FlyBase Gene Report: Dmel\ltl

General Information

Symbol

Dmel\ltl

Species

D. melanogaster

Name

larval translucida

Annotation Symbol

CG32372

Feature Type

protein_coding_gene

FlyBase ID

FBgn0268063

Gene Model Status

Current

Stock Availability

14 publicly available

Gene Summary

larval translucida (ltl) encodes a leucine-rich repeat protein involved in wing vein specification. [Date last reviewed: 2019-09-19] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Pathway
Red Book
Interactive Fly

Also Known As

l(3)tr, lethal translucida, lincRNA.S4366

Key Links

Genomic Location

Cytogenetic map

66A3-66A4

Sequence location

3L:7,518,997..7,528,013 [+]

Recombination map

3-21

RefSeq locus

NT_037436 REGION:7518997..7528013

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (5 terms)

Molecular Function (0 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (0 terms)

Biological Process (3 terms)

Terms Based on Experimental Evidence (3 terms)

CV Term

Evidence

References

involved_in imaginal disc-derived wing morphogenesis

inferred from mutant phenotype

(Szuperák et al., 2011)

involved_in imaginal disc-derived wing vein specification

inferred from mutant phenotype

(Szuperák et al., 2011)

involved_in negative regulation of BMP signaling pathway

inferred from mutant phenotype

(Szuperák et al., 2011)

Terms Based on Predictions or Assertions (0 terms)

Cellular Component (2 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

located_in extracellular space

inferred from direct assay

(Szuperák et al., 2011)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

is_active_in extracellular matrix

inferred from biological aspect of ancestor with PANTHER:PTN001224703

(GO Reference Genome Project, 2011-)

is_active_in extracellular space

inferred from biological aspect of ancestor with PANTHER:PTN001224703

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

Pathway (FlyBase)

Negative Regulators of BMP Signaling Pathway

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Snapshot

larval translucida (ltl) encodes a leucine-rich repeat protein involved in wing vein specification. [Date last reviewed: 2019-09-19]

Pathway (FlyBase)

Negative Regulators of BMP Signaling Pathway -: Negative regulators of Bone Morphogenetic Protein (BMP) signaling down-regulate the pathway, ultimately resulting in the decreased nuclear activity of the Mad/Med transcription factor complex.

Phenotypic Description (Red Book; Lindsley and Zimm 1992)

l(3)tr: lethal (3) translucida

Larvae become bloated and transparent from accumulation of abnormal amount of hemolymph. Concentration of amino acids in hemolymph higher than normal; concentration of proteins reduced. Pupation delayed one day (25); dwarfed pupae formed in inflated puparia; death follows pupation or completion of imaginal differentiation of head and thorax; abdomen never metamorphoses. After transplantation into normal hosts, imaginal disks develop normally; ovaries also develop normally and are fully capable of producing viable eggs [Sobels, 1950, Experientia 6: 139-40 (fig.)]. In pure oxygen, frequency and extent of imaginal differentiation strongly increased [Sobels and Nijenhuis, 1953, Z. Indukt. Abstamm. Vererbungsl. 85: 579-92 (fig.)]. RK3.

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\ltl for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9VS84)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.45

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

ltl-RA

FBtr0076793

NM_168218

3622

817

ltl-RB

FBtr0332144

NM_001274595

4108

817

Additional Transcript Data and Comments

Reported size (kB)

4.7, 4.4 (northern blot)

(Casal and Leptin, 1996)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

ltl-PA

FBpp0076507

90.8

817

4.70

FBpp0304454

90.8

817

4.70

Q9VS84

NP_001261524

AGB94219

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

817 aa isoforms: ltl-PA, ltl-PB

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\ltl using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

ltl_1
ltl_2

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-1.02

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 4 -- 6

anterior endoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)

mesoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)

trunk mesoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)

embryonic stage 5

mesoderm anlage

(Casal and Leptin, 1996)

embryonic stage 6 -- 17

mesoderm

(Casal and Leptin, 1996)

embryonic stage 7 -- 8

anterior endoderm anlage

(Fisher et al., 2012)

head mesoderm

(Fisher et al., 2012)

posterior endoderm

(Fisher et al., 2012)

trunk mesoderm

(Fisher et al., 2012)

embryonic stage 8

head

(Casal and Leptin, 1996)

