FlyBase Gene Report: Dmel\elgi

General Information

Symbol

Dmel\elgi

Species

D. melanogaster

Name

early girl

Annotation Symbol

CG17033

Feature Type

protein_coding_gene

FlyBase ID

FBgn0283649

Gene Model Status

Current

Stock Availability

11 publicly available

Gene Summary

early girl (elgi) encodes a myosin binding protein involved in the regulation of meiosis and Fat signaling pathway. [Date last reviewed: 2019-06-27] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
Interactive Fly

Also Known As

Nrdp1, dNrdp1

Key Links

Genomic Location

Cytogenetic map

72B2-72C1

Sequence location

3L:15,956,550..15,958,433 [+]

Recombination map

3-43

RefSeq locus

NT_037436 REGION:15956550..15958433

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (12 terms)

Molecular Function (5 terms)

Terms Based on Experimental Evidence (3 terms)

CV Term

Evidence

References

enables myosin binding

inferred from physical interaction with FLYBASE:Myo10A; FB:FBgn0263705

(Liu et al., 2008)

enables protein binding

inferred from physical interaction with UniProtKB:B5RJR1

(Misra and Irvine, 2019)

enables ubiquitin protein ligase activity

inferred from direct assay

(Misra and Irvine, 2019)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

enables ubiquitin protein ligase activity

inferred from electronic annotation with InterPro:IPR015036

(InterPro Project Members, 2004-)

enables ubiquitin-protein transferase activity

inferred from sequence or structural similarity with HGNC:18401

(Gene Ontology Curators, 2002-)

enables zinc ion binding

inferred from sequence model

(Ying et al., 2011)

Biological Process (6 terms)

Terms Based on Experimental Evidence (4 terms)

CV Term

Evidence

References

involved_in imaginal disc-derived wing vein morphogenesis

inferred from mutant phenotype

(Misra and Irvine, 2019)

acts_upstream_of positive regulation of hippo signaling

inferred from mutant phenotype

(Misra and Irvine, 2019)

involved_in regulation of meiotic cell cycle

inferred from mutant phenotype

(Von Stetina et al., 2008)

involved_in wing disc development

inferred from mutant phenotype

(Misra and Irvine, 2019)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

involved_in protein polyubiquitination

inferred from sequence or structural similarity with HGNC:18401

(Gene Ontology Curators, 2002-)

involved_in protein ubiquitination

inferred from electronic annotation with InterPro:IPR015036

(InterPro Project Members, 2004-)

Cellular Component (1 term)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

located_in cytoplasm

inferred from direct assay

(Misra and Irvine, 2019)

Terms Based on Predictions or Assertions (0 terms)

Gene Group (FlyBase)

UNCLASSIFIED RING DOMAIN UBIQUITIN LIGASES

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Snapshot

early girl (elgi) encodes a myosin binding protein involved in the regulation of meiosis and Fat signaling pathway. [Date last reviewed: 2019-06-27]

Gene Group (FlyBase)

UNCLASSIFIED RING DOMAIN UBIQUITIN LIGASES -: This group comprises RING domain ubiquitin ligases that do not classify under other groups in FlyBase.

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\elgi for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9VUV7)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.46

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

elgi-RA

FBtr0075510

NM_140559

1611

315

elgi-RB

FBtr0333573

NM_001274975

1534

315

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

elgi-PA

FBpp0075265

36.1

315

6.68

FBpp0305750

36.1

315

6.68

Q9VUV7

NP_001261904

AGB94597

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

315 aa isoforms: elgi-PA, elgi-PB

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\elgi using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

4.63

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 4 -- 6

organism

(Fisher et al., 2012)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in cytoplasm

inferred from direct assay

(Misra and Irvine, 2019)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\elgi in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\elgi

View exonic expression by tissue for Dmel\elgi

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0036546

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

39735/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0283649

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0036546

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0283649

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG17033

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 5 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 10 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of elgi

Transgenic constructs containing regulatory region of elgi

Aberrations (Deficiencies and Duplications) ( 1 )

Inferred from experimentation ( 1 )

Gene disrupted in

Df(3L)brm11

(Von Stetina et al., 2008)

