FlyBase Gene Report: Dmel\nw

General Information

Symbol

Dmel\nw

Species

D. melanogaster

Name

narrow

Annotation Symbol

CG43164

Feature Type

protein_coding_gene

FlyBase ID

FBgn0283508

Gene Model Status

Current

Stock Availability

21 publicly available

Gene Summary

Contribute a Gene Snapshot for this gene.

All Summaries

Alliance
Auto summary
Gene Group
Red Book
Interactive Fly

Also Known As

anon2D7

Key Links

Genomic Location

Cytogenetic map

54B18-54C1

Sequence location

2R:17,502,354..17,508,645 [+]

Recombination map

2-82

RefSeq locus

NT_033778 REGION:17502354..17508645

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (6 terms)

Molecular Function (2 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

enables carbohydrate binding

inferred from biological aspect of ancestor with PANTHER:PTN001105053

(GO Reference Genome Project, 2011-)

enables pattern recognition receptor activity

inferred from biological aspect of ancestor with PANTHER:PTN001105054

(GO Reference Genome Project, 2011-)

Biological Process (2 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

involved_in regulation of imaginal disc-derived wing size

inferred from mutant phenotype

(Ray et al., 2015)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

involved_in immune response

inferred from biological aspect of ancestor with PANTHER:PTN001105054

(GO Reference Genome Project, 2011-)

Cellular Component (2 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

located_in extracellular space

inferred from direct assay

(Ray et al., 2015)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

is_active_in external side of plasma membrane

inferred from biological aspect of ancestor with PANTHER:PTN001105053

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

C-TYPE LECTIN-LIKE

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Group (FlyBase)

C-TYPE LECTIN-LIKE -: C-type lectins are Ca²⁺-dependent carbohydrate-binding proteins. They possess a C-type lectin fold, that is also present in proteins that do not bind carbohydrates. (Adapted from PMID:20301263.)

Phenotypic Description (Red Book; Lindsley and Zimm 1992)

*nw: narrow

Wings long, narrow, and somewhat pointed. Low viability and fertility in both sexes. At 25C, may overlap wild type; at 19, nearly all flies approach wild type but have longer wings. RK2.

nw2

nw2: narrow 2

From Payne, 1924, Genetics 9: 327-42.

Wings like nw, long, narrow, and somewhat pointed. Classification easier in females. Slight notching or tufting of marginal hairs on tip of wings. Both sexes nearly sterile. Ovaries tumorous at eclosion [King, Burnett, and Staley, 1957, Growth 21: 239-61 (fig.); King, 1964, Roy. Entomol. Soc. (London) Symp. Insect Reproduction, pp. 13-25]. Oogonia proliferate asynchronously within ovariole; follicle development inhibited [Beatty, 1949, Proc. R. Soc. Edinburgh, B 63: 249-70 (fig.)]. RK2.

nwB: narrow-Blade

Wings of nwB/+ long and narrow; variable but does not overlap wild type. Female fertility reduced. Homozygote and nwB/nw2 heterozygote lethal. RK2.

nwD: narrow-Dominant

Wings of heterozygote longer and narrower than normal. Expression variable and sometimes approaches wild type. Viability of nwD/+ low. Homozygous lethal, as is nwD/nw2. RK2.

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\nw for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry C3KGN2)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.50

Low-frequency RNA-Seq exon junction(s) not annotated.

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

nw-RA

FBtr0305701

NM_001032266

2450

194

nw-RB

FBtr0305702

NM_001202034

2447

193

nw-RC

FBtr0305703

NM_001032264

2338

491

nw-RD

FBtr0305704

NM_001259468

1962

194

nw-RE

FBtr0305705

NM_001032265

2012

490

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

nw-PA

FBpp0296981

21.7

194

5.74

FBpp0296982

21.6

193

5.74

FBpp0296983

54.2

491

4.13

FBpp0296984

21.7

194

5.74

FBpp0296985

54.2

490

4.13

A1ZAU3

NP_001027436

AAF57851

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

194 aa isoforms: nw-PA, nw-PD

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\nw using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.38

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 10 -- 11

embryonic/larval tracheal section

(Chung et al., 2011)

embryonic stage 11 -- 12

clypeo-labral primordium

(Fisher et al., 2012)

foregut primordium

(Fisher et al., 2012)

gnathal primordium

(Fisher et al., 2012)

maxillary sensory complex primordium

(Fisher et al., 2012)

tracheal primordium

(Fisher et al., 2012)

ventral epidermis primordium

(Fisher et al., 2012)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in extracellular space

inferred from direct assay

(Ray et al., 2015)

