FB2020_06, released Dec 22, 2020

Gene: Dmel\lola

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General Information
Symbol
Dmel\lola
Species
D. melanogaster
Name
longitudinals lacking
Annotation Symbol
CG12052
Feature Type
protein_coding_gene
FlyBase ID
FBgn0283521
Gene Model Status
Current
Stock Availability
72 publicly available
Gene Snapshot
longitudinals lacking (lola) encodes a protein involved in Notch signaling, cell death, regulation of retrotransposons and expression of axon and dendrite patterning genes. It contributes to oogenesis, spermatogenesis, neural wiring, eye development and a variety of behaviors. [Date last reviewed: 2019-03-21]
Other Summaries
Also Known As

eyeful, btb, BTB-IV, longitudinal lacking, misguided

Key Links
Genomic Location
Cytogenetic map
47A11-47A13
Sequence location
2R:10,481,894..10,543,291 [-]
Recombination map

2-62

RefSeq locus
NT_033778 REGION:10481894..10543291
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (23 terms)
Molecular Function (3 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
enables DNA binding
inferred from direct assay
(Dinges et al., 2017)
enables protein binding
inferred from physical interaction with FLYBASE:JIL-1; FB:FBgn0020412
(Zhang et al., 2003)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
enables DNA-binding transcription factor activity
inferred from sequence or structural similarity with FLYBASE:ttk; FB:FBgn0003870
(Giniger et al., 1994)
Biological Process (17 terms)
Terms Based on Experimental Evidence (15 terms)
CV Term
Evidence
References
involved_in axon guidance
inferred from mutant phenotype
(Crowner et al., 2002, Giniger et al., 1994)
inferred from genetic interaction with FLYBASE:SoxN; FB:FBgn0029123
(Girard et al., 2006)
involved_in axon midline choice point recognition
inferred from mutant phenotype
(Crowner et al., 2002)
inferred from genetic interaction with FLYBASE:robo1; FB:FBgn0005631
(Crowner et al., 2002)
inferred from genetic interaction with FLYBASE:sli; FB:FBgn0264089
(Crowner et al., 2002)
involved_in axonogenesis
inferred from mutant phenotype
(Giniger et al., 1994)
involved_in dendrite morphogenesis
inferred from mutant phenotype
(Iyer et al., 2013)
involved_in gonad development
inferred from mutant phenotype
(Tripathy et al., 2014, Weyers et al., 2011)
involved_in larval lymph gland hemopoiesis
inferred from mutant phenotype
(Mondal et al., 2014)
involved_in larval somatic muscle development
inferred from expression pattern
(Dobi et al., 2014)
inferred from mutant phenotype
(Dobi et al., 2014)
involved_in nurse cell apoptotic process
inferred from mutant phenotype
(Bass et al., 2007)
involved_in positive regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria
inferred from high throughput mutant phenotype
(Kleino et al., 2005)
involved_in positive regulation of peptidoglycan recognition protein signaling pathway
inferred from high throughput mutant phenotype
(Kleino et al., 2005)
involved_in R3/R4 cell fate commitment
inferred from mutant phenotype
(Zheng and Carthew, 2008)
involved_in R7 cell development
inferred from mutant phenotype
(Zheng and Carthew, 2008)
involved_in regulation of axon guidance
inferred from mutant phenotype
(Dinges et al., 2017)
involved_in regulation of gene expression
inferred from mutant phenotype
(Dinges et al., 2017)
involved_in regulation of transcription, DNA-templated
inferred from mutant phenotype
(Zheng and Carthew, 2008)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
involved_in positive regulation of transcription, DNA-templated
inferred from sequence or structural similarity with UniProtKB:Q08605
(Giniger et al., 1994)
involved_in regulation of transcription by RNA polymerase II
inferred from biological aspect of ancestor with PANTHER:PTN001135010
(assigned by GO_Central )
(Gaudet et al., 2011)
Cellular Component (3 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
located_in cytoplasm
inferred from direct assay
(Dinges et al., 2017)
located_in nucleoplasm
inferred from high throughput direct assay
(Lye et al., 2014)
located_in nucleus
inferred from direct assay
(Zhang et al., 2003, Giniger et al., 1994)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
located_in nucleus
inferred from biological aspect of ancestor with PANTHER:PTN001135010
(assigned by GO_Central )
(Gaudet et al., 2011)
Gene Group (FlyBase)
Pathway (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Group (FlyBase)
C2H2 ZINC FINGER TRANSCRIPTION FACTORS -
Zinc finger C2H2 transcription factors are sequence-specific DNA binding proteins that regulate transcription. They possess DNA-binding domains that are formed from repeated Cys2His2 zinc finger motifs. (Adapted from PMID:1835093, FBrf0220103 and FBrf0155739).
Pathway (FlyBase)
Positive Regulators of Imd Signaling Pathway -
Positive regulators of the immune deficiency (Imd) pathway result in the increased activity of the NFκB-like transcription factor Rel in the nucleus. (Adapted from FBrf0224587 and FBrf0238555.)
Protein Function (UniProtKB)
Putative transcription factor required for axon growth and guidance in the central and peripheral nervous systems. Repels CNS axons away from the midline by promoting the expression of the midline repellent sli and its receptor robo.
(UniProt, P42283P42284Q7KQZ4Q867Z4Q9V5M3Q9V5M6)
Summary (Interactive Fly)

transcription factor - zinc finger - btb domain - regulates axon guidance - promotes axon growth in part by suppressing expression of the actin nucleation factor Spire - expressed in both glia and neurons - regulates cell fate by antagonizing Notch induction in the Drosophila eye

Gene Model and Products
Number of Transcripts
25
Number of Unique Polypeptides
20

Please see the JBrowse view of Dmel\lola for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Gene model reviewed during 5.49

Low-frequency RNA-Seq exon junction(s) not annotated.

Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.

gene_with_trans_spliced_transcript ; SO:0000459

Gene model reviewed during 5.51

Sequence Ontology: Class of Gene
gene
gene_with_edited_transcript
(Rodriguez et al., 2012)
gene_with_trans_spliced_transcript
(FlyBase Genome Annotators, 2012, Horiuchi et al., 2003)
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
lola-RA
FBtr0089344
NM_170623
2902
706
lola-RAA
FBtr0343132
NM_176128
4623
970
lola-RB
FBtr0089343
NM_170619
2974
787
lola-RC
FBtr0089345
NM_170618
3123
787
lola-RD
FBtr0089349
NM_170620
3423
748
lola-RE
FBtr0089342
NM_170621
3417
748
lola-RF
FBtr0089348
NM_170622
2627
565
lola-RG
FBtr0089347
NM_080027
4267
891
lola-RH
FBtr0089346
NM_170617
2146
518
lola-RI
FBtr0089350
NM_176133
4239
970
lola-RJ
FBtr0089360
NM_176130
3703
757
lola-RK
FBtr0089353
NM_176136
2055
546
lola-RL
FBtr0089352
NM_176138
2823
608
lola-RM
FBtr0089362
NM_176140
2150
465
lola-RO
FBtr0089361
NM_176129
3234
668
lola-RP
FBtr0089355
NM_176131
3875
963
lola-RQ
FBtr0089356
NM_176139
2327
603
lola-RR
FBtr0089357
NM_176132
4015
891
lola-RT
FBtr0089359
NM_176134
2245
575
lola-RU
FBtr0089351
NM_176135
2239
575
lola-RV
FBtr0089363
NM_206085
2438
549
lola-RW
FBtr0089364
NM_206084
3446
771
lola-RX
FBtr0089365
NM_206083
2938
602
lola-RY
FBtr0089366
NM_206082
2397
577
lola-RZ
FBtr0100286
NM_001032229
2707
665
Additional Transcript Data and Comments
Reported size (kB)

3.9 (northern blot)

(Zhang et al., 2003)

4.9, 4.7, 3.8 (northern blot)