embryonic stage 9 -- 10

head mesoderm

(Fisher et al., 2012)

trunk mesoderm

(Fisher et al., 2012)

embryonic stage 11

mesoderm | segmentally repeated

(Casal and Leptin, 1996)

embryonic stage 11 -- 12

dorsal pharyngeal muscle primordium

(Fisher et al., 2012)

head mesoderm

(Fisher et al., 2012)

somatic muscle primordium

(Fisher et al., 2012)

trunk mesoderm

(Fisher et al., 2012)

embryonic stage 13 -- 16

dorsal pharyngeal muscle cell

(Fisher et al., 2012)

embryonic brain

(Fisher et al., 2012)

embryonic/larval fat body

(Fisher et al., 2012)

larval ventral nerve cord

(Fisher et al., 2012)

embryonic stage 17

embryonic/larval fat body

(Casal and Leptin, 1996)

third instar larval stage

wing disc | restricted

(Szuperák et al., 2011)

anterior-posterior compartment boundary of the wing blade

(Szuperák et al., 2011)

wing blade | gradient

(Szuperák et al., 2011)

Additional Descriptive Data

ltl transcripts are expressed in the wing disc in an asymmetric gradient domain, centered on the row of DPP-secreting cells along the AP compartment boundary of the blade primordium.

(Szuperák et al., 2011)

Transcripts are expressed in ventral cells of the blastoderm embryo. The posterior border coincides with the posterior limit of the ventral furrow. Anteriorly, expression extends up to the anterior pole. The expression is graded with the peak at the anterior end of the embryo. During germ band extension, expression is strong in the head and much weaker in the invaginated mesoderm. In late stages of germ band extension, new expression occurs in the mesoderm in a segmentally repeated pattern. In late embryos, expression is observed in the fat body.

(Casal and Leptin, 1996)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

third instar larval stage

wing disc | restricted

(Szuperák et al., 2011)

anterior-posterior compartment boundary of the wing blade

(Szuperák et al., 2011)

wing blade | gradient

(Szuperák et al., 2011)

Additional Descriptive Data

ltl protein is observed in the wing disc in an asymmetric gradient domain, centered on the row of DPP-secreting cells along the AP compartment boundary of the blade primordium.

(Szuperák et al., 2011)

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in extracellular space

inferred from direct assay

(Szuperák et al., 2011)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\ltl in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\ltl

View exonic expression by tissue for Dmel\ltl

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0268063

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

38845/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0268063

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0052372

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0268063

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG32372

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 12 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 9 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of ltl

Transgenic constructs containing regulatory region of ltl

Aberrations (Deficiencies and Duplications) ( 6 )

Inferred from experimentation ( 6 )

Gene disrupted in

(Cook, 2014.12.4)

(Cook, 2014.12.4)

(Cook, 2014.12.4)

(Szuperák et al., 2011)

Df(3L)Exel8104

(Cook, 2014.12.4, Ryder, 2004.4.26)

Df(3L)pbl-X1

(Cook, 2014.12.4)

Inferred from location ( 6 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal

ltl^l(3)tr-1

lethal (with Df(3L)BSC375)

ltl^l(3)tr-1

lethal (with Df(3L)BSC459)

ltl^l(3)tr-1

lethal (with Df(3L)BSC875)

ltl^l(3)tr-1

lethal (with Df(3L)Exel8104)

ltl^l(3)tr-1

lethal (with Df(3L)pbl-X1)

lethal - all die before end of larval stage

lethal - all die before end of pupal stage (with ltl²)

ltl³

lethal - all die before end of pupal stage (with ltl³)

ltl²

viable

ltl^c06895

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

ltl^GD5859

viable, with Scer\GAL4^Mef2.PR

ltl^GD5859

viable, with Scer\GAL4^pnr-MD237

ltl^GD5859

viable (with ltl²)

ltl⁴

viable (with ltl⁴)

ltl²

Sterility

Allele

fertile

ltl^c06895

Other Phenotypes

Allele

some die during larval stage

some die during pupal stage (with ltl²)

ltl³

some die during pupal stage (with ltl³)

ltl²

visible, with Scer\GAL4^A9

visible, with Scer\GAL4^en-e16E

ltl^UAS.cSa

visible, with Scer\GAL4^hh-Gal4

ltl^C.UAS.GFP

visible (with ltl¹)

