FAS, fatty acid synthase, dFAS, FASN, BcDNA:GH07626
Please see the JBrowse view of Dmel\FASN1 for information on other features
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AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.47
Low-frequency RNA-Seq exon junction(s) not annotated.
None of the polypeptides share 100% sequence identity.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\FASN1 using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
FASN1 expression is detected in both internal organs and leftover carcass by RT-qPCR.
JBrowse - Visual display of RNA-Seq signals
View Dmel\FASN1 in JBrowse2-8
2-6.7
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Fatty acid synthase (FASN) is encoded by three distinct genes: CG3523, CG3524 and CG17374. Of these, CG3523 is the only FASN gene that is expressed in internal organs, has an essential function (outside of oenocytes), and whose expression affects total triacylglycerol levels in vivo.
The gene referred to as "CG3525" in Table 2 of FBrf0201413 should have been referred to as "CG3523".
Identified in an RNAi screen for host factors that alter infection of SL2 cells by M.fortuitum.
Source for merge of: BcDNA:GH07626 anon- EST:Posey235 anon- EST:Posey43
Source for merge of: CG3523 anon-WO0138581.1
Source for merge of: CG3523 Fas
Source for merge of CG3523 anon-WO0138581.1 was sequence comparison ( date:051113 ).
There are 3 Fatty acid synthase genes in the Dmel genome (FBrf0219401, FBrf0224329): CG3523, CG3524 and CG17374. Through to the FB2015_01 release, there was also an unannotated gene called 'Fas' ('Fatty acid synthase', FBgn0022805), which had no biological data attached but did have 23 associated publications (published between 1990-2015). Of these 23 publications, 15 are actually specifically referring to the CG3523 gene; 2 do not specify which 'Fatty acid synthase' gene they are referring to; and 6 early papers (published 1990-1999) refer to a fatty acid synthase 'activity'. These latter 8 papers are likely assaying the CG3523 gene product as this is the major, ubiquitously expressed Fatty acid synthase of the three (see FBrf0219401, FBrf0224329, modENCODE RNA-Seq). Therefore, the unannotated 'Fas' gene has been merged with 'CG3523'.
Source for identity of: FASN1 CG3523
There are 3 Fatty acid synthase genes in the Dmel genome (FBrf0219401, FBrf0224329): CG3523 (aka FAS), CG3524 (aka mFAS) and CG17374. The CG3523 gene product is the major, ubiquitously expressed Fatty acid synthase of the three (and the most studied), while CG3524 and CG17374 have lower and more restricted expression (FBrf0219401, FBrf0224329; also see modENCODE RNAseq). The following systematic and informative symbols have therefore been adopted: CG3523 = 'FASN1', CG3524 = 'FASN2' and CG17374 = 'FASN3'. ('FASN', rather than 'FAS', has been used as a shared prefix as this more clearly distinguishes these 'Fatty acid synthase' genes from the unrelated 'faint sausage' gene (symbol 'fas') and 'Fasciclin' genes (symbols 'Fas1', 'Fas2' and 'Fas3'). Furthermore 'FASN' is the HGNC symbol for the human ortholog.)