(Giniger et al., 1994)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
lola-PA
FBpp0088378
75.8
706
5.15
NP_724953
AAF58775
lola-PAA
FBpp0309831
105.8
970
6.11
NP_788308
AAF58781
lola-PB
FBpp0088377
82.2
787
6.14
NP_724949
AAF58776
lola-PC
FBpp0088379
82.2
787
6.14
NP_724946
AAF58773
lola-PD
FBpp0088383
79.4
748
5.48
NP_724950
AAM68765
lola-PE
FBpp0088376
79.4
748
5.48
NP_724951
AAM68766
lola-PF
FBpp0088382
60.7
565
6.09
NP_724952
AAM68767
lola-PG
FBpp0088381
96.3
891
6.43
NP_524766
AAF58782
lola-PH
FBpp0088380
55.4
518
4.97
NP_724945
AAF58777
lola-PI
FBpp0088384
105.8
970
6.11
NP_788313
AAO41426
lola-PJ
FBpp0088394
78.7
757
6.63
NP_788310
AAF58779
lola-PK
FBpp0088387
58.9
546
6.27
NP_788316
AAM68764
lola-PL
FBpp0088386
65.4
608
6.61
NP_788318
AAO41430
lola-PM
FBpp0088396
49.3
465
4.80
NP_788320
AAO41431
lola-PO
FBpp0088395
71.8
668
4.64
NP_788309
AAO41424
lola-PP
FBpp0088389
102.7
963
5.14
NP_788311
AAF58778
lola-PQ
FBpp0088390
64.7
603
8.12
NP_788319
AAM68768
lola-PR
FBpp0088391
96.3
891
6.43
NP_788312
AAO41425
lola-PT
FBpp0088393
61.9
575
6.21
NP_788314
AAO41427
lola-PU
FBpp0088385
61.9
575
6.21
NP_788315
AAO41428
lola-PV
FBpp0088949
59.3
549
5.20
NP_995807
AAS64877
lola-PW
FBpp0088950
83.5
771
5.66
NP_995806
AAS64876
lola-PX
FBpp0088951
64.4
602
5.84
NP_995805
AAS64874
lola-PY
FBpp0088948
62.7
577
5.19
NP_995804
AAS64875
lola-PZ
FBpp0099680
70.9
665
6.60
NP_001027400
AAZ52818
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

970 aa isoforms: lola-PAA, lola-PI
891 aa isoforms: lola-PG, lola-PR
575 aa isoforms: lola-PT, lola-PU
748 aa isoforms: lola-PD, lola-PE
787 aa isoforms: lola-PB, lola-PC
Additional Polypeptide Data and Comments
Reported size (kDa)

748 (aa); 105 (kD)

(Zhang et al., 2003)

894, 467 (aa); 97, 50 (kD predicted)

(Giniger et al., 1994)
Comments

Although the calculated mass of the zf5 lola isoform is79.4 kD, it migrates at 105 kD perhaps because of its low pI.

(Zhang et al., 2003)
External Data
Subunit Structure (UniProtKB)

Isoform D interacts with JIL-1.

(UniProt, Q7KQZ4)
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Nucleotide / Polypeptide Records
 
UniProt
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\lola using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
No Assay Recorded
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 13 -- 17
histoblast
(Giniger et al., 1994)
embryonic stage 12 -- 17
central nervous system
(Giniger et al., 1994)
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 10 -- 11
mesectoderm
(Giniger et al., 1994)
embryonic stage 10 -- 17
mesoderm
(Giniger et al., 1994)
embryonic stage 12 -- 14
presumptive embryonic/larval peripheral nervous system
(Giniger et al., 1994)
embryonic stage 16 -- 17
embryonic optic lobe primordium
(Giniger et al., 1994)
embryonic/larval central nervous system
(Scully et al., 2002)
embryonic stage 13 -- 17
embryonic imaginal tissue
(Giniger et al., 1994)
embryonic stage 11
mesoderm

Comment: lola probe L (lola-RB, lola-RC)

(Goeke et al., 2003)
amnioproctodeal invagination

Comment: lola probe L (lola-RB, lola-RC)

(Goeke et al., 2003)
cell of ectoderm

Comment: lola probe J (lola-RU)

(Goeke et al., 2003)
embryonic stage 16
embryonic somatic muscle

Comment: lola probe L (lola-RB, lola-RC)

(Goeke et al., 2003)
embryonic epidermis

Comment: lola probe K (lola-RI)

(Goeke et al., 2003)
embryonic stage 17
embryonic/larval central nervous system

Comment: lola probe K (lola-RI)

(Goeke et al., 2003)
embryonic stage 5
ventral furrow

Comment: lola probe N (lola-RP)

(Goeke et al., 2003)
embryonic stage 10
tracheal pit

Comment: lola probe J (lola-RU)

(Goeke et al., 2003)
cell | subset of ventral neurectoderm

Comment: lola probe C (lola-RL)

(Goeke et al., 2003)
embryonic stage 13
presumptive embryonic/larval central nervous system | restricted

Comment: lola probe I (lola-RF); enriched in dorsal cell layer of embryonic CNS

(Goeke et al., 2003)
embryonic stage 1 -- 3
organism

Comment: maternally deposited

(Fisher et al., 2012)
embryonic stage 4 -- 6
organism | intense | ubiquitous
(Fisher et al., 2012)
embryonic stage 7 -- 8
organism | intense | ubiquitous
(Fisher et al., 2012)
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 9 -- 10
organism | intense | ubiquitous
(Fisher et al., 2012)
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 11 -- 12
central brain primordium
(Fisher et al., 2012)
dorsal sensory complex primordium
(Fisher et al., 2012)
organism | ubiquitous
(Fisher et al., 2012)
ventral nerve cord primordium
(Fisher et al., 2012)
ventral sensory complex anlage
(Fisher et al., 2012)
embryonic stage 13 -- 16
dorsal sensory complex proper primordium

Comment: reported as dorsal/lateral sensory complexes

(Fisher et al., 2012)
embryonic brain
(Fisher et al., 2012)
embryonic head sensory system
(Fisher et al., 2012)
organism | ubiquitous
(Fisher et al., 2012)
ventral nerve cord
(Fisher et al., 2012)
ventral sensory complex primordium
(Fisher et al., 2012)
embryonic stage
ventral midline of embryo
(Wheeler et al., 2009)
spermatogenesis & adult stage | male
primary spermatocyte

Comment: probe specific to lola-RB, lola-RC, and lola-RI

(Davies et al., 2013)
adult stage | male & spermatogenesis
germinal proliferation center

Comment: probe specific to lola-RB, lola-RC, and lola-RI

(Davies et al., 2013)
northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1 -- 15
organism

Comment: 0-12 AEL

(Zhang et al., 2003)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
No Assay Recorded
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage
presumptive embryonic/larval peripheral nervous system
(Giniger et al., 1994)
tracheocyte
(Giniger et al., 1994)
embryonic/larval somatic muscle
(Giniger et al., 1994)
epithelial cell
(Giniger et al., 1994)
central nervous system
(Giniger et al., 1994)
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage
epithelial cell
(Giniger et al., 1994)
embryonic/larval somatic muscle
(Giniger et al., 1994)
central nervous system
(Giniger et al., 1994)
presumptive embryonic/larval peripheral nervous system
(Giniger et al., 1994)
tracheocyte
(Giniger et al., 1994)
embryonic stage 3 -- 4
organism
• nucleus
(Zhang et al., 2003)
larval stage -- adult stage
antennal lobe | surrounding
(Spletter et al., 2007)
neuron
(Spletter et al., 2007)
larval stage
embryonic/larval brain | ubiquitous
(Spletter et al., 2007)
adult stage
adult brain | ubiquitous
(Spletter et al., 2007)
ocellus retinula cell
(Mishra et al., 2016)
adult stage | male & spermatogenesis
male germline stem cell
(Davies et al., 2013)
cyst progenitor cell
(Davies et al., 2013)
cyst cell of testis
(Davies et al., 2013)
spermatogonium
(Davies et al., 2013)
third instar larval stage
larval dorsal multidendritic neuron ddaE
(Hattori et al., 2013)
larval dorsal multidendritic neuron ddaC
(Hattori et al., 2013)
photoreceptor cell
(Mishra et al., 2016)
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
day 5 of adulthood & male -- day 7 of adulthood & male
spermatozoon
(Dorus et al., 2006)
western blot
Stage
Tissue/Position (including subcellular localization)
Reference
third instar larval stage
(Zhang et al., 2003)
adult stage
(Zhang et al., 2003)
embryonic stage 1 -- 17
organism

Comment: 0-22 hr AEL

(Zhang et al., 2003)
organism
• nucleus

Comment: 0-22 hr AEL; different lola isoforms have different temporal distributions

(Zhang et al., 2003)
Additional Descriptive Data

lola is expressed in all neurons adjacent to the antennal lobe at all developmental stages of development from larva to adult.