Expression Deduced from Reporters

Reporter: P{UASp-nw-GFP}

Stage

Tissue/Position (including subcellular localization)

Reference

pupal stage P6

pulvillus

(Tanaka et al., 2023)

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\nw in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\nw

View exonic expression by tissue for Dmel\nw

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0262720

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

3772015/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0283508

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0283508

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG33006

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 8 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 9 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of nw

Transgenic constructs containing regulatory region of nw

Aberrations (Deficiencies and Duplications) ( 0 )

Inferred from experimentation ( 0 )

Inferred from location ( 3 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal | recessive

nw^B

partially lethal

nw¹

partially lethal, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

nw^GD4770

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

nw^GD17618

viable, with Scer\GAL4^Mef2.PR

viable, with Scer\GAL4^pnr-MD237

nw^GD8341

viable, with Scer\GAL4^tin.CΔ4

Sterility

Allele

female semi-fertile | dominant

nw^B

female sterile

nw²

male sterile

nw²

semi-sterile

nw¹

Other Phenotypes

Allele

abnormal behavior | adult stage

nw^B

some die during pupal stage, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

nw^GD4770

visible

visible, with Scer\GAL4^nub.PU

nw^GD17618

visible | dominant

Phenotype manifest in

Allele

egg chamber

nw²

female germline stem cell

nw²

ovary

nw²

tarsus | adult stage

nw^B

tarsus | adult stage (with Df(2R)BSC406)

nw²

wing

wing, with Scer\GAL4^nub.PU

nw^GD17618

wing margin bristle

nw²

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (37)

Hsap\CLEC4M

3 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\COLEC10

1 of 14

Hsap\COLEC11

1 of 14

Hsap\LAYN

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (38)

Rnor\Cd209c

2 of 14

Yes

Rnor\Cd209f

2 of 14

Yes

Rnor\Clec4b2

2 of 14

Yes

Rnor\Clec4f

2 of 14

Yes

Rnor\Fcer2

2 of 14

Yes

Rnor\LOC100363064

2 of 14

Yes

Rnor\RGD1564571

2 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Rnor\Colec10

1 of 14

Rnor\Colec11

1 of 14

Rnor\LOC688858

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Mus musculus (laboratory mouse) (40)

Mmus\Cd209a

2 of 14

Yes

Mmus\Cd209c

2 of 14

Yes

Mmus\Cd209e

2 of 14

Yes

Mmus\Cd209g

2 of 14

Yes

Mmus\Clec4a4

2 of 14

Yes

Mmus\Clec4f

2 of 14

Yes

Mmus\Fcer2a

2 of 14

Yes

Mmus\Reg1

2 of 14

Yes

Mmus\Reg2

2 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Mmus\Layn

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Xenopus tropicalis (Western clawed frog) (20)

Xtro\reg4

2 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\layn

1 of 13

Yes

Xtro\LOC100486944

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

Danio rerio (Zebrafish) (76)

