FlyBase Gene Report: Dmel\S6KL

General Information

Symbol

Dmel\S6KL

Species

D. melanogaster

Name

S6 Kinase Like

Annotation Symbol

CG7001

Feature Type

protein_coding_gene

FlyBase ID

FBgn0283473

Gene Model Status

Current

Stock Availability

23 publicly available

Gene Summary

S6 Kinase Like (S6KL) encodes a serine/threonine kinase that inhibits BMP signaling through facilitating degradation of the BMP receptor encoded by tkv. It inhibits neuromuscular junction growth and promotes synaptic endocytosis at the neuromuscular junctions. [Date last reviewed: 2019-03-14] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Pathway
Gene Group
UniProtKB
Interactive Fly

Also Known As

Bin4, Pk17E, 3-10, Protein kinase-like 17E

Key Links

Genomic Location

Cytogenetic map

17D6-17E1

Sequence location

X:18,788,464..18,806,057 [+]

Recombination map

1-60

RefSeq locus

NC_004354 REGION:18788464..18806057

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (8 terms)

Molecular Function (2 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

enables protein serine/threonine kinase activity

inferred from direct assay

(Zhao et al., 2015)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

enables ATP binding

inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR045270

(InterPro Project Members, 2004-)

enables protein serine/threonine kinase activity

inferred from biological aspect of ancestor with PANTHER:PTN008614469

(GO Reference Genome Project, 2011-)

inferred from electronic annotation with InterPro:IPR045270

(InterPro Project Members, 2004-)

Biological Process (3 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

involved_in negative regulation of BMP signaling pathway

inferred from mutant phenotype

(Zhao et al., 2015)

involved_in negative regulation of neuromuscular junction development

inferred from mutant phenotype

(Zhao et al., 2015)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

involved_in TORC1 signaling

inferred from biological aspect of ancestor with PANTHER:PTN000682103

(GO Reference Genome Project, 2011-)

Cellular Component (3 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

located_in cytosol

inferred from direct assay

(Zhao et al., 2015)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

is_active_in cytoplasm

inferred from biological aspect of ancestor with PANTHER:PTN008614612

(GO Reference Genome Project, 2011-)

is_active_in nucleoplasm

inferred from biological aspect of ancestor with PANTHER:PTN000682103

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

UNCLASSIFIED AGC KINASES

Pathway (FlyBase)

Negative Regulators of BMP Signaling Pathway

Protein Family (UniProt)

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. (Q9VWQ2)

Protein Signatures (InterPro)

Summaries

Gene Snapshot

Gene Group (FlyBase)

UNCLASSIFIED AGC KINASES -: This group comprises AGC kinases that do not classify under other groups in FlyBase.

Pathway (FlyBase)

Negative Regulators of BMP Signaling Pathway -: Negative regulators of Bone Morphogenetic Protein (BMP) signaling down-regulate the pathway, ultimately resulting in the decreased nuclear activity of the Mad/Med transcription factor complex.

Protein Function (UniProtKB)

Displays kinase activity. Inhibits neuromuscular junction (NMJ) growth by interacting with and promoting the proteasome-mediated degradation of the receptor tkv which inhibits bone morphogenetic protein (BMP) signaling.

(UniProt, Q9VWQ2)

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\S6KL for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9VWQ2)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.52

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

S6KL-RA

FBtr0074634

NM_080122

2129

483

S6KL-RB

FBtr0307198

NM_001258813

1651

169

S6KL-RC

FBtr0307199

NM_001258814

2123

481

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

S6KL-PA

FBpp0074405

55.4

483

8.96

FBpp0298027

19.4

169

5.63

NP_001245742

AFH07455

S6KL-PC

FBpp0298028

55.1

481

8.96

NP_001245743

AFH07456

Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Subunit Structure (UniProtKB)

Interacts with tkv.

(UniProt, Q9VWQ2)

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Q9VWQ2

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\S6KL using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.91

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 4 -- 6

organism

(Fisher et al., 2012)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in cytosol

inferred from direct assay

(Zhao et al., 2015)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\S6KL in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\S6KL

View exonic expression by tissue for Dmel\S6KL

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0004462

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

45970/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0283473

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0004462

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0283473

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG7001

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 19 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 9 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of S6KL

Transgenic constructs containing regulatory region of S6KL

Aberrations (Deficiencies and Duplications) ( 1 )

Inferred from experimentation ( 1 )

Gene disrupted in

Df(1)Exel7464

(Ryder, 2004.4.26)

Inferred from location ( 23 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

viable

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

S6KL^GD10589

viable, with Scer\GAL4^pnr-MD237

S6KL^GD10589

viable, with Scer\GAL4^tin.CΔ4

S6KL^GD10589

Sterility

Allele

female semi-sterile, with Scer\GAL4^{VP16.nanos.UTR}, Scer\GAL4^VP16.otu, Scer\GAL4^nanos.PG