(Spletter et al., 2007)

Multiple isoforms ofthe lola protein are detected throughout development. In late embryos up to 15 distinct bands can be detected on western blots using an antibody raised to the core BTB/Poz domain shared by all the predicted isoforms.

(Zhang et al., 2003)

lola protein distribution (as determined by an antibody that recognizes both protein forms) is consistent with lola transcript distribution but reveals new information. During gastrulation, the protein appears to turn over at mitosis. It is present at highest concentrations in neurons at stage 13 but is also present at substantial levels in epithelial cells and in sensory organ support cells. Unlike the RNA, lola protein is detected in mesodermal nuclei as late as stage 17. It is observed in somatic muscle and in peritracheal cells.

(Giniger et al., 1994)
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in cytoplasm
inferred from direct assay
(Dinges et al., 2017)
located_in nucleoplasm
inferred from high throughput direct assay
(Lye et al., 2014)
located_in nucleus
inferred from direct assay
(Zhang et al., 2003, Giniger et al., 1994)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\lola in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 207 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 44 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of lola
Transgenic constructs containing regulatory region of lola
Deletions and Duplications ( 15 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal
lethal, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
lethal, with Scer\GAL429BD
lethal, with Scer\GAL4btl.PS
lethal, with Scer\GAL4c355
lethal, with Scer\GAL4GH146
lethal, with Scer\GAL4how-24B
lethal, with Scer\GAL4tsh-md621
lethal (with Df(2R)12)
lethal (with Df(2R)27)
lethal (with Df(2R)BSC595)
lethal (with Df(2R)E3363)
lethal (with Df(2R)ED2076)
lethal (with Df(2R)ED2098)
lethal (with Df(2R)stan2)
lethal (with lola5D2)
lethal (with lola22.05)
lethal (with lola629)
lethal (with lola00642)
lethal (with lolaC28)
lethal (with lolac46)
lethal (with lolak09901)
lethal (with lolaORC4)
lethal (with lolaORE50)
lethal (with lolaORE120)
lethal | female limited, with Scer\GAL4Bx-MS1096
lethal | recessive
lethal - all die before end of embryonic stage | recessive
lethal - all die before end of first instar larval stage
lethal - all die during embryonic stage
lethal - all die during embryonic stage, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
lethal - all die during P-stage, with Scer\GAL4Mef2.PR
partially lethal, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
partially lethal (with lolac46)
partially lethal (with lolaORC4)
partially lethal (with lolaORE50)
partially lethal (with lolaORE119)
partially lethal (with lolaORE120)
partially lethal - majority die
partially lethal - majority die, with Scer\GAL429BD
partially lethal - majority die, with Scer\GAL4c355
partially lethal - majority die, with Scer\GAL4hs.2sev
partially lethal - majority die, with Scer\GAL4pnr-MD237
partially lethal - majority die (with lola4E4)
partially lethal - majority die (with lola629)
viable
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4pnr-MD237
viable, with Scer\GAL4tin.CΔ4
viable (with lola629)
viable (with lolac46)
viable (with lolaORC4)
viable (with lolaORE50)
viable (with lolaORE119)
viable (with lolaORE120)
Sterility
Allele
fertile
Other Phenotypes
Allele
behavior defective | recessive
body color defective, with Scer\GAL4pnr-MD237
cell migration defective | embryonic stage
cell migration defective | embryonic stage 14
cell migration defective | embryonic stage (with lola22.05)
cell migration defective | embryonic stage (with lola46.38)
courtship behavior defective | male, with Scer\GAL4fru.P1.D
decreased fecundity | female
flight defective, with Scer\GAL4Mef2.PR
hyperactive | adult stage
locomotor behavior defective, with Scer\GAL4Appl.G1a
locomotor behavior defective, with Scer\GAL4elav.PLu
locomotor behavior defective | adult stage
locomotor behavior defective | adult stage | female
melanotic mass phenotype | adult stage
melanotic mass phenotype | third instar larval stage
neuroanatomy defective
neuroanatomy defective, with Scer\GAL4221
neuroanatomy defective, with Scer\GAL4elav.PLu
neuroanatomy defective, with Scer\GAL4how-24B
neuroanatomy defective, with Scer\GAL4ppk.1.9
neuroanatomy defective, with Scer\GAL4ppk.PG
neuroanatomy defective, with Scer\GAL4twi.PG
neuroanatomy defective (with lolac46)
neuroanatomy defective (with lolae76)
neuroanatomy defective | dominant | embryonic stage
neuroanatomy defective | embryonic stage
neuroanatomy defective | embryonic stage, with Scer\GAL4elav-C155
neuroanatomy defective | larval stage
neuroanatomy defective | somatic clone
neuroanatomy defective | somatic clone, with Scer\GAL4GH146
neuroanatomy defective | somatic clone, with Scer\GAL4GH146, lola3.8.UAS
neuroanatomy defective | somatic clone, with Scer\GAL4GH146, lola4.7.UAS
neuroanatomy defective | somatic clone, with Scer\GAL4GH146, lolae76
neuroanatomy defective | somatic clone, with Scer\GAL4GH146, lolaL.UAS
neuroanatomy defective | somatic clone (with lolae76), with Scer\GAL4GH146
neuroanatomy defective | somatic clone (with lolaL.UAS), with Scer\GAL4GH146
neuroanatomy defective | somatic clone | heat sensitive, with Scer\GAL4GH146
short lived
size defective, with Scer\GAL4en-e16E
some die during embryonic stage | recessive
some die during pupal stage, with Scer\GAL4pnr-MD237
visible, with Scer\GAL4dpp.blk1
visible, with Scer\GAL4hs.2sev
visible, with Scer\GAL4pnr-MD237
visible, with Scer\GAL4sca-537.4
visible | male limited, with Scer\GAL4Bx-MS1096
wild-type, with Scer\GAL4elav.PLu
wild-type, with Scer\GAL4how-24B
wild-type, with Scer\GAL4hs.2sev
wild-type, with Scer\GAL4twi.PG
Phenotype manifest in
Allele
A1-7 ventral longitudinal muscle 1
A1-7 ventral longitudinal muscle 2
A1-7 ventral longitudinal muscle 3
A1-7 ventral longitudinal muscle 4
abdominal 1 lateral monoscolopidial chordotonal organ lch1
abdominal 1 lateral pentascolopidial chordotonal organ lch5
abdominal 2 lateral monoscolopidial chordotonal organ lch1
abdominal 2 lateral pentascolopidial chordotonal organ lch5
abdominal 3 lateral monoscolopidial chordotonal organ lch1
abdominal 3 lateral pentascolopidial chordotonal organ lch5
abdominal 4 lateral monoscolopidial chordotonal organ lch1
abdominal 4 lateral pentascolopidial chordotonal organ lch5
abdominal 5 lateral monoscolopidial chordotonal organ lch1
abdominal 5 lateral pentascolopidial chordotonal organ lch5
abdominal 6 lateral monoscolopidial chordotonal organ lch1
abdominal 6 lateral pentascolopidial chordotonal organ lch5
abdominal 7 lateral monoscolopidial chordotonal organ lch1
abdominal 7 lateral pentascolopidial chordotonal organ lch5
abdominal anterior ventral multidendritic neuron vdaa, with Scer\GAL4ppk.1.9
abdominal dorsal multidendritic neuron ddaC | somatic clone | third instar larval stage
abdominal dorsal multidendritic neuron ddaC | third instar larval stage, with Scer\GAL4ppk.PG
abdominal dorsal multidendritic neuron ddaD | somatic clone | third instar larval stage
abdominal dorsal multidendritic neuron ddaD | third instar larval stage, with Scer\GAL4221
abdominal dorsal multidendritic neuron ddaE | somatic clone | third instar larval stage
abdominal dorsal multidendritic neuron ddaE | third instar larval stage, with Scer\GAL4221
abdominal intersegmental nerve
abdominal segmental nerve
abdominal segmental nerve, with Scer\GAL4elav.PLu
abdominal segmental nerve, with Scer\GAL4how-24B
abdominal segmental nerve, with Scer\GAL4twi.PG
adult abdomen
adult antennal lobe projection neuron | heat sensitive | somatic clone, with Scer\GAL4GH146
adult antennal lobe projection neuron | somatic clone