Drer\illr1

3 of 14

Yes

Drer\illr2

3 of 14

Yes

Drer\illr4

3 of 14

Yes

Drer\si:ch73-86n18.1

3 of 14

Yes

Drer\si:ch73-343l4.8

3 of 14

Yes

Drer\si:ch211-214k5.3

3 of 14

Yes

Drer\si:dkey-9i23.4

3 of 14

Yes

Drer\si:dkey-9i23.5

3 of 14

Yes

Drer\zmp:0000000937

3 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

Drer\si:ch73-122g19.1

2 of 14

Drer\si:ch211-125e6.5

2 of 14

Drer\si:ch211-125e6.11

2 of 14

Drer\si:ch211-133n4.7

2 of 14

Drer\si:ch211-160b11.4

2 of 14

Yes

Drer\si:ch211-225k7.6

2 of 14

Drer\si:ch211-232p21.6

2 of 14

Drer\si:dkey-88n24.7

2 of 14

Drer\si:dkey-187i8.2

2 of 14

Drer\si:dkeyp-75b4.10

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Drer\clec19a

1 of 14

Drer\colec11

1 of 14

Drer\layna

1 of 14

Yes

Drer\lectin

1 of 14

Drer\LOC100535655

1 of 14

Yes

Drer\LOC100537240

1 of 14

Yes

Drer\LOC101884526

1 of 14

Drer\LOC101885796

1 of 14

Yes

Drer\LOC101886459

1 of 14

Yes

Drer\LOC103911722

1 of 14

Yes

Drer\LOC108179137

1 of 14

Yes

Drer\LOC110438235

1 of 14

Yes

Drer\LOC110438236

1 of 14

Yes

Drer\LOC110438686

1 of 14

Yes

Drer\LOC110438783

1 of 14

Yes

Drer\LOC110438854

1 of 14

Yes

Drer\mrc1a

1 of 14

Drer\mrc2

1 of 14

Drer\ncanb

1 of 14

Drer\si:busm1-169i8.11

1 of 14

Drer\si:ch73-111e15.1

1 of 14

Drer\si:ch211-125e6.13

1 of 14

Drer\si:ch211-125e6.14

1 of 14

Drer\si:ch211-225k7.4

1 of 14

Drer\si:ch211-282j17.3

1 of 14

Drer\si:dkey-28d5.7

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Drer\si:dkey-88n24.10

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (70)

Cele\clec-45

2 of 14

Yes

Cele\clec-50

2 of 14

Yes

Cele\clec-86

2 of 14

Yes

Cele\clec-149

2 of 14

Yes

Cele\clec-198

2 of 14

Yes

Cele\clec-199

2 of 14

Yes

Cele\C25G4.17

1 of 14

Yes

Cele\C49C3.11

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Cele\clec-79

1 of 14

Yes

Cele\clec-83

1 of 14

Cele\clec-89

1 of 14

Cele\clec-95

1 of 14

Yes

Cele\clec-96

1 of 14

Yes

Cele\clec-99

1 of 14

Cele\clec-108

1 of 14

Yes

Cele\clec-109

1 of 14

Yes

Cele\clec-111

1 of 14

Yes

Cele\clec-113

1 of 14

Yes

Cele\clec-117

1 of 14

Yes

Cele\clec-118

1 of 14

Cele\clec-121

1 of 14

Yes

Cele\clec-123

1 of 14

Yes

Cele\clec-124

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Cele\clec-156

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Cele\clec-184

1 of 14

Yes

Cele\clec-185

1 of 14

Yes

Cele\clec-191

1 of 14

Yes

Cele\clec-195

1 of 14

Yes

Cele\clec-197

1 of 14

Yes

Cele\clec-202

1 of 14

Cele\clec-203

1 of 14

Yes

Cele\clec-204

1 of 14

Cele\clec-205

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Cele\clec-238

1 of 14

Yes

Cele\clec-242

1 of 14

Yes

Cele\clec-260

1 of 14

Yes

Cele\clec-262

1 of 14

Yes

Cele\F52E1.2

1 of 14

Cele\T07H3.10

1 of 14

Yes

Cele\tps-2

1 of 14

Cele\Y38H6C.8

1 of 14

Anopheles gambiae (African malaria mosquito) (20)

Agam\AgaP_AGAP013153

7 of 12

Yes

Agam\CTL8

7 of 12

Yes

Agam\AgaP_AGAP002911

2 of 12

Agam\AgaP_AGAP010707

2 of 12

Yes

Agam\CTL2

2 of 12

Yes

2 of 12

2 of 12

2 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (0)

Saccharomyces cerevisiae (Brewer's yeast) (0)

Schizosaccharomyces pombe (Fission yeast) (0)

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:nw. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (31)

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

tfc

3 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

CLEC4M; C-type lectin domain family 4 member M

3 of 14

605872

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Show neighbor-neighbor interactions:

Off

Show/hide secondary interactors
(data from AllianceMine provided by esyN)

Select Layout:

Force Directed

Circle

Concentric

Legend:

Protein

RNA

Selected Interactor(s)

Other Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

comigration in non denaturing gel electrophoresis, molecular weight estimation by staining, anti tag coimmunoprecipitation, anti tag western blot

(Ray et al., 2015)

Summary of Genetic Interactions

esyN Network Diagram

Show/hide secondary interactors
(data from AllianceMine provided by esyN)

esyN Network Key:

Suppression

Enhancement

Other Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

enhanceable

dpy

(Ray et al., 2015)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

MIST (genetic) - An integrated Molecular Interaction Database

3772015

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Class of Gene

gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-82

Cytogenetic map

54B18-54C1

Sequence location

2R:17,502,354..17,508,645 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

54B18-54C1

Limits computationally determined from genome sequence between P{EP}l(2)k01209^EP2177&P{lacW}k11012a and P{lacW}l(2)k07433^k07433

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

2-82

(FlyBase, 2016)

2-86.2

(Comeron et al., 2012)

2-79.3 +/- 0.2

(Doane and Clark, 1984)

2-75

(Craymer, 1980)

Left of (cM)

(Doane and Clark, 1984)

PPO1

(Craymer, 1980)

Right of (cM)

mapP

(Doane, 1987)

(Doane and Clark, 1984)

(Craymer, 1980)

Notes

Based on mapping of nw².

