytosis
inferred from mutant phenotype
(Lu and Bilder, 2005)
involved_in pupariation
inferred from mutant phenotype
(Colombani et al., 2012)
Terms Based on Predictions or Assertions (6 terms)
CV Term
Evidence
References
involved_in intracellular protein transport
inferred from biological aspect of ancestor with PANTHER:PTN000461349
(assigned by GO_Central )
(Gaudet et al., 2011)
involved_in neurotransmitter secretion
non-traceable author statement
(Lloyd et al., 2000)
involved_in synaptic vesicle docking
inferred from sequence or structural similarity
(Littleton, 2000)
involved_in vesicle docking
inferred from biological aspect of ancestor with PANTHER:PTN000461349
(assigned by GO_Central )
(Gaudet et al., 2011)
involved_in vesicle fusion
inferred from biological aspect of ancestor with PANTHER:PTN000461349
(assigned by GO_Central )
(Gaudet et al., 2011)
inferred from sequence or structural similarity with RGD:619747
(FlyBase Curators, 2008--)
involved_in vesicle-mediated transport
non-traceable author statement
(Lloyd et al., 2000)
Cellular Component (6 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
located_in early endosome
inferred from direct assay
(Morrison et al., 2008, Lu and Bilder, 2005)
Terms Based on Predictions or Assertions (5 terms)
CV Term
Evidence
References
located_in endomembrane system
inferred from biological aspect of ancestor with PANTHER:PTN000461349
(assigned by GO_Central )
(Gaudet et al., 2011)
located_in integral component of membrane
inferred from biological aspect of ancestor with PANTHER:PTN000461349
(assigned by GO_Central )
(Gaudet et al., 2011)
located_in plasma membrane
non-traceable author statement
(Littleton et al., 1999)
inferred from sequence or structural similarity
(Littleton, 2000)
part_of SNARE complex
inferred from biological aspect of ancestor with PANTHER:PTN000461349
(assigned by GO_Central )
(Gaudet et al., 2011)
inferred from sequence or structural similarity with RGD:619747
(FlyBase Curators, 2008--)
located_in synaptic vesicle
inferred from biological aspect of ancestor with PANTHER:PTN000751604
(assigned by GO_Central )
(Gaudet et al., 2011)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Group (FlyBase)
Qa-SNAREs -
Q-SNAREs are members of the SNARE (soluble N-ethylmaleimide-sensitive factor-attachment protein (SNAP) receptor) family that mediate vesicle-fusion. SNAREs are cytoplasmic, membrane-anchored proteins that contain a 60 amino acid SNARE domain. Three Q-SNAREs domains from the target membrane and one R-SNARE domain from the vesicle interact to form a four four-helix bundle that pulls the two membranes in close proximity and promotes fusion. After fusion, the complexes are dissembled by NSF (N-ethylmaleimide-sensitive factor) and SNAPs (Soluble NSF Attachment Proteins). Q-SNAREs are named from their contribution of a conserved glutamine (Q) residue to the helix bundle. Q-SNARE domains are designated a, b or c, depending on their position within the helix bundle. (Adapted from PMID:15893389 and FBrf0216182).
Gene Model and Products
Number of Transcripts
2
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\Syx7 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.45

Sequence Ontology: Class of Gene
gene
(Ghabrial et al., 2011)
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Syx7-RA
FBtr0078351
NM_168905
1573
282
Syx7-RB
FBtr0078352
NM_168906
1610
282
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
Syx7-PA
FBpp0078007
31.8
282
6.81
NP_730632
AAF51725
Syx7-PB
FBpp0078008
31.8
282
6.81
NP_730633
AAF51726
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

282 aa isoforms: Syx7-PA, Syx7-PB
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Syx7 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
third instar larval stage
cell
(Yuva-Aydemir et al., 2011)
larval stage
embryonic/larval hemocyte
(Rahman et al., 2012)
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
western blot
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
organism
(Rahman et al., 2012)
Additional Descriptive Data

Syx7 protein is localized to early phagosomes in hemocytes.

