FlyBase Gene Report: Dmel\CanA-14F

General Information

Symbol

Dmel\CanA-14F

Species

D. melanogaster

Name

Calcineurin A at 14F

Annotation Symbol

CG9819

Feature Type

protein_coding_gene

FlyBase ID

FBgn0267912

Gene Model Status

Current

Stock Availability

8 publicly available

Gene Snapshot

Contributions welcome

Other Summaries

Alliance
Auto summary
Gene Group
UniProtKB
Interactive Fly

Also Known As

MRE12, Calcineurin

Key Links

Genomic Location

Cytogenetic map

14E3-14F1

Sequence location

X:16,560,684..16,587,172 [-]

Recombination map

1-54

RefSeq locus

NC_004354 REGION:16560684..16587172

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse GBrowse

Help me choose

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

Gene Ontology (GO) Annotations (8 terms)

Molecular Function (4 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

enables calmodulin-dependent protein phosphatase activity

inferred from mutant phenotype

(assigned by UniProt )

(Takeo et al., 2006)

enables protein binding

inferred from physical interaction with UniProtKB:Q9XZL8

(assigned by UniProt )

(Takeo et al., 2012, Takeo et al., 2006)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

enables calmodulin binding

inferred from biological aspect of ancestor with PANTHER:PTN000746105

(assigned by GO_Central )

(Gaudet et al., 2011)

enables calmodulin-dependent protein phosphatase activity

inferred from biological aspect of ancestor with PANTHER:PTN000746105

(assigned by GO_Central )

(Gaudet et al., 2011)

enables protein serine/threonine phosphatase activity

inferred from sequence or structural similarity

(Chen et al., 1992)

Biological Process (2 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

involved_in sleep

inferred from direct assay

(Nakai et al., 2011, Tomita et al., 2011)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

involved_in calcineurin-mediated signaling

inferred from biological aspect of ancestor with PANTHER:PTN000746105

(assigned by GO_Central )

(Gaudet et al., 2011)

Cellular Component (2 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

part_of calcineurin complex

inferred from biological aspect of ancestor with PANTHER:PTN000746105

(assigned by GO_Central )

(Gaudet et al., 2011)

located_in cytoplasm

inferred from biological aspect of ancestor with PANTHER:PTN000746105

(assigned by GO_Central )

(Gaudet et al., 2011)

Gene Group (FlyBase)

PPP FAMILY PROTEIN SERINE/THREONINE PHOSPHATASES

Protein Family (UniProt)

Belongs to the PPP phosphatase family. PP-2B subfamily. (Q9VXF1)

Protein Signatures (InterPro)

Summaries

Gene Group (FlyBase)

PPP FAMILY PROTEIN SERINE/THREONINE PHOSPHATASES -: The Phosphoprotein Phosphatase (PPP) family members are serine/threonine phosphatases. They often function in association with regulatory subunits. (Adapted from PMID:11230548 and PMID:19879837).

Protein Function (UniProtKB)

Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin.

(UniProt, Q9VXF1)

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\CanA-14F for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Comments on Gene Model

Gene model reviewed during 5.55

Gene model reviewed during 5.46

Gene model reviewed during 5.41

Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated

Sequence Ontology: Class of Gene

nuclear_gene

protein_coding_gene

retrotransposed_protein_coding_gene

(dos Santos, 2014, Miskei et al., 2011, Betran et al., 2002)

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

CanA-14F-RA

FBtr0074292

NM_167523

3052

584

CanA-14F-RB

FBtr0074293

NM_167524

6837

584

CanA-14F-RC

FBtr0305198

NM_001258788

7965

584

CanA-14F-RD

FBtr0332870

NM_001272693

4007

584

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

CanA-14F-PA

FBpp0074067

64.3

584

5.96

NP_727985

AAF48623

CanA-14F-PB

FBpp0074068

64.3

584

5.96

NP_727986

AAN09410

CanA-14F-PC

FBpp0293728

64.3

584

5.96

NP_001245717

AFH07430

CanA-14F-PD

FBpp0305092

64.3

584

5.96

NP_001259622

AGB95464

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

584 aa isoforms: CanA-14F-PA, CanA-14F-PB, CanA-14F-PC, CanA-14F-PD

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Subunit Structure (UniProtKB)

Interacts with sra in a complex that contains Pp2B-14D.