Inferred from location ( 6 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

partially lethal - majority die, with Scer\GAL4^pnr-MD237

elgi^GD9268

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

elgi^GD9268

viable, with Scer\GAL4^Mef2.PR

elgi^GD9268

viable, with Scer\GAL4^tin.CΔ4

elgi^GD9268

Other Phenotypes

Allele

abnormal flight, with Scer\GAL4^Ddc.PL

elgi^UAS.Tag:HA

abnormal neuroanatomy | adult stage, with Scer\GAL4^Ddc.PL

elgi^UAS.Tag:HA

abnormal size | adult stage | male, with Scer\GAL4^nub-AC-62

abnormal size | adult stage | male (with elgi¹)

elgi²

abnormal size | adult stage | male (with elgi²)

elgi¹

abnormal size | adult stage | recessive

elgi¹

abnormal size | third instar larval stage

elgi¹

visible, with Scer\GAL4^pnr-MD237

elgi^GD9268

visible | adult stage | male, with Scer\GAL4^nub-AC-62

visible | adult stage | male (with elgi¹)

elgi²

visible | adult stage | male (with elgi²)

elgi¹

visible | adult stage | recessive

elgi¹

Phenotype manifest in

Allele

dopaminergic neuron | adult stage, with Scer\GAL4^Ddc.PL

elgi^UAS.Tag:HA

mesonotum, with Scer\GAL4^pnr-MD237

elgi^GD9268

oocyte

elgi¹

oocyte (with elgi¹)

elgi²

oocyte (with elgi²)

elgi¹

wing | male

elgi¹

wing | male, with Scer\GAL4^nub-AC-62

wing | male (with elgi¹)

elgi²

wing | male (with elgi²)

elgi¹

wing disc | third instar larval stage

elgi¹

wing hair, with Scer\GAL4^nub-AC-62

elgi^{CS.UAS.Tag:MYC,Tag:HA}

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (40)

Hsap\RNF41

13 of 14

Yes

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\RING1

1 of 14

Hsap\RNF8

1 of 14

Yes

Hsap\RNF114

1 of 14

Yes

Hsap\RNF125

1 of 14

Hsap\RNF138

1 of 14

Yes

Hsap\RNF146

1 of 14

Hsap\RNF166

1 of 14

Yes

Hsap\RNF170

1 of 14

Yes

Hsap\RNF180

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\TRIM6

1 of 14

Yes

Hsap\TRIM8

1 of 14

Yes

Hsap\TRIM21

1 of 14

Yes

Hsap\TRIM22

1 of 14

Yes

Hsap\TRIM31

1 of 14

Yes

Hsap\TRIM35

1 of 14

Yes

Hsap\TRIM50

1 of 14

Yes

Hsap\TRIM62

1 of 14

Yes

Hsap\TRIM63

1 of 14

Yes

Hsap\TRIM68

1 of 14

Hsap\TRIM75P

1 of 14

Yes

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (32)

Rnor\Rnf41

14 of 14

Yes

3 of 14

3 of 14

2 of 14

2 of 14

2 of 14

2 of 14

Yes

Rnor\Traf4

2 of 14

Rnor\Traf5

2 of 14

Rnor\Traf7

2 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Rnor\RGD1565844

1 of 14

Yes

Rnor\Ring1

1 of 14

Rnor\Rnf8

1 of 14

Yes

Rnor\Rnf114

1 of 14

Yes

Rnor\Rnf125

1 of 14

Yes

Rnor\Rnf138

1 of 14

Yes

Rnor\Rnf146

1 of 14

Rnor\Rnf166

1 of 14

Yes

Rnor\Rnf170

1 of 14

Yes

Rnor\Trim3

1 of 14

Rnor\Trim8

1 of 14

Yes

Rnor\Trim21

1 of 14

Yes

Rnor\Trim50

1 of 14

Yes

Rnor\Trim62

1 of 14

Yes

Rnor\Trim63

1 of 14

Yes

Rnor\Trim65

1 of 14

Yes

Mus musculus (laboratory mouse) (32)