adult antennal lobe projection neuron | somatic clone, with Scer\GAL4GH146
adult antennal lobe projection neuron | somatic clone, with Scer\GAL4GH146, lola3.8.UAS
adult antennal lobe projection neuron | somatic clone, with Scer\GAL4GH146, lola4.7.UAS
adult antennal lobe projection neuron | somatic clone, with Scer\GAL4GH146, lolae76
adult antennal lobe projection neuron | somatic clone, with Scer\GAL4GH146, lolaL.UAS
adult antennal lobe projection neuron adPN | somatic clone, with Scer\GAL4GH146, lola3.8.UAS
adult antennal lobe projection neuron adPN | somatic clone, with Scer\GAL4GH146, lola4.7.UAS
adult antennal lobe projection neuron adPN | somatic clone, with Scer\GAL4GH146, lolae76
adult antennal lobe projection neuron adPN | somatic clone, with Scer\GAL4GH146, lolaL.UAS
adult antennal lobe projection neuron DA1 vPN
adult antennal lobe projection neuron DA1 vPN | somatic clone, with Scer\GAL4GH146, lola3.8.UAS
adult antennal lobe projection neuron DA1 vPN | somatic clone, with Scer\GAL4GH146, lola4.7.UAS
adult antennal lobe projection neuron DA1 vPN | somatic clone, with Scer\GAL4GH146, lolae76
adult antennal lobe projection neuron DA1 vPN | somatic clone, with Scer\GAL4GH146, lolaL.UAS
adult antennal lobe projection neuron DL1 adPN | cell autonomous | somatic clone
adult antennal lobe projection neuron DL1 adPN | somatic clone, with Scer\GAL4GH146, lola3.8.UAS
adult antennal lobe projection neuron DL1 adPN | somatic clone, with Scer\GAL4GH146, lola4.7.UAS
adult antennal lobe projection neuron DL1 adPN | somatic clone, with Scer\GAL4GH146, lolae76
adult antennal lobe projection neuron DL1 adPN | somatic clone, with Scer\GAL4GH146, lolaL.UAS
adult antennal lobe projection neuron lPN | somatic clone, with Scer\GAL4GH146, lola3.8.UAS
adult antennal lobe projection neuron lPN | somatic clone, with Scer\GAL4GH146, lola4.7.UAS
adult antennal lobe projection neuron lPN | somatic clone, with Scer\GAL4GH146, lolae76
adult antennal lobe projection neuron lPN | somatic clone, with Scer\GAL4GH146, lolaL.UAS
adult antennal lobe projection neuron VA1v vPN | somatic clone, with Scer\GAL4GH146, lola3.8.UAS
adult antennal lobe projection neuron VA1v vPN | somatic clone, with Scer\GAL4GH146, lola4.7.UAS
adult antennal lobe projection neuron VA1v vPN | somatic clone, with Scer\GAL4GH146, lolae76
adult antennal lobe projection neuron VA1v vPN | somatic clone, with Scer\GAL4GH146, lolaL.UAS
adult lateral horn | somatic clone
adult lateral horn | somatic clone, with Scer\GAL4GH146, lola3.8.UAS
adult lateral horn | somatic clone, with Scer\GAL4GH146, lola4.7.UAS
adult lateral horn | somatic clone, with Scer\GAL4GH146, lolae76
adult lateral horn | somatic clone, with Scer\GAL4GH146, lolaL.UAS
adult mushroom body | somatic clone
antennal lobe projection neuron adPN | cell autonomous | somatic clone
antennal lobe projection neuron lPN | cell autonomous | somatic clone
antennal lobe projection neuron vPN | cell autonomous | somatic clone
arista, with Scer\GAL4dpp.blk1
axon (with lolac46)
axon (with lolae76)
axon & adult antennal lobe projection neuron | somatic clone
axon & adult antennal lobe projection neuron | somatic clone, with Scer\GAL4GH146
axon & adult antennal lobe projection neuron | somatic clone, with Scer\GAL4GH146, lola4.7.UAS
axon & adult antennal lobe projection neuron | somatic clone, with Scer\GAL4GH146, lolae76
axon & adult antennal lobe projection neuron | somatic clone, with Scer\GAL4GH146, lolaL.UAS
axon & adult antennal lobe projection neuron | somatic clone | heat sensitive, with Scer\GAL4GH146
axon & larval antennal lobe projection neuron | somatic clone | penetrance incomplete | expressivity incomplete | cell autonomous
axon | embryonic stage
axon | embryonic stage, with Scer\GAL4elav-C155
central nervous system
chordotonal organ | lateral
commissure
cuticle | adult stage | female
dendrite & adult antennal lobe projection neuron | somatic clone
dendrite & adult antennal lobe projection neuron | somatic clone, with Scer\GAL4GH146
dendrite & adult antennal lobe projection neuron | somatic clone, with Scer\GAL4GH146, lola3.8.UAS
dendrite & adult antennal lobe projection neuron | somatic clone, with Scer\GAL4GH146, lola4.7.UAS
dendrite & adult antennal lobe projection neuron | somatic clone, with Scer\GAL4GH146, lolae76
dendrite & adult antennal lobe projection neuron | somatic clone, with Scer\GAL4GH146, lolaL.UAS
dendrite & adult antennal lobe projection neuron | somatic clone | heat sensitive, with Scer\GAL4GH146
dendrite & larval antennal lobe projection neuron | somatic clone | penetrance incomplete | expressivity incomplete | cell autonomous
dendritic tree | somatic clone | third instar larval stage
dendritic tree | third instar larval stage, with Scer\GAL4221
dendritic tree | third instar larval stage, with Scer\GAL4ppk.PG
dorsal appendage | germline clone
dorsocentral bristle, with Scer\GAL4sca-537.4
egg chamber | germline clone
embryonic/larval lymph gland, with Scer\GAL4HCH.Hand, Scer\GAL4Hml.Δ
embryonic/larval neuromuscular junction | embryonic stage
embryonic/larval somatic muscle
embryonic/larval somatic muscle (with Df(2R)ED2076)
eye, with Scer\GAL4hs.2sev
ganglion mother cell | larval stage
germline cell | embryonic stage
germline cell | embryonic stage (with Df(2R)BSC595)
germline cell | embryonic stage (with lola22.05)
germline cell | embryonic stage (with lola46.38)
germline cell | embryonic stage (with lolae76)
germline cell | embryonic stage (with lolaORC4)
gonad | embryonic stage
gonad | embryonic stage 14
gonad | embryonic stage (with Df(2R)BSC595)
gonad | embryonic stage (with lola22.05)
gonad | embryonic stage (with lola46.38)
gonad | embryonic stage (with lolaC28)
gonad | embryonic stage (with lolae76)
gonad | embryonic stage (with lolaORC4)
gonadal sheath proper primordium
gonadal sheath proper primordium (with lola22.05)
gonadal sheath proper primordium (with lola46.38)
gonadal sheath proper primordium (with lolae76)
gonadal sheath proper primordium (with lolaORC4)
gonadal sheath proper primordium | embryonic stage (with lola22.05)
gonadal sheath proper primordium | embryonic stage (with lola46.38)
intersegmental nerve
intersegmental nerve branch ISNb of A1-7 | embryonic stage
larval dorsal multidendritic neuron ddaC, with Scer\GAL4ppk.1.9
larval dorsal multidendritic neuron ddaD, with Scer\GAL4221
larval dorsal multidendritic neuron ddaE, with Scer\GAL4221
larval neuroblast | larval stage
larval ventral multidendritic neuron vdaB, with Scer\GAL4ppk.1.9
leg
longitudinal connective
macrochaeta
mesothoracic tergum, with Scer\GAL4pnr-MD237
neuroblast | third instar larval stage, with Avic\GFPdsRNA.shRNA.UAS.V20.1, Scer\GAL4wor.PA
neuroblast | third instar larval stage, with Avic\GFPdsRNA.shRNA.UAS.V20.1, Scer\GAL4wor.PA, lolaV5.miGFPi.PB/lolaV5.miGFPi.all
neuroblast | third instar larval stage (with lolaV5.miGFPi.all), with Avic\GFPdsRNA.shRNA.UAS.V20.1, Scer\GAL4wor.PA, lolaHA.miGFPi.PD
neuroblast | third instar larval stage (with lolaV5.miGFPi.PB), with Avic\GFPdsRNA.shRNA.UAS.V20.1, Scer\GAL4wor.PA, lolaHA.miGFPi.PD
nurse cell | germline clone
presumptive embryonic/larval central nervous system
presumptive embryonic/larval peripheral nervous system
scutellar bristle, with Scer\GAL4sca-537.4
synapse, with Scer\GAL4how-24B
synapse, with Scer\GAL4twi.PG
tormogen cell, with Scer\GAL4sca-537.4
trichogen cell, with Scer\GAL4pnr-MD237
type II neuroblast | larval stage, with Scer\GAL4insc-Mz1407
type I neuroblast | larval stage, with Scer\GAL4insc-Mz1407
ventral longitudinal muscle
ventral midline of embryo | embryonic stage
ventral nerve cord | embryonic stage, with Scer\GAL4elav-C155
VUM4 interneuron
VUM5 interneuron
VUM6 interneuron
VUM neuron
wing | male limited, with Scer\GAL4Bx-MS1096
wing | posterior, with Scer\GAL4en-e16E
