Open Close
General Information
Symbol
Dmel\S6k
Species
D. melanogaster
Name
Ribosomal protein S6 kinase
Annotation Symbol
CG10539
Feature Type
FlyBase ID
FBgn0283472
Gene Model Status
Stock Availability
Gene Snapshot
Ribosomal protein S6 kinase (S6k) encodes an important component of the target of rapamycin pathway. It is involved in the control of synapse development, autophagy and cell size. [Date last reviewed: 2019-09-12]
Also Known As
dS6K, S6 kinase, p70S6K, fs(3)07084, RPS6-p70-protein kinase
Key Links
Genomic Location
Cytogenetic map
Sequence location
3L:5,797,549..5,810,931 [-]
Recombination map
3-15
Sequence
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
Function
GO Summary Ribbons
Gene Group (FlyBase)
Protein Family (UniProt)
-
Summaries
Gene Group (FlyBase)
AGC KINASES (UNCLASSIFIED) -
The AGC kinase subfamily are serine/threonine kinases that were originally defined based on the sequence similarity of the catalytic domain. The AGC KINASE (UNCLASSIFIED) gene group represents AGC kinases that do not fall into the PKA, PKC or PKG families. (Adapted from FBrf0132098 and PMID:20027184).
Pathway (FlyBase)
Insulin-like Receptor Signaling Pathway Core Components -
The Insulin-like Receptor (IR) signaling pathway in Drosophila is initiated by the binding of an insulin-like peptides to the Insulin-like receptor (InR). (Adapted from FBrf0232297, FBrf0230017 and FBrf0229989.)
Platelet-Derived Growth Factor-Vascular Endothelial Growth Factor Receptor-Related Signaling Pathway Core Components -
PDGF/VEGF-receptor related (Pvr) encodes a receptor tyrosine kinase activated by the binding of PDGF- and VEGF-related factors (Pvf1,Pvf2 or Pvf3). Pvr has been shown to activate the canonical Ras/Raf/MAP kinase (ERK) cascade, the PI3K kinase pathway, TORC1 (FBrf0222697), Rho family small GTPases (FBrf0221764, FBrf0180198) and the JNK cascade (FBrf0180198), in a context-dependent manner. (Adapted from FBrf0222697 and FBrf0221727).
Summary (Interactive Fly)
signaling - regulates growth response - targets ribosomal protein S6 - a target of the TOR pathway - essential for Myc-dependent rDNA transcription
Gene Model and Products
Number of Transcripts
2
Number of Unique Polypeptides
1

Please see the GBrowse view of Dmel\S6k or the JBrowse view of Dmel\S6k for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model
Gene model reviewed during 5.45
Gene model reviewed during 5.43
Gene model reviewed during 5.46
Low-frequency RNA-Seq exon junction(s) not annotated.
Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated
Sequence Ontology: Class of Gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
FBtr0077114
3486
490
FBtr0333264
4885
490
Additional Transcript Data and Comments
Reported size (kB)
5.0, 3.7, 2.8 (northern blot)
5.0, 3.7 (northern blot)
5.0, 3.0, 2.5, 2.3 (northern blot)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
FBpp0076820
55.4
490
5.93
FBpp0305462
55.4
490
5.93
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

490 aa isoforms: S6k-PA, S6k-PB
Additional Polypeptide Data and Comments
Reported size (kDa)
637 (aa); 73 (kD predicted)
637 (aa); 76 (kD predicted)
Comments
Two peaks of S6 kinase activity were observed in S2 cells, one of which is rapamycin sensitive. The cloned S6k was shown to have identity with the rapamycin sensitive form.
External Data
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\S6k using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Gene Ontology (33 terms)
Molecular Function (4 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
inferred from biological aspect of ancestor with PANTHER:PTN000682065
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN001219259
(assigned by GO_Central )
Biological Process (24 terms)
Terms Based on Experimental Evidence (18 terms)
CV Term
Evidence
References
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from direct assay
inferred from mutant phenotype
Terms Based on Predictions or Assertions (9 terms)
CV Term
Evidence
References
Cellular Component (5 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
inferred from high throughput direct assay
inferred from high throughput direct assay
inferred from direct assay
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
inferred from biological aspect of ancestor with PANTHER:PTN000682065
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN000682065
(assigned by GO_Central )
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data
S6k protein is detected in extracts of S2 cells.
Marker for
 