Mmus\Rnf41

14 of 14

Yes

Mmus\Rnf151

3 of 14

Mmus\Traf3

3 of 14

Yes

3 of 14

3 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Mmus\Ring1

1 of 14

Mmus\Rnf8

1 of 14

Yes

Mmus\Rnf114

1 of 14

Yes

Mmus\Rnf125

1 of 14

Yes

Mmus\Rnf138

1 of 14

Yes

Mmus\Rnf138rt1

1 of 14

Yes

Mmus\Rnf146

1 of 14

Mmus\Rnf166

1 of 14

Yes

Mmus\Rnf170

1 of 14

Yes

Mmus\Traf5

1 of 14

Mmus\Trim3

1 of 14

Mmus\Trim8

1 of 14

Yes

Mmus\Trim21

1 of 14

Yes

Mmus\Trim30b

1 of 14

Yes

Mmus\Trim30d

1 of 14

Yes

Mmus\Trim62

1 of 14

Yes

Mmus\Trim63

1 of 14

Yes

Xenopus tropicalis (Western clawed frog) (29)

Xtro\rnf41

11 of 13

Yes

2 of 13

2 of 13

2 of 13

2 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\pdzrn3

1 of 13

Xtro\rnf112.1

1 of 13

Xtro\rnf170

1 of 13

Yes

Xtro\scaf11

1 of 13

Yes

Xtro\topors

1 of 13

Xtro\traf1

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\trim69.1

1 of 13

Xtro\uhrf2

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

Danio rerio (Zebrafish) (57)

Drer\rnf41

14 of 14

Yes

Drer\rnf41l

3 of 14

Drer\rnf151

3 of 14

Drer\traf1

3 of 14

Yes

3 of 14

3 of 14

3 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

Yes

Drer\btr02

1 of 14

Yes

Drer\btr05

1 of 14

Yes

Drer\btr16

1 of 14

Yes

Drer\btr22

1 of 14

Yes

Drer\btr23

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Drer\ftr69

1 of 14

Yes

Drer\ftr70

1 of 14

Drer\ftr86

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Drer\lonrf1

1 of 14

Drer\rag1

1 of 14

Yes

Drer\rnf8

1 of 14

Yes

Drer\rnf114

1 of 14

Yes

Drer\rnf146

1 of 14

Drer\rnf166

1 of 14

Yes

Drer\rnf169

1 of 14

Yes

Drer\rnf180b

1 of 14

Yes

Drer\rnft1

1 of 14

Drer\si:ch73-106l15.3

1 of 14

Yes

Drer\si:ch211-12p12.2

1 of 14

Yes

Drer\si:dkey-183n20.15

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Drer\trim25l

1 of 14

Yes

Drer\trim35-1

1 of 14

Yes

Drer\trim35-7

1 of 14

Yes

Drer\trim35-19

1 of 14

Yes

Drer\trim35-27

1 of 14

Yes

Drer\trim35-28

1 of 14

Yes

Drer\trim35-40

1 of 14

Yes

Drer\trim62.1

1 of 14

Yes

Drer\trim107

1 of 14

Yes

Drer\trim108

1 of 14

Yes

Drer\uhrf1

1 of 14

Yes

Drer\zgc:173581

1 of 14

Yes

Caenorhabditis elegans (Nematode, roundworm) (5)

Cele\trf-1

3 of 14

Yes

2 of 14

1 of 14

1 of 14

1 of 14

Anopheles gambiae (African malaria mosquito) (11)

Agam\AgaP_AGAP001882

12 of 12

Yes

3 of 12

2 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (15)

Atha\COP1

2 of 13

Yes

Atha\AT1G50410

1 of 13

Atha\AT2G41980

1 of 13

Atha\AT3G58400

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Saccharomyces cerevisiae (Brewer's yeast) (0)

Schizosaccharomyces pombe (Fission yeast) (1)

Spom\SPCC548.05c

1 of 12

Yes

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:elgi. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (15)

5 of 13

3 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Sce

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Allele

Disease

Evidence

References

elgi^UAS.Tag:HA

model of neurodegenerative disease

CEA

(Tan et al., 2011)

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Allele

Disease

Interaction

References

elgi^UAS.Tag:HA

model of neurodegenerative disease

is ameliorated by Hsap\PRKN^UAS.cYa

(Tan et al., 2011)