(UniProt, Q9VXF1)

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\CanA-14F using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Linkouts

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult optic lobe

(Tomita et al., 2011)

adult brain

(Tomita et al., 2011)

retina

(Tomita et al., 2011)

Additional Descriptive Data

CanA-14F is widely expressed in the adult brain, optic lobe, and retina.

(Tomita et al., 2011)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\CanA-14F in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\CanA-14F

View exonic expression by tissue for Dmel\CanA-14F

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG9819

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, and Transgenic Constructs

Classical and Insertion Alleles ( 6 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 10 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of CanA-14F

Transgenic constructs containing regulatory region of CanA-14F

Deletions and Duplications ( 0 )

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal, with Scer\GAL4^elav-C155

viable

CanA-14F^EY08594

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

CanA-14F^GD14690

viable, with Scer\GAL4^Mef2.PR

CanA-14F^GD14690

viable, with Scer\GAL4^pnr-MD237

CanA-14F^GD14690

viable, with Scer\GAL4^tin.CΔ4

CanA-14F^GD14690

Sterility

Allele

female semi-sterile, with Scer\GAL4^{VP16.mat.αTub67C}

CanA-14F^HMS01880

fertile

CanA-14F^EY08594

Other Phenotypes

Allele

hyperactive, with Scer\GAL4^elav-C155

CanA-14F^GD14690

hyperactive, with Scer\GAL4^elav-C155, Scer\GAL80^ts.αTub84B

CanA-14F^UAS.Tag:MYC

locomotor behavior defective

CanA-14F^KO

locomotor behavior defective, with Scer\GAL4^elav.PLu

CanA-14F^Act.UAS

sleep defective

CanA-14F^KO

sleep defective, with Scer\GAL4^elav.PLu

CanA-14F^Act.UAS

sleep defective, with Scer\GAL4^elav-C155

CanA-14F^GD14690

sleep defective | heat sensitive, with Scer\GAL4^elav-C155, Scer\GAL80^ts.αTub84B

Phenotype manifest in

Allele

mitochondrion | adult stage

CanA-14F^f02374

Orthologs

Downloads

Download All DIOPT Orthologs

Download All OrthoDB Orthologs

Human Orthologs (via DIOPT v8.0)

Homo sapiens (Human) (14)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Hsap\PPP3CA

13 of 15

Yes

Hsap\PPP3CB

12 of 15

Yes

Hsap\PPP3CC

12 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Yes

Hsap\PPP6C

1 of 15

Model Organism Orthologs (via DIOPT v8.0)

Mus musculus (laboratory mouse) (13)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Mmus\Ppp3cb

13 of 15

Yes

Mmus\Ppp3ca

12 of 15

Mmus\Ppp3cc

11 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Rattus norvegicus (Norway rat) (12)

Rnor\Ppp3ca

10 of 13

Yes

Rnor\Ppp3cc

9 of 13

Yes

Rnor\Ppp3cb

8 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Xenopus tropicalis (Western clawed frog) (12)

Xtro\ppp3ca

12 of 12

Yes

Xtro\ppp3cc

10 of 12

Yes

Xtro\ppp3cb

7 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Danio rerio (Zebrafish) (17)

Drer\ppp3ca

10 of 15

Yes

Drer\ppp3cca

10 of 15

Yes

Drer\ppp3ccb

10 of 15

Yes

Drer\ppp3cb

8 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Caenorhabditis elegans (Nematode, roundworm) (44)

Cele\tax-6

14 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Yes

Cele\ZK354.9

1 of 15

Cele\ZK938.1

1 of 15

Arabidopsis thaliana (thale-cress) (0)

No records found.

Saccharomyces cerevisiae (Brewer's yeast) (13)

Scer\CNA1

12 of 15

Yes

11 of 15

2 of 15

2 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Yes

Schizosaccharomyces pombe (Fission yeast) (1)

Spom\ppb1

11 of 12

Yes

Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG0919060Y )

Organism

Common Name

Gene

AAA Syntenic Ortholog

Multiple Dmel Genes in this Orthologous Group

Drosophila suzukii

Spotted wing Drosophila

Drosophila sechellia

Drosophila sechellia

Drosophila erecta

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Dpse\GA22069

Drosophila persimilis

Dper\GL19972

Drosophila willistoni

Dwil\GK25243

Drosophila willistoni

Dwil\GK25442

Drosophila virilis

Dvir\GJ19343

Drosophila mojavensis

Dmoj\GI15153

Drosophila mojavensis

Dmoj\GI15154

Drosophila grimshawi

Dgri\GH24890

Drosophila grimshawi

Dgri\GH24889

Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091503T8 )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Musca domestica