ltl⁴

visible (with ltl²)

ltl⁴

visible (with ltl⁴)

visible | somatic clone

ltl²

Phenotype manifest in

Allele

abdomen

ltl^l(3)tr-1

anterior crossvein, with Scer\GAL4^A9

ltl^UAS.cSa

embryonic/larval hemolymph

ltl^l(3)tr-1

larva

ltl^l(3)tr-1

larva (with ltl²)

ltl³

larva (with ltl³)

ltl²

posterior crossvein, with Scer\GAL4^A9

ltl^UAS.cSa

posterior crossvein, with Scer\GAL4^en-e16E

ltl^UAS.cSa

posterior crossvein, with Scer\GAL4^hh-Gal4

ltl^C.UAS.GFP

posterior crossvein | somatic clone

ltl²

pupa

ltl^l(3)tr-1

wing, with Scer\GAL4^A9

wing, with Scer\GAL4^en-e16E

ltl^UAS.cSa

wing, with Scer\GAL4^hh-Gal4

ltl^C.UAS.GFP

wing (with ltl¹)

ltl⁴

wing (with ltl²)

ltl⁴

wing (with ltl⁴)

wing | somatic clone

ltl²

wing vein | ectopic (with ltl¹)

ltl⁴

wing vein | ectopic (with ltl²)

ltl⁴

wing vein | ectopic (with ltl⁴)

wing vein L2 | somatic clone

ltl²

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (52)

Hsap\GP1BA

2 of 14

Yes

Hsap\IGFALS

2 of 14

Yes

Hsap\TRIL

2 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\LRRC39

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (38)

Rnor\Gp1ba

2 of 14

Yes

Rnor\Igfals

2 of 14

Yes

Rnor\Tril

2 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Rnor\Elfn1

1 of 14

Rnor\Elfn2

1 of 14

Rnor\Flrt1

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Mus musculus (laboratory mouse) (41)

Mmus\Gp1ba

2 of 14

Yes

Mmus\Lgr6

2 of 14

Yes

Mmus\Lrrc15

2 of 14

Yes

Mmus\Tril

2 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Xenopus tropicalis (Western clawed frog) (38)

Xtro\igfals

2 of 13

Yes

Xtro\nyx

2 of 13

Yes

Xtro\tril

2 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\phlpp1

1 of 13

Xtro\phlpp2

1 of 13

Xtro\podn

1 of 13

Yes

Xtro\rad50

1 of 13

Xtro\rmi1

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Danio rerio (Zebrafish) (40)

Drer\lrrtm1

2 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Drer\lrrn1

1 of 14

Drer\lrrtm4l1

1 of 14

Drer\lrrtm4l2

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Drer\si:ch211-170a17.1

1 of 14

Drer\si:ch211-180f4.1

1 of 14

Drer\si:dkey-1j5.4

1 of 14

Drer\si:dkey-90m5.4

1 of 14

Drer\si:dkey-182i3.11

1 of 14

Drer\tlr8b

1 of 14

Drer\tsku

1 of 14

Drer\vasnb

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (15)

Cele\tol-1

2 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Anopheles gambiae (African malaria mosquito) (73)