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (3)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\BTBD18
2 of 15
Yes
No
Hsap\DNAJC14
1 of 15
No
No
Hsap\ZBTB20
1 of 15
No
Yes
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (3)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Btbd18
1 of 15
Yes
Yes
Mmus\Dnajc14
1 of 15
Yes
No
Mmus\Zfp219
1 of 15
Yes
Yes
Rattus norvegicus (Norway rat) (3)
Rnor\Btbd18
1 of 13
Yes
No
Rnor\Dnajc14
1 of 13
Yes
No
Rnor\Zbtb17
1 of 13
Yes
Yes
Xenopus tropicalis (Western clawed frog) (1)
Xtro\btbd18
1 of 12
Yes
Yes
Danio rerio (Zebrafish) (2)
Drer\btbd18
1 of 15
Yes
Yes
Drer\dnajc14
1 of 15
Yes
No
Caenorhabditis elegans (Nematode, roundworm) (1)
Cele\R09A1.2
1 of 15
Yes
Yes
Arabidopsis thaliana (thale-cress) (2)
Atha\EDA31
1 of 9
Yes
No
Atha\PTL
1 of 9
Yes
No
Saccharomyces cerevisiae (Brewer's yeast) (2)
Scer\CYK3
1 of 15
Yes
No
Scer\QDR3
1 of 15
Yes
Yes
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG0919048Y )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila simulans
Dsim\lola
Drosophila sechellia
Dsec\GM20511
Drosophila erecta
Dere\GG22728
Drosophila yakuba
Dyak\GE13086
Drosophila pseudoobscura pseudoobscura
Dpse\GA30442
Drosophila persimilis
Dper\GL17192
Drosophila willistoni
Dwil\GK10674
Drosophila virilis
Dvir\GJ20132
Drosophila mojavensis
Dmoj\GI20175
Drosophila grimshawi
Dgri\GH20621
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091502DI )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17016246
Glossina morsitans
Tsetse fly
Gmor\GMOY001502
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W024W )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA004640
Bombyx mori
Silkmoth
Bmor\BGIBMGA000147
Danaus plexippus
Monarch butterfly
Dple\DPOGS212369-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS212370-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS212372-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL005659
Apis florea
Little honeybee
Aflo\2147516899
Apis florea
Little honeybee
Aflo\2160356322
Apis florea
Little honeybee
Aflo\2179251524
Apis florea
Little honeybee
Aflo\2147517011
Apis florea
Little honeybee
Aflo\2179256228
Apis florea
Little honeybee
Aflo\2163774642
Apis florea
Little honeybee
Aflo\2147516787
Apis florea
Little honeybee
Aflo\2147516867
Apis florea
Little honeybee
Aflo\2179256324
Apis mellifera
Western honey bee
Amel\GB53490
Apis mellifera
Western honey bee
Amel\GB53458
Apis mellifera
Western honey bee
Amel\GB53479
Apis mellifera
Western honey bee
Amel\GB53441
Apis mellifera
Western honey bee
Amel\GB53471
Apis mellifera
Western honey bee
Amel\GB53463
Apis mellifera
Western honey bee
Amel\GB53480
Apis mellifera
Western honey bee
Amel\GB53470
Apis mellifera
Western honey bee
Amel\GB53487
Apis mellifera
Western honey bee
Amel\GB53474
Apis mellifera
Western honey bee
Amel\GB53478
Apis mellifera
Western honey bee
Amel\GB53488
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP25400
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP25395
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP25389
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP25399
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP25398
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP25379
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP25402
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP25394
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP25377
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP25401
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP25404
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP25393
Bombus terrestris
Buff-tailed bumblebee
Bter\15207371
Bombus terrestris
Buff-tailed bumblebee
Bter\15207841
Bombus terrestris
Buff-tailed bumblebee
Bter\15201497
Linepithema humile
Argentine ant
Lhum\LH20239
Linepithema humile
Argentine ant
Lhum\LH20251
Linepithema humile
Argentine ant
Lhum\LH20249
Linepithema humile
Argentine ant
Lhum\LH25862
Linepithema humile
Argentine ant
Lhum\LH25863
Linepithema humile
Argentine ant
Lhum\LH25832
Linepithema humile
Argentine ant
Lhum\LH20241
Linepithema humile
Argentine ant
Lhum\LH25820
Linepithema humile
Argentine ant
Lhum\LH25818
Linepithema humile
Argentine ant
Lhum\LH20224
Linepithema humile
Argentine ant
Lhum\LH25826
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:0027e3
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:0027e2
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:0027e1
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:0027e5
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG001781
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG001850
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG001759
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG001780
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG001811
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG001727
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG001757
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG036900
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG001730
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_08517
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_09787
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_09790
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_09794
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_09789
Tribolium castaneum
Red flour beetle
Tcas\TC033327
Tribolium castaneum
Red flour beetle
Tcas\TC032327
Tribolium castaneum
Red flour beetle
Tcas\TC032328
Tribolium castaneum
Red flour beetle
Tcas\TC015631
Tribolium castaneum
Red flour beetle
Tcas\TC015600
Tribolium castaneum
Red flour beetle
Tcas\TC009434
Tribolium castaneum
Red flour beetle
Tcas\TC006257
Tribolium castaneum
Red flour beetle
Tcas\TC003099
Tribolium castaneum
Red flour beetle
Tcas\TC031294
Tribolium castaneum
Red flour beetle
Tcas\TC005828
Tribolium castaneum
Red flour beetle
Tcas\TC033326
Tribolium castaneum
Red flour beetle
Tcas\TC034122
Tribolium castaneum
Red flour beetle
Tcas\TC003827
Tribolium castaneum
Red flour beetle
Tcas\TC015075
Tribolium castaneum
Red flour beetle
Tcas\TC006256
Tribolium castaneum
Red flour beetle
Tcas\TC015072
Tribolium castaneum
Red flour beetle
Tcas\TC015515
Tribolium castaneum
Red flour beetle
Tcas\TC032329
Tribolium castaneum
Red flour beetle
Tcas\TC009433
Tribolium castaneum
Red flour beetle
Tcas\TC005755
Tribolium castaneum
Red flour beetle
Tcas\TC005888
Pediculus humanus
Human body louse
Phum\PHUM449150
Pediculus humanus
Human body louse
Phum\PHUM149730
Pediculus humanus
Human body louse
Phum\PHUM181730
Pediculus humanus
Human body louse
Phum\PHUM449380
Pediculus humanus
Human body louse
Phum\PHUM397830
Rhodnius prolixus
Kissing bug
Rpro\RPRC000686
Rhodnius prolixus
Kissing bug
Rpro\RPRC006140
Rhodnius prolixus
Kissing bug
Rpro\RPRC006135
Rhodnius prolixus
Kissing bug
Rpro\RPRC006120
Rhodnius prolixus
Kissing bug
Rpro\RPRC006133
Rhodnius prolixus
Kissing bug
Rpro\RPRC012966
Rhodnius prolixus
Kissing bug
Rpro\RPRC006142
Rhodnius prolixus
Kissing bug
Rpro\RPRC013000
Rhodnius prolixus
Kissing bug
Rpro\RPRC010110
Rhodnius prolixus
Kissing bug
Rpro\RPRC014104
Rhodnius prolixus
Kissing bug
Rpro\RPRC014107
Rhodnius prolixus
Kissing bug
Rpro\RPRC012976
Rhodnius prolixus
Kissing bug
Rpro\RPRC006117
Rhodnius prolixus
Kissing bug
Rpro\RPRC006158
Rhodnius prolixus
Kissing bug
Rpro\RPRC006154
Rhodnius prolixus
Kissing bug
Rpro\RPRC010114
Cimex lectularius
Bed bug
Clec\CLEC008582
Cimex lectularius
Bed bug
Clec\CLEC008551
Cimex lectularius
Bed bug
Clec\CLEC008517
Cimex lectularius
Bed bug
Clec\CLEC008576
Cimex lectularius
Bed bug
Clec\CLEC008600
Cimex lectularius
Bed bug
Clec\CLEC008580
Cimex lectularius
Bed bug
Clec\CLEC005934
Cimex lectularius
Bed bug
Clec\CLEC008553
Cimex lectularius
Bed bug
Clec\CLEC008601
Cimex lectularius
Bed bug