(Rahman et al., 2012)
Marker for
 
early endosome
(Yuva-Aydemir et al., 2011, Vaccari et al., 2010)
Subcellular Localization
CV Term
Evidence
References
located_in early endosome
inferred from direct assay
(Morrison et al., 2008, Lu and Bilder, 2005)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Syx7 in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 8 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 7 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Syx7
Transgenic constructs containing regulatory region of Syx7
Deletions and Duplications ( 1 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal, with Scer\GAL4Mef2.PR
lethal | somatic clone
lethal - all die before end of first instar larval stage | recessive
lethal - all die before end of pupal stage, with Scer\GAL4en-e16E
lethal - all die before end of pupal stage, with Scer\GAL4pnr-MD237
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4tin.CΔ4
Sterility
Allele
female sterile germline-dependent
Other Phenotypes
Allele
cell polarity defective, with Scer\GAL4en-e16E
cell polarity defective | somatic clone
cell shape defective | somatic clone
developmental rate defective, with Scer\GAL4rn.PU
developmental rate defective | somatic clone
hyperplasia, with Scer\GAL4en-e16E
hyperplasia | somatic clone
large body, with Scer\GAL4rn-GAL4-5
large body | larval stage | somatic clone
neoplasia, with Scer\GAL4rn-GAL4-5
some die during first instar larval stage | recessive
some die during pupal stage, with Scer\GAL4en-e16E
some die during pupal stage, with Scer\GAL4pnr-MD237
tumorigenic | somatic clone
Phenotype manifest in
Allele
early endosome | somatic clone
embryonic/larval tracheal system
epithelium, with Scer\GAL4NP1624
eye | somatic clone
eye-antennal disc & cell & adherens junction | ectopic | somatic clone
eye-antennal disc | somatic clone
eye disc | somatic clone
female germline cyst, with Scer\GAL4NP1624
follicle cell | somatic clone
imaginal disc, with Scer\GAL4rn-GAL4-5
terminal tracheal cell
terminal tracheal cell | somatic clone
wing disc, with Scer\GAL4rn-GAL4-5
wing disc posterior compartment, with Scer\GAL4en-e16E
yolk granule | germline clone
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (5)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\STX7
14 of 15
Yes
Yes
Hsap\STX12
12 of 15
No
Yes
Hsap\STX16
2 of 15
No
No
Hsap\TSNARE1
2 of 15
No
No
Hsap\STX17
1 of 15
No
No
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (4)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Stx7
14 of 15
Yes
Yes
Mmus\Stx12
12 of 15
No
Yes
Mmus\Stx16
2 of 15
No
No
Mmus\Stx17
1 of 15
No
No
Rattus norvegicus (Norway rat) (5)
Rnor\Stx7
13 of 13
Yes
Yes
Rnor\Stx12
12 of 13
No
Yes
Rnor\LOC100910446
7 of 13
No
Yes
Rnor\Stx16
1 of 13
No
No
Rnor\Stx17
1 of 13
No
No
Xenopus tropicalis (Western clawed frog) (4)
Xtro\stx7
13 of 12
Yes
Yes
Xtro\stx12
8 of 12
No
Yes
Xtro\tsnare1
3 of 12
No
No
Xtro\stx16
2 of 12
No
No
Danio rerio (Zebrafish) (6)
Drer\stx12
13 of 15
Yes
Yes
Drer\stx12l
12 of 15
No
Yes
Drer\stx7l
10 of 15
No
Yes
Drer\si:ch211-208k15.1
2 of 15
No
No
Drer\stx16
2 of 15
No
No
Drer\stx17
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (3)
Cele\syx-7
12 of 15
Yes
Yes
Cele\syx-17
4 of 15
No
Yes
Cele\syx-16
2 of 15
No
No
Arabidopsis thaliana (thale-cress) (4)
Atha\VAM3
9 of 9
Yes
Yes
Atha\SYP21
8 of 9
No
Yes
Atha\SYP23
8 of 9
No
Yes
Atha\ATSYP24
5 of 9
No
Yes
Saccharomyces cerevisiae (Brewer's yeast) (3)
Scer\PEP12
10 of 15
Yes
Yes
Scer\VAM3
4 of 15
No
No
Scer\TLG2
3 of 15
No
No
Schizosaccharomyces pombe (Fission yeast) (2)
Spom\pep12
9 of 12
Yes
Yes
Spom\tlg2
1 of 12
No
No
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG09190FQT )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00004235
Drosophila simulans
Dsim\GD14962
Drosophila sechellia
Dsec\GM22370
Drosophila erecta
Dere\GG16188
Drosophila yakuba
Dyak\GE28680
Drosophila yakuba
Dyak\GE19759
Drosophila ananassae
Dana\GF10875
Drosophila pseudoobscura pseudoobscura
Dpse\GA18647
Drosophila persimilis
Dper\GL15057
Drosophila willistoni
Dwil\GK17194
Drosophila virilis
Dvir\GJ12254
Drosophila mojavensis
Dmoj\GI12362
Drosophila grimshawi
Dgri\GH16098
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091509YY )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17007061
Glossina morsitans
Tsetse fly
Gmor\GMOY005380
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_05598
Mayetiola destructor
Hessian fly
Mdes\Mdes000752
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL007731
Anopheles gambiae
Malaria mosquito
Agam\AGAP005543