House fly

Mdoa\17011595

Musca domestica

House fly

Mdoa\17011777

Musca domestica

House fly

Mdoa\17018175

Glossina morsitans

Tsetse fly

Gmor\GMOY008907

Glossina morsitans

Tsetse fly

Gmor\GMOY008078

Glossina morsitans

Tsetse fly

Gmor\GMOY007597

Lucilia cuprina

Australian sheep blowfly

Lcup\FF38_10408

Lucilia cuprina

Australian sheep blowfly

Lcup\FF38_11822

Lucilia cuprina

Australian sheep blowfly

Lcup\FF38_02720

Mayetiola destructor

Hessian fly

Mdes\Mdes002974

Aedes aegypti

Yellow fever mosquito

Aaeg\AAEL008930

Anopheles darlingi

American malaria mosquito

Adar\ADAC008703

Anopheles gambiae

Malaria mosquito

Agam\AGAP001279

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ018692

Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W03LH )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Bombyx mori

Silkmoth

Bmor\cna

Danaus plexippus

Monarch butterfly

Dple\DPOGS206069-PA

Heliconius melpomene

Postman butterfly

Hmel\HMEL005036

Apis florea

Little honeybee

Aflo\2201296148

Apis mellifera

Western honey bee

Amel\LOC411046

Bombus impatiens

Common eastern bumble bee

Bimp\BIMP18082

Bombus terrestris

Buff-tailed bumblebee

Bter\15216049

Linepithema humile

Argentine ant

Lhum\LH25683

Linepithema humile

Argentine ant

Lhum\LH17508

Linepithema humile

Argentine ant

Lhum\LH17500

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:0011e2

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG007022

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG007393

Dendroctonus ponderosae

Mountain pine beetle

Dpod\YQE_09979

Dendroctonus ponderosae

Mountain pine beetle

Dpod\YQE_09950

Tribolium castaneum

Red flour beetle

Tcas\TC000103

Pediculus humanus

Human body louse

Phum\PHUM596230

Rhodnius prolixus

Kissing bug

Rpro\RPRC009380

Cimex lectularius

Bed bug

Clec\CLEC001543

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI003343

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_08435

Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X03IC )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Ixodes scapularis

Black-legged tick

Isca\ISCW024405

Stegodyphus mimosarum

African social velvet spider

Smim\KFM63371.1

Stegodyphus mimosarum

African social velvet spider

Smim\KFM80850.1

Tetranychus urticae

Two-spotted spider mite

Turt\tetur04g07540

Tetranychus urticae

Two-spotted spider mite

Turt\tetur04g07560

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_62512

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_312053

Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G094R )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Cn

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Cnbs

Ciona intestinalis

Vase tunicate

Cint\LOC100185597

Gallus gallus

Domestic chicken

Ggal\LOC769842

Gallus gallus

Domestic chicken

Ggal\PPP3CB

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v8.0)

Drosophila melanogaster (Fruit fly) (18)

Gene Symbol

Score

Source

Alignment

9 of 10

7 of 10

2 of 10

flw

2 of 10

mts

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

PpV

2 of 10

PpY-55A

2 of 10

rdgC

2 of 10

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 1 )

Human Ortholog

Disease

Evidence

References

PPP3CA; protein phosphatase 3 catalytic subunit alpha

model of infantile or early childhood epileptic encephalopathy 1

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

PPP3CA; protein phosphatase 3 catalytic subunit alpha

13 of 15

114105

infantile or early childhood epileptic encephalopathy 1

PPP3CB; protein phosphatase 3 catalytic subunit beta

12 of 15

114106

PPP3CC; protein phosphatase 3 catalytic subunit gamma

12 of 15

114107

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

View in Interactions Browser

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

CanA-14F - Cam

lambda phage display

(Xu et al., 1998)

CanA-14F - Pvr

anti tag coimmunoprecipitation, peptide massfingerprinting

(Friedman et al., 2011)

CanA-14F - dos

anti tag coimmunoprecipitation, peptide massfingerprinting

(Friedman et al., 2011)

CanA-14F - sra

anti tag coimmunoprecipitation, multidimensional protein identification technology, western blot

(Takeo et al., 2012)

Summary of Genetic Interactions

esyN Network Diagram

esyN Network Key:

Suppression

Enhancement

View in Interactions Browser

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

CanA-14F

enhanceable

sra

(Nakai et al., 2011)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

sra

suppressible

CanA-14F

(Nakai et al., 2011)

External Data

Subunit Structure (UniProtKB)

Interacts with sra in a complex that contains Pp2B-14D.