Subcellular Localization
CV Term
Evidence
References
inferred from high throughput direct assay
inferred from high throughput direct assay
inferred from direct assay
Expression Deduced from Reporters
Stage
Tissue/Position (including subcellular localization)
Reference
adult brain

Comment: expression throughout adult brain

High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\S6k in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Images
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 11 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 32 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of S6k
Transgenic constructs containing regulatory region of S6k
Deletions and Duplications ( 4 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
Sterility
Allele
Other Phenotypes
Allele
Phenotype manifest in
Allele
larval salivary gland & nucleus
wing & cell
wing & cell | somatic clone
Orthologs
Human Orthologs (via DIOPT v7.1)
Homo sapiens (Human) (17)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
12 of 15
Yes
Yes
 
12 of 15
Yes
Yes
4 of 15
No
No
4 of 15
No
No
4 of 15
No
No
 
4 of 15
No
Yes
3 of 15
No
No
3 of 15
No
No
3 of 15
No
No
3 of 15
No
No
3 of 15
No
No
3 of 15
No
No
3 of 15
No
No
2 of 15
No
Yes
1 of 15
No
No
 
1 of 15
No
No
1 of 15
No
No
 
Model Organism Orthologs (via DIOPT v7.1)
Mus musculus (laboratory mouse) (17)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
12 of 15
Yes
Yes
11 of 15
Yes
No
4 of 15
No
No
4 of 15
No
No
4 of 15
No
Yes
3 of 15
No
No
3 of 15
No
No
3 of 15
No
No
3 of 15
No
No
3 of 15
No
No
3 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
Rattus norvegicus (Norway rat) (17)
11 of 13
Yes
Yes
10 of 13
Yes
No
3 of 13
No
No
3 of 13
No
No
3 of 13
Yes
No
2 of 13
No
No
2 of 13
No
No
2 of 13
No
No
2 of 13
No
No
2 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
Yes
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
Xenopus tropicalis (Western clawed frog) (20)
6 of 12
Yes
Yes
3 of 12
Yes
No
3 of 12
Yes
No
2 of 12
No
No
2 of 12
No
No
2 of 12
No
No
2 of 12
No
No
2 of 12
No
No
2 of 12
No
No
1 of 12
No
No
1 of 12
No
Yes
1 of 12
No
Yes
1 of 12
No
Yes
1 of 12
No
Yes
1 of 12
No
Yes
1 of 12
No
Yes
1 of 12
No
Yes
1 of 12
No
Yes
1 of 12
No
Yes
1 of 12
No
No
Danio rerio (Zebrafish) (20)
10 of 15
Yes
Yes
8 of 15
Yes
No
4 of 15
No
No
4 of 15
No
No
4 of 15
No
Yes
3 of 15
No
No
3 of 15
No
No
3 of 15
No
No
3 of 15
No
No
3 of 15
No
No
3 of 15
No
No
3 of 15
No
No
2 of 15
No
Yes
2 of 15
Yes
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (10)
13 of 15
Yes
Yes
5 of 15
No
Yes
4 of 15
No
No
3 of 15
No
No
3 of 15
No
Yes
3 of 15
No
No
3 of 15
No
No
2 of 15
No
No
1 of 15
No
Yes
1 of 15
No
No
Arabidopsis thaliana (thale-cress) (2)
6 of 9
Yes
Yes
6 of 9
Yes
Yes
Saccharomyces cerevisiae (Brewer's yeast) (4)
5 of 15
Yes
Yes
5 of 15
Yes
Yes
3 of 15
No
Yes
3 of 15
No
Yes
Schizosaccharomyces pombe (Fission yeast) (4)
4 of 12
Yes
Yes
2 of 12
No
No
1 of 12
No
No
1 of 12
No
Yes
Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG091907US )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila melanogaster
fruit fly
Drosophila suzukii
Spotted wing Drosophila
Drosophila simulans
Drosophila sechellia
Drosophila erecta
Drosophila yakuba
Drosophila ananassae
Drosophila pseudoobscura pseudoobscura
Drosophila persimilis
Drosophila willistoni
Drosophila virilis
Drosophila mojavensis
Drosophila grimshawi
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091504D9 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mayetiola destructor
Hessian fly
Aedes aegypti
Yellow fever mosquito
Anopheles darlingi
American malaria mosquito
Anopheles gambiae
Malaria mosquito
Culex quinquefasciatus
Southern house mosquito
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W03ZY )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Danaus plexippus
Monarch butterfly
Heliconius melpomene
Postman butterfly
Apis florea
Little honeybee
Apis florea
Little honeybee
Apis mellifera
Western honey bee
Apis mellifera
Western honey bee
Bombus impatiens
Common eastern bumble bee
Bombus impatiens
Common eastern bumble bee
Bombus terrestris
Buff-tailed bumblebee
Bombus terrestris
Buff-tailed bumblebee
Linepithema humile
Argentine ant
Megachile rotundata
Alfalfa leafcutting bee
Megachile rotundata
Alfalfa leafcutting bee
Nasonia vitripennis
Parasitic wasp
Nasonia vitripennis
Parasitic wasp
Dendroctonus ponderosae
Mountain pine beetle
Tribolium castaneum
Red flour beetle
Pediculus humanus
Human body louse
Rhodnius prolixus
Kissing bug
Acyrthosiphon pisum
Pea aphid
Zootermopsis nevadensis
Nevada dampwood termite
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X03WL )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Strigamia maritima
European centipede
Strigamia maritima
European centipede
Strigamia maritima
European centipede
Ixodes scapularis
Black-legged tick
Ixodes scapularis
Black-legged tick
Stegodyphus mimosarum
African social velvet spider
Stegodyphus mimosarum
African social velvet spider
Stegodyphus mimosarum
African social velvet spider
Stegodyphus mimosarum
African social velvet spider
Stegodyphus mimosarum
African social velvet spider
Tetranychus urticae
Two-spotted spider mite
Tetranychus urticae
Two-spotted spider mite
Tetranychus urticae
Two-spotted spider mite
Daphnia pulex
Water flea
Daphnia pulex
Water flea
Daphnia pulex
Water flea
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G05Z7 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Ciona intestinalis
Vase tunicate
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Paralogs
Paralogs (via DIOPT v7.1)
Drosophila melanogaster (Fruit fly) (5)
4 of 10
3 of 10
3 of 10
1 of 10
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
Disease Model Summary Ribbon
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 3 )
Potential Models Based on Orthology ( 0 )
Human Ortholog
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 5 )
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease Associations of Human Orthologs (via DIOPT v7.1 and OMIM)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Functional Complementation Data
Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
Interactions
Summary of Physical Interactions
esyN Network Diagram
Show neighbor-neighbor interactions:
Select Layout:
Legend:
Protein
RNA
Selected Interactor(s)
Interactions Browser