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ015399
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ016059
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0CPS )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA000617
Danaus plexippus
Monarch butterfly
Dple\DPOGS206799-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL013048
Apis florea
Little honeybee
Aflo\2533445636
Apis mellifera
Western honey bee
Amel\Syx7
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP23149
Bombus terrestris
Buff-tailed bumblebee
Bter\15209387
Linepithema humile
Argentine ant
Lhum\LH21053
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:000e27
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG015050
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_04958
Tribolium castaneum
Red flour beetle
Tcas\TC032389
Pediculus humanus
Human body louse
Phum\PHUM582100
Rhodnius prolixus
Kissing bug
Rpro\RPRC009818
Cimex lectularius
Bed bug
Clec\CLEC000395
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI001495
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_08624
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0CNP )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR000186
Ixodes scapularis
Black-legged tick
Isca\ISCW014129
Stegodyphus mimosarum
African social velvet spider
Smim\KFM61469.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur19g00580
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_195372
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0HKZ )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\SPU_017779gn
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Stx12
Ciona intestinalis
Vase tunicate
Cint\LOC100179377
Ciona intestinalis
Vase tunicate
Cint\LOC100184777
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000016161
Gallus gallus
Domestic chicken
Ggal\STX7
Gallus gallus
Domestic chicken
Ggal\STX12
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (8)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
Syx13
7 of 10
Syx16
4 of 10
Syx17
3 of 10
Syx1A
2 of 10
Syx4
2 of 10
Syx5
2 of 10
Syx6
1 of 10
Syx8
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
Disease Model Summary Ribbon
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 1 )
Allele
Disease
Evidence
References
Syx71
model of  carcinoma
CEA
(Lu and Bilder, 2005)
Potential Models Based on Orthology ( 0 )
Human Ortholog
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 2 )
Allele
Disease
Interaction
References
Syx71
model of  carcinoma
is ameliorated by Syx7hs.PL
(Lu and Bilder, 2005)
Syx7hs.PL
ameliorates  carcinoma
modeled by Syx71
(Lu and Bilder, 2005)
Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Homo sapiens (Human)
Gene name
Score
OMIM
OMIM Phenotype
DO term
Complementation?
Transgene?
STX7; syntaxin 7
14 of 15
603217
      STX12; syntaxin 12
      12 of 15
      606892
          Functional Complementation Data
          Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
          Interactions
          Summary of Physical Interactions
          esyN Network Diagram
          Show neighbor-neighbor interactions:
          Select Layout:
          Legend:
          Protein
          RNA
          Selected Interactor(s)
          Interactions Browser
          View in Interactions Browser
          Please see the Physical Interaction reports below for full details
          protein-protein
          Physical Interaction
          Assay
          References
          Syx7 - AttD
          experimental knowledge based
          (Guruharsha et al., 2011)
          Syx7 - Bet1
          experimental knowledge based
          (Guruharsha et al., 2011)
          Syx7 - CG14767
          experimental knowledge based
          (Guruharsha et al., 2011)
          Syx7 - CG15098
          experimental knowledge based
          (Guruharsha et al., 2011)
          Syx7 - CG3164
          experimental knowledge based
          (Guruharsha et al., 2011)
          Syx7 - CG7668
          experimental knowledge based
          (Guruharsha et al., 2011)
          Syx7 - Frl
          experimental knowledge based
          (Guruharsha et al., 2011)
          Syx7 - Gos28
          experimental knowledge based
          (Guruharsha et al., 2011)
          Syx7 - Membrin
          experimental knowledge based
          (Guruharsha et al., 2011)
          Syx7 - Past1
          experimental knowledge based
          (Guruharsha et al., 2011)
          Syx7 - Pvr
          experimental knowledge based
          (Guruharsha et al., 2011)