Clec\CLEC008596
Cimex lectularius
Bed bug
Clec\CLEC008547
Cimex lectularius
Bed bug
Clec\CLEC025019
Cimex lectularius
Bed bug
Clec\CLEC008521
Cimex lectularius
Bed bug
Clec\CLEC025019-PB
Cimex lectularius
Bed bug
Clec\CLEC008559
Cimex lectularius
Bed bug
Clec\CLEC008526
Cimex lectularius
Bed bug
Clec\CLEC008502
Cimex lectularius
Bed bug
Clec\CLEC008587
Cimex lectularius
Bed bug
Clec\CLEC008512
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI006424
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI001667
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI55348
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI39689
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI061058
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI009795
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI073012
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI083996
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI006491
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI50167
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI072207
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI063216
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI38046
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI38043
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI061694
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_08900
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_08907
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_08898
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_17751
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0L95 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Ixodes scapularis
Black-legged tick
Isca\ISCW016356
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_313525
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0WNB )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Z415
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Z304
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000009559
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (25)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
ab
2 of 10
bab1
2 of 10
bab2
2 of 10
br
2 of 10
BtbVII
2 of 10
CG3726
2 of 10
CG6118
2 of 10
CG8924
2 of 10
CG12236
2 of 10
CG32121
2 of 10
CG34376
2 of 10
chinmo
2 of 10
fru
2 of 10
lov
2 of 10
mamo
2 of 10
mod(mdg4)
2 of 10
psq
2 of 10
rib
2 of 10
Trl
2 of 10
ttk
2 of 10
CG1812
1 of 10
CG6765
1 of 10
CG15812
1 of 10
lolal
1 of 10
pre-lola-G
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
Disease Model Summary Ribbon
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 1 )
Allele
Disease
Evidence
References
lolaGS88A8
model of  cancer
CEA with DlUAS.cDa, psqGS88A8
(Bossuyt et al., 2009, Ferres-Marco et al., 2006)
Potential Models Based on Orthology ( 0 )
Human Ortholog
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 1 )
Allele
Disease
Interaction
References
lolaKK110256
exacerbates  retinitis pigmentosa
modeled by ninaEG69D.UAS
(Chow et al., 2016)
Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Homo sapiens (Human)
Gene name
Score
OMIM
OMIM Phenotype
DO term
Complementation?
Transgene?
Functional Complementation Data
Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
Interactions
Summary of Physical Interactions
esyN Network Diagram
Show neighbor-neighbor interactions:
Select Layout:
Legend:
Protein
RNA
Selected Interactor(s)
Interactions Browser
View in Interactions Browser
Please see the Physical Interaction reports below for full details
protein-protein
Physical Interaction
Assay
References
lola
pull down, tag visualisation, anti bait coimmunoprecipitation, western blot, two hybrid
(Silva et al., 2016, Kazemian et al., 2013, Zhang et al., 2003)
lola - CG32121
bimolecular fluorescence complementation, fluorescence microscopy, two hybrid array
(Shokri et al., 2019)
lola - CkIIα-i3
two hybrid
(Hu et al., 2017.6.13)
lola - Hr78
two hybrid array
(Shokri et al., 2019)
lola - JIL-1
two hybrid, anti bait coimmunoprecipitation, western blot, pull down
(Zhang et al., 2003)
lola - Trl
two hybrid, anti bait coimmunoprecipitation, Identification by mass spectrometry
(Lomaev et al., 2017)
lola - for
anti tag coimmunoprecipitation, anti tag western blot, western blot
(Peng et al., 2016)
lola - fru
anti tag coimmunoprecipitation, anti tag western blot, western blot
(Sato et al., 2019)
lola - osk
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Hurd et al., 2016)
lola - rib
two hybrid
(Silva et al., 2016)
lola - sima
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
lola - wts
anti tag coimmunoprecipitation, anti tag western blot
(Hao et al., 2020)
RNA-protein
Physical Interaction
Assay
References
lola - B52
systematic evolution of ligands by exponential enrichment, full identification by DNA sequencing, electrophoretic mobility shift assay, autoradiography
(Kim et al., 2003)
Summary of Genetic Interactions
esyN Network Diagram
esyN Network Key:
Suppression
Enhancement
View in Interactions Browser
Please look at the allele data for full details of the genetic interactions
Starting gene(s)
Interaction type
Interacting gene(s)
Reference
lola|psq|Dl
enhanceable
ato
(Bossuyt et al., 2009)
Dl|lola|psq
suppressible
ato
(Bossuyt et al., 2009)
lola|psq|Dl
enhanceable
bsk
(Bossuyt et al., 2009)
Dl|lola|psq
enhanceable
ct
(Zhai et al., 2012)
lola|psq|Dl
enhanceable
ct
(Zhai et al., 2012)
Dl|lola|psq
suppressible
dap
(Bossuyt et al., 2009)
Dl|lola|psq
suppressible
E(z)
(Ferres-Marco et al., 2006)
lola
suppressible
for
(Peng et al., 2016)
lola
suppressible
futsch
(Dinges et al., 2017)
Dl|lola|psq
suppressible
HDAC1
(Ferres-Marco et al., 2006)
Dl|lola|psq
suppressible
Ilp8
(Garelli et al., 2012)
Dl|lola|psq
suppressible
Jra
(Bossuyt et al., 2009)
Dl|lola|psq
suppressible
mir-8
(Vallejo et al., 2011)
lola|psq|Dl
enhanceable
mirr
(Barrios et al., 2015)
Dl|lola|psq
suppressible
Not3
(Vicente et al., 2018)
Dl|lola|psq
suppressible
Rbf
(Ferres-Marco et al., 2006)
lola|psq|Dl
enhanceable
Rbf
(Ferres-Marco et al., 2006)
lola
enhanceable
rib
(Silva et al., 2016)
lola
enhanceable
robo1
(Crowner et al., 2002)
lola
enhanceable
sli
(Crowner et al., 2002)
Dl|lola|psq
suppressible
Su(var)3-9
(Ferres-Marco et al., 2006)
lola
suppressible
Tbh
(Dinges et al., 2017)
lola|psq|Dl
enhanceable
Utx
(Herz et al., 2010)
Starting gene(s)
Interaction type
Interacting gene(s)
Reference
ct
suppressible
lola
(Krupp et al., 2005)
ct
enhanceable
lola
(Krupp et al., 2005)
dom
enhanceable
lola
(Kwon et al., 2013)
for
suppressible
lola
(Peng et al., 2016)
gcm
suppressible
lola
(Popkova et al., 2012)
H
enhanceable
lola
(Müller et al., 2005)
JIL-1
suppressible
lola
(Zhang et al., 2003)
kn
suppressible
lola
(Hattori et al., 2013)
mam
enhanceable
lola
(Kwon et al., 2013)
N
suppressible
lola
(Djiane et al., 2013)
N
enhanceable
lola
(Verheyen et al., 1996)
ninaE
enhanceable
lola
(Chow et al., 2016)
Nsf2
suppressible
lola
(Laviolette et al., 2005)
pbl
enhanceable
lola
(Gregory et al., 2007)
Rbf
enhanceable
lola
(Kwon et al., 2013)
rib
enhanceable
lola
(Silva et al., 2016)
External Data
Subunit Structure (UniProtKB)
Isoform D interacts with JIL-1.
(UniProt, Q7KQZ4 )
Linkouts
BioGRID - A database of protein and genetic interactions.
InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
MIST (genetic) - An integrated Molecular Interaction Database
MIST (protein-protein) - An integrated Molecular Interaction Database
Pathways
Signaling Pathways (FlyBase)
Positive Regulators of Imd Signaling Pathway -
Positive regulators of the immune deficiency (Imd) pathway result in the increased activity of the NFκB-like transcription factor Rel in the nucleus. (Adapted from FBrf0224587 and FBrf0238555.)
Metabolic Pathways
External Data
Linkouts
Genomic Location and Detailed Mapping Data
Chromosome (arm)
2R
Recombination map