Please see the Physical Interaction reports below for full details
protein-protein
Physical Interaction
Assay
References
Summary of Genetic Interactions
esyN Network Diagram
esyN Network Key:
Suppression
Enhancement

Please look at the allele data for full details of the genetic interactions
Starting gene(s)
Interaction type
Interacting gene(s)
Reference
Starting gene(s)
Interaction type
Interacting gene(s)
Reference
External Data
Linkouts
BioGRID - A database of protein and genetic interactions.
InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
MIST (genetic) - An integrated Molecular Interaction Database
MIST (protein-protein) - An integrated Molecular Interaction Database
Pathways
Gene Group - Pathway Membership (FlyBase)
Insulin-like Receptor Signaling Pathway Core Components -
The Insulin-like Receptor (IR) signaling pathway in Drosophila is initiated by the binding of an insulin-like peptides to the Insulin-like receptor (InR). (Adapted from FBrf0232297, FBrf0230017 and FBrf0229989.)
Platelet-Derived Growth Factor-Vascular Endothelial Growth Factor Receptor-Related Signaling Pathway Core Components -
PDGF/VEGF-receptor related (Pvr) encodes a receptor tyrosine kinase activated by the binding of PDGF- and VEGF-related factors (Pvf1,Pvf2 or Pvf3). Pvr has been shown to activate the canonical Ras/Raf/MAP kinase (ERK) cascade, the PI3K kinase pathway, TORC1 (FBrf0222697), Rho family small GTPases (FBrf0221764, FBrf0180198) and the JNK cascade (FBrf0180198), in a context-dependent manner. (Adapted from FBrf0222697 and FBrf0221727).
External Data
Genomic Location and Detailed Mapping Data
Chromosome (arm)
3L
Recombination map
3-15
Cytogenetic map
Sequence location
3L:5,797,549..5,810,931 [-]
FlyBase Computed Cytological Location
Cytogenetic map
Evidence for location
64F-64E11
Left limit from in situ hybridisation (FBrf0048100) Right limit from in situ hybridisation (FBrf0048100); Limits computationally determined from genome sequence between P{PZ}Bre101640 and P{PZ}vn10567
Experimentally Determined Cytological Location
Cytogenetic map
Notes
References
64E8-64E12
(determined by in situ hybridisation)
65D-65D
(determined by in situ hybridisation)
64F-64F
(determined by in situ hybridisation)
Experimentally Determined Recombination Data
Location
3-[20]
Left of (cM)
Right of (cM)
Notes
Stocks and Reagents
Stocks (22)
Genomic Clones (30)
cDNA Clones (148)
 

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequences
BDGP DGC clones
Other clones
Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

cDNA Clones, End Sequenced (ESTs)
RNAi and Array Information
Linkouts
GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
Antibody Information
Laboratory Generated Antibodies
Commercially Available Antibodies
 