S6KL^GL00049

fertile

Other Phenotypes

Allele

abnormal neuroanatomy

S6KL¹⁴⁰

abnormal neuroanatomy, with Scer\GAL4^elav.PU

abnormal neuroanatomy | larval stage, with Scer\GAL4^elav-C155

S6KL^EP438

abnormal neurophysiology

S6KL¹⁴⁰

Phenotype manifest in

Allele

anterior fascicle & synapse, with Scer\GAL4^elav-C155

S6KL^EP438

embryonic/larval neuromuscular junction

S6KL¹⁴⁰

embryonic/larval neuromuscular junction, with Scer\GAL4^elav.PU

embryonic/larval neuromuscular junction (with Df(1)ED7413)

S6KL¹⁴⁰

NMJ bouton, with Scer\GAL4^elav.PU

NMJ bouton | increased number

S6KL¹⁴⁰

NMJ bouton | increased number (with Df(1)ED7413)

S6KL¹⁴⁰

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (33)

Hsap\RSKR

8 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (19)

Rnor\Rps6kb1

2 of 14

Yes

Rnor\Rps6kb2

2 of 14

Yes

Rnor\Sgk2

2 of 14

Yes

Rnor\Stk32a

2 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Mus musculus (laboratory mouse) (20)

Mmus\Rskr

5 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Xenopus tropicalis (Western clawed frog) (11)

Xtro\rskr

4 of 13

Yes

Xtro\bub1b

1 of 13

Xtro\bub1

1 of 13

Xtro\LOC101731784

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Danio rerio (Zebrafish) (22)

Drer\rskra

8 of 14

Yes

Drer\rskrb

8 of 14

Yes

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Drer\si:ch211-195b13.1

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (16)

Cele\F31E3.2

7 of 14

Yes

2 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Cele\rskn-1

1 of 14

Cele\rskn-2

1 of 14

Cele\sgk-1

1 of 14

Anopheles gambiae (African malaria mosquito) (11)

Agam\AgaP_AGAP000234

9 of 12

Yes

2 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (59)

Atha\PK1

2 of 13

Yes

Atha\S6K2

2 of 13

Yes

Atha\AT1G11330

1 of 13

Yes

Atha\AT1G11340

1 of 13

Yes

Atha\AT1G11410

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Atha\AT1G61460

1 of 13

Yes

Atha\AT1G61480

1 of 13

Yes

Atha\AT1G61490

1 of 13

Yes

Atha\AT1G61500

1 of 13

Yes

Atha\AT1G61550

1 of 13

Yes

Atha\AT1G61610

1 of 13

Yes

Atha\AT1G80870

1 of 13

Yes

Atha\AT2G14510

1 of 13

Atha\AT2G19230

1 of 13

Yes

Atha\AT2G20635

1 of 13

Atha\AT2G45590

1 of 13

Yes

Atha\AT3G03940

1 of 13

Atha\AT3G17850

1 of 13

Atha\AT3G59740

1 of 13

Yes

Atha\AT3G59750

1 of 13

Yes

Atha\AT4G02410

1 of 13

Atha\AT4G03230

1 of 13

Atha\AT4G11900

1 of 13

Yes

Atha\AT4G25390

1 of 13

Yes

Atha\AT4G27290

1 of 13

Yes

Atha\AT4G29050

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Atha\AT5G51770

1 of 13

Yes

Atha\AT5G56460

1 of 13

Atha\AT5G66790

1 of 13

Atha\BSK1

1 of 13

Yes

Atha\BSK8

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Atha\LECRKA4.2

1 of 13

Yes

Atha\LecRK-I.9

1 of 13

Yes

Atha\NIK1

1 of 13

Atha\RLK4

1 of 13

Yes

Atha\RLK

1 of 13

Atha\RPK1

1 of 13

Yes

Atha\WAKL4

1 of 13

Yes

Saccharomyces cerevisiae (Brewer's yeast) (11)

Scer\SCH9

2 of 13

Yes

Scer\YPK1

2 of 13

Yes

Scer\YPK2

2 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Schizosaccharomyces pombe (Fission yeast) (6)

Spom\psk1

2 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:S6KL. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (18)

S6k

2 of 13

Akt

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

for

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

RSKR; ribosomal protein S6 kinase related

8 of 14

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Show neighbor-neighbor interactions:

Off

Show/hide secondary interactors
(data from AllianceMine provided by esyN)

Select Layout:

Force Directed

Circle

Concentric

Legend:

Protein

RNA

Selected Interactor(s)

Other Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

S6KL - Ube3a

anti tag coimmunoprecipitation, anti tag western blot

(Li et al., 2016)

S6KL - tkv

anti tag coimmunoprecipitation, anti tag western blot

(Li et al., 2016, Zhao et al., 2015)

Summary of Genetic Interactions

esyN Network Diagram

Show/hide secondary interactors
(data from AllianceMine provided by esyN)

esyN Network Key:

Suppression

Enhancement

Other Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

S6KL

suppressible

Mad

(Zhao et al., 2015)

S6KL

suppressible

tkv

(Zhao et al., 2015)

S6KL

suppressible

wit

(Zhao et al., 2015)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Subunit Structure (UniProtKB)

Interacts with tkv.