2-62

Cytogenetic map
47A11-47A13
Sequence location
2R:10,481,894..10,543,291 [-]
FlyBase Computed Cytological Location
Cytogenetic map
Evidence for location
47A11-47A13
Limits computationally determined from genome sequence between P{lacW}Hr46k10308 and P{PZ}lola00349&P{EP}lolaEP952
Experimentally Determined Cytological Location
Cytogenetic map
Notes
References
47A-47B14
(determined by in situ hybridisation)
(Prokopenko et al., 2000)
Location based on in situ hybridisation using flanking plasmid rescue sequence from the P{lacW}btbk09901 insertion.
(Prokopenko et al., 2000)
47A13-47A13
(determined by in situ hybridisation)
(Abdelilah-Seyfried et al., 2000)
47A-47A
(Laski, 1994.9.5)
47A11-47A12
(determined by in situ hybridisation)
(Spradling et al., 1999)
47A13-47A16
(determined by in situ hybridisation)
(Berg, 1996.2.28)
47A-47B
(determined by in situ hybridisation)
(Kania et al., 1995)
47A9-47A14
(determined by in situ hybridisation)
(Giniger et al., 1994)
47A11-47B14
(BDGP Project Members, 1994-1999)
47A11-47A14
(determined by in situ hybridisation)
(Seeger et al., 1993)
Experimentally Determined Recombination Data
Location

2-62

(FlyBase, 2016)

2-61.2

(Comeron et al., 2012)

2-

(Laski, 1994.9.5)
Left of (cM)
Right of (cM)
Notes
Stocks and Reagents
Stocks (72)
Genomic Clones (32)
cDNA Clones (722)
 

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced
BDGP DGC clones
Other clones
Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones
Other clones
RNAi and Array Information
Linkouts
Antibody Information
Laboratory Generated Antibodies
 

polyclonal

(Hao et al., 2020, Sato et al., 2019, Zhang et al., 2003, Giniger et al., 1994)
Commercially Available Antibodies
 
Developmental Studies Hybridoma Bank - Monoclonal antibodies for use in research
Other Information
Relationship to Other Genes
Source for database identify of
Source for database merge of

Source for merge of: lola BcDNA:RH31485

(FlyBase, 1996-)

Source for merge of: lola BtbIV

(FlyBase, 1996-)

Source for merge of: lola l(2)s3697

(Beaton, 1999.12.12)

Source for merge of: lola CG12052 CG18376

(Bayraktaroglu, 2000.4.12)

Source for merge of: lola sw59 BEST:LD03274

(Bayraktaroglu, 2000.11.2)

Source for merge of: lola NEST:bs06a08

(FlyBase, 1996-)

Source for merge of: lola CG18378 CG18379 CG18380 CG18381

(FlyBase Genome Annotators, 2002-2003)

Source for merge of: lola btb

(Bass et al., 2007)
Additional comments

snoRNA:lola-a, snoRNA:lola-b, snoRNA:lola-c and snoRNA:lola-d are encoded in an intron of lola.

(Graveley et al., 2011)

btb[k09901] shows nervous system defects similar to alleles of lola. It also fails to complement several lola alleles, including lola00642, lola5D2, lolaORC4, lolaORE50, lola4E4 and lolaORE120. Previous papers (FBrf0131381) have shown that btb[k09901] complements other alleles of lola, however, lola alleles are known to show intragenic complementation, which can be explained by the trans-splicing that occurs at the lola locus (FBrf0167601). Thus, overall the available evidence indicates that btb[k09901] is an allele of lola.

(Bass et al., 2007)

Source for merge of: lola BcDNA:LD17006

(Ferres-Marco et al., 2006, FlyBase, 1996-)

Annotations CG18376, CG18381, CG18380, CG18379, CG18378 and CG12052 merged as CG12052 in release 3 of the genome annotation.

(FlyBase Genome Annotators, 2002-2003)

Source for merge of lola BtbIV was sequence comparison ( date:000202 ).

(FlyBase, 1996-)

Source for merge of lola BcDNA:LD17006 was a shared cDNA ( date:030728 ).

(FlyBase, 1996-)

The insertion has consistently been shown to map to 47A--47B by in situ hybridization (FBrf0080145, FBrf0131381), consistent with the location of lola (47A). However, the flanking sequences reported in FBrf0131381 (AF175907 and AF175908) map to 94A. Sequencing of the line by the GDP in 2009 (GSS sequences KS308221 and KS308220, reported in FBrf0230166) places the insertion at 2R:10534369 (minus strand) (genome release 6 coordinates). This is within the lola gene, consistent with the in situ localization data and supporting the hypothesis of FBrf0194763 that l(2)k09901 is a lola allele.

(FlyBase, 1992-)

The available evidence therefore suggests that the l(2)k09901 line is an allele of lola. Thus the 'btb, bumper-to-bumper' gene (of which l(2)k09901 is the only allele) has been merged with the lola gene and the btb[k09901] allele has been renamed lola[k09901] in FlyBase (date: 2015.10.22).

(FlyBase, 1992-)

There have been conflicting results in the literature regarding the location and allelism of the l(2)k09901 insertion line.

(FlyBase, 1992-)

FBrf0194763 hypothesised that the l(2)k09901 insertion line is an allele of lola, based on its failure to complement several alleles of lola. In contrast, FBrf0080145 and FBrf0131381 report complementation between l(2)k09901 and lola alleles. As discussed in FBrf0194763, intragenic complementation between other lola alleles has been seen previously (FBrf0167601) and can be explained by the trans-splicing that occurs at the lola locus (FBrf0167601), thus reconciling these apparently conflicting complementation results.

(FlyBase, 1992-)
Other Comments

lola is required to regulate stem cell differentiation in type II neural stem cells in the larval central brain.

(Wissel et al., 2016)

ChEST reveals this is a target of Mef2.

(Junion et al., 2005)

RNAi screen using dsRNA made from templates generated with primers directed against this gene causes a specific decrease in AttA activity in response to heat-killed E.coli when assayed in S2 cells.

(Kleino et al., 2005)

RNAi generated by PCR using primers directed to this gene causes a cell growth and viability phenotype when assayed in Kc167 and S2R+ cells.

(Boutros et al., 2004)

lola mRNAs are generated by alternative trans-splicing.

(Horiuchi et al., 2003)

Identification: as a suppressor of the small eye phenotype caused by overexpression of fng in the eye.

(Ferres-Marco and Dominguez, 2001)

'eyeful' mutant interacts genetically with N and fng though it is not yet clear whether 'eyeful' corresponds to lola or psq.

(Ferres-Marco and Dominguez, 2001)

Five EMS induced alleles have been identified in a screen for mutations affecting commissure formation in the CNS of the embryo.

(Hummel et al., 1999)

Homozygous germline clones have not been recovered. lola may perform some essential function in the germline during oogenesis.

(Madden et al., 1999)

lola is required for required for pathfinding and targeting of the SNb motor nerve. lola is a dose dependant regulator of SNb development.

(Madden et al., 1999)

Identification: Enhancer trap screen designed to discover genes involved in the cellular aspects of defense mechanisms, as well as in melanotic tumor formation processes linked to blood cell disregulation.

(Braun et al., 1997)

Dhyd\lola-like is structurally related to lola.

(Cavarec et al., 1997)

lola encodes a transcription factor required for axon growth and guidance in the embryo.

(Giniger et al., 1994)

In lola mutant embryos growth cones that normally pioneer longitudinal pathways initially extend but then stall, thereby lacking most longitudinal axon pathways.

(Goodman et al., 1993)

Mutations lack longitudinal connectives of embryonic ventral nerve cord.