Cell Signaling Technology - Commercial vendor for primary antibodies and antibody conjugates.
Other Information
Relationship to Other Genes
Source for database identify of
Source for identity of: S6k CG10539
Source for database merge of
Source for merge of: S6k Pk64F
Additional comments
BLAST of sequence given in Fig 9 of FBrf0048100 together with cytological location indicates that 'Pk64F' from FBrf0048100 corresponds to 'S6k'.
Other Comments
S6k plays a negative role for autophagy in normal conditions. When starvation induces autophagy, S6k may act as a positive regulator of autophagy.
dsRNA made from templates generated with primers directed against this gene results in an immediate reduction in cell size. Silencing both eIF-4E and S6k together does not reduce mean cell diameter to the same extent as rapamycin treatment.
S2 cells treated with dsRNA generated against this gene show reduced phagocytosis of Candida albicans compared to untreated cells.
dsRNA made from templates generated with primers directed against this gene used to treat S2 cells.
dsRNA made from templates generated with primers directed against this gene increases Akt1 phosphorylation in S2 cells.
When dsRNA constructs are made and transiently transfected into S2 cells in RNAi experiments, an increase in the proportion of G1 phase cells is seen.
Loss of S6k causes failure to induce autophagy under fed or starvation conditions or in reponse to loss of Tor. Activation of S6k does not affect autophagy induction in wild type, but increases the level of autophagy in Tor mutants.
Promotes starvation-induced autophagy in the fat body.
dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
RNAi screen using dsRNA made from templates generated with primers directed against this gene causes a phenotype when assayed in Kc167 and S2R+ cells: increased or polarized (uneven) accumulation of F-actin.
Pk61C is an upstream effector of S6k.
Identified as a gene with significant level of mRNA cycling as assessed by expression analysis using high density oligonucleotide arrays with probe generated from adult heads harvested over six time points over the course of a day.
The S6k gene product regulates cell size in a cell-autonomous manner without impinging on cell number.
Identification: Enhancer trap expression pattern survey for loci expressed in the ring gland.
The autosomal "FLP-DFS" technique (using the P{ovoD1-18} P{FRT(whs)} P{hsFLP} chromosomes) has been used to identify the specific maternal effect phenotype for the zygotic lethal mutation. S6k is required for germ cell viability or early oogenesis.
Isolated using a rat p70s6k fragment as a probe.
S6k has been cloned and sequenced.
Isolated from a cDNA library using rat p70S6k cDNA sequences as a probe, under low stringency conditions.
Isolated from a genomic library using a Pka-C1 probe.
Pk64F may encode a protein kinase.
Gene in D.melanogaster encoding product related (by sequence comparison) to the serine-threonine protein kinases of mammals. Isolated from Drosophila clones obtained with mammalian probes.
Origin and Etymology
Discoverer
Etymology
Identification
External Crossreferences and Linkouts ( 57 )
Sequence Crossreferences
NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
Other crossreferences
Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
KEGG Genes - Molecular building blocks of life in the genomic space.
KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
Linkouts
BioGRID - A database of protein and genetic interactions.
Cell Signaling Technology
Cell Signaling Technology - Commercial vendor for primary antibodies and antibody conjugates.
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
MIST (genetic) - An integrated Molecular Interaction Database
MIST (protein-protein) - An integrated Molecular Interaction Database
Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
Synonyms and Secondary IDs (55)
Reported As
Symbol Synonym
Pk64F
Pk?6
S6K
(Jeong et al., 2019, Lee et al., 2019, Meltzer, 2019-, Meltzer et al., 2019, Schinaman et al., 2019, Şentürk et al., 2019, Ayala et al., 2018, Calap-Quintana et al., 2018, Das and Cagan, 2018, Inoue et al., 2018, Lee et al., 2018, Lee et al., 2018, Staats et al., 2018, Velentzas et al., 2018, Filer et al., 2017, Kapahi et al., 2017, Lee et al., 2017, Liu and Jin, 2017, Melani et al., 2017, Murillo-Maldonado and Riesgo-Escovar, 2017, Park et al., 2017, Romero-Pozuelo et al., 2017, Strilbytska et al., 2017, Wen et al., 2017, Wu et al., 2017, Yun et al., 2017, Alfa and Kim, 2016, Allen et al., 2016, Cai et al., 2016, Jun et al., 2016, Kakanj et al., 2016, Kwak et al., 2016, Rabinovich et al., 2016, Wei et al., 2016, Xin et al., 2016, Yaniv and Schuldiner, 2016, Zhang et al., 2016, Das and Dobens, 2015, Diop et al., 2015, Fischer et al., 2015, Gross et al., 2015, Jin et al., 2015, Kim and Lee, 2015, Lin et al., 2015, Nässel et al., 2015, Rojas-Benitez et al., 2015, Tiebe et al., 2015, Wong et al., 2015, Zhang et al., 2015, Zheng et al., 2015, Bakhoum et al., 2014, Benbahouche et al., 2014, Danielsen et al., 2014, Das et al., 2014, Deivasigamani et al., 2014, Homem et al., 2014, Lanet and Maurange, 2014, Lin et al., 2014, Liu et al., 2014, Metaxakis et al., 2014, Mulakkal et al., 2014, Sun et al., 2014, Yin et al., 2014, Andersen et al., 2013, Clark et al., 2013, Das et al., 2013, Erion and Sehgal, 2013, Fropf et al., 2013, Gupta et al., 2013, Hada et al., 2013, Hartman et al., 2013, Hur et al., 2013, Ibar et al., 2013, Itskov and Ribeiro, 2013, Koyama et al., 2013, Lin et al., 2013, Luo et al., 2013, Mukherjee and Duttaroy, 2013, Rajan and Perrimon, 2013, Tixier et al., 2013, Tixier et al., 2013, Tran et al., 2013, Wong et al., 2013, Bolukbasi et al., 2012, Dimitroff et al., 2012, Homem and Knoblich, 2012, Kapuria et al., 2012, Lv et al., 2012, Pallares-Cartes et al., 2012, Papatheodorou et al., 2012, Pircs et al., 2012, Sun et al., 2012, Taillebourg et al., 2012, van der Harst et al., 2012, Wang et al., 2012, Zitserman et al., 2012, Boyd et al., 2011, Cheng et al., 2011, Kondylis et al., 2011, Lindquist et al., 2011, Murillo-Maldonado et al., 2011, Oldham, 2011, Read, 2011, Söderberg et al., 2011, Zacharogianni et al., 2011, Zhang et al., 2011, Birse et al., 2010, Bjedov et al., 2010, Cully et al., 2010, Fernández-Ayala et al., 2010, Hahn et al., 2010, Lee et al., 2010, Li et al., 2010, Liu and Lu, 2010, Ribeiro and Dickson, 