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

RNF41; ring finger protein 41

13 of 14

620051

RNF151; ring finger protein 151

3 of 14

TRAF3; TNF receptor associated factor 3

3 of 14

601896

ENCEPHALOPATHY, ACUTE, INFECTION-INDUCED (HERPES-SPECIFIC), SUSCEPTIBILITY TO, 5; IIAE5

TRAF4; TNF receptor associated factor 4

3 of 14

602464

TRAF5; TNF receptor associated factor 5

3 of 14

602356

TRAF6; TNF receptor associated factor 6

3 of 14

602355

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Show neighbor-neighbor interactions:

Off

Show/hide secondary interactors
(data from AllianceMine provided by esyN)

Select Layout:

Force Directed

Circle

Concentric

Legend:

Protein

RNA

Selected Interactor(s)

Other Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

elgi - CG7789

two hybrid

(Hu et al., 2017.6.13)

elgi - Cdc37

two hybrid

(Hu et al., 2017.6.13)

elgi - Myo10A

pull down, autoradiography, two hybrid

(Liu et al., 2008)

elgi - dachs

anti tag coimmunoprecipitation, anti tag western blot

(Misra and Irvine, 2019)

elgi - endos

pull down, autoradiography

(Kim et al., 2012, Von Stetina et al., 2008)

elgi - park

two hybrid

(Zhong et al., 2005)

elgi - pkaap

two hybrid

(Hu et al., 2017.6.13)

Summary of Genetic Interactions

esyN Network Diagram

Other Interaction Browsers

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

MIST (protein-protein) - An integrated Molecular Interaction Database

39735

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Endocytosis

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Class of Gene

gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-43

Cytogenetic map

72B2-72C1

Sequence location

3L:15,956,550..15,958,433 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

72B2-72C1

Limits computationally determined from genome sequence between P{EP}Tfb2^EP572 and P{lacW}th^j5C8&P{PZ}Mbs⁰³⁸⁰²

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

3-43

(FlyBase, 2016)

3-38.1

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (11)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

86016

w¹¹¹⁸; PBac{RB}elgi^e01779

85306

w^*; P{UASp-elgi.PrA}3/TM3, Sb¹

603608

y¹ v¹; P{TRiP.HMS06267}attP40/CyO

602403

y¹ w¹; P{TKO-UAS.GS06210}attP40/CyO

98108

y¹ w^*; elgi¹/TM3, Sb¹

98558

y¹ w^*; TI{KozakGAL4}elgi^{CR70596-KO-kG4}/TM3, Sb¹ Ser¹

17033R-2

17033R-3

v109617

v32830

w¹¹¹⁸; P{GD9268}v32830

v32832

w¹¹¹⁸; P{GD9268}v32832

Genomic Clones (9)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (34)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

LD41235

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0283649

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Relationship to Other Genes

Source for database merge of

Source for merge of: elgi Nrdp1

(FlyBase, 1992-)

Additional comments

FlyBase curator comment: The description of 'Nrdp1' in FBrf0216900 (which is authored by the same group as FBrf0184054, where 'Nrdp1' was originally mentioned) matches the product of the 'elgi' gene; the orthology relationship asserted in FBrf0216900 and FBrf0184054 between human NRPD1 (aka RNF41) and Nrdp1/elgi is confirmed by the HGNC:HCOP and DRSC:DIOPT tools.

(FlyBase, 1992-)

Nomenclature History

Source for database identify of

Source for identity of: elgi CG17033

(Von Stetina et al., 2008)

Nomenclature comments

Etymology

The gene is named "early girl" based on the mutant phenotype; progression from prophase I to metaphase I occurs prematurely in mutant oocytes.

(Von Stetina et al., 2008)

Synonyms and Secondary IDs (7)

Reported As

Symbol Synonym

Name Synonyms

CG17033

Early Girl

(Das and Arur, 2022)

Nrdp1

early girl

(Von Stetina et al., 2008)

Secondary FlyBase IDs

FBgn0036546
FBgn0083166

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 40 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

39735

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9VUV7

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Q9VUV7

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9VUV7

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0036546

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

39735/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0283649

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0283649

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG17033

MARRVEL_MODEL - MARRVEL (model organism gene)

39735

Linkouts

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0283649

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0036546

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0283649

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG17033

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC002979

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Endocytosis

MIST (protein-protein) - An integrated Molecular Interaction Database

39735

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

References (45)

The following external sites may use different assemblies or annotations than FlyBase.

4.63

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