(Seeger et al., 1993)
Origin and Etymology
Discoverer
Etymology
Identification
External Crossreferences and Linkouts ( 374 )
Sequence Crossreferences
NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
Other crossreferences
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
InterPro - A database of protein families, domains and functional sites
KEGG Genes - Molecular building blocks of life in the genomic space.
Linkouts
BioGRID - A database of protein and genetic interactions.
Developmental Studies Hybridoma Bank - Monoclonal antibodies for use in research
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
MIST (genetic) - An integrated Molecular Interaction Database
MIST (protein-protein) - An integrated Molecular Interaction Database
Synonyms and Secondary IDs (36)
Reported As
Symbol Synonym
BEST:LD03274
BTB-IV
(Laski, 1994.9.5, Zollman et al., 1994)
BcDNA:LD17006
BcDNA:RH31485
BtbIV
CG12052
(Lomaev et al., 2017, Çiçek et al., 2016, Hurd et al., 2016, Hosono et al., 2015, Sing et al., 2014, Schertel et al., 2013, Aoki et al., 2012, Hadar et al., 2012, Ni et al., 2011.7.19, Zheng et al., 2011, Bossuyt et al., 2009, Keleman et al., 2009.8.5, Perkins et al., 2009.3.31, Strub et al., 2008, Quinones-Coello, 2007, Kleino et al., 2005, Laviolette et al., 2005, Norga et al., 2003, Ramet et al., 2002, Stempfl et al., 2002)
CG18376
CG18378
(Ohsako et al., 2003, Brody et al., 2002, Stempfl et al., 2002)
CG18379
(Ohsako et al., 2003)
CG18380
CG18381
(Boutros et al., 2004, Ohsako et al., 2003)
CG30012
(Ohsako et al., 2003)
CG30013
CG30014
LD03274
(Toba et al., 1999)
Lola
(Hassan et al., 2020, Sato et al., 2019, Casas-Vila et al., 2017, Lomaev et al., 2017, Chaharbakhshi and Jemc, 2016, Barrios et al., 2015, Kanoh et al., 2015, Ferrero et al., 2014, Chintapalli et al., 2013, Gisselbrecht et al., 2013, Puram and Bonni, 2013, Kelsom and Lu, 2012, Tokusumi et al., 2012, Bonchuk et al., 2011, Liefke et al., 2010, Wagner et al., 2007, Wagner et al., 2007)
NEST:bs06a08
bs06a08.y1
(Oliver, 2001.8.16)
btb
(Bass et al., 2007)
eyeful
(Ferres-Marco et al., 2006, Ferres-Marco and Dominguez, 2001)
fus7
(Weyers et al., 2011)
l(2)00642
(Braun et al., 1997)
l(2)s3697
(BDGP Project Members, 1994-1999)
lola
(Bravo González-Blas et al., 2020, Cho et al., 2020, Gilbert et al., 2020, Hao et al., 2020, Hung et al., 2020, Keder et al., 2020, Lecheta et al., 2020, Lepesant et al., 2020, Şahin et al., 2020, Camus et al., 2019, Chai et al., 2019, Hall et al., 2019, Hope et al., 2019, Rivera et al., 2019, Sato et al., 2019, Shokri et al., 2019, Yang et al., 2019, Bischof et al., 2018, Katanaev et al., 2018, Lee et al., 2018, Tokusumi et al., 2018, Troha et al., 2018, Ugrankar et al., 2018, Bonneaud et al., 2017, Dinges et al., 2017, Hu et al., 2017.6.13, Alavi et al., 2016, Chow et al., 2016, Froldi and Cheng, 2016, Gene Disruption Project members, 2016-, Hunter et al., 2016, Kockel et al., 2016, Mishra et al., 2016, Peng et al., 2016, Quijano et al., 2016, Silva et al., 2016, Angrisani et al., 2015, Baëza et al., 2015, Dorn and Dorn, 2015, Gao et al., 2015, Kavi et al., 2015, Nadimpalli et al., 2015, Ríos-Barrera et al., 2015, Schertel et al., 2015, Ugrankar et al., 2015, Zhang et al., 2015, Ashwal-Fluss et al., 2014, Bonnay et al., 2014, Boyle et al., 2014, Chen et al., 2014, Dobi et al., 2014, Fedotov et al., 2014, Ferreira et al., 2014, Mondal et al., 2014, Neville et al., 2014, Slattery et al., 2014, Southall et al., 2014, Tripathy et al., 2014, Zarin et al., 2014, Brown et al., 2013, Daneshvar et al., 2013, Davies et al., 2013, Djiane et al., 2013, Enuameh et al., 2013, Hattori et al., 2013, Iyer et al., 2013, Kwon et al., 2013, Kwon et al., 2013, Schertel et al., 2013, Shen et al., 2013, Spokony and White, 2013.5.10, Wang et al., 2013, Aoki et al., 2012, Bartoletti et al., 2012, Berger et al., 2012, Fukui et al., 2012, Garcia et al., 2012, Hadar et al., 2012, Japanese National Institute of Genetics, 2012.5.21, Popkova et al., 2012, Rodriguez et al., 2012, Spokony and White, 2012.5.22, Takahashi et al., 2012, Zhai et al., 2012, Abruzzi et al., 2011, Bonchuk et al., 2011, Friedman et al., 2011, Graveley et al., 2011, Grimberg et al., 2011, Jayanandanan et al., 2011, Kazemian et al., 2011, Miles et al., 2011, Neumüller et al., 2011, Sameny and Locke, 2011, Seong et al., 2011, Toku et al., 2011, Vallejo et al., 2011, Waldholm et al., 2011, Weyers et al., 2011, Zheng et al., 2011, Baig et al., 2010, Blanco et al., 2010, Buffin and Gho, 2010, Cunha et al., 2010, Foley et al., 2010, Gan et al., 2010, Kim and Marqués, 2010, McManus et al., 2010, Potter et al., 2010, Rouault et al., 2010, Silicheva et al., 2010, Ayroles et al., 2009, Bossuyt et al., 2009, Carreira et al., 2009, Krejcí et al., 2009, Moran and Kyriacou, 2009, Otte et al., 2009, Shalaby et al., 2009, Southall and Brand, 2009, Tsubouchi et al., 2009, Wheeler et al., 2009, Yamamoto et al., 2009, Christensen et al., 2008.9.3, Strub et al., 2008, Yamamoto et al., 2008, Zheng and Carthew, 2008, Bass and McCall, 2007, Bass et al., 2007, Buszczak et al., 2007, Gregory et al., 2007, Magalhaes et al., 2007, Maines et al., 2007, Minidorff et al., 2007, Morozova et al., 2007, Mukai et al., 2007, Nurminsky, 2007, Quinones-Coello, 2007, Spletter et al., 2007, Spletter et al., 2007, Spokony and Restifo, 2007, Axelson, 2006, Dorus et al., 2006, Edwards et al., 2006, Haynes et al., 2006, Morozova et al., 2006, Zhang et al., 2006, Laviolette et al., 2005, Dimitri et al., 2003, Goeke et al., 2003, Klebes et al., 2002)
sw59
Name Synonyms
BTB-protein-IV
Longitudinal lacking
(Froldi and Cheng, 2016)
Longitudinals lacking
(Otte et al., 2009)
SGP cluster fusion defects 7
(Weyers et al., 2011)
bumper-to-bumper
(Bass et al., 2007)
e
(Baig et al., 2010)
eyeful
(Liefke et al., 2010)
lola
(Tokusumi et al., 2018, Biehs et al., 2010, Herz et al., 2010)
longitudinal lacking
(Axelson, 2006, Girard et al., 2006)
longitudinals absent
(Baker et al., 2001)
longitudinals lacking
(Tokusumi et al., 2017, Kanoh et al., 2015, Davies et al., 2013, Iyer et al., 2013, Shen et al., 2013, Berger et al., 2012, Felix et al., 2012, Fukui et al., 2012, Miles et al., 2011, Weyers et al., 2011, Buffin and Gho, 2010, Carreira et al., 2009, Edwards et al., 2009, Moran and Kyriacou, 2009, Shalaby et al., 2009, Yamamoto et al., 2009, Yamamoto et al., 2008, Davies et al., 2007, Morozova et al., 2007, Robin et al., 2007, Spletter et al., 2007, Spokony and Restifo, 2007, Edwards et al., 2006, Goeke et al., 2003)
longitudinals-lacking
(Bass et al., 2007)
misguided
(Guillemin et al., 1997)
Secondary FlyBase IDs
  • FBgn0005630
  • FBgn0010468
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