          Syx7 - Sec20
          experimental knowledge based
          (Guruharsha et al., 2011)
          Syx7 - Sec22
          experimental knowledge based
          (Guruharsha et al., 2011)
          Syx7 - Slh
          experimental knowledge based
          (Guruharsha et al., 2011)
          Syx7 - Snap24
          experimental knowledge based
          (Guruharsha et al., 2011)
          Syx7 - Snap25
          experimental knowledge based
          (Guruharsha et al., 2011)
          Syx7 - Snap29
          experimental knowledge based, anti bait coimmunoprecipitation, peptide massfingerprinting
          (Morelli et al., 2014, Guruharsha et al., 2011)
          Syx7 - Syb
          experimental knowledge based
          (Guruharsha et al., 2011)
          Syx7 - Syx13
          experimental knowledge based
          (Guruharsha et al., 2011)
          Syx7 - Syx16
          experimental knowledge based
          (Guruharsha et al., 2011)
          Syx7 - Syx18
          experimental knowledge based
          (Guruharsha et al., 2011)
          Syx7 - Syx1A
          experimental knowledge based
          (Guruharsha et al., 2011)
          Syx7 - Syx4
          experimental knowledge based
          (Guruharsha et al., 2011)
          Syx7 - Syx5
          experimental knowledge based
          (Guruharsha et al., 2011)
          Syx7 - Syx8
          experimental knowledge based
          (Guruharsha et al., 2011)
          Syx7 - Use1
          experimental knowledge based
          (Guruharsha et al., 2011)
          Syx7 - Vamp7
          experimental knowledge based
          (Guruharsha et al., 2011)
          Syx7 - Vha100-1
          pull down, western blot, anti bait coimmunoprecipitation
          (Williamson et al., 2010)
          Syx7 - Vps33B
          anti bait coimmunoprecipitation, anti tag western blot
          (Akbar et al., 2009)
          Syx7 - Vps45
          pull down, anti tag western blot
          (Morrison et al., 2008)
          Syx7 - Ykt6
          experimental knowledge based
          (Guruharsha et al., 2011)
          Syx7 - fax
          experimental knowledge based
          (Guruharsha et al., 2011)
          Syx7 - koko
          experimental knowledge based
          (Guruharsha et al., 2011)
          Syx7 - αSnap
          experimental knowledge based
          (Guruharsha et al., 2011)
          Syx7 - γSnap1
          experimental knowledge based
          (Guruharsha et al., 2011)
          Syx7 - γSnap2
          experimental knowledge based
          (Guruharsha et al., 2011)
          Summary of Genetic Interactions
          esyN Network Diagram
          esyN Network Key:
          Suppression
          Enhancement
          View in Interactions Browser
          Please look at the allele data for full details of the genetic interactions
          Starting gene(s)
          Interaction type
          Interacting gene(s)
          Reference
          Syx7
          suppressible
          aPKC
          (Lu and Bilder, 2005)
          Syx7
          suppressible
          ben
          (Andersen et al., 2015)
          Syx7
          suppressible
          bsk
          (Andersen et al., 2015)
          Syx7
          suppressible
          grnd
          (Andersen et al., 2015)
          Syx7
          suppressible
          hep
          (Andersen et al., 2015)
          Syx7
          suppressible
          Ilp8
          (Colombani et al., 2012)
          Syx7
          suppressible
          Moe
          (Schottenfeld-Roames et al., 2014)
          Syx7
          suppressible
          puc
          (Colombani et al., 2012)
          Syx7
          suppressible
          sd
          (Boone et al., 2016)
          Syx7
          suppressible
          Tab2
          (Andersen et al., 2015)
          Syx7
          suppressible
          Tak1
          (Andersen et al., 2015)
          Syx7
          suppressible
          yki
          (Boone et al., 2016)
          Starting gene(s)
          Interaction type
          Interacting gene(s)
          Reference
          External Data
          Linkouts
          MIST (protein-protein) - An integrated Molecular Interaction Database
          Pathways
          Signaling Pathways (FlyBase)
          Metabolic Pathways
          External Data
          Linkouts
          KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
          Genomic Location and Detailed Mapping Data
          Chromosome (arm)
          3L
          Recombination map