Agam\AgaP_AGAP005962

10 of 12

Yes

Agam\AgaP_AGAP000019

2 of 12

Agam\AgaP_AGAP007454

2 of 12

Yes

Agam\AgaP_AGAP007456

2 of 12

Yes

Agam\AgaP_AGAP007463

2 of 12

Yes

Agam\AgaP_AGAP007465

2 of 12

Yes

Agam\AgaP_AGAP007469

2 of 12

Yes

Agam\AgaP_AGAP007471

2 of 12

Yes

Agam\AgaP_AGAP011649

2 of 12

Yes

2 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Yes

Agam\AgaP_AGAP004485

1 of 12

Agam\AgaP_AGAP004832

1 of 12

Agam\AgaP_AGAP004913

1 of 12

Yes

Agam\AgaP_AGAP004941

1 of 12

Agam\AgaP_AGAP005273

1 of 12

Agam\AgaP_AGAP005666

1 of 12

Yes

Agam\AgaP_AGAP005667

1 of 12

Yes

Agam\AgaP_AGAP005668

1 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Yes

Agam\AgaP_AGAP007443

1 of 12

Yes

Agam\AgaP_AGAP007445

1 of 12

Agam\AgaP_AGAP007446

1 of 12

Yes

Agam\AgaP_AGAP007451

1 of 12

Agam\AgaP_AGAP007461

1 of 12

Agam\AgaP_AGAP007462

1 of 12

Yes

Agam\AgaP_AGAP007464

1 of 12

Yes

Agam\AgaP_AGAP007466

1 of 12

Agam\AgaP_AGAP007467

1 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Yes

Agam\AgaP_AGAP008172

1 of 12

Yes

Agam\AgaP_AGAP008173

1 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

Yes

Agam\AgaP_AGAP009775

1 of 12

Agam\AgaP_AGAP010804

1 of 12

Agam\AgaP_AGAP010809

1 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Yes

Agam\AgaP_AGAP011947

1 of 12

Agam\AgaP_AGAP012317

1 of 12

Agam\AgaP_AGAP012384

1 of 12

Yes

Agam\AgaP_AGAP012442

1 of 12

Agam\AgaP_AGAP012584

1 of 12

Yes

Agam\AgaP_AGAP013278

1 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (18)

Atha\AT3G15410

1 of 13

Yes

Atha\AT5G10020

1 of 13

Yes

Atha\AT5G58150

1 of 13

Yes

Atha\BAM3

1 of 13

Yes

Atha\BRI1

1 of 13

Yes

Atha\BRL3

1 of 13

Yes

Atha\ERL1

1 of 13

Yes

Atha\FLS2

1 of 13

Yes

Atha\GSO1

1 of 13

Yes

Atha\GSO2

1 of 13

Yes

Atha\PEPR1

1 of 13

Yes

Atha\PEPR2

1 of 13

Yes

Atha\PIRL4

1 of 13

Yes

Atha\PSKR2

1 of 13

Yes

Atha\RLP19

1 of 13

Yes

Atha\RLP22

1 of 13

Yes

Atha\RLP49

1 of 13

Yes

Atha\SNC1

1 of 13

Yes

Saccharomyces cerevisiae (Brewer's yeast) (1)

Scer\CYR1

1 of 13

Yes

Schizosaccharomyces pombe (Fission yeast) (0)

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:ltl. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (39)

CG32055

3 of 13

Toll-7

3 of 13

2mit

2 of 13

18w

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

chp

2 of 13

lbk

2 of 13

Toll-6

2 of 13

Tollo

2 of 13

trn

2 of 13

atk

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

rdo

1 of 13

scrib

1 of 13

sli

1 of 13

Sur-8

1 of 13

Toll-4

1 of 13

Toll-9

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 3 )

Human Ortholog

Disease

Evidence

References

GP1BA; glycoprotein Ib platelet subunit alpha

model of platelet-type bleeding disorder 3

IEA

(FlyBase, 2019-)

model of Bernard-Soulier syndrome

IEA

(FlyBase, 2019-)

model of Bernard-Soulier syndrome type A2

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Show neighbor-neighbor interactions:

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Show/hide secondary interactors
(data from AllianceMine provided by esyN)

Select Layout:

Force Directed

Circle

Concentric

Legend:

Protein

RNA

Selected Interactor(s)

Other Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

ltl - dlp

anti bait coimmunoprecipitation, western blot

(Szuperák et al., 2011)

Summary of Genetic Interactions

esyN Network Diagram

Show/hide secondary interactors
(data from AllianceMine provided by esyN)

esyN Network Key:

Suppression

Enhancement

Other Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

cv-2

suppressible

ltl

(Szuperák et al., 2011)

External Data

Linkouts

MIST (protein-protein) - An integrated Molecular Interaction Database

38845

Pathways

Signaling Pathways (FlyBase)

Negative Regulators of BMP Signaling Pathway

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Neurexins and neuroligins

Class of Gene

gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-21

Cytogenetic map

66A3-66A4

Sequence location

3L:7,518,997..7,528,013 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

66A3-66A4

Limits computationally determined from genome sequence between P{PZ}l(3)07217⁰⁸²²³&P{EP}Rac2^EP3118 and P{lacW}Nmt^j1C7

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

3-21

(FlyBase, 2016)

3-17.6

(Comeron et al., 2012)

3-18.1-22.0

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (14)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