(UniProt, Q9VWQ2 )

Linkouts

MIST (protein-protein) - An integrated Molecular Interaction Database

45970

Pathways

Signaling Pathways (FlyBase)

Negative Regulators of BMP Signaling Pathway

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

AKT phosphorylates targets in the nucleus

Class of Gene

gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

1-60

Cytogenetic map

17D6-17E1

Sequence location

X:18,788,464..18,806,057 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

17D6-17E1

Limits computationally determined from genome sequence between P{EP}Pk17E^EP438 and P{EP}EP1597

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

17E-17E

(determined by in situ hybridisation)

(Zhu and Hanes, 2000, Kalderon and Rubin, 1988)

17E-17E

(Zhu, 1998.10.2)

Experimentally Determined Recombination Data

Location

1-60

(FlyBase, 2016)

1-60.0

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (23)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

64244

w¹¹¹⁸; P{UAS-S6KL.K139Q}2/CyO

64241

y¹ w^67c23 S6KL¹⁴⁰

64242

y¹ w^67c23 S6KL¹⁵⁸

28757

y¹ v¹; P{TRiP.JF03185}attP2

FlyORF

F003559

M{UAS-S6KL.ORF.3xHA.GW}ZH-86Fb

10633

10761

10805

v101951

v102179

v26006

w¹¹¹⁸ P{GD10589}v26006

v47326

w¹¹¹⁸ P{GD10589}v47326

More stocks available...

Genomic Clones (19)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (97)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

LD21956

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0283473

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

RNAi and Array Information

Linkouts

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Zhao et al., 2015)

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R⁺ cell morphology.

(Kiger et al., 2003)

Identification: as a protein that interacts with the Appl cytoplasmic domain in a yeast two-hybrid assay.

(Taru et al., 2002)

Identification: Interacts with bcd protein bound to DNA in a modified yeast two-hybrid screen.

(Zhu and Hanes, 1998)

Identification: Binding partner of bcd in a modified two hybrid selection screen.

(Zhu and Hanes, 1997)

Isolated from a genomic library using a Pka-C1 probe.

(Kalderon and Rubin, 1988)

Pk17E may encode a protein kinase.

(Kalderon and Rubin, 1988)

Gene in D.melanogaster encoding product related (by sequence comparison) to the serine-threonine protein kinases of mammals. Isolated from Drosophila clones obtained with mammalian probes.

Relationship to Other Genes

Source for database merge of

Source for merge of: Pk17E Bin4

(Bayraktaroglu, 2000.11.2)

Source for merge of: S6KL BcdK

(FlyBase, 1992-)

Additional comments

'BcdK' is an unannotated gene only mentioned in FBrf0100475 (a conference abstract), but subsequent references from the same authors suggest that 'BcdK' corresponds to 'S6KL'.

(FlyBase, 1992-)

Nomenclature History

Source for database identify of

Source for identity of: S6KL Pk17E

(Zhao et al., 2015)

Source for identity of: Bin4 CG7001

(Li, 1999.11)

Nomenclature comments

Etymology

Synonyms and Secondary IDs (15)

Reported As

Symbol Synonym

3-10

(Kalderon and Rubin, 1988)

BIN4

(Bjorklund et al., 2006, Morrison et al., 2000)

BcdK

Bin4

(Taru et al., 2002, Kraut et al., 2001, Kraut et al., 2001, Zhu and Hanes, 1998, Jin et al., 1997)

CG7001

(Ni et al., 2011.7.19, Keleman et al., 2009.8.5, Perkins et al., 2009, Kraut et al., 2001, Morrison et al., 2000)

PK17E

(Hsiao et al., 2014)

Pk17E

(Khan et al., 2021, Bouleau and Tricoire, 2015, Zhao et al., 2015, Sopko et al., 2014)

Pk?4

S6KL

(Guo et al., 2019, Gene Disruption Project members, 2016-, Li et al., 2016, Zhao et al., 2015)

bin4

(Zhu and Hanes, 2000)

pk17e

(Mattila et al., 2008)

Name Synonyms

Bcd interacting protein K

(Zhu and Hanes, 1997)

Bicoid interacting protein 4

(Zhu and Hanes, 1998)

Protein kinase-like 17E

(Gonsalves et al., 2011)

S6 Kinase Like

Secondary FlyBase IDs

FBgn0004462
FBgn0024489
FBgn0024143

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 47 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

45970

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9VWQ2

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

Q9VWQ2

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9VWQ2

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0004462

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

45970/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0283473

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0283473

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG7001

MARRVEL_MODEL - MARRVEL (model organism gene)

45970

Linkouts

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0283473

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0004462

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0283473

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG7001

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC031289

MIST (protein-protein) - An integrated Molecular Interaction Database

45970

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

AKT phosphorylates targets in the nucleus

References (58)

The following external sites may use different assemblies or annotations than FlyBase.

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