(UniProt, Q9VXF1 )

Linkouts

MIST (genetic) - An integrated Molecular Interaction Database

CanA-14F

MIST (protein-protein) - An integrated Molecular Interaction Database

CanA-14F

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

External Data

Linkouts

KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.

Wnt signaling pathway

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

1-54

Cytogenetic map

14E3-14F1

Sequence location

X:16,560,684..16,587,172 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

14E3-14F1

Limits computationally determined from genome sequence between P{EP}EP1547^EP1547 and P{EP}CG4928^EP1341

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

14D-14D

(Hong, 1995.6.28)

14D-14F

(determined by in situ hybridisation)

(Madueno et al., 1995)

Experimentally Determined Recombination Data

Location

1-54

(FlyBase, 2016)

1-55.5

(Comeron et al., 2012)

(Hong, 1995.6.28)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (8)

Bloomington

81693

y¹ v¹; P{TKO.GS03313}attP40

85641

w¹¹¹⁸ PBac{WH}CanA-14F^f02374

58249

y¹ v¹; P{TRiP.HMJ22270}attP40/CyO

61729

y¹ w^* Mi{MIC}CanA-14F^MI15488

17478

y¹ w^67c23 P{EPgy2}CanA-14F^EY08594

38966

y¹ sc^* v¹ sev²¹; P{TRiP.HMS01880}attP40

VDRC

v109858

P{KK110900}VIE-260B

v30105

w¹¹¹⁸; P{GD14690}v30105

Genomic Clones (14)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (21)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0267912

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

8674098

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Other Information

Relationship to Other Genes

Source for database identify of

Source for identity of: CanA-14F CG9819

(Sullivan and Rubin, 2002)

Source for database merge of

Source for merge of: CanA-14F MRE12

(FlyBase Genome Annotators, 2014)

Additional comments

MRE12 corresponds to a portion of the 3' UTR of CanA-14F.

(FlyBase Genome Annotators, 2014)

The CanA-14F gene may have been derived from a related phosphoprotein phosphatase gene by retroposition and subsequent tandem duplication.

(Miskei et al., 2011)

The CanA-14F gene may be derived from the CanA1 gene by retroposition.

(Betran et al., 2002)

Other Comments

Origin and Etymology

Discoverer

Etymology

Identification

External Crossreferences and Linkouts ( 62 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

8674098

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

Q9VXF1

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0267912

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG9819

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

8674098

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC000103

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

Dmel_CG9819

Linkouts

KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.

Wnt signaling pathway

MIST (genetic) - An integrated Molecular Interaction Database

CanA-14F

MIST (protein-protein) - An integrated Molecular Interaction Database

CanA-14F

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Synonyms and Secondary IDs (19)

Reported As

Symbol Synonym

CG9819

(Kanamori et al., 2013, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Wheeler et al., 2004, Betran et al., 2002, Sullivan and Rubin, 2002)

CaN

(Toprak et al., 2020)

CanA14F

(Zarndt et al., 2017)

CnnA14D

(Hong, 1995.6.28)

CnnA14D(I)

(Hong, 1995.6.29)

D27

(Chen et al., 1992)

DmCanA-14F

(Cohen et al., 2005)

MRE12

(Kageyama, 2007.2.28, Inagaki et al., 2005)

PP2B

(Morrison et al., 2000)

PpD27

canA-14F

(Sullivan and Rubin, 2002)

Name Synonyms

Calcineurin

(Dijkers and O'Farrell, 2007, Xu et al., 1998)

Calcineurin A at 14F

(Tomita et al., 2017, Sullivan and Rubin, 2002)

Protein phosphatase D27

calcineurin

(Dijkers and O'Farrell, 2007)

calcineurin A at 14F

(Li and Dijkers, 2015)

mRNA-like ncRNA in embryogenesis 12

protein phosphatase from PCR fragment D27

(Chen, 1993.1.7)

Secondary FlyBase IDs

FBgn0030758
FBgn0005782
FBgn0086544

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

References (71)

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