529

ltl^l(3)tr-1 Ubx¹/TM1

17786

w¹¹¹⁸; PBac{PB}ltl^c06895

23342

y¹ w^67c23; Mi{ET1}ltl^MB01691

29527

y¹ v¹; P{TRiP.HM05205}attP2/TM3, Sb¹

44577

y¹ sc^* v¹ sev²¹; P{TRiP.HMS02873}attP2

34289

y¹ w^*; Mi{MIC}ltl^MI02191/TM3, Sb¹ Ser¹

44908

y¹ w^*; Mi{MIC}ltl^MI07981/TM3, Sb¹ Ser¹

76144

y¹ w^*; Mi{Trojan-GAL4.2}ltl^{MI02191-TG4.2}/TM3, Sb¹ Ser¹

528

ltl^l(3)tr-1 Sb¹/In(3L)P, In(3R)Ubx^P18, Me¹ Ubx¹ Ubx^P18 e⁴

Kyoto

101620

Df(3R)red-P93, ltl^l(3)tr-1 Sb¹ / In(3R)Ubx^P18, Me¹ Ubx¹ e⁴

NIG-Fly

32372R-2

P{NIG.32372R}2

VDRC

v18977

w¹¹¹⁸; P{GD5859}v18977

More stocks available...

Genomic Clones (16)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (36)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

RE09158

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0268063

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Szuperák et al., 2011)

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

ChEST reveals this is a target of Mef2.

(Junion et al., 2005)

Identification: isolated from a subtractive cDNA library enriched in sequences expressed in the mesoderm.

(Casal and Leptin, 1996)

Relationship to Other Genes

Source for database merge of

Source for merge of: CG32372 anon- EST:CL1a11

(FlyBase, 1996-)

Source for merge of: CG14836 CG7545

(FlyBase Genome Annotators, 2002-2003)

Source for merge of: ltl l(3)tr

(Cook, 2014.12.4)

Additional comments

Annotations CG14836 and CG7545 merged as CG32372 in release 3 of the genome annotation.

(FlyBase Genome Annotators, 2002-2003)

Source for merge of CG32372 anon- EST:CL1a11 was sequence comparison ( date:030620 ).

(FlyBase, 1996-)

Nomenclature History

Source for database identify of

Source for identity of: ltl CG32372

(Szuperák et al., 2011)

Nomenclature comments

Etymology

The gene is named "larval translucida" based on the translucent, edemic appearance of mutant larvae.

(Szuperák et al., 2011)

Synonyms and Secondary IDs (13)

Reported As

Symbol Synonym

CG14836

CG32372

(Hazelett et al., 2012, Japanese National Institute of Genetics, 2012.5.21, Szuperák et al., 2011, Ni et al., 2010.12.1, Perkins et al., 2009, Hueber et al., 2007, Junion et al., 2007, Sandmann et al., 2007, Tomancak et al., 2007, Biemar et al., 2006, Han et al., 2006)

CG7545

(Junion et al., 2005)

CT15760

(Hynes and Zhao, 2000)

(Casal and Leptin, 1996)

Ltl

(Umulis and Othmer, 2013, Raftery and Umulis, 2012)

anon-EST:CL1a11

l(3)tr

(Cook, 2014.12.4, Wright, 1987)

lincRNA.S4366

(FlyBase Genome Annotators, 2014, Young et al., 2012)

ltl

(Akiyama et al., 2022, Hodgson et al., 2021, Lee et al., 2018, Gene Disruption Project members, 2016-, Cook, 2014.12.4, Ozkan et al., 2013, Szuperák et al., 2011)

Name Synonyms

larval translucida

(Arefin et al., 2014, Cook, 2014.12.4, Szuperák et al., 2011)

lethal (3) translucida

lethal translucida

(Cook, 2014.12.4, Wright, 1987)

Secondary FlyBase IDs

FBgn0052372
FBgn0019866
FBgn0035794
FBgn0040836
FBgn0002519

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 35 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

38845

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9VS84

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9VS84

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0268063

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

38845/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0268063

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0268063

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG32372

MARRVEL_MODEL - MARRVEL (model organism gene)

38845

Linkouts

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0268063

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

ltl_1
ltl_2

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0052372

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0268063

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG32372

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC032683

MIST (protein-protein) - An integrated Molecular Interaction Database

38845

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Neurexins and neuroligins

References (61)

The following external sites may use different assemblies or annotations than FlyBase.

-1.02

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