2010, Sun et al., 2010, Chittaranjan et al., 2009, Koike-Kumagai et al., 2009, Nuzhdin et al., 2009, Ravi et al., 2009, Schleich and Teleman, 2009, Shen and Ganetzky, 2009, Chen et al., 2008, Choi et al., 2008, Howlett et al., 2008, Kim et al., 2008, Teleman et al., 2008, Xu et al., 2008, Ahrens et al., 2007, Dong et al., 2007, Grewal et al., 2007, Hietakangas and Cohen, 2007, Hoshizaki and Gibbs, 2007, Jovceva et al., 2007, Lee and Chung, 2007, Lee et al., 2007, Sandmann et al., 2007, Scott et al., 2007, Edgar, 2006, Friedman and Perrimon, 2006, Goraksha and Neufeld, 2006, Guertin et al., 2006, Ruvinsky, 2006, Shiojima and Walsh, 2006, Wu and Brown, 2006, Yang et al., 2006, Corradetti et al., 2005, Cygnar et al., 2005, Findlay et al., 2005, Goberdhan et al., 2005, Mikeladze-Dvali et al., 2005, Nelson et al., 2005, Scott et al., 2005, Sustar and Schubiger, 2005, Hay and Sonenberg, 2004, Pan et al., 2004, Reiling and Hafen, 2004, Scott et al., 2004, Scott et al., 2004, Gumienny and Padgett, 2003, Hafen and Stocker, 2003, Nijhout, 2003, Stocker et al., 2003, Stocker et al., 2003, Gao et al., 2002, Kozma and Thomas, 2002, Saucedo and Edgar, 2002, Potter and Xu, 2001, Radimerski et al., 2000)
S6k
(Chandran et al., 2019, Huang et al., 2019, Huichalaf et al., 2019, Kim and Choi, 2019, Bai et al., 2018, Chiku et al., 2018, Lee et al., 2018, Nowak et al., 2018, Singh and Chowdhuri, 2018, Stobdan et al., 2017, Transgenic RNAi Project members, 2017-, Tsuyama et al., 2017, Yoon et al., 2017, Clandinin and Owens, 2016-, Gene Disruption Project members, 2016-, Kuleesha et al., 2016, Le et al., 2016, Penney et al., 2016, Vinayagam et al., 2016, Acevedo et al., 2015, Aradska et al., 2015, Calap-Quintana et al., 2015, Danilov et al., 2015, Francis and Ghabrial, 2015, Germain et al., 2015, Kim et al., 2015, Onyenwoke et al., 2015, Sopko et al., 2015, Morelli et al., 2014, Mulakkal et al., 2014, Sato-Miyata et al., 2014, Sopko et al., 2014, Villa-Cuesta et al., 2014, Kim et al., 2013, Kwon et al., 2013, Quan et al., 2013, Schertel et al., 2013, Soh et al., 2013, Sopko and Perrimon, 2013, Dar et al., 2012, Eleftherianos and Castillo, 2012, Gurudatta et al., 2012, Pritchett and McCall, 2012, Tokusumi et al., 2012, Yaniv et al., 2012, Alic et al., 2011, Friedman et al., 2011, Glatter et al., 2011, Tang et al., 2011, Willecke et al., 2011, Cho et al., 2010, Kim et al., 2010, Kockel et al., 2010, Kong et al., 2010, Lee et al., 2010, Montagne et al., 2010, Sun et al., 2010, Zheng and Sehgal, 2010, Alvarez-Ponce et al., 2009, Shen and Ganetzky, 2009, Sims et al., 2009, Wang et al., 2009, Chen et al., 2008, Hou et al., 2008, McClure and Schubiger, 2008, Buszczak et al., 2007, Knox et al., 2007, Hennig et al., 2006, Khurana et al., 2006, Patel and Tamanoi, 2006, Stroschein-Stevenson et al., 2006, Stanyon et al., 2004)
l(3)07084
p70<up>S6 kinase</up>
p70S6kinase
Secondary FlyBase IDs
  • FBgn0015806
  • FBgn0010455
  • FBgn0011551
  • FBgn0004460
Datasets (1)
Study focus (1)
Experimental Role
Project
Project Type
Title
  • bait_protein
Interaction map generated by purification of insulin pathway factors, with identification of copurifying proteins by mass spectrometry.
References (470)