          3-47

          Cytogenetic map
          78D2-78D2
          Sequence location
          3L:21,445,834..21,448,128 [+]
          FlyBase Computed Cytological Location
          Cytogenetic map
          Evidence for location
          78D2-78D2
          Limits computationally determined from genome sequence between P{lacW}l(3)j1B10j1B10 and P{lacW}l(3)j2C4j2C4
          Experimentally Determined Cytological Location
          Cytogenetic map
          Notes
          References
          78D-78E
          (Lu and Bilder, 2005)
          Meiotic recombination and chromosomal deficiencies were used to map Syx71.
          (Lu and Bilder, 2005)
          Experimentally Determined Recombination Data
          Location

          3-47

          (FlyBase, 2016)

          3-43.8

          (Comeron et al., 2012)

          3-

          (Ghabrial et al., 2011)
          Left of (cM)
          Right of (cM)
          Notes

          Maps to 3L.

          (Ghabrial et al., 2011)
          Stocks and Reagents
          Stocks (9)
          Genomic Clones (17)
           

          Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

          cDNA Clones (102)
           

          Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

          cDNA clones, fully sequenced
          BDGP DGC clones
          Other clones
          Drosophila Genomics Resource Center cDNA clones

          For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

          cDNA Clones, End Sequenced (ESTs)
          BDGP DGC clones
          Other clones
          RNAi and Array Information
          Linkouts
          GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
          Antibody Information
          Laboratory Generated Antibodies
           
          Commercially Available Antibodies
           
          Other Information
          Relationship to Other Genes
          Source for database identify of

          Source for identity of: Syx7 CG5081

          (McLennan, 2001.5.22)
          Source for database merge of

          Source for merge of: Syx7 avl

          (Lu and Bilder, 2005)

          Source for merge of: Syx7 braided

          (Schottenfeld-Roames et al., 2014)
          Additional comments
          Other Comments

          avl is involved in endocytic trafficking.

          (Bilder and Lu, 2005)

          avl mutant tissues form tumour-like growths. Loss of function avl mutants cause columnar monolayered epithelia to become rounded and mulitlayered and to have apical proteins and adherens junctions ectopically localized throughout the basolateral surface.

          (Bilder and Lu, 2005)

          Ovarian follicular cells are rounded and form a multilayered structure in mutant females (in contrast to the monolayer of columnar-shaped follicle cells found in the wild type). Eye discs consisting mostly of avl mutant cells show massive overproliferation, resulting in tumour-like growths. Mutant cells ectopically localize apical proteins as well as adherens junctions throughout the basolateral cell surface.

          (Lu and Bilder, 2005)

          dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.