(Doane and Clark, 1984)

Stocks and Reagents

Stocks (21)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

240

nw^B/CyO

359

nw²/In(2L)Cy, In(2R)NS, Duox^Cy

14410

y¹ w^67c23; P{SUPor-P}nw^KG02048

Kyoto

105809

nw^B/SM5

101514

In(2L)Cy In(2R)NS, Duox^Cy / nw²

107425

Df(2R)Pu-D17, nw^D βTub60D^Pin-Yt/SM1

NIG-Fly

4844R-1

P{NIG.4844R}1

HMJ22124

y¹ v¹; P{TRiP.HMJ22124}attP40/CyO

VDRC

v102446

P{KK111678}VIE-260B

v12800

w¹¹¹⁸; P{GD4770}v12800

v49678

w¹¹¹⁸; P{GD17618}v49678

v49679

w¹¹¹⁸; P{GD17618}v49679

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Genomic Clones (14)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (294)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

LD10058

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0283508

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Genetic combinations with mutants of nub cause additive phenotypes.

(Cifuentes and Garcia-Bellido, 1997)

Quantifying rates of protein sequence divergence within and between species reveals that the Drosophila genome harbors a substantial proportion of genes with a very high divergence rate.

(Schmid and Tautz, 1997)

Mutants display germline hyperplastic phenotype.

(Mechler, 1994)

Relationship to Other Genes

Source for database merge of

Source for merge of: CG18431 CG4844

(FlyBase Genome Annotators, 2011)

Source for merge of: nw CG43164

(Ray et al., 2015)

Additional comments

Annotations CG18431 and CG4844 (which were previously annotated as two non-overlapping open reading frames of a dicistronic transcript) merged as a single annotation (CG43164) in release 5.33 of the genome annotation.

(FlyBase Genome Annotators, 2011)

Nomenclature History

Source for database identify of

Nomenclature comments

Etymology

Synonyms and Secondary IDs (14)

Reported As

Symbol Synonym

Bla

CG18431

(Chung et al., 2011, FlyBase Genome Annotators, 2005, FlyBase Genome Annotators, 2002-2003)

CG33006

(Chung et al., 2011, Hurlbut et al., 2009, Burgler and Macdonald, 2005)

CG43164

(National Institute of Genetics Fly Stocks, 2023-, National Institute of Genetics Fly Stocks, 2022-, Cho et al., 2020, Lu et al., 2020, Ray et al., 2015, FlyBase Genome Annotators, 2011)

CG4844

(Gerritsma et al., 2019, Japanese National Institute of Genetics, 2012.5.21, Chung et al., 2011, Lebo et al., 2009, Altenhein et al., 2006, FlyBase Genome Annotators, 2005, FlyBase Genome Annotators, 2002-2003)

CG4844a

CG4844b

anon-EST:fe2D7

anon2D7

(Dubnau et al., 2003, Schmid, 1997.5.30)

lance

(Tanaka et al., 2023, McLaughlin et al., 2021, Cho et al., 2020, Gene Disruption Project members, 2018-, Ray et al., 2016, Ray et al., 2015, Wang et al., 2009)

Name Synonyms

Blade

anon-fast-evolving-2D7

narrow

(Ray et al., 2016, Ray et al., 2015)

Secondary FlyBase IDs

FBgn0002974
FBgn0262720
FBgn0061355
FBgn0034227
FBgn0053006
FBtr0086930
FBpp0086086
FBtr0086931
FBpp0086087
FBtr0086932
FBpp0086088
FBgn0061354
FBgn0022342

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 54 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

3772015

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

C3KGN2

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

C3KGN2

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0262720

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

3772015/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0283508

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0283508

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG43164

MARRVEL_MODEL - MARRVEL (model organism gene)

3772015

Linkouts

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0283508

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0283508

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG33006

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC014184

MIST (genetic) - An integrated Molecular Interaction Database

3772015

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

References (74)

The following external sites may use different assemblies or annotations than FlyBase.

-0.38

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