          (Kiger et al., 2003)
          Origin and Etymology
          Discoverer
          Etymology
          Identification
          External Crossreferences and Linkouts ( 25 )
          Sequence Crossreferences
          NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
          GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
          GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
          RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
          UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
          Other crossreferences
          Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
          Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
          Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
          GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
          iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
          InterPro - A database of protein families, domains and functional sites
          KEGG Genes - Molecular building blocks of life in the genomic space.
          Linkouts
          KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
          MIST (protein-protein) - An integrated Molecular Interaction Database
          Synonyms and Secondary IDs (25)
          Reported As
          Symbol Synonym
          Aval
          (Xu et al., 2011)
          Avl
          (Vaufrey et al., 2018, Amoyel and Bach, 2014, Sakuma et al., 2014, Tognon et al., 2014, Wang et al., 2014, Gailite et al., 2012, Li et al., 2012, Rahman et al., 2012, Akbar et al., 2011, Yuva-Aydemir et al., 2011, Haberman et al., 2010, Vaccari et al., 2010, Williamson et al., 2010, Windler and Bilder, 2010, Akbar et al., 2009, Demontis and Dahmann, 2009, Nagaraj and Banerjee, 2009, Harris and Tepass, 2008, Juhász et al., 2008, Kerman et al., 2008, Morrison et al., 2008, Vaccari et al., 2008, Giebel and Wodarz, 2006, Jaekel and Klein, 2006)
          CG5081
          (Laffafian and Tepass, 2019, Harris et al., 2016, Hosono et al., 2015, Yano et al., 2012, Keleman et al., 2009.8.5, Perkins et al., 2009, Lu and Bilder, 2005)
          Dm Syx7
          (Littleton, 2000)
          DmSyx7
          (McLennan, 2001.5.22)
          FCP-C
          (Horne-Badovinac et al., 2012)
          STX7
          (Gordon et al., 2017, Roman-Fernandez and Bryant, 2016)
          SYX7
          (Lloyd et al., 2000)
          Syx
          (Wagh et al., 2006)
          Syx7
          (Laffafian and Tepass, 2019, Meltzer et al., 2019, Transgenic RNAi Project members, 2017-, Liu et al., 2014, Morelli et al., 2014, Schottenfeld-Roames et al., 2014, Kwon et al., 2013, Haberman et al., 2012, Japanese National Institute of Genetics, 2012.5.21, Haberman et al., 2010, Williamson et al., 2010, Williamson et al., 2010, Kloepper et al., 2008, Kloepper et al., 2008, Lagow et al., 2007, Stuart et al., 2007)
          avl
          (Liao and Nässel, 2020, Cong et al., 2018, Gerlach et al., 2018, Tang et al., 2017, Yamamoto et al., 2017, Boone et al., 2016, Andersen et al., 2015, Schottenfeld-Roames et al., 2014, Zhang et al., 2014, Colombani et al., 2012, Horne-Badovinac et al., 2012, Vaccari et al., 2009, Morrison et al., 2008, Vaccari et al., 2008, Menut et al., 2007, Tountas and Fortini, 2007, Budde, 2005, Lu and Bilder, 2005, Vaccari and Bilder, 2005)
          braided
          dSyn7
          (Pulipparacharuvil et al., 2005)
          syx7
          (González-Méndez et al., 2020, Sandmann et al., 2007)
          syx7/avl
          (Gilbert et al., 2009)
          Name Synonyms
          Avalanche
          (Amoyel and Bach, 2014, Wang et al., 2014, Gailite et al., 2012, Li et al., 2012, Akbar et al., 2011, Yuva-Aydemir et al., 2011, Demontis and Dahmann, 2009, Nagaraj and Banerjee, 2009, Harris and Tepass, 2008, Vaccari et al., 2008, Akbar et al., 2007, Jaekel and Klein, 2006)
          Syntaxin
          (Hossain et al., 2008, Kittel et al., 2006, Pereanu and Hartenstein, 2006, Wagh et al., 2006)
          Syntaxin 7
          (Saadin and Starz-Gaiano, 2018, Harris et al., 2016, Yano et al., 2012, McLennan, 2001.5.22)
          Syntaxin7
          (Schottenfeld-Roames et al., 2014, Suprabha et al., 2003)
          avalanche
          (Cong et al., 2018, Vaufrey et al., 2018, Andersen et al., 2015, Schottenfeld-Roames et al., 2014, Vaccari et al., 2009, Tountas and Fortini, 2007, Solecki et al., 2006, Lu and Bilder, 2005, Lu and Bilder, 2005)
          braided
          (Schottenfeld-Roames et al., 2014, Ghabrial et al., 2011)
          dSyntaxin-7
          (Pulipparacharuvil et al., 2005)
          synatxin7/avalanche
          (Gilbert et al., 2009)
          syntaxin
          (Dumstrei et al., 2003)
          syntaxin 7
          (Mukherjee et al., 2020)
          syntaxin-7
          (Cong et al., 2018)
          Secondary FlyBase IDs
          • FBgn0264632
          • FBgn0086377
          • FBgn0033583
          • FBgn0082601
          Datasets (0)
          Study focus (0)
          Experimental Role
          Project
          Project Type
          